Scandinavian Journal of Gastroenterology最新文献

{"title":"LncRNA MIR17HG drives cisplatin resistance partially via miR-138-5p/AKAP9 axis in cholangiocarcinoma.","authors":"Lingyu Tang, Yuting Wang, Yongzhen Chen, Boming Xu, Lin Miao, Liang Zhong","doi":"10.1080/00365521.2025.2450024","DOIUrl":"10.1080/00365521.2025.2450024","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to discover the role of lncRNA MIR17HG, referred to as MIR17HG, in cisplatin resistance for cholangiocarcinoma (CCA).</p><p><strong>Methods: </strong>QRT-PCR was conducted to measure the expression of MIR17HG in cisplatin-resistant/sensitive CCA cells and clinical CCA specimens. Log-rank test was used to analyze the survival curve. Cck8-assay and flow cytometry were employed to detect the sensitivity of CCA cells to cisplatin and the apoptosis rate following different treatments, respectively. The next-generation sequencing was carried out to get gene transcripts after silencing MIR17HG in HCCC-9810 cells. The LncBase database was used to predict the target miRNA of MIR17HG, and MS2 RIP assay and dual luciferase assay were conducted to confirm their binding. MiRwalk database and the RNA sequencing data were utilized to screen the key genes regulated by MIR17HG/miR-138-5p axis and a dual luciferase assay was performed to confirm the binding site of miR-138-5p with AKAP9. Immunoblotting was further employed to give assistant evidence. Rescue experiments were performed to observe the function of miR-138-5p and AKAP9 in MIR17HG-induced cisplatin resistance.</p><p><strong>Results: </strong>MIR17HG overexpression predicts cisplatin resistance and poor prognosis in CCA. MIR17HG could bind with miR-138-5p to release AKAP9, thereby inhibiting cisplatin-induced apoptosis and promoting cisplatin resistance in CCA. MIR17HG silencing in CCA cells leads to expression alteration of genes, which are enriched in platinum resistance-related pathways.</p><p><strong>Conclusions: </strong>LncRNA MIR17HG regulates platinum resistance-associated genes and promotes cisplatin resistance partially via the miR-138-5p/AKAP9 axis by inhibiting cisplatin-induced apoptosis in CCA.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"184-196"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of ALG8 in hepatocellular carcinoma and its diagnostic and prognostic significance.","authors":"Yang Haishen, Feiyu Jiang, Xinxin Si, Dan Sun, Haoran Fei, Dali Wang, Kai Li, Shengwang Du, Wei Hu, Zhong Wang","doi":"10.1080/00365521.2024.2433562","DOIUrl":"10.1080/00365521.2024.2433562","url":null,"abstract":"<p><strong>Background: </strong>Alpha-1,3-glucosyltransferase (ALG8), a key enzyme in protein glycosylation, is implicated in the oncogenesis and progression of several human malignancies. This study aimed to define the role of ALG8 in hepatocellular carcinoma (HCC) and uncover its mechanisms of action.</p><p><strong>Methods: </strong>ALG8 expression in HCC and normal tissues was analyzed using the TCGA and GEO databases, validated by RT-qPCR and western blot. Survival outcomes were evaluated <i>via</i> Cox analyses, and ALG8's impact on HCC behavior was examined through functional assays. GO, KEGG, and GSEA identified ALG8-related pathways, validated by biochemical assays.</p><p><strong>Results: </strong>In bioinformatics analyses, ALG8 was overexpressed in HCC tissues (<i>p</i> < 0.05 for all comparisons) and correlated with poorer survival (<i>p</i> = 0.006 and <i>p</i> = 0.025, respectively), establishing its role as an independent prognostic factor. <i>In vitro</i> experiments showed that knockdown of ALG8 reduced HCC cell proliferation, migration, and invasion. Using the STRING platform and TCGA-LIHC dataset, we identified ALG8-interacting genes and their associated differentially expressed genes (DEGs). GO and KEGG analyses further linked ALG8 to genes involved in glycosylation, signal release, and other processes, as well as pathways including neuroactive ligand-receptor interaction and N-Glycan biosynthesis. GSEA, corroborated by western blot and immunofluorescence, points to the Wnt/β-catenin signaling cascade as a probable mechanistic pathway through which ALG8 may modulate HCC progression.