Schizophrenia Research最新文献

{"title":"A mixed-methods study exploring the benefits, drawbacks, and utilization of data in care: Findings from the EPI-CAL early psychosis learning health care network","authors":"Sabrina Ereshefsky ,&nbsp;Regina Gemignani ,&nbsp;Mark Savill ,&nbsp;Katherine C. Sanford ,&nbsp;Lindsay M. Banks ,&nbsp;Valerie L. Tryon ,&nbsp;Kathleen E. Nye ,&nbsp;Katherine M. Pierce ,&nbsp;Madison J. Miles ,&nbsp;Chelyah Miller ,&nbsp;Khanh Linh H. Nguyen ,&nbsp;Nitasha Sharma ,&nbsp;Merissa Kado-Walton ,&nbsp;Christopher K. Hakusui ,&nbsp;Leigh Smith ,&nbsp;Viviana E. Padilla ,&nbsp;Amanda P. McNamara ,&nbsp;Maliha Safdar ,&nbsp;Andrew J. Padovani ,&nbsp;Rachel L. Loewy ,&nbsp;Tara A. Niendam","doi":"10.1016/j.schres.2025.01.018","DOIUrl":"10.1016/j.schres.2025.01.018","url":null,"abstract":"<div><div>Using data collected in routine care delivery to inform treatment is a key feature of a learning health system (LHS). In this study, we explored the experiences of service users and providers adopting measurement-based care (MBC) in early psychosis (EP) specialty care settings. Qualitative interviews were conducted with 32 providers and 12 service users across 18 programs in the Early Psychosis Intervention Network of California (EPI-CAL). These findings were compared with quantitative data from Beehive, EPI-CAL's data collection and review application. Regarding the clinical benefits of MBC in EP, three broad themes were identified – supporting safety monitoring and response, the assessment process, and delivery of psychotherapy. Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation Outside of direct clinical care, Beehive was considered to support clinical supervision and external reporting, while service users reported data collection facilitated selfreflection. In the quantitative Beehive application data collected from 23 EP programs, high utilization of the safety alert system was evident (349 alerts in total, of which 338 [96.85 %] were resolved at a median of 2.03 days). However, service users' key survey data was only reviewed by assigned providers in 32.22 % (142 of 441) of cases. While providers and service users saw many benefits to Beehive, utilization was highly inconsistent outside of the alert system. Going forward, further consideration of how best to support EP providers to consistently use data in care is necessary to maximize the utility of the LHS approach and positively impact outcomes.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 157-166"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creating a collaborative culture of learning within a network of community mental health early psychosis programs in Texas","authors":"Molly A. Lopez ,&nbsp;Samantha J. Reznik ,&nbsp;Vanessa V. Klodnick ,&nbsp;Deborah Cohen ,&nbsp;Neely Myers ,&nbsp;Justin F. Rousseau ,&nbsp;Nazan Aksan ,&nbsp;Eliel de Oliveira ,&nbsp;Stephen M. Strakowski","doi":"10.1016/j.schres.2024.12.009","DOIUrl":"10.1016/j.schres.2024.12.009","url":null,"abstract":"<div><div>Learning Health Systems (LHSs) promise meaningful health care improvement through the ongoing use of data, including the lived experience of diverse constituents, such as people participating in and providing services. Most LHSs operate within a specific healthcare system, typically hospital-based, under a common electronic health record (EHR) and management structure. The Early Psychosis Intervention Network in Texas (EPINET-TX) is a novel case study of a developing LHS across 16 independent community mental health clinics operating state-funded coordinated specialty care (CSC) programs for early psychosis. EPINET-TX is a partnership among a multidisciplinary research hub and state and local entities. Grounded in participatory research frameworks, multiple strategies were utilized to align partners around learning goals, build data use competencies, enhance researchers' understanding of program context, and cultivate a continuous performance improvement mindset. Key strategies for developing a LHS culture included a) intentionally building collaborative relationships, b) establishing shared values and governance, c) collaborating in research and change-focused workgroups, and d) sharing learning and growth experiences. For CSC programs operating within the public mental health system, the LHS framework provides a promising model to foster quality improvement, innovation, and action-oriented participatory research.