Schizophrenia Research最新文献

{"title":"Altered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity","authors":"Ava J.C. Mason ,&nbsp;William Palmer ,&nbsp;Hengyi Cao ,&nbsp;Jean Addington ,&nbsp;Carrie E. Bearden ,&nbsp;Kristin S. Cadenhead ,&nbsp;Barbara A. Cornblatt ,&nbsp;Diana O. Perkins ,&nbsp;Daniel H. Mathalon ,&nbsp;Elaine F. Walker ,&nbsp;Scott W. Woods ,&nbsp;Tyrone D. Cannon","doi":"10.1016/j.schres.2025.04.034","DOIUrl":"10.1016/j.schres.2025.04.034","url":null,"abstract":"<div><h3>Background</h3><div>Developmental trauma (DT) and poorer episodic memory performance are associated with increased risk of psychotic symptoms, but the mechanisms underlying these associations remain to be established. We sought to investigate whether memory performance and fMRI activity during the retrieval phase of an associative episodic memory task statistically mediated the relationship between trauma multiplicity and psychotic symptom severity in youth at clinical high risk for psychosis.</div></div><div><h3>Methods</h3><div>Measures from 795 participants in the North American Prodrome Longitudinal Study (phase two) were analysed. This included the Childhood Trauma and Abuse scale, neurocognitive measures, the Scale of Psychosis-Risk Symptoms and, in a subsample, neural activation from five regions of interest associated with memory processing (<em>n</em> = 219) during a paired-associate memory task (data from this task; <em>n</em> = 198). Linear regressions were conducted to measure whether trauma multiplicity predicted subclinical delusion and hallucination severity and neurocognitive performance, and neurocognitive measures predicted subclinical hallucination or delusion severity. We used mediation analysis when all paths were significant.</div></div><div><h3>Results</h3><div>Average functional activation in the five memory-associated regions mediated 8.74 % of the association between DT and subclinical hallucination severity, and 7.02 % between DT and delusion severity. Inferior parietal lobe activity mediated 10.08 % of the association between DT and subclinical hallucination severity, and 8.7 % between DT and subclinical delusion severity.</div></div><div><h3>Conclusions</h3><div>These findings suggest a role of episodic memory processing and inferior parietal lobe activation in the association between DT and psychosis. Focusing further on these measures could provide insight into the underlying mechanism of this association, and have clinical implications in trauma-exposed individuals with psychosis.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 115-121"},"PeriodicalIF":3.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained attenuation of sensorimotor network functional connectivity with acute and maintenance phase risperidone treatment in first-episode schizophrenia","authors":"Chithra Uppinkudru ,&nbsp;Neelabja Roy ,&nbsp;Rose Dawn Bharath ,&nbsp;Ganesan Venkatasubramanian ,&nbsp;Jagadisha Thirthalli ,&nbsp;Urvakhsh Meherwan Mehta","doi":"10.1016/j.schres.2025.04.037","DOIUrl":"10.1016/j.schres.2025.04.037","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 122-124"},"PeriodicalIF":3.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online racism and psychotic experiences among Black American and Asian/Native Hawaiian/Pacific Islander American emerging adults in the United States","authors":"Hans Y. Oh ,&nbsp;Brian Keum ,&nbsp;Erika Shults ,&nbsp;Summer Yang ,&nbsp;Deidre Anglin ,&nbsp;Oladunni Oluwoye ,&nbsp;Nicole R. Karcher","doi":"10.1016/j.schres.2025.04.036","DOIUrl":"10.1016/j.schres.2025.04.036","url":null,"abstract":"<div><h3>Background</h3><div>Racially and ethnically minoritized emerging adults in the United States have a higher prevalence of psychotic experiences when compared to their White peers. Racism gives rise to social stressors, including ethno-racial discrimination, which can increase the risk for psychotic experiences. Racism is ever-shapeshifting into new forms of racism, including online racism, yet little research has examined its associations with psychotic experiences.