Scandinavian Journal of Gastroenterology最新文献_第4页

Pharmacologic neuromodulation for bloating. 腹胀的药理神经调节。

IF 1.7 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-08-08 DOI: 10.1080/00365521.2025.2544306

Elizabeth N Madva, Sanskriti Varma, Victoria Small, Mia Dekel, Silvia Salamone, Helen Burton-Murray, Braden Kuo, Kyle Staller

{"title":"Pharmacologic neuromodulation for bloating.","authors":"Elizabeth N Madva, Sanskriti Varma, Victoria Small, Mia Dekel, Silvia Salamone, Helen Burton-Murray, Braden Kuo, Kyle Staller","doi":"10.1080/00365521.2025.2544306","DOIUrl":"10.1080/00365521.2025.2544306","url":null,"abstract":"Background: Though bloating is a common and highly distressing symptom among patients with disorders of gut-brain interaction (DGBI), few targeted treatment options exist. In this study, we examined the use and efficacy of pharmacologic neuromodulators to treat bloating specifically.Methods: In a retrospective study of consecutively referred patients with a DGBI (N = 77; ages 18-74, 87% female) to a tertiary neurogastroenterology clinic who were prescribed a neuromodulator for a primary complaint of bloating in 2016-2022, the degree of patient-reported bloating response (0-100%) to the maximum dose of a prescribed neuromodulator was examined using multivariable logistic regression, adjusted for key covariates.Results: Forty-seven (61.0%) patients reported any response (>0%) to neuromodulation and 28 (36.4%) met the a priori responder definition (≥50% improvement). Duloxetine was the most commonly prescribed neuromodulator (n = 52, 67.5%). On multivariable analysis, only younger age was associated with an increased odds of neuromodulator response (OR 1.04, 95% CI [1.08, 1.01]).Conclusions: Pharmacologic neuromodulators may show promise as a tool for the treatment of bloating, and further research is warranted.","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"874-878"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of date of diagnosis and disease location of inflammatory bowel disease in the Danish National Patient Registry and the Danish Pathology Registry using a regional cohort. 在丹麦国家患者登记处和丹麦病理登记处使用区域队列验证炎症性肠病的诊断日期和疾病位置。

IF 1.7 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-08-12 DOI: 10.1080/00365521.2025.2544309

Linéa Bonfils, Laurits T Dalsgaard, Gry J Poulsen, Mikkel Eld, Tine Jess, Lone Larsen, Kristine H Allin

{"title":"Validation of date of diagnosis and disease location of inflammatory bowel disease in the Danish National Patient Registry and the Danish Pathology Registry using a regional cohort.","authors":"Linéa Bonfils, Laurits T Dalsgaard, Gry J Poulsen, Mikkel Eld, Tine Jess, Lone Larsen, Kristine H Allin","doi":"10.1080/00365521.2025.2544309","DOIUrl":"10.1080/00365521.2025.2544309","url":null,"abstract":"Objectives: The Danish National Patient Registry (NPR) is an obvious source for investigating the period preceding inflammatory bowel disease (IBD). However, accuracy of diagnosis date in the NPR is unknown. Further, assessment of IBD location in the NPR has shown inconsistent results. We identified date of IBD diagnosis in the NPR and captured IBD disease location from the Danish Pathology Registry (DPR) and validated both against the North Denmark IBD cohort (NorDIBD) as the gold standard.Materials and methods: We identified all patients with incident IBD in NorDIBD between 2000 and 2020. We compared diagnosis date in the NPR with the date in NorDIBD. Next, we inferred disease location from pathology codes in the DPR and compared with disease location in NorDIBD.Results: We identified 3163 patients with incident IBD. We found a mean of 8 (95% CI -36, 53) and 62 (95% CI 27, 96) days between date of diagnosis in the NPR and NorDIBD for Crohn's disease (CD) and ulcerative colitis (UC), respectively. We could infer disease location from pathology codes in 63% of patients with CD and 56% of UC patients. We found high sensitivity for colonic disease in CD and for ulcerative proctitis in UC.Conclusion: The date of IBD diagnosis in the NPR showed high validity. IBD location could be inferred via pathology codes for approximately 60% of patients with IBD, with high validity for colonic disease in CD and proctitis in UC. These findings are useful in future epidemiological studies in IBD.","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"900-909"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply: role of endoscopic ultrasonography in workup of patients with presumed idiopathic acute pancreatitis. 回复：超声内镜检查在特发性急性胰腺炎诊断中的作用。

IF 1.7 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-08-05 DOI: 10.1080/00365521.2025.2544308

Ida Saksenborg Kølle, Andreas Svenstrup Hesthaven, Søren Schou Olesen

引用次数: 0

Targeting colorectal adenomatous polyps in type 2 diabetes: development of a risk assessment model. 针对2型糖尿病患者结肠直肠腺瘤性息肉：风险评估模型的建立

IF 1.7 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-08-07 DOI: 10.1080/00365521.2025.2544311

