Schizophrenia Research最新文献

{"title":"Implementation of a digital measurement-based care approach in an early intervention service for psychosis: the PEPP-Montreal electronic data capture protocol and its alignment with learning health system principles","authors":"Elissa Zavaglia ,&nbsp;Ridha Joober ,&nbsp;Srividya N. Iyer ,&nbsp;Kevin MacDonald ,&nbsp;Martin Lepage ,&nbsp;Sherezad Abadi ,&nbsp;Jai Shah ,&nbsp;Manuela Ferrari","doi":"10.1016/j.schres.2025.05.021","DOIUrl":"10.1016/j.schres.2025.05.021","url":null,"abstract":"<div><div>Measurement-based care, crucial for improving outcomes in psychiatric disorders, remains underutilized, particularly during the impactful early treatment phases. Inspired by a learning health system approach, a hybrid paper/electronic data capture platform was developed at PEPP-Montreal, an early psychosis program, gathering data on patient socio-demographics, symptoms, functioning, pathways to care, substance use, and medication monitoring. This article evaluates the year-one deployment of this innovative infrastructure (2022−2023). The novel 2022 hybrid infrastructure was compared with the 2016 paper-based version, using the RE-AIM framework (Reach, Effectiveness, Adoption, Implementation, and Maintenance). Phase 1 identified evidence-based clinical measures including patient-reported, clinician-reported, and evaluator-reported outcomes, while phase 2 further streamlined and implemented the electronic data capture platform. Continuous data collection through the platform was deployed at six time points. Results included: <em>Reach</em>: <em>N</em> = 53/81 patients used paper/electronic data for their year-one service evaluation. <em>Effectiveness:</em> The automated, hybrid paper/electronic protocol optimized data management. <em>Adoption:</em> Rates of electronic patient-reported outcomes were higher in 2022–2023 than 2016–2017 (paper version). Completion rates for clinician-reported outcomes were highest at baseline (year-one). <em>Implementation/maintenance</em>: Barriers and facilitators, essential adaptations, and sustainable impacts were identified. Using electronic, measurement-based data collection accelerates feedback closer to real time and alignment with learning health system principles. Implementing the hybrid data collection platform at PEPP-Montreal provided valuable insights into using measurement-based care to inform quality of services. In the complex transition to a digital protocol within a learning health system, including engagement of key stakeholders, using the hybrid protocol was a necessary first step.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"282 ","pages":"Pages 141-149"},"PeriodicalIF":3.6,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective emotional experiences in clinical high-risk youth: Insights from a dyadic interaction paradigm","authors":"Madison Stevens ,&nbsp;Jessica Fattal ,&nbsp;Danielle Pratt ,&nbsp;Lillian X. Fu ,&nbsp;Claudia M. Haase ,&nbsp;Vijay A. Mittal","doi":"10.1016/j.schres.2025.06.011","DOIUrl":"10.1016/j.schres.2025.06.011","url":null,"abstract":"<div><div>Alterations in emotional functioning are a characteristic symptom of psychotic disorders. The clinical high-risk (CHR) period provides an important time for investigating early mechanisms, and their relation to psychosis vulnerability. However, our understanding of subjective emotional experiences in this critical population, particularly contextualized within social interactions, is limited. To address this gap, the present study aimed to evaluate subjective emotional experiences in CHR youth (12−30) using an experimental dyadic interaction paradigm. The sample included 148 individuals, 36 CHR-Partner dyads and 41 Control-Partner dyads, who engaged in three 10-min dyadic interactions (i.e., neutral, conflict, and pleasant). Following each conversation, participants reported the intensity of their positive and negative emotional experiences. Participants also completed a series of structured clinical interviews. CHR youth reported greater negative emotional experiences following pleasant conversations than control youth (U(74) = 533.5, <em>p</em> = 0.035). In CHR youth, greater negative emotional experiences following neutral conversations were associated with greater positive (<em>r</em>_s = 0.37,p_corr = 0.046) and negative (<em>r</em>_s = 0.44, p_corr = 0.038) psychosis-risk symptoms. Significant differences between CHR and control dyads were found for youth-partner discrepancies in positive emotional experiences following neutral (U(72) = 883, p_corr = 0.014) and conflict (t(72) = 3.28, <em>p</em> &lt; 0.005) conversations as well as negative emotional experiences following neutral (U(72) = 914, p &lt; 0.005) and pleasant (U(71) = 855.5, <em>p</em> = 0.043) conversations. Greater discrepancies in negative emotional experiences between CHR youth and partners following the neutral conversation were associated with greater negative symptoms (<em>r</em>_s = −0.42, <em>p</em> &lt; 0.05). These results provide understanding into mechanisms driving socioemotional functioning in CHR individuals and can inform interventions that target close relationships to improve outcomes.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"282 ","pages":"Pages 133-140"},"PeriodicalIF":3.