Schizophrenia Research最新文献

{"title":"Corrigendum to “prevalence and multidimensional impact of sarcopenia in schizophrenia: Associations with oxidative stress, functioning, and symptom severity” [Schizophr. Res. volume 289, March 2026, pages–61-70]","authors":"Özgü Şişman, Sinay Önen","doi":"10.1016/j.schres.2026.01.017","DOIUrl":"10.1016/j.schres.2026.01.017","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"289 ","pages":"Page 112"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Highlights","authors":"","doi":"10.1016/S0920-9964(26)00049-6","DOIUrl":"10.1016/S0920-9964(26)00049-6","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"289 ","pages":"Page A1"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146189207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized double-blind inpatient study of a gluten-free diet for negative symptoms in people with schizophrenia","authors":"Deanna L. Kelly ,&nbsp;Christopher M. Lee ,&nbsp;Gopal Vyas ,&nbsp;Robert W. Buchanan ,&nbsp;Daniel J. Roche ,&nbsp;Valerie Harrington ,&nbsp;Laura M. Rowland ,&nbsp;S. Andrea Wijtenburg ,&nbsp;Bhim M. Adhikari ,&nbsp;Korrapati V. Sathyasaikumar ,&nbsp;Peter Kochunov ,&nbsp;Monica V. Talor ,&nbsp;James Waltz ,&nbsp;Fang Liu ,&nbsp;Stephanie Hare ,&nbsp;Heather A. Adams ,&nbsp;Robert Schwarcz ,&nbsp;Deepak Salem ,&nbsp;James M. Gold ,&nbsp;Sarah M. Clark ,&nbsp;William W. Eaton","doi":"10.1016/j.schres.2026.01.006","DOIUrl":"10.1016/j.schres.2026.01.006","url":null,"abstract":"<div><h3>Background</h3><div>There are no FDA-approved treatments for negative symptoms in schizophrenia and related disorders (SRD). In an SRD subgroup with systemic and central inflammation and elevated anti-gliadin immunoglobulin G antibodies (AGA IgG+), previous findings suggested that a gluten-free diet (GFD) improved negative symptoms.</div></div><div><h3>Methods</h3><div>We conducted a five-week double-blind randomized placebo-controlled inpatient trial comparing a GFD versus a gluten-containing diet (GCD) in people with SRD and elevated AGA IgG+ (<em>N</em> = 39; <em>n</em> = 21 GFD and <em>n</em> = 18 GCD). The Clinical Assessment Interview for Negative Symptoms Motivation and Pleasure (CAINS MAP) scale measured the primary outcome of negative symptoms. Secondary outcomes evaluated other symptom domains and kynurenine pathway metabolites. Also, we explored inflammatory markers and, in <em>n</em> = 20 participants, measured cerebral blood flow (CBF) using Arterial Spin Labeling, and neurochemistry using magnetic resonance spectroscopy.</div></div><div><h3>Outcomes</h3><div>Relative to a GCD, a GFD was associated with a modest decrease in CAINS MAP scores (<em>df</em> = 31.2.1, <em>F</em> = 2.96, <em>p</em> = 0.035); decrease in kynurenic acid (KYNA; <em>df</em> = 32, <em>F</em> = 9.51, <em>p</em> = 0.0042) and kynurenine (<em>df</em> = 32, <em>F</em> = 11.45, <em>p</em> = 0.0019); and increase in CBF and total creatine in frontal brain regions. KYNA and CAINS MAP change scores were correlated (<em>r</em> = 0.350, <em>p</em> = 0.039) while cognition was not impacted.</div></div><div><h3>Discussion</h3><div>Our preliminary data suggests that a GFD may be associated with modest improvements on experiential negative symptoms within an SRD subgroup. A GFD may be associated with reductions in kynurenine pathway metabolites and increased CBF. Larger and longer studies are needed to confirm negative symptom efficacy in this AGA IgG+ SRD subgroup.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"289 ","pages":"Pages 33-45"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptual organization and its visual subcomponents in schizophrenia and schizotypy: A systematic review","authors":"Roberta Cessa ,&nbsp;Andrea Ghiani ,&nbsp;Ezgi Cenk ,&nbsp;Marco Bertamini","doi":"10.1016/j.schres.2026.01.004","DOIUrl":"10.1016/j.schres.2026.01.004","url":null,"abstract":"<div><div>Perceptual organization (PO) deficits have long been considered a hallmark of schizophrenia (SZ), reflecting disruptions in the integration of visual information. This systematic review critically evaluates the behavioral evidence for PO impairments in SZ and individuals with high schizotypal traits, focusing on three key mid-level processes: contour integration, perceptual grouping, and figure-ground segmentation. Forty-four studies were included, identified through a systematic search and evaluated for bias using the QUADAS-2 tool.