Scandinavian Journal of Gastroenterology最新文献

{"title":"Rethinking iron therapy in IBD: integrating the microbiota perspective.","authors":"Wojciech Marlicz, Karolina Skonieczna-Żydecka, Igor Łoniewski, Anastasios Koulaouzidis","doi":"10.1080/00365521.2025.2525909","DOIUrl":"https://doi.org/10.1080/00365521.2025.2525909","url":null,"abstract":"<p><p>Iron deficiency and anemia are common in patients with inflammatory bowel disease (IBD), requiring effective and well-tolerated iron replacement strategies. While oral iron is widely used, growing evidence suggests it can disrupt the gut microbiota by reducing beneficial commensal bacteria and promoting pro-inflammatory shifts in the intestinal environment. These changes may exacerbate mucosal inflammation and contribute to gastrointestinal side effects, often resulting in poor adherence. Intravenous iron, by bypassing the gastrointestinal tract, appears to have a less disruptive effect on the microbiota and may more reliably restore iron stores, particularly in patients with active disease or intolerance to oral formulations. Current expert recommendations support intravenous iron as the first-line option in such cases, though oral iron remains a practical choice for selected patients with mild anemia and inactive disease. Emerging research also raises concerns about the safety of oral iron in vulnerable populations, as it may promote dysbiosis and expansion of potentially pathogenic bacteria. In response, adjunctive strategies are being explored to support the microbiota and improve the tolerability and efficacy of oral iron. Incorporating microbiota-related considerations into treatment decisions may enhance outcomes and reduce side effects. Future clinical guidelines should reflect the evolving understanding of the gut microbiome's role in iron metabolism and inflammation, promoting more personalized, microbiota-conscious approaches to iron therapy in IBD.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"1-3"},"PeriodicalIF":1.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of mucin phenotypes, macroscopic type, and location with invasion depth in early nonampullary duodenal carcinomas.","authors":"Keiichi Hashiguchi, Hiroko Inomata, Hirokazu Kurohama, Junya Shiota, Taro Akashi, Maiko Tabuchi, Moto Kitayama, Kayoko Matsushima, Yuko Akazawa, Naoyuki Yamaguchi, Ken Ohnita, Kengo Kanetaka, Shinji Okano, Hisamitsu Miyaaki","doi":"10.1080/00365521.2025.2522466","DOIUrl":"https://doi.org/10.1080/00365521.2025.2522466","url":null,"abstract":"<p><strong>Objective: </strong>To investigate retrospectively the clinicopathological features of nonampullary duodenal intramucosal carcinoma (M-Ca) and submucosal carcinoma (SM-Ca).</p><p><strong>Materials and methods: </strong>Seventy-three patients (67 with M-Ca and seven with SM-Ca) were included. The assessed clinical variables included patient age, sex, treatment procedure, lesion location, color, and macroscopic type. Pathological outcomes included invasion depth, predominant histological type, lymphovascular invasion, and mucin phenotype.</p><p><strong>Results: </strong>SM-Ca lesions were predominantly located in the duodenal bulb (28.6%) or the oral side of the major papilla in the second portion (57.1%), while M-Ca lesions were primarily located in the second portion (97.0%) (<i>p</i> = 0.029). The superficially elevated type was predominant in the M-Ca group (43.3%), while the protruded type was predominant in the SM-Ca group (42.9%) (<i>p</i> = 0.034). A submucosal tumor-like appearance was more prevalent in the SM-Ca group (28.6%) than in the M-Ca group (1.5%) (<i>p</i> = 0.022). Well-differentiated adenocarcinomas were predominant in both groups (M-Ca, 97%; SM-Ca, 71.4%), with moderately differentiated and papillary adenocarcinomas being more prevalent in the SM-Ca group (14.3% each) (<i>p</i> = 0.042). The gastric mucin phenotype was significantly more prevalent in the SM-Ca group (71.4%) than in the M-Ca group (2.6%) (<i>p</i> < 0.0001). The median depth of submucosal invasion was 1,200 µm in the SM-Ca group. No lymph node metastasis or recurrence was observed.