Schizophrenia Research最新文献

{"title":"Response to the Letter to the Editor “Reflections on a study of electroconvulsive therapy for clozapine-refractory schizophrenia” (Jolly et al. Schizophrenia Research, 267 (2024) 32-33)","authors":"Helio Elkis , Christoph U. Correll , Debora L. Melzer-Ribeiro","doi":"10.1016/j.schres.2025.01.003","DOIUrl":"10.1016/j.schres.2025.01.003","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 15-16"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive mental health interventions for people with schizophrenia: A scoping review","authors":"Catarina Nogueira ,&nbsp;Emanuel Dias Pereira ,&nbsp;Joana Catarina Ferreira Coelho ,&nbsp;Antonio Rafael Moreno-Poyato ,&nbsp;Carlos Alberto Cruz Sequeira","doi":"10.1016/j.schres.2025.01.009","DOIUrl":"10.1016/j.schres.2025.01.009","url":null,"abstract":"<div><h3>Background</h3><div>Promoting positive mental health is crucial for maintaining a healthy balance of mental well-being, both for individuals with and without mental health conditions, including schizophrenia.</div></div><div><h3>Objective</h3><div>To map interventions that promote positive mental health in individuals with schizophrenia.</div></div><div><h3>Methods</h3><div>We conducted a scoping review following Joanna Briggs Institute recommendations. Searches were performed on Scopus, MEDLINE and CINAHL Complete (via EBSCOhost), and RCAAP for grey literature. Papers that met the following criteria were included: published from September 1999 to May 2023; involving only individuals diagnosed with schizophrenia; focused on interventions that promote positive mental health; presenting interventions with defined objectives and duration; designed for individuals or groups.</div></div><div><h3>Results</h3><div>We identified 1111 potentially relevant records, which were screened by 2 independent researchers. 26 studies, published between 2004 and 2023 were found eligible. Most of the identified interventions were implemented in community-based settings (<em>n</em> = 22), in group formats (<em>n</em> = 20), with a total duration between 4 and 12 weeks (<em>n</em> = 20), session duration about 45–60 min (<em>n</em> = 13) and without <em>follow up</em> (<em>n</em> = 17). A significant number of interventions focused on improving interpersonal relationship capacity (<em>n</em> = 15) and personal satisfaction (<em>n</em> = 13). 9 interventions focused on enhancing autonomy, 3 on promoting self-control, 2 on problem-solving/self-actualization and 1 on promoting pro-social attitude.</div></div><div><h3>Conclusions</h3><div>This scoping review can contribute to improving the quality of care provided and optimizing health outcomes, enhancing the promotion of community health through increased knowledge in the field of positive mental health.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 40-56"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143041297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of family-based interventions for early psychosis: Carer and patient outcomes","authors":"John F.M. Gleeson ,&nbsp;Kelsey Ludwig ,&nbsp;Bryan J. Stiles ,&nbsp;Stefan Piantella ,&nbsp;Catharine McNab ,&nbsp;Sue Cotton ,&nbsp;Madeleine I. Fraser ,&nbsp;Mario Alvarez-Jimenez ,&nbsp;Amity Watson ,&nbsp;Elizabeth Fraser ,&nbsp;David L. Penn","doi":"10.1016/j.schres.2025.01.006","DOIUrl":"10.1016/j.schres.2025.01.006","url":null,"abstract":"<div><h3>Background</h3><div>Previous reviews have indicated that family interventions in early psychosis are beneficial for patients and family caregivers. Given recent developments in research and service provision an updated review is warranted.</div></div><div><h3>Methods</h3><div>We conducted a systematic review and meta-analysis of family intervention trials in the first 5 years after psychosis onset. We identified randomized controlled trials that reported outcomes for family members and extracted available outcomes in relation to identified patients.</div></div><div><h3>Results</h3><div>We screened 8737 abstracts and 177 full text papers, resulting in 36 for extraction. We found significant pooled treatment effects for family interventions for carer psychological distress (Hedges <em>g</em> = 0.35), carer burden (Hedges <em>g</em> = −0.68), positive and negative carer appraisals (Hedges <em>g</em> = 0.20, <em>g</em> = −0.21), and components of expressed emotion (critical comments and emotional overinvolement) compared with care as usual (Hedges <em>g</em> = −0.81, −0.92). For patients we found a moderate pooled effect for reduced rates of hospitalization compared with care as usual (Hedges <em>g</em> = −0.52). The effects for carer burden were maintained for studies in China, but not in other settings combined. The effects for hospitalization were maintained for multicomponent interventions but not when psychoeducation was the sole component. There was evidence of significant study heterogeneity. Risk of bias assessment indicated that deviations from intended treatment were most frequently rated as the weakest domain.