Schizophrenia Research最新文献

{"title":"Prevalence and associations of fatigue in psychosis: A systematic review and meta-analysis","authors":"Kim Poole-Wright ,&nbsp;Aakash Patel ,&nbsp;Fiona Gaughran ,&nbsp;Robin Murray ,&nbsp;Trudie Chalder","doi":"10.1016/j.schres.2025.03.027","DOIUrl":"10.1016/j.schres.2025.03.027","url":null,"abstract":"<div><h3>Background</h3><div>There is increasing interest in fatigue in people with psychotic illnesses. This systematic review and meta-analysis reviewed the evidence concerning the prevalence of fatigue and associated factors in adults with psychotic illnesses.</div></div><div><h3>Methods</h3><div>Embase, PsycINFO, Medline and CINAHL were systematically searched for articles in English published between January 1946 to 9 October 2023. Inclusion criteria was ‘fatigue’ in adults (≥18 years old) with a confirmed ICD11 or DSM5 diagnosis of a psychotic disorder. Risk of bias was assessed with the JBI and the Newcastle-Ottawa Scale. Pooled proportions for fatigue with 95 % CI were calculated using random effects models. Heterogeneity was assessed using Cochran's Q and I² statistic and Egger's tests were conducted for publication bias.</div></div><div><h3>Results</h3><div>A total of 57 articles met the inclusion criteria and 7 articles (<em>n</em> = 1161 participants) were included for the meta-analysis of fatigue. Fatigue prevalence was 55 % (95 % CI: 37–71 %, I² = 94 %). A sensitivity analysis of the 6 studies using a valid scale (<em>n</em> = 711 participants) found a fatigue proportion of 59 % (95 % CI: 41–76, I² = 93 %). Eighteen studies (<em>n</em> = 4569 participants) were included for an analysis exploring the prevalence of antipsychotic-related fatigue, which was 20.5 % (95 % CI: 11–34 %). We found no significant difference in antipsychotic-related fatigue between studies using a valid scale (27 %, 95 % CI: 14–46, k = 7) and studies using a clinical interview (17 %, 95 % CI: 7–35 %, k = 11) <em>p</em> = 0.302. An Egger's test indicated no publication bias. Quality assessments for included studies revealed that 16 % were at low risk of bias, 9 % at high risk and 75 % at moderate risk. Reported associations with fatigue included sex, age, antipsychotics, distress and depression, sleep, and some negative symptoms.</div></div><div><h3>Conclusions</h3><div>Our study revealed that a majority of people with psychosis experience fatigue. Antipsychotics, sex, and functioning may contribute to tiredness symptoms, but further research is needed.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"279 ","pages":"Pages 59-70"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OnTrackNY: A public sector learning healthcare system for youth and young adults with early psychosis","authors":"Iruma Bello ,&nbsp;Ana Stefancic ,&nbsp;Ana Carolina Florence ,&nbsp;Melanie Wall ,&nbsp;Marleen Radigan ,&nbsp;Igor Malinovsky ,&nbsp;Ilana Nossel ,&nbsp;Chackupurackal Mathai ,&nbsp;Leopoldo Cabassa ,&nbsp;Kaleigh Fidaleo ,&nbsp;Adrienne Sheitman ,&nbsp;Elaina Montague ,&nbsp;William McGuire ,&nbsp;Thomas E. Smith ,&nbsp;Lisa Dixon ,&nbsp;Sapana Patel","doi":"10.1016/j.schres.2025.03.033","DOIUrl":"10.1016/j.schres.2025.03.033","url":null,"abstract":"<div><div>Coordinated Specialty Care is a treatment model for youth and young adults experiencing early psychosis. OnTrackNY, an internationally recognized public sector learning healthcare system, operates 31 coordinated specialty care teams throughout New York State with oversight from an intermediary organization, OnTrack Central. As part of the National Institute of Mental Health Early Psychosis Intervention Network initiative, OnTrackNY utilizes a stakeholder engagement unit and a data science unit to support quality improvement. This article describes how OnTrack Central uses the Institute of Medicine's Group Health Cooperative learning healthcare system framework and learning loop approach to enhance racial equity in OnTrackNY through a multi-component quality improvement project. Qualitative interviews (<em>N</em> = 70) with OnTrackNY participants, families, and providers revealed experiences with racism and shared decision making and identified stakeholder-driven modifications to OnTrack Central's training and implementation approach. Modifications included stakeholder co-created shared decision making training modules for providers and ethnoracially minoritized participants, and a provider learning collaborative to promote shared decision making with ethnoracially diverse participants and families. Evaluation of the modules and collaborative identified barriers including limited time for providers to engage with training and a lack of confidence among trainers in delivering racial equity trainings. Results highlighted the need to adjust content and develop two workforce training programs focused on enhancing shared decision making along the continuum of OnTrackNY care. This article demonstrates how a public sector learning healthcare system can use a stakeholder-partnered approach to enhance the competency of coordinated specialty care workforce and promote equitable and data-driven care.