Schizophrenia Research最新文献

{"title":"Corrigendum to \"Positive symptoms and medication adherence in response to oral versus long-acting injectable risperidone in black, latino, and white first-episode psychosis patients\" [Schizophr Res. (2025) 160-166].","authors":"Derek M Novacek, Kenneth L Subotnik, Joseph Ventura, Laurie R Casaus, Fiona Whelan, Catherine A Sugar, Keith H Nuechterlein","doi":"10.1016/j.schres.2025.09.026","DOIUrl":"10.1016/j.schres.2025.09.026","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapy process factors in early psychosis: The effect of working alliance on clinical symptoms and cognitive biases in Ultra High Risk young people.","authors":"Paulina Bagrowska, Cassandra Wannan, Andrea Polari, Hok Pan Yuen, Paul Amminger, Melissa Kerr, Jessica Spark, Nicky Wallis, Martha Shumway, Cameron Carter, Lisa Dixon, Tara A Niendam, Rachel Loewy, Patrick McGorry, Barnaby Nelson","doi":"10.1016/j.schres.2025.07.031","DOIUrl":"10.1016/j.schres.2025.07.031","url":null,"abstract":"<p><p>Approximately 25 % of individuals at Ultra High Risk (UHR) transition to a full psychotic disorder. Cognitive biases are thought to play a role in this risk, and improvements in cognitive biases have been associated with better clinical outcomes. Early intervention is crucial, yet no therapeutic approach has proven superior, and treatment adherence remains a challenge. Therapeutic alliance, shown to enhance adherence and clinical outcomes, might also influence depression and cognitive biases, but its role in these domains among UHR patients remains unclear. A total of 202 UHR participants (59.4 % females, mean age 17.4), taking part in the sequential multiple-assignment randomized trial (SMART), completed questionnaires assessing cognitive biases, attenuated psychotic symptoms, quality of life, general and social functioning, depression, and overall psychopathology at baseline, and at 6- and 12-month follow-ups. Additionally, both patients and their corresponding therapists rated working alliance following the 6- and 12-month treatment periods. The results revealed that patient-rated therapeutic alliance significantly predicted improvements in attenuated psychotic symptoms, cognitive biases, general psychopathology, social functioning, and quality of life, with the strongest effects observed when measured 6 months into treatment. The relationship between working alliance and decreases in attenuated psychotic symptoms, as well as between working alliance and reduction in general psychopathology, turned out to be mediated by improvements in cognitive biases. Therapist-rated working alliance did not significantly predict clinical improvements, showing only a minor association with quality of life. Strengthening the therapeutic alliance and prioritizing cognitive bias modification early in interventions for UHR patients may improve treatment outcomes. Further research is needed to validate these findings.</p>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"284 ","pages":"151-159"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive symptoms and medication adherence in response to oral versus long-acting injectable risperidone in black, latino, and white first-episode psychosis patients.","authors":"Derek M Novacek, Kenneth L Subotnik, Joseph Ventura, Laurie R Casaus, Fiona Whelan, Catherine A Sugar, Keith H Nuechterlein","doi":"10.1016/j.schres.2025.08.004","DOIUrl":"10.1016/j.schres.2025.08.004","url":null,"abstract":"<p><p>Black and Latino Americans are more likely to be diagnosed with psychotic disorders compared to White Americans. Furthermore, there are well documented ethnoracial disparities in access to second-generation antipsychotics including long-acting injectables (LAIs). LAI medications have the potential to help attenuate disparities by improving adherence and thus reducing relapse. Given this knowledge, a more concerted effort is needed to examine the clinical response and adherence to these medications in the early stages of psychosis. The present study examined positive symptoms and medication adherence in response to oral versus LAI risperidone in a sample of Black (N = 24), Latino (N = 34), and White (N = 17) first-episode psychosis patients. Participants were recruited from local psychiatric hospitals and enrolled in a randomized controlled trial. Participants were randomly assigned to receive oral or LAI risperidone. Findings suggest that Latino patients were less likely to benefit from LAI risperidone and also had higher rates of nonadherence across medication conditions. Both Black and White patients benefited from LAI in terms of positive symptoms and medication adherence. Future studies should examine sociocultural factors that could be influencing the acceptability of LAIs for Latino first-episode patients as well as develop culturally responsive interventions to improve medication adherence and clinical outcomes. In addition, greater advocacy and equitable policies are likely needed to ensure access to LAIs for minoritized populations.