</div></div><div><h3>Conclusions</h3><div>Family interventions for early psychosis benefit both family carers and their relatives diagnosed with psychosis when compared with usual care. Future research should further clarify the effective components and investigate innovations in cultural sensitivity, peer support and digital modes.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 57-78"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143041300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A mixed-methods study exploring the benefits, drawbacks, and utilization of data in care: Findings from the EPI-CAL early psychosis learning health care network","authors":"Sabrina Ereshefsky ,&nbsp;Regina Gemignani ,&nbsp;Mark Savill ,&nbsp;Katherine C. Sanford ,&nbsp;Lindsay M. Banks ,&nbsp;Valerie L. Tryon ,&nbsp;Kathleen E. Nye ,&nbsp;Katherine M. Pierce ,&nbsp;Madison J. Miles ,&nbsp;Chelyah Miller ,&nbsp;Khanh Linh H. Nguyen ,&nbsp;Nitasha Sharma ,&nbsp;Merissa Kado-Walton ,&nbsp;Christopher K. Hakusui ,&nbsp;Leigh Smith ,&nbsp;Viviana E. Padilla ,&nbsp;Amanda P. McNamara ,&nbsp;Maliha Safdar ,&nbsp;Andrew J. Padovani ,&nbsp;Rachel L. Loewy ,&nbsp;Tara A. Niendam","doi":"10.1016/j.schres.2025.01.018","DOIUrl":"10.1016/j.schres.2025.01.018","url":null,"abstract":"<div><div>Using data collected in routine care delivery to inform treatment is a key feature of a learning health system (LHS). In this study, we explored the experiences of service users and providers adopting measurement-based care (MBC) in early psychosis (EP) specialty care settings. Qualitative interviews were conducted with 32 providers and 12 service users across 18 programs in the Early Psychosis Intervention Network of California (EPI-CAL). These findings were compared with quantitative data from Beehive, EPI-CAL's data collection and review application. Regarding the clinical benefits of MBC in EP, three broad themes were identified – supporting safety monitoring and response, the assessment process, and delivery of psychotherapy. Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation Outside of direct clinical care, Beehive was considered to support clinical supervision and external reporting, while service users reported data collection facilitated selfreflection. In the quantitative Beehive application data collected from 23 EP programs, high utilization of the safety alert system was evident (349 alerts in total, of which 338 [96.85 %] were resolved at a median of 2.03 days). However, service users' key survey data was only reviewed by assigned providers in 32.22 % (142 of 441) of cases. While providers and service users saw many benefits to Beehive, utilization was highly inconsistent outside of the alert system. Going forward, further consideration of how best to support EP providers to consistently use data in care is necessary to maximize the utility of the LHS approach and positively impact outcomes.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 157-166"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of loneliness and living alone on negative symptoms in severe mental illness: An electronic health record data analysis","authors":"Dulce E. Alarcón-Yaquetto ,&nbsp;Robert Stewart ,&nbsp;Gayan Perera ,&nbsp;Mariana Pinto da Costa","doi":"10.1016/j.schres.2025.01.021","DOIUrl":"10.1016/j.schres.2025.01.021","url":null,"abstract":"<div><div>Important changes in symptom profiles occur early in the course of severe mental illness (SMI) after its clinical presentation. The emergence of negative symptoms is of particular concern for later function, and these may well have strong links with loneliness and poor social support which are also recognised to be common. However, the impact of loneliness and social isolation on symptoms and treatment outcomes remains unclear. To explore this, we conducted a retrospective observational analysis using data from electronic health records of a large mental health provider in London. Loneliness, living alone and symptoms of SMI were extracted using bespoke natural language processing algorithms. Symptoms were grouped into five domains: positive, negative, disorganised, manic, and catatonic, and were measured at diagnosis and 12 months following the initial SMI diagnosis. Loneliness and living alone were operationalised as binary variables, based on any recording during the follow-up period. A total of 8237 records were analysed. The prevalence of loneliness was 20.4 % and living alone 19.9 %, with only 6.8 % recorded with both. Recorded loneliness was associated with an increase in negative symptoms over the follow-up period, in models adjusted by sociodemographic variables and pharmacological treatment [OR 1.28 (1.11–1.48), <em>p</em> = 0.001], as was living alone to a weaker extent [OR 1.18 (1.02–1.36), <em>p</em> = 0.030]. No associations were found between either exposure variable and changes in symptoms from other domains. Given that negative symptoms are disabling and challenging to treat, these results highlight the importance of effective interventions to enhance social support in SMI over the early post-diagnostic period.