Schizophrenia ResearchPub Date : 2026-06-01Epub Date: 2026-03-11DOI: 10.1016/j.schres.2026.02.018
L. Palaniyappan , V.S. Sreeraj , G. Venkatasubramanian , A. Voppel
{"title":"Why is it hard to assess thought disorder? Clarifying the third domain of psychosis","authors":"L. Palaniyappan , V.S. Sreeraj , G. Venkatasubramanian , A. Voppel","doi":"10.1016/j.schres.2026.02.018","DOIUrl":"10.1016/j.schres.2026.02.018","url":null,"abstract":"<div><div>Formal Thought Disorder (FTD) presents psychiatry's central paradox: it is one of the robust predictors of poor outcomes and polygenic risk in psychosis yet remains poorly defined and rarely measured clinically. We systematically reviewed 50 years of FTD assessment (16 rating scales, 32 factor analyses) to understand this paradox. Research to date has implicitly treated FTD as a natural kind, a latent entity that causes observable signs. Yet, empirical evidence contradicts this assumption: we find radical heterogeneity in construct definition, non-replicability of factor structures at the item level, and no universally essential properties across items. We propose measuring FTD as a Constituted Practical Entity: a probabilistic cluster of linguistic-cognitive features whose interaction produces communication failure. In this framework, no single feature is necessary or sufficient; dysfunction emerges from their relationships, not from a single latent process. This reconceptualization reconciles the multi-dimensional nature of FTD with our attempts to measure it and offers a clear research path: establish consensus constituents, measure their interactions, and develop computational tools. Without addressing the conceptual foundations, technical advances will only perpetuate existing confusions. Our framework clarifies what is being measured in the name of FTD and guides the development of computational tools and clinically meaningful targets for this third domain of psychosis.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"292 ","pages":"Pages 41-52"},"PeriodicalIF":3.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147387779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Schizophrenia ResearchPub Date : 2026-06-01Epub Date: 2026-03-09DOI: 10.1016/j.schres.2026.03.005
Daniel Freeman , Laina Rosebrock , Felicity Waite
{"title":"Patient expectations for outcome with psychological intervention for psychosis","authors":"Daniel Freeman , Laina Rosebrock , Felicity Waite","doi":"10.1016/j.schres.2026.03.005","DOIUrl":"10.1016/j.schres.2026.03.005","url":null,"abstract":"<div><h3>Background</h3><div>Initial patient perceptions of a treatment's credibility, and expectations for improvement, have been shown to predict to a small degree outcomes for common mental health disorders. This study aimed to discover: how patients with psychosis initially perceive psychological therapy's credibility and likely success; whether there are predictors of these first views; and, primarily, if such ideas predict improvement in persecutory delusions.</div></div><div><h3>Methods</h3><div>We analysed first therapy session data on credibility and expectancy from 195 patients with non-affective psychosis taking part in clinical trials treating persecutory delusions. Baseline assessments before randomisation to therapy were used to identify potential predictors of credibility and expectancy. First session credibility and expectancy scores were tested as predictors of persecutory delusion severity six months later.</div></div><div><h3>Results</h3><div>Most patients were optimistic about therapy's potential. Baseline delusion severity did not predict credibility, β = −0.02, <em>p</em> = .742, or expectancy, β = −0.03, <em>p</em> = .632. Higher psychological well-being predicted higher levels of expectancy, β = 0.23, <em>p</em> = .001. Higher levels of credibility, β = −0.17, <em>p</em> = .021, and expectancy, β = −0.17, <em>p</em> = .020, predicted lower severity of persecutory delusions six months later. Credibility, β = 0.00, <em>p</em> = .970, and expectancy, β = −0.21, <em>p</em> = .074, did not significantly predict uptake of therapy sessions.</div></div><div><h3>Conclusions</h3><div>Treatment credibility and expectancy may account for a small proportion of improvement when psychological interventions are used to treat severe paranoia. The results are comparable to those for common mental health disorders. There was little prediction of patient variability in credibility and expectancy. It will be helpful to understand a patient's initial views on intervention so that any concerns can be addressed.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"292 ","pages":"Pages 21-27"},"PeriodicalIF":3.