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered neural oscillations are associated with improved working memory performance in schizophrenia following D-cycloserine administration","authors":"Emma Mirhashemi ,&nbsp;Peter Bachman ,&nbsp;Giri Krishnan ,&nbsp;Robert F. Asarnow ,&nbsp;Jennifer K. Forsyth","doi":"10.1016/j.schres.2025.06.001","DOIUrl":"10.1016/j.schres.2025.06.001","url":null,"abstract":"<div><div>Cognitive deficits, such as impaired working memory, are a core feature of schizophrenia and a key target for intervention that have been hypothesized to reflect hypofunction at the <em>N</em>-methyl-<span>d</span>-aspartate glutamate receptor (NMDAR). Working memory depends on neural oscillations in the gamma (30–80 Hz), theta (4–7 Hz), and alpha (8–13 Hz) frequency bands, with gamma oscillations known to be strongly impacted in schizophrenia and to be sensitive to NMDAR hypofunction. Importantly, in a previous double-blind randomized placebo-controlled study, findings suggested that <em>n</em>-back working memory performance was improved in schizophrenia patients who received 100 mg of the NMDAR agonist D-cycloserine (SZ-DCS; <em>n</em> = 17) compared to patients who received placebo (SZ-placebo; <em>n</em> = 16; Forsyth et al., 2017). To understand potential mechanisms underlying this effect, the current study examined electroencephalogram data collected during this study to identify whether gamma, theta, and alpha oscillations were altered in patients who received DCS versus placebo. Results revealed reduced working memory-related gamma power in right frontal and occipital channels from 1 to 1.5 s post-stimulus onset in SZ-DCS versus SZ-placebo patients. SZ-DCS patients also showed reduced frontal theta power relative to SZ-placebo patients across memory loads. Conversely, SZ-DCS patients showed increased left-hemisphere alpha power during the 0-back control condition, without differences during working memory loads. Our findings suggest that increasing NMDAR signaling in schizophrenia may improve working memory performance by increasing the efficiency of gamma and theta oscillations that support working memory demands, as well as enhancing alpha oscillations that support preparatory attentional processes.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"282 ","pages":"Pages 85-94"},"PeriodicalIF":3.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the cumulative incidence of treated schizophrenia and predictors of transition in an early intervention for psychosis service","authors":"Brian O'Donoghue ,&nbsp;Scott Eaton ,&nbsp;John Lyne ,&nbsp;Andrew Thompson ,&nbsp;Patrick McGorry","doi":"10.1016/j.schres.2025.06.005","DOIUrl":"10.1016/j.schres.2025.06.005","url":null,"abstract":"<div><h3>Background</h3><div>The accurate measurement of the incidence of schizophrenia can inform public policy and ensure equitable allocation of limited resources. First contact cases under-estimates the true incidence because of later transitions to schizophrenia. This study aimed to determine the:(i)24 months cumulative incidence of treated DSM-5 schizophrenia diagnosed during treatment at the Early Psychosis Prevention and Intervention Centre (EPPIC) service by including cases of first episode psychosis (FEP) which subsequently transitioned to a diagnosis of schizophrenia; (ii) extent of the under-estimation by using first contact cases; and (iii) proportion and predictors of transition to schizophrenia or bipolar disorder.</div></div><div><h3>Methods</h3><div>This observational study included all consecutive cases of FEP for people aged 15–24 who attended the EPPIC service from 2011 to 2016, data was recorded prospectively but collected by researchers retrospectively. Poisson regression and Cox regression were used to determine incidence rate ratios and hazard ratios respectively.</div></div><div><h3>Results</h3><div>At presentation, of the 1220 young people with a FEP, 17.2 % had a diagnosis of schizophrenia compared to 30.2 % after a median of 93 weeks (I.Q.R.: 62–106). The incidence rates of first contact diagnosis of schizophrenia ranged from 17.6 to 28.2 per 100,000 and the cumulative incidence rate ranged from 28.2 to 42.3. The incidence of schizophrenia was 57 % higher with the cumulative method (IRR = 1.57,95%C.I.: 1.30–1.90,<em>p</em> &lt; .001). At discharge, 30.2 % met criteria for schizophrenia and 16.3 % for bipolar disorder.</div></div><div><h3>Conclusions</h3><div>Even when considering the limitations of the study, such as the narrow age bracket of the participants, the cumulative incidence of schizophrenia should be used to determine a more accurate incidence.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"282 ","pages":"Pages 116-122"},"PeriodicalIF":3.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of symptomatic and wellbeing remission in real-world samples of patients living with schizophrenia treated with aripiprazole once-monthly by means of constrained confidence partitioning","authors":"Christoph U. Correll ,&nbsp;Wolfgang Janetzky ,&nbsp;Andreas Brieden","doi":"10.1016/j.schres.2025.06.004","DOIUrl":"10.1016/j.schres.2025.06.004","url":null,"abstract":"<div><h3>Introduction</h3><div>An important goal in the treatment of patients living with schizophrenia is to achieve remission of schizophrenia symptoms and patient well-being. The possibility to predict which patients will achieve remission may inform treatment decisions. We derived different models for this on the basis of data from a German real-world study, part of which were tested for their predictive power by independent data obtained from a similar Canadian study.