Schizophrenia Research最新文献

{"title":"Sub-clinical systemic inflammation as a determinant of admission duration in psychosis","authors":"Graham Blackman ,&nbsp;James DeLaney ,&nbsp;James H. MacCabe ,&nbsp;Golam Khandaker ,&nbsp;Philip McGuire","doi":"10.1016/j.schres.2024.12.010","DOIUrl":"10.1016/j.schres.2024.12.010","url":null,"abstract":"<div><h3>Background</h3><div>The immune system may play an important role in the aetiology of psychotic disorders and there is increasing interest in the relationship between immune markers and clinical outcomes in psychosis. The present study investigated whether subclinical systemic inflammation was associated with length of stay in individuals with psychosis admitted to a psychiatric hospital. We tested the hypothesis that a higher level of subclinical systemic inflammation, as measured by the neutrophil-to-lymphocyte ratio (NLR) would be associated with a longer period in hospital.</div></div><div><h3>Method</h3><div>Retrospective cohort study based on electronic health records. We included patients with a psychosis spectrum disorder (ICD10: F20-F29) who had a routine blood test upon being admitted to a psychiatric hospital within the South London and Maudsley NHS Foundation Mental Health Trust, London, UK between 2013 and 2019. Multiple linear regression was used to determine the association between the NLR at the time of admission and the duration of the corresponding hospital stay, adjusting for covariables.</div></div><div><h3>Results</h3><div>Data from 1683 individuals with psychosis were analyzed. The median admission duration was 31 days (interquartile range = 48 days). Higher neutrophil-to-lymphocyte ratio (NLR) was significantly associated with longer admission (<span><math><mi>B</mi></math></span> = 0.07, <em>p</em> <em>&lt;</em> 0.003) after adjusting for covariates.</div></div><div><h3>Conclusion</h3><div>An association between a NLR and a longer admission, whilst controlling for relevant covariables, was observed highlighting the potential utility of inflammatory markers as prognostic marker in clinical settings.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 17-23"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional intelligence as a predictor of functional outcomes in psychotic disorders","authors":"Jennifer M. Blank ,&nbsp;Roman Kotov ,&nbsp;Katherine G. Jonas ,&nbsp;Wenxuan Lian ,&nbsp;Elizabeth A. Martin","doi":"10.1016/j.schres.2025.01.005","DOIUrl":"10.1016/j.schres.2025.01.005","url":null,"abstract":"<div><div>Psychotic disorders are associated with significant impairment in psychosocial functioning, yet mechanisms associated with this impairment remain poorly understood. Emotional intelligence, a component of social cognition, is associated with psychosocial functioning in this population. However, prior work has used relatively small samples, reported inconsistent relations between functioning domains and emotional intelligence, and inconsistently considered negative symptoms. To address these limitations, we examined the predictive ability of emotional intelligence on functional outcomes using a five-year longitudinal design. We used a large sample of individuals with and without psychotic disorder diagnoses (N = 324), a performance-based measure of emotional intelligence, and three measures of functioning (i.e., social performance, assessor-rated social and occupational functioning, self-rated functioning in independent living). Results revealed individuals diagnosed with a psychotic disorder have lower emotional intelligence than those without a history of psychosis. Emotional intelligence was associated with social performance and social and occupational functioning in both those with and without a history of psychosis. In those diagnosed with a psychotic disorder, emotional intelligence and negative symptoms better predict social performance (<span><math><mi>β</mi></math></span>_Emotional = 0.36, R²_delta = 0.09) and social and occupational functioning (<span><math><mi>β</mi></math></span>_Emotional = 0.21, R² = 0.03), but not self-rated functioning in independent living (<span><math><mi>β</mi></math></span>_Emotional = −0.08, R²_delta = 0.00), as compared to negative symptoms alone. Overall, findings support the use of emotional intelligence as a longitudinal predictor of social and occupational outcomes above and beyond negative symptoms alone. This work highlights potential, specific intervention targets for individuals with psychotic disorders.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 97-105"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic interactions among schizotypal traits, affective and prodromal symptoms, social functioning in a large sample of college students: A cross-lagged panel network analysis","authors":"Shou-nuo Chen ,&nbsp;Guo-hui Zhu ,&nbsp;Juan Yang ,&nbsp;Wen-ting Hu ,&nbsp;Xue Meng ,&nbsp;Li-ying Zhang ,&nbsp;Yi Wang ,&nbsp;Yan-yu Wang","doi":"10.1016/j.schres.2025.01.016","DOIUrl":"10.1016/j.schres.2025.01.016","url":null,"abstract":"<div><h3>Objective</h3><div>Previous studies suggested that schizotypal traits are closely related with affective symptoms and social dysfunction in general population. However, the dynamic interactions among these variables across time remain unclear. This study aimed to investigate this issue using cross-sectional and longitudinal network analysis.