Schizophrenia Research最新文献

{"title":"16p11.2 duplication syndrome-associated psychosis: An illustrative case and review of the literature","authors":"Mark Ainsley Colijn","doi":"10.1016/j.schres.2024.12.006","DOIUrl":"10.1016/j.schres.2024.12.006","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"275 ","pages":"Pages 76-78"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autism-spectrum quotient mediates the relationship between clinical symptoms and quality of life in schizophrenia","authors":"Miki Ishizuka ,&nbsp;Sadao Otsuka ,&nbsp;Jun Miyata ,&nbsp;Yujiro Yoshihara ,&nbsp;Manabu Kubota ,&nbsp;Toshiya Murai","doi":"10.1016/j.schres.2024.12.007","DOIUrl":"10.1016/j.schres.2024.12.007","url":null,"abstract":"<div><h3>Background</h3><div>Social dysfunctions can affect the quality of life (QOL) of patients with schizophrenia. The autism-spectrum quotient (AQ) is a widely used measure of innate autistic traits. However, in patients with schizophrenia, the score may represent the severity of autism-like social dysfunctions as a consequence of symptoms. We tested the hypothesis that AQ would mediate the relationship between clinical symptoms and QOL in patients with schizophrenia, based on the assumption that the AQ measures autism-like social dysfunctions rather than autistic traits in this population.</div></div><div><h3>Methods</h3><div>We analyzed data from 108 outpatients with schizophrenia. The relationships among the scores on the Positive and Negative Syndrome Scale (PANSS), the Schizophrenia Quality of Life Scale (SQLS), and the AQ were examined using structural equation modeling (SEM).</div></div><div><h3>Results</h3><div>Path analyses of the total scale scores revealed partial mediation, but not full mediation or independent effects. However, both the AQ and PANSS scores could be mediators. SEM including the three domain scores of PANSS, the two factors of the AQ, and the three subscale scores of the SQLS showed a good fit of the AQ mediation model, but not the symptom mediation model, supporting our hypothesis. In this final model, the relationship between negative symptoms and QOL was mediated by autism-like social dysfunctions, whereas positive symptoms directly affected QOL.</div></div><div><h3>Conclusions</h3><div>Our findings advance our understanding of what the AQ measures when applied to patients with schizophrenia and suggest that autism-like social dysfunctions are important treatment targets for improving QOL in this population.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"275 ","pages":"Pages 98-106"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autistic trait severity in early schizophrenia: Role in subjective quality of life and social functioning","authors":"Ayumu Wada ,&nbsp;Risa Yamada ,&nbsp;Yuji Yamada ,&nbsp;Chika Sumiyoshi ,&nbsp;Ryota Hashimoto ,&nbsp;Junya Matsumoto ,&nbsp;Akiko Kikuchi ,&nbsp;Ryotaro Kubota ,&nbsp;Makoto Matsui ,&nbsp;Kana Nakachi ,&nbsp;Chinatsu Fujimaki ,&nbsp;Leona Adachi ,&nbsp;Andrew Stickley ,&nbsp;Naoki Yoshimura ,&nbsp;Tomiki Sumiyoshi","doi":"10.1016/j.schres.2024.12.003","DOIUrl":"10.1016/j.schres.2024.12.003","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive impairment is a cardinal feature in patients with schizophrenia and leads to poor social functioning. Recently, the treatment of schizophrenia has evolved to include the goal of improving quality of life (QoL). However, most of the factors influencing subjective QoL are unknown. Autistic traits have been shown to co-occur with various psychiatric conditions including schizophrenia. Hence, the present study aimed to investigate whether cognitive function and autistic trait severity are associated with social functioning and subjective QoL in patients with early schizophrenia.</div></div><div><h3>Methods</h3><div>Data were analyzed from 183 outpatients diagnosed with early schizophrenia in Tokyo, Japan. Information was obtained on neurocognition with the Japanese version of the Brief Assessment of Cognition in Schizophrenia. Autistic trait severity was assessed using the Autism Spectrum Quotient (AQ), while social functioning was measured with the Specific Levels of Functioning Scale Japanese version. Information was obtained on subjective QoL with the Subjective Well-being under Neuroleptic drug treatment Short form, Japanese version. Multiple regression analysis was used to examined associations.