Schizophrenia Research最新文献_第2页

Self-other boundary under social threat in schizophrenia 精神分裂症患者社交威胁下的 "自我-他者 "界限

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-09-26 DOI: 10.1016/j.schres.2024.09.018

{"title":"Self-other boundary under social threat in schizophrenia","authors":"","doi":"10.1016/j.schres.2024.09.018","DOIUrl":"10.1016/j.schres.2024.09.018","url":null,"abstract":"<div><div>Spatial representation of the self plays a vital role constructing our sense of bodily self-boundary that distinguishes the self from others. This perceptual border, known as the peripersonal space (PPS), has been suggested to be altered in individuals with schizophrenia (SZ). PPS represents a protective defensive zone that triggers alarm signals upon threat detection; thus disrupted PPS could lead to social interactional difficulties. However, very little is known about the impact of threat on PPS.</div><div>To address this gap, a visual-tactile response-time (RT) experiment was conducted in immersive virtual reality (VR) for SZ and matched controls (CO). Participants were asked to detect a tactile vibration on their hand while an avatar (either threatening or neutral) approached them. Avatars were presented at different distance from the participants. PPS size and slope were estimated by identifying significant RT drop at the hypothesized self-other boundary. We also examined the relationship between PPS parameters, clinical symptoms and social disconnection.</div><div>There was no overall group difference in PPS size. Perceived social threat posed in the avatars sharpened the self-boundary in CO but not in SZ. In SZ, shallower PPS slope was associated with delusion, persecution, negative symptoms and loneliness but not in CO.</div><div>These results show that the regulation of self-other boundary in response to impending social threat may be maladaptive in SZ. Further research is needed on the causal mechanisms between self-disturbance and social impairments.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142324117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of sexual orientation with symptom profiles in first-episode schizophrenia spectrum disorders 性取向与首发精神分裂症谱系障碍症状特征的关系

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-09-26 DOI: 10.1016/j.schres.2024.09.027

引用次数: 0

The depiction of people with schizophrenia in news media: A cross-national analysis 新闻媒体对精神分裂症患者的描述：跨国分析

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-09-23 DOI: 10.1016/j.schres.2024.09.016

引用次数: 0

Corrigendum to “Natural language processing for defining linguistic features in schizophrenia: A sample from Turkish speakers” [Schizophr. Res. 266 (2024) 183–189] 对 "定义精神分裂症语言特征的自然语言处理：来自土耳其语使用者的样本"[Schizophr. Res. 266 (2024) 183-189] 更正

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-09-23 DOI: 10.1016/j.schres.2024.09.017

引用次数: 0

Arousal responses to personal space intrusions in psychotic illness: A virtual reality study 精神病患者对个人空间侵入的唤醒反应：虚拟现实研究

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-09-20 DOI: 10.1016/j.schres.2024.09.004

{"title":"Arousal responses to personal space intrusions in psychotic illness: A virtual reality study","authors":"","doi":"10.1016/j.schres.2024.09.004","DOIUrl":"10.1016/j.schres.2024.09.004","url":null,"abstract":"<div><h3>Background</h3><p>Prior studies have found that individuals with schizophrenia often have an enlarged “personal space”. However, the neurocognitive mechanisms underlying this consistent finding remain unknown.</p></div><div><h3>Methods</h3><p>The well-validated Stop Distance Procedure was used to measure the personal space preferences of individuals with psychotic disorders (PD, <em>N</em> = 22) and demographically-matched healthy controls (HC, <em>N</em> = 20) in response to human and virtual (avatar) intruders. Physiological arousal and subjective discomfort were measured during intrusions into personal space and modeled across different interpersonal distances. Additionally, participants were interviewed to assess their subjective awareness of their personal space preferences.</p></div><div><h3>Results</h3><p>Personal space measurements with humans and avatars were highly correlated and reliable over repeated trials, and influenced by the displayed emotion and gender of the intruders, in both groups. The PD group exhibited a larger personal space than the HC group (all <em>p</em> < 0.028), and the size of personal space with avatar intruders was significantly correlated with positive symptom severity in the PD subjects. Moreover, the magnitude of arousal responses to personal space intrusions was proportional to a power (exponent) of the distance between subjects and intruders, with a significantly smaller exponent in the PD (compared to the HC) for both human (<em>p</em> = 0.026) and avatar (<em>p</em> = 0.011) intruders, indicating a less steep function. Lastly, much of the participants' qualitative impressions of their personal space behaviors were consistent or correlated with the quantitative findings, reflecting some awareness of the determinants of personal space.</p></div><div><h3>Conclusions</h3><p>These findings reveal both intact and altered aspects of personal space regulation in psychotic disorders, and the potential utility of personal space measurements, given their high reliability, to serve as objective targets of interventions.</p></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suicidality among clients in a network of coordinated specialty care (CSC) programs for first-episode psychosis: Rates, changes in rates, and their predictors 初发精神病协调专科护理（CSC）计划网络中客户的自杀率：自杀率、自杀率的变化及其预测因素

