Schizophrenia Research最新文献

{"title":"Effects of visual remediation on Ebbinghaus illusion task performance in people with schizophrenia: A preliminary study","authors":"Kaitlyn A. Kaiser ,&nbsp;Judy L. Thompson ,&nbsp;Pamela D. Butler ,&nbsp;Anthony O. Ahmed ,&nbsp;Aaron R. Seitz ,&nbsp;Tarek Sobeih ,&nbsp;Steven M. Silverstein","doi":"10.1016/j.schres.2025.02.011","DOIUrl":"10.1016/j.schres.2025.02.011","url":null,"abstract":"<div><h3>Background</h3><div>Atypical perception of visual illusions is well-documented in schizophrenia (SZ) and thought to be a consequence of impairments in visual processes including perceptual organization (PO). The Ebbinghaus illusion, in which a circle appears larger or smaller depending on the size of surrounding circles, is facilitated by PO, and the extent to which the surrounds (i.e., context) influence perception of the center circle can be considered an index of <em>context sensitivity</em>. In the present study, as part of a broader investigation of the impact of a novel visual remediation (VR) program for people with SZ, the Ebbinghaus illusion was used to explore the effects of VR on context sensitivity.</div></div><div><h3>Methods</h3><div>Participants with SZ (<em>n</em> = 47) were randomly assigned to one of four conditions: VR only, an active control condition (AC), or one of two conditions combining VR and AC. At three assessment points, participants completed a size comparison task based on the Ebbinghaus illusion. Context sensitivity was compared between training groups and with baseline clinical characteristics.</div></div><div><h3>Results</h3><div>At baseline, participants were strongly context sensitive. After training, participants in the VR group, but not the AC-only group, became less influenced by context. The main effect of training group and the group × time interaction terms were not significant. Participants who were less symptomatic at baseline showed the greatest reductions in context sensitivity over time.</div></div><div><h3>Conclusions</h3><div>These findings suggest that an adaptive reduction in the influence of irrelevant context is a potential effect of VR and may reflect improved attentional focus.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 57-64"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clinical symptoms and symptom structure across different onset ages in schizophrenia inpatients","authors":"Zhaofan Liu ,&nbsp;Xiaoying Wang ,&nbsp;Wenjin Chen ,&nbsp;Junchao Huang ,&nbsp;Jinghui Tong ,&nbsp;Jue Wang ,&nbsp;Ran Liu ,&nbsp;Hu Deng ,&nbsp;Kebing Yang ,&nbsp;Wei Li ,&nbsp;Song Chen ,&nbsp;Ting Xie ,&nbsp;Li Tian ,&nbsp;Fude Yang ,&nbsp;Baopeng Tian ,&nbsp;Yanli Li ,&nbsp;Chiang-Shan R. Li ,&nbsp;Yunlong Tan","doi":"10.1016/j.schres.2025.03.015","DOIUrl":"10.1016/j.schres.2025.03.015","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to explore differences in clinical symptom profiles and symptom network structures of inpatients with schizophrenia among early-onset schizophrenia (EOS), typical-onset schizophrenia (TOS), and late-onset schizophrenia (LOS) patients.</div></div><div><h3>Methods</h3><div>Symptom severity was assessed using the Positive and Negative Syndrome Scale (PANSS) in 654 EOS, 1664 TOS, and 369 LOS inpatients with schizophrenia from an open dataset. Symptom severity comparisons were conducted among the three age of onset groups. Symptom networks were constructed, and measurements such as betweenness and closeness centrality were employed to investigate the interconnectivity between symptoms.</div></div><div><h3>Results</h3><div>EOS inpatients exhibited significantly more severe symptoms compared to TOS and LOS, primarily attributable to more severe negative symptoms and general psychopathology. Analysis of the symptom networks revealed that uncontrolled hostility emerged as a core feature across EOS, TOS, and LOS. In the EOS network, anxiety domain served as bridge symptoms, while positive and disorganized thought were strongly associated with disease manifestations. TOS inpatients exhibited a similar pattern to EOS, but TOS showed higher betweenness and lower closeness in positive and negative symptoms, indicating that these domains play a crucial role in the overall network connectivity. In LOS, positive symptoms showed high betweenness centrality, suggesting their pivotal role in network connectivity.