Schizophrenia Research最新文献

{"title":"Hippocampus subfield volume reductions in treatment-resistant schizophrenia","authors":"Alexandra Fortier , Andràs Tikàsz , Maria Athanassiou , Inès Zouaoui , Nancy Légaré , Emmanuel Stip , Olivier Lipp , Alexandre Dumais , Stéphane Potvin","doi":"10.1016/j.schres.2025.04.006","DOIUrl":"10.1016/j.schres.2025.04.006","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DLG2 rs11607886 polymorphism associated with schizophrenia and precuneus functional changes","authors":"HanYu Zhu ,&nbsp;Zhaoyang Wu ,&nbsp;Junxiao Wang ,&nbsp;Enhui Zhang ,&nbsp;Sen Zhang ,&nbsp;Yongfeng Yang ,&nbsp;Wenqiang Li ,&nbsp;Han Shi ,&nbsp;Ge Yang ,&nbsp;Luxian Lv ,&nbsp;Yan Zhang","doi":"10.1016/j.schres.2025.04.004","DOIUrl":"10.1016/j.schres.2025.04.004","url":null,"abstract":"<div><h3>Background and hypothesis</h3><div>Schizophrenia (SZ) is a severe mental disorder with high heritability. <em>DLG2</em> encodes the postsynaptic scaffolding protein DLG2 (PSD93, Postsynaptic Density Protein 93), and its variants were associated with an increased risk of SZ. However, the role of <em>DLG2</em> locus variation in SZ remains elusive. This study aims to investigate the association between <em>DLG2</em> gene polymorphisms and SZ susceptibility and the relationship between <em>DLG2</em> and altered brain function and clinical symptoms in SZ patients.</div></div><div><h3>Study design</h3><div>Single nucleotide polymorphisms (SNPs) rs11607886 and rs7479949 were genotyped in 350 SZ patients and 407 healthy controls (HCs). 47 SZ patients and 79 HCs were genotyped into two groups: the risk A allele carrier group and the GG-pure group. Functional magnetic resonance imaging (fMRI) indices were further analyzed. Subsequently, data from different brain regions were correlated with clinical symptom assessment.</div></div><div><h3>Study results</h3><div><em>DLG2</em> rs11607886 was significantly associated with SZ. Significant main effects were found in the ALFF and ReHo, especially for the left precuneus gyrus (PCu). A significant interaction between genotype and diagnosis had a significant effect on FC, which was increased between the left PCu and the right middle temporal gyrus in carriers of the A allele with SZ (<em>r</em> = −0.336, <em>P</em>_un-corrected = 0.042) and negatively correlated with spatial breadth scores (<em>r</em> = 0.444, <em>P</em>_{FDR-corrected} = 0.002).</div></div><div><h3>Conclusions</h3><div>The rs11607886 polymorphism in <em>DLG2</em> may influence the pathogenesis of SZ and have potential effects on cognitive function. The present study emphasizes <em>DLG2</em> as a candidate gene for SZ and suggests an important role for PCu in SZ.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Pages 50-58"},"PeriodicalIF":3.6,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding: Dynamic network analysis of schizophrenia spectrum traits, affective symptoms, and social functioning—Opportunities and challenges","authors":"Chao Lu ,&nbsp;Da Huang ,&nbsp;Jiaxin Su ,&nbsp;Zhaoxia Huang","doi":"10.1016/j.schres.2025.04.008","DOIUrl":"10.1016/j.schres.2025.04.008","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Pages 48-49"},"PeriodicalIF":3.6,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a risk assessment model for treatment-resistant schizophrenia: The role of niacin receptor GPR109A and prostaglandin receptors DP1, EP2, and EP4 in the niacin-induced flushing pathway","authors":"Chi-Wei Chiu ,&nbsp;Bao-Yu Chen ,&nbsp;Jin-Jia Lin ,&nbsp;Huai-Hsuan Tseng ,&nbsp;Chih-Chun Huang ,&nbsp;Tzu-Yun Wang ,&nbsp;Fong-Lin Jang ,&nbsp;Chi-Yu Yao ,&nbsp;Wei-Hung Chang ,&nbsp;Po-See Chen ,&nbsp;Sheng-Hsiang Lin","doi":"10.1016/j.schres.2025.04.003","DOIUrl":"10.1016/j.schres.2025.04.003","url":null,"abstract":"<div><div>Schizophrenia patients show attenuated niacin flush responses compared to healthy controls (HC) attributed to abnormalities in the niacin-induced flushing pathway. Underlying immunological abnormalities may reduce the niacin receptor GPR109A's response and implicated in treatment-resistant schizophrenia (TRS). This pathway involves GPR109A and the downstream vasodilatory prostaglandins (PGs), PGD₂ and PGE₂, along with their receptors DP₁, EP₂, and EP₄, contributing to vasodilation and neuroprotection. We hypothesized that the niacin receptor GPR109A, PGs, and their receptors play a significant role in the pathogenesis of TRS. We aimed to investigate GPR109A, DP₁, PGD₂, PGE₂, EP₂, and EP₄ as potential biomarkers for identifying TRS and construct a risk assessment model for TRS. We recruited 58 TRS, 67 NTRS patients, and 115 HC. We observed significant differences in niacin flush responses and expression levels of GPR109A, PGE₂, DP₁, EP₂, and EP₄ between the schizophrenia and HC groups. TRS group exhibited lower expression levels of GPR109A, DP₁, EP₂, and EP₄ than NTRS group. Receiver operating characteristic curve analysis combining the six markers for schizophrenia versus HC yielded an area under the curve (AUC) of 0.98, whereas an analysis combining the four markers for TRS versus NTRS yielded an AUC of 0.91. Niacin-induced flushing signaling cascade enrichment is linked to the intensity of the inflammatory response, with associated mediators and their receptor affinities potentially regulating pharmacological effects. These findings suggest that the niacin receptor GPR109A and PG receptors DP₁, EP₂, and EP₄, which are involved in the niacin-induced flushing pathway, may serve as biomarkers for predicting TRS.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Pages 30-38"},"PeriodicalIF":3.6,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global evaluation of the impact of food fortification with folic acid on rates of schizophrenia","authors":"Samantha Yoo ,&nbsp;Azita Montazeri ,&nbsp;Helene McNulty ,&nbsp;Monique Potvin Kent ,&nbsp;Derrick Bennett ,&nbsp;Julian Little","doi":"10.1016/j.schres.2025.04.007","DOIUrl":"10.1016/j.schres.2025.04.007","url":null,"abstract":"<div><h3>Background</h3><div>Low folate status is one of the multiple factors thought to contribute to the development of schizophrenia. As of 2023, over 70 countries have implemented mandatory fortification of foods with folic acid, a public health measure aimed at reducing neural tube defects; however, the impact of such policy on schizophrenia has not been comprehensively investigated.</div></div><div><h3>Method</h3><div>We assessed the impact of mandatory folic acid fortification on changes in the schizophrenia rates in 194 jurisdictions between 1990 and 2019 using publicly available data. We used weighted regression models adjusted for sociodemographic and sociopolitical factors, experience of natural disasters, and baseline schizophrenia rate.</div></div><div><h3>Results</h3><div>Age-adjusted prevalence and incidence of schizophrenia increased marginally between 1990 and 2019. In all geographic regions, schizophrenia prevalence and incidence per 100,000 positively correlated with countries' sociodemographic index and were lower with fortification. Schizophrenia burdens were higher among males compared to females. Lower prevalence and incidence of schizophrenia were associated with having mandatory fortification with modest magnitudes. Duration of fortification or the fortification dose did not appear to have a strong impact. However, in the 15–39 year age-group, both mandatory fortification (β = −13·14 (−22·60, −3·68)) and duration of fortification (β = −0·82 (−1·40, −0·23)) were significantly associated with lower schizophrenia with larger magnitude in both sexes. The highest dose tertile was reported to have the lowest incidence and the smallest increase in prevalence in this age-group.</div></div><div><h3>Conclusion</h3><div>Folic acid fortification may be a beneficial intervention in lowering schizophrenia among adolescents and young adults.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Pages 39-47"},"PeriodicalIF":3.6,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143814772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of differentially expressed genes in schizophrenia based on bioinformatics and corresponding mRNA expression levels","authors":"Meiting Liu ,&nbsp;Shiqi Tian ,&nbsp;Xiaoying Liu ,&nbsp;Huaxia Zhang ,&nbsp;Zhiwei Tang ,&nbsp;Zhaowei Teng ,&nbsp;Fang Liu","doi":"10.1016/j.schres.2025.04.002","DOIUrl":"10.1016/j.schres.2025.04.002","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to use bioinformatics analysis to identify differentially expressed genes (DEGs) involved in the pathogenesis of schizophrenia and validate their mRNA expression levels through real-time quantitative PCR (qPCR).</div></div><div><h3>Material/methods</h3><div>Datasets from the publicly available Gene Expression Omnibus (GEO) database were analyzed using R software to identify DEGs. Functional enrichment analyses, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, were conducted. A protein–protein interaction (PPI) network was constructed using Cytoscape software to identify key genes with notable expression changes. The expression levels of these key genes were subsequently validated in schizophrenia patients using qPCR to assess potential susceptibility genes.