</div></div><div><h3>Methods</h3><div>We used Qualtrics panels to recruit emerging adults, including Black (N = 1200) and Asian American/Pacific Islander/Native Hawaiian (N = 1600). Using multivariable logistic regression, we examined the association between online racism (Online Racism Scale – Very Brief) and psychotic experiences (reporting at least one psychotic experience using the WHO CIDI psychosis screen), controlling for sociodemographic characteristics, everyday discrimination, internet usage, and mental health.</div></div><div><h3>Results</h3><div>Approximately 42 % of the sample reported a lifetime psychotic experience. In multivariable logistic regression models, a one-unit increase on the online racism scale was associated with a 13 % increase in odds of having a lifetime psychotic experience. This association attenuated slightly after adjusting for sociodemographic characteristics and further attenuated after adjusting for everyday discrimination, total internet usage, and depression and anxiety. After accounting for all covariates, a one-unit increase in online racism was associated with a 5 % increase in odds of psychotic experiences.</div></div><div><h3>Conclusion</h3><div>Online racism is more common than in-person discrimination, and people of color use social media platforms at high rates, where they inevitably face various types of online racism. Online racism is pervasive, often anonymous, and unmoderated, and these exposures are associated with greater odds of psychotic experiences.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 132-137"},"PeriodicalIF":3.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress sensitivity, negative affect, and functioning in an early psychosis clinic","authors":"Lindsay A. Bornheimer ,&nbsp;Adrienne Lapidos ,&nbsp;Molly Simmonite ,&nbsp;Takakuni Suzuki ,&nbsp;Ivy F. Tso ,&nbsp;Stephan F. Taylor","doi":"10.1016/j.schres.2025.05.001","DOIUrl":"10.1016/j.schres.2025.05.001","url":null,"abstract":"<div><div>Persons with psychotic disorders frequently exhibit stress sensitivity (SS), a low tolerance for everyday stresses, often manifesting as negative affect (NA), and frequently associated with poor functional outcome. To parse the relative contributions of SS and NA on functioning, we analyzed real-world data from consecutive evaluations in an early psychosis clinic, comparing a specific measure of stress sensitivity, the Psychological Stress Index, 9-item (PSI-9), with the Patient Health Questionnaire (PHQ-9), a measure of depressive NA, on the Work and Social Adjustment Scale (WSAS). A structural equation modeling framework tested the relationship between PSI-9, PHQ-9, and perceived functioning (WSAS), testing the hypothesis that the PSI-9 would predict functioning over and above the PHQ-9. The sample consisted of 103 patients, of whom 61 had a primary psychosis diagnosis. The PSI-9, PHQ-9 and WSAS scales were highly intercorrelated (r's 0.55–0.62). The primary model showed partial mediation of the relationship of PSI-9 with WSAS by PHQ-9 scores, as predicted. Follow-up models conducted separately for patients with and without a primary psychosis diagnoses showed that this relationship existed in both groups. Sex, entered as a co-variate in the models, did not affect the relationships. In exploratory models examining the effects of early childhood adversity, the Adverse Childhood Experiences scale, was positively related to PSI-9 scores, but only in the psychosis group. In conclusion, the PSI-9 measures SS, a phenotype important for subjective sense of functioning, over and above depressive symptoms rated on the PHQ-9, identifying a target for interventions addressing SS.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 125-131"},"PeriodicalIF":3.