</p>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"284 ","pages":"160-166"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychotic-like experiences and working memory connectivity in adolescents and young adults: A study on Turkish twins.","authors":"Didenur Şahin-Çevik, Serenay Çakar, Fulya Gökalp Yavuz, Seda Arslan, Hao Yang Tan, Muhammad A Parvaz, Timothea Toulopoulou","doi":"10.1016/j.schres.2025.07.029","DOIUrl":"10.1016/j.schres.2025.07.029","url":null,"abstract":"<p><strong>Objective: </strong>Psychotic-like experiences (PLEs) are common during adolescence, with distress playing a key role in their clinical significance. Working memory (WM) deficit is an endophenotype for psychosis that may also be present in individuals with PLEs. The neural mechanisms underlying PLEs remain underexplored, particularly in non-western non-European populations. We hypothesized that altered frontal connectivity during a WM fMRI paradigm would be associated with PLEs and that twin modeling would reveal both genetic and environmental factors as contributing to these traits.</p><p><strong>Methods: </strong>474 Turkish adolescent and young adult twins and siblings (aged 14-23) underwent fMRI, clinical, and additional evaluations. Seed-based connectivity analysis was conducted using 11 predefined prefrontal regions, given their role in WM and psychosis, during the manipulation condition. These connectivity variables were then used as predictors in linear mixed models of PLE frequency and distress. Additionally, twin modeling was conducted to quantify the genetic and environmental contributions to these traits.</p><p><strong>Results: </strong>Altered connectivity in the inferior frontal gyrus was associated with increased frequency and distress of PLEs. Twin models revealed moderate heritability for PLE distress, whereas PLE frequency and WM connectivity during fMRI showed environmental influences. Bivariate twin models suggested no significant genetic or environmental covariance between PLEs and frontal connectivity.</p><p><strong>Conclusion: </strong>Our findings emphasize the importance of distinguishing between the distress and frequency of PLEs, as they may have different underlying influences. These results highlight the role of environmental exposures in shaping PLEs and frontal connectivity during adolescence, paralleling findings on schizophrenia.</p>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"284 ","pages":"167-174"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical health among persons with untreated psychotic disorder in diverse settings of the Global South.","authors":"Akin Ojagbemi, Olufemi Idowu, Bola Olley, Georgina Miguel Esponda, Tessa Roberts, Sujit John, Vijaya Raghavan, Joni Lee Pow, Casswina Donald, Olatunde Ayinde, Joseph Lam, Paola Dazzan, Fiona Gaughran, Alex Cohen, Helen A Weiss, Robin M Murray, Rangaswamy Thara, Gerard Hutchinson, Craig Morgan, Oye Gureje","doi":"10.1016/j.schres.2025.07.027","DOIUrl":"10.1016/j.schres.2025.07.027","url":null,"abstract":"<p><strong>Background: </strong>There is limited information on the prevalence and profile of comorbid physical health conditions in persons with untreated psychotic disorder in countries of the Global South.</p><p><strong>Aim: </strong>To investigate the frequency of occurence and association of physical health indicators with untreated psychotic disorder in three diverse settings in the Global South.</p><p><strong>Methods: </strong>Data were collected as part of the International Research Programme on Psychoses in Diverse Settings (INTREPID II), a population-based incidence and case-control study conducted in selected catchment areas in India, Nigeria, and Trinidad. Cases were aged 18-64 years with an untreated psychotic disorder diagnosed according to ICD 10 criteria. Control participants were matched for age, sex, and neighbourhood. Physical health measurements were acquired using the WHO STEPwise approach to non-communicable disease risk factors surveillance instrument (WHO STEPS). We estimated adjusted odds ratios (aOR) using unconditional logistic regression.</p><p><strong>Results: </strong>We included 225, 209, and 212 case-control pairs, respectively in Kancheepuram (India), Ibadan (Nigeria), and Northern Trinidad. Among cases, we found marked variations in health behaviours and physical health indicators across settings. In case-control comparisons within settings, cases were more likely to report poor diet (aORs of 1.31 [Trinidad] to 3.70 [Ibadan]), current smoking (aORs of 2.21 [Kancheepuram] to 3.35 [Trinidad]), and physical inactivity (aORs of 0.23 [Ibadan] to 0.62 [Kancheepuram]). However, we found no strong evidence that indicators of cardiometabolic comorbidity were consistently more common among cases compared with controls (i.e.,cases across sites were less likely than controls to have high blood pressure (aORs of 0.65 [Ibadan] to 0.76 [Trinidad]) and to be overweight (aORs of 0.70 [Kancheepuram] and 0.85 [Trinidad]), but were more likely than controls to have diabetes (aOR 1.94) and raised C-reactive protein levels (aOR 2.31) in Ibadan. By contrast, cases were more likely than controls to be underweight in all sites (aORs of 1.76 [Trinidad] to 3.67 [Ibadan]). In Kencheepuram (aOR 1.60) and Ibadan (aOR 2.66), cases were more likely to have a positive blood test for infection. These findings were broadly similar after accounting for health behaviours.