Shuli Mu, Haie Li, Xiaona Che, Wenqian Sun, Leyi Zou, Xiaoguo Wei

{"title":"Targeting colorectal adenomatous polyps in type 2 diabetes: development of a risk assessment model.","authors":"Shuli Mu, Haie Li, Xiaona Che, Wenqian Sun, Leyi Zou, Xiaoguo Wei","doi":"10.1080/00365521.2025.2544311","DOIUrl":"10.1080/00365521.2025.2544311","url":null,"abstract":"Background and aims: This study aimed to identify independent risk factors for colorectal adenomatous polyps in patients with type 2 diabetes mellitus (T2DM) and to develop a predictive model to facilitate early and targeted screening.Methods: A total of 521 T2DM patients undergoing colonoscopy at Gansu Provincial People's Hospital (January 2022-May 2025) were retrospectively analyzed. Patients were randomly divided into a training set (n = 366) and a validation set (n = 155). The training set was further categorized into polyp and non-polyp groups. Logistic regression was used to identify independent risk factors and construct a predictive model, which was evaluated by ROC curve, calibration plot and decision curve analysis.Results: Age, homocysteine level, body mass index, fecal occult blood test positivity, diabetic peripheral neuropathy and diarrhea were identified as independent risk factors for colorectal adenomatous polyps in patients with T2DM. The predictive model demonstrated strong discrimination, with an area under the ROC curve of 0.878. At the optimal Youden index of 0.526, the model achieved a sensitivity of 0.749 and a specificity of 0.864. Calibration analysis showed good agreement between predicted and observed outcomes (χ2 = 6.173, p = 0.628).Conclusions: This predictive model, based on key clinical risk factors, provides an effective tool for assessing the risk of colorectal adenomatous polyps in T2DM patients, and may support early detection and targeted prevention strategies in clinical practice.","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"856-864"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of pancreatic exocrine insufficiency after first moderately severe or severe acute pancreatitis. 首次中重度或重度急性胰腺炎后胰腺外分泌功能不全的发展。

IF 1.7 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-07-17 DOI: 10.1080/00365521.2025.2533337

Outi Lindström, Elina Lietzen, Panu Mentula, Matti Tolonen, Päivi Siironen, Marianne Udd, Pauli Puolakkainen, Leena Kylänpää

{"title":"Development of pancreatic exocrine insufficiency after first moderately severe or severe acute pancreatitis.","authors":"Outi Lindström, Elina Lietzen, Panu Mentula, Matti Tolonen, Päivi Siironen, Marianne Udd, Pauli Puolakkainen, Leena Kylänpää","doi":"10.1080/00365521.2025.2533337","DOIUrl":"10.1080/00365521.2025.2533337","url":null,"abstract":"Objectives: Pancreatic necrosis may develop in moderately severe and severe acute pancreatitis (AP), and result in pancreatic exocrine insufficiency (PEI). The aim of this prospective study was to investigate development of PEI in patients recovering from the first attack of moderately severe or severe AP.Materials and methods: Altogether 70 patients were recruited. The development of PEI was determined by measuring the fecal elastase-1 (FE-1) during the hospitalization time, and in the follow up period 1-2 months and 12 months after discharge. Persistent PEI was defined as FE-1 level below 200 µg/g at 12 months follow up.Results: 52 patients completed the study. The median age was 53 years, 65% were male, and 63% had severe AP. The most common etiology was alcohol (58%). After 12 months of discharge the FE-1 values were normal in 67% of patients, showed moderate insufficiency in 6% and severe insufficiency in 27% of patients. For pancreatic function there was a tendency to recover in one year follow up. However, four (17%) patients with initially normal FE-1 level developed persistent PEI, whereas three (25%) and eight (57%) patients with initially moderate or severe insufficiency, had persistent PEI at 12 months. During hospitalization new onset diabetes, extent (>50%) and anatomical site (body) of pancreatic necrosis, and low FE-1 level (median 28 µg/g, range 15-161) were predictive for persistent PEI at 12 months.Conclusion: Around a third of patients with first attack of moderately severe or severe AP develop PEI.Registered in: ClinicalTrials.gov (NCT02563080).ClinicalTrials.gov identifier: NCT02563080.","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"921-927"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of endoscopic ultrasonography in workup of patients with presumed idiopathic acute pancreatitis. 超声内镜检查在特发性急性胰腺炎诊断中的作用。

IF 1.7 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-07-21 DOI: 10.1080/00365521.2025.2537891

Serdar Akca, Osman Cagin Buldukoglu, Serkan Ocal

引用次数: 0

Comment on: lipofuscinosis as a novel discriminating feature for drug-induced liver injury from autoimmune hepatitis. 评论：脂褐素沉着症是自身免疫性肝炎药物性肝损伤的一个新的鉴别特征。

IF 1.7 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-08-01 DOI: 10.1080/00365521.2025.2542871

Gokhan Koker, Merve Eren Durmus

引用次数: 0

Cardiovascular implications of MASLD: overview of the evidence. MASLD对心血管的影响：证据综述。

IF 1.7 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-07-28 DOI: 10.1080/00365521.2025.2536585

