Schizophrenia Research最新文献

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Pathways linking adverse childhood experiences to psychosis risk in Lagos, Nigeria: A structural equation modeling approach 在尼日利亚拉各斯,连接不良童年经历与精神病风险的途径:结构方程建模方法
IF 3.5 2区 医学
Schizophrenia Research Pub Date : 2025-10-10 DOI: 10.1016/j.schres.2025.09.030
Abiodun O. Adewuya , Olabisi E. Oladipo , Robin Emsley , Laila Asmal
{"title":"Pathways linking adverse childhood experiences to psychosis risk in Lagos, Nigeria: A structural equation modeling approach","authors":"Abiodun O. Adewuya ,&nbsp;Olabisi E. Oladipo ,&nbsp;Robin Emsley ,&nbsp;Laila Asmal","doi":"10.1016/j.schres.2025.09.030","DOIUrl":"10.1016/j.schres.2025.09.030","url":null,"abstract":"<div><h3>Background</h3><div>Adverse childhood experiences (ACEs) are established risk factors for psychosis, yet evidence from low- and middle-income countries (LMICs) remains limited. This study investigated associations between ACEs, psychotic-like experiences (PLEs), and psychosis diagnosis in Nigeria, examining psychological and cognitive mediating pathways.</div></div><div><h3>Methods</h3><div>Data from the Lagos State Mental Health Survey included 1953 adults: 945 cases with persistent PLEs (including 95 with psychosis) and 1008 matched controls. Generalized structural equation modeling with probit links examined: (1) direct ACE-psychosis associations; (2) mediation via common mental disorders (CMDs), resilience, self-esteem, and cognitive functioning; (3) moderation by family history and obstetric complications; and (4) contributions of cannabis use, parental bonding, and adult trauma. Population validation utilized the full representative sample (N = 11,246) with inverse probability weights.</div></div><div><h3>Results</h3><div>The model demonstrated acceptable fit (CFI = 0.94, RMSEA = 0.057). ACEs showed significant associations with PLEs (β = 0.225, <em>p</em> = 0.038) and psychosis (β = 0.105, <em>p</em> = 0.002). CMDs and resilience significantly mediated these relationships, accounting for 21 % and 23 % of total effects respectively. Cognitive functioning mediated 18 % of associations, while self-esteem showed non-significant mediation. Family history and obstetric complications significantly moderated ACE-psychosis pathways. Cannabis use and adult trauma were non-significant; parental bonding showed weak associations.</div></div><div><h3>Conclusion</h3><div>ACEs are significantly linked to psychosis in Nigeria through psychological and cognitive pathways, with effects amplified by familial and perinatal vulnerabilities. Prevention strategies in LMICs should integrate trauma-informed interventions, resilience enhancement, and community-based support systems targeting identified mediating mechanisms.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 276-285"},"PeriodicalIF":3.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of understanding social media use in clinical high risk youth: Implications for research and clinical practice 了解社交媒体在临床高风险青年中的重要性:对研究和临床实践的影响
IF 3.5 2区 医学
Schizophrenia Research Pub Date : 2025-10-10 DOI: 10.1016/j.schres.2025.10.004
Katerina Konstas , Leslie Horton , Tina Gupta
{"title":"The importance of understanding social media use in clinical high risk youth: Implications for research and clinical practice","authors":"Katerina Konstas ,&nbsp;Leslie Horton ,&nbsp;Tina Gupta","doi":"10.1016/j.schres.2025.10.004","DOIUrl":"10.1016/j.schres.2025.10.004","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 286-287"},"PeriodicalIF":3.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polygenic risk score of glycemic homeostasis, Type 2 Diabetes Mellitus and glycemic components in first episode psychosis 首发精神病患者血糖稳态、2型糖尿病和血糖成分的多基因风险评分
IF 3.5 2区 医学
Schizophrenia Research Pub Date : 2025-10-10 DOI: 10.1016/j.schres.2025.09.019
Alex G. Segura , Norma Verdolini , Isabel Valli , Clemente Garcia-Rizo , Covadonga M. Diaz-Caneja , Eduard Vieta , Gisela Mezquida , Antonio Lobo , Ana Gonzalez-Pinto , Álvaro Andreu-Bernabeu , Alejandra Roldan , Anabel Martinez-Aran , Inmaculada Baeza , Anna Mane , Javier Labad , Daniel J. Müller , Nora Guasch-Capella , Miquel Bernardo , Sergi Mas , PEPs Group, Manuel J. Cuesta