</div></div><div><h3>Methods</h3><div>Here, we used a sample of patients living with schizophrenia who participated in a 6-month non-interventional study of aripiprazole once-monthly. Data of patients with complete datasets (<em>n</em> = 194) were used to predict remission of symptoms (cross-sectional Andreasen criteria as measured by the Brief Psychiatric Rating Scale, BPRS) and well-being (as measured by the WHO-5 well-being index) at 6 months using logistic regression as well as the constrained confidence partitioning (c²p) method.</div></div><div><h3>Results</h3><div>Logistic regression yielded a model with the variables remission stats at baseline, Global Assessment of Functioning (GAF) score at baseline and age. Quality indicators suggested acceptable model quality, and we were able to validate the model using external data from the Canadian study. Models for remission of well-being and combined remission of symptoms and well-being were of poor quality. Modeling using c²p yielded defined groups of patients with differential likelihoods of achieving remission of symptoms, well-being, or both. In general, patients with lower scores in core symptoms, higher GAF scores, younger age, and higher WHO-5 scores showed increased likelihoods of achieving remission. The c²p model of symptomatic remission was also validated using external data from the Canadian study, and we demonstrated the possibility to generate and test hypotheses based on the model.</div></div><div><h3>Conclusion</h3><div>Despite only using a comparatively small sample, both logistic regression and c²p can produce reliable results with mathematically desirable properties. Patients with less severe core symptoms, better functioning, younger age, and better well-being may achieve symptomatic remission and remission of well-being more easily than other patients. The latter may need additional interventions in order to achieve remission.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"282 ","pages":"Pages 105-113"},"PeriodicalIF":3.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter to the editor: Aripiprazole or metformin for hyperprolactinemia in women with schizophrenia: A 6-month, real-world chart review study","authors":"Jie Yang,&nbsp;Xuequan Zhu,&nbsp;Le Xiao","doi":"10.1016/j.schres.2025.06.006","DOIUrl":"10.1016/j.schres.2025.06.006","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"282 ","pages":"Pages 114-115"},"PeriodicalIF":3.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic overlap between household income and psychiatric disorders","authors":"Jianfei Zhang ,&nbsp;Guangxing Zhang ,&nbsp;Qiyu Zhao ,&nbsp;Yanmin Peng","doi":"10.1016/j.schres.2025.05.012","DOIUrl":"10.1016/j.schres.2025.05.012","url":null,"abstract":"<div><div>Household income (HI), a significant socioeconomic factor influencing mental health, has seen its association with various mental disorders garnering increasing attention. However, the common genetic basis between HI and psychiatric disorders remains poorly understood. Utilizing genome-wide association study (GWAS) pooled statistics for HI, schizophrenia (SCZ), attention deficit hyperactivity disorder (ADHD), bipolar disorder (BIP), and autism spectrum disorders (ASD), bivariate mixed models of causality (MiXeR) were employed to quantify the shared genetic architecture between HI and psychiatric disorders. The conjunctional false discovery rate (conjFDR) approach was utilized to identify specific shared loci, and the resulting shared genetic loci were analyzed for functional annotation and gene set enrichment. The MiXeR analysis revealed that among the 8.9 K variants affecting HI, 8.7 K were shared with SCZ, 7.8 K with ADHD, 6.2 K with BIP, and 8.7 K with ASD. A total of 344 shared genetic loci were identified between HI and psychiatric disorders using the conjFDR method, with 254 of them being novel. Additionally, the shared loci of HI with SCZ and ADHD mainly demonstrated opposite effect directions, while those with BIP and ASD mainly exhibited mixed effect directions. Functional annotation indicated that the shared genetic loci were predominantly located in intronic and intergenic regions, and enrichment analysis demonstrated that they were involved in nervous system development, multicellular organism development, and neuron differentiation. In conclusion, our study reveals a shared genetic architecture between HI and psychiatric disorders, highlighting common biological processes that may contribute to understanding their complex etiologies and overlapping genetic mechanisms.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"282 ","pages":"Pages 95-104"},"PeriodicalIF":3.