Schizophrenia Research最新文献

{"title":"Issue highlights","authors":"","doi":"10.1016/S0920-9964(25)00170-7","DOIUrl":"10.1016/S0920-9964(25)00170-7","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Page A1"},"PeriodicalIF":3.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood-level social determinants of suicidality in youth with schizophrenia: An EHR-based study","authors":"Jeonghyun Shin ,&nbsp;Jialin Wu ,&nbsp;Hyun Jung Kim ,&nbsp;Wenna Xi","doi":"10.1016/j.schres.2025.04.035","DOIUrl":"10.1016/j.schres.2025.04.035","url":null,"abstract":"<div><h3>Background</h3><div>Suicidal thoughts and behaviors (STB) among youth with schizophrenia represent a significant public health concern. It is well-established that neighborhood-level social determinants of health (SDoHs) can impact health outcomes in individuals with schizophrenia. We aimed to investigate the effects of neighborhood-level social determinants on developing future STB in youth with schizophrenia.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study using electronic health records from the INSIGHT Clinical Research Network, which contains &gt;22 million unique patients across five healthcare systems in New York City. Patients' neighborhood-level SDoHs were measured at their residential ZIP Code Tabulation Area using a composite measure, Social Deprivation Index (SDI), as well as specific components derived from the American Community Survey. Survival analysis was used to study the association between neighborhood-level SDoHs and time to STB since the first schizophrenia diagnosis.</div></div><div><h3>Results</h3><div>Between 10/1/2015 and 10/1/2022, we identified 1209 youth aged between 10 and 25 years with a schizophrenia diagnosis and no prior STB, among whom 176 developed STB during follow-up. SDI quintiles were not associated with the risk of future STB, whereas two specific neighborhood characteristics, Gini index and percentage of residents commuting by car/truck/van, were associated with a decreased risk of STB, after controlling for patients' demographic characteristics.</div></div><div><h3>Conclusions</h3><div>Although the overall neighborhood deprivation level was not associated with the risk of STB among youth with schizophrenia, specific neighborhood characteristics were. These findings underscore the need for more targeted community-based suicide prevention strategies. Further research is essential to better understand the underlying mechanism of these associations.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 74-81"},"PeriodicalIF":3.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediterranean and standard American diet consumption in psychosis and non-psychosis affective disorders groups: Symptoms and cognition","authors":"Lauren R. Koralnik ,&nbsp;Ezequiel Lafont ,&nbsp;Christa Akerele ,&nbsp;Mharisi Bonner ,&nbsp;Audrey Musselman ,&nbsp;Eugene Ruby ,&nbsp;Oded Gonen ,&nbsp;Eyal Lotan ,&nbsp;Jakleen Lee ,&nbsp;Jose C. Clemente ,&nbsp;Jessica Robinson-Papp ,&nbsp;Judith Weissman ,&nbsp;Julie Walsh-Messinger ,&nbsp;Dolores Malaspina","doi":"10.1016/j.schres.2025.04.025","DOIUrl":"10.1016/j.schres.2025.04.025","url":null,"abstract":"<div><div>Research supports an association between diet and health, and emerging evidence suggests that diet is associated with neuropsychiatric symptoms. However, no human study has examined an anti-inflammatory diet across rigorously defined psychiatric diagnoses and its associations with symptom severity and cognition. As inflammation is implicated in mental illness, we investigated adherence to the Mediterranean diet (MD), an anti-inflammatory diet, and the standard American diet (SAD), and examined cross-sectional relationships with psychiatric symptoms and cognition. Method: Participants included 54 individuals with psychotic disorders, 30 with non-psychosis affective disorders and 40 healthy controls. Participants underwent diagnostic interviews, PANSS symptom ratings, and MATRICS cognitive assessments. The self-report GBAQ was used to assess adherence to the MD versus SAD. Results: The psychosis group was significantly more likely to consume the SAD than healthy controls (p = 0.007), with MD adherence predicting better working memory (r = 0.461, p &lt; 0.001). In the non-psychosis affective disorders group, MD adherence predicted slower processing speed (r = -0.376, p = 0.049). In the non-psychosis affective disorders group, MD predicted reduced PANSS General Psychopathology scale (r = -0.449, p = 0.013), as well as the Activation (r = -0.362, p = 0.049), and Dysphoric Mood factors (r = -0.403, p = 0.027).Discussion: This first-of-its kind study identified poor dietary choices in persons with psychosis, showing significantly lower symptoms and better cognition in association with the MD in transdiagnostic analyses. It supports the study of dietary interventions for prevention and treatment of psychiatric conditions.