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147387781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Negative symptoms and resting state functional connectivity: Leveraging ecological momentary assessment and individual-specific techniques","authors":"Nada Dalloul , Sridhar Kandala , Erin Moran , Deanna M. Barch","doi":"10.1016/j.schres.2026.02.016","DOIUrl":"10.1016/j.schres.2026.02.016","url":null,"abstract":"<div><div>There are indications that motivational deficits in psychotic and mood disorders are related to differences in functional connectivity. However, the literature is mixed, partly due to the limitations of traditional methods in accounting for individual variability. Ecological momentary assessment (EMA) and individual-specific techniques can account for such variability. By leveraging these methods, this study aims to elucidate transdiagnostic relationships between motivational deficits and resting-state functional connectivity. 144 participants (29 schizophrenia/schizoaffective; 38 bipolar, 37 major depressive, 40 controls) completed EMA on motivation and pleasure (MAP) and resting-state BOLD scans. Individual-specific network connectivity matrices were calculated with an empirically validated template-matching technique. Bayesian hierarchical regression models assessed relationships between anticipatory and consummatory MAP and within-network connectivity, participation coefficient, and number of vertices for eight networks (default mode, cingulo-opercular, dorsal attention, ventral attention, salience, fronto-parietal, dorsal somato-motor, ventral somato-motor). Analyses demonstrated intact MAP for bipolar and major depressive disorders, and elevated MAP for schizophrenia/schizoaffective disorder. Moreover, MAP was positively related to within-network connectivity of the dorsal attention network, positively related to participation coefficient of the ventral attention network in schizophrenia/schizoaffective disorder, negatively related to within-network connectivity of the salience network in schizophrenia/schizoaffective disorder, and positively related to spatial extent of the salience network in controls. Overall, the findings highlight the role of attentional processes in MAP and suggest that underlying neural mechanisms vary by diagnosis. The results emphasize the complexity of MAP deficits and underscore the need for research to consider inter-individual variability to fully understand their phenomenology and neural basis.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"292 ","pages":"Pages 28-40"},"PeriodicalIF":3.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147387782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Schizophrenia ResearchPub Date : 2026-06-01Epub Date: 2026-03-09DOI: 10.1016/j.schres.2026.02.012
Sophie Elise Richards , Andrea Davis, Cheryl Blake, Helen Errington, Jack Singh, Charles Fernyhough , Peter Moseley , Padmavati Ramachandran , Neil Thomas , Susan Lee Rossell , Wei Lin Toh
{"title":"Challenges and priorities in researching and managing altered perceptual experiences: Shared academic and lived experience perspectives","authors":"Sophie Elise Richards , Andrea Davis, Cheryl Blake, Helen Errington, Jack Singh, Charles Fernyhough , Peter Moseley , Padmavati Ramachandran , Neil Thomas , Susan Lee Rossell , Wei Lin Toh","doi":"10.1016/j.schres.2026.02.012","DOIUrl":"10.1016/j.schres.2026.02.012","url":null,"abstract":"<div><div>Within clinical environments and empirical research, discussions of atypical perceptual experiences (APE; i.e., hallucination) tend to centre on voice-hearing (auditory-verbal hallucinations) in psychotic disorders, with other sensory modalities and psychiatric conditions often neglected. Similarly overlooked are lived experience (LE) perspectives of APE, despite valuable insights that may be gleaned to advance research and clinical practice. The present paper presents a participatory collaboration between a panel of five people with lived experience of APEs and seven APE researchers who worked together on a review of the literature on APEs. LE perspectives were synthesised by researchers with thematic analysis of material generated in five LE consultation sessions held during the course of the project. This revealed six primary themes: (i) challenges during diagnosis and treatment; (ii) what is missing in clinical environments; (iii) underacknowledged cultural and subcultural factors; (iv) stigma; (v) priority areas for developing treatments and; (vi) priority areas for advancing research. Overall, a common sentiment emerged, in that the perception and treatment of APE within the mental health system can often be highly stigmatising, disempowering and distressing. It is hoped that recommendations outlined here may forge more positive and productive treatment experiences for persons distressed by their APE, irrespective of diagnosis.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"292 ","pages":"Pages 12-20"},"PeriodicalIF":3.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147387780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Schizophrenia ResearchPub Date : 2026-06-01Epub Date: 2026-03-04DOI: 10.1016/j.schres.2026.02.019
