Schizophrenia Research最新文献

{"title":"Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence","authors":"Emma J. Carpendale ,&nbsp;Maddison C. Bell ,&nbsp;Alexis E. Cullen ,&nbsp;Hannah Dickson ,&nbsp;Ruth E. Roberts ,&nbsp;Helen L. Fisher ,&nbsp;Kristin R. Laurens","doi":"10.1016/j.schres.2025.07.001","DOIUrl":"10.1016/j.schres.2025.07.001","url":null,"abstract":"<div><div>Distinct patterns in the premorbid development of verbal and performance intelligence might differentiate the propensity for later illness among individuals putatively at risk for schizophrenia. This study applied linear mixed-effects models to four verbal and performance intelligence assessments gathered from a community sample of youth (<em>n</em> = 114) over ages 9–20 years, comparing developmental trajectories for at-risk youth with a triad of well-replicated antecedents of schizophrenia (ASz) and at-risk youth with a family history of schizophrenia (FHx), each relative to low-risk, typically developing peers (TD). Supplementary analyses explored heterogeneity among ASz youth according to persistence of symptoms, and FHx youth according to familial loading and presence of antecedents. Both ASz and FHx youth demonstrated early deficits (age ∼11 years) in verbal intelligence relative to TD youth, which remained stable into young adulthood. FHx youth additionally showed this stable developmental deficit relative to TD youth in performance intelligence. In exploratory supplementary analyses, verbal intelligence improved with age toward TD performance among ASz children whose psychopathological symptoms remitted during follow-up. Uniquely among FHx youth, those with a low familial loading (one second-degree affected relative only) and none/one of the three antecedents did not evidence the stable developmental deficits in verbal and performance intelligence. These distinct developmental trajectories of verbal and performance intelligence among youth presenting different profiles of schizophrenia risk may signify potential for targeted preventative interventions. Further research is needed to determine whether these trajectories distinguish later transition to schizophrenia from a cognitive vulnerability that normalises among at-risk individuals who do not transition.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"283 ","pages":"Pages 144-151"},"PeriodicalIF":3.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood adverse events and their association with psychotic symptoms and quality of life in young adults with first episode psychosis and unaffected siblings","authors":"Beier Yao ,&nbsp;Mei-Hua Hall ,&nbsp;Emma Tusuzian ,&nbsp;Bruce Cohen ,&nbsp;Dost Öngür ,&nbsp;Virginie-Anne Chouinard","doi":"10.1016/j.schres.2025.07.006","DOIUrl":"10.1016/j.schres.2025.07.006","url":null,"abstract":"<div><div>Childhood adverse events (CAEs) are an important social determinant of health (SDoH) associated with increased risk of adulthood psychosis. In people with psychotic disorders, CAEs have been associated with more severe symptoms and worse functioning. However, less is known about exposure to CAEs and its relationship to functioning in early psychosis and unaffected siblings, who are at a higher genetic and familial risk than the general population. We examined CAE and its relationship with functioning and symptoms in 70 people with early psychosis (EP), 19 unaffected siblings of people with psychosis (SB), and 85 healthy control participants (HC). CAE was measured using the Childhood Trauma Questionnaire. The EP group had more exposure to CAEs than SB and HC, while SB and HC did not differ from each other. Across all groups, exposure to more CAEs predicted worse adult quality of life after controlling for group, sex, and parental education. In people with early psychosis, exposure to more CAEs predicted more severe positive symptoms after controlling for sex, parental education, lifetime substance use, and specific diagnosis. Our findings suggest that CAEs are more common in people with psychosis than unaffected siblings and healthy controls, supporting an association between trauma exposure and psychotic experiences. Moreover, an association between CAEs and later life functioning across all groups speaks to the long-lasting impact of early life SDoH on wellbeing. Early identification and intervention of CAEs is therefore important to consider in the prevention of psychotic disorders, including for individuals at genetic risk of psychosis.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"283 ","pages":"Pages 137-143"},"PeriodicalIF":3.