Schizophrenia Research最新文献

{"title":"Issue highlights","authors":"","doi":"10.1016/S0920-9964(25)00107-0","DOIUrl":"10.1016/S0920-9964(25)00107-0","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Page A1"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary: Examining language and selfhood in hallucinations","authors":"Lena Palaniyappan , Oliver Delgaram-Nejad","doi":"10.1016/j.schres.2025.02.014","DOIUrl":"10.1016/j.schres.2025.02.014","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 42-43"},"PeriodicalIF":3.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schizophrenia spectrum disorders with comorbid panic: A systematic review","authors":"André Barciela Veras ,&nbsp;Karyson Macruz Ribeiro ,&nbsp;Clayton Peixoto ,&nbsp;Natia Horato ,&nbsp;Jeffrey Paul Kahn ,&nbsp;Antonio Egidio Nardi","doi":"10.1016/j.schres.2025.02.005","DOIUrl":"10.1016/j.schres.2025.02.005","url":null,"abstract":"<div><h3>Background</h3><div>The classical description of panic psychosis is characterized by existence of paroxysmal panic anxiety concurrent with auditory hallucinations or paranoid delusions. Although there is a high prevalence of panic comorbidity in schizophrenia, there remains much uncertainty among clinicians.</div></div><div><h3>Aims</h3><div>We aim to describe the psychopathological manifestations and pathogenetic factors of subjects with schizophrenia spectrum disorders comorbid with panic disorder. Adequate diagnosis and treatment of these conditions can produce significant amelioration of co-morbidities and psychotic symptoms.</div></div><div><h3>Methods</h3><div>Studies included in the review were selected through electronic search in these databases: Medical Literature databases and Retrieval System Online (Medline), Latin American and Caribbean Health Sciences (LILACS) and the Cochrane Library. Included were clinical studies in which schizophrenia spectrum disorder subjects had their diagnoses confirmed according to criteria from systematized manuals, and who also were evaluated with standardized scales for psychiatric symptomatology (psychosis, diagnosis of panic disorder or panic attacks, anxiety and general symptoms).</div></div><div><h3>Results</h3><div>We found a total of 449 results from electronic searches. Only twenty-five studies fully met the inclusion criteria for this review. Two main methodological approaches were identified: 1. Clinical studies which specifically focused on patients with Schizophrenia Spectrum Disorders (SSD) with comorbid Panic Disorder (PD) (<em>N</em> = 11); 2. Clinical studies which examined broader groups of SSD patients (<em>N</em> = 13) for Panic symptoms.</div></div><div><h3>Conclusion</h3><div>Comparative studies show that SSD patients with PD comorbidity usually have more severe psychotic symptomatology, more depressive symptoms, more suicide ideation, earlier onset, and worse outcome. Correlation analysis confirmed the association of panic with more depressive symptoms, early onset, and worse functioning. In addition, other risk factors such as early trauma, hypovitaminosis D and a cross familiar risk are considered.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 33-41"},"PeriodicalIF":3.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are all antipsychotic dose reduction trials in stable schizophrenia the same?","authors":"Hiroyoshi Takeuchi","doi":"10.1016/j.schres.2025.02.007","DOIUrl":"10.1016/j.schres.2025.02.007","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 31-32"},"PeriodicalIF":3.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARPEP, a rapid-learning healthcare system of early intervention services for psychosis in Quebec, Canada: Feasibility, acceptability and early impacts","authors":"Amal Abdel-Baki ,&nbsp;Manuela Ferrari ,&nbsp;Annie Leblanc ,&nbsp;Camille Arbaud ,&nbsp;Daniel Rabouin ,&nbsp;Marc-André Roy ,&nbsp;Srividya N. Iyer","doi":"10.1016/j.schres.2025.02.001","DOIUrl":"10.1016/j.schres.2025.02.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite growing interest in learning health systems, their application and evaluation in mental health have been scarce. This study aimed to evaluate the feasibility, acceptability and early impacts of SARPEP, a rapid learning healthcare system (RLHS) for early intervention services for psychosis in Quebec, Canada.</div></div><div><h3>Methods</h3><div>SARPEP comprised technology-supported monitoring of program and patient outcomes, feedback and capacity-building. It involved 11 services (128 professionals, 1700+ patients). We descriptively analyzed quantitative data on the RE-AIM framework (Reach, Effectiveness, Adoption, Implementation, Maintenance) collected in the first two years.</div></div><div><h3>Results</h3><div><em>Reach</em>: Patient and family partners, all programs (clinicians, managers), government representatives and the provincial early psychosis association agreed to co-design and implement all SARPEP components. <em>Effectiveness</em>: Data informed program- and provincial-level decision-making. Some quality indicators (e.g., timely access) improved over time. 80 % of youth were satisfied with services. <em>Adoption</em>: All programs collected data on satisfaction and quality, with data collection improving over time. Eight programs and all stakeholder groups participated in most community-of-practice sessions. <em>Implementation</em>: The time required for data collection and providing feedback decreased over time. SARPEP offered rapid, flexible support; tools; and a community of practice that facilitated collecting data, and monitoring and improving practices. <em>Maintenance</em>: All programs remained in SARPEP post study.