</div></div><div><h3>Conclusions</h3><div>These findings suggest that the symptom severity and symptoms network structure differ across different age of onset groups in schizophrenia inpatients. A deeper understanding of these network-level differences could shed light on the distinct pathogenesis mechanisms and guide the development of personalized treatment strategies for schizophrenia.</div></div><div><h3>Hypothesis</h3><div>It has been consistently observed that inpatients with early-onset schizophrenia (EOS) have poorer treatment outcomes compared to typical-onset schizophrenia patients (TOS), while those with late-onset schizophrenia (LOS) tend to have better outcomes than typical-onset inpatients. The reasons behind these phenomena remain unclear. In this work, we aim to utilize network analysis to uncover potential symptom interactions that may contribute to the different treatment outcomes observed across different ages of onset schizophrenia inpatient groups.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 177-184"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of tDCS with concurrent cognitive performance targeting the dorsolateral prefrontal cortex and the posterior parietal cortex on EEG microstates in schizophrenia","authors":"Xiangqin Qin ,&nbsp;Qi Wang ,&nbsp;Hang Li ,&nbsp;Jingkun Wang ,&nbsp;Zhen Mao ,&nbsp;Fang Dong ,&nbsp;Qijing Bo ,&nbsp;Fuchun Zhou ,&nbsp;Xianbin Li ,&nbsp;Wenpeng Hou ,&nbsp;Chuanyue Wang","doi":"10.1016/j.schres.2025.03.003","DOIUrl":"10.1016/j.schres.2025.03.003","url":null,"abstract":"<div><h3>Objectives</h3><div>Working memory impairments represent fundamental cognitive deficits in schizophrenia (SZ). Although transcranial direct current stimulation (tDCS) has demonstrated potential in enhancing working memory in SZ, its neural mechanisms and optimized strategies remain to be elucidated. This study explored the effects of tDCS with concurrent cognitive performance targeting the dorsolateral prefrontal cortex (DLPFC) and posterior parietal cortex (PPC) on electroencephalography (EEG) microstates in SZ.</div></div><div><h3>Methods</h3><div>This analysis is based on a randomized, double-blind clinical trial of tDCS with concurrent cognitive performance in SZ. Sixty participants were assigned to three groups: active DLPFC, active PPC, and sham stimulation groups. tDCS was administered concurrently with a visual working memory task. The spatial span test was used to assess working memory at baseline, week 1, and week 2, with resting-state EEG data collected at each time point.</div></div><div><h3>Results</h3><div>No significant differences were detected in the characteristics of the four microstates (A, B, C, and D) at baseline. Compared with the sham stimulation group, the active DLPFC and PPC groups exhibited significant improvements in the duration, occurrence, and coverage of microstate B at week 2. However, the changes in the parameters of microstate B at week 2 were not significantly correlated with working memory improvement.</div></div><div><h3>Conclusions</h3><div>This study suggests that neuromodulation targeting different nodes within the task-induced network may influence the same subnetworks in SZ. This work provides new insights into network-based interventions and contributes to the development of multitarget intervention strategies under task conditions.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 117-123"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI data sharing in psychosis: Key challenges and a new Open Access resource for researchers","authors":"S.L. Evans ,&nbsp;V. Kumari ,&nbsp;M.J. Kempton ,&nbsp;J. Rogers ,&nbsp;R. Upthegrove ,&nbsp;P. Allen","doi":"10.1016/j.schres.2025.03.012","DOIUrl":"10.1016/j.schres.2025.03.012","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 185-187"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of integrated social cognitive remediation vs neurocognitive remediation in schizophrenia: Results from the multicenter randomized controlled ISST (Integrated Social Cognition And Social Skills Therapy) study","authors":"Daniel Kamp ,&nbsp;Agnes Lowe ,&nbsp;Karolin Weide ,&nbsp;Mathias Riesbeck ,&nbsp;Andreas Bechdolf ,&nbsp;Karolina Leopold ,&nbsp;Anke Brockhaus-Dumke ,&nbsp;Bettina Klos ,&nbsp;René Hurlemann ,&nbsp;Sven Wasserthal ,&nbsp;Ana Muthesius ,&nbsp;Joseph Kambeitz ,&nbsp;Stefan Klingberg ,&nbsp;Lea Hölz ,&nbsp;Martin Hellmich ,&nbsp;Kerstin D. Rosenberger ,&nbsp;Sabine Sadura ,&nbsp;Andreas Meyer-Lindenberg ,&nbsp;Wolfgang Wölwer","doi":"10.1016/j.schres.2025.02.015","DOIUrl":"10.1016/j.schres.2025.02.015","url":null,"abstract":"<div><h3>Introduction</h3><div>Persistent poor psychosocial functioning, which is associated with impairments in cognition, is one of the main barriers to recovery in schizophrenia. Although cognitive remediation therapy (CRT) has shown general efficacy in improving cognition and functioning, simultaneously focusing on social cognition and social behavioural processes may increase its efficacy.</div></div><div><h3>Methods</h3><div>In a multicenter, rater-blinded, randomized controlled trial, schizophrenia patients (N = 177) were assigned to six months of either Integrated Social Cognitive and Behavioral Skills Therapy (ISST) or, as an active control intervention, Neurocognitive Remediation Therapy (NCRT). The primary endpoint was all-cause discontinuation (ACD) over the 12-month study period. Secondary endpoints were cognition, psychosocial functioning and quality of life, and clinical symptoms.</div></div><div><h3>Results</h3><div>ACD was not significantly different between the ISST and NCRT groups (43.3 % vs 34.5 %, respectively). More improvement was seen in social cognition (Pictures of Facial Affect; d = 0.83) in the ISST group and in neurocognition (subscores of the Auditory Verbal Learning Test; d = 0.29–0.40) in the NCRT group. Level of functioning, quality of life, and clinical symptoms significantly improved in both groups, with no significant between-group differences.</div></div><div><h3>Discussion</h3><div>Both therapies differentially improved measures of the cognitive domains they were designed for. Moreover, they both improved social functioning with high effect sizes (d = 0.8–1.0), underlining the important role of CRT in recovery-oriented schizophrenia treatment. However, the absence of a third group without an active intervention limits the interpretability of the results.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 44-56"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling distinct representations of P3a in schizophrenia through two-stimulus and three-stimulus auditory oddball paradigms","authors":"Chenguang Jiang ,&nbsp;Jun Wang ,&nbsp;Yifan Sun ,&nbsp;Shuping Tan ,&nbsp;Shaun M. Percell ,&nbsp;the GRINS consortium,&nbsp;Zhenhe Zhou ,&nbsp;Jen Q. Pan ,&nbsp;Mei-Hua Hall","doi":"10.1016/j.schres.2025.03.004","DOIUrl":"10.1016/j.schres.2025.03.004","url":null,"abstract":"<div><h3>Background</h3><div>P3a event-related potential (ERP) is considered a potential biomarker for schizophrenia (SZ), can be elicited through both passive two-stimulus and active three-stimulus auditory oddball paradigms. While both types of P3a reflect involuntary attention shifts, the nuanced understanding of what P3a represents in different contexts is important and rarely studied. This study aims to examine correlations between P3a ERPs elicited from different paradigms and associations of each P3a with cognitive function, clinical symptoms, and antipsychotic medication.</div></div><div><h3>Methods</h3><div>Our sample included 178 SZ patients and 127 healthy controls (HC). Data on two-stimulus paradigm, three-stimulus oddball paradigm, Chinese version of MATRICS Consensus Cognitive Battery (MCCB), symptom severity, and medication use were collected.</div></div><div><h3>Results</h3><div>In both paradigms, SZ group's P3a amplitude was significantly reduced compared to HC's (both <em>p</em> &lt; 0.05). P3a evoked by the two-stimulus paradigm and the three-stimulus paradigm were not correlated (<em>r</em> = −0.06, <em>p</em> = 0.661). Three-stimulus paradigm-P3a was significantly correlated with attention/vigilance (<em>r</em> = 0.27, <em>p</em> = 0.017) in SZ, and with working memory (<em>r</em> = 0.39, <em>p</em> = 0.001) and overall MCCB score (<em>r</em> = 0.25, <em>p</em> = 0.042) in HC. Additionally, the two-stimulus paradigm-P3a correlated with olanzapine equivalent antipsychotic dose (<em>r</em> = −0.26, <em>p</em> = 0.022).