</div></div><div><h3>Results</h3><div>In an analysis adjusted for demographic characteristics (age, sex and education), both autistic trait severity (<em>β</em> = -0.56, <em>p</em> &lt; 0.01) and neurocognitive function (<em>β</em> = 4.37, <em>p</em> &lt; 0.01) were significantly associated with social function. On the other hand, only autistic trait severity made a significant contribution to the prediction of subjective QoL (<em>β =</em> -1.79, <em>p</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>The results of this study suggest that efforts to detect and treat cognitive impairment and comorbid autistic trait in early schizophrenia may be important for improving social functioning and subjective QoL in this population. In particular intervention that targets autistic trait severity seems to be key to achieving personal recovery in patients with schizophrenia.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"275 ","pages":"Pages 131-136"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disentangling the topological symptom structure of schizophrenia: A network analysis","authors":"Jingjing Li ,&nbsp;Lijuan Pang ,&nbsp;Fang Liu ,&nbsp;Zhe Lu ,&nbsp;Yu Zhang ,&nbsp;Yongfeng Yang ,&nbsp;Xue Li ,&nbsp;Qiushi Hu ,&nbsp;Keju Su ,&nbsp;Yishao Chen ,&nbsp;Yan Zhang ,&nbsp;Fangfang Zhao ,&nbsp;Xueqin Song ,&nbsp;Gangrui Hei","doi":"10.1016/j.schres.2024.12.002","DOIUrl":"10.1016/j.schres.2024.12.002","url":null,"abstract":"<div><h3>Background and hypothesis</h3><div>The Positive and Negative Syndrome Scale (PANSS), comprehensively assesses schizophrenia severity. While network analyses of schizophrenic symptoms have yielded inconsistent results, components of disorganized thought consistently rank high in centrality. The present study aims to explore the centrality of disorganized thought across patient subgroups and its potential as a treatment target. We hypothesize that disorganized thought will emerge as a central feature in the symptom network across different patient populations.</div></div><div><h3>Study design</h3><div>We conducted a network psychometric analysis on data from 1435 schizophrenia patients, stratified into four groups based on family history and sex. Local and global network properties, including centrality, clustering coefficient, degree, density, and community detection, were investigated. Network comparisons were performed across groups, and results were validated using an independent dataset.</div></div><div><h3>Study results</h3><div>Disorganized thought emerged as the most central factor in Marder 5-factor model, maintaining stability across family history and sex differences. While family history did not significantly impact symptom structures (Females: M = 0.2, <em>P</em> = 0.4; S = 0.4, <em>P</em> = 0.7; Males: M = 0.2, <em>P</em> = 0.7; S = 0.1, <em>P</em> = 0.9), significant differences were observed between male and female symptom structures (Positive family history: M = 0.3, <em>P</em> &lt; 0.05; Negative family history: M = 0.3, <em>P</em> &lt; 0.01). The centrality and high stability of disorganized thought were further confirmed in the validation dataset.</div></div><div><h3>Conclusions</h3><div>The consistent centrality of disorganized thought across different patient subgroups suggests its potential as a key treatment target for schizophrenia.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"275 ","pages":"Pages 115-122"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between maternal schizophrenia and risk of serious asthma exacerbations in childhood","authors":"J.G. Pouget ,&nbsp;E. Cohen ,&nbsp;J.G. Ray ,&nbsp;A.S. Wilton ,&nbsp;H.K. Brown ,&nbsp;N.R. Saunders ,&nbsp;C.L. Dennis ,&nbsp;A.C. Holloway ,&nbsp;K.M. Morrison ,&nbsp;G.E. Hanley ,&nbsp;T.F. Oberlander ,&nbsp;A. Bérard ,&nbsp;K. Tu ,&nbsp;L.C. Barker ,&nbsp;S.N. Vigod","doi":"10.1016/j.schres.2024.11.008","DOIUrl":"10.1016/j.schres.2024.11.008","url":null,"abstract":"<div><h3>Background and hypothesis</h3><div>While maternal schizophrenia is linked to chronic childhood medical conditions, little is known about the risk of acute asthma exacerbations among children whose mothers have schizophrenia. This population-based study used health data for all of Ontario, Canada to evaluate whether having a mother with schizophrenia was associated with increased risk of asthma exacerbations.</div></div><div><h3>Study design</h3><div>The study cohort included 385,989 children diagnosed with asthma from age 2 years onward, followed from the time of their asthma diagnosis up to a maximum of age 19 years. Children whose biological mother was diagnosed with schizophrenia prior to the child's asthma diagnosis (<em>n</em> = 1407) were compared children whose mother was not (<em>n</em> = 384,582). Study outcomes were asthma-related hospitalization, and separately, asthma-related emergency department (ED) visit, each up to a maximum child age of 19 years. First exacerbations were evaluated using Cox proportional hazards models, and recurrent exacerbations by Andersen-Gill regression, adjusted for covariates.