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-09-19 DOI: 10.1016/j.schres.2024.07.054

{"title":"Suicidality among clients in a network of coordinated specialty care (CSC) programs for first-episode psychosis: Rates, changes in rates, and their predictors","authors":"","doi":"10.1016/j.schres.2024.07.054","DOIUrl":"10.1016/j.schres.2024.07.054","url":null,"abstract":"<div><h3>Background</h3><p>People experiencing their first episode of psychosis have high risk of suicide, and programs specializing in early psychosis have not always achieved reduced risk. The present study analyzes patterns of suicide ideation, self-harm, and suicide attempts within the Connection Learning Healthcare System of 23 early psychosis programs in Pennsylvania and Maryland that follow the Coordinated Specialty Care treatment model.</p></div><div><h3>Method</h3><p>People with first episode psychosis (<em>n</em> = 1101) were assessed at admission and every six months using a standardized battery that included self-reported past-month ideation and clinician-reported past-six-month ideation, self-harm, and suicide attempts.</p></div><div><h3>Results</h3><p>At admission, there were 28 % rates of self-reported past-month suicide ideation and 52 % rates clinician-reported past-six-month suicide ideation, 23 % rate of clinician-reported self-harm, and 15 % rate of attempts. After the first six months of treatment there were significantly lower rates of clinician-reported suicidality (with reductions of at least 77 %), and after the first year of treatment there was significantly lower self-reported ideation (with approximately 54 % reporting lower past-month ideation). Changes were not accounted for by differential early discharge. A range of psychosocial variables predicted within- and between-subject variability in suicidality. Social and role functioning, depressive symptom severity, and a sense of recovery were significant within-subject predictors of all four measures of suicidality.</p></div><div><h3>Conclusions</h3><p>Compared to admission, we observed substantially lower rates of suicidality within the first year of treatment for clients with first episode psychosis in Coordinated Specialty Care. Reductions were predicted by some of the variables targeted by the treatment model.</p></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated linguistic analysis in youth at clinical high risk for psychosis 对精神病临床高危青少年进行自动语言分析

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-09-17 DOI: 10.1016/j.schres.2024.09.009

{"title":"Automated linguistic analysis in youth at clinical high risk for psychosis","authors":"","doi":"10.1016/j.schres.2024.09.009","DOIUrl":"10.1016/j.schres.2024.09.009","url":null,"abstract":"<div><p>Identifying individuals at clinical high risk for psychosis (CHR<img>P) is crucial for preventing psychosis and improving the prognosis for schizophrenia. Individuals at CHR-P may exhibit mild forms of formal thought disorder (FTD), making it possible to identify them using natural language processing (NLP) methods. In this study, speech samples of 62 CHR-P individuals and 45 healthy controls (HCs) were elicited using Thematic Apperception Test images. The evaluation involved various NLP measures such as semantic similarity, generic, and part-of-speech (POS) features. The CHR-P group demonstrated higher sentence-level semantic similarity and reduced mean image-to-text similarity. Regarding generic analysis, they demonstrated reduced verbosity and produced shorter sentences with shorter words. The POS analysis revealed a decrease in the utilization of adverbs, conjunctions, and first-person singular pronouns, alongside an increase in the utilization of adjectives in the CHR-P group compared to HC. In addition, we developed a machine-learning model based on 30 NLP-derived features to distinguish between the CHR-P and HC groups. The model demonstrated an accuracy of 79.6 % and an AUC-ROC of 0.86. Overall, these findings suggest that automated language analysis of speech could provide valuable information for characterizing FTD during the clinical high-risk phase and has the potential to be applied objectively for early intervention for psychosis.</p></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rates and predictors of service disengagement in first episode psychosis: Results from a 2-year follow-up study in an Italian real-world care setting 首次发病的精神病患者脱离服务的比率和预测因素：意大利真实世界护理环境中的两年随访研究结果

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-09-17 DOI: 10.1016/j.schres.2024.09.015