</div></div><div><h3>Conclusions</h3><div>Our findings offer new insights into the role of P3a in clinical research. P3a ERPs from different paradigms may represent functionally distinct components. The context in which the P3a is elicited should be taken into account when discussing its functional or neurocognitive significance.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 159-168"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manual dexterity and grip force are distinctly linked to domains of neurological soft signs in schizophrenia spectrum disorders","authors":"Sofie von Känel ,&nbsp;Anastasia Pavlidou ,&nbsp;Niluja Nadesalingam ,&nbsp;Victoria Chapellier ,&nbsp;Melanie G. Nuoffer ,&nbsp;Alexandra Kyrou ,&nbsp;Lydia Maderthaner ,&nbsp;Florian Wüthrich ,&nbsp;Stephanie Lefebvre ,&nbsp;Sebastian Walther","doi":"10.1016/j.schres.2025.02.010","DOIUrl":"10.1016/j.schres.2025.02.010","url":null,"abstract":"<div><div>Motor abnormalities are highly prevalent among patients with schizophrenia spectrum disorders. Very likely, motor control processes, such as dexterity and grip force (GF), are impaired in schizophrenia. We aimed to explore associations between various motor abnormalities and motor control processes and to investigate whether specific motor abnormalities predict the performance of fine motor movements and GF.</div><div>Our analyses included 198 patients with schizophrenia spectrum disorders. We applied well-established standardized motor rating scales to assess five different motor abnormalities: psychomotor slowing (PS), neurological soft signs (NSS), parkinsonism, catatonia, and dyskinesia. As a measure of manual dexterity, we used the coin rotation (CR) task, requiring patients to rotate a coin between their thumb, index, and middle finger. Maximal grip strength was measured with the GF task.</div><div>Correlation analyses revealed that both CR and GF performances were associated with different motor abnormalities, most strongly with NSS (CR: tau = −0.263, <em>p</em> &lt; 0.001; GF: tau = −0.208, p &lt; 0.001). Hierarchical regression showed that NSS predicted performance on the CR and GF task better compared to PS, parkinsonism, and catatonia alone (CR: ∆R² = 0.09, F = 22.26, <em>p</em> &lt; 0.001; GF: ∆R² = 0.02, F = 6.61, p &lt; 0.001). When looking within the NSS domains, CR performance was predicted better by motor coordination and sequencing of motor acts, whereas GF was predicted better by sensory integration.</div><div>Motor control processes are influenced by different motor abnormalities, especially NSS. Our results suggest that distinct aspects of NSS affect fine motor movements and GF. This knowledge is important for designing specific novel interventions aimed at improving specific motor control processes.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 65-73"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences and age of onset in well-being and recovery in people with psychotic disorders. A PHAMOUS study","authors":"Linda Hoeksema ,&nbsp;Jojanneke Bruins ,&nbsp;Marieke E. Timmerman ,&nbsp;Stynke Castelein","doi":"10.1016/j.schres.2025.01.029","DOIUrl":"10.1016/j.schres.2025.01.029","url":null,"abstract":"<div><h3>Purpose</h3><div>Women generally have a later age of onset, and may therefore have a more favourable course of psychotic illness than men regarding psychopathology. Little is known about a broader range of outcomes, including well-being and recovery, and about the influence of age of onset. This study examines longitudinal sex-related and age of onset-related differences in well-being and recovery of people with a psychotic disorder with long illness durations.</div></div><div><h3>Methods</h3><div>Routine outcome monitoring data (2012−2021) of n = 3843 patients were used. Well-being (quality of life and personal recovery) and recovery (clinical and societal recovery and psychosocial functioning) were assessed. Latent class growth analysis (LCGA) was performed to assess whether classes with different trajectories of well-being and recovery could be identified. Classes were related to sex and (early/late) age of onset of psychosis (EOP/LOP).</div></div><div><h3>Results</h3><div>LCGA identified five classes with varying combinations in levels of well-being and recovery, which were stable over time. Sex, age of onset and the combination of these two were significantly related to class membership. Women and individuals with LOP were more prevalent in better functioning classes than men and individuals with EOP.