</div></div><div><h3>Conclusion</h3><div>Involving all stakeholders, RLHSs can be deployed, adopted, and maintained in mental healthcare and increase the measurement of practices and quality improvement efforts. Strategies are needed to increase the completion of patient-reported measures and to rigorously evaluate the RLHS' effectiveness in improving service quality and outcomes.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 20-30"},"PeriodicalIF":3.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Tribute to Timothy J. Crow: 1938–2024","authors":"Lynn E. DeLisi","doi":"10.1016/j.schres.2025.01.011","DOIUrl":"10.1016/j.schres.2025.01.011","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in the relationship between the vascular endothelial growth factor and cognition in drug-naïve schizophrenia","authors":"Xiaoxiao Sun ,&nbsp;Ying Xu ,&nbsp;Yanqing Wu ,&nbsp;Meijuan Li ,&nbsp;Yuying Qiu ,&nbsp;Qiao Su ,&nbsp;Jiayue Wang ,&nbsp;Jie Li ,&nbsp;Fuqiang Mao","doi":"10.1016/j.schres.2025.02.002","DOIUrl":"10.1016/j.schres.2025.02.002","url":null,"abstract":"<div><h3>Background</h3><div>This study investigates the sex-specific relationship between plasma Vascular Endothelial Growth Factor (VEGF) levels and cognitive performance in drug-naïve schizophrenia (DNS) patients, focusing on longitudinal changes.</div></div><div><h3>Methods</h3><div>A total of 175 DNS patients and 80 healthy controls (HCs) completed the MATRICS Consensus Cognitive Battery (MCCB). VEGF levels were measured via ELISA, and DNS patients were assessed using the Positive and Negative Syndrome Scale (PANSS). Partial correlations and multiple linear regressions were used to evaluate the relationships between VEGF, cognition, and symptom severity, adjusting for demographic and clinical factors.</div></div><div><h3>Results</h3><div>Female DNS patients showed greater cognitive impairments than female HCs (all <em>P</em> &lt; 0.05), while male DNS patients had specific deficits in Attention/Vigilance (<em>P</em> = 0.027) and Working Memory (<em>P</em> = 0.002). Among females, baseline VEGF levels were inversely correlated with psychotic symptoms, including PANSS Positive symptom scores (<em>r</em> = −0.281) and PANSS total scores (<em>r</em> = −0.224). Additionally, baseline VEGF levels were positively associated with cognitive performance, including Processing Speed (<em>r</em> = 0.302), Neurocognition (<em>r</em> = 0.193), and the MCCB total score (<em>r</em> = 0.201). In males, baseline VEGF levels showed a trend toward predicting less severe negative symptoms at the 8-week (<em>β</em> = −0.42, <em>P</em> = 0.060), though not statistically significant.</div></div><div><h3>Conclusion</h3><div>VEGF may protect cognition in female DNS patients through neuroprotective or anti-inflammatory mechanisms. Higher VEGF levels in females were linked to better cognition and milder symptoms over time. These findings suggest VEGF as a potential sex-specific biomarker for schizophrenia, warranting further investigation.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 9-17"},"PeriodicalIF":3.6,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socially relevant affective learning in psychosis: Relations to deficits in motivation and pleasure and cognitive ability","authors":"Ryan D. Orth ,&nbsp;Imani L. Todd ,&nbsp;Kristen R. Dwyer ,&nbsp;Melanie E. Bennett ,&nbsp;Jack J. Blanchard","doi":"10.1016/j.schres.2025.02.003","DOIUrl":"10.1016/j.schres.2025.02.003","url":null,"abstract":"<div><div>Negative symptoms are common in psychotic disorders and significantly contribute to functional impairment. Deficits in reward processing and memory have been implicated as important factors which contribute to negative symptoms, leading to speculation that deficits in learning and memory of socially relevant information may be particularly important. Previous work has also found poorer learning of positive social behavior associations in psychotic disorders, but limitations have prevented an examination of symptom correlates of this diminished learning. In the present study, we used an updated social affective learning task to examine whether diminished accuracy in learning the affective value of others was related to motivation and pleasure negative symptoms as well as cognitive deficits. Results indicated that participants were able to use both positive and negative behavioral information to generate accurate socially evaluative perceptions. Results also demonstrated that reduced accuracy of learning from positive behavioral information was related to greater motivation and pleasure symptoms and cognitive deficits, including working memory, while reduced accuracy of learning from negative behavioral information was only related to cognitive deficits across multiple domains. When controlling for cognition, motivation and pleasure symptoms were no longer related to positive affective learning, but working memory remained related to learning when controlling for motivation and pleasure symptoms. These findings underscore the role of diminished positive affective learning in negative symptoms and suggest that poorer learning of the positive value of others may be one pathway through which cognitive deficits lead to reduced reward anticipation, defeatist performance beliefs, and negative symptoms.