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 60-73"},"PeriodicalIF":3.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital phenotyping evidence for the reduced positivity offset as a mechanism underlying anhedonia among individuals at clinical high-risk for psychosis","authors":"Lisa A. Bartolomeo ,&nbsp;Sydney H. James ,&nbsp;Alysia M. Berglund ,&nbsp;Ian M. Raugh ,&nbsp;Vijay A. Mittal ,&nbsp;Elaine F. Walker ,&nbsp;Gregory P. Strauss","doi":"10.1016/j.schres.2025.04.029","DOIUrl":"10.1016/j.schres.2025.04.029","url":null,"abstract":"<div><div>Prior studies suggest that the “anhedonia paradox” in schizophrenia (i.e., discrepant results indicating intact hedonic reactivity despite reduced frequency of pleasure-seeking activity) can be explained by a reduction in the “positivity offset” (i.e., a reduction in the normative tendency to experience greater positive than negative affect during low arousal neutral contexts that promote reward-seeking behavior). In the current study, we examined whether the positivity offset is relevant to explaining anhedonia and liability for psychosis among individuals at clinical high-risk for psychosis (CHR) (i.e., individuals exhibiting attenuated hallucinations or delusions that cause distress and functional decline). Mathematical modeling approaches from Cacioppo’s Evaluative Space Model were applied to six days of digital phenotyping data collected in daily life among 100 individuals at CHR and 57 healthy controls (CN). Participants reported levels of positive emotion, negative emotion, and arousal throughout the day via ecological momentary assessment (EMA) surveys while accelerometry was passively recorded. EMA surveys were used to calculate the positivity offset and examine associations with real-world motivated behavior. Results indicated that the positivity offset was present among individuals at CHR, but diminished compared to CN. Importantly, smaller positivity offset scores were associated with greater clinically rated anhedonia, particularly among CHR cases with comorbid mood disorder diagnoses. Findings suggest that reductions in the positivity offset are a mechanism underlying anhedonia across phases of psychotic illness and represent a novel treatment target that is relevant for the treatment of negative symptoms and prevention of psychotic disorders.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 45-51"},"PeriodicalIF":3.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood trauma associations with changes in body mass index over 12 months of treatment in first-episode schizophrenia spectrum disorders","authors":"H.K. Luckhoff,&nbsp;A.M. Smit,&nbsp;L. Phahladira,&nbsp;S. Kilian,&nbsp;R. Emsley,&nbsp;L. Asmal","doi":"10.1016/j.schres.2025.04.031","DOIUrl":"10.1016/j.schres.2025.04.031","url":null,"abstract":"<div><h3>Background</h3><div>Childhood trauma (CT) is a risk factor for the development of adulthood obesity, both in the general population, and in patients with schizophrenia.</div></div><div><h3>Aim</h3><div>We examined the associations between CT exposure and visit-wise changes in body mass index (BMI) over 12 months of treatment in patents with first-episode schizophrenia spectrum disorders (FES) (<em>n</em> = 77) compared to matched controls (<em>n</em> = 55). We also examined the moderating effects of socio-demographic, clinical, and treatment-related factors on the relationships between CT exposure and weight gain in patients.</div></div><div><h3>Methods</h3><div>CT was assessed using the Childhood Trauma Questionnaire. BMI was assessed at baseline in patients and controls and again at regular 3-month intervals in patients. Linear mixed effect models for continuous repeated measures (MMRM) were constructed to examine the effects of CT exposure on visit-wise changes in BMI over time.</div></div><div><h3>Results</h3><div>Patients had a lower baseline BMI than controls, but were balanced for CT exposure. In patients, but not in controls, more severe childhood emotional abuse (EA) correlated with a higher baseline BMI. Initial MMRM indicated that higher childhood EA was associated with more pronounced weight gain over 12 months in patients. Explorative MMRM indicated that this effect was limited to cannabis non-users, and no longer significant in cannabis users.</div></div><div><h3>Discussion</h3><div>Cannabis use moderated the association between childhood EA and more pronounced weight gain in FES. Future studies would do well to examine the effects of other risk and resilience factors on the relationships between CT exposure and metabolic syndrome changes in schizophrenia.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 52-59"},"PeriodicalIF":3.