{"title":"Polygenic risk score of glycemic homeostasis, Type 2 Diabetes Mellitus and glycemic components in first episode psychosis","authors":"Alex G. Segura ,&nbsp;Norma Verdolini ,&nbsp;Isabel Valli ,&nbsp;Clemente Garcia-Rizo ,&nbsp;Covadonga M. Diaz-Caneja ,&nbsp;Eduard Vieta ,&nbsp;Gisela Mezquida ,&nbsp;Antonio Lobo ,&nbsp;Ana Gonzalez-Pinto ,&nbsp;Álvaro Andreu-Bernabeu ,&nbsp;Alejandra Roldan ,&nbsp;Anabel Martinez-Aran ,&nbsp;Inmaculada Baeza ,&nbsp;Anna Mane ,&nbsp;Javier Labad ,&nbsp;Daniel J. Müller ,&nbsp;Nora Guasch-Capella ,&nbsp;Miquel Bernardo ,&nbsp;Sergi Mas ,&nbsp;PEPs Group,&nbsp;Manuel J. Cuesta","doi":"10.1016/j.schres.2025.09.019","DOIUrl":"10.1016/j.schres.2025.09.019","url":null,"abstract":"<div><h3>Objective</h3><div>First episode of psychosis (FEP) is associated with glucose homeostasis abnormalities even before pharmacological intervention. Given inconclusive GWAS results regarding a direct genetic link between schizophrenia and type 2 diabetes mellitus (T2DM), we hypothesized that FEP patients may exhibit altered genetic risk for glycemic traits. We compared polygenic risk scores (PRS) for T2DM (PRS<sub>T2DM</sub>), fasting glucose (PRS<sub>FG</sub>), and glycated hemoglobin (HbA1c) (PRS<sub>HbA1c</sub>) between FEP patients and controls, examining their associations with glycemic measures over 24 months.</div></div><div><h3>Methods</h3><div>We analyzed data from 242 FEP patients and 119 controls, assessing fasting serum glucose and HbA1c at baseline and 24 months. We examined cross-sectional and longitudinal associations between PRS and glycemic measures within each group.</div></div><div><h3>Results</h3><div>FEP patients and controls did not differ significantly in PRS. Significant associations were observed for PRS<sub>FG</sub> with baseline serum glucose in controls (<em>p</em> = 0.008), PRS<sub>FG</sub> during follow-up (<em>p</em> = 0.034), PRS<sub>HbA1c</sub> at 24 months (<em>p</em> = 0.018), and HbA1c longitudinally (<em>p</em> = 0.025). After multiple testing corrections, only the association between PRS<sub>FG</sub> and baseline serum glucose in controls remained significant (p_adj = 0.023). No associations were found for PRS<sub>T2DM.</sub></div></div><div><h3>Conclusions</h3><div>Despite the link between FEP and glycemic disturbances, PRS<sub>T2DM</sub> did not differ between FEP patients and controls. However, PRS for glycemic traits showed associations with glycemic measures in both groups before multiple testing correction, suggesting that genetic predisposition may influence glucose homeostasis in early psychosis. The absence of a direct association between common genetic variants underlying T2DM and early glycemic dysregulation in FEP underscores the importance of considering environmental factors and epigenetic mechanisms.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 265-275"},"PeriodicalIF":3.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emotional maltreatment shapes the relationship between psychosocial functioning and hippocampal structure in schizophrenia spectrum disorders 精神分裂症谱系障碍的情感虐待塑造了社会心理功能和海马结构之间的关系。
IF 3.5 2区 医学
Schizophrenia Research Pub Date : 2025-10-08 DOI: 10.1016/j.schres.2025.09.031
Dilsa Cemre Akkoc Altinok , Stefan Fritze , Sebastian Volkmer , Geva A. Brandt , Lana Wölfl , Jacqueline Kukovic , Oksana Berhe , Yuchen Lin , Heike Tost , Urs Braun , Andreas Meyer-Lindenberg , Dusan Hirjak
