Schizophrenia Research最新文献

Schizophrenia and antipsychotic medications present distinct and shared gut microbial composition: A meta-analysis. 精神分裂症和抗精神病药物的肠道微生物组成既有区别又有共性：荟萃分析

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-10-09 DOI: 10.1016/j.schres.2024.07.053

Weirong Cheng, Mengjie Zhao, Xinyun Zhang, Xia Zhou, Jun Yan, Rui Li, Hong Shen

{"title":"Schizophrenia and antipsychotic medications present distinct and shared gut microbial composition: A meta-analysis.","authors":"Weirong Cheng, Mengjie Zhao, Xinyun Zhang, Xia Zhou, Jun Yan, Rui Li, Hong Shen","doi":"10.1016/j.schres.2024.07.053","DOIUrl":"https://doi.org/10.1016/j.schres.2024.07.053","url":null,"abstract":"<p><p>There are some conflicting results regarding alterations of gut microbial composition in schizophrenia (SZ), even a few meta-analysis studies have addressed this field. Ignoring of antipsychotic medication effects may cause the large heterogeneity and impact on study results. This study is a meta-analysis to systematically evaluate composition of gut microbiota in patients with SZ, to elucidate the impact of antipsychotic use and reveal distinct and shared gut bacteria in SZ and antipsychotic medications. We re-analyzed the publicly available 16S rRNA-gene amplicon datasets by a standardized pipeline in QIIME2, used the natural log of response ratios as an effect index to directly and quantitatively compare composition of gut microbiota by random-effects meta-analysis with resampling tests in Metawin, ultimately to evaluate distinct abundance of gut bacteria. A total of 19 studies with 1968 participants (1067 patients with SZ and 901 healthy controls (HCs)) were included in this meta-analysis. The alterations of alpha diversity indices occurred in SZ on antipsychotics but not in drug-naïve or -free patients, while variation of beta diversity metrics appeared in SZ regardless of antipsychotic use. After antipsychotic treatment, reversed Simpson index, decreased observed species index and significant difference of Bray-Curtis distance were observed in patients. Especially, risperidone treatment increased the Shannon and Simpson indices. Noteworthy, three differed genera, including Lactobacillus, Roseburia and Dialister, were identified in both states of antipsychotic use. This meta-analysis is to provide a novel insight that SZ and antipsychotic medications present distinct and shared gut microbial composition.</p>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of CACNA1C polymorphisms (rs1006737, rs4765905, rs2007044) with schizophrenia: A meta-analysis and trial sequential analysis. CACNA1C多态性（rs1006737、rs4765905、rs2007044）与精神分裂症的关系：荟萃分析和试验序列分析。

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-10-07 DOI: 10.1016/j.schres.2024.09.029

Surjyapratap Sarangi, Saurav Sharma, Suraj Kumar Nahak, Aditya K Panda

{"title":"Association of CACNA1C polymorphisms (rs1006737, rs4765905, rs2007044) with schizophrenia: A meta-analysis and trial sequential analysis.","authors":"Surjyapratap Sarangi, Saurav Sharma, Suraj Kumar Nahak, Aditya K Panda","doi":"10.1016/j.schres.2024.09.029","DOIUrl":"https://doi.org/10.1016/j.schres.2024.09.029","url":null,"abstract":"<p><p>Schizophrenia is a complex neurological disorder characterized by significant impairment in the perception of reality and changes in behavior. Genetic and environmental factors influence the development of schizophrenia. CACNA1C, which encodes a subunit of a voltage-dependent calcium channel, has been associated with various neurological disorders, including schizophrenia. Several studies have been performed in different populations to explore the association of common genetic variants in the CACNA1C gene with susceptibility to the development of schizophrenia, but results remain contradictory. To draw a definitive conclusion on the association between CACNA1C polymorphisms and schizophrenia, we conducted a meta-analysis focusing on three commonly studied polymorphisms: rs1006737, rs4765905, and rs2007044. For the meta-analysis, a comprehensive literature search was performed using PubMed, Scopus, Science Direct and Google Scholar databases. Data was retrieved, and the meta-analysis was performed using CMA v4 software. The meta-analysis revealed a significant association between rs1006737 and rs2007044 and schizophrenia in the overall population, while no such association was found for rs4765905. Population-wise analysis suggested that all three polymorphisms were significantly associated with schizophrenia in the Asian population and that rs1006737 was significantly associated with schizophrenia in Europeans. We also performed a Trial Sequential Analysis (TSA), which supported our findings. Some report-based assay studies have suggested a role for these polymorphisms in schizophrenia, but further case-control studies are needed to confirm the association of rs4765905 and rs2007044 with the disorder.</p>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dyadic interaction in schizophrenia - A promising new avenue of investigation? 精神分裂症中的二元交互作用--有希望的新研究途径？