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 1-7"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing the relationship between personality dimensions and psychosis-specific clinical characteristics","authors":"Youjin Jenny Jang ,&nbsp;Walid Yassin ,&nbsp;Raquelle Mesholam-Gately ,&nbsp;Elliot S. Gershon ,&nbsp;Sarah Keedy ,&nbsp;Godfrey G. Pearlson ,&nbsp;Carol A. Tamminga ,&nbsp;Jennifer McDowell ,&nbsp;David A. Parker ,&nbsp;Kodiak Sauer ,&nbsp;Matcheri S. Keshavan","doi":"10.1016/j.schres.2025.01.002","DOIUrl":"10.1016/j.schres.2025.01.002","url":null,"abstract":"<div><h3>Background</h3><div>Past studies associating personality with psychosis have been limited by small nonclinical samples and a focus on general symptom burden. This study uses a large clinical sample to examine personality's relationship with psychosis-specific features and compare personality dimensions across clinically and neurobiologically defined categories of psychoses.</div></div><div><h3>Methods</h3><div>A total of 1352 participants with schizophrenia, schizoaffective disorder, and bipolar with psychosis, as well as 623 healthy controls (HC), drawn from the Bipolar-Schizophrenia Network for Intermediate Phenotypes (BSNIP-2) study, were included. Three biomarker-derived biotypes were used to separately categorize the probands. Mean personality factors (openness, conscientiousness, extraversion, agreeableness, and neuroticism) were compared between HC and proband subgroups using a generalized linear model. A robust linear regression was utilized to determine personality differences across biotypes and diagnostic subgroups. Associations between personality factors and cognition were determined through Pearson's correlation. A canonical correlation was run between the personality factors and general functioning, positive symptoms, and negative symptoms to delineate the relationship between personality and clinical outcomes of psychosis.</div></div><div><h3>Results</h3><div>There were significant personality differences between the proband and HC groups across all five personality factors. Overall, the probands had higher neuroticism and lower extraversion, agreeableness, conscientiousness, and openness. Openness showed the greatest difference across the diagnostic subgroups and biotypes, and greatest correlation with cognition. Openness, agreeableness, and extraversion had the strongest associations with symptom severity.</div></div><div><h3>Conclusions</h3><div>Individuals with psychotic disorders have different personality traits compared to HC. In particular, openness may be relevant in distinguishing psychosis-specific phenotypes and experiences, and associated with biological underpinnings of psychosis, including cognition. Further studies should identify potential causal factors and mediators of this relationship.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 88-96"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binaural hearing impairment in patients with schizophrenia: A multicenter study","authors":"Lei Liu ,&nbsp;Yu Xia ,&nbsp;Liangjie Chen ,&nbsp;Feng Zou ,&nbsp;Shenglin She ,&nbsp;Liang Li ,&nbsp;Yingjun Zheng","doi":"10.1016/j.schres.2025.01.013","DOIUrl":"10.1016/j.schres.2025.01.013","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 175-177"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive function at first episode in patients subsequently developing treatment-resistant schizophrenia","authors":"Juan M. Aguirre ,&nbsp;Camila Díaz Dellarossa ,&nbsp;Daniella Barbagelata ,&nbsp;Javiera Vásquez ,&nbsp;Cristián Mena ,&nbsp;Ángeles Tepper ,&nbsp;Juan Pablo Ramírez-Mahaluf ,&nbsp;David Aceituno ,&nbsp;Rubén Nachar ,&nbsp;Juan Undurraga ,&nbsp;Alfonso González-Valderrama ,&nbsp;Nicolas A. Crossley","doi":"10.1016/j.schres.2025.01.017","DOIUrl":"10.1016/j.schres.2025.01.017","url":null,"abstract":"<div><h3>Background</h3><div>Research on cognitive functions in treatment-resistant schizophrenia (TRS) has focused on chronic patients, complicating the distinction between disease-related deficits from those influenced by chronicity or antipsychotic exposure. Identifying early cognitive differences could offer insights into the nature of TRS cognitive performance and serve as potential markers of treatment resistance.