</p><p><strong>Conclusion: </strong>Elevated ALG8 expression in HCC is linked to worse outcomes and increased tumor aggressiveness, with silencing ALG8 reducing Wnt/β-catenin signaling, highlighting ALG8 as a potential therapeutic target.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"62-72"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of IBD on ability to work and study: a patient perspective.","authors":"Anssi Mustonen, Rasmus Rankala, Markku Voutilainen, Kalle Mattila","doi":"10.1080/00365521.2024.2440794","DOIUrl":"10.1080/00365521.2024.2440794","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to explore the multifaceted ways in which inflammatory bowel disease (IBD) negatively affects working life and studies.</p><p><strong>Material and methods: </strong>IBD patients were identified by diagnosis codes from the hospital records of a Finnish University Hospital. Patients were sent questionnaires <i>via</i> mail and text messages. Respondents, being 561 patients, formed the sample. Hospital records and data of medications were combined to questionnaire data.</p><p><strong>Results: </strong>Over a fifth of the patients reported having to change their job due to IBD, whereas a third of the sample had to modify their work due to IBD. On average, they had changed jobs once. Most common modifications were to do fewer hours or work during different hours, decreasing the physical burden of their work and moving their workplace closer to a toilet. Around a fifth of the sample' studies were negatively influenced by IBD. Interestingly, clinical parameters or sex did not affect the probability of job modifications, changes or negative effects on studies.</p><p><strong>Conclusions: </strong>IBD has a considerable negative impact on many patients' studies and working life that extends beyond commonly studied absenteeism and presenteeism.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"37-41"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The epidemiology of eosinophilic esophagitis in Sweden - a nationwide population-based study.","authors":"Aldona Dlugosz, Anders Berglund, Milica Uhde","doi":"10.1080/00365521.2024.2440787","DOIUrl":"10.1080/00365521.2024.2440787","url":null,"abstract":"<p><strong>Introduction: </strong>Eosinophilic esophagitis (EoE) is a chronic inflammatory condition that affects the esophagus. Previous studies have indicated a substantial increase of EoE over the last decades. The aim of the current study was to describe the incidence and prevalence of EoE over time and by geographical regions in Sweden, utilizing nationwide population-based registries.</p><p><strong>Material and methods: </strong>The number of hospital admissions (in-patient and out-patient) for patients were identified using ICD-10-SE code K20.9A from the National Patient Registry between 1st January 2011 and 31st December 2021. Crude incidence and prevalence numbers were presented per 100,000 person years and persons, respectively.</p><p><strong>Results: </strong>In 2011, no hospital visits of EoE were recorded. A total of 3,243 incident patients (2,379 (73.4%) men and 864 (26.6%) women) had a record of EoE between 2012 and 2021. The incidence increased over calendar year in where the incidence was from 1.59 per 100,000 person years in 2012 to 5.34 per 100,000 person years in 2021. The prevalence was 1.29 per 100,000 person years and 31.02 per 100,000 person years in 2012 and 2021, respectively. Major differences in the prevalence between geographical regions in Sweden were observed, e.g. in 2021, the prevalence was 12.24 in Västernorrland compared to 43.26 in Västra Götaland per 100,000 person years, which is similar to the prevalence in the Stockholm region.</p><p><strong>Conclusion: </strong>The incidence and prevalence of eosinophilic esophagitis has significantly increased over calendar year but differs between geographical regions in Sweden. These differences should be further investigated.