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-10-03 DOI: 10.1016/j.schres.2024.09.032

Michal Hajdúk, Sohee Park, Amy E Pinkham

引用次数: 0

Aligning phenomenology and neuroscience of the basic and narrative self in schizophrenia. 将精神分裂症患者的基本自我和叙事自我的现象学与神经科学结合起来。

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-10-03 DOI: 10.1016/j.schres.2024.09.033

Henry R Cowan

引用次数: 0

Early and later remission from clinical high risk of psychosis. A latent class and predictor analysis 临床高危精神病的早期和后期缓解。潜类和预测因子分析

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-10-01 DOI: 10.1016/j.schres.2024.09.024

{"title":"Early and later remission from clinical high risk of psychosis. A latent class and predictor analysis","authors":"","doi":"10.1016/j.schres.2024.09.024","DOIUrl":"10.1016/j.schres.2024.09.024","url":null,"abstract":"<div><h3>Background</h3><div>In high-risk for psychosis (CHR-P) much focus has been on the transition to psychosis. However, the desired outcome remains symptomatic remission and improved functioning as early as possible. This study aims to investigate predictors of sub-groups of remission and functional outcomes.</div></div><div><h3>Material and methods</h3><div>A two-year prospective follow-up study of 104 CHR-P participants recruited in Norway using systematic early detection strategies. The Structural Interview for Prodromal Syndromes (SIPS) was used to assess CHR-P. Participants were classified as remitted or non-remitted based on their symptom scores. A latent class analysis was performed on the dichotomous data to identify latent classes regarding the timing of remission. <em>t</em>-tests and chi-squared tests were used to assess the association between class affiliations, predictors and outcomes.</div></div><div><h3>Results</h3><div>The latent class analysis showed moderate fit and divided the participants into three remission classes: “poor chance of remission” (16.7 %), “later remission” (34.3 %), and “early remission” (49.0 %). The “early remission” class had the highest probability of fast and stable remission, and had better premorbid academic, and baseline and 2-year global functioning than the “later remission” class. Baseline predictors such as age, SIPS symptoms, drug use, years in school and gender were not significantly associated with remission class.</div></div><div><h3>Discussion</h3><div>The study's main finding is the division of CHR-P remission into “early remission” and “later remission” and predictors of class affiliation. The monthly follow-up during the first six months allowed for the detection of this division. The findings suggest the importance of considering functioning in models of remission from CHR-P.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of acute smoking abstinence among people with schizophrenia: A systematic review and meta-analysis of laboratory studies 精神分裂症患者急性戒烟的效果：实验室研究的系统回顾和荟萃分析

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-09-30 DOI: 10.1016/j.schres.2024.09.025

{"title":"Effects of acute smoking abstinence among people with schizophrenia: A systematic review and meta-analysis of laboratory studies","authors":"","doi":"10.1016/j.schres.2024.09.025","DOIUrl":"10.1016/j.schres.2024.09.025","url":null,"abstract":"<div><h3>Background</h3><div>Smoking rates in schizophrenia are exceptionally high; however, cessation rates remain low with limited research on effective interventions. A critical component of intervention development is identifying the effects of abstinence that are most salient and therefore may contribute to lapse and relapse.</div></div><div><h3>Objectives</h3><div>We conducted a systematic review and meta-analysis of controlled laboratory studies investigating acute smoking abstinence effects among people with schizophrenia and schizoaffective disorder.</div></div><div><h3>Methods</h3><div>This review is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. OVID (MEDLINE, EMBASE, PsycINFO) and PubMed databases were searched from inception until November 2023.</div></div><div><h3>Results</h3><div>We identified (k = 16) articles meeting inclusion criteria; all assessed smoking abstinence (ranging 2–120 h). Acute abstinence resulted in large increases in reward-oriented craving and moderate increases in relief-oriented craving; these effects were greater in studies with longer abstinence duration (high certainty). We also observed significant increases in negative affect and global withdrawal symptoms, as well as memory disruption (moderate certainty). Qualitative synthesis suggests restlessness, irritability, anxiety, and visuospatial working memory may be additionally impacted. Findings with respect to negative symptoms and movement were mixed.</div></div><div><h3>Conclusions</h3><div>Reward-oriented craving may constitute a key target of smoking cessation interventions for people with schizophrenia. In addition, identification of pharmacological and psychosocial interventions that address abstinence-induced changes in relief-oriented craving, memory, negative affect, restlessness, irritability, and anxiety may strengthen treatment outcomes.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A network meta-analysis of KarXT and commonly used pharmacological interventions for schizophrenia 对 KarXT 和常用药物干预精神分裂症的网络荟萃分析。