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disturbances in individuals with first episode psychosis and clinical high-risk states: A systematic review","authors":"Valentina Baldini ,&nbsp;Francesco Pasquino ,&nbsp;Diana De Ronchi ,&nbsp;Giuseppe Plazzi ,&nbsp;Lorenzo Pelizza ,&nbsp;Marco Menchetti","doi":"10.1016/j.schres.2025.06.008","DOIUrl":"10.1016/j.schres.2025.06.008","url":null,"abstract":"<div><h3>Background</h3><div>Sleep disturbances are increasingly recognized as relevant components of the psychopathology of psychosis, emerging early in the illness trajectory and persisting over time. Indeed, individuals with first-episode psychosis (FEP) commonly experience disruptions in sleep architecture, including reduced sleep efficiency, increased sleep latency, and altered time spent in various sleep stages. These abnormalities are also reported in individuals with Clinical High-Risk (CHR) states, showing a significant correlation with cognitive and affective impairments.</div></div><div><h3>Methods</h3><div>We conducted a systematic search across four main electronic databases, including PubMed, Web of Science, EMBASE, and PsycINFO, to specifically identify studies examining sleep parameters in FEP and CHR subjects compared to healthy controls. Eligibility criteria included quantitative and qualitative assessments of sleep.</div></div><div><h3>Results</h3><div>The final selection consisted of 25 studies corresponding to 1255 patients and 342 healthy controls. Increased sleep latency and alterations in slow-wave sleep were frequently reported. These findings highlight the pervasiveness of sleep disturbances in individuals with early psychosis, though further research is needed to clarify their clinical significance. Evidence also suggests bidirectional relationships between sleep disturbances and psychotic symptoms, with sleep disruptions potentially exacerbating cognitive and emotional dysfunctions in FEP and CHR individuals.</div></div><div><h3>Conclusions</h3><div>Sleep disturbances in FEP/ CHR populations are pervasive and may reflect underlying neurobiological mechanisms implicated in psychosis. These abnormalities represent modifiable targets for early intervention, with the potential to improve clinical and functional outcomes. Future research should explore longitudinal associations and the efficacy of sleep-focused interventions in the early stages of psychotic disorders.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"282 ","pages":"Pages 123-132"},"PeriodicalIF":3.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Aripiprazole or metformin for hyperprolactinemia in women with schizophrenia: A 6-month, real-world chart review study","authors":"Bofan Chen ,&nbsp;Rulin Ma ,&nbsp;Shenhao Zhang ,&nbsp;Yun Liu","doi":"10.1016/j.schres.2025.06.009","DOIUrl":"10.1016/j.schres.2025.06.009","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"282 ","pages":"Pages 74-75"},"PeriodicalIF":3.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aberrant prefrontal-hippocampal connectivity of cross-modal associative memory impairment in schizophrenia","authors":"Zhaolin Zhai ,&nbsp;Tianhao Gao ,&nbsp;Haixin Cen ,&nbsp;Xuan Li ,&nbsp;Chang Lu ,&nbsp;Yuke Dong ,&nbsp;Kaiming Zhuo ,&nbsp;Yan Wang ,&nbsp;Chunhong Shao ,&nbsp;Qiong Xiang ,&nbsp;Dengtang Liu","doi":"10.1016/j.schres.2025.06.002","DOIUrl":"10.1016/j.schres.2025.06.002","url":null,"abstract":"<div><h3>Objective</h3><div>Associative memory (AM) impairment is considered as a core cognitive dysfunction and indicative of poor function in schizophrenia. Despite the robust findings of abnormalities in prefrontal-hippocampal network, yet the specific regions and definitive patterns have remained elusive. We adopted an innovative AM paradigm to disentangle the contributions of prefrontal-hippocampal network.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, 30 schizophrenia patients and 30 matched healthy controls (HCs) were recruited, scheduled for an MRI session on a 3.0T Siemens, and completed clinical evaluations. We performed seed-based functional connectivity (FC) analyses using the bilateral hippocampus (Hipp) as seeds and conducted Pearson's correlation analyses between FC and the AM performance.</div></div><div><h3>Results</h3><div>Compared to HCs, patients exhibited poorer AM functions in both same- and cross-domain conditions. Left Hipp exhibited decreased FC with clusters from medial and orbital superior frontal gyrus (SFG) bilaterally (p-FDR &lt; 0.001), while enhanced FC with clusters from bilateral inferior frontal gyrus (IFG), pars opercularis and triangularis (p-FDR &lt; 0.01) in the schizophrenia relative to HCs. Notably, decreased left Hipp-related FC was moderately positively correlated with cross-modal AM performance in HCs but not in the schizophrenia group. Conversely, a significant positive correlation was found between left Hipp-bilateral IFG FC values and cross-modal AM capacities in schizophrenia.</div></div><div><h3>Conclusions</h3><div>The current study demonstrated the disparities in AM deficits and substantiate correlative evidence for prefrontal-hippocampal network involvement in AM. These findings provide evidence for neuropathological mechanisms in schizophrenia, which potentially guiding relevant interventions and treatments.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"282 ","pages":"Pages 64-73"},"PeriodicalIF":3.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}