{"title":"Rates and predictors of service disengagement in first episode psychosis: Results from a 2-year follow-up study in an Italian real-world care setting","authors":"","doi":"10.1016/j.schres.2024.09.015","DOIUrl":"10.1016/j.schres.2024.09.015","url":null,"abstract":"<div><h3>Aim</h3><p>Service disengagement is a major problem for “Early Intervention in Psychosis” (EIP). Understanding predictors of engagement is also crucial to increase effectiveness of mental health treatments, especially in young people with First Episode Psychosis (FEP). No Italian investigation on this topic has been reported in the literature to date. The goal of this research was to assess service disengagement rate and predictors in an Italian sample of FEP subjects treated within an EIP program across a 2-year follow-up period.</p></div><div><h3>Methods</h3><p>All patients were young FEP help-seekers, aged 12–35 years, recruited within the “Parma Early Psychosis” (Pr-EP) program. At baseline, they completed the Positive And Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning (GAF) scale. Univariate and multivariate Cox regression analyses were carried out.</p></div><div><h3>Results</h3><p>489 FEP subjects were enrolled in this study. Across the follow-up, a 26 % prevalence rate of service disengagement was found. Particularly strong predictors of disengagement were living with parents, poor treatment adherence at entry and a low baseline PANSS “Disorganization” factor score.</p></div><div><h3>Conclusion</h3><p>More than a quarter of our FEP individuals disengaged the Pr-EP program during the first 2 years of intervention. A possible solution to reduce disengagement and to facilitate re-engagement of these young patients might be to offer the option of low-intensity monitoring and support, also via remote technology and tele-mental health care.</p></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0920996424004249/pdfft?md5=6e9e2f5c0963884c7556fb4240094f3c&pid=1-s2.0-S0920996424004249-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lower levels of kainate receptors, but not AMPA or NMDA receptors, in Brodmann's area (BA) 9, but not BA 10, from a subgroup of people with schizophrenia who have a marked deficit in cortical muscarinic M1 receptors 布罗德曼第 9 区（BA）（而非第 10 区）的 kainate 受体（而非 AMPA 或 NMDA 受体）水平较低，而这些受体来自皮质毒蕈碱 M1 受体明显缺乏的精神分裂症患者亚群。

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-09-17 DOI: 10.1016/j.schres.2024.09.014

{"title":"Lower levels of kainate receptors, but not AMPA or NMDA receptors, in Brodmann's area (BA) 9, but not BA 10, from a subgroup of people with schizophrenia who have a marked deficit in cortical muscarinic M1 receptors","authors":"","doi":"10.1016/j.schres.2024.09.014","DOIUrl":"10.1016/j.schres.2024.09.014","url":null,"abstract":"<div><p>In a previous study on ionotropic glutamate receptors, we have shown that [<sup>3</sup>H]kainate, but not [<sup>3</sup>H]AMPA or [<sup>3</sup>H]NMDA, receptor binding was lower in Brodmann's area (BA) 9 from people with schizophrenia. Subsequently, we defined a subgroup within the syndrome of schizophrenia who are termed the Muscarinic Receptor Deficit subgroup of Schizophrenia (MRDS) as they have markedly lower levels of [<sup>3</sup>H]pirenzepine binding to the muscarinic M1 receptor. The previous glutamate receptor study did not contain enough people with MRDS and other forms of schizophrenia (non-MRDS) to study any subgroup-specific differences. Hence, in this study we first measured [<sup>3</sup>H]pirenzepine binding to the muscarinic M1 receptor to confirm the MRDS subgroup, then measured [<sup>3</sup>H]kainate, [<sup>3</sup>H]AMPA and [<sup>3</sup>H]NMDA receptor binding using autoradiography in BA 9 from people with MRDS, non-MRDS and controls. We also measured binding in BA 10 as our gene expression study indicated that BA 10 is disproportionally affected by the molecular pathology of schizophrenia. As expected, due to case-selection criteria, [<sup>3</sup>H]pirenzepine binding to the M1 receptor was lower in BA 9 and BA 10 from people with MRDS, although more profound in BA 10. [<sup>3</sup>H]kainate receptor binding was lower only in BA 9 from people with MRDS, while [<sup>3</sup>H]AMPA and [<sup>3</sup>H]NMDA receptor binding was not altered in either region. Muscarinic M1 receptors and kainate receptors are both located on glutamatergic pyramidal neurons so a perturbation in both receptors could indicate altered excitatory neurotransmission in BA 9 from people with MRDS.</p></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal electrophysiological alterations are associated with cognition in early course psychosis 视网膜电生理改变与早期精神病的认知能力有关

IF 3.6 2区医学

Schizophrenia Research Pub Date : 2024-09-17 DOI: 10.1016/j.schres.2024.09.013

引用次数: 0