Wenrui Deng , Michelle N. Servaas , Claire Kos , Jan-Bernard C. Marsman , Remco J. Renken , André Aleman , Marie-José van Tol
{"title":"Motor activity-based prediction of the presence of apathy in schizophrenia","authors":"Wenrui Deng , Michelle N. Servaas , Claire Kos , Jan-Bernard C. Marsman , Remco J. Renken , André Aleman , Marie-José van Tol","doi":"10.1016/j.schres.2026.02.019","DOIUrl":"10.1016/j.schres.2026.02.019","url":null,"abstract":"<div><h3>Objective</h3><div>Apathy, a reduction in self-initiated goal-directed behavior, is a quality-of-life diminishing characteristic of schizophrenia, which often goes underrecognized and undertreated. Actigraphy-derived motor activity measures provide potential objective markers for assessing apathy, but the value for assessing clinically relevant levels of apathy has yet to be determined in patients with schizophrenia.</div></div><div><h3>Methods</h3><div>Patients with schizophrenia with (SZ+; <em>n</em> = 42) and without (SZ−; <em>n</em> = 40) severe apathy symptoms and a group of age and education matched non-affected individuals (NAC; n = 40) were included. Activity indices derived from actigraphy recordings on two weekend days were compared between the three groups. Logistic regression analyses were conducted to examine whether actigraphy indices could predict presence of 1) a diagnosis of schizophrenia and 2) severe apathy.</div></div><div><h3>Results</h3><div>Lower levels and lower variability of activity and step counts during weekend days and the most active ten-hour period were associated with the presence of a schizophrenia diagnosis, and presence of severe apathy within patients. These associations were independent of sociodemographic, lifestyle status and clinical confounders. Backwards regression revealed that mean steps during the most active ten-hour period exhibited the strongest predictor of apathy severity.</div></div><div><h3>Conclusion</h3><div>Results suggest that amount and variability of physical activity as measured with an actigraphy device can help to identify individuals with schizophrenia with high levels of apathy. Especially, the number of steps taken during the most active hours could be used to screen patients with a presence of severe apathy, therefore informing further diagnostics and treatment.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"292 ","pages":"Pages 1-11"},"PeriodicalIF":3.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Schizophrenia ResearchPub Date : 2026-05-01Epub Date: 2026-02-12DOI: 10.1016/j.schres.2026.02.005
Mengdi Jin , Haixin Li , Lijuan Yan , Hongmin Wang , Hongyi Ren , Xiangxiang Zhang , Wenyin Hu , Yihan Hao , Mengtong Xie , Yuqi Yang , Ning Wang , Qiong Yu
{"title":"Radiomics-based prediction of early antipsychotic treatment response for first-episode schizophrenia","authors":"Mengdi Jin , Haixin Li , Lijuan Yan , Hongmin Wang , Hongyi Ren , Xiangxiang Zhang , Wenyin Hu , Yihan Hao , Mengtong Xie , Yuqi Yang , Ning Wang , Qiong Yu","doi":"10.1016/j.schres.2026.02.005","DOIUrl":"10.1016/j.schres.2026.02.005","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to develop and validate cranial CT-based radiomics models for predicting early antipsychotic response in first-episode schizophrenia (SCZ).</div></div><div><h3>Methods</h3><div>We retrospectively enrolled 530 antipsychotic-naïve first-episode SCZ patients and split them 7:3 into training and independent test sets. Early response was defined as ≥25% Brief Psychiatric Rating Scale (BPRS) reduction at week four. CT images were resampled, registered to MNI space, and parcellated using the Harvard–Oxford atlas. Radiomic features (RFs) were extracted and selected via a multi-stage pipeline (ANOVA, mutual information, LASSO–SVM, and interaction screening). An XGBoost classifier was trained to generate radiomics-only predictions. A radiomics score (Rad-Score) was derived by logistic regression and combined with clinical predictors in a nomogram. Spearman's correlations between RFs and symptoms were tested with FDR control.