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital phenotyping correlates of cognitive performance in schizophrenia spectrum disorders from a longitudinal study","authors":"Nabagata Das ,&nbsp;Soumya Choudhary ,&nbsp;Srilakshmi Nagendra ,&nbsp;Siddharth Dutt ,&nbsp;Preethi Reddy ,&nbsp;John A Naslund ,&nbsp;John Torous ,&nbsp;Urvakhsh Meherwan Mehta","doi":"10.1016/j.schres.2025.07.009","DOIUrl":"10.1016/j.schres.2025.07.009","url":null,"abstract":"<div><div>Cognitive deficits across social and nonsocial domains are central to functional impairment in schizophrenia. While these deficits are traditionally assessed through neuropsychological testing, recent advancements in smartphone sensor-driven digital phenotyping offer a novel approach for continuous, real-time monitoring of daily behaviors that can be reflective of latent cognitive functioning. We examined the relationship between such digital phenotyping metrics like home-time, screen-duration, and entropy, and social and nonsocial cognitive functioning in 50 participants — 25 diagnosed with schizophrenia spectrum disorders and 25 healthy comparison participants. Passive data were captured using the MindLAMP app over 12 months. At the same time, cognitive assessments were conducted at baseline, 6, and 12 months using the Social Cognition Rating Tool in Indian Setting and Brief Assessment of Cognition in Schizophrenia. We found that greater home-time at baseline and six months was associated with poorer social cognition (faux-pas recognition) at those assessment time points. We also observed that first-month or baseline home-time was associated with subsequent faux-pas recognition at the 6 and 12-month follow-ups. These findings highlight the potential for digital phenotyping markers, such as home-time, to serve as objective behavioral correlates of social cognitive deficits in schizophrenia, offering opportunities for targeted interventions to improve functioning.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"283 ","pages":"Pages 130-136"},"PeriodicalIF":3.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contact with health services for adverse childhood experiences and subsequent risk of non-affective psychotic disorder: Population-based evidence from Ontario, Canada","authors":"Ramez Salama ,&nbsp;Rebecca Rodrigues ,&nbsp;Jinette Comeau ,&nbsp;Yun-Hee Choi ,&nbsp;Martin Rotenberg ,&nbsp;Jordan Edwards ,&nbsp;Britney Le ,&nbsp;Kelly K. Anderson","doi":"10.1016/j.schres.2025.07.010","DOIUrl":"10.1016/j.schres.2025.07.010","url":null,"abstract":"<div><h3>Objective</h3><div>We sought to estimate the association between indicators of health service contact for adverse childhood experiences (ACEs) and the risk of psychotic disorders using population-based health administrative data.</div></div><div><h3>Methods</h3><div>We accessed the Ontario-MINDS cohort, constructed using population-based health administrative data. The cohort included children born between 1992 and 1996, linked to maternal health records, and followed to age 27–31 years to identify incident non-affective psychotic disorder (NAPD) using a validated algorithm. We conducted a scoping review to identify codes indicative of ACE-related health service contacts prior to age 12 years, including indicators of abuse, neglect, and household dysfunction. Multivariable modified Poisson regression models were estimated to obtain incidence rate ratios (IRR) and 95 % confidence intervals (CI).</div></div><div><h3>Results</h3><div>In our analytic sample (<em>n</em> = 559,073), 27.1 % had a health service contact for one or more ACEs. The risk of NAPD was 51 % higher for those with a contact for household dysfunction (IRR = 1.51;95%CI = 1.45,1.58), 78 % higher for those with a contact for abuse/neglect (IRR = 1.78;95%CI = 1.58,2.01), and nearly three-fold higher among those who had health service contacts for both household dysfunction and abuse/neglect (IRR = 2.61;95%CI = 2.38,2.85). We also found a gradient effect, and people with health service contacts for 4+ ACE subtypes had a substantially elevated risk of NAPD (IRR = 4.04; 95%CI = 3.26,5.01), relative to those with no ACE-related contacts.</div></div><div><h3>Conclusions</h3><div>Our findings add population-based evidence to the growing body of literature showing the detrimental effects of ACEs on serious mental disorders, and highlight the utility of administrative databases for advancing research in this field.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"283 ","pages":"Pages 115-121"},"PeriodicalIF":3.