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing negative symptoms of schizophrenia in the context of remote independent ratings: a psychometric evaluation of BNSS and PANSS","authors":"Kazunori Tatsumi,&nbsp;Alexandra Parfitt,&nbsp;Lisa Weissfeld,&nbsp;Mark Opler","doi":"10.1016/j.schres.2025.04.032","DOIUrl":"10.1016/j.schres.2025.04.032","url":null,"abstract":"<div><div>Previous traditional psychometric validation studies have demonstrated that the Brief Negative Symptom Scale (BNSS) and the Positive and Negative Syndrome Scale (PANSS) have satisfactory psychometric properties in patients with schizophrenia. The objective of the current study is to expand this literature by evaluating the psychometric properties of both scales in a large, multicenter, multicultural, randomized control clinical trial in patients with schizophrenia with predominantly negative symptoms. The current study employs independent ratings, in which raters are blinded from the study protocol and administer both scales via videoconference. The BNSS demonstrated excellent internal consistency (Cronbach's alpha = 0.93). The results of discriminant and concurrent validity analyses supported the construct validity of the assessment. The exploratory factor analysis of the PANSS identified five distinct factors. Overall, BNSS and PANSS demonstrate good psychometric properties that are comparable to previous findings that were derived from traditional psychometric studies, typically conducted at a single site and utilizing face-to-face ratings. Our findings suggest that negative symptoms of schizophrenia can validly be measured using the BNSS and PANSS via remote methods.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 108-114"},"PeriodicalIF":3.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of mindfulness- and acceptance-based interventions for individuals with schizophrenia spectrum disorders: A systematic meta-review","authors":"Antonia Meinhart ,&nbsp;Annika Schmueser ,&nbsp;Steffen Moritz ,&nbsp;Kerem Böge","doi":"10.1016/j.schres.2025.03.040","DOIUrl":"10.1016/j.schres.2025.03.040","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Mindfulness- and acceptance-based interventions (MBIs/ABIs) for persons with schizophrenia spectrum disorders (SSD) aim to cultivate purposeful attention, mind-body awareness, and targeted action-taking. This systematic meta-review assessed the current body of evidence regarding the effects of MBIs/ABIs for SSD symptoms.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;The study was registered with PROSPERO (CRD42024535284) on June 3, 2024. Seven databases were searched between April 18 and April 19, 2024. Meta-analyses investigating the effects of MBIs/ABIs for SSD symptoms were considered. Two authors (AM, AS) independently completed data extraction and analysis. Evidence grading and methodology assessments were conducted using the Ioannidis' criteria, AMSTAR-2, and AMSTAR-Plus Content guidelines.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;A total of 18 meta-analyses with up to 2572 participants were considered; 14 studies were eligible for analysis. Results were classified according to Ioannidis' criteria; the effect size of the highest ranked study with the largest number of primary studies is presented. Percentages indicate the number of studies reporting significant results. Significant evidence was found at end of treatment for overall symptomatology (MBIs: 100 %, &lt;em&gt;n&lt;/em&gt; = 9, &lt;em&gt;g&lt;/em&gt; = −0·7 (total range: −0·417 to −1·152), 95% CI: [−1·052, −0·347], &lt;em&gt;I&lt;/em&gt;&lt;sup&gt;&lt;em&gt;2&lt;/em&gt;&lt;/sup&gt; = 95·36; ABIs: 25 %, &lt;em&gt;n&lt;/em&gt; = 29, &lt;em&gt;g&lt;/em&gt; = −1·065 (total range: −0·1 to −1·065) [−1·371, −0·759], &lt;em&gt;I&lt;/em&gt;&lt;sup&gt;&lt;em&gt;2&lt;/em&gt;&lt;/sup&gt; = 85·1), positive (MBIs: 50 %, &lt;em&gt;n&lt;/em&gt; = 6, &lt;em&gt;g&lt;/em&gt; = −0·296 (total range: −0·155 to −0·416) [−0·528, −0·064], &lt;em&gt;I&lt;/em&gt;&lt;sup&gt;&lt;em&gt;2&lt;/em&gt;&lt;/sup&gt; = 34·69; ABIs: 33·33 %, &lt;em&gt;n&lt;/em&gt; = 3, &lt;em&gt;g&lt;/em&gt; = −0·602 (total range: −0·602 to 0·147) [−1·014, −0·191], &lt;em&gt;I&lt;/em&gt;&lt;sup&gt;&lt;em&gt;2&lt;/em&gt;&lt;/sup&gt; = 0), negative (MBIs: 100 %, &lt;em&gt;n&lt;/em&gt; = 8, &lt;em&gt;g&lt;/em&gt; = −0·94 (total range: −0·384 to −0.98) [−1·466, −0·413], &lt;em&gt;I&lt;/em&gt;&lt;sup&gt;&lt;em&gt;2&lt;/em&gt;&lt;/sup&gt; = 86·42; ABIs: 25 %, &lt;em&gt;n&lt;/em&gt; = 2, &lt;em&gt;g&lt;/em&gt; = −0·631 (total range: −0·028 to −0.631) [−1·108, −1·154], &lt;em&gt;I&lt;/em&gt;&lt;sup&gt;&lt;em&gt;2&lt;/em&gt;&lt;/sup&gt; = 0), affective symptoms (MBIs: 50 %, &lt;em&gt;n&lt;/em&gt; = 9, &lt;em&gt;g&lt;/em&gt; = −0·971 (total range: −0·275 to −0·971) [−1·413, −0·529], &lt;em&gt;I&lt;/em&gt;&lt;sup&gt;&lt;em&gt;2&lt;/em&gt;&lt;/sup&gt; = 91·32; ABIs: 33·33 %, &lt;em&gt;n&lt;/em&gt; = 3, &lt;em&gt;g&lt;/em&gt; = −0·854 (total range: −0·472 to −0·854) [−1·255, −0·453, &lt;em&gt;I&lt;/em&gt;&lt;sup&gt;&lt;em&gt;2&lt;/em&gt;&lt;/sup&gt; = 0), social functioning (MBIs: 100 %, &lt;em&gt;n&lt;/em&gt; = 7, &lt;em&gt;g&lt;/em&gt; = −1·368 (total range: −0·452 to −1·368) [−2·194, −0·542], &lt;em&gt;I&lt;/em&gt;&lt;sup&gt;&lt;em&gt;2&lt;/em&gt;&lt;/sup&gt; = 94·3; ABIs: &lt;em&gt;g&lt;/em&gt; total range: −0·878 to 0·625), mindfulness (MBIs: 66·66 %, &lt;em&gt;n&lt;/em&gt; = 5, &lt;em&gt;g&lt;/em&gt; = −0·805 (total range: −0·488 to −1·429) [−1·16, −0·45], &lt;em&gt;I&lt;/em&gt;&lt;sup&gt;&lt;em&gt;2&lt;/em&gt;&lt;/sup&gt; = 0; ABIs: 66·66 %, &lt;em&gt;n&lt;/em&gt; = 1, &lt;em&gt;g&lt;/em&gt; = −0·959 (total range: −0·391 to −0·959) [−1·788, −0·129], &lt;em&gt;I&lt;/em&gt;&lt;sup&gt;&lt;em&gt;2&lt;/em&gt;&lt;/sup&gt; = NA), and acceptance (MBIs: &lt;em&gt;g&lt;/em&gt; total range: −0·381 to 0·38","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 91-107"},"PeriodicalIF":3.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosis associated with dementia: evaluation and management","authors":"Rajesh R. Tampi ,&nbsp;Pallavi Joshi ,&nbsp;Dilip V. Jeste","doi":"10.1016/j.schres.2025.04.022","DOIUrl":"10.1016/j.schres.2025.04.022","url":null,"abstract":"<div><div>Dementia is one of the most common neurodegenerative disorders in the world, and 34–63 % of individuals with dementia have psychotic symptoms. Neurobiological correlates of dementia with psychosis include significantly increased densities of senile plaques and neurofibrillary tangles and higher D3 receptor density. Limitations of proposed diagnostic criteria include a lack of specificity for psychotic symptoms in individuals with dementia, a lack of consistent differentiation between symptoms, late recognition, and not accounting for comorbid depression or agitation that may be the primary symptom, which makes diagnosis challenging. This review aims to provide clinicians, researchers, and policymakers with a comprehensive evaluation of psychosis in dementia, covering its epidemiology, neurobiology, diagnosis, and treatment strategies. We review both psychosocial and pharmacological interventions for dementia-related psychosis. Psychosocial treatments such as meaningful communication between persons with dementia and their caregivers, simplifying the living environment, and optimizing tasks can help reduce the adverse impact of psychosis. Evidence from meta-analyses indicates modest efficacy for cholinesterase inhibitors, antidepressants, and antipsychotics for psychosis in dementia. The use of antipsychotic medications is limited by increased risks for serious adverse effects including cerebrovascular events and death. Emerging therapies such as xanomeline-trospium present promising avenues for treatment. By synthesizing current evidence and clinical guidelines, this review provides a framework for improving diagnosis and treatment of psychosis in dementia, helping clinicians and researchers refine patient care strategies while informing future research directions.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 82-90"},"PeriodicalIF":3.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue highlights","authors":"","doi":"10.1016/S0920-9964(25)00170-7","DOIUrl":"10.1016/S0920-9964(25)00170-7","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Page A1"},"PeriodicalIF":3.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood-level social determinants of suicidality in youth with schizophrenia: An EHR-based study","authors":"Jeonghyun Shin ,&nbsp;Jialin Wu ,&nbsp;Hyun Jung Kim ,&nbsp;Wenna Xi","doi":"10.1016/j.schres.2025.04.035","DOIUrl":"10.1016/j.schres.2025.04.035","url":null,"abstract":"<div><h3>Background</h3><div>Suicidal thoughts and behaviors (STB) among youth with schizophrenia represent a significant public health concern. It is well-established that neighborhood-level social determinants of health (SDoHs) can impact health outcomes in individuals with schizophrenia. We aimed to investigate the effects of neighborhood-level social determinants on developing future STB in youth with schizophrenia.