</div></div><div><h3>Methods</h3><div>Cohort study of 81 first-episode schizophrenia patients from Chile. Patients were followed-up and classified as TRS if they met TRRIP criteria or were prescribed clozapine at any point. 57 healthy controls were recruited for group comparisons. Cognitive performance was assessed using the MATRICS Consensus Cognitive Battery.</div></div><div><h3>Results</h3><div>51 patients were allocated to the treatment-responsive group (TRESP) and 30 to the TRS sample. Multivariable analyses controlling for age and sex revealed a worse TRS performance in processing speed, verbal fluency, attention/vigilance and working memory (<em>p</em> values &lt;0.05). After multiple comparison corrections, only speed of processing remained significant. When accounting for symptom severity, antipsychotic dose and duration of untreated psychosis (DUP), TRS subjects still showed significantly lower processing speed (BACS, <em>p</em> = 0.036; TMT-A, <em>p</em> = 0.027), which was not significant after correcting for multiple comparisons.</div></div><div><h3>Discussion</h3><div>TRS patients show slower processing speed compared to TRESP already during first episode, that is not entirely driven by symptom severity, antipsychotic dose and DUP. Processing speed emerges as an early deficit that could aid in the timely identification of patients on a treatment resistance trajectory and facilitate the prompt implementation of treatments such as clozapine.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 178-184"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidity of anorexia nervosa and schizophrenia: A systematic review","authors":"Rachel M. Hechinger ,&nbsp;Kristin N. Javaras ,&nbsp;Kathryn Eve Lewandowski","doi":"10.1016/j.schres.2025.01.010","DOIUrl":"10.1016/j.schres.2025.01.010","url":null,"abstract":"<div><div>Research on the intersection between eating disorders and schizophrenia (SCZ) has mainly focused on binge eating, since increased appetite and metabolic side effects are common during antipsychotic use. However, the prevalence of restrictive eating and anorexia nervosa may be higher in people with SCZ than in the general population, and evidence suggests shared genetic liability for SCZ and anorexia nervosa (AN). The aim of this systematic review was to examine the prevalence, psychological and biological mechanisms, and theoretical underpinnings underlying the co-occurrence of AN and SCZ. We identified 40 articles that met inclusion criteria. Evidence suggested that the prevalence of AN in patients with SCZ is higher than would be expected in the general population; conversely, evidence regarding the prevalence of SCZ in AN was mixed. Psychological mechanisms underlying AN in people with SCZ fell into three categories: positive symptoms, negative symptoms, and atypical pathways. A limited literature generally supports the hypothesis of higher prevalence of AN in patients with SCZ, but there are few studies in this area. Studies of the prevalence of SCZ in AN yield more mixed findings, although these studies are also relatively small and few. Further, studies of both types tend to include only clinically ascertained samples, which limits the generalizability of findings beyond patients. Larger, better-designed studies may improve identification and treatment of people with co-occurring SCZ and AN.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 185-193"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 outbreak in a ward led three patients to discontinue clozapine due to neutropenia: Call for urgent considerations regarding clozapine regulation in Japan","authors":"Yuki Kikuchi ,&nbsp;Sota Ueno ,&nbsp;Bunichiro Onodera ,&nbsp;Hiroaki Tanifuji ,&nbsp;Hiroshi Komatsu ,&nbsp;Hiroaki Tomita","doi":"10.1016/j.schres.2025.01.024","DOIUrl":"10.1016/j.schres.2025.01.024","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 194-195"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychopathology trajectories and relapse in first episode schizophrenia with assured long-acting injectable adherence over 24 months","authors":"Smit Retha,&nbsp;Luckhoff Hilmar,&nbsp;Phahladira Lebogang,&nbsp;Kilian Sanja,&nbsp;Emsley Robin,&nbsp;Asmal Laila","doi":"10.1016/j.schres.2025.01.007","DOIUrl":"10.1016/j.schres.2025.01.007","url":null,"abstract":"<div><h3>Background</h3><div>Relapse following a first episode of schizophrenia (FES) is common and often results in serious adverse psychosocial consequences. Treatment non-adherence is a key risk factor for relapse, but why relapse occurs despite antipsychotic treatment adherence remains unclear. This study examined the differences in FES psychopathology trajectories over 24-months with assured long-acting injectable antipsychotic (LAIA) treatment, to control for treatment adherence between those who relapsed and those who did not and what moderates these group differences.