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"279 ","pages":"Pages 50-58"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of childhood social fragmentation and perceived discrimination on maladaptive core schemas later in life among young adults at clinical high risk for psychosis and healthy comparisons","authors":"Anthony Diomino ,&nbsp;Qingyue Yuan ,&nbsp;Kristin S. Cadenhead ,&nbsp;Jean Addington ,&nbsp;Carrie E. Bearden ,&nbsp;Tyrone D. Cannon ,&nbsp;Matcheri Keshavan ,&nbsp;Daniel H. Mathalon ,&nbsp;Diana O. Perkins ,&nbsp;William S. Stone ,&nbsp;Elaine F. Walker ,&nbsp;Scott W. Woods ,&nbsp;Benson S. Ku","doi":"10.1016/j.schres.2025.03.023","DOIUrl":"10.1016/j.schres.2025.03.023","url":null,"abstract":"<div><h3>Objective</h3><div>Neighborhood social fragmentation during childhood has been linked to the future onset of psychosis and poorer social functioning. Maladaptive core schemas may partly explain this relationship. This study examines whether childhood exposure to area-level social fragmentation is associated with maladaptive core schemas in adulthood and whether perceived discrimination mediates this relationship.</div></div><div><h3>Methods</h3><div>Baseline data were collected from the North American Prodrome Longitudinal Study 2 (2009–2013). Participants included adults at clinical high-risk for psychosis (<em>N</em> = 84) and healthy comparisons (<em>N</em> = 130). Childhood social fragmentation was derived from 1990 and 2000 U.S. Census data. Lifetime perceived discrimination and brief core schemas were assessed at baseline.</div></div><div><h3>Results</h3><div>Greater childhood social fragmentation was statistically significantly associated with greater lifetime perceived discrimination (adjusted β = 0.21, 95 % CI: 0.03 to 0.39), which was in turn associated with maladaptive positive-other (adjusted β = −0.21, 95 % CI: −0.35 to −0.07) and negative-self core schemas in adulthood (adjusted β = 0.36, 95 % CI: 0.23 to 0.49). Lifetime perceived discrimination mediated 20.66 % of the relationship between childhood social fragmentation and positive-other schemas, and 35.96 % of the relationship with negative-self schemas.</div></div><div><h3>Conclusion</h3><div>In this cross-sectional study, our findings suggest that growing up in areas with greater social fragmentation may contribute to greater lifetime perceived discrimination, which may be linked to greater maladaptive core schemas in adulthood. Further prospective research is needed to explore how social fragmentation across development may impact core schema formation, with potential implications for designing interventions to mitigate maladaptive core schemas and psychopathology.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"279 ","pages":"Pages 71-78"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue highlights","authors":"","doi":"10.1016/S0920-9964(25)00131-8","DOIUrl":"10.1016/S0920-9964(25)00131-8","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"278 ","pages":"Page A1"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative symptoms in psychosis: A scoping review of qualitative studies","authors":"John Lyne ,&nbsp;Francesco Piacenza ,&nbsp;Paul Crowley ,&nbsp;Justin Smyth ,&nbsp;Brian O'Donoghue ,&nbsp;Keith Gaynor ,&nbsp;Mary Clarke","doi":"10.1016/j.schres.2025.03.032","DOIUrl":"10.1016/j.schres.2025.03.032","url":null,"abstract":"<div><h3>Introduction</h3><div>Negative symptoms in schizophrenia, characterised by the absence or reduction of normal processes, are understudied and effective treatments remain elusive. Qualitative research can provide novel and patient-centred insights into these complex phenomena. This scoping review synthesizes findings from previously published qualitative studies aiming to explore previous results and identify gaps in the published literature.</div></div><div><h3>Methods</h3><div>A systematic search was conducted on MEDLINE, CINAHL, and PsycINFO databases between April and June 2023. Qualitative studies on negative symptoms in psychotic illnesses were eligible for inclusion. Screening and data extraction procedures were performed by two reviewers working independently. Extracted findings were summarised using narrative synthesis based on consensus meetings with the research team.