</div></div><div><h3>Methods</h3><div>A total of 9136 college students completed self-report scales measuring schizotypal traits, anxiety, depression, prodromal risk, and social functioning at timepoint 1 (T1) and six months later. Classical contemporaneous network analysis was used to estimate the associations among all variables at T1, and the cross-lagged panel network analysis was performed to estimate the predictive effects at follow-up. In addition, prodromal high-risk and low-risk subgroups at T1 were identified using Prodromal Questionnaire (PQ-16) to investigate differences on network constructs and edge weights using Network Comparison Tests (NCT).</div></div><div><h3>Results</h3><div>Contemporaneous network showed that negative dimension of schizotypal traits, anxiety, and depression interacted and were all negatively correlated with social functioning. Of all the nodes in the network, interpersonal features of schizotypal traits was the most centralized. The results of cross-lagged network analysis further verified the predictive effect of personality traits and emotions on social function. In addition, NCT revealed significant difference between prodromal high-risk and low-risk subgroups in network structure and strength of edges connecting schizotypal traits, affective symptoms with prodromal risk, but not in global strength.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that schizotypal traits, affective symptoms, and prodromal risk relate to social functioning, both independently and through their dynamic interactions.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 108-116"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA-regulated suppression of some overexpressed genes in schizophrenia and their evolutionary significance","authors":"Deepika Sharma ,&nbsp;Srinjay Kumar Bharadaj ,&nbsp;Stella Bharadaj ,&nbsp;Supriyo Chakraborty","doi":"10.1016/j.schres.2025.01.022","DOIUrl":"10.1016/j.schres.2025.01.022","url":null,"abstract":"<div><div>Impaired formation of the brain or nervous system is the root cause of neurodevelopmental disorders which appear in pregnancy or soon after birth. One such neurodevelopmental disorder is Schizophrenia. Among the most serious forms of psychosis, Schizophrenia (SCZ) affects 1 % of the general population. MiRNA targeting sites and codon usage of nine overexpressed genes in Schizophrenia were investigated in this study. The neutrality plot demonstrated the importance of natural selection over mutational pressure in the evolution of these genes. The analysis of COSM revealed that the miRNA target regions of the genes were encoded by non-optimal codons, resulting in low translational efficiency, whereas the GC content revealed that the miRNA-mRNA binding was strong. From this study it was concluded that each overexpressed gene was targeted by several human miRNAs for putative suppression. These identified miRNAs could have therapeutic potential in Schizophrenia therapy.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 143-156"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the behavioural inhibition and activation system in the association between attachment style and positive or negative symptoms in patients with psychosis and unaffected siblings","authors":"Justine de With ,&nbsp;Marieke van der Pluijm ,&nbsp;Lieuwe de Haan ,&nbsp;Frederike Schirmbeck ,&nbsp;Genetic Risk and Outcome of Psychosis (GROUP) investigators","doi":"10.1016/j.schres.2025.01.020","DOIUrl":"10.1016/j.schres.2025.01.020","url":null,"abstract":"<div><h3>Background</h3><div>The association between attachment style and psychotic symptomatology is well established. However, little is known about the mechanisms underlying this relationship. In the present study, we aimed to investigate whether the sensitivity of the behavioural inhibition and activation system mediates the association between attachment style and positive or negative symptoms, in patients with psychotic disorders and unaffected siblings.</div></div><div><h3>Methods</h3><div>In a subsample of the Genetic Risk and Outcome of Psychosis (GROUP) study (87 patients and 94 siblings), attachment style was assessed using the Psychotic Attachment Measure, behavioural inhibition or activation with the Behavioral Inhibition System (BIS) and Behavioral Activation System (BAS) Scale and positive and negative symptomatology with the Community Assessment of Psychic Experiences. Linear regression models and mediation models were used, while correcting for age and gender and adjusting for multiple testing.</div></div><div><h3>Results</h3><div>We found that anxious and avoidant attachment were associated with negative symptoms across both groups. Additionally, in siblings, anxious and avoidant attachment were associated with positive symptoms. In the patient group, BIS sensitivity mediated the association between anxious attachment and negative symptoms. In the sibling group, BIS sensitivity mediated the association between avoidant attachment and both positive and negative symptoms, and between anxious attachment and positive symptoms.