</div></div><div><h3>Results</h3><div>In total, 813 DEGs were identified, with six key genes highlighted through GO analysis and PPI network screening. Among these, HDAC1, UBA52, and FYN demonstrated statistically significant differences in mRNA expression between schizophrenia patients and healthy controls (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>This study identified several DEGs potentially linked to the pathogenesis of schizophrenia, suggesting that HDAC1, UBA52, and FYN could serve as candidate susceptibility genes and diagnostic biomarkers. These findings provide new insights and directions for future schizophrenia research.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Pages 22-29"},"PeriodicalIF":3.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avolition predicts variability in optimal risk-taking in early psychosis","authors":"Pooja K. Patel ,&nbsp;Melanie Blair Thies ,&nbsp;Ashley Moyett ,&nbsp;Sophie Arkin ,&nbsp;Danielle Currin ,&nbsp;Pamela DeRosse ,&nbsp;Katherine H. Karlsgodt","doi":"10.1016/j.schres.2025.04.001","DOIUrl":"10.1016/j.schres.2025.04.001","url":null,"abstract":"<div><h3>Background</h3><div>Adolescence and early adulthood are associated with increased risk-taking, with a growing understanding that risk-taking may be adaptive during this developmental period. In psychosis, failure to appropriately engage in optimal risk-taking due to altered reward processing may contribute to poor social and role functioning. We investigated differences in optimal risk-taking in early psychosis (EP), as well as the relationship between optimal risk-taking and the negative symptom of avolition.</div></div><div><h3>Methods</h3><div>Fifty-six EP participants and 52 healthy controls (HC) completed a modified version of the Balloon Analog Risk Task (BART). In the BART, individuals inflated a virtual balloon to gain points; if the balloon exploded, no points were gained. We manipulated degree of risk, such that trials were low-risk (high probability of reward, low probability of punishment) or high-risk (low probability of reward, high probability of punishment). We investigated differences between EP and HC in (1) risk-propensity on low- and high-risk trials, (2) total adverse outcomes, and (3) behavior changes following punishment.</div></div><div><h3>Results</h3><div>There were no significant differences between EP and HC on any BART metrics; however, in EP, the negative symptom of avolition was associated with reduced risk-propensity on low-risk trials and reduced risk-taking immediately following punishment on low-risk trials. In the high-risk condition, avolition was not associated with risk-propensity, number of adverse outcomes, or behavior following punishment.</div></div><div><h3>Conclusions</h3><div>These results suggest that risk-taking and response to punishment in high-risk situations may be preserved in psychosis, and that in lower-risk situations that allow for greater variability, behavior may be moderated by negative symptom severity.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Pages 15-21"},"PeriodicalIF":3.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived social support in parents with schizophrenia or bipolar disorder and their co-parents: The Danish high risk and resilience study VIA 7","authors":"Aja Neergaard Greve ,&nbsp;Nicoline Hemager ,&nbsp;Geneviève Piché ,&nbsp;Birgitte Klee Burton ,&nbsp;Ditte Ellersgaard ,&nbsp;Camilla Jerlang Christiani ,&nbsp;Katrine S. Spang ,&nbsp;Kerstin J. Plessen ,&nbsp;Jens Richardt Møllegaard Jepsen ,&nbsp;Ole Mors ,&nbsp;Merete Nordentoft ,&nbsp;Anne A.E. Thorup","doi":"10.1016/j.schres.2025.03.001","DOIUrl":"10.1016/j.schres.2025.03.001","url":null,"abstract":"<div><h3>Background</h3><div>Lack of social support is a risk factor for symptom recurrence and poor prognosis for individuals with severe mental disorders. Compared to healthy populations, individuals with schizophrenia or bipolar disorder are more likely to perceive lower levels of social support. Evidence is needed on perceived social support in parents with schizophrenia or bipolar disorder and their co-parents.</div></div><div><h3>Methods</h3><div>Based on data from a population-based cohort study, The Danish High Risk and Resilience Study – VIA 7, we compared perceived social support measured with The Social Provisions Scale (SPS) in parents with schizophrenia (<em>n</em> = 148), their co-parents (<em>n</em> = 157), parents with bipolar disorder (<em>n</em> = 98), their co-parents (<em>n</em> = 89), and control parents (<em>n</em> = 359).</div></div><div><h3>Results</h3><div>We found lower levels of perceived social support in parents with schizophrenia and bipolar disorder compared with controls. Schizophrenia co-parents had lower levels of perceived social support compared to controls, but no difference was found between bipolar disorder co-parents and controls.