</div><div>Findings reveal robust and replicable deficits in contour integration among individuals with SZ, especially in those with disorganization symptoms, suggesting impaired lateral interactions in early visual areas. Perceptual grouping deficits were also prominent but appeared more sensitive to cognitive load and stimulus complexity, consistent with top-down integration failures. Figure-ground segmentation impairments were less consistently reported and often dependent on task demands, emerging more clearly under challenging conditions.</div><div>In schizotypy, evidence of PO deficits was more variable. Some studies identified subtle impairments in contour integration and grouping, particularly under high attentional load or in individuals with disorganized traits, while others reported intact performance. The heterogeneity of methods across studies, particularly differences in stimulus type, complexity, and grouping cues, was a major limiting factor for cross-study comparisons.</div><div>Findings from this review support a dimensional view of PO deficits, where specific symptom clusters, rather than diagnosis alone, predict perceptual dysfunction. PO impairments, particularly in contour integration, may serve as sensitive cognitive markers for early detection and targeted intervention in SZ-spectrum disorders.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"289 ","pages":"Pages 46-60"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Enhancing cognitive control in schizophrenia with transcranial direct current stimulation and targeted cognitive training","authors":"Mohammed A. Mashal ,&nbsp;Cathy S. Chen ,&nbsp;Ian S. Ramsay ,&nbsp;Sophia Vinogradov ,&nbsp;Caroline Demro","doi":"10.1016/j.schres.2026.01.013","DOIUrl":"10.1016/j.schres.2026.01.013","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"289 ","pages":"Pages 89-93"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychopathology distinguishing secondary (“organic”) psychoses: A systematic review and meta-analysis","authors":"Graham Blackman ,&nbsp;Hamilton Morrin ,&nbsp;Claire Carstairs ,&nbsp;Jack B. Fanshawe ,&nbsp;Cameron Watson ,&nbsp;Mao Fong Lim ,&nbsp;Jonathan Phillips ,&nbsp;Adam E. Handel ,&nbsp;Robert A. McCutcheon ,&nbsp;John Headley Ward ,&nbsp;Elisavet Pappa ,&nbsp;Emily M.L. Bowman ,&nbsp;Rachel T.S. Chow ,&nbsp;Thomas A. Pollak ,&nbsp;Philip McGuire ,&nbsp;Vaughan Bell","doi":"10.1016/j.schres.2026.01.007","DOIUrl":"10.1016/j.schres.2026.01.007","url":null,"abstract":"<div><div>A significant minority of patients who present with psychosis have an underlying medical (“organic”) cause. Some of these secondary causes are reversible; therefore, early detection is critical. Psychopathology may be informative during initial assessment to determine which patients are at an increased risk of having an underlying medical cause and should be prioritised for enhanced investigation.</div><div>Through a pre-registered (CRD42024511546) systematic review and meta-analysis, we compared the psychopathology of patients with psychosis secondary to a medical cause compared to patients with primary psychosis as reported in case-control studies using PubMed from inception to September 2025. We identified 13 studies and a pooled sample size of 1564 individuals (primary psychosis = 781, secondary psychosis = 783). Poverty of speech (RR = 18.18, 95% CI = 1.43–231.5) and visual hallucinations (RR = 1.35, 95% CI 1.02–1.80) were more likely to be features of psychosis that was secondary to an underlying medical cause compared to a primary psychotic disorder. Conversely, auditory hallucinations (RR = 0.55, 95% CI = 0.50–0.61), thought insertion (RR = 0.24, 95% CI = 0.12–0.48), thought broadcast (RR = 0.30, 95% CI = 0.09–0.98), unspecified delusions (RR = 0.44, 95% CI = 0.30–0.66), delusions of persecution (RR = 0.72, 95% CI = 0.62–0.84), olfactory hallucinations (RR = 0.34, 95% CI = 0.18–0.63), and tactile hallucinations (RR = 0.26, 95% CI = 0.19–0.35) were more likely to be features of a primary psychosis. Findings underscore the clinical value of a comprehensive psychiatric assessment in patients with undifferentiated psychosis. Secondary psychoses show psychopathological differences, with certain symptoms potentially serving as ‘red flags’ for secondary causes. These indicators may assist clinicians in prioritising patients for further investigation.