</p><p><strong>Conclusion: </strong>In three settings in the Global South, persons with untreated psychotic disorder were more likely to report poorer health behaviours, to be underweight, and experience more infections, possibly reflecting severe economic and social disadvantage in the settings of this study.</p>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"284 ","pages":"141-150"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining psychological protective mechanisms as moderators of the association between autistic traits and psychosis expression in a general population twin sample.","authors":"Melike Karaçam Doğan, Laura Fusar-Poli, Angelo Arias-Magnasco, Lotta-Katrin Pries, Bochao Danae Lin, Boris Klingenberg, Riccardo Bortoletto, Marco Colizzi, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Nele Jacobs, Jim van Os, Bart Rutten, Jurjen Luykx, Thanavadee Prachason, Sinan Guloksuz","doi":"10.1016/j.schres.2025.08.003","DOIUrl":"10.1016/j.schres.2025.08.003","url":null,"abstract":"<p><strong>Background: </strong>Psychological protective factors, such as coping styles, extraversion, and optimal parenting, may reduce the risk of psychosis. However, their role in moderating the association between autistic traits (ATs) and psychosis expression (PE) remains understudied.</p><p><strong>Methods: </strong>This study analyzed the first-wave data from the TwinssCan Project (n = 792 twins and siblings, 60.2 % female, mean age = 17.4 ± 3.6). ATs and PE were assessed using the Autism-Spectrum Quotient and the Community Assessment of Psychic Experiences (CAPE), respectively. Multilevel linear regression models were used to evaluate the moderating effects of seven coping styles (active coping, avoidance, reassuring thoughts, expressing emotions, seeking social support, palliative-reacting, and passive-reacting coping), extraversion, and optimal parenting.</p><p><strong>Results: </strong>Seeking social support (B[95 %CI]:-0.005[-0.009,-0.001]), reassuring thoughts (B[95 %CI]:-0.005[-0.009,-0.001]), extraversion (B[95 %CI]: -0.03[-0.04,-0.01]) and optimal parenting (B[95 %CI]: -0.02[-0.03,0]) weakened the associations between ATs and CAPE total frequency scores, suggestive of protective mechanisms, whereas passive-reacting coping (B[95 %CI]:0.007[0.004,0.010]) strengthened this, suggestive of a risk factor. Additionally, avoidance(B[95 %CI]:0.09[0.02,0.16]) emerged as a risk factor in confirmatory analyses by significantly interacting with ATs in predicting CAPE total severity scores.</p><p><strong>Conclusions: </strong>Engagement coping, extraversion, and optimal parenting may mitigate psychosis vulnerability in individuals with higher ATs, while passive-reactive coping and avoidance may heighten psychosis vulnerability. Although further research is needed, our findings provide a rationale for developing and testing targeted preventive strategies aimed at enhancing resilience in individuals with ATs.</p>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"284 ","pages":"133-140"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-month antipsychotic exposure induces domain-specific eye movement alterations in clinical high-risk individuals","authors":"Aimei Ye ,&nbsp;Dan Zhang ,&nbsp;Xu Liu ,&nbsp;Lihua Xu ,&nbsp;Yanyan Wei ,&nbsp;Huiru Cui ,&nbsp;Wensi Zheng ,&nbsp;Yawen Hong ,&nbsp;Jinyang Zhao ,&nbsp;Yingying Tang ,&nbsp;Min Su ,&nbsp;Yong Ye ,&nbsp;Yingli Huang ,&nbsp;Tianhong Zhang ,&nbsp;Jijun Wang","doi":"10.1016/j.schres.2025.09.024","DOIUrl":"10.1016/j.schres.2025.09.024","url":null,"abstract":"<div><h3>Background</h3><div>While antipsychotic-induced eye movement alterations are well-documented in schizophrenia, their effects during the clinical high-risk (CHR) phase remain uncharacterized. This study examined the effects of two-month antipsychotic treatment on eye movement parameters in CHR individuals and their association with clinical outcome.</div></div><div><h3>Methods</h3><div>In this longitudinal cohort, 139 CHR individuals and 105 healthy controls completed baseline eye-tracking (fixation stability, free viewing, and smooth pursuit). CHR participants were reassessed at two months and followed for three years to track remission status. Linear mixed-effects models examined the effects of antipsychotic use, dose, and type on eye movement indicators, and a random forest model evaluated how changes in these indicators predicted clinical remission.</div></div><div><h3>Results</h3><div>In the antipsychotic - treated subgroup, fixation stability featured more microsaccades, free viewing showed reduced saccade amplitude and velocity, and smooth pursuit showed increased velocity gain with reduced saccade amplitude, and these changes scaled with dose and varied by agent with the most pronounced effects for aripiprazole. A random forest classifier using two treatment-induced eye movement change values predicted 3-year clinical non-remission with an area under the receiver operating characteristic curve of 0.80.</div></div><div><h3>Conclusions</h3><div>Short-term antipsychotic exposure induced mixed eye movement alterations that were associated with non-remission at three-year follow-up. This finding provides a reference for the development of personalized risk stratification frameworks and targeted intervention strategies in CHR populations.