Schizophrenia Research最新文献

{"title":"The MATRICS Consensus Cognitive Battery (MCCB) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): Convergent validity","authors":"Faith Dickerson , Andrea Origoni , Emily Katsafanas , Kelly Rowe , Sabahat Khan , Allana Therese Calahatian , Fahad Mukhtar , Robert Yolken","doi":"10.1016/j.schres.2025.09.015","DOIUrl":"10.1016/j.schres.2025.09.015","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 183-184"},"PeriodicalIF":3.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The burden of early onset psychosis: Diagnostic complexity, high comorbidity, and poor functioning in patients and their relatives","authors":"Josephine Mollon ,&nbsp;Nuria Lanzagorta ,&nbsp;Samuel R Mathias ,&nbsp;Amanda Rodrigue ,&nbsp;Emma E.M. Knowles ,&nbsp;Emma Deaso ,&nbsp;Laura Cadavid ,&nbsp;Jimena Unzueta Saavedra ,&nbsp;Catherine Brownstein ,&nbsp;Eugene D'Angelo ,&nbsp;Joseph Gonzalez-Heydrich ,&nbsp;Patricia Zavaleta Ramírez ,&nbsp;Emmanuel Sarmiento ,&nbsp;Carlos Bustamante ,&nbsp;Christopher A. Walsh ,&nbsp;Laura Almasy ,&nbsp;Humberto Nicolini ,&nbsp;David C. Glahn","doi":"10.1016/j.schres.2025.09.022","DOIUrl":"10.1016/j.schres.2025.09.022","url":null,"abstract":"<div><h3>Background</h3><div>The Early Psychosis Investigation Centers in Mexico (EPIMex) and Boston (EPICenter) recruit children and adolescents with early onset psychosis (EOP), their relatives, and controls to elucidate risk factors for EOP.</div></div><div><h3>Methods</h3><div>In Mexico, data were available for 860 EOP probands, 493 relatives, and 865 controls, and in Boston, for 120 EOP probands, 182 relatives, and 60 controls. Psychiatric diagnoses were ascertained using the Structured Clinical Interview for the DSM-V (SCID-5). General cognitive ability was calculated using 7 cognitive tests. Functioning and symptoms were ascertained with the Children's Global Assessment Scale or Global Assessment of Functioning scale, and the Brief Psychiatric Rating Scale, respectively. EOP probands, relatives with and without diagnoses, and controls with nonpsychotic diagnoses were compared to controls without diagnoses.</div></div><div><h3>Results</h3><div>In Mexico, over 86 % of EOP probands had at least one psychiatric comorbidity, and 73 % of relatives had a psychiatric diagnosis, with 52 % having multiple diagnoses. In Boston, 77 % of EOP probands had at least one psychiatric comorbidity, and 80 % of relatives had a psychiatric diagnosis, with 42 % having multiple diagnoses. In Mexico, EOP probands, and relatives showed small cognitive deficits (effect size (ES) = 0.22–0.29, <em>p</em> &lt; .05). In Boston, all groups showed large cognitive deficits (ES = 0.82–1.28, <em>p</em> = .001). Across both sites, all diagnostic groups (EOP probands, relatives and controls with diagnoses) showed poor functioning (ES = 0.87–1.92, <em>p</em> &lt; .001), and severe symptoms (ES = 0.52–1.71, <em>p</em> &lt; .02), and only 17 % of EOP probands showed “good” functioning (GAF/CGAS&gt;70).</div></div><div><h3>Conclusions</h3><div>Early onset psychosis (EOP) is associated with high comorbidity, and poor functioning in patients, and their relatives.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 165-174"},"PeriodicalIF":3.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age- and sex-dependent effects of stressors on activity of the nucleus reuniens of the thalamus","authors":"Daniela L. Uliana ,&nbsp;Anthony A. Grace","doi":"10.1016/j.schres.2025.09.018","DOIUrl":"10.1016/j.schres.2025.09.018","url":null,"abstract":"<div><h3>Background</h3><div>Stress is a significant socio-environmental risk factor for schizophrenia, with its impact varying with age and sex. Male rats are more vulnerable to the long-term effecct of stress during early adolescence, whereas females are more affected during late adolescence, with both demonstrating a stress-induced hyperdopaminergic state and ventral hippocampal hyperexcitability. The nucleus reuniens of the thalamus (RE) plays a crucial role in modulating hippocampal-prefrontal connectivity and dopamine activity. This study investigated the effect of stress during neurodevelopment on RE activity in both sexes.</div></div><div><h3>Study design</h3><div>Sprague-Dawley rats were subjected to a 10-day footshock and restraint stress protocol during early adolescence (Post-natal day [PD] 31–40) or late adolescence (PD41–50) periods. Electrophysiological RE recordings were conducted 1–2 and 5–6 weeks post-stress.