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bedside endoscopic ultrasound guided gallbladder drainage in the Intensive Care Unit in critically ill patients.","authors":"Raj Jessica Thomas, Arjun Chatterjee, Mohamed Abdallah, Rajat Garg, Amandeep Singh, Prabhleen Chahal","doi":"10.1080/00365521.2024.2434631","DOIUrl":"10.1080/00365521.2024.2434631","url":null,"abstract":"<p><p>Cholecystectomy is the preferred treatment for acute cholecystitis in average surgical-risk patients. For those with high perioperative risk, percutaneous transhepatic gallbladder drainage (PT-GBD) and endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) are alternatives. However, PT-GBD is limited by contraindications such as large hepatic masses, significant ascites, and coagulopathy, and some critically ill patients cannot be transferred for PT-GBD or EUS-GBD. This case series demonstrates that bedside EUS-GBD in the ICU is technically feasible and safe for critically ill patients who are unsuitable for other interventions. Three cases involving severely ill patients successfully underwent bedside EUS-GBD with initial post-procedure improvement. Unfortunately, all patients eventually required comfort care due to their severe underlying conditions. These cases highlight EUS-GBD as an effective bedside option for gallbladder drainage in ICU patients when supported by multidisciplinary teams. Further research could confirm its expanded role in managing high-risk patients in intensive care.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"99-103"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical pilot trial of an artificial intelligence-driven smart phone application of bowel preparation for colonoscopy: a randomized clinical trial.","authors":"Huang Zhong, Cong Hou, Zhong Huang, Xinlian Chen, Yan Zou, Han Zhang, Tingyu Wang, Lan Wang, Xiangbing Huang, Yongfeng Xiang, Ming Zhong, Mingying Hu, Dongmei Xiong, Li Wang, Yuanyuan Zhang, Yan Luo, Yuting Guan, Mengyi Xia, Xiao Liu, Jinlin Yang, Tao Gan, Wei Wei, Honghan Chen, Hang Gong","doi":"10.1080/00365521.2024.2443520","DOIUrl":"10.1080/00365521.2024.2443520","url":null,"abstract":"<p><strong>Background: </strong>High-quality bowel preparation is paramount for a successful colonoscopy. This study aimed to explore the effect of artificial intelligence-driven smartphone software on the quality of bowel preparation.</p><p><strong>Methods: </strong>Firstly, we utilized 3305 valid liquid dung images collected <i>via</i> mobile phones as training data. the most effective model was employed on mobile phones to evaluate the quality of bowel preparation. Secondly, From May 2023 to September 2023, colonoscopy patients were randomly assigned to two groups - the AI group (<i>n</i> = 116) and the control group (<i>n</i> = 116) - using a randomized, controlled, endoscopist-blinded method. We compared the two groups in terms of Boston Bowel Preparation Scale (BBPS) scores, polyp detection rate, adverse reaction rate, and factors related to bowel preparation quality. The primary endpoint was the percentage of patients who achieved a BBPS ≥6 among those who effectively utilized the smartphone software.</p><p><strong>Results: </strong>EfficientNetV2 exhibited the highest performance, with an accuracy of 87%, a sensitivity of 83%, and an AUC of 0.86. In the patient validation experiment, the AI group had higher BBPS scores than the control group (6.78 ± 1.41 vs. 5.35 ± 2.01, <i>p</i> = 0.001) and showed an improvement in the detection rate (71.55% vs. 56.90%, <i>p</i> = 0.020) for polyps. Multifactor logistic analysis indicated that compliance with enema solution usage rules (OR: 5.850, 95% confidence interval: 2.022-16.923), total water intake (OR: 1.001, 95% confidence interval: 1.001-1.002), and AI software reminders (OR: 2.316, 95% confidence interval: 1.096-4.893) were independently associated with BBPS scores ≥6.</p><p><strong>Conclusion: </strong>Compared with traditional methods, the use of artificial intelligence combined with software to send reminders can lead to more accurate assessments of bowel preparation quality and an improved detection rate for polyps, thus demonstrating promising clinical value.