</p><p><strong>Conclusions: </strong>Nonampullary duodenal submucosal carcinomas are characterized by their location on the oral side of the major papilla, protruded macroscopic type, and gastric mucin phenotype. These findings offer insights into distinguishing M-Ca from SM-Ca.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HCC-surveillance is associated with improved HCC-related mortality in patients with cirrhosis - a case-control study.","authors":"Hannes Hegmar, Bonnie Bengtsson, Sofia Ullman, Ian A Rowe, Per Stål, Hannes Hagström","doi":"10.1080/00365521.2025.2517208","DOIUrl":"https://doi.org/10.1080/00365521.2025.2517208","url":null,"abstract":"<p><strong>Background and aims: </strong>Surveillance for hepatocellular carcinoma (HCC) with ultrasound screening is recommended by guidelines. However, there are conflicting data whether HCC-surveillance reduces HCC-related mortality in patients with cirrhosis. The aim of this study was to validate previous findings that found no association between HCC-surveillance and decreased HCC-related mortality.</p><p><strong>Methods: </strong>This was a case-control study in patients with cirrhosis from Stockholm County, Sweden. Cases died from HCC between 2004 and 2020. Controls did not die from HCC, and were matched to cases based on age, sex, etiology of cirrhosis, year of cirrhosis diagnosis, hospital site, MELD, and Child-Pugh scores. An adjusted logistic regression model was used to compare exposure to screening ultrasounds 2 years prior to HCC diagnosis between cases and controls. An odds ratio below one would suggest an association between HCC surveillance and decreased HCC-related mortality.</p><p><strong>Results: </strong>A total of 1272 patients with cirrhosis and HCC died during follow-up, and 516 of these were excluded as potential cases due to a diagnosis of HCC near the cirrhosis diagnosis. From the potential cases 72 cases and 72 controls were matched. The adjusted odds ratio was 0.33 (95% Confidence Interval [CI] = 0.14-0.78).</p><p><strong>Conclusions: </strong>HCC surveillance was associated with decreased HCC-related mortality, indicating that HCC surveillance should continue as recommended in guidelines. However, many patients who died from HCC were diagnosed with HCC close to the cirrhosis diagnosis, suggesting that identifying patients with cirrhosis earlier is highly important for improving HCC-related mortality.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omic analysis identifies cholesterol metabolism related protein ARV1 as a novel biomarker for Colon adenocarcinoma patients with adenomatous polyposis.","authors":"Yu-Cheng Zhu, Jun Zhang, Kun Liu, Ya-Bin Cheng, Wei Jiang","doi":"10.1080/00365521.2025.2518461","DOIUrl":"10.1080/00365521.2025.2518461","url":null,"abstract":"<p><strong>Objectives: </strong>Familial adenomatous polyposis (FAP) is typically characterized by numerous adenomatous polyps that will inevitably progress to adenocarcinomas. To enhance the clinical management of colon adenocarcinoma (COAD), a deeper understanding of the molecular mechanisms driving malignant transformation in pre-cancerous adenomatous polyposis, as well as the identification of predictive biomarkers, is essential.</p><p><strong>Methods: </strong>In the present study, clinical samples were collected from rare patients with COAD and FAP, and metabolomic and proteomic analyses were performed to elucidate the mechanisms of canceration in FAP patients.</p><p><strong>Results: </strong>The multi-omics analysis showed that cholesterol metabolism is highly activated in COAD tissue and identified 64 genes that are highly expressed in COAD and significantly correlated with prognosis. Improved <i>in situ</i> sequencing (IISS) identified <i>ARV1</i> (ACAT related enzyme 2 required for viability 1) as a critical regulator of cholesterol metabolism. Finally, bioinformatics analysis using the HPA database showed that <i>ARV1</i> expression is negatively correlated with COAD TNM stage; thus, indicating that <i>ARV1</i> might play a role as a tumor suppressor in colon cancer.</p><p><strong>Conclusions: </strong>Overall, cholesterol metabolism was found to be involved in colon adenocarcinoma tumorigenesis and <i>ARV1</i> was identified as a key factor in the early stage of FAP transformation.