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"289 ","pages":"Pages 106-111"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and fall risk in schizophrenia: Which components drive the risk of falls?","authors":"Tomomi Sugisaki ,&nbsp;Norio Sugawara ,&nbsp;Masataka Shinozaki ,&nbsp;Narifumi Yokoyama ,&nbsp;Ryota Yoshida ,&nbsp;Yasushi Kawamata ,&nbsp;Norio Yasui-Furukori","doi":"10.1016/j.schres.2026.01.005","DOIUrl":"10.1016/j.schres.2026.01.005","url":null,"abstract":"<div><h3>Objectives</h3><div>Frailty is increasingly recognized in schizophrenia and is linked to adverse outcomes such as fall. However, mechanisms connecting body composition to frailty and fall risk in psychiatric inpatients remain insufficiently understood. This study aimed to examine (1) the association between fat-free mass and frailty; (2) the relationship between frailty and fall in the past 12 months; and (3) which frailty components most strongly relate to fall among inpatients with schizophrenia.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, 195 hospitalized adults (≥40 years; mean age 65.9 years) with schizophrenia or schizoaffective disorder were assessed. Frailty was defined using the Japanese version of the Cardiovascular Health Study (J-CHS) criteria. Body composition was measured by bioelectrical impedance analysis to compute fat-free mass index (FFMI) and fat mass index (FMI).</div></div><div><h3>Results</h3><div>Frailty prevalence was 32.8% (prefrail 54.9%; robust 12.3%). Higher FFMI was independently associated with lower odds of being frail. Frailty was strongly associated with fall history (OR = 9.85 vs. prefrail/robust). Across individual frailty components, slowness (reduced gait speed) showed the strongest relationship with fall.</div></div><div><h3>Conclusions</h3><div>Frailty is highly prevalent among inpatients with schizophrenia and strongly predicts fall risk. Among the individual frailty components, slowness was the key driver of fall, pointing to gait impairment as a critical focus for intervention. Routine gait assessment, combined with physiotherapy, nutritional support, and careful medication review, may help reduce frailty and prevent fall in this population. Prospective studies are needed to confirm these associations and to establish effective strategies for fall prevention in schizophrenia.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"289 ","pages":"Pages 18-24"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic seizure therapy preserves delayed memory and 40-Hz auditory steady-state responses compared with electroconvulsive therapy in schizophrenia","authors":"Yawen Hong ,&nbsp;Jiangling Jiang ,&nbsp;Jin Li ,&nbsp;Xiaochen Tang ,&nbsp;Xiong Jiao ,&nbsp;Zhenying Qian ,&nbsp;Yingying Tang ,&nbsp;Tianhong Zhang ,&nbsp;Chunbo Li ,&nbsp;Jijun Wang","doi":"10.1016/j.schres.2026.01.001","DOIUrl":"10.1016/j.schres.2026.01.001","url":null,"abstract":"<div><h3>Background</h3><div>Electroconvulsive therapy (ECT) is effective for schizophrenia but often impairs delayed memory, whereas magnetic seizure therapy (MST) typically spares cognition. We investigated whether these modalities differentially affect 40-Hz auditory steady-state responses (ASSR)—a marker of gamma synchrony critical for memory—and if these changes predict cognitive outcomes.</div></div><div><h3>Methods</h3><div>This study is a secondary analysis of a randomized clinical trial for schizophrenia comparing ECT (<em>n</em> = 16) and MST (<em>n</em> = 17). Clinical symptoms and cognition were assessed using Positive and Negative Syndrome Scale (PANSS) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) at baseline and after 10 treatment sessions. 40-Hz ASSR were recorded via EEG at baseline and after the first treatment session.</div></div><div><h3>Results</h3><div>Both treatments improved psychotic symptoms. However, ECT induced cognitive deficits (particularly delayed memory) and significant reductions in acute ASSR power and phase-locking. In contrast, MST preserved both cognitive function and ASSR integrity. Notably, within the ECT group, greater acute suppression of ASSR power predicted better preservation of delayed memory.</div></div><div><h3>Conclusion</h3><div>MST demonstrates a superior safety profile compared to ECT, preserving both gamma synchrony and memory. The association between acute gamma suppression and better memory retention in ECT suggests this reduction may be an adaptive physiological response. Thus, early ASSR changes may serve as a predictive biomarker for cognitive tolerability.