Unveiling distinct representations of P3a in schizophrenia through two-stimulus and three-stimulus auditory oddball paradigms

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research Pub Date : 2025-03-01 DOI:10.1016/j.schres.2025.03.004

Chenguang Jiang , Jun Wang , Yifan Sun , Shuping Tan , Shaun M. Percell , the GRINS consortium, Zhenhe Zhou , Jen Q. Pan , Mei-Hua Hall

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引用次数: 0

Abstract

Background

P3a event-related potential (ERP) is considered a potential biomarker for schizophrenia (SZ), can be elicited through both passive two-stimulus and active three-stimulus auditory oddball paradigms. While both types of P3a reflect involuntary attention shifts, the nuanced understanding of what P3a represents in different contexts is important and rarely studied. This study aims to examine correlations between P3a ERPs elicited from different paradigms and associations of each P3a with cognitive function, clinical symptoms, and antipsychotic medication.

Methods

Our sample included 178 SZ patients and 127 healthy controls (HC). Data on two-stimulus paradigm, three-stimulus oddball paradigm, Chinese version of MATRICS Consensus Cognitive Battery (MCCB), symptom severity, and medication use were collected.

Results

In both paradigms, SZ group's P3a amplitude was significantly reduced compared to HC's (both p < 0.05). P3a evoked by the two-stimulus paradigm and the three-stimulus paradigm were not correlated (r = −0.06, p = 0.661). Three-stimulus paradigm-P3a was significantly correlated with attention/vigilance (r = 0.27, p = 0.017) in SZ, and with working memory (r = 0.39, p = 0.001) and overall MCCB score (r = 0.25, p = 0.042) in HC. Additionally, the two-stimulus paradigm-P3a correlated with olanzapine equivalent antipsychotic dose (r = −0.26, p = 0.022).

Conclusions

Our findings offer new insights into the role of P3a in clinical research. P3a ERPs from different paradigms may represent functionally distinct components. The context in which the P3a is elicited should be taken into account when discussing its functional or neurocognitive significance.

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通过双刺激和三刺激听觉怪异范式揭示P3a在精神分裂症中的不同表征

p3a事件相关电位（event- correlation potential， ERP）被认为是精神分裂症（SZ）的潜在生物标志物，它可以通过被动双刺激和主动三刺激听觉怪异范式被激发。虽然两种类型的P3a都反映了不自觉的注意力转移，但对P3a在不同背景下代表什么的细致理解很重要，但很少被研究。本研究旨在探讨不同范式引发的P3a erp之间的相关性，以及每种P3a与认知功能、临床症状和抗精神病药物的关联。方法选取SZ患者178例，健康对照127例。收集双刺激范式、三刺激古怪范式、中文版matrix共识认知电池（MCCB）、症状严重程度、用药情况等数据。结果在两种范式中，SZ组的P3a振幅均显著低于HC组(p <；0.05)。双刺激范式和三刺激范式诱发的P3a不相关（r = - 0.06, p = 0.661）。三刺激范式p3a与SZ组注意/警觉性显著相关（r = 0.27, p = 0.017），与HC组工作记忆显著相关（r = 0.39, p = 0.001），与MCCB总分显著相关（r = 0.25, p = 0.042）。此外，双刺激范式- p3a与奥氮平等效抗精神病药物剂量相关（r = - 0.26, p = 0.022）。结论本研究结果为P3a在临床研究中的作用提供了新的认识。来自不同范式的P3a erp可能代表功能不同的组件。在讨论P3a的功能或神经认知意义时，应考虑其产生的背景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Schizophrenia Research 医学-精神病学

CiteScore

7.50

自引率

8.90%

发文量

429

审稿时长

10.2 weeks

期刊介绍： As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership! Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue. The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.