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 196-203"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Highlights","authors":"","doi":"10.1016/S0920-9964(25)00343-3","DOIUrl":"10.1016/S0920-9964(25)00343-3","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"284 ","pages":"Page A1"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145262718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing the sensori-/psychomotor domain in schizophrenia spectrum disorders: From clinical observation to translational innovation","authors":"Dusan Hirjak ,&nbsp;Sebastian Volkmer ,&nbsp;Victor Pokorny ,&nbsp;Vijay A. Mittal","doi":"10.1016/j.schres.2025.09.021","DOIUrl":"10.1016/j.schres.2025.09.021","url":null,"abstract":"<div><div>Sensori-/psychomotor dysfunction has historically been an underrecognized domain in schizophrenia spectrum disorders (SSD), often overshadowed by a narrow focus on medication-induced side effects such as acute extrapyramidal motor symptoms, akathisia, dystonia, parkinsonism, and tardive dyskinesia. Two decades ago, research in this area was largely confined to these pharmacologically related phenomena, as well as to neurological soft signs (NSS) and catatonia. In the last ten years, however, the sensori-/psychomotor domain has garnered renewed interest as a core feature of SSD—relevant not only for symptom profiling but also for early detection, prognostic stratification, and individualized treatment planning across the lifespan. This narrative review synthesizes major advances from the past five years across Psychiatry, Neuroscience, Human Movement Science, and Affective Computing. It highlights a paradigm shift from traditional hand-based sensori-/psychomotor assessments toward novel, scalable approaches for investigating sensori-/psychomotor dysfunction. Emerging tools—such as actigraphy, 3D motion capture systems, standardized sensorimotor tasks, and multimodal neuroimaging—now allow for more objective, multimodal assessment of sensori-/psychomotor behavior, including gesture dynamics and patterns of physical inactivity. In parallel, computational innovations have enabled the large-scale analysis of sensori-/psychomotor abnormalities, including retrospective mining of unstructured clinical notes through natural language processing and machine learning techniques. Together, these developments underscore the shifting view of sensori-/psychomotor dysfunction as more than behavioral epiphenomena or drug effects. We argue that the integration of emerging technologies and refined methodologies into clinical workflows is essential for translating research findings into personalized, real-world care of mental disorders across the lifespan.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 185-195"},"PeriodicalIF":3.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal study of stress-sensitivity trajectories and schizotypy: Retrospective and momentary daily-life assessments of stress appraisals","authors":"Alena Gizdic ,&nbsp;Pilar Torrecilla ,&nbsp;Ginette Lafit ,&nbsp;Inez Myin-Germeys ,&nbsp;Thomas R. Kwapil ,&nbsp;Neus Barrantes-Vidal","doi":"10.1016/j.schres.2025.09.013","DOIUrl":"10.1016/j.schres.2025.09.013","url":null,"abstract":"<div><div>Heightened stress-sensitivity is a vulnerability factor to the extended psychosis phenotype (i.e., schizotypy), but longitudinal studies on its development and association with schizotypy are lacking. This study examines the stability of stress-sensitivity as a trait and its trajectories over time, assessed both retrospectively and in daily life. Additionally, it explores whether individuals with varying stress-sensitivity trajectories exhibit different levels of positive and negative schizotypy. Stress-sensitivity was measured in non-clinical young adults at three time points (T3 n = 102, age = 23.5; T4 n = 89, age = 25; T5 n = 168, age = 28) both retrospectively with Perceived Stress Scale and momentarily with experience sampling methodology. Schizotypy dimensions were assessed at the final time point. Three longitudinal modeling techniques were used to assess and classify individuals’ trajectories of stress over time. Stress-sensitivity exhibited overall stability over time across both retrospective and momentary measures, revealing two trajectory classes (high and low). Stability persisted in high stress-sensitivity classes, except for momentary situational stress. Individuals with persistently high stress-sensitivity over 4.5 years reported elevated positive and negative schizotypy. Retrospective measure revealed a large effect for positive and a medium effect for negative schizotypy, while no such associations for momentary assessments. Findings indicate that stress-sensitivity is a stable trait, even when assessed in young adults. Stability was more effectively captured through retrospective rather than momentary measures−consistent with the contextually-driven nature of momentary responses. These results align with stress-sensitivity role in the causal pathway of the extended psychosis phenotype. Understanding the characterization of stress-sensitivity may offer insight into risk, protection, and mechanisms in psychosis development.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 175-182"},"PeriodicalIF":3.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}