</div></div><div><h3>Study results</h3><div>Early adolescence stress did not affect the number of spontaneously active RE neurons in males and females after 1–2 or 5–6 weeks, but it increased the proportion of RE neurons firing in bursts in females. Late adolescence stress increased the number of spontaneously active RE neurons in females at both 1–2 and 5–6 weeks. Females had fewer active RE neurons than males starting earlier in adulthood but not at a younger age (PD47–54). This shows an age-dependent effect on female RE activity.</div></div><div><h3>Conclusion</h3><div>Stress had sex-specific effects on RE neuron activity of females, with late adolescence stress increasing the number of spontaneous RE neurons, while early adolescence stress influenced burst firing. Therefore, stress-induced changes in RE activity during adolescence may contribute to females' vulnerability to neuropathology.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 155-164"},"PeriodicalIF":3.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning health systems in early interventions for psychosis: Establishing consumer voices in clinical high-risk for psychosis care","authors":"Emily E. Carol ,&nbsp;Joey Rodriguez ,&nbsp;P. Esra Guvenek-Cokol ,&nbsp;Hyun Jung Kim ,&nbsp;Zachary B. Millman ,&nbsp;Tamara Welikson ,&nbsp;Dost Öngür","doi":"10.1016/j.schres.2025.09.017","DOIUrl":"10.1016/j.schres.2025.09.017","url":null,"abstract":"<div><div>Learning health systems (LHS) are becoming established in First Episode Psychosis (FEP) treatment settings and have facilitated data driven improvements in FEP treatment and recovery outcomes. Early psychosis treatment has also expanded to provide targeted early intervention to youth who are at increased risk of developing psychosis spectrum illness, characterized as individuals at clinical high risk for psychosis (CHR-p). This has led to a national expansion of CHR-p programs and an increased focus on developing evidence-based treatment models for youth with CHR-p. The heterogeneity and high frequency of co-morbidities observed among youth with CHR-p remains a constant challenge for CHR-p programs to navigate and contributes to a lack of standardized understanding of the help seeking youth's individualized priorities for CHR-p treatment. While LHS in CHR-p treatment offer unique frameworks to address unanswered questions in this growing area, they are less established. The Psychosis Risk Assessment Feedback Survey was developed for CHR-p clinical use to directly assess individuals' experiences participating in CHR-p clinical assessments, receiving CHR-p diagnostic impressions, and discussing treatment recommendations. The aim of this commentary is to highlight the need for utilizing LHS to better understand youth with CHR-p and their caregivers experiences, provide a platform for them to have a voice at the earliest stages of treatment, introduce a novel survey method, and outline methods for integrating data back into clinical care to inform individualized assessment and treatment.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 149-154"},"PeriodicalIF":3.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hippocampus: At the nexus of risk and resilience for schizophrenia","authors":"Katherine S.F. Damme","doi":"10.1016/j.schres.2025.09.016","DOIUrl":"10.1016/j.schres.2025.09.016","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 141-148"},"PeriodicalIF":3.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with attempts to stop smoking in people with psychotic disorders","authors":"P. Di Prinzio ,&nbsp;T. Hall ,&nbsp;Vera A. Morgan ,&nbsp;A. Waterreus","doi":"10.1016/j.schres.2025.09.012","DOIUrl":"10.1016/j.schres.2025.09.012","url":null,"abstract":"<div><div>Smoking rates in the Australian adult general population have dropped steadily but, in people with psychotic disorders, they remain highly prevalent and unchanged. Higher levels of nicotine dependence, high rates of cannabis co-use and a greater likelihood of being around other smokers may be barriers for smokers with psychotic disorders to attempt to stop. The health and social challenges smoking contributes to this population make it critical to understand how to better address this issue.</div><div>In this study, we examined smoking behaviours in 380 people with psychotic disorders. We aimed to identify factors associated with making a past-year attempt to stop smoking.