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ecological and momentary assessment and intervention for schizophrenia: Use of smartphone apps and video games","authors":"Takeshi Sakurai ,&nbsp;Michel Birnbaum ,&nbsp;Y.H. Victoria Chua ,&nbsp;Tadashi Isa ,&nbsp;Akira Sawa","doi":"10.1016/j.schres.2025.07.007","DOIUrl":"10.1016/j.schres.2025.07.007","url":null,"abstract":"<div><div>Digital technology has been developed to help manage psychiatric disorders, including schizophrenia. Such technology is well suited to monitoring the disease in ecological situations, including the evolution and behavioral outcomes of negative symptoms and cognitive impairments that are often context-dependent, and would also allow timely assessments and interventions. Along the trajectory of schizophrenia disease course, several time windows for the potential applications are present. Approaches, including the monitoring of naturalistic behaviors by smartphone apps for momentary assessment of negative symptoms and cognitive impairments, and cognitive assessment and intervention through various remote platforms such as video games, are reviewed. Hurdles and opportunities including important considerations when applying digital technology to the prevention, evaluation, and intervention of schizophrenia are discussed.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"283 ","pages":"Pages 122-129"},"PeriodicalIF":3.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of individual and environmental socioeconomic status with mental health-related stigma: Evidence from psychiatric hospital staff in China","authors":"Yemin Yuan ,&nbsp;Luping Hei ,&nbsp;Miaomiao Zhao ,&nbsp;Siwei Sun ,&nbsp;Beibei Yuan","doi":"10.1016/j.schres.2025.07.005","DOIUrl":"10.1016/j.schres.2025.07.005","url":null,"abstract":"<div><h3>Background</h3><div>Mental health-related stigma among healthcare providers impedes quality care and patient outcomes. Socioeconomic status (SES) is a critical factor. Existing studies suggest inconsistent associations between individual SES and stigma across populations, and evidence on how individual SES and environmental SES interact to shape stigma remains limited. This study aimed to (1) describe the mental health-related stigma of psychiatric hospital staff in China; (2) explore the association of individual and environmental SES with stigma; (3) examine the interaction between individual SES and environmental SES.</div></div><div><h3>Methods</h3><div>The data were obtained from an online survey of stigma and related factors among psychiatric hospital staff in 6 regions of China. In total, 3323 participants were included in the analysis. SES was divided into individual SES (educational attainment and annual income) and structural SES (regional education levels and regional income levels). Multilevel mixed-effects linear regression was used to examine the association and interaction.</div></div><div><h3>Results</h3><div>We observed that the average score of mental health-related stigma among psychiatric hospital staff in China was 53.3 on a scale of 15–105. In individual SES, a positive association was found between educational attainment and mental health-related stigma (bachelor's degree: adjusted <em>β</em> = 3.252, <em>p</em> &lt; 0.001; master's degree or above: adjusted <em>β</em> = 3.824, <em>p</em> = 0.004). In environmental SES, mental health-related stigma was negatively associated with regional education levels (adjusted <em>β</em> = 3.863, <em>p</em> = 0.012), but positively associated with regional income levels (adjusted <em>β</em> = −3.712, <em>p</em> = 0.018). Regional education levels moderated the positive association between individual SES and mental health-related stigma (adjusted <em>β</em> = −2.226, <em>p</em> = 0.049).</div></div><div><h3>Conclusion</h3><div>Our findings suggest that psychiatric staff with higher SES may be in greatest need of interventions to reduce mental health-related stigma. Enhancing the contact and interaction between psychiatric staff and the public is also essential to mitigate stigma.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"283 ","pages":"Pages 107-114"},"PeriodicalIF":3.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stage-specific computational mechanisms of working memory deficits in first-episode and chronic schizophrenia","authors":"Tongyi Zhang ,&nbsp;Xiaolong Yang ,&nbsp;Pei Mu ,&nbsp;Xiaoning Huo ,&nbsp;Xin Zhao","doi":"10.1016/j.schres.2025.06.012","DOIUrl":"10.1016/j.schres.2025.06.012","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive dysfunction, particularly working memory (WM) impairment, constitutes a core feature of schizophrenia and is largely unresponsive to available antipsychotic treatments. The computational mechanisms underlying WM deficits at different illness stages and their associations with clinical symptom dimensions remain poorly understood.