</div></div><div><h3>Conclusion</h3><div>This study showed sex differences in long-term recovery patterns of psychosis. Not only women but also individuals with LOP had a higher chance of better well-being and recovery, while men with EOP were at risk for worse outcomes. Taking these sex differences into account when deciding on policy and treatment protocols for individual patients might provide better mental health care to people with psychosis.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 86-92"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building a two-state learning healthcare system for persons with first episode psychosis","authors":"Jill A. Marsteller ,&nbsp;Richard W. Goldberg ,&nbsp;Yasmine Boumaiz ,&nbsp;Megan B.E. Jumper ,&nbsp;Jessica Taylor ,&nbsp;Arunadevi Saravana ,&nbsp;Robert W. Buchanan ,&nbsp;K.N. Roy Chengappa ,&nbsp;Catherine G. Conroy ,&nbsp;Faith Dickerson ,&nbsp;Arielle Ered ,&nbsp;Nev Jones ,&nbsp;Christian G. Kohler ,&nbsp;Julie Kreyenbuhl ,&nbsp;Alicia Lucksted ,&nbsp;Russell L. Margolis ,&nbsp;Deborah Medoff ,&nbsp;Peter Phalen ,&nbsp;Deepak K. Sarpal ,&nbsp;William R. Smith ,&nbsp;Melanie E. Bennett","doi":"10.1016/j.schres.2025.02.004","DOIUrl":"10.1016/j.schres.2025.02.004","url":null,"abstract":"<div><div>The Connection Learning Healthcare System (CLHS) represents a network of academic institutions, state behavioral health systems, and early psychosis specialty care programs in Pennsylvania and Maryland working together to provide the best evidence-based care for persons with first episode psychosis. Developing an integrated, two-state system required unification and harmonization of data collection, training, consultation, research, and dissemination activities. Here we describe the model that supported these efforts and our experience creating an active two-state learning healthcare system. We also review areas of ongoing attention and offer lessons learned.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 74-85"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of long-acting injectable antipsychotics in early psychosis: An umbrella review","authors":"Marie Etienne ,&nbsp;Hélène Verdoux","doi":"10.1016/j.schres.2025.03.002","DOIUrl":"10.1016/j.schres.2025.03.002","url":null,"abstract":"<div><h3>Objectives</h3><div>There is still no consensus regarding the indications of long-acting injectable antipsychotics (LAIs) in early psychosis (EP). This umbrella review synthesizes findings from systematic reviews and meta-analyses on the risk-benefit balance of LAIs in EP.</div></div><div><h3>Methods</h3><div>Eligible systematic reviews and meta-analyses on LAIs in EP were identified by a MEDLINE search from inception until June 2024. Data were synthesized narratively.</div></div><div><h3>Results</h3><div>Seven systematic reviews and four meta-analyses published from 2007 to 2024 were identified. They included 220 to 14,313 participants recruited in 58 primary unique randomized controlled trials or observational studies. All LAIs were considered in most reviews. Inclusion criteria and diagnoses differed widely across the selected reviews. The reviews and meta-analyses consistently showed a positive impact of LAIs on symptomatic outcome in people with EP, although there was no consensus on whether LAIs outperformed oral anti-psychotics (OAPs). Most reported a greater reduction of treatment discontinuation due to inefficacy or nonadherence with LAIs vs. OAPs, although meta-analyses found no difference between LAIs vs. OAPs regarding all-cause discontinuation. Findings regarding relapse prevention were inconclusive. Similar rates of metabolic adverse drug reaction and potentially lower rates of extrapyramidal symptoms were observed with LAIs vs. OAPs.</div></div><div><h3>Conclusion</h3><div>LAIs should be considered according to users' preferences and could be particularly useful for people with a poor medication adherence risk profile. Further high-quality observational studies in real-life prescribing conditions are needed to support robust recommendations for clinical practice regarding indications of LAIs in EP.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 140-150"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}