{"title":"Emotional maltreatment shapes the relationship between psychosocial functioning and hippocampal structure in schizophrenia spectrum disorders","authors":"Dilsa Cemre Akkoc Altinok ,&nbsp;Stefan Fritze ,&nbsp;Sebastian Volkmer ,&nbsp;Geva A. Brandt ,&nbsp;Lana Wölfl ,&nbsp;Jacqueline Kukovic ,&nbsp;Oksana Berhe ,&nbsp;Yuchen Lin ,&nbsp;Heike Tost ,&nbsp;Urs Braun ,&nbsp;Andreas Meyer-Lindenberg ,&nbsp;Dusan Hirjak","doi":"10.1016/j.schres.2025.09.031","DOIUrl":"10.1016/j.schres.2025.09.031","url":null,"abstract":"<div><h3>Background</h3><div>The hippocampus and amygdala are important limbic structures involved in memory, emotional regulation, and stress response, which are pivotal for social interactions, everyday functioning, and participation in community life. However, the presumably bidirectional relationship between limbic structure and psychosocial functioning—and the potential moderating role of early-life environmental risk factors—remains poorly understood in schizophrenia spectrum (SSD) and mood disorders (MOD).</div></div><div><h3>Methods</h3><div>Structural 3 T MRI data were collected from SSD (<em>n</em> = 64) and MOD (<em>n</em> = 66) patients as well as healthy controls (HC, <em>n</em> = 46). Hippocampal subfields and amygdala nuclei were segmented using FreeSurfer v7.3.2. Psychosocial functioning was assessed with the Personal and Social Performance Scale (PSP). Childhood maltreatment, urban upbringing, and migration background were examined as potential moderators.</div></div><div><h3>Results</h3><div>SSD patients showed significant volume reductions in left hippocampal subfields compared to HC (FDR-corrected <em>p</em> &lt; .05). Within SSD, PSP scores were associated with volumes of the left hippocampal body, tail, and molecular layer (FDR-corrected <em>p</em> &lt; .05), with emotional abuse and neglect significantly moderating these associations. No other environmental risk factors showed significant interaction effects. In MOD, only the left fimbria differed from HC (FDR-corrected <em>p</em> &lt; .05), but this was unrelated to PSP scores, and no significant interactions were found.</div></div><div><h3>Conclusion</h3><div>Our findings indicate that early-life emotional adversity moderates the relationship between psychosocial functioning and hippocampal structure in SSD, but not in MOD, highlighting the need to consider emotional trauma histories when investigating functional outcomes in SSD patients.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 242-254"},"PeriodicalIF":3.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcortical brain abnormalities and cognitive function in individuals with psychosis and their unaffected relatives: A normative modeling approach 精神病患者及其未受影响亲属的皮质下脑异常和认知功能:一种规范的建模方法。
IF 3.5 2区 医学
Schizophrenia Research Pub Date : 2025-10-08 DOI: 10.1016/j.schres.2025.09.025
Andreea Maria Stǎnicǎ , Natalie Remiszewski , Chen Shen , Scott R. Sponheim , Gerhard S. Hellemann , Nina V. Kraguljac , Junghee Lee
{"title":"Subcortical brain abnormalities and cognitive function in individuals with psychosis and their unaffected relatives: A normative modeling approach","authors":"Andreea Maria Stǎnicǎ ,&nbsp;Natalie Remiszewski ,&nbsp;Chen Shen ,&nbsp;Scott R. Sponheim ,&nbsp;Gerhard S. Hellemann ,&nbsp;Nina V. Kraguljac ,&nbsp;Junghee Lee","doi":"10.1016/j.schres.2025.09.025","DOIUrl":"10.1016/j.schres.2025.09.025","url":null,"abstract":"<div><div>Previous research has shown subcortical aberrations in individuals with psychosis (probands) and their unaffected first-degree relatives. However, few studies directly evaluated whether the pattern of aberration is similar across multiple subcortical regions and across probands and relatives, and whether the relationship between subcortical aberrations and cognition is similar between probands and unaffected relatives. To address these questions, this study employed a normative modeling approach and examined deviation scores of five subcortical regions from the normative range of 127 probands, 86 unaffected relatives, and 50 controls from the Psychosis Human Connectome Project. Cognitive performance was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS). The pattern of deviations across subcortical regions differed between probands and relatives, such that compared to relatives, probands had more negative deviations in the hippocampus, thalamus and amygdala but not in other subcortical regions. Further, compared to the reference norm, both probands and relatives showed negative hippocampal