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-09-29 DOI: 10.1016/j.schres.2024.09.023

{"title":"A network meta-analysis of KarXT and commonly used pharmacological interventions for schizophrenia","authors":"","doi":"10.1016/j.schres.2024.09.023","DOIUrl":"10.1016/j.schres.2024.09.023","url":null,"abstract":"<div><h3>Background</h3><div>Dopaminergic antipsychotics for schizophrenia have modest effects on symptoms and can cause important side effects. KarXT is an investigational drug for schizophrenia with a novel mechanism targeting muscarinic receptors that may limit these side effects.</div></div><div><h3>Methods</h3><div>We conducted a systematic review and Bayesian random-effects network meta-analyses of short-term RCTs (3–8 weeks) that enrolled adults with schizophrenia. We compared KarXT to aripiprazole, risperidone, and olanzapine. We sought evidence for symptoms (Positive and Negative Symptoms Scale [PANSS]), weight gain, and all-cause discontinuation.</div></div><div><h3>Results</h3><div>We included 33 trials with 7193 participants. For total, positive, and negative symptoms, KarXT and the three antipsychotics were significantly more efficacious than placebo (mean difference [MD] vs placebo range for total symptoms: −10.67 to −8.05; positive symptoms: −3.46 to −2.53; negative symptoms: −1.99 to −1.44) but not significantly different from each other. KarXT was ranked as least likely to lead to weight gain. This was significant versus risperidone (−2.06 kg; 95 % CrI: −3.28, −0.87) and olanzapine (−2.86 kg; 95 % CrI: −3.97, −1.82). However, KarXT was ranked highest for all-cause discontinuation. This was significant versus risperidone (RR: 0.64; 95 % CrI: 0.46, 0.89) and olanzapine (RR: 0.6; 95 % CrI: 0.44, 0.83).</div></div><div><h3>Conclusions</h3><div>KarXT and commonly used antipsychotics were more efficacious than placebo at reducing symptoms, but there were no clear differences in short-term efficacy among the active interventions. KarXT was less likely to cause weight gain, an important outcome for those with schizophrenia; short-term data do not permit evaluation of the risk for tardive dyskinesia. Long-term data are needed.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Schizophrenia spectrum disorders in children and adolescents: Clinical, phenomenological, diagnostic, and prognostic features across subtypes 儿童和青少年精神分裂症谱系障碍：各亚型的临床、现象学、诊断和预后特征

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-09-27 DOI: 10.1016/j.schres.2024.09.019

{"title":"Schizophrenia spectrum disorders in children and adolescents: Clinical, phenomenological, diagnostic, and prognostic features across subtypes","authors":"","doi":"10.1016/j.schres.2024.09.019","DOIUrl":"10.1016/j.schres.2024.09.019","url":null,"abstract":"<div><div>Schizophrenia spectrum disorders (SSD) typically have a diagnostically recognizable onset in young adulthood, yet it is not unusual that help-seeking due to initial SSD-related clinical manifestations emerge in earlier developmental phases, such as childhood and adolescence. Varieties of SSD manifestations in children and adolescents can be distinguished according to variations in clinical expressivity, severity and timing (i.e. developmental stage). Some individuals may reach the full clinical threshold for a diagnosis of schizophrenia according to the same descriptive diagnostic criteria used for adults, and in this case, it's possible to distinguish a pre-pubertal onset in childhood (aka Very Early Onset Schizophrenia, VEOS) and a post-pubertal onset in adolescence (aka Early Onset Schizophrenia, EOS). Other individuals may not reach such clinically overt diagnostic threshold but nonetheless present Childhood Schizotypal Disorder (CSD) or a Clinical High-Risk for Psychosis (CHR<img>P). While EOS is clinically more similar to the canonical adult-onset presentation, the other 3 subgroups (i.e. VEOS, CSD, CHR<img>P) present more nuances and specific clinical characteristics, which require ad-hoc developmental and phenomenological considerations for appropriate differential diagnosis and prognosis. Therefore, current scoping review intends to saturate such knowledge gap with respect to early SSD-phenotypes.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142324115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Winter birth: A factor of poor functional outcome in a Swiss early psychosis cohort 冬季出生：瑞士早期精神病队列中功能不良的一个因素

