Schizophrenia Research最新文献

{"title":"Toxoplasmosis infection and schizophrenia: Elevated IgM reactivity index as a predictor of symptom worsening in chronic schizophrenia","authors":"Pedro H.P. Alvim ,&nbsp;Victoria C. Cavalari ,&nbsp;Ana J. Bianchini ,&nbsp;Gabriela Ferreira Frizon ,&nbsp;Gabriela Mourao Ferreira ,&nbsp;Helena Fabiane Huth Savian ,&nbsp;Isabela Drehmer ,&nbsp;Jéferson Ferraz Goularte ,&nbsp;Luiz F.C. Garcia ,&nbsp;Marcelo Carriello ,&nbsp;Mariane Noto ,&nbsp;Monise Costanzi ,&nbsp;Rafael Amaral Donassolo ,&nbsp;Vanessa Ota ,&nbsp;Vitória G. Berlitz ,&nbsp;Cristiano Noto ,&nbsp;Sintia Belangero ,&nbsp;Ary Gadelha ,&nbsp;Clarissa S. Gama ,&nbsp;Letusa Albrecht ,&nbsp;Raffael Massuda","doi":"10.1016/j.schres.2025.03.008","DOIUrl":"10.1016/j.schres.2025.03.008","url":null,"abstract":"<div><div>The association between schizophrenia and toxoplasmosis has been studied for decades; however, most studies have small sample sizes, and few have investigated the relationship between toxoplasmosis and schizophrenia symptoms. This study aimed to compare the prevalence of toxoplasmosis seropositivity between schizophrenia patients and healthy controls in a large Brazilian sample and to investigate the association between IgM and IgG reactivity index (RI) and the severity of schizophrenia symptoms. A multicenter, cross-sectional study assessed Positive and Negative Symptoms Scale from patients, seropositivity to toxoplasmosis as well as serointensity (RI) of IgM and IgG from blood samples of 705 subjects: 313 healthy controls and 392 schizophrenia patients (313 chronic patients and 76 first episode of psychosis). The prevalence of seropositivity to toxoplasmosis was higher in schizophrenia than in controls (OR of 1.52, 95 % CI 1.11–2.07, <em>p</em> = .008), especially in those in FEP (OR = 1.99, 95 % CI 1.02–2.97, <em>p</em> = .042). Also, IgM RI was positively associated with the PANSS total (<em>p</em> = .012, R² = 0.17), positive (<em>p</em> = .017, R² = 0.17), and general scores (<em>p</em> = .018, R² = 0.14) in chronic patients. Toxoplasmosis is associated with schizophrenia, especially in patients in their first psychotic episode; moreover, RI of IgM was positively associated with the severity of the psychosis in chronic patients, which suggests that new infection may worsen symptomatology.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"278 ","pages":"Pages 20-25"},"PeriodicalIF":3.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brief video intervention to reduce stigma of family and friends of people living with serious mental illness","authors":"Doron Amsalem ,&nbsp;Samantha E. Jankowski ,&nbsp;John C. Markowitz ,&nbsp;Philip Yanos ,&nbsp;Lisa B. Dixon","doi":"10.1016/j.schres.2025.03.011","DOIUrl":"10.1016/j.schres.2025.03.011","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"278 ","pages":"Pages 17-19"},"PeriodicalIF":3.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of treatment response in drug-naïve schizophrenia patients from the perspective of targeted metabolomics","authors":"Shuo Wang ,&nbsp;Yeqing Dong ,&nbsp;Yuying Qiu ,&nbsp;Xiaoxiao Sun,&nbsp;Changyong Jiang,&nbsp;Qiao Su,&nbsp;Meijuan Li,&nbsp;Jie Li","doi":"10.1016/j.schres.2025.03.016","DOIUrl":"10.1016/j.schres.2025.03.016","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia (SZ) is a severe and chronic mental illness affecting approximately 1 % of the global population. Although antipsychotic medications can alleviate some symptoms, 20‐–30 % of patients exhibit resistance to available treatments. Therefore, identifying objective biomarkers related to treatment efficacy is crucial.</div></div><div><h3>Methods</h3><div>A total of 56 drug-naïve SZ patients were recruited, and after 8 weeks of antipsychotic medication, they were classified as treatment responders (30) and non-responders (26) based on the improvement of their symptoms. Baseline plasma metabolites were measured by targeted metabolomics Biocrates MxP® Quant 500 Kit.</div></div><div><h3>Results</h3><div>A total of 271 metabolites were identified, among which 31 exhibited significant differences between responders and non-responders, including phosphatidylcholine (PC) (14), sphingomyelin (8), ceramide (6), cholesteryl ester (2), and sarcosine (1), which were mainly concentrated in the sphingolipid metabolic pathway. Notably, key differential metabolites included phosphatidylcholine, sphingomyelin, and ceramide, which were predominantly enriched in the sphingolipid metabolism pathway. Through logistic regression analysis, sarcosine, PC aa C28:1, PC ae C34:2, and PC ae C36:3 emerged as significant predictors, yielding a combined area under the curve (AUC) of 0.877 for effectively distinguishing treatment responders from non-responders.