deviations, but only probands had negative thalamic, amygdala, and nucleus accumbens deviations. In both hippocampus and thalamus, negative deviations were related to poor cognitive performance across both groups. These findings suggest that the pattern of structural aberration is not uniform across subcortical regions across probands and relatives. Negative hippocampal deviations appear to reflect genetic risk to psychosis, whereas negative thalamic, amygdala, and nucleus accumbens deviations may be psychosis specific. Subcortical structural aberrations may contribute to poor cognition in both probands and unaffected relatives.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 255-264"},"PeriodicalIF":3.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Duration of active psychosis: A scoping review of definition, measurement, and relationship with outcomes 活动性精神病的持续时间:定义、测量和与结果的关系的范围综述。
IF 3.5 2区 医学
Schizophrenia Research Pub Date : 2025-10-07 DOI: 10.1016/j.schres.2025.09.032
Paul Crowley , Jack Healy , Nick McNamara , Ralph Twomey , Ewa Sadowska , Joseph Firth , Kelly Allott , Jai Shah , Brian O'Donoghue , John Lyne
{"title":"Duration of active psychosis: A scoping review of definition, measurement, and relationship with outcomes","authors":"Paul Crowley ,&nbsp;Jack Healy ,&nbsp;Nick McNamara ,&nbsp;Ralph Twomey ,&nbsp;Ewa Sadowska ,&nbsp;Joseph Firth ,&nbsp;Kelly Allott ,&nbsp;Jai Shah ,&nbsp;Brian O'Donoghue ,&nbsp;John Lyne","doi":"10.1016/j.schres.2025.09.032","DOIUrl":"10.1016/j.schres.2025.09.032","url":null,"abstract":"<div><h3>Background</h3><div>A longer duration of untreated psychosis (DUP) is associated with poorer outcomes across a range of domains, yet this period only represents a proportion of the time individuals experience psychotic symptoms. The duration of active psychosis (DAP) concept addresses this by estimating the duration of psychosis both before and after treatment initiation. This scoping review aims to describe the literature related to this concept, with a particular focus on definition, measurement, and relationship with outcomes.</div></div><div><h3>Methods</h3><div>A systematic search of four databases (MEDLINE, Embase, PsycINFO, CINAHL) and the grey literature was conducted. Studies that examined DAP in individuals with first-episode psychosis were eligible for inclusion. Each article was screened independently by two reviewers. Data were extracted using a deductive approach and results were analysed using qualitative content analysis.</div></div><div><h3>Results</h3><div>The search yielded 3081 unique articles. 37 articles underwent full-text review and nine were eligible for inclusion. DAP is defined as the cumulative duration of two variables, the DUP and the duration of psychosis after treatment initiation (DAT). DAT measurement was mostly conducted prospectively, using a predetermined symptom severity threshold to define active psychosis. The limited studies to date report an association between longer DAP and worse cognitive and negative symptom outcomes, while longer DAT was associated with worse functional outcomes.</div></div><div><h3>Conclusions</h3><div>Further research is required to determine the relationship between DAP and clinical outcomes. Establishing consensus on how to define and measure DAP is critical to enhance early identification of treatment resistance and ensure timely intervention with appropriate treatments.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 232-241"},"PeriodicalIF":3.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between the exposome score for schizophrenia and functioning in remitted first-episode psychosis: results from the HAMLETT study 精神分裂症暴露评分与缓解首发精神病功能之间的关系:来自HAMLETT研究的结果。
IF 3.5 2区 医学
Schizophrenia Research Pub Date : 2025-10-06 DOI: 10.1016/j.schres.2025.09.023
Sterre Kamphuis , Angelo Arias-Magnasco , Shiral Gangadin , Marieke Begemann , Ben Wijnen , Wim Veling , Lieuwe de Haan , HAMLETT-OPHELIA Consortium, Iris Sommer , Jim van Os , P. Roberto Bakker , Sinan Gülöksüz