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"1-12"},"PeriodicalIF":1.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunogenicity of the Comirnaty Omicron XBB.1.5 booster COVID-19 mRNA vaccine in patients with cirrhosis.","authors":"Samer Al-Dury, Sigrun Einarsdottir, Ellen Fridriksson, Linn Dahlsten Andius, Hao Wang, Sinan Sharba, Amin Mountagui, Johan Waern, Johan Ringlander, Jesper Waldenström, Anna Martner, Kristoffer Hellstrand, Martin Lagging","doi":"10.1080/00365521.2025.2518466","DOIUrl":"https://doi.org/10.1080/00365521.2025.2518466","url":null,"abstract":"<p><p><b>Objective:</b> : To evaluate the durability of immune responses following prior COVID-19 vaccinations and assess the immunogenicity of a fifth mRNA-based COVID-19 booster dose in patients with liver cirrhosis.</p><p><p><b>Materials and Methods</b>: In this longitudinal cohort study, 33 patients with liver cirrhosis received a fifth booster dose of the Comirnaty Omicron XBB.1.5® (Pfizer-BioNTech) mRNA vaccine. Peripheral blood samples were collected prior to and four weeks after vaccination. Humoral immunity was assessed by measuring serum antibodies against the receptor-binding domain of spike (anti-RBD-S1) and nucleocapsid proteins. Cellular immunity was evaluated by quantifying ex vivo Spike 1 (S1)-specific T-cell responses, specifically IL-2 release.</p><p><p><b>Results</b>: The fifth mRNA vaccine dose led to a significant increase in anti-RBD-S1 antibody levels and S1-induced IL-2 release, indicating enhanced humoral and cellular immune responses. The optimal interval for booster administration to maintain elevated antibody titers was identified as 10-12 months. Additionally, a history of prior COVID-19 infection significantly influenced post-booster antibody responses.</p><p><p><b>Conclusions</b>: A fifth mRNA-based COVID-19 booster dose significantly augments both humoral and cellular immunity in patients with liver cirrhosis. These findings support the use of a single annual booster dose to maintain adequate immune protection in this vulnerable population.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipofuscinosis as a novel discriminating feature for drug-induced liver injury from autoimmune hepatitis.","authors":"Sabine Weber, Franziska Erhardt, Jens Neumann, Julian Allgeier, Didem Saka, Nirali Donga, Izabel Mircheva, Rochell Balakumar, Christian M Lange, Alexander L Gerbes","doi":"10.1080/00365521.2025.2517207","DOIUrl":"https://doi.org/10.1080/00365521.2025.2517207","url":null,"abstract":"<p><strong>Background and objective: </strong>Differentiating drug-induced liver injury (DILI) and autoimmune hepatitis (AIH) is a diagnostic challenge. Liver biopsy is recommended in unclear cases, however, clear distinguishing patterns are unknown. We therefore aimed to further identify histopathological features that can discriminate DILI from AIH.</p><p><strong>Methods: </strong>The clinical and histological data of well-characterised 136 DILI and 43 AIH patients from our prospective cohort on patients with acute liver injury and potential drug-related cause were analysed. Logistic binary regression was performed to identify models that could differentiate both two entities.</p><p><strong>Results: </strong>Histopathological findings showed high overlaps between DILI and AIH, and overall concordance between histological and clinical diagnosis was low (48.9%). While interface hepatitis, plasma cell infiltration, and portal-intralobular infiltration were favouring AIH, relevant proportions of DILI patients also presented with those features (44.1%, 46.3% and 29.2%, respectively). Interestingly, on multivariate analysis, lipofuscinosis was the only independent predictor of DILI diagnosis, showing a strong association with DILI diagnosis (odds ratio [OR] 10.8; positive predictive value [PPV] 96.2%). Moreover, logistic regression analysis showed that a model combining different histopathological features (lack of interface hepatitis, fibrosis and eosinophils together with presence of cholestasis, steatosis and lipofuscinosis) could differentiate DILI from AIH with an accuracy of 76.5% and a strikingly high sensitivity of 94.9%.