Prevalence of gastric epithelial neoplasm of fundic-gland mucosa lineage diagnosed by medical checkup findings and time-course changes.

Abstract

Background: This study was performed to investigate the prevalence of gastric epithelial neoplasm of fundic-gland mucosa lineage (GEN-FGML) and time-course changes in endoscopic findings in affected subjects who underwent an esophagogastroduodenoscopy (EGD) examination as part of an annual checkup.

Methods: A total of 39,292 EGD examinations (25,228 men, 14,034 women; mean age: 53.6 years) were performed between April 2016 and March 2024. The prevalence of GEN-FGML was analyzed, and time-course changes noted in endoscopic findings of diagnosed tumors were investigated by comparison with previous endoscopic images.

Results: During the study period, we identified 19 patients with 20 GEN-FGML diagnosed based on endoscopic and histological results, with a prevalence of 0.048%. Prevalence was not different between Helicobacter pylori-uninfected and -eradicated cases (0.050% and 0.051%, respectively). Endoscopy findings of 16 of these tumors for which time-course changes could be investigated (median observation period: 8.5 years) showed that 15 were unchanged in size in comparison with previous EGD findings, while one showed enlargement. In addition, three lesions diagnosed after H. pylori eradication were unchanged in size compared to before eradication.

Conclusions: The prevalence of GEN-FGML by screening EGD was 0.048%, with prevalence not different between H. pylori-uninfected and -eradicated subjects. Enlargement over time was not observed in almost all cases, and H. pylori infection status was considered not to influence changes in tumor size.