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition and brain health: Implications of Mediterranean diet elements for psychiatric disorders","authors":"Christa A. Akerele ,&nbsp;Lauren R. Koralnik ,&nbsp;Ezequiel Lafont ,&nbsp;Caitlin Gilman ,&nbsp;Julie Walsh-Messinger ,&nbsp;Dolores Malaspina","doi":"10.1016/j.schres.2025.04.026","DOIUrl":"10.1016/j.schres.2025.04.026","url":null,"abstract":"<div><div>The Mediterranean diet is an anti-inflammatory diet now recognized for prevention and intervention against cardiometabolic disorders, although emerging literature also shows its benefits for mental health. This paper surveys literature pertinent to the Mediterranean diet with respect to schizophrenia, bipolar and unipolar depression and cognition. The National Library of Medicine database of literature was searched for publications relating to our topic through June 2024. Our results highlight the Mediterranean diet’s potential role in mediating inflammation, potentially through the gut-brain axis, and its neuroprotective role against cognitive decline. Moreover, individual components of the Mediterranean diet are potentially therapeutic as well as protective, particularly fruits, vegetables, fatty fish, and whole grains. These dietary components reduce systemic inflammation, modulate gut microbiota and influence critical pathways such as moderating oxidative stress. Overall, this survey of recent literature highlights the potential of the Mediterranean diet to promote mental health and reduce the risk or severity of psychiatric and neurodegenerative disorders. The analysis underscores broader implications for the Mediterranean diet in advancing mental health outcomes and emphasizes the need for further studies and increased public education to encourage healthier eating habits and dietary interventions.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 30-44"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive transcriptome analysis and lncRNA-miRNA-mRNA establishment of schizophrenia based on induced pluripotent stem cells","authors":"Ningning Jia ,&nbsp;Xuyuan Yin ,&nbsp;Zhenhua Zhu ,&nbsp;Wenlong Hou ,&nbsp;Qing Yang ,&nbsp;Hongliang Zhu ,&nbsp;Huiping Zhang ,&nbsp;Xin Yu ,&nbsp;Qiong Yu ,&nbsp;Li Hui","doi":"10.1016/j.schres.2025.04.027","DOIUrl":"10.1016/j.schres.2025.04.027","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia (SCZ) is a complex and heterogeneous disorder with unclear underlying mechanisms. Identifying key gene diseases and constructing biological regulatory networks were beneficial in expanding our understanding of the pathogenesis of SCZ.</div></div><div><h3>Methods</h3><div>We conducted whole transcriptome sequencing of induced pluripotent stem cells (iPSCs) derived from 5 SCZ patients and 5 healthy controls to analyze differences in mRNA and non-coding RNA expression profiles. Differentially expressed mRNAs (DE mRNAs) were explored for their functions and pathways, and lncRNA-miRNA-mRNA regulatory networks were constructed to understand post-transcriptional regulation mechanisms. Additionally, correlation analyses between competitive endogenous RNAs (ceRNAs), hub genes, and clinical phenotypes of SCZ patients (positive/negative and cognitive symptoms) were performed.</div></div><div><h3>Results</h3><div>We identified 139 DE mRNAs, 154 lncRNAs, and 19 miRNAs. Significant enrichment of pathways related to apoptosis, inflammatory response, hypoxia, KRAS signaling, and IL6_JAK_STAT3 signaling were observed. Ten hub genes, CCK, CCNA1, CDH5, GATA2, GRPR, NPY, PRKG2, TLE6, ZEB1and ZEB2, were identified, of which ZEB1 and GATA2 were positively correlated with positive symptoms of SCZ, while CDH5 and GRPR were associated with memory. The ceRNA regulatory network (TPM1-AS/ADPGK-AS1/MIRLET7BHG-hsa-mir-3180/3180-3p-LRRC15/TUBA8 and MIRLET7BHG- hsa-mir-3187-3p- CCDC92/ TDRD6/ TMEM26/ ATP1A2) was established, which was also significantly associated with positive, negative and cognitive symptoms of SCZ.</div></div><div><h3>Conclusions</h3><div>This study identified potential hub genes, pathways, and lncRNA-miRNA-mRNA regulatory networks in iPSCs that provide new insights into the molecular mechanisms of SCZ. The identified hub genes and ceRNA showed significant correlations with various clinical phenotypes of SCZ, offering potential biomarkers and therapeutic targets.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 22-29"},"PeriodicalIF":3.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on “Speaking of yourself: A meta-analysis of 80 years of research on pronoun use in schizophrenia”","authors":"","doi":"10.1016/j.schres.2025.04.014","DOIUrl":"10.1016/j.schres.2025.04.014","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 20-21"},"PeriodicalIF":3.