</p><p><strong>Conclusions: </strong>DILI and AIH showed similar histological patterns, however lipofuscinosis was identified as a novel distinctive feature for DILI with an extraordinarily high PPV. Moreover, a model combining a variety of histological features could differentiate both entities with high sensitivity.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis is associated with increased disease activity in a Swedish cohort of patients with inflammatory bowel disease.","authors":"Gorm Roager Madsen, Kristina Bertl, Amanda Wåhlin, Daniel Najjar, Nikolaos Pandis, Andreas Stavropoulos, Johan Burisch","doi":"10.1080/00365521.2025.2517217","DOIUrl":"10.1080/00365521.2025.2517217","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis and inflammatory bowel disease (IBD) are chronic, progressive inflammatory diseases with shared aetiopathogenetic mechanisms. Research suggests that IBD patients are at increased risk of developing periodontitis, which may, in turn, exacerbate IBD activity and disability. This study examines whether periodontitis is associated with increased IBD activity, severity, disability and reduced quality of life.</p><p><strong>Methods: </strong>An online survey was distributed to Swedish IBD patients, covering demographics, oral health, and IBD characteristics. Validated tools were used where possible, and data were combined with a similar Danish study.</p><p><strong>Results: </strong>A total of 786 IBD patients (371 Crohn's disease [CD] and 415 ulcerative colitis [UC]) completed the survey. Self-reported severe periodontitis was significantly associated with poorer IBD disability scores [coef. 5.07 (1.86; 8.27)], more self-reported active disease [OR 1.72 (1.19; 2.49)], higher self-reported disease activity in the preceding 12 months [OR 1.44 (1.05; 1.98)], and reduced quality of life [Coef. -1.45 (-3.01; 0.10)]. Self-reported tooth loss also correlated with poorer disability scores [Coef. 4.47 (0.71; 8.22)] and showed a trend toward greater self-reported disease severity [OR 1.57 (0.97; 2.52)]. Combined Danish-Swedish analysis confirmed these findings.</p><p><strong>Conclusions: </strong>This study, although based purely on self-reported data at a single timepoint, reinforces associations between periodontitis, tooth loss and worse IBD outcomes, emphasizing the need for greater focus on oral health in IBD management.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"1-17"},"PeriodicalIF":1.6,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of gastric epithelial neoplasm of fundic-gland mucosa lineage diagnosed by medical checkup findings and time-course changes.","authors":"Eiko Okimoto, Norihisa Ishimura, Kyoichi Adachi, Yuri Ebisutani, Yuko Matsubara, Manabu Yoshida, Hiroshi Miura, Shunji Ishihara","doi":"10.1080/00365521.2025.2496935","DOIUrl":"10.1080/00365521.2025.2496935","url":null,"abstract":"<p><strong>Background: </strong>This study was performed to investigate the prevalence of gastric epithelial neoplasm of fundic-gland mucosa lineage (GEN-FGML) and time-course changes in endoscopic findings in affected subjects who underwent an esophagogastroduodenoscopy (EGD) examination as part of an annual checkup.</p><p><strong>Methods: </strong>A total of 39,292 EGD examinations (25,228 men, 14,034 women; mean age: 53.6 years) were performed between April 2016 and March 2024. The prevalence of GEN-FGML was analyzed, and time-course changes noted in endoscopic findings of diagnosed tumors were investigated by comparison with previous endoscopic images.</p><p><strong>Results: </strong>During the study period, we identified 19 patients with 20 GEN-FGML diagnosed based on endoscopic and histological results, with a prevalence of 0.048%. Prevalence was not different between <i>Helicobacter pylori</i>-uninfected and -eradicated cases (0.050% and 0.051%, respectively). Endoscopy findings of 16 of these tumors for which time-course changes could be investigated (median observation period: 8.5 years) showed that 15 were unchanged in size in comparison with previous EGD findings, while one showed enlargement. In addition, three lesions diagnosed after <i>H. pylori</i> eradication were unchanged in size compared to before eradication.