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 1-8"},"PeriodicalIF":3.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sub-clinical systemic inflammation as a determinant of admission duration in psychosis","authors":"Graham Blackman ,&nbsp;James DeLaney ,&nbsp;James H. MacCabe ,&nbsp;Golam Khandaker ,&nbsp;Philip McGuire","doi":"10.1016/j.schres.2024.12.010","DOIUrl":"10.1016/j.schres.2024.12.010","url":null,"abstract":"<div><h3>Background</h3><div>The immune system may play an important role in the aetiology of psychotic disorders and there is increasing interest in the relationship between immune markers and clinical outcomes in psychosis. The present study investigated whether subclinical systemic inflammation was associated with length of stay in individuals with psychosis admitted to a psychiatric hospital. We tested the hypothesis that a higher level of subclinical systemic inflammation, as measured by the neutrophil-to-lymphocyte ratio (NLR) would be associated with a longer period in hospital.</div></div><div><h3>Method</h3><div>Retrospective cohort study based on electronic health records. We included patients with a psychosis spectrum disorder (ICD10: F20-F29) who had a routine blood test upon being admitted to a psychiatric hospital within the South London and Maudsley NHS Foundation Mental Health Trust, London, UK between 2013 and 2019. Multiple linear regression was used to determine the association between the NLR at the time of admission and the duration of the corresponding hospital stay, adjusting for covariables.</div></div><div><h3>Results</h3><div>Data from 1683 individuals with psychosis were analyzed. The median admission duration was 31 days (interquartile range = 48 days). Higher neutrophil-to-lymphocyte ratio (NLR) was significantly associated with longer admission (<span><math><mi>B</mi></math></span> = 0.07, <em>p</em> <em>&lt;</em> 0.003) after adjusting for covariates.</div></div><div><h3>Conclusion</h3><div>An association between a NLR and a longer admission, whilst controlling for relevant covariables, was observed highlighting the potential utility of inflammatory markers as prognostic marker in clinical settings.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 17-23"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional intelligence as a predictor of functional outcomes in psychotic disorders","authors":"Jennifer M. Blank ,&nbsp;Roman Kotov ,&nbsp;Katherine G. Jonas ,&nbsp;Wenxuan Lian ,&nbsp;Elizabeth A. Martin","doi":"10.1016/j.schres.2025.01.005","DOIUrl":"10.1016/j.schres.2025.01.005","url":null,"abstract":"<div><div>Psychotic disorders are associated with significant impairment in psychosocial functioning, yet mechanisms associated with this impairment remain poorly understood. Emotional intelligence, a component of social cognition, is associated with psychosocial functioning in this population. However, prior work has used relatively small samples, reported inconsistent relations between functioning domains and emotional intelligence, and inconsistently considered negative symptoms. To address these limitations, we examined the predictive ability of emotional intelligence on functional outcomes using a five-year longitudinal design. We used a large sample of individuals with and without psychotic disorder diagnoses (N = 324), a performance-based measure of emotional intelligence, and three measures of functioning (i.e., social performance, assessor-rated social and occupational functioning, self-rated functioning in independent living). Results revealed individuals diagnosed with a psychotic disorder have lower emotional intelligence than those without a history of psychosis. Emotional intelligence was associated with social performance and social and occupational functioning in both those with and without a history of psychosis. In those diagnosed with a psychotic disorder, emotional intelligence and negative symptoms better predict social performance (<span><math><mi>β</mi></math></span>_Emotional = 0.36, R²_delta = 0.09) and social and occupational functioning (<span><math><mi>β</mi></math></span>_Emotional = 0.21, R² = 0.03), but not self-rated functioning in independent living (<span><math><mi>β</mi></math></span>_Emotional = −0.08, R²_delta = 0.00), as compared to negative symptoms alone. Overall, findings support the use of emotional intelligence as a longitudinal predictor of social and occupational outcomes above and beyond negative symptoms alone. This work highlights potential, specific intervention targets for individuals with psychotic disorders.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 97-105"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}