</div></div><div><h3>Results</h3><div>Among the RFs of 530 patients (313 responders and 217 non-responders), we retained 11 radiomic features and one interaction term, predominantly from temporal regions and the thalamus. In the test set, AUCs were 0.72 for the clinical-only model and 0.86 for the radiomics-only model; the nomogram integrating Rad-Score with age, duration of untreated psychosis, marital status, and education achieved AUC = 0.92. Sensitivity analyses using ≥30% and ≥40% response thresholds showed consistent discrimination. Rad-Score correlated with symptom improvement (rs = 0.504; q < 0.001).</div></div><div><h3>Conclusion</h3><div>Baseline cranial CT radiomics, particularly when combined with routine clinical factors, enables accurate early prediction of antipsychotic response and yields interpretable biomarkers linked to symptom change in first-episode schizophrenia.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"291 ","pages":"Pages 1-11"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146154170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Schizophrenia ResearchPub Date : 2026-04-01Epub Date: 2026-02-10DOI: 10.1016/j.schres.2026.02.004
Ryan M. Guest , Jean Addington , Carrie E. Bearden , Kristin S. Cadenhead , Barbara A. Cornblatt , Daniel H. Mathalon , Diana O. Perkins , Ming T. Tsuang , Scott W. Woods , Tyrone D. Cannon , Matcheri S. Keshavan , William S. Stone , Elaine F. Walker
{"title":"Contributions of regional cortical thickness and surface area to cognitive functioning in psychosis-risk","authors":"Ryan M. Guest , Jean Addington , Carrie E. Bearden , Kristin S. Cadenhead , Barbara A. Cornblatt , Daniel H. Mathalon , Diana O. Perkins , Ming T. Tsuang , Scott W. Woods , Tyrone D. Cannon , Matcheri S. Keshavan , William S. Stone , Elaine F. Walker","doi":"10.1016/j.schres.2026.02.004","DOIUrl":"10.1016/j.schres.2026.02.004","url":null,"abstract":"<div><div>Cognitive deficits in schizophrenia are detectable at the onset of illness and during the preceding prodromal period. Additionally, adolescents and young adults at clinical high risk for psychosis (CHR-P) demonstrate cognitive impairment regardless of future conversion. The cortical substrates of these deficits have yet to be established within CHR-P samples, including the differential relations of cortical thickness (CTh) versus surface area (SA) as they differ in underlying cytoarchitecture and genetic influences. Youth at CHR-P (<em>N</em> = 463) and healthy control participants (<em>N</em> = 210) from the second cohort of the North American Prodrome Longitudinal Study (ages 12-35) completed the two-subtest form of the Wechsler Abbreviated Scale of Intelligence and structural MRI scans at baseline. The associations between regional cortical morphometry and Full-Scale IQ (FSIQ-2) were examined using multiple linear regression. Increased CTh in frontoparietal regions (left lateral orbitofrontal cortex; left precentral gyrus; left postcentral gyrus; right supramarginal gyrus) and lateral occipital areas associated with better cognitive functioning in CHR-P. In contrast, among healthy control participants, no associations between CTh and cognitive functioning were observed. Additionally, increased SA across the cortex was associated with better cognitive functioning for both groups, though people at CHR-P demonstrated a more diffuse pattern of associations. These results underscore the importance of decomposing cortical volume into CTh and SA and how variation in cognitive functioning may be potentially supported by shared and group-specific substrates. Results generate hypotheses about how aberrant neurodevelopmental processes, such as cortical thinning, may disturb cognitive functioning in the early stage of psychosis.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"290 ","pages":"Pages 98-105"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Schizophrenia ResearchPub Date : 2026-04-01Epub Date: 2026-02-06DOI: 10.1016/j.schres.2026.01.024
Christy Lai Ming Hui , Wing Chung Chang , Evie Wai Ting Chan , Yi Nam Suen , Edwin Ho Ming Lee , Sherry Kit Wa Chan , Eric Yu Hai Chen
{"title":"The effects of extended early intervention services on clinical and functional outcomes in first-episode psychosis","authors":"Christy Lai Ming Hui , Wing Chung Chang , Evie Wai Ting Chan , Yi Nam Suen , Edwin Ho Ming Lee , Sherry Kit Wa Chan , Eric Yu Hai Chen","doi":"10.1016/j.schres.2026.01.024","DOIUrl":"10.1016/j.schres.2026.01.024","url":null,"abstract":"<div><h3>Background</h3><div>This study examined the functional and clinical effects of extending Early Intervention Service (EIS) for individuals with first-episode psychosis (FEP) by one additional year, compared with transitioning to standard care (SC) after completing two years of EIS. Age and duration of untreated psychosis (DUP) were explored as potential moderators across a broad age range (15–55 years).