</div></div><div><h3>Results</h3><div>A comprehensive search yielded 4753 articles, with six studies deemed eligible for inclusion. The included studies collectively delved into the experiences, causes, and consequences of negative symptoms. Participants reported a spectrum of negative symptom experiences influenced by social dynamics, societal stigma, and childhood trauma. There was a noticeable interaction between different symptom domains, including negative symptoms, such as motivation and sociability, being influenced by positive symptoms, such as hallucinations and delusions. Studies have also highlighted the impact of prescribed medication and substance use on negative symptoms. Areas needing further qualitative research were identified, including exploring the differentiation between primary and secondary negative symptoms, and gaining a deeper understanding of negative symptom evolution over time.</div></div><div><h3>Conclusions</h3><div>This scoping review provides valuable insights into the subjective experience of negative symptoms and the multifactorial contributory factors to negative symptoms in schizophrenia. The findings, such as the interplay between negative and positive symptoms, emphasise the importance of a holistic understanding of these complex symptoms, which can be informed by qualitative exploration. Furthermore, the qualitative perspectives can enhance future research avenues, and have potential for assisting the development of more effective approaches for treating negative symptoms.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"279 ","pages":"Pages 40-49"},"PeriodicalIF":3.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What does really matter in the premorbid background of psychosis leading to long-term disability? A 21-year follow-up cohort study of first-episode psychosis","authors":"Victor Peralta ,&nbsp;Elena García de Jalón ,&nbsp;Lucía Moreno-Izco ,&nbsp;Ana M. Sánchez-Torres ,&nbsp;Gustavo J. Gil-Berrozpe ,&nbsp;David Peralta ,&nbsp;Lucía Janda ,&nbsp;Manuel J. Cuesta ,&nbsp;SEGPEPs group","doi":"10.1016/j.schres.2025.02.009","DOIUrl":"10.1016/j.schres.2025.02.009","url":null,"abstract":"<div><h3>Background</h3><div>Clinicians are currently unable to predict which patients are at higher risk of long-term disability based on premorbid factors. We aimed to determine the extent to which premorbid factors could prospectively predict long-term disability in patients with first-episode psychosis.</div></div><div><h3>Methods</h3><div>We assessed 12 potential premorbid risk factors in 243 individuals with first-episode psychosis reassessed 21 years later for several domains of psychosocial disability. Hierarchical multivariate regression and Directed Acyclic Graphs (DAGs) were used sequentially to investigate independent and causal associations between risk factors and long-term disability.</div></div><div><h3>Results</h3><div>The familial load of schizophrenia, lower parental SES, obstetric complications, early neurodevelopmental delay, childhood adversity, and poor adolescence social networks were independent predictors of long-term disability, accounting for 40.6 % of the variability. The DAGs analysis showed that both familial risk of schizophrenia and lower SES had statistically significant direct and indirect effects on later disability. The indirect effects were mediated by the variables indexing impaired development, although childhood adversity and poor adolescence social networks also had significant direct effects on disability. Early neurodevelopmental delay was the only developmental marker present in all statistically significant indirect paths from familial background factors to long-term disability, suggesting that it is a key component of the causal chain that leads to later disability.</div></div><div><h3>Conclusions</h3><div>In individuals with psychotic disorders, familial background factors appear to trigger a complex and multidetermined cascade of risk factors across developmental stages that interact iteratively, leading to long-term disability.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"279 ","pages":"Pages 31-39"},"PeriodicalIF":3.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Speaking of yourself: A meta-analysis of 80 years of research on pronoun use in schizophrenia","authors":"Dalia Elleuch ,&nbsp;Yinhan Chen ,&nbsp;Qiang Luo ,&nbsp;Lena Palaniyappan","doi":"10.1016/j.schres.2025.03.025","DOIUrl":"10.1016/j.schres.2025.03.025","url":null,"abstract":"<div><div>People with schizophrenia experience significant language disturbances that profoundly affect their everyday social interactions. Given its relevance to the referential function of language, aberrations in pronoun use are of particular interest in the study of schizophrenia. This systematic review and meta-analysis, adhering to PRISMA guidelines, examines the frequency of pronoun use in schizophrenia. PubMed, PsycINFO, Scopus, Google Scholar, and Web of Science were searched up to May 1, 2024. All studies analyzing pronoun frequency in various spoken language contexts in schizophrenia were included. Bias was assessed using a modified Newcastle–Ottawa Scale. A Bayesian meta-analysis with model averaging estimated effect sizes and moderating factors. 