</div><div>Results showed 81.3 % of participants were lifetime smokers, of whom 59.5 % were current smokers and 21.8 % had stopped. A total of 38.1 % of current smokers reported making a past-year attempt to stop. Factors associated with significantly increased odds of a past-year attempt included not enjoying smoking, discussing smoking with a GP, a past-year hospital admission, engaging in moderate to high levels of physical activity, and stopping cannabis use. The more cigarettes smoked, the lower the odds of an attempt to stop. Past-year mental health symptoms were not associated with making a stop attempt.</div><div>Concerted efforts are needed by all health professionals to reduce the high rates of smoking in this population. Encouraging and supporting people with psychotic disorders to make lifestyle changes including engaging in physical activity, ceasing cannabis use and reducing the number of cigarettes used may result in more smokers making an attempt to stop.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 134-140"},"PeriodicalIF":3.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal analysis of absolute neutrophil count (ANC) variability and neutropenia incidence in African American schizophrenia patients by ACKR1 genotype","authors":"Sonja Xie ,&nbsp;Matthew Glassman ,&nbsp;Gopal Vyas ,&nbsp;Evaristus Nwulia ,&nbsp;Deanna L. Kelly","doi":"10.1016/j.schres.2025.09.011","DOIUrl":"10.1016/j.schres.2025.09.011","url":null,"abstract":"<div><h3>Background</h3><div>About 30–50 % of schizophrenia patients are unresponsive to treatment. Clozapine is the only FDA-approved antipsychotic for treatment-resistant schizophrenia (TRS) but is disproportionally underutilized in African American populations due to concern over clozapine-induced neutropenia (absolute neutrophil count [ANC] &lt; 1500 cells/mm³). Healthy Black individuals have a lower normative ANC, associated with the “ACKR1-null” CC genotype (SNP rs2814778) and termed Benign Ethnic Neutropenia (BEN).</div></div><div><h3>Methods</h3><div>To elucidate clozapine risk in this population, we characterized the natural ANC progression in 72 African American schizophrenia patients over 7-weeks to establish a necessary baseline for comparison. Weekly blood tests and TaqMan PCR genotyping were performed. Mixed-effects models (MEM) assessed ANC variability and multinomial logistic regression analyzed neutropenia incidence. Factors included ACKR1 genotype, age, sex, and study site. Medication effects (lithium, antidepressants, anticholinergics, anticonvulsants) on ANC were assessed using generalized estimating equations (GEE).</div></div><div><h3>Results</h3><div>51/72 participants (70.83 %) were ACKR1-<em>null</em>, exhibiting significantly lower ANC (2800.80 ± 1425.87) compared to the CT/TT group (4958.72 ± 1900.30) (<em>p</em> = 3.99 × 10⁻¹⁵). Neutropenia was more prevalent in the ACKR1-<em>null</em> group (31.4 % [16/51]) compared to the CT/TT group (0 % [0/21]) (<em>p</em> = 0.004), and participants with neutropenia averaged 2.1 ± 1.6 episodes over the 7-week period. Lithium was significantly correlated with higher ANC (<em>p</em> &lt; 0.001). Antidepressant effects varied by genotype, increasing ANC in C-type (<em>p</em> = 0.007) and decreasing ANC in T-type (p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Findings suggest that nearly one-third of healthy African Americans experience neutropenia without clozapine-use. Baseline ANC resembles levels seen during clozapine, reinforcing its safety for broader utilization.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 124-131"},"PeriodicalIF":3.5,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking psychosis: Time to retire “organic”, “idiopathic” and “secondary”?","authors":"Matcheri S. Keshavan ,&nbsp;Megan Good","doi":"10.1016/j.schres.2025.09.009","DOIUrl":"10.1016/j.schres.2025.09.009","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 132-133"},"PeriodicalIF":3.5,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does adjunctive electro-convulsive therapy improve the speed of treatment response in schizophrenia? A systematic review and week-by-week meta-analyses of controlled clinical trials","authors":"Makarand Pantoji,&nbsp;Srinivas Balachander,&nbsp;Palash Prajapati,&nbsp;Shyam Sundar Arumugham,&nbsp;Ganesan Venkatasubramanian,&nbsp;Jagadisha Thirthalli","doi":"10.1016/j.schres.2025.08.018","DOIUrl":"10.1016/j.schres.2025.08.018","url":null,"abstract":"<div><h3>Background</h3><div>Electroconvulsive therapy (ECT) is sometimes recommended in patients with schizophrenia to hasten clinical response. However, there is limited research comparing the speed of response between ECT in combination with antipsychotic medication versus antipsychotics alone. We conducted a systematic review and meta-analyses of week-by-week clinical response to examine whether ECT augmentation leads to faster improvement in psychotic symptoms in patients with schizophrenia.