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that the combination of sarcosine, PC aa C28:1, PC ae C34:2, and PC ae C36:3 could serve as biomarkers for prediction of treatment response in patients with drug-naïve SZ.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"278 ","pages":"Pages 9-16"},"PeriodicalIF":3.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LEPR gene polymorphisms and pneumonia risk in Taiwanese schizophrenia patients under clozapine treatment","authors":"Hui-Ching Huang ,&nbsp;Bo-Jian Wu ,&nbsp;Chuan-Hsun Yu ,&nbsp;Chao-Zong Liu ,&nbsp;Lawrence Shih-Hsin Wu","doi":"10.1016/j.schres.2025.03.014","DOIUrl":"10.1016/j.schres.2025.03.014","url":null,"abstract":"<div><h3>Background</h3><div>Clozapine, the preferred medication for treatment-resistant schizophrenia, elevates leptin and pro-inflammatory cytokine levels in patients' blood. Inhibition of the clozapine metabolic enzyme CYP1A2 can potentially lead to toxicity and pneumonia. Leptin has a pro-inflammatory effect on the immune system. This study explores whether polymorphisms in the leptin (<em>LEP</em>) and leptin receptor (<em>LEPR</em>) genes are associated with increased risk of clozapine-induced pneumonia.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted with 302 consecutive schizophrenia patients who had been on clozapine for at least 6 months. Blood samples were collected to identify genetic polymorphisms in the <em>LEP</em> and <em>LEPR</em> genes, and the association between these polymorphisms and pneumonia incidence was analyzed using Cox proportional hazards models.</div></div><div><h3>Results</h3><div>Among the SNPs in the <em>LEPR</em> gene, individuals with the A/A genotype of rs1137101 had a 14.96-fold higher pneumonia risk than those with the G/G genotype (<em>p</em> = 0.001). Carriers of the G/G genotype of rs1805096 had a 3.72-fold increased risk compared to those with A/A (<em>p</em> = 0.033). For rs6657868, the A/G and G/G genotypes were associated with 2.23-fold (<em>p</em> = 0.005) and 6.73-fold (<em>p</em> = 0.013) higher risks, respectively, compared to the A/A genotype. Similarly, for rs9436746, the A/C and C/C genotypes had 2.25-fold (<em>p</em> = 0.005) and 5.37-fold (<em>p</em> = 0.029) increased risks, respectively, compared to A/A.</div></div><div><h3>Conclusion</h3><div><em>LEPR</em> polymorphisms associated with an increased risk of pneumonia in Taiwanese schizophrenia patients treated with clozapine.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"278 ","pages":"Pages 1-8"},"PeriodicalIF":3.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of microdosing in clinical high-risk populations","authors":"Claire E. Bertrand,&nbsp;Vijay A. Mittal","doi":"10.1016/j.schres.2025.03.017","DOIUrl":"10.1016/j.schres.2025.03.017","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social and environmental factors during the smoking cessation process: The experiences of adults with serious mental illnesses","authors":"Heather Leutwyler ,&nbsp;Jeremiah Mock ,&nbsp;Erin Hubbard ,&nbsp;Theodore Bussell ,&nbsp;Negin Zahedikia ,&nbsp;Nikta Vaghar ,&nbsp;Dennys Balestra ,&nbsp;Sophia Wuest ,&nbsp;Meg Wallhagen ,&nbsp;Chizimuzo Okoli","doi":"10.1016/j.schres.2025.03.010","DOIUrl":"10.1016/j.schres.2025.03.010","url":null,"abstract":"<div><h3>Introduction</h3><div>People living with schizophrenia and other serious mental illnesses (SMI) face a disproportionate burden of tobacco-related prevalence and, consequently, tobacco-induced morbidity, in comparison to those without SMI. Social and environmental factors play an important role in the health of people with SMI yet less is known about the role of these factors in smoking cessation interventions for adults with SMI. The purpose of this paper is to analyze the social and environmental factors that contributed to the smoking cessation process among adults with SMI enrolled in a smoking cessation program.</div></div><div><h3>Methods</h3><div>We conducted semi-structured qualitative interviews with 30 adults (mean age 47.0, sd 12.2) living with SMI, upon completion of a 12-week smoking cessation program. Grounded Theory methodology guided data collection and analysis.</div></div><div><h3>Results</h3><div>Participants described what contributed to their success with smoking cessation or reduction and elucidated how <em>social and environmental factors</em> played a role in the process. Two broad categories of the social determinants of smoking cessation evolved from the data: 1) support and belonging; and 2) environment, including both the physical and broader sociopolitical.