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 196-201"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143300457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial mechanics in schizophrenia and bipolar disorder: A gap to fill","authors":"Andrea Faggiano ,&nbsp;Elisa Gherbesi ,&nbsp;Stefano Carugo ,&nbsp;Guido Grassi ,&nbsp;Marijana Tadic ,&nbsp;Cesare Cuspidi","doi":"10.1016/j.schres.2025.01.023","DOIUrl":"10.1016/j.schres.2025.01.023","url":null,"abstract":"<div><h3>Background</h3><div>Evidence on subclinical cardiac organ damage and, particularly on myocardial deformation, detected by speckle tracking echocardiography (STE), in patients with schizophrenia and bipolar disorder free from known cardiac disease is scanty. The aim of the present systematic review was investigate whether global longitudinal strain (GLS) could be a more sensitive index of systolic dysfunction than left ventricular ejection fraction (LVEF) in this setting, after having preliminary focused on LV structural and functional changes by standard echocardiography or magnetic resonance imaging (MRI).</div></div><div><h3>Methods</h3><div>To identify eligible studies targeting GLS in patients with schizophrenia and bipolar disorder systematic searches were conducted across bibliographic databases (Pub-Med, OVID, EMBASE and Cochrane library) following the PRISMA guidelines, from inception up to August 31, 2024.</div></div><div><h3>Results</h3><div>Six studies focusing on GLS including a total of 535 patients with schizophrenia (<em>n</em> = 185) or bipolar disorder (<em>n</em> = 350), and 153 healthy controls were considered for the review. Four studies compared GLS values of patients with schizophrenia and bipolar disorder with healthy controls and the other two studies evaluated the impact of antipsychotic therapy on this index of myocardial deformation. Overall, GLS emerged as a more sensitive index in assessing early systolic dysfunction than LVEF as well as the effects of antipsychotic drugs on systolic function.</div></div><div><h3>Conclusions</h3><div>The evaluation of LV mechanics in patients with schizophrenia and bipolar disorder is underused despite the fact that could unmask subclinical systolic dysfunction better than LVEF. Thus, the role of STE in detecting early LV systolic dysfunction in this clinical setting needs to be further investigated in future studies.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 243-249"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143386692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creating a collaborative culture of learning within a network of community mental health early psychosis programs in Texas","authors":"Molly A. Lopez ,&nbsp;Samantha J. Reznik ,&nbsp;Vanessa V. Klodnick ,&nbsp;Deborah Cohen ,&nbsp;Neely Myers ,&nbsp;Justin F. Rousseau ,&nbsp;Nazan Aksan ,&nbsp;Eliel de Oliveira ,&nbsp;Stephen M. Strakowski","doi":"10.1016/j.schres.2024.12.009","DOIUrl":"10.1016/j.schres.2024.12.009","url":null,"abstract":"<div><div>Learning Health Systems (LHSs) promise meaningful health care improvement through the ongoing use of data, including the lived experience of diverse constituents, such as people participating in and providing services. Most LHSs operate within a specific healthcare system, typically hospital-based, under a common electronic health record (EHR) and management structure. The Early Psychosis Intervention Network in Texas (EPINET-TX) is a novel case study of a developing LHS across 16 independent community mental health clinics operating state-funded coordinated specialty care (CSC) programs for early psychosis. EPINET-TX is a partnership among a multidisciplinary research hub and state and local entities. Grounded in participatory research frameworks, multiple strategies were utilized to align partners around learning goals, build data use competencies, enhance researchers' understanding of program context, and cultivate a continuous performance improvement mindset. Key strategies for developing a LHS culture included a) intentionally building collaborative relationships, b) establishing shared values and governance, c) collaborating in research and change-focused workgroups, and d) sharing learning and growth experiences. For CSC programs operating within the public mental health system, the LHS framework provides a promising model to foster quality improvement, innovation, and action-oriented participatory research.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 1-7"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing the relationship between personality dimensions and psychosis-specific clinical characteristics","authors":"Youjin Jenny Jang ,&nbsp;Walid Yassin ,&nbsp;Raquelle Mesholam-Gately ,&nbsp;Elliot S. Gershon ,&nbsp;Sarah Keedy ,&nbsp;Godfrey G. Pearlson ,&nbsp;Carol A. Tamminga ,&nbsp;Jennifer McDowell ,&nbsp;David A. Parker ,&nbsp;Kodiak Sauer ,&nbsp;Matcheri S. Keshavan","doi":"10.1016/j.schres.2025.01.002","DOIUrl":"10.1016/j.schres.2025.01.002","url":null,"abstract":"<div><h3>Background</h3><div>Past studies associating personality with psychosis have been limited by small nonclinical samples and a focus on general symptom burden. This study uses a large clinical sample to examine personality's relationship with psychosis-specific features and compare personality dimensions across clinically and neurobiologically defined categories of psychoses.