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study using electronic health records from the INSIGHT Clinical Research Network, which contains &gt;22 million unique patients across five healthcare systems in New York City. Patients' neighborhood-level SDoHs were measured at their residential ZIP Code Tabulation Area using a composite measure, Social Deprivation Index (SDI), as well as specific components derived from the American Community Survey. Survival analysis was used to study the association between neighborhood-level SDoHs and time to STB since the first schizophrenia diagnosis.</div></div><div><h3>Results</h3><div>Between 10/1/2015 and 10/1/2022, we identified 1209 youth aged between 10 and 25 years with a schizophrenia diagnosis and no prior STB, among whom 176 developed STB during follow-up. SDI quintiles were not associated with the risk of future STB, whereas two specific neighborhood characteristics, Gini index and percentage of residents commuting by car/truck/van, were associated with a decreased risk of STB, after controlling for patients' demographic characteristics.</div></div><div><h3>Conclusions</h3><div>Although the overall neighborhood deprivation level was not associated with the risk of STB among youth with schizophrenia, specific neighborhood characteristics were. These findings underscore the need for more targeted community-based suicide prevention strategies. Further research is essential to better understand the underlying mechanism of these associations.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 74-81"},"PeriodicalIF":3.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediterranean and standard American diet consumption in psychosis and non-psychosis affective disorders groups: Symptoms and cognition","authors":"Lauren R. Koralnik ,&nbsp;Ezequiel Lafont ,&nbsp;Christa Akerele ,&nbsp;Mharisi Bonner ,&nbsp;Audrey Musselman ,&nbsp;Eugene Ruby ,&nbsp;Oded Gonen ,&nbsp;Eyal Lotan ,&nbsp;Jakleen Lee ,&nbsp;Jose C. Clemente ,&nbsp;Jessica Robinson-Papp ,&nbsp;Judith Weissman ,&nbsp;Julie Walsh-Messinger ,&nbsp;Dolores Malaspina","doi":"10.1016/j.schres.2025.04.025","DOIUrl":"10.1016/j.schres.2025.04.025","url":null,"abstract":"<div><div>Research supports an association between diet and health, and emerging evidence suggests that diet is associated with neuropsychiatric symptoms. However, no human study has examined an anti-inflammatory diet across rigorously defined psychiatric diagnoses and its associations with symptom severity and cognition. As inflammation is implicated in mental illness, we investigated adherence to the Mediterranean diet (MD), an anti-inflammatory diet, and the standard American diet (SAD), and examined cross-sectional relationships with psychiatric symptoms and cognition. Method: Participants included 54 individuals with psychotic disorders, 30 with non-psychosis affective disorders and 40 healthy controls. Participants underwent diagnostic interviews, PANSS symptom ratings, and MATRICS cognitive assessments. The self-report GBAQ was used to assess adherence to the MD versus SAD. Results: The psychosis group was significantly more likely to consume the SAD than healthy controls (p = 0.007), with MD adherence predicting better working memory (r = 0.461, p &lt; 0.001). In the non-psychosis affective disorders group, MD adherence predicted slower processing speed (r = -0.376, p = 0.049). In the non-psychosis affective disorders group, MD predicted reduced PANSS General Psychopathology scale (r = -0.449, p = 0.013), as well as the Activation (r = -0.362, p = 0.049), and Dysphoric Mood factors (r = -0.403, p = 0.027).Discussion: This first-of-its kind study identified poor dietary choices in persons with psychosis, showing significantly lower symptoms and better cognition in association with the MD in transdiagnostic analyses. It supports the study of dietary interventions for prevention and treatment of psychiatric conditions.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 60-73"},"PeriodicalIF":3.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}