</div></div><div><h3>Methods</h3><div>We applied hierarchical drift diffusion modeling (HDDM) to dissect latent cognitive processes underlying WM performance in a <em>two</em><em>-back</em> task among patients with first-episode schizophrenia (FES, <em>N</em> = 103, illness duration ≤2 years), chronic schizophrenia (ChSz, <em>N</em> = 108, illness duration ≥5 years), and healthy controls (HCs, <em>N</em> = 85). Multiple regression and mediation analyses were conducted to examine associations between HDDM parameters, clinical symptoms, and conventional metrics.</div></div><div><h3>Results</h3><div>Both patient groups exhibited significant WM deficits compared to HCs, with ChSz patients demonstrating more pronounced impairments than FES patients. HDDM analysis revealed that patients showed significantly reduced drift rate and prolonged non-decision time compared to HCs. Notably, while non-decision time remained comparable between FES and ChSz groups, drift rate was significantly lower in ChSz patients, mediated the relationship between illness stage and WM performance, and negatively correlated with negative symptoms and general psychopathology.</div></div><div><h3>Conclusions</h3><div>This study reveals distinct computational profiles of WM deficits across different stages of schizophrenia. While non-decision time impairments emerge early and persist, reduced drift rate progressively deteriorates with illness duration and is closely linked to specific clinical symptoms. These findings enhance our understanding of WM dysfunction across illness stages and support the development of targeted cognitive interventions tailored to illness stage and symptom severity.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"282 ","pages":"Pages 203-213"},"PeriodicalIF":3.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood sexual abuse in first-episode psychosis: The relevance in cognitive bias","authors":"Regina Vila-Badia ,&nbsp;Victoria Espinosa ,&nbsp;Alicia Colomer-Salvans ,&nbsp;Clara Serra-Arumí ,&nbsp;Ariadna Corbella-Sotil ,&nbsp;Núria Del Cacho ,&nbsp;Anna Butjosa ,&nbsp;Susana Ochoa ,&nbsp;Jorge Cuevas-Esteban ,&nbsp;Daniel Muñoz-Samons ,&nbsp;PROFEP Group ,&nbsp;Judith Usall","doi":"10.1016/j.schres.2025.07.004","DOIUrl":"10.1016/j.schres.2025.07.004","url":null,"abstract":"<div><div>Cognitive biases and childhood trauma have been associated with psychotic outcomes; however, the combined effect of these two variables on psychosis has been minimally explored. This study investigates differences in cognitive biases and the presence of sexual abuse between people with first episode of psychosis (FEP) and healthy controls and explores the relationship between childhood sexual abuse and cognitive biases in individuals with FEP, controlling for sociodemographic and clinical confounders. A sample of 85 FEP patients and 87 healthy controls were assessed using the Spanish version of the Cognitive Biases Questionnaire for Psychosis (CBQp) and the Childhood Trauma Questionnaire (CTQ). Participants with FEP exhibited higher levels of cognitive biases (<em>p</em> = .006), including in threatening situations, (<em>p</em> = .022), anomalous perceptions (<em>p</em> = .005), intentionality (<em>p</em> = .007), jumping to conclusions (<em>p</em> = .009), and emotional reasoning (<em>p</em> = .001), compared to healthy controls, while no significant differences were found in catastrophism and dichotomous thinking. FEP participants also reported a higher incidence of childhood sexual abuse (<em>p</em> = .024). Regressions models using enter method indicated that childhood sexual abuse was associated with dichotomous thinking, a pattern of “all-or-nothing” thinking, and emotional reasoning biases, even after adjusting for age, education, psychotic symptoms, and perceived stress. These results highlight the importance of addressing trauma history in early psychosis interventions, emphasizing cognitive-behavioral strategies like Metacognitive Training and Eye Movement Desensitization and Reprocessing.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"283 ","pages":"Pages 98-106"},"PeriodicalIF":3.