</div></div><div><h3>Conclusions</h3><div>Findings indicate that BIS sensitivity, but not BAS sensitivity, is a possible mediating mechanism contributing to the association between insecure attachment and psychotic symptoms. Longitudinal studies are required to confirm the associations between attachment style, BIS and BAS sensitivity, and psychotic symptoms, and explore causality.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 127-134"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obsessive-compulsive symptoms and personal recovery in patients with schizophrenia spectrum disorders: A cross-sectional study","authors":"A. Jelsma ,&nbsp;F. Schirmbeck ,&nbsp;M. van der Pluijm ,&nbsp;C. Simons ,&nbsp;A. Vellinga ,&nbsp;M. de Koning ,&nbsp;L. de Haan","doi":"10.1016/j.schres.2025.01.008","DOIUrl":"10.1016/j.schres.2025.01.008","url":null,"abstract":"<div><h3>Background</h3><div>Obsessive-compulsive symptoms (OCS) frequently co-occur in patients with Schizophrenia Spectrum Disorders (SSD). Patients with SSD and OCS experience increased clinical and social challenges, including diminished quality of life and subjective well-being. However, it is unknown whether co-morbid OCS are associated with personal recovery.</div></div><div><h3>Aim</h3><div>To investigate whether the presence and severity of OCS in patients with SSD is associated with lower self-reported personal recovery.</div></div><div><h3>Methods</h3><div>A cross-sectional design was employed, examining 527 patients with SSD. Group comparisons between patients with and without OCS for self-reported personal recovery (assessed with the Recovery Assessment Scale (RAS-24)) were conducted using analysis of covariance, adjusting for positive, negative and general symptoms. Multiple regression analyses were performed in 133 patients with co-occurring OCS to assess the additional explained variance in personal recovery by OCS severity after adjusting for the same covariates in the first block of the model.</div></div><div><h3>Results</h3><div>Group comparisons demonstrated that the presence of co-morbid OCS was associated with lower scores in personal recovery. Multiple hierarchical regression analyses showed that OCS severity was significantly associated with personal recovery by explaining an additional 3.0 % of variance in personal recovery.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that co-occurring OCS in patients with SSD are relevant for personal recovery and that treatment should also address OCS.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 24-30"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capturing changes in social functioning and positive affect using ecological momentary assessment during a 12-month trial of xanomeline and trospium chloride in schizophrenia","authors":"Philip D. Harvey ,&nbsp;Inder Kaul ,&nbsp;Soumya Chataverdi ,&nbsp;Tej Patel ,&nbsp;Amy Claxton ,&nbsp;Colin Sauder ,&nbsp;John N. Saber ,&nbsp;Stephen K. Brannan ,&nbsp;William P. Horan","doi":"10.1016/j.schres.2025.01.019","DOIUrl":"10.1016/j.schres.2025.01.019","url":null,"abstract":"<div><h3>Background</h3><div>Experiential negative symptoms (NS) are determinants of disability in schizophrenia (SCZ). Xanomeline/Trospium Chloride (X/T), an M1/M4 muscarinic receptor agonist, is an approved monotherapy for treatment of schizophrenia, including NS. We used remote ecological momentary assessments (EMA) to track changes in indicators of NS during 12 months of outpatient treatment with X/T.</div></div><div><h3>Methods</h3><div>After discontinuing previous medications, 566 outpatients with SCZ received open-label X/T monotherapy for up to 12 months. Participants completed 3 EMA surveys 7 days a week, one week a month. Surveys queried whether participants were home vs. away and alone vs with someone, as well as productive and unproductive activities, and moods. Hierarchical linear modeling (HLM) examined temporal changes and the relationships between the indicators of NS.</div></div><div><h3>Results</h3><div>500 participants answered one or more EMA surveys and 350 met 33 % adherence criteria, answering a total of 40,464 surveys, with overall adherence among these participants at 66 %. During treatment with X/T, there were significant decreases in surveys at home (p &lt; .001), alone (p &lt; .001), and engaging in unproductive activities (p &lt; .001). There were significant increases in productive activities both home (p &lt; .001) and away (p &lt; .001) and in positive affect (PA) (p &lt; .001). Improvements in PA converged with reduced unproductive activities, particularly when others were present (p &lt; .001).</div></div><div><h3>Conclusions</h3><div>Behavioral indicators of NS improved early and were sustained with X/T treatment. Improvements were multidimensional, shifting toward more time with others, away from home, and engaged in productive activities. These improvements were associated with increases in PA, consistent with previous EMA studies of NS.