</div></div><div><h3>Discussion/conclusion</h3><div>Our findings illustrate the importance of including social and environmental contexts in health interventions and serve as a reminder to consider social determinants of health when tailoring interventions to meet the unique needs of people living with SMI. These findings can inform the development of tobacco cessation programs in mental health programs, such as the need to incorporate group-based social support, nature-friendly environments, and social activities in the process of cessation.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 111-116"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with clinically relevant weight loss in men and women with psychotic disorders","authors":"P. Di Prinzio,&nbsp;Vera A. Morgan,&nbsp;A. Waterreus","doi":"10.1016/j.schres.2025.03.007","DOIUrl":"10.1016/j.schres.2025.03.007","url":null,"abstract":"<div><div>Weight gain presents a substantial problem for people with psychotic disorders. Three quarters of individuals are overweight or obese and those starting antipsychotics experience rapid weight gain in the first 6–12<!--> <!-->months of treatment and this weight gain does not appear to plateau. The high prevalence of modifiable lifestyle risk factors and antipsychotic medication use all contribute to the increased risk of weight gain and cardiovascular disease. Sex may also play a role in the amount of weight gained. Crucially, a 5–10 % reduction in weight has a positive impact on cardiovascular disease risk factors.</div><div>This study aimed to investigate clinically relevant weight loss (CRWL) and its associated factors, separately by sex. This naturalistic longitudinal study examined the weight of 372 men and women with psychotic disorders at baseline and follow-up on average 3.3 years later and compared those who had lost ≥7 % of their baseline weight with those who had not. Results showed 20.3 % of men and 19.9 % of women had CRWL and a different set of factors were observed to be associated with CRWL for each sex. For men, older age, higher baseline weight, and stopping use of antipsychotics compared to use of antipsychotics with a high-risk of weight gain were associated with an increased odds of CRWL. For women, only better quality of sleep was associated with an increased odds of CRWL. Greater understanding of the factors associated with weight loss in men and women with psychotic disorders may inform the development and implementation of targeted strategies.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 102-110"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis","authors":"Katrina Aberizk ,&nbsp;Esra Sefik ,&nbsp;Qingyue Yuan ,&nbsp;Hengyi Cao ,&nbsp;Jean M. Addington ,&nbsp;Carrie E. Bearden ,&nbsp;Kristin S. Cadenhead ,&nbsp;Tyrone D. Cannon ,&nbsp;Barbara A. Cornblatt ,&nbsp;Matcheri Keshavan ,&nbsp;Daniel H. Mathalon ,&nbsp;Diana O. Perkins ,&nbsp;William S. Stone ,&nbsp;Scott W. Woods ,&nbsp;Elaine F. Walker ,&nbsp;Benson S. Ku","doi":"10.1016/j.schres.2025.02.012","DOIUrl":"10.1016/j.schres.2025.02.012","url":null,"abstract":"<div><div>Temporoparietal brain areas comprise a candidate set of regions for interrogating the brain functional correlates of socioenvironmental factors in people at clinical high-risk for psychosis (CHR-P). Temporal lobe abnormalities have been shown to be common among people with schizophrenia spectrum conditions. Further, temporoparietal brain regions are implicated in tasks relevant to psychosocial outcomes, including coherent autobiographical memory recall and multimodal integration. This report examined relations of hippocampal-temporoparietal functional connectivity with neighborhood-level social fragmentation, a composite of area-level characteristics that measures social cohesion, among youth at CHR-P and healthy comparisons in the second wave of the North American Prodrome Longitudinal Study (<em>n</em> = 146, age = 19.9 ± 3.9, 47 % female). This study also examined whether those relations were moderated by individual-level social engagement in desirable activities. Significant positive relations of neighborhood-level social fragmentation and hippocampal functional connectivity with the superior temporal pole were observed among participants at CHR-P. Moderation analyses demonstrated that those relations were significant only at low and mean levels of individual-level social engagement in participants at CHR-P. Findings contribute to the literature indicating that adverse environmental factors are associated with deviant patterns of brain connectivity. This exploratory research also contributes to future theorizing about neurobiological mechanisms underlying therapeutic interventions involving social engagement that have demonstrated improved functional outcomes for people with psychotic disorders.