</div></div><div><h3>Conclusions</h3><div>Low levels of perceived social support for these parents may pose an additional risk factor for their offspring in addition to the effects of genetic risk. Our results may inform future intervention studies and highlight the need for support for families with parental schizophrenia or bipolar disorder.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"279 ","pages":"Pages 137-143"},"PeriodicalIF":3.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HONE: A learning health system platform for advancing early intervention in first episode psychosis","authors":"Walter S. Mathis,&nbsp;Toni Gibbs-Dean,&nbsp;John D. Cahill,&nbsp;Vinod H. Srihari","doi":"10.1016/j.schres.2025.04.009","DOIUrl":"10.1016/j.schres.2025.04.009","url":null,"abstract":"<div><div>The emergence of psychosis in early adulthood necessitates rapid, specialized care to improve outcomes and reduce the duration of untreated psychosis. Early intervention services (EIS) for First Episode Psychosis (FEP) are exemplars of healthcare reform but face challenges in sustaining durable improvements across patients' lifetime illnesses. Learning Health Systems (LHS) present a transformative framework, integrating care delivery with continuous quality improvement and research. In this paper, we detail the development and evolution of the Health Outcomes Network and Education (HONE), a novel informatics platform designed to support an LHS for FEP.</div><div>HONE facilitates data harmonization, analytics, and visualization to drive quality improvement, leveraging user-centered design to engage clinicians and align with clinical workflows. The platform emphasizes evidence-based outcomes, integrating diverse data sources, including patient-reported outcomes, clinical assessments, and external datasets, within a harmonized repository. By employing a minimalist, question-based approach to data visualization, HONE delivers actionable insights that inform clinical practice while generating research questions to improve care.</div><div>We discuss key lessons from HONE's development, including the importance of user engagement, iterative refinement, and balancing standardization with site-specific flexibility. HONE has been successfully deployed across multi-site networks, demonstrating its scalability and adaptability to diverse healthcare settings. This paper highlights HONE's contributions to bridging the gap between knowledge and care, fostering bi-directional knowledge translation, and advancing mental health outcomes. Future efforts will focus on expanding HONE's reach, integrating predictive analytics, and evaluating its long-term impact on FEP care within the LHS framework.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Pages 1-9"},"PeriodicalIF":3.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single composite index of semantic behavior tracks symptoms of psychosis over time","authors":"Claudio Palominos ,&nbsp;Maryia Kirdun ,&nbsp;Amir H. Nikzad ,&nbsp;Michael J. Spilka ,&nbsp;Philipp Homan ,&nbsp;Iris E. Sommer ,&nbsp;Sunny X. Tang ,&nbsp;Wolfram Hinzen","doi":"10.1016/j.schres.2025.03.038","DOIUrl":"10.1016/j.schres.2025.03.038","url":null,"abstract":"<div><div>Semantic variables automatically extracted from spontaneous speech characterize anomalous semantic associations generated by groups with schizophrenia spectrum disorders (SSD). However, with the use of different language models and numerous aspects of semantic associations that could be tracked, the semantic space has become very high-dimensional, challenging both theoretical understanding and practical applications. This study aimed to summarize this space into a single composite semantic index and to test whether it can track diagnosis and symptom profiles over time at an individual level. The index was derived from a principal component analysis (PCA) yielding a linear combination of 117 semantic variables. It was tested in discourse samples of English speakers performing a picture description task, involving a total of 103 individuals with SSD and 36 healthy controls (HC) compared across four time points. Results showed that the index distinguished between SSD and HC groups, identified transitions from acute psychosis to remission and stabilization, predicted the sum of scores of the Thought, Language and Communication (TLC) index as well as subscores, capturing 65 % of the variance in the sum of TLC scores. These findings show that a single indicator meaningfully summarizes a shift in semantic associations in psychosis and tracks symptoms over time, while also pointing to variance unexplained, which is likely covered by other semantic and non-semantic factors.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"279 ","pages":"Pages 116-127"},"PeriodicalIF":3.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}