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"116-121"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suboptimal adherence to a gluten-free diet in adults with both type 1 diabetes and celiac disease using urinary gluten immunogenic peptide measurement.","authors":"Kristine Vaage Hatlen, Therese Margrethe Lysell Lensnes, Christine Henriksen, Tore Julsrud Berg, Ingrid Nermoen, Knut Erik Aslaksen Lundin","doi":"10.1080/00365521.2024.2442688","DOIUrl":"10.1080/00365521.2024.2442688","url":null,"abstract":"<p><strong>Objectives: </strong>Concurrent type 1 diabetes (T1D) and celiac disease (CeD) pose challenges in insulin dosage adjustments and gluten-free dietary adherence. Urine testing for gluten immunogenic peptides (GIP) is a new method to detect gluten exposure within the last 3-12 h. Our aims were to compare gluten-free dietary adherence between T1D + CeD and CeD individuals and evaluate urinary GIP testing in an outpatient setting.</p><p><strong>Materials and methods: </strong>This observational cross-sectional study included three adult groups: (1) T1D and CeD, (2) CeD only, and (3) T1D only. T1D participants were recruited from outpatient clinics, the CeD group via social media. One urine sample (12 pm-7 pm) was analyzed using a qualitative immunographic GIP test. CeD participants completed 'Celiac Dietary Adherence Test' (CDAT) and 'Celiac Symptom Index' (CSI) questionnaires. IgA anti-transglutaminase 2 (IgA-TG2) and IgG anti-deamidated gliadin (IgG-DGP) serology were also analyzed.</p><p><strong>Results: </strong>197 participants, mean (SD) age 43 (15) years, were included. Female percentages were: CeD: 90%, T1D + CeD: 64%, and T1D: 47%. Positive urinary GIP was found in 15% (14/96) of T1D + CeD and 0% (0/50) of CeD (<i>p</i> = 0.002). As expected, most T1D only participants had positive urinary GIP (86%, 44/51). CDAT and CSI scores did not differ between T1D + CeD and CeD groups. Positive IgA-TG2 and/or IgG-DGP levels were found in 12% of T1D + CeD and 6% of CeD participants (<i>p</i> = 0.38).</p><p><strong>Conclusions: </strong>A single GIP urine test revealed higher gluten exposure in T1D + CeD versus CeD only, questioning dietary adherence in this population. Urinary GIP tests can be useful for clinical follow-up.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"28-36"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eradication of Helicobacter pylori by a potassium-competitive acid blocker alone?","authors":"Helge Waldum, Reidar Fossmark","doi":"10.1080/00365521.2024.2444477","DOIUrl":"10.1080/00365521.2024.2444477","url":null,"abstract":"<p><strong>Aims: </strong><i>Helicobacter pylori (H. pylori)</i>, the dominating cause of gastric cancer, most often infects children initiating inflammation in the antral part and spreads orally to the oxyntic mucosa. Traditionally, eradication of <i>H. pylori</i> has been based upon a combination of antibiotics together with a proton pump inhibitor (PPI) to reduce gastric destruction of the antibiotics. Recently it has been shown that the more efficient inhibitors of acid secretion, the potassium-competitive acid blockers (PCABs) in combination with amoxicillin alone gave highly sufficient <i>H. pylori</i> eradication.</p><p><strong>Methods: </strong>To further elucidate the importance of gastric acidity we studied the literature for the connection between gastric acidity and the presence of <i>H. pylori</i>.</p><p><strong>Results: </strong>It is well-known that <i>H. pylori</i> is dependent of some acidity in the surroundings to neutralize NH₃ produced by its urease, explaining the loss of <i>H. pylori</i> in total oxyntic atrophy. With adequate dosing PCABs can induce almost complete anacidity for 24-h which probably is necessary for <i>H. pylori</i> eradication. Even a short period with hypergastrinemia may induce mutations in the target cell of gastrin, the enterochromaffin-like (ECL) cell which may contribute to the relatively short interval between <i>H. pylori</i> eradication and gastric cancer in the users of profound acid inhibitors.</p><p><strong>Conclusion: </strong>The use of PCABs alone dosed sufficiently seems promising for <i>H. pylori</i> eradication, but a combination with a gastrin antagonist would be preferable.