</div></div><div><h3>Methods</h3><div>Secondary analyses were conducted on two randomised controlled trials involving 400 FEP patients who had completed two years of EIS (extended EIS: <em>n</em> = 202; SC: <em>n</em> = 198). Participants were assessed at two years and again at three years. Multiple linear regression and mixed-effects models were used to evaluate treatment effects and the moderating roles of age (<25 vs ≥25 years) and DUP (<92 vs. ≥92 days).</div></div><div><h3>Results</h3><div>Extended EIS improved functioning relative to SC, including higher employment rates (<em>p</em> = 0.024), increased Role Functioning Scale (RFS) total and subdomain scores (<em>p</em> < 0.001 to 0.015), and better Social and Occupational Functioning Assessment Scale (SOFAS) scores (<em>p</em> < 0.001). Short DUP was associated with greater gains in certain RFS subdomains (<em>p</em> = 0.003 to 0.008) and SOFAS (<em>p</em> < 0.001). Younger patients showed greater improvements in RFS independent living and self-care (<em>p</em> = 0.019), and reductions in overall symptom severity (<em>p</em> = 0.014) and general psychopathology (<em>p</em> = 0.020).</div></div><div><h3>Conclusions</h3><div>A one-year extension of EIS produced additional functional benefits, with stronger effects observed among younger patients and those with shorter DUP. Extending EIS for individuals who continue to demonstrate functional or clinical difficulties after the initial two-year programme may help optimise long-term recovery and guide efficient service planning.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"290 ","pages":"Pages 73-83"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Schizophrenia ResearchPub Date : 2026-04-01Epub Date: 2026-02-10DOI: 10.1016/j.schres.2025.12.017
P. Do Lan , A.M. Isvoranu , B. Kleim , K. Heekeren , Rössler Wulf , A. Theodoridou
{"title":"Resilience factors and their role in clinical high-risk for psychosis","authors":"P. Do Lan , A.M. Isvoranu , B. Kleim , K. Heekeren , Rössler Wulf , A. Theodoridou","doi":"10.1016/j.schres.2025.12.017","DOIUrl":"10.1016/j.schres.2025.12.017","url":null,"abstract":"<div><h3>Objective</h3><div>Recent approaches in psychosis research have emphasized the importance of the combined analysis of risk and resilience factors. A resilience-integrated approach offers a more comprehensive understanding of the mechanisms underlying symptom associations and progression in individuals at clinical high-risk (CHR) for psychosis. Network analysis allows the examination of relationships among mental health conditions together with both risk and resilience factors. To our knowledge, this is the first study that investigated associations between resilience, risk factors, and psychosis-risk using network analysis.</div></div><div><h3>Methods</h3><div>This secondary analysis of data from the ZInEP study (Zurich Early Recognition Program) examined 116 individuals at CHR for psychosis aged 18–35 years. We investigated the relationships between two candidate resilience factors (self-efficacy and self-esteem), daily hassles as a candidate risk factor, functioning level, and psychosis risk symptoms using network analysis.</div></div><div><h3>Results</h3><div>Self-esteem and self-efficacy were negatively associated with general symptoms, negative symptoms, and daily hassles. Resilience factors and daily hassles were not associated with positive and disorganized symptoms, nor with functioning level. Centrality analyses further revealed that self-esteem had stronger node strength and bridge strength than self-efficacy.</div></div><div><h3>Conclusions</h3><div>This study emphasizes the utility of a resilience-oriented approach in psychosis risk. Self-esteem and self-efficacy may play a crucial role in negative and general symptoms. Resilience factors may enrich our theoretical understanding of psychosis risk and help pave the way for resilience-based interventions.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"290 ","pages":"Pages 106-113"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Schizophrenia ResearchPub Date : 2026-04-01Epub Date: 2026-02-10DOI: 10.1016/j.schres.2026.02.001
Deepa Purushothaman , Sümeyra N. Tayfur , Zhiqian Song , Fangyong Li , Silvia Corbera , Laura Yoviene Sykes , Sarah Riley , Javier Ponce Terashima , Deepak Cyril D'Souza , Cenk Tek , Vinod H. Srihari
{"title":"Changes in cannabis use following legalization: Effects in first-episode psychosis","authors":"Deepa Purushothaman , Sümeyra N. Tayfur , Zhiqian Song , Fangyong Li , Silvia Corbera , Laura Yoviene Sykes , Sarah Riley , Javier Ponce Terashima , Deepak Cyril D'Souza , Cenk Tek , Vinod H. Srihari","doi":"10.1016/j.schres.2026.02.001","DOIUrl":"10.1016/j.schres.2026.02.001","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"290 ","pages":"Pages 86-87"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}