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 117-126"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter to the Editor “Reflections on a study of electroconvulsive therapy for clozapine-refractory schizophrenia” (Jolly et al. Schizophrenia Research, 267 (2024) 32-33)","authors":"Helio Elkis ,&nbsp;Christoph U. Correll ,&nbsp;Debora L. Melzer-Ribeiro","doi":"10.1016/j.schres.2025.01.003","DOIUrl":"10.1016/j.schres.2025.01.003","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 15-16"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive mental health interventions for people with schizophrenia: A scoping review","authors":"Catarina Nogueira ,&nbsp;Emanuel Dias Pereira ,&nbsp;Joana Catarina Ferreira Coelho ,&nbsp;Antonio Rafael Moreno-Poyato ,&nbsp;Carlos Alberto Cruz Sequeira","doi":"10.1016/j.schres.2025.01.009","DOIUrl":"10.1016/j.schres.2025.01.009","url":null,"abstract":"<div><h3>Background</h3><div>Promoting positive mental health is crucial for maintaining a healthy balance of mental well-being, both for individuals with and without mental health conditions, including schizophrenia.</div></div><div><h3>Objective</h3><div>To map interventions that promote positive mental health in individuals with schizophrenia.</div></div><div><h3>Methods</h3><div>We conducted a scoping review following Joanna Briggs Institute recommendations. Searches were performed on Scopus, MEDLINE and CINAHL Complete (via EBSCOhost), and RCAAP for grey literature. Papers that met the following criteria were included: published from September 1999 to May 2023; involving only individuals diagnosed with schizophrenia; focused on interventions that promote positive mental health; presenting interventions with defined objectives and duration; designed for individuals or groups.</div></div><div><h3>Results</h3><div>We identified 1111 potentially relevant records, which were screened by 2 independent researchers. 26 studies, published between 2004 and 2023 were found eligible. Most of the identified interventions were implemented in community-based settings (<em>n</em> = 22), in group formats (<em>n</em> = 20), with a total duration between 4 and 12 weeks (<em>n</em> = 20), session duration about 45–60 min (<em>n</em> = 13) and without <em>follow up</em> (<em>n</em> = 17). A significant number of interventions focused on improving interpersonal relationship capacity (<em>n</em> = 15) and personal satisfaction (<em>n</em> = 13). 9 interventions focused on enhancing autonomy, 3 on promoting self-control, 2 on problem-solving/self-actualization and 1 on promoting pro-social attitude.</div></div><div><h3>Conclusions</h3><div>This scoping review can contribute to improving the quality of care provided and optimizing health outcomes, enhancing the promotion of community health through increased knowledge in the field of positive mental health.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 40-56"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143041297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of family-based interventions for early psychosis: Carer and patient outcomes","authors":"John F.M. Gleeson ,&nbsp;Kelsey Ludwig ,&nbsp;Bryan J. Stiles ,&nbsp;Stefan Piantella ,&nbsp;Catharine McNab ,&nbsp;Sue Cotton ,&nbsp;Madeleine I. Fraser ,&nbsp;Mario Alvarez-Jimenez ,&nbsp;Amity Watson ,&nbsp;Elizabeth Fraser ,&nbsp;David L. Penn","doi":"10.1016/j.schres.2025.01.006","DOIUrl":"10.1016/j.schres.2025.01.006","url":null,"abstract":"<div><h3>Background</h3><div>Previous reviews have indicated that family interventions in early psychosis are beneficial for patients and family caregivers. Given recent developments in research and service provision an updated review is warranted.</div></div><div><h3>Methods</h3><div>We conducted a systematic review and meta-analysis of family intervention trials in the first 5 years after psychosis onset. We identified randomized controlled trials that reported outcomes for family members and extracted available outcomes in relation to identified patients.</div></div><div><h3>Results</h3><div>We screened 8737 abstracts and 177 full text papers, resulting in 36 for extraction. We found significant pooled treatment effects for family interventions for carer psychological distress (Hedges <em>g</em> = 0.35), carer burden (Hedges <em>g</em> = −0.68), positive and negative carer appraisals (Hedges <em>g</em> = 0.20, <em>g</em> = −0.21), and components of expressed emotion (critical comments and emotional overinvolement) compared with care as usual (Hedges <em>g</em> = −0.81, −0.92). For patients we found a moderate pooled effect for reduced rates of hospitalization compared with care as usual (Hedges <em>g</em> = −0.52). The effects for carer burden were maintained for studies in China, but not in other settings combined. The effects for hospitalization were maintained for multicomponent interventions but not when psychoeducation was the sole component. There was evidence of significant study heterogeneity. Risk of bias assessment indicated that deviations from intended treatment were most frequently rated as the weakest domain.</div></div><div><h3>Conclusions</h3><div>Family interventions for early psychosis benefit both family carers and their relatives diagnosed with psychosis when compared with usual care. Future research should further clarify the effective components and investigate innovations in cultural sensitivity, peer support and digital modes.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 57-78"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143041300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}