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-09-27 DOI: 10.1016/j.schres.2024.09.022

{"title":"Winter birth: A factor of poor functional outcome in a Swiss early psychosis cohort","authors":"","doi":"10.1016/j.schres.2024.09.022","DOIUrl":"10.1016/j.schres.2024.09.022","url":null,"abstract":"<div><h3>Objective</h3><div>Winter birth has consistently been identified as a risk factor for schizophrenia. This study aimed to determine whether individuals born during this season are also at higher risk for early psychosis and whether this is associated with distinct functional and clinical outcomes.</div></div><div><h3>Methods</h3><div>We conducted a prospective study on 222 patients during their early phase of psychosis in Switzerland, nested in the Treatment and Early Intervention in Psychosis (TIPP) cohort. We compared the birth trimesters of these patients with those of the general Swiss population. Additionally, we evaluated the Global Assessment of Functioning scale (GAF) and the Positive and Negative Syndrome Scale (PANSS) scores among patients born in winter (January to March) versus those born during the rest of the year during a three-year follow-up period.</div></div><div><h3>Results</h3><div>A significantly higher proportion of patients experiencing early psychosis were born in winter compared to the general Swiss population. Patients born in winter had significantly lower GAF scores at 6 months, 24 months, and 36 months of follow-up, compared to patients born during the rest of the year. They also manifested fewer positive symptoms, as indicated by the PANSS positive subscale.</div></div><div><h3>Conclusion</h3><div>Birth in winter appears to be associated with a lower functional outcome and potentially distinct symptomatology in the early phase of psychosis.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep quality, psychological resilience, family resilience, social support, and mental disability in patients with chronic schizophrenia: A cross-sectional study 慢性精神分裂症患者的睡眠质量、心理复原力、家庭复原力、社会支持和精神残疾：横断面研究

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-09-27 DOI: 10.1016/j.schres.2024.09.020

{"title":"Sleep quality, psychological resilience, family resilience, social support, and mental disability in patients with chronic schizophrenia: A cross-sectional study","authors":"","doi":"10.1016/j.schres.2024.09.020","DOIUrl":"10.1016/j.schres.2024.09.020","url":null,"abstract":"<div><div>After the remission of psychotic symptoms in patients with chronic schizophrenia, a persistently high rate of disability suggests potential influences from socio-ecological factors. This study aimed to explore the complex relationships between socioecological factors, including sleep quality, psychological resilience, family resilience, and social support, and the severity of psychiatric disability in patients with chronic schizophrenia. Employing a cross-sectional design, the study involved 188 individuals with chronic schizophrenia. Disability was measured using the World Health Organization Disability Assessment Schedule 2.0 (WHO-DAS 2.0), while social support, family resilience, psychological resilience, and sleep quality were assessed using the Social Support Rating Scale (SSRS), Family Hardiness Index (FHI), Connor-Davidson Resilience Scale (CD-RISC), and Pittsburgh Sleep Quality Index (PSQI), respectively. LASSO regression and structural equation modeling (SEM) analyses were conducted to identify predictive factors and their interrelationships. The mean WHO-DAS 2.0 score of 72.91 ± 14.04 indicated substantial difficulties in daily activities, necessitating comprehensive support among participants. LASSO regression identified frequent disease relapses, low education levels, and poor sleep quality as risk factors for disability, whereas strong social support, family resilience, and individual resilience emerged as protective factors against disability. SEM demonstrated that the enhancement of family and individual resilience by social support contributes to the mitigation of disability. The study underscores the critical roles of social support, family resilience, and individual psychological resilience in reducing disability in patients with chronic schizophrenia, suggesting that interventions targeting these factors may improve rehabilitation outcomes.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0