{"title":"Association between the exposome score for schizophrenia and functioning in remitted first-episode psychosis: results from the HAMLETT study","authors":"Sterre Kamphuis ,&nbsp;Angelo Arias-Magnasco ,&nbsp;Shiral Gangadin ,&nbsp;Marieke Begemann ,&nbsp;Ben Wijnen ,&nbsp;Wim Veling ,&nbsp;Lieuwe de Haan ,&nbsp;HAMLETT-OPHELIA Consortium,&nbsp;Iris Sommer ,&nbsp;Jim van Os ,&nbsp;P. Roberto Bakker ,&nbsp;Sinan Gülöksüz","doi":"10.1016/j.schres.2025.09.023","DOIUrl":"10.1016/j.schres.2025.09.023","url":null,"abstract":"<div><h3>Background</h3><div>Environmental risk factors contribute to functional impairment, which can persist even after symptomatic remission of a first episode of psychosis (FEP). To quantify this effect, we calculated the association between exposome score for schizophrenia (ES-SCZ), a cumulative environmental liability score, and functioning in remitted FEP patients.</div></div><div><h3>Methods</h3><div>Data of 286 participants were derived from the HAMLETT study. General functioning was assessed using the Global Assessment of Functioning (GAF) scale at baseline, when participants were in remission for 3–6 months. ES-SCZ was calculated based on previously validated estimates and included childhood adversity domains (emotional and physical neglect; emotional, physical and sexual abuse; and bullying), cannabis use, hearing impairment, and winter birth. The association between ES-SCZ and GAF was evaluated in three multiple linear regression models, with each successive model including additional covariates.</div></div><div><h3>Results</h3><div>ES-SCZ was negatively associated with the GAF score, even after accounting for age, sex at birth, education, migrant status, antipsychotic type, and FEP duration [B = −1.51 (−2.78 to −0.24), <em>p</em> = .022]. This final model explained 8.6 % of the variance (R<sup>2</sup>) in the GAF score, with ES-SCZ being the primary contributor, accounting for 35.5 % of this explained variance.</div></div><div><h3>Conclusions</h3><div>This study independently replicated the finding that ES-SCZ predicts general functioning in FEP, showing its potential for forecasting functioning in remitted FEP patients.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 223-231"},"PeriodicalIF":3.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender-specific group cognitive behavioral therapy for women with at-risk mental state: A randomized controlled trial 针对高危精神状态女性的性别群体认知行为疗法:一项随机对照试验。
IF 3.5 2区 医学
Schizophrenia Research Pub Date : 2025-10-06 DOI: 10.1016/j.schres.2025.09.027
Eric Y.H. Chen , Agatha W.S. Wong , Jade P.S. Wong , Komi Y.K. Li , Michael T.H. Wong , Stephanie M.Y. Wong , Natalie H.T. Wong , Sherry K.W. Chan , Yi-Nam Suen , Christy L.M. Hui
{"title":"Gender-specific group cognitive behavioral therapy for women with at-risk mental state: A randomized controlled trial","authors":"Eric Y.H. Chen ,&nbsp;Agatha W.S. Wong ,&nbsp;Jade P.S. Wong ,&nbsp;Komi Y.K. Li ,&nbsp;Michael T.H. Wong ,&nbsp;Stephanie M.Y. Wong ,&nbsp;Natalie H.T. Wong ,&nbsp;Sherry K.W. Chan ,&nbsp;Yi-Nam Suen ,&nbsp;Christy L.M. Hui","doi":"10.1016/j.schres.2025.09.027","DOIUrl":"10.1016/j.schres.2025.09.027","url":null,"abstract":"<div><div>Gender differences in individuals at risk mental state (ARMS) highlight the need for mental health service tailored to gender-specific needs. While Cognitive Behavioral Therapy (CBT) is recognized as an effective intervention for psychotic disorders and ARMS, research on gender-specific CBT for ARMS is limited. This study compares the effects of group CBT with psychoeducation on functional and symptomatic outcomes, and the likelihood of transition to psychosis, in women with ARMS. One hundred and Seventy-eight women with ARMS were recruited and randomly assigned to either women-specific group CBT or psychoeducation. Functioning and symptomatic outcomes were assessed at baseline and post-intervention, and transition to psychosis was evaluated 12 months after the initial assessment.