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 151-158"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in degree centrality and its associated genes: A longitudinal study of patients with schizophrenia undergoing pharmacological treatment","authors":"Linna Zhang ,&nbsp;Chunguo Zhang ,&nbsp;Haohao Yan ,&nbsp;Yiding Han ,&nbsp;Caixia Xu ,&nbsp;Jiaquan Liang ,&nbsp;Runyi Li ,&nbsp;Ningning Chen ,&nbsp;Wenting Liang ,&nbsp;Wei Huang ,&nbsp;Guojun Xie ,&nbsp;Wenbin Guo","doi":"10.1016/j.schres.2025.03.009","DOIUrl":"10.1016/j.schres.2025.03.009","url":null,"abstract":"<div><h3>Background</h3><div>The role of degree centrality (DC) in schizophrenia (SCZ), its trajectory following pharmacological treatment, and its potential as a prognostic biomarker and genetic mechanism remain unclear.</div></div><div><h3>Methods</h3><div>We recruited 51 healthy controls (HC) and 56 patients with SCZ. Additionally, the SCZ patients underwent three months of antipsychotic medication treatment. We collected resting-state functional magnetic resonance imaging data, clinical variables, and conducted analyses using support vector machines, support vector regression, and gene expression correlation analysis.</div></div><div><h3>Results</h3><div>Our study revealed that SCZ patients had generally reduced DC values in the cerebral cortex compared to HC at baseline, with increased DC values observed in the left occipital gyrus. After three months of treatment, SCZ patients exhibited a significant decrease in DC values in the left fusiform gyrus and an increase in the left inferior parietal gyrus. Variations in DC values in SCZ patients were associated with multiple genes, primarily enriched in molecular functions.</div></div><div><h3>Conclusion</h3><div>Changes in DC values in the right inferior occipital/fusiform gyrus and right calcarine/middle occipital gyrus may serve as neuroimaging markers to differentiate between HC and SCZ patients. Additionally, DC values in the left middle/postcentral gyrus could be used to predict treatment outcomes. Transcriptome-neuroimaging spatial correlation analysis provides valuable insights into the neurobiological mechanisms underlying SCZ pathology.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 130-139"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of visual remediation on Ebbinghaus illusion task performance in people with schizophrenia: A preliminary study","authors":"Kaitlyn A. Kaiser ,&nbsp;Judy L. Thompson ,&nbsp;Pamela D. Butler ,&nbsp;Anthony O. Ahmed ,&nbsp;Aaron R. Seitz ,&nbsp;Tarek Sobeih ,&nbsp;Steven M. Silverstein","doi":"10.1016/j.schres.2025.02.011","DOIUrl":"10.1016/j.schres.2025.02.011","url":null,"abstract":"<div><h3>Background</h3><div>Atypical perception of visual illusions is well-documented in schizophrenia (SZ) and thought to be a consequence of impairments in visual processes including perceptual organization (PO). The Ebbinghaus illusion, in which a circle appears larger or smaller depending on the size of surrounding circles, is facilitated by PO, and the extent to which the surrounds (i.e., context) influence perception of the center circle can be considered an index of <em>context sensitivity</em>. In the present study, as part of a broader investigation of the impact of a novel visual remediation (VR) program for people with SZ, the Ebbinghaus illusion was used to explore the effects of VR on context sensitivity.</div></div><div><h3>Methods</h3><div>Participants with SZ (<em>n</em> = 47) were randomly assigned to one of four conditions: VR only, an active control condition (AC), or one of two conditions combining VR and AC. At three assessment points, participants completed a size comparison task based on the Ebbinghaus illusion. Context sensitivity was compared between training groups and with baseline clinical characteristics.</div></div><div><h3>Results</h3><div>At baseline, participants were strongly context sensitive. After training, participants in the VR group, but not the AC-only group, became less influenced by context. The main effect of training group and the group × time interaction terms were not significant. Participants who were less symptomatic at baseline showed the greatest reductions in context sensitivity over time.</div></div><div><h3>Conclusions</h3><div>These findings suggest that an adaptive reduction in the influence of irrelevant context is a potential effect of VR and may reflect improved attentional focus.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 57-64"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}