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune psychosis: Psychopathological patterns and outcome after immunotherapy","authors":"Jesus Ramirez-Bermudez ,&nbsp;Mariana Espinola-Nadurille ,&nbsp;Miguel Restrepo-Martinez ,&nbsp;Victoria Martínez-Ángeles ,&nbsp;Francisco Martínez-Carrillo ,&nbsp;Lissy Cascante ,&nbsp;Paloma Valdeiglesias ,&nbsp;Monserrat Mondragón ,&nbsp;Jazmín Armenta ,&nbsp;Josué García Almánzar ,&nbsp;Verónica Rivas-Alonso ,&nbsp;José Flores-Rivera ,&nbsp;Oscar Arias-Carrión ,&nbsp;Tomas A. Pollak","doi":"10.1016/j.schres.2025.04.024","DOIUrl":"10.1016/j.schres.2025.04.024","url":null,"abstract":"<div><h3>Background</h3><div>The diagnostic criteria for “autoimmune psychosis” have been proposed to identify patients presenting with psychotic symptoms of autoimmune origin. Here, we aim to characterize the psychopathological features and outcomes of patients diagnosed with autoimmune psychosis.</div></div><div><h3>Methods</h3><div>We describe a cohort study conducted at the National Institute of Neurology and Neurosurgery of Mexico, including patients with psychotic symptoms exhibiting features of possible autoimmune psychosis: a) catatonia, b) dyskinesia, c) seizures, d) signs of neuroleptic malignant syndrome or clinical worsening after use of antipsychotics, or e) severe cognitive impairment.</div></div><div><h3>Results</h3><div>Of 195 psychotic patients under assessment, 164 patients were diagnosed as having psychosis of autoimmune origin and received immunotherapy. Hallucinations were present in 83 %, delusions in 77 %, and disorganized speech in 64 % of the cases. Severe cognitive dysfunction was present in 75 % while 64 % were diagnosed with catatonia. Seizures were the most common neurological feature (63 %), followed by movement disorders and autonomic abnormalities. Most patients (71%) were diagnosed as having definite anti- NMDAR encephalitis. A significant proportion of the cases (39 %) had been previously misdiagnosed as having a primary psychiatric disorder. After immunotherapy, most patients with anti-NMDA receptor encephalitis, or with a negative determination of NMDA receptor antibodies, experienced cognitive and functional improvement, and a significant reduction in psychotic symptoms.</div></div><div><h3>Conclusions</h3><div>Our study supports previous observations about the value of the autoimmune psychosis construct, the pleomorphic psychopathological patterns of autoimmune encephalitis, and the significant improvement of psychopathology after immunotherapy</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 10-19"},"PeriodicalIF":3.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High rates of suicidality and parasuicidal behavior in individuals at clinical high-risk for psychosis: Implications for suicide risk assessment and suicide prevention","authors":"Tara Trujillo ,&nbsp;Heline Mirzakhanian ,&nbsp;Jean Addington ,&nbsp;Carrie E. Bearden ,&nbsp;Tyrone D. Cannon ,&nbsp;Barbara A. Cornblatt ,&nbsp;Matcheri Keshavan ,&nbsp;Daniel H. Mathalon ,&nbsp;Diana O. Perkins ,&nbsp;William Stone ,&nbsp;Elaine F. Walker ,&nbsp;Scott W. Woods ,&nbsp;Kristin S. Cadenhead","doi":"10.1016/j.schres.2025.04.030","DOIUrl":"10.1016/j.schres.2025.04.030","url":null,"abstract":"<div><h3>Background</h3><div>Prior early psychosis studies have reported higher rates of suicidal ideation (SI) and parasuicidal behavior compared to healthy controls, but there is limited research examining rates and predictors of SI or protective factors in clinical high risk (CHR) youth. We investigated suicidality in CHR participants in the third sample of the North American Prodrome Longitudinal Study (NAPLS-3) and investigated associated demographic, life event, symptom, functional, treatment and outcome information.</div></div><div><h3>Methods</h3><div>The sample included 710 CHR (mean age 18.2, 45.8 % female) and 96 healthy control (HC) participants (mean age 18.6, 50.0 % female). Past SI, plans, self-harm and attempts were assessed via the clinician-administered Structured Assessment of Violence Risk in Youth (SAVRY) scale and the Calgary Depression Scale for Schizophrenia (CDSS).</div></div><div><h3>Results</h3><div>A significantly greater proportion of CHR participants compared to HC participants endorsed a history of SI or plan (30.7 % vs 0 %), a history of self-harm with no intent (25.6 % vs 4.2 %), serious suicide attempts (12 % vs 0 %) and suicide attempts designed to end in death (1 % vs 0 %). Within the CHR group, increasing levels of suicidality were significantly associated with worse symptoms; comorbid DSM diagnoses; decreased global and premorbid functioning; and stressful life events at baseline. Although parasuicidal behavior predicted future general symptoms including dysphoria and stress intolerance, it did not predict psychotic conversion at future timepoints.</div></div><div><h3>Conclusion</h3><div>Suicidality is prominent in CHR youth and an indicator of greater acuity, highlighting the importance of suicide risk assessments and suicide prevention interventions specifically targeted to CHR youth.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"281 ","pages":"Pages 1-9"},"PeriodicalIF":3.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}