Schizophrenia Research最新文献

{"title":"The day-to-day influence of trauma exposure and sleep dysfunction on everyday stress in youth at familial high-risk for psychotic disorders","authors":"Elizabeth A. Haudrich ,&nbsp;Emily K. Burns ,&nbsp;Tina Gupta ,&nbsp;Gretchen L. Haas ,&nbsp;Leslie E. Horton","doi":"10.1016/j.schres.2024.10.024","DOIUrl":"10.1016/j.schres.2024.10.024","url":null,"abstract":"<div><div>Cumulative research finds that exposure to childhood trauma, sleep dysfunction, and high stress levels are prevalent in youth diagnosed with and at-risk for psychotic disorders. However, few studies have investigated the association between nightly sleep and moment-to-moment stress in youth who are at familial high-risk (FHR) for psychotic disorders with varying levels of exposure to childhood trauma. The current study examined the day-to-day associations between trauma severity, nightly sleep duration, and next-day momentary stress in 19 FHR and 19 non-psychiatric youth (ages 13–19 years, 66 % girls). Ecological Momentary Assessment was used to assess these variables across three longitudinal timepoints (baseline, 6-months, and 12-months). The FHR group reported greater trauma severity and shorter sleep duration than the non-psychiatric group. In the whole sample, trauma severity and reduced sleep duration were associated with next-day momentary stress. While group status did not moderate the association between sleep duration and next-day momentary stress, group status did moderate the positive association between trauma severity and next-day momentary stress, showing that the association was specific to the non-psychiatric group. Lastly, the effect of nightly sleep duration on next-day momentary stress was significant and negative, but only at low levels of trauma severity for the whole sample. Findings offer preliminary insights into the associations between trauma severity, sleep duration, and momentary stress. Furthermore, this design can provide a foundation for future research examining environmental and psychosocial risk factors that contribute to symptom progression and prognosis of youth who are genetically vulnerable to psychosis.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"274 ","pages":"Pages 535-544"},"PeriodicalIF":3.6,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-designing technology to improve psychological therapy for psychosis: SloMo, a blended digital therapy for fear of harm from others","authors":"Amy Hardy ,&nbsp;Kathryn M. Taylor ,&nbsp;Amy Grant ,&nbsp;Louie Christie ,&nbsp;Lucy Walsh ,&nbsp;Thomas Gant ,&nbsp;Rama Gheerawo ,&nbsp;Anna Wojdecka ,&nbsp;Adrian Westaway ,&nbsp;Alexa Münch ,&nbsp;Philippa Garety ,&nbsp;Thomas Ward","doi":"10.1016/j.schres.2024.11.004","DOIUrl":"10.1016/j.schres.2024.11.004","url":null,"abstract":"<div><div>Digital technology is positioned as a potential solution to improving access, experience, and outcomes of psychological therapies for psychosis. Digital solutions need to be fit for purpose and tailored to context to deliver real world benefits. To address this, co-production is often used, where stakeholder involvement informs intervention development. However, co-production in clinical research tends to limit involvement to refining previously identified solutions to known problems. This is not an optimal approach to innovation and risks maintaining inequities. An alternative is inclusive co-design, where the needs of a diverse range of people are collaboratively explored using ethnography, and solutions to address these iteratively developed through user testing. In healthcare, we propose an evidence-based approach to co-design (‘hybrid waterfall-agile’) is required. This is because ‘agile’ exploration of needs and solutions is necessarily constrained by clinical guidelines and regulatory requirements (the ‘waterfall’). This paper provides an overview of evidence-based co-design. We use the example of SloMo, a blended digital therapy for paranoia. We describe our transdisciplinary team collaboration and how this facilitates inclusive lived experience involvement. Our therapy development method is outlined, illustrated by reflections from lived experience team members. Iterative divergent (‘zooming out’) and convergent (‘honing in’) cycles are used to co-design therapy functionality, aesthetics, interactions, and content, supported by stakeholder engagement. We conclude by reflecting on common challenges including sustaining lived experience involvement, adherence to evidence base, regulatory compliance, funding, and project management. Recommendations for navigating these obstacles are provided, with the aim of encouraging innovation in mental healthcare for psychosis.