</p><p><strong>Conclusions: </strong>The prevalence of GEN-FGML by screening EGD was 0.048%, with prevalence not different between <i>H. pylori-</i>uninfected and -eradicated subjects. Enlargement over time was not observed in almost all cases, and <i>H. pylori</i> infection status was considered not to influence changes in tumor size.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"494-501"},"PeriodicalIF":1.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of biologics on ulcerative colitis-related colectomy rate: results of a 22-year study.","authors":"Nur Beyza Tukek, Oguz Kagan Bakkaloglu, Gozde Sen, İbrahim Hatemi, Aykut Ferhat Celik, Yusuf Ziya Erzin","doi":"10.1080/00365521.2025.2497954","DOIUrl":"10.1080/00365521.2025.2497954","url":null,"abstract":"<p><strong>Background: </strong>To assess the impact of the biological era on colectomy rates in ulcerative colitis (UC) patients and identify factors associated with the necessity for colectomy in a large cohort from Eastern Europe.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on UC patients followed at a tertiary care center covering 1999 to 2021. Patients who underwent colectomy due to disease activity were compared to those who did not. Factors related to colectomy and the influence of the biological era were analyzed.</p><p><strong>Results: </strong>Among 1197 patients with a median follow-up of 3.3 years, 18% received biological agents and 5.3% underwent colectomy due to disease activity. The colectomy rate was lower in the biological era compared to the pre-biological era (2% vs. 12%; <i>p</i> < 0.001). Independent predictors of colectomy included steroid dependency, steroid resistance, lack of mucosal remission, and elevated CRP levels. Patients who achieved and maintained mucosal remission and had CRP levels below 3 mg/L had a significantly lower risk of colectomy.</p><p><strong>Conclusions: </strong>The biological era has significantly reduced colectomy rates in UC patients. Achieving mucosal remission and maintaining low CRP levels are essential for preventing colectomy and improving long-term outcomes.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"548-557"},"PeriodicalIF":1.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient polyp detection algorithm based on deep learning.","authors":"Xing Sun, Jingang Ma, Yang Li","doi":"10.1080/00365521.2025.2503297","DOIUrl":"10.1080/00365521.2025.2503297","url":null,"abstract":"<p><strong>Objective: </strong>Colon polyp detection is crucial in reducing the incidence of colorectal cancer. However, due to the diverse morphology of colon polyps, their high similarity to surrounding tissues, and the difficulty of detecting small target polyps, false negatives and false positives are common problems.</p><p><strong>Methods: </strong>To address this, we propose a lightweight and efficient colon polyp detection model based on YOLOv10, a deep learning-based object detection method-EP-YOLO (Efficient for Polyp). By introducing the GBottleneck module, we reduce the number of parameters and accelerate inference; a lightweight GHead detection head and an additional small target detection layer are designed to enhance small target recognition ability; we propose the SE_SPPF module to improve attention on polyps while suppressing background noise interference; the loss function is replaced with Wise-IoU to optimize gradient distribution and improve generalization ability.</p><p><strong>Results: </strong>Experimental results on the publicly available LDPolypVideo (7,681 images), Kvasir-SEG (1,000 images) and CVC-ClinicDB (612 images) datasets show that EP-YOLO achieves precision scores of 94.17%, 94.32% and 93.21%, respectively, representing improvements of 2.10%, 2.05% and 1.42% over the baseline algorithm, while reducing the number of parameters by 16%.</p><p><strong>Conclusion: </strong>Compared with other mainstream object detection methods, EP-YOLO demonstrates significant advantages in accuracy, computational load and FPS, making it more suitable for practical medical scenarios in colon polyp detection.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"502-515"},"PeriodicalIF":1.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}