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"289 ","pages":"Pages 10-17"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative symptoms across developmental stages in psychosis spectrum","authors":"Vijay A. Mittal ,&nbsp;Wing-Chung Chang ,&nbsp;Elaine F. Walker","doi":"10.1016/j.schres.2026.01.018","DOIUrl":"10.1016/j.schres.2026.01.018","url":null,"abstract":"<div><div>Negative symptoms are a core feature of schizophrenia and other psychoses that contribute substantially to functional disability but benefit little from standard treatment, thus representing an unmet therapeutic need. In fact, mechanisms underlying negative symptoms emerge in the early years of development and progress across various developmental stages of psychosis course. In premorbid period, subtle social withdrawal as well as deficits in emotion expression and social communication may represent early signals indicating vulnerability for a variety of disorders including schizophrenia. Attenuated negative symptoms, which manifest in the 5 consensus domains of anhedonia, avolition, asociality, alogia and blunted affect, are prevalent in prodromal period, predictive of conversion to full-blown psychosis, and associated with role and social dysfunction. Negative symptoms in both early psychosis and chronic schizophrenia are best conceptualized by the 5 consensus symptom domains. Greater severity of negative symptoms in first-episode psychosis is associated with more functional impairment, poorer premorbid adjustment and longer duration of untreated psychosis. There is progressive accrual of negative symptoms along the course of illness, in particular primary persistent negative symptoms which are more prevalent in the chronic illness stage, contributing to pronounced functional impairment and worse prognosis. In this article, we review the manifestations of negative symptoms in the context of developmental framework, highlighting the trajectory of negative symptoms across and the unique relevance for different stages of psychotic illness, as well as its relationships with functional disability, other illness-related factors, and treatment implications.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"289 ","pages":"Pages 100-105"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146053788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antipsychotic-disease duration interaction on glymphatic function in first-episode schizophrenia: Evidence from DTI-ALPS","authors":"Haitao Chen ,&nbsp;Hong Xiang ,&nbsp;Meng Zhang ,&nbsp;Yun Wen ,&nbsp;Shiyou Tang ,&nbsp;Shuping Tan ,&nbsp;Jiahua Xu","doi":"10.1016/j.schres.2026.01.010","DOIUrl":"10.1016/j.schres.2026.01.010","url":null,"abstract":"<div><h3>Background</h3><div>The glymphatic system's role in early schizophrenia remains unclear. This study investigated glymphatic function using the DTI-ALPS index in first-episode schizophrenia (FES), exploring its relationships with clinical features, antipsychotic treatment, and cognitive function.</div></div><div><h3>Methods</h3><div>The study included 37 first-episode drug-naïve (FESDN) patients, 22 first-episode treated (FEST) patients, and 42 demographically matched healthy controls (HCs). ALPS indices were calculated, and clinical assessments included cognitive function (RBANS), psychiatric symptoms (PANSS), and peripheral biomarkers.</div></div><div><h3>Results</h3><div>FES patients exhibited left-hemisphere predominant reductions in ALPS indices (<em>p</em> &lt; 0.01). An interaction was observed between disease duration and treatment: the FEST group had lower DTI-ALPS than the FESDN group in patients with shorter illness durations, but this group difference diminished with longer disease duration (βinter = −0.8 × 10^–2, <em>p</em> &lt; 0.05). The ALPS-cognition association pattern differed between patients and HCs: left ALPS was positively correlated with RBANS in HCs (βHC &gt; 0, <em>p</em> &lt; 0.01) but negatively correlated in FES patients (βFESDN = −16.6, βFEST = −21.6, <em>p</em> &lt; 0.1). Peripheral white blood cell count and total bilirubin were negatively associated with left ALPS in the FEST group (WBC: β = −0.63 × 10^–2, <em>p</em> = 0.025; TBIL: β = −0.80 × 10^–2, <em>p</em> = 0.039), with significant group interaction effects (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>FES patients demonstrate left-lateralized glymphatic dysfunction, the severity of which is dynamically modulated by treatment and disease duration. The observed negative ALPS‑cognition correlation raises the possibility of a compensatory mechanism in early schizophrenia. Associations noted between peripheral inflammatory/metabolic markers and ALPS offer tentative support for an interactive “periphery–brain” clearance system. DTI-ALPS may serve as a dynamic biomarker reflecting neuropathological mechanisms in early schizophrenia.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"289 ","pages":"Pages 79-88"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}