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"274 ","pages":"Pages 526-534"},"PeriodicalIF":3.6,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network analysis of psychotic symptoms in schizophrenia","authors":"Hong Cai ,&nbsp;Bing Shen ,&nbsp;Jian-Xiong Long ,&nbsp;Xiao-Lan Huang ,&nbsp;Jia-Le Li ,&nbsp;Zhi-Cheng Zhong ,&nbsp;Yu-Hua Wei ,&nbsp;Li Su","doi":"10.1016/j.schres.2024.11.002","DOIUrl":"10.1016/j.schres.2024.11.002","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia with a wide range of psychotic symptoms which indicate the severity of disorders, risk of relapse, frequency and duration of hospitalization, and decreases social and occupational function. In clinical practice, Positive and Negative Systems Scale always used for assessment the severity of psychotic symptoms of patients with schizophrenia. This network analysis explores the inter-relationship of psychotic symptoms of patients with based on Positive and Negative Systems Scale (PANSS).</div></div><div><h3>Methods</h3><div>The psychotic symptoms of the patients with schizophrenia were assessed by psychiatrist using PANSS when the first day in hospitalization. The network structure of psychotic symptoms was modelled with a graph and characterized using “Expected Influence” and “Bridge Expected Influence” as influential indices in the symptom network. Network stability was tested using a case-dropping bootstrap procedure. Network Comparison Test (NCT) was conducted to examine whether network characteristics differed on the basis of gender.</div></div><div><h3>Results</h3><div>A total of 799 patients with schizophrenia were included. The mean age of the included participants was 39.51(standard deviation (SD)13.93). The main finding of the study was Preoccupation, Emotional instability and Anxiety were the most influential psychotic symptoms, while Active social avoidance, Emotional instability and Preoccupation were the most bridge influential psychotic symptoms within the interpret-able level of influential in the network. Gender did not significantly affect the overall network structure.</div></div><div><h3>Conclusion</h3><div>This influential (Preoccupation, Emotional instability and Anxiety) and bridge influential symptoms (Active social avoidance, Emotional instability and Preoccupation) dimension could be addressed in treatment target and treatment response for the patients with schizophrenia.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"274 ","pages":"Pages 501-507"},"PeriodicalIF":3.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free-water imaging in subcortical gray matter in schizophrenia patients with persistent auditory verbal hallucinations","authors":"Jinguang Li ,&nbsp;Jingqi He ,&nbsp;Honghong Ren ,&nbsp;Zongchang Li ,&nbsp;Xiaoqian Ma ,&nbsp;Liu Yuan ,&nbsp;Lijun Ouyang ,&nbsp;Aijun Liao ,&nbsp;Huiqing Peng ,&nbsp;Ying He ,&nbsp;Jinsong Tang ,&nbsp;Xiaogang Chen","doi":"10.1016/j.schres.2024.10.028","DOIUrl":"10.1016/j.schres.2024.10.028","url":null,"abstract":"<div><div>Subcortical gray matter (SGM) is increasingly linked to the pathophysiology of schizophrenia, specifically auditory verbal hallucinations (AVHs). However, few studies have been conducted on the role of extracellular free-water (FW) and white matter microstructural abnormalities in AVHs within the SGM using the free water elimination technique. We conducted a comprehensive investigation of macroscopic volume, FW, and white matter microstructure in the SGM of 60 schizophrenia patients with persistent AVHs (p-AVH), 36 patients no AVH history (n-AVH), and 43 healthy control participants (HC). No macroscopic volume abnormalities were found in the p-AVH or n-AVH groups. However, abnormalities in both FW and microstructures were detected in multiple SGM structures of individuals with schizophrenia. Importantly, unlike the n-AVH group, the p-AVH group exhibited FW and microstructure abnormalities in the bilateral caudate that correlated with AVH severity. Our findings suggest that regardless of the presence of AVHs, FW and microstructure abnormalities in the SGM are more pronounced than macroscopic volume abnormalities in patients with schizophrenia. The bilateral caudate may be a key factor in the mechanisms underlying AVHs. Additionally, normal FW and microstructure in the bilateral caudate may be a notable characteristic of n-AVH patients.