Belend Ismail, Puria Nabilou, Lise Lotte Gluud, Søren Møller

引用次数: 0

Key variables associated with gastroparesis in diabetes patients with gastroparesis-like symptoms. 伴有胃轻瘫样症状的糖尿病患者胃轻瘫的相关关键变量

IF 1.7 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-07-12 DOI: 10.1080/00365521.2025.2531038

Mattis Bekkelund, Elisabeth K Steinsvik, Jørgen Valeur, Eirik Søfteland, Georg Dimcevski, Dag A Sangnes

{"title":"Key variables associated with gastroparesis in diabetes patients with gastroparesis-like symptoms.","authors":"Mattis Bekkelund, Elisabeth K Steinsvik, Jørgen Valeur, Eirik Søfteland, Georg Dimcevski, Dag A Sangnes","doi":"10.1080/00365521.2025.2531038","DOIUrl":"10.1080/00365521.2025.2531038","url":null,"abstract":"Background/aims: Gastroparesis is a late complication of diabetes mellitus characterized by delayed gastric emptying and upper gastrointestinal symptoms. The disorder substantially impacts the quality of life, glycemic stability, nutrition and absorption of orally administered drugs. Since symptom severity is a poor predictor of gastric emptying status, the clinician has little to aid them in whom to refer for gastric emptying testing. In this study, we aim to identify clinical characteristics associated with delayed gastric emptying in diabetes patients with gastroparesis-like symptoms.Materials and methods: Diabetes patients consecutively referred to Haukeland University Hospital for assessment of gastroparesis-like symptoms underwent gastric emptying scintigraphy, blood samples and questionnaires for assessing gastrointestinal symptoms (Gastrointestinal Symptom Rating Scale), neuroticism (Eysenck Personality Questionnaire-Short Form), and symptoms of anxiety and depression (Hospital Anxiety & Depression Scale).Results: Seventy-one patients were included in the study, of which 28 displayed delayed gastric emptying. Delayed gastric emptying was characterized by having type 1 diabetes, younger age, lower BMI, presence of other late complications including distal symmetric polyneuropathy and retinopathy, higher Hb1Ac levels and lower albumin and hemoglobin levels. Symptoms were not related to gastric emptying status.Conclusion: We identified several clinical variables associated with delayed gastric emptying in diabetes patients with gastroparesis-like symptoms. These variables are commonly assessed during a medical consultation and may be used to aid the clinician in choosing who to refer for gastric emptying testing.","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"865-873"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic endoscopic resection as first-line management for grade 1-2 duodenal neuroendocrine tumors: a retrospective study. 诊断性内镜切除作为1-2级十二指肠神经内分泌肿瘤的一线治疗：一项回顾性研究。

IF 1.7 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-07-28 DOI: 10.1080/00365521.2025.2537883

Cheol Min Lee, Cheol Woong Choi, Dae Gon Ryu, Su Jin Kim, Su Bum Park, Jin Ook Jang, Eun Jung Choi, Jae Hun Chung, Si Hak Lee, Sun Hwi Hwang

{"title":"Diagnostic endoscopic resection as first-line management for grade 1-2 duodenal neuroendocrine tumors: a retrospective study.","authors":"Cheol Min Lee, Cheol Woong Choi, Dae Gon Ryu, Su Jin Kim, Su Bum Park, Jin Ook Jang, Eun Jung Choi, Jae Hun Chung, Si Hak Lee, Sun Hwi Hwang","doi":"10.1080/00365521.2025.2537883","DOIUrl":"10.1080/00365521.2025.2537883","url":null,"abstract":"Objectives: Duodenal neuroendocrine tumors are increasingly identified incidentally during screening endoscopy. While surgical resection is standard, the role of endoscopic resection, particularly for grade 1 and 2 tumors, remains under discussion. This study aimed to evaluate the feasibility and outcomes of diagnostic endoscopic resection in grade 1 or 2 duodenal neuroendocrine tumors.Methods: We retrospectively reviewed 40 patients with grade 1 or 2 duodenal neuroendocrine tumors treated at a single tertiary center between November 2008 and July 2023. Clinical, endoscopic, and histopathologic features were analyzed, including resection methods, complications, and long-term outcomes.Results: The mean tumor size was 7.4 ± 0.9 mm, with 80% of tumors <10 mm. Grade 1 tumors accounted for 90% of the cases. Endoscopic resection was performed in 28 patients; ligation-assisted endoscopic mucosal resection achieved a 100% complete (R0) resection rate. One patient had a perforation, which was successfully managed endoscopically. Five patients did not undergo resection following forceps biopsy. Two patients required additional surgery after endoscopic resection, and 7 underwent primary surgery. No patient exhibited lymph node or distant metastasis, and no recurrence was observed during a mean follow-up period of 59.0 ± 6.9 months.Conclusions: Endoscopic resection may be a safe and effective first-line treatment for grade 1 or 2 duodenal neuroendocrine tumors, including selected lesions >10 mm. Ligation-assisted endoscopic mucosal resection may be preferred for subcentimeter lesions. Diagnostic endoscopic resection should be considered in selected patients to avoid unnecessary surgery.","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"847-855"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0