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of demographic variables in the effectiveness of metacognitive training for psychosis: A meta-analysis","authors":"Hanna Gelner ,&nbsp;Martyna Krężołek ,&nbsp;Adrianna Aleksandrowicz ,&nbsp;Justyna Piwińska ,&nbsp;Maria Lamarca ,&nbsp;Fabrice Berna ,&nbsp;Vanessa Acuña ,&nbsp;Caroline König ,&nbsp;Steffen Moritz ,&nbsp;PERMEPSY Group ,&nbsp;Susana Ochoa ,&nbsp;Łukasz Gawęda","doi":"10.1016/j.schres.2025.06.017","DOIUrl":"10.1016/j.schres.2025.06.017","url":null,"abstract":"<div><h3>Background</h3><div>Meta-cognitive Training (MCT) is a promising therapeutic approach for schizophrenia. However, the extent to which demographic factors influence its efficacy in reducing psychotic symptoms and cognitive biases, as well as enhancing cognitive insight, needs further examination.</div></div><div><h3>Methods</h3><div>A comprehensive search of databases: PubMed, PsycINFO, Scopus, (2007-November 2024) published only in English was conducted. Thirty-seven studies (81 % randomized, 19 % non-randomized trials) were included. Inclusion criteria were participants with a diagnosis of schizophrenia spectrum or related psychotic disorders, and there were no sex, gender, race, or ethnicity restrictions. We analyzed the influence of demographic factors on the efficacy of MCT, and the meta-regression analyses were conducted for variables including sex, age, duration of illness, and years of education.</div></div><div><h3>Results</h3><div>MCT significantly reduced positive symptoms (d = −0.40; <em>p</em> &lt; 0.001), delusions (d = −0.41; p &lt; 0.001), and improved cognitive insight (d = 0.28; <em>p</em> &lt; 0.05). Women benefit more in cognitive insight in self-reflectiveness scale (d = −0.27; <em>p</em> = 0.05). However, no statistically significant gender differences were observed in other domains. Furthermore, no significant results were observed for other sociodemographic variables under study.</div></div><div><h3>Conclusions</h3><div>MCT has been demonstrated to be an effective therapeutic method in the reduction of symptoms associated with schizophrenia, with the impact of demographic factors being limited. The enhancement of cognitive insight, particularly in the domains of self-reflectiveness and self-confidence, has been demonstrated in women. Future research should consider individual differences, particularly in the context of gender to advance personalized therapeutic approaches and optimize psychological interventions.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"283 ","pages":"Pages 85-97"},"PeriodicalIF":3.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“The second I laid eyes on him I knew”: First impressions predict willingness to interact with individuals with schizophrenia","authors":"Tifenn Fauviaux ,&nbsp;Mathilde Parisi ,&nbsp;Ludovic Marin ,&nbsp;Victor Vattier ,&nbsp;Juliette Lozano-Goupil ,&nbsp;Dorra Mrabet ,&nbsp;Delphine Capdevielle ,&nbsp;Stéphane Raffard","doi":"10.1016/j.schres.2025.06.022","DOIUrl":"10.1016/j.schres.2025.06.022","url":null,"abstract":"<div><div>Individuals diagnosed with schizophrenia often experience social interaction deficits, and these difficulties may arise as early as the first encounter. First impressions, formed during initial interactions, are crucial in shaping relationship outcomes. This study explored how first impressions formed during initial encounters influence the quality of social interactions between healthy individuals and those with schizophrenia. We recruited 60 participants, including 20 healthy individuals to serve as interacting partners, 20 individuals diagnosed with schizophrenia, and 20 age and sex-matched healthy controls. Each interacting partner interacted once with an individual diagnosed with schizophrenia and once with a sex- and age-matched healthy control, without knowledge of any diagnosis. Upon arrival at the experiment location, participants were briefly introduced to each other and then asked to rate their first impressions independently. Then, they engaged in four conversational tasks, after which they assessed their willingness to continue interacting—a measure of social interaction quality. Results showed that interacting partners rated individuals with schizophrenia more negatively than healthy controls in both first impressions and willingness to continue interacting. While first impression ratings across all participants significantly predicted willingness to continue interacting, they did not mediate the group differences in willingness scores, suggesting the involvement of additional underlying factors. This study is the first to assess first impressions of individuals with schizophrenia in ecological settings, marking an important step toward understanding the factors contributing to altered first impressions of individuals diagnosed with schizophrenia.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"283 ","pages":"Pages 77-84"},"PeriodicalIF":3.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}