</div></div><div><h3>Methodology</h3><div>We collected clinical and socio-demographic data from 107 participants with FES treated with LAIA medication over a 24-month period. Relapse was defined using the modified Csernansky criteria. Substance use was assessed through participant and family interviews and urine toxicology. Linear mixed model repeated measures models were constructed to (1) compare psychopathology trajectories over 24 months between relapse versus non-relapse groups (2) to examine factors moderating differential trajectories between the groups.</div></div><div><h3>Results</h3><div>Positive symptom trajectories were significantly worse in the relapse compared to non-relapse group over 24 months (F(8, 649 = 3.29), <em>p</em> = 0.001). More severe childhood trauma (CT), in particular physical abuse (PA) (F(39, 298 = 1.78), <em>p</em> = 0.004), was associated with worse positive symptom trajectories over 24 months in those who experienced a relapse event.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that the examination of a history of CT and, in particular childhood PA measures for relapse in individuals with FES, is important.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 8-14"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synaptic dysfunctions in schizophrenia: Commonalities and divergences in Chinese and Indian populations","authors":"Aheli Chakraborty ,&nbsp;Nivedhitha Mukesh ,&nbsp;Anil Annamneedi","doi":"10.1016/j.schres.2025.01.012","DOIUrl":"10.1016/j.schres.2025.01.012","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 106-107"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using pupillometry to predict outcome in cognitive behavioral therapy for negative symptoms of schizophrenia","authors":"Christophe Delay ,&nbsp;Peter Link ,&nbsp;Jason Holden ,&nbsp;Eric Granholm","doi":"10.1016/j.schres.2025.01.014","DOIUrl":"10.1016/j.schres.2025.01.014","url":null,"abstract":"<div><h3>Background</h3><div>Clinical trials of cognitive-behavioral therapy (CBT) for negative symptoms of schizophrenia have provided mixed results, perhaps because some patients are more likely to benefit than others. Patients likely to benefit may be those with greater pre-treatment motivation. To better examine the effects of motivation on treatment outcome, more objective measures of motivation are needed. Pupillary responses provide an objective biomarker of cognitive effort and motivation, with greater dilation associated with greater effort and motivation.</div></div><div><h3>Aims</h3><div>The current study examined whether pre-treatment baseline pupil dilation predicted motivation and pleasure (MAP) negative symptom reduction in an open clinical trial of CBT for individuals with schizophrenia.</div></div><div><h3>Methods</h3><div>Pupil dilation was recorded during the digit-span task at low (3 digits), moderate (6 digits) and high (9 digits) loads in participants with schizophrenia or schizoaffective disorder (<em>N</em> = 31) with persistent negative symptoms prior to delivery of mobile-assisted CBT for negative symptoms (mCBTn).</div></div><div><h3>Results</h3><div>Greater pre-treatment pupil dilation during low, but not moderate or high, loads of the digit-span task significantly predicted greater reduction in MAP negative symptoms. However, while MAP negative symptoms improved throughout treatment, pupil dilation did not significantly change throughout treatment for any digit-span loads.</div></div><div><h3>Implications</h3><div>Pupil dilation may provide a much-needed prognostic biomarker of patients most likely to benefit from CBT for MAP symptoms, but did not change with change in MAP symptoms.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 135-142"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}