13 studies with <em>n</em> = 917 unique participants and 13 case-control contrasts were included. 37.9 % of patient samples were women, with a weighted mean (SD) age of 34.45 (9.72) years. 53.85 % of the studies were in languages other than English. We report a medium-sized effect for first-person pronoun impairment in schizophrenia (model-averaged d = 0.89, 95 % CrI (0.44, 1.33)). There was significant heterogeneity moderated by age. Evidence for publication bias was weak, with a strong support for first-person pronoun impairment after accounting for bias and heterogeneity. There was a small reduction of inter-individual variability in first-person pronoun use in patients compared to healthy controls (lnCVR = −0.12, 95 % CrI [−0.35, −0.13]). While <em>all pronoun</em> use was also high in patients, this was not robust due to heterogeneity and publication bias. Individuals with schizophrenia excessively use first-person pronouns. This may be a marker of a disturbed sense of self in this illness.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"279 ","pages":"Pages 22-30"},"PeriodicalIF":3.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compulsory treatment across a 2-year follow-up within an “Early Intervention in Psychosis” program in Italy: Incidence rates and baseline predictors","authors":"Lorenzo Pelizza ,&nbsp;Emanuela Leuci ,&nbsp;Emanuela Quattrone ,&nbsp;Derna Palmisano ,&nbsp;Giuseppina Paulillo ,&nbsp;Clara Pellegrini ,&nbsp;Simona Pupo ,&nbsp;Pietro Pellegrini ,&nbsp;Marco Menchetti","doi":"10.1016/j.schres.2025.03.028","DOIUrl":"10.1016/j.schres.2025.03.028","url":null,"abstract":"<div><h3>Introduction</h3><div>Individuals with First Episode Psychosis (FEP) have a higher risk of compulsory admission, but evidence on its prognostic role on outcomes and its baseline predictors is poor. The aims of this investigation were to calculate incidence rate of compulsory admission in FEP individuals treated within an Italian “Early Intervention in Psychosis” (EIP) service across 2 years of follow-up, and to compare clinical and sociodemographic characteristics between FEP patients with and without compulsory admission during the follow-up.</div></div><div><h3>Methods</h3><div>500 FEP patients were recruited within the “Parma-Early Psychosis” program and completed a socio-demographic chart, the Positive And Negative Syndrome Scale (PANSS), and the Global Assessment of Functioning (GAF) scale. For inter-group comparisons, Mann-Whitney and Chi-square tests, Kaplan-Meier survival analysis, Cox and binary logistic regression, and mixed-design ANOVA were performed.</div></div><div><h3>Results</h3><div>30 (6 %) FEP participants were compulsory admitted. At baseline, they were likely to be males and to have a diagnosis of schizophrenia and lower GAF scores. Longitudinally, they had higher risk of service disengagement, new attempted suicide, and functioning impairment, and showed significant group effects in terms of more severe positive symptoms, negative symptoms, uncooperativeness, and GAF scores (0.023 &lt; ƞ² &lt; 0.100). At baseline, the most robust predictor for compulsory treatment was uncooperativeness (HR = 1.460), while the strongest protective factor was family history of psychosis in first-degree relatives (HR = 5.790).</div></div><div><h3>Conclusions</h3><div>A not negligible part of FEP participants were compulsory admitted across the follow-up. This was longitudinally associated with poor outcomes and worse treatment response. Implementing initiatives to improve the skills of professionals to increase treatment motivation from presentation is crucial to promote positive outcomes.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"279 ","pages":"Pages 1-12"},"PeriodicalIF":3.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cluster profiles of distressing psychotic-like experiences among children and associations with genetic risk, prenatal cannabis exposure, and social-environmental characteristics","authors":"Qingyue Yuan ,&nbsp;Yinxian Chen ,&nbsp;Ying Xu ,&nbsp;Lina V. Dimitrov ,&nbsp;Benjamin B. Risk ,&nbsp;Elaine F. Walker ,&nbsp;Anke Huels ,&nbsp;Benson S. Ku","doi":"10.1016/j.schres.2025.03.034","DOIUrl":"10.1016/j.schres.2025.03.034","url":null,"abstract":"<div><h3>Background</h3><div>Distressing psychotic-like experiences (PLEs) in children are associated with an increased risk for psychiatric disorders. Recent studies suggest that different domains of psychotic symptoms could be associated with distinct risk factors, but less is known about PLEs. This study clustered PLEs into subgroups and explored the genetic and environmental characteristics associated with these profiles.