</div></div><div><h3>Methods</h3><div>We searched PubMed/Medline and Cochrane Library for controlled trials which compared the combination of ECT and antipsychotic drugs (ECT + AP) with antipsychotic drugs alone (AP) in patients with schizophrenia. We performed a pairwise random-effects meta-analysis for each time point. Hedge's g was used as the effect size estimate. A multivariate mixed-effects meta-analysis was performed to test whether the response speed was different between the groups.</div></div><div><h3>Results</h3><div>Of a total of 4899 search results, 12 studies were included. In five of them, the authors reported that the ECT + AP group responded faster. Pairwise meta-analysis for each week showed that ECT + AP group was significantly superior to the AP group at week 1 [g = 0.897 (95 % CI 0.236–1.557)], week 2 [g = 0.986 (95 % CI 0.273–1.700)], and week 4 [g = 1.587 (95 % CI 0.180–2.995)], but not after that. The multivariate mixed-effects meta-analysis also showed a significant Group*Week interaction [B = 0.17(95 % CI 0.10–0.24), <em>p</em> &lt; 0.001].</div></div><div><h3>Conclusions</h3><div>ECT augmentation in schizophrenia, given its potential for faster response, may have some advantage in acutely ill patients, particularly those requiring hospitalization and needing rapid symptom resolution.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 114-123"},"PeriodicalIF":3.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sleep disturbances and gray matter volume in individuals at clinical high-risk for psychosis and healthy controls: A longitudinal MRI study (NAPLS-3)","authors":"Babet N. Wezenberg ,&nbsp;Merel Koster ,&nbsp;Guido van Wingen ,&nbsp;Lieuwe de Haan ,&nbsp;Marieke van der Pluijm","doi":"10.1016/j.schres.2025.09.010","DOIUrl":"10.1016/j.schres.2025.09.010","url":null,"abstract":"<div><h3>Objective</h3><div>Sleep disturbances and brain alterations are common in psychotic disorders and individuals at clinical high risk for psychosis (CHR-P). It remains unclear whether gray matter volume changes are inherent to psychosis or partly driven by sleep disturbances. This study investigated whether sleep disturbances contribute to progressive structural brain changes.</div></div><div><h3>Methods</h3><div>Data were obtained from the North American Prodrome Longitudinal Study (NAPLS-3), including 507 CHR-P individuals (mean age 19; 56.0 % male) and 81 healthy controls (HC) (mean age 19; 49.4 % male), assessed with the Pittsburgh Sleep Quality Index (PSQI) and 3 T structural MRI at baseline and prospectively for 8 months. Cross-sectional associations between sleep and gray matter volume were assessed with whole-brain voxel-based morphometry analysis. Longitudinal associations between persistent sleep disturbances and thalamus, hippocampus, and cerebellum volume were examined using linear mixed models.</div></div><div><h3>Results</h3><div>Sleep disturbances were highly prevalent in CHR-P (mean PSQI = 7.45) and more common than in HC (<em>p</em> &lt; .001). No significant cross-sectional or longitudinal associations were observed between sleep disturbances and gray matter volume in CHR-P nor HC. Exploratory analyses showed that higher PSQI scores were associated with increased odds of conversion to psychosis (OR = 1.059, <em>p</em> = .040).</div></div><div><h3>Conclusions</h3><div>Our findings indicate no association between sleep disturbances and gray matter volume in CHR-P individuals or HC. This negative result suggests that sleep problems, though prevalent and predictive of psychosis risk, likely act through mechanisms other than structural brain changes, underscoring their value as accessible targets for early intervention.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"285 ","pages":"Pages 105-113"},"PeriodicalIF":3.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}