</div></div><div><h3>Study results</h3><div>First hospitalization for an asthma exacerbation occurred in 76 (6.9 per 1000 person-years) vs. 19,679 (5.4 per 1000 person-years) children with and without maternal schizophrenia (adjusted hazard ratio [aHR] 1.21, 95 % CI 0.97–1.51). For first asthma-related ED exacerbations, the rates were 25.1 vs. 20.7 per 100 person-years (aHR 1.06, 95 % CI 0.93–1.21). The adjusted rate ratio (aRR) for recurrent hospitalizations for asthma exacerbations was 1.27 (95 % CI 0.98–1.66), and 1.11 (95 % CI 0.94–1.31) for recurrent asthma-related ED exacerbations.</div></div><div><h3>Conclusions</h3><div>This study did not observe meaningful differences in acute care utilization for asthma exacerbations among children whose biological mothers had schizophrenia.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"275 ","pages":"Pages 123-130"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlights January","authors":"","doi":"10.1016/S0920-9964(25)00014-3","DOIUrl":"10.1016/S0920-9964(25)00014-3","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"275 ","pages":"Page A1"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does shame mediate the influence of trauma on psychosis? A systematic review and meta-analytic structural equation modelling approach","authors":"Kimberley Davies ,&nbsp;Julia M. Lappin ,&nbsp;Nancy Briggs ,&nbsp;Sophie Isobel ,&nbsp;Zachary Steel","doi":"10.1016/j.schres.2024.12.008","DOIUrl":"10.1016/j.schres.2024.12.008","url":null,"abstract":"<div><h3>Background</h3><div>Meta-analytic evidence has linked shame separately to both potentially traumatic events (PTEs) and psychosis, but the influence of shame on the relationship between PTEs and psychosis has not yet been examined. This study used meta-analytic structural equation modelling (MASEM) to examine whether shame plays a mediatory role between PTEs and experiences of psychosis.</div></div><div><h3>Methods</h3><div>A nested search was conducted within a previous systematic review on psychosis and shame to identify articles that contained a measure of PTEs. Included studies reported a quantitative association between psychosis and shame, and additionally a quantitative relationship between either i) PTEs and psychosis; or ii) PTEs and shame.</div></div><div><h3>Findings</h3><div>Of the 40 articles initially included, 14 met criteria and 13 were included in the analyses. Overall, shame partially mediated the relationship between PTE's and psychosis, observed through a significant indirect effect (β = 0.15, 95 % CI: 0.11–0.19) and a reduction in the direct path that remained significant (β = 0.13, 95 % CI: 0.06–0.20). Indirect paths through shame between childhood PTEs and psychosis (β = 0.07, 95 % CI: 0.03–0.11), and between lifespan PTEs and psychosis (β = 0.09, 95 % CI: 0.03–0.11), were both small but significant. Both direct paths remained significant, suggesting that shame acts a partial mediator for both types of PTE.</div></div><div><h3>Conclusions</h3><div>Shame is one path through which potentially traumatic events may influence the experience of psychosis and should be considered alongside other affective types in future modelling of psychosis. Qualitative research may aid further understanding of the mechanisms by which shame operates in this relationship.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"275 ","pages":"Pages 87-97"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The long-lasting impact of high-intensity training via collaborative care in patients with schizophrenia: A 5-year follow-up study","authors":"Mathias Forsberg Brobakken ,&nbsp;Mona Nygård ,&nbsp;Ismail Cüneyt Güzey ,&nbsp;Gunnar Morken ,&nbsp;Eivind Wang","doi":"10.1016/j.schres.2024.12.012","DOIUrl":"10.1016/j.schres.2024.12.012","url":null,"abstract":"<div><div>Although exercise is medicine for outpatients with schizophrenia, it is unclear if one-year adherence-supported exercise leads to a “<em>tipping point</em>”, at which the exercise becomes a routine manifested as life-long training in the patient group.</div></div><div><h3>Methods</h3><div>Forty-eight outpatients (28 men/20 women: 35 ± 11 (mean ± SD) years) with schizophrenia (ICD-10: F20–29) were randomised to: 1) collaborative care group (TG), performing aerobic interval (AIT; 4 × 4-min treadmill walking/running at ∼90 % peak heart rate) and leg press maximal strength training (MST; 4 × 4 repetitions at ∼90 % maximal strength [1RM]) 2d·wk.⁻¹ for 1-year, supported by transportation and training supervision; or 2) control group (CG). Peak oxygen uptake (V̇O_2peak) and walking work efficiency were measured directly along with scaled 1RM/power, anthropometry, blood pressure, and blood samples at inclusion, 1-year, and 5-years post-intervention.