</div><div>Both interventions showed significant improvements in overall functioning and reductions in delusion severity but without a significant interaction between the groups. However, participants who completed the full course of group CBT exhibited substantial improvements in overall functioning and a notable reduction in auditory hallucinations compared to the psychoeducation group. None of the participants developed psychosis during the treatment period or the 12-month follow-up. The findings suggest that group CBT can effectively enhance functional and symptomatic outcomes, provided a sufficient intervention dosage is maintained.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 215-222"},"PeriodicalIF":3.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Smartphone intervention apps for schizophrenia: A review of the academic literature and app stores 精神分裂症的智能手机干预应用:学术文献和应用商店综述
IF 3.5 2区 医学
Schizophrenia Research Pub Date : 2025-10-03 DOI: 10.1016/j.schres.2025.09.007
Winna Xia , Christine Hau , James Burns , Sean Ryan , Joseph Firth , Jake Lineradon , John Torous
{"title":"Smartphone intervention apps for schizophrenia: A review of the academic literature and app stores","authors":"Winna Xia ,&nbsp;Christine Hau ,&nbsp;James Burns ,&nbsp;Sean Ryan ,&nbsp;Joseph Firth ,&nbsp;Jake Lineradon ,&nbsp;John Torous","doi":"10.1016/j.schres.2025.09.007","DOIUrl":"10.1016/j.schres.2025.09.007","url":null,"abstract":"<div><h3>Background</h3><div>While the interest and use of apps for anxiety and depression accelerated with COVID-19, less is known about the status of apps for people with schizophrenia and psychosis-spectrum disorders. This study aims to offer a comprehensive overview of the research and commercial app marketplaces (Apple, Android) to assess how recent technological advances translate into tools patients can use today.</div></div><div><h3>Methods</h3><div>In December 2024, we conducted a narrative review for apps related to schizophrenia and coded a brief overview of the studies, eligibility, outcomes and experiences, engagement and features, attrition and adherence, and app availability. We simultaneously conducted a search on the U.S. Google Play and the U.S. Apple App Store for apps denoted in the research literature and other commercially available apps.</div></div><div><h3>Results</h3><div>The academic literature search yielded 3753 articles, of which 34 were included. Across these 34 studies, 32 unique apps related to schizophrenia and psychosis were featured. A search of the U.S. app marketplaces yielded only one relevant app peer-reviewed in the last decade and that was broadly accessible to patients.</div></div><div><h3>Conclusion</h3><div>To realize the full clinical utility of these apps, it is essential to shift the focus toward their specific features and functionalities, supported by more rigorous research and follow-up studies. There is a pressing need for greater standardization in outcome measures and record-keeping practices to ensure consistency and reliability across the field. While the number of commercially available apps has increased, the lack of robust, large-scale controlled studies and standardized controls has resulted in inconsistent findings. Findings highlight the importance of conducting more controlled studies and randomized clinical trials with appropriate controls to strengthen the evidence base and guide the effective implementation of digital health interventions in mental health care.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 204-214"},"PeriodicalIF":3.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Positive symptoms and medication adherence in response to oral versus long-acting injectable risperidone in black, latino, and white first-episode psychosis patients" [Schizophr Res. (2025) 160-166]. “黑人、拉丁裔和白人首发精神病患者口服与长效注射利培酮的阳性症状和药物依从性”的更正[精神分裂症,(2025)160-166]。
IF 3.5 2区 医学
Schizophrenia Research Pub Date : 2025-10-03 DOI: 10.1016/j.schres.2025.09.026
Derek M Novacek, Kenneth L Subotnik, Joseph Ventura, Laurie R Casaus, Fiona Whelan, Catherine A Sugar, Keith H Nuechterlein
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