</div></div><div><h3>Methods</h3><div>Data from children (<em>N</em> = 11,854) recruited as part of the Adolescent Brain and Cognitive Development Study v5.1 assessed PLEs using 21-items from the Prodromal-Questionnaire-Brief Child Version. K-medoid clustering of PLEs was conducted among children with at least one distressing PLE item at baseline (<em>n</em> = 3155). Associations of polygenic risk scores for schizophrenia (PRS-SCZ) and social-environmental characteristics with PLE subgroups were estimated using generalized multinomial mixed models, adjusting for age, sex, race/ethnicity, parental education, income-to-needs ratio, and family history of psychosis.</div></div><div><h3>Results</h3><div>We identified three distressing PLE subgroups: hallucinatory-like (<em>n</em> = 1110), paranoid-like (<em>n</em> = 1229), and multiple PLE domains (<em>n</em> = 816). Compared to those without any distressing PLEs (<em>n</em> = 8699), those with hallucinatory-like PLE were more likely to have had prenatal cannabis exposure (Odds Ratio (OR) = 1.578, 95 % CI: 1.231–2.023); paranoid-like individuals had higher PRS-SCZ (OR = 1.080, 95 % CI: 1.001–1.166); those with multiple PLE domains participated in less physical activities (OR = 0.880, 95 % CI: 0.803–0.964). All groups were more likely to have experienced greater childhood adversity and worse school environments.</div></div><div><h3>Conclusions</h3><div>We found that those with different aspects of distressing PLEs had distinct and similar genetic and environmental characteristics. These results suggest that it may be important to consider the heterogeneity of PLE in conceptualizing the development of psychosis.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"278 ","pages":"Pages 119-127"},"PeriodicalIF":3.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-disorders in schizophrenia – and ERP study of pre-reflective and reflective self-experience","authors":"Maria Chiara Piani ,&nbsp;Martin Jandl ,&nbsp;Yosuke Morishima ,&nbsp;Julie Nordgaard ,&nbsp;Thomas Koenig","doi":"10.1016/j.schres.2025.03.026","DOIUrl":"10.1016/j.schres.2025.03.026","url":null,"abstract":"<div><h3>Background &amp; hypothesis</h3><div>Self-disorders (SDs) reflect abnormalities in the basic, or pre-reflective, self and are frequently present in schizophrenia spectrum disorders (SSDs). Despite their significance, the neural correlates of these abnormalities remain underexplored. This study investigates event-related potential (ERP) correlates of SDs using a cognitive task, hypothesizing that patients with SDs would show alterations in pre-reflective and reflective self-processing. We also hypothesized that the severity of SDs, measured by the Examination of Anomalous Self Experience (EASE), would correlate with ERP changes related to the pre-reflective self and that these alterations would involve cortical midline structures (CMS).</div></div><div><h3>Study design</h3><div>Thirty-five individuals with SSDs and sixty-two healthy controls completed a verbal trait-judgment task during EEG recording that required pre-reflective and reflective self-referencing. We compared ERP responses between groups and conditions and examined correlations between EASE scores and EEG maps. Post-hoc source localization identified brain regions corresponding to pre-reflective self-processing.</div></div><div><h3>Study results</h3><div>Results revealed significant ERP differences for the pre-reflective self at 300 ms post-stimulus, while reflective self differences occurred earlier. EASE scores correlated with EEG maps associated with pre-reflective self-processing. Source estimation indicated increased activation in the dorsomedial prefrontal cortex (dmPFC), Broca's area, sensorimotor cortex, and temporal regions in patients with SSDs during pre-reflective self-processing.</div></div><div><h3>Conclusions</h3><div>These findings provide neuroimaging evidence of alterations in both pre-reflective and reflective self-experience in individuals with SDs. The correlates of pre-reflective self-experience were linked to the severity of SDs and involved brain regions overlapping with cortical midline structures, particularly the medial prefrontal cortex (mPFC).</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"279 ","pages":"Pages 13-21"},"PeriodicalIF":3.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}