</div></div><div><h3>Results</h3><div>The TG increased V̇O_2peak (11 %, <em>p</em> &lt; .01), scaled 1RM (40 %, <em>p</em> &lt; .001), and power (26 %, p &lt; .001) compared to CG after 1-year. At follow-up, no intergroup differences in these factors were observed (all <em>p</em> &gt; .05). Both groups improved walking work efficiency (TG: 11 %; CG: 18 %; both <em>p</em> &lt; .05) after 1-year (no intergroup difference, p &gt; .05), but not at follow-up (both p &gt; .05). At follow-up, HDL (high-density lipoprotein)-cholesterol (−15 %, <em>p</em> &lt; .01) and glucose (26 %, p &lt; .01) decreased/increased(respectively) more in the TG than CG. No other intergroup differences were observed in anthropometry or blood samples.</div></div><div><h3>Conclusion</h3><div>1-year adherence-supported high-intensity training improves V̇O_2peak, 1RM, and power in outpatients with schizophrenia. However, the improvements in these factors key to longevity are not maintained after 5 years. These findings highlight the importance of long-lasting cost-efficient adherence support, ultimately affecting the population's prognosis.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"275 ","pages":"Pages 156-165"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insight and suicidality in first-episode psychosis: The mediating role of depression","authors":"Sümeyra N. Tayfur ,&nbsp;Zhiqian Song ,&nbsp;Fangyong Li ,&nbsp;Hadar Hazan ,&nbsp;Toni Gibbs-Dean ,&nbsp;Deepa Purushothaman ,&nbsp;Sneha Karmani ,&nbsp;Javier Ponce Terashima ,&nbsp;Cenk Tek ,&nbsp;Vinod H. Srihari","doi":"10.1016/j.schres.2024.12.013","DOIUrl":"10.1016/j.schres.2024.12.013","url":null,"abstract":"<div><div>Understanding the relationship between insight, depression, and suicidality in first-episode psychosis (FEP) is crucial for improving clinical outcomes and preventing suicide during early treatment stages. This longitudinal cohort study examined 264 participants enrolled in coordinated specialty care (CSC) services for FEP to investigate how insight and depression at admission impact suicidality at 6 and 12 months, assess the mediating role of depression at admission between insight and suicidality, and evaluate the persistence of depression over time. Regression analyses assessed the relationships among these variables, while mediation analyses explored the mediating effect of depression at admission. Significant predictors of suicidality at 6 months were insight (OR 0.71, 95 % CI: 0.53–0.94), depression (OR 5.40, 95 % CI: 2.45–12.61), and previous suicide attempts (OR 2.91, 95 % CI: 1.21–7.00). At 12 months, insight (OR 0.70, 95 % CI: 0.52–0.92) and depression (OR 2.82, 95 % CI: 1.26–6.50) remained significant. Depression at admission mediated 27.32 % of the effect of insight on suicidality at 6 months and 19.76 % at 12 months. Despite a general decrease in depression, a subset of participants remained persistently depressed. The study highlights the significant mediating role of depression at admission in the relationship between insight and suicidality, identifying it as the strongest predictor of suicidality. Early detection and treatment of depression in FEP should be prioritized, and further research should focus on targeted interventions within CSC.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"275 ","pages":"Pages 189-195"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schizotypal dimensions by migrant status in the general population: An exploratory study","authors":"Franck Schürhoff ,&nbsp;Baptiste Pignon ,&nbsp;Mohamed Lajnef ,&nbsp;Grégoire Baudin ,&nbsp;Jean-Romain Richard ,&nbsp;Hélène Charreire ,&nbsp;Andrea Tortelli ,&nbsp;Andrei Szöke","doi":"10.1016/j.schres.2024.12.014","DOIUrl":"10.1016/j.schres.2024.12.014","url":null,"abstract":"<div><div>Migrant status and ethnic minority background have been associated with increased risk for psychosis. However, it remains unclear if such association exists with subclinical forms of psychosis. In two general population samples, totaling 460 subjects, we investigated whether migrant status and/or ethnicity predict self-reported positive, negative and/or disorganized dimensions of psychosis (as measured by the SPQ-B). In comparison to the reference population, we observed higher scores in the negative dimension among both first and second-generation migrants as well as in some ethnic minority groups (particularly North Africa and French overseas). Our findings highlight the need to understand the mechanisms underlying this association between negative schizotypal traits and migrant/ethnic minority status. The fact that migration/ethnicity are associated with both psychotic disorders and subclinical manifestations of psychosis also support the psychosis continuum theory. The higher rates of negative schizotypal traits in these populations underscores the necessity for tailored policies and interventions to enhance mental health and prevent the transition to psychosis in these subgroups.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"275 ","pages":"Pages 208-216"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}