</div></div><div><h3>Methods</h3><div>A total of 1352 participants with schizophrenia, schizoaffective disorder, and bipolar with psychosis, as well as 623 healthy controls (HC), drawn from the Bipolar-Schizophrenia Network for Intermediate Phenotypes (BSNIP-2) study, were included. Three biomarker-derived biotypes were used to separately categorize the probands. Mean personality factors (openness, conscientiousness, extraversion, agreeableness, and neuroticism) were compared between HC and proband subgroups using a generalized linear model. A robust linear regression was utilized to determine personality differences across biotypes and diagnostic subgroups. Associations between personality factors and cognition were determined through Pearson's correlation. A canonical correlation was run between the personality factors and general functioning, positive symptoms, and negative symptoms to delineate the relationship between personality and clinical outcomes of psychosis.</div></div><div><h3>Results</h3><div>There were significant personality differences between the proband and HC groups across all five personality factors. Overall, the probands had higher neuroticism and lower extraversion, agreeableness, conscientiousness, and openness. Openness showed the greatest difference across the diagnostic subgroups and biotypes, and greatest correlation with cognition. Openness, agreeableness, and extraversion had the strongest associations with symptom severity.</div></div><div><h3>Conclusions</h3><div>Individuals with psychotic disorders have different personality traits compared to HC. In particular, openness may be relevant in distinguishing psychosis-specific phenotypes and experiences, and associated with biological underpinnings of psychosis, including cognition. Further studies should identify potential causal factors and mediators of this relationship.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 88-96"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binaural hearing impairment in patients with schizophrenia: A multicenter study","authors":"Lei Liu ,&nbsp;Yu Xia ,&nbsp;Liangjie Chen ,&nbsp;Feng Zou ,&nbsp;Shenglin She ,&nbsp;Liang Li ,&nbsp;Yingjun Zheng","doi":"10.1016/j.schres.2025.01.013","DOIUrl":"10.1016/j.schres.2025.01.013","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 175-177"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive function at first episode in patients subsequently developing treatment-resistant schizophrenia","authors":"Juan M. Aguirre ,&nbsp;Camila Díaz Dellarossa ,&nbsp;Daniella Barbagelata ,&nbsp;Javiera Vásquez ,&nbsp;Cristián Mena ,&nbsp;Ángeles Tepper ,&nbsp;Juan Pablo Ramírez-Mahaluf ,&nbsp;David Aceituno ,&nbsp;Rubén Nachar ,&nbsp;Juan Undurraga ,&nbsp;Alfonso González-Valderrama ,&nbsp;Nicolas A. Crossley","doi":"10.1016/j.schres.2025.01.017","DOIUrl":"10.1016/j.schres.2025.01.017","url":null,"abstract":"<div><h3>Background</h3><div>Research on cognitive functions in treatment-resistant schizophrenia (TRS) has focused on chronic patients, complicating the distinction between disease-related deficits from those influenced by chronicity or antipsychotic exposure. Identifying early cognitive differences could offer insights into the nature of TRS cognitive performance and serve as potential markers of treatment resistance.</div></div><div><h3>Methods</h3><div>Cohort study of 81 first-episode schizophrenia patients from Chile. Patients were followed-up and classified as TRS if they met TRRIP criteria or were prescribed clozapine at any point. 57 healthy controls were recruited for group comparisons. Cognitive performance was assessed using the MATRICS Consensus Cognitive Battery.</div></div><div><h3>Results</h3><div>51 patients were allocated to the treatment-responsive group (TRESP) and 30 to the TRS sample. Multivariable analyses controlling for age and sex revealed a worse TRS performance in processing speed, verbal fluency, attention/vigilance and working memory (<em>p</em> values &lt;0.05). After multiple comparison corrections, only speed of processing remained significant. When accounting for symptom severity, antipsychotic dose and duration of untreated psychosis (DUP), TRS subjects still showed significantly lower processing speed (BACS, <em>p</em> = 0.036; TMT-A, <em>p</em> = 0.027), which was not significant after correcting for multiple comparisons.</div></div><div><h3>Discussion</h3><div>TRS patients show slower processing speed compared to TRESP already during first episode, that is not entirely driven by symptom severity, antipsychotic dose and DUP. Processing speed emerges as an early deficit that could aid in the timely identification of patients on a treatment resistance trajectory and facilitate the prompt implementation of treatments such as clozapine.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 178-184"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}