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"10-12"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative factors predicting outcomes in patients with Perihilar cholangiocarcinoma undergoing curative resection-a 10-year single-center experience.","authors":"Hasan Ahmad Al-Saffar, Nicolai Schultz, Peter Nørrgaard Larsen, Eva Fallentin, Gro Linno Willemoe, Diana Elena Renteria Ramirez, Lucas Alexander Knøfler, Hans-Christian Pommergaard","doi":"10.1080/00365521.2024.2443515","DOIUrl":"10.1080/00365521.2024.2443515","url":null,"abstract":"<p><strong>Background: </strong>Perihilar cholangiocarcinoma (pCCA) has a 5-year overall survival (OS) ranging from 10-40%, following resection. However, prognostic models for postoperative outcomes are limited by long study timespan and variations in work-up. We investigated postoperative outcomes in patients resected for pCCA in a high-volume center with standardized work-up.</p><p><strong>Method: </strong>Patients resected with confirmed pCCA, between 2013 and 2023, were included. Cox-regression investigated association between postoperative factors and OS as well as disease-free survival (DFS).</p><p><strong>Results: </strong>Totally, 65 patients were resected for pCCA. The 1-, 3- and 5-year OS rates were 86.1%, 56.5% and 32.6% respectively. The 1-, 3- and 5-year DFS rates were 67.7%, 40.0% and 26.8%, respectively. Portal vein embolization (PVE) (HR 4.52 [CI 1.66-12.27], <i>p</i> = 0.003), lymph node metastasis (LNM) (HR 6.37 [CI 2.06-19.67], <i>p</i> = 0.001) and Clavien-Dindo (CD) ≥3a (HR 2.83 [CI 1.43-5.56], <i>p</i> = 0.002) were associated with inferior OS. Clavien-Dindo (CD) ≥3a (HR 2.10 [CI 1.05-4.22], <i>p</i> = 0.03) and T-stage >2 (HR 2.36 [CI 1.01, 5.05], <i>p</i> = 0.04) were associated with inferior and superior DFS, respectively.</p><p><strong>Conclusion: </strong>PVE, T-stage >2, LNM and CD ≥ III were associated with worse prognosis in resected pCCA. Research is needed to improve pre-operative detection of oncological features and patients with risk of major surgical complications.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"73-80"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of functional defecation disorder in patients with constipation based on colonic transit test: a retrospective study.","authors":"Xiaoyang Ren, Xiaoni Yan, Jiao Zhu, Shuixiang He, Yan Yin","doi":"10.1080/00365521.2024.2434637","DOIUrl":"10.1080/00365521.2024.2434637","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the diagnostic efficacy of colonic transit test (CTT) in cases of constipation associated with functional defecation disorders (FDD) within the Chinese population.</p><p><strong>Methods: </strong>A retrospective analysis was conducted involving 202 patients diagnosed with functional constipation, who underwent CTT, high-resolution anorectal manometry, and balloon expulsion test. Participants were categorized based on the Rome IV criteria, comprising 103 patients with FDD and 99 without. The study examined the symptomatic characteristics of both groups and assessed the diagnostic utility of CTT in identifying constipation with FDD.</p><p><strong>Results: </strong>The predominant symptom reported among individuals with chronic functional constipation was excessive straining, observed in 69.3% of cases. The incidence of hard stool passage and feelings of incomplete evacuation were significantly greater in the FDD group compared to the non-FDD group (47.6% vs. 31.3%, <i>p</i> = 0.018 and 50.5% vs. 25.3%, <i>p</i> = 0.001, respectively). The presence of three or more rectosigmoid (RS) residual markers and a transit index of 40% or greater demonstrated moderate diagnostic value for FDD, characterized by low sensitivity(44.7% and 47.6%) but high specificity(76.8% and 75.8%). The RS residual markers were effective in differentiating between FDD and normal transit constipation, but not effectively distinguish between FDD and slow transit constipation.</p><p><strong>Conclusions: </strong>The presence of RS residue serves primarily as an exclusionary criterion for diagnosing FDD. In cases of slow transit constipation, but not normal transit constipation, it is imperative to conduct multiple kinetic assessments to accurately differentiate between FDD and other types of constipation.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"13-19"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}