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"274 ","pages":"Pages 517-525"},"PeriodicalIF":3.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscarinic deficits - part of a cholinergic-dopaminergic- glutamatergic imbalance in schizophrenia?","authors":"Matcheri S. Keshavan ,&nbsp;Pegah Seif ,&nbsp;Rajiv Tandon","doi":"10.1016/j.schres.2024.11.001","DOIUrl":"10.1016/j.schres.2024.11.001","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"274 ","pages":"Pages 508-510"},"PeriodicalIF":3.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problematic gambling and psychotic-like experiences: Findings from Japan","authors":"Andrew Stickley ,&nbsp;Aya Shirama ,&nbsp;Risa Yamada ,&nbsp;Tomiki Sumiyoshi","doi":"10.1016/j.schres.2024.11.003","DOIUrl":"10.1016/j.schres.2024.11.003","url":null,"abstract":"<div><h3>Background</h3><div>Comparatively little is known about the association between problematic gambling and psychotic-like experiences (PLEs). This study examined the association among adults in the Japanese general population and whether this association differs between men and women.</div></div><div><h3>Methods</h3><div>Data were analyzed from 3701 individuals that were obtained in an online survey. Information on problematic gambling was assessed with the Japanese short version of the South Oaks Gambling Screen Revised (SOGS-R), while PLEs were measured with the PRIME Screen-Revised (PS-R). Logistic regression was used to examine associations.</div></div><div><h3>Results</h3><div>In an analysis adjusted for sociodemographic, self-rated health and mental health variables, problematic gambling was associated with significantly higher odds for PLEs (OR: 1.64, 95%CI: 1.07–2.50). When the analysis was stratified by sex, problematic gambling was significantly associated with PLEs in women (OR: 2.80, 95%CI: 1.33–5.89) but not men (OR: 1.32, 95%CI: 0.78–2.22) in the fully adjusted model. No effect modification by sex was found.</div></div><div><h3>Conclusion</h3><div>Problematic gambling is associated with higher odds for PLEs among adults in Japan. More research is now needed to determine which factors are associated with the co-occurrence of problematic gambling and PLEs and whether this comorbidity is associated with a higher risk for negative gambling-related and other outcomes.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"274 ","pages":"Pages 511-516"},"PeriodicalIF":3.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orientation-dependent contextual modulation of contrast in schizophrenia","authors":"Victor J. Pokorny ,&nbsp;Scott R. Sponheim ,&nbsp;Cheryl A. Olman","doi":"10.1016/j.schres.2024.10.021","DOIUrl":"10.1016/j.schres.2024.10.021","url":null,"abstract":"<div><h3>Introduction</h3><div>Schizophrenia is associated with weakened contextual modulation of visual contrast perception, which is generally predicted by population average neural firing rates in primary visual cortex (V1). We use high field fMRI and a novel task to assess V1-instrinsic and V1-extrinsic mechanisms of atypical contextual modulation in schizophrenia.</div></div><div><h3>Methods</h3><div>We examined the BOLD responses of individuals with schizophrenia (SCZ = 34), bipolar disorder (BP = 25), unaffected first-degree relatives of SCZ (SREL = 20), unaffected first-degree relatives of BP (BPREL = 13) and healthy controls (CON = 23). Participants were presented with near- and far-surrounds oriented at 20° and 70° relative to center gratings.</div></div><div><h3>Results</h3><div>We observed orientation-dependent modulation of V1 BOLD activation to near-surrounds across groups. In particular, the SCZ and CON groups showed significant orientation-dependent contextual modulation (Cohen's d_z SCZ = 0.56; CON = 0.63). Surprisingly, the direction of the modulation was opposite of predicted: greater BOLD activation for the condition that was expected to produce suppression.</div></div><div><h3>Conclusions</h3><div>Our results differ from previous reports: we observed successful orientation-dependent modulation of V1 activation in SCZ. Furthermore, our results suggest that spatial attention and figure-ground modulation may play an important role in determining the direction and magnitude of orientation-dependent modulation.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"274 ","pages":"Pages 492-500"},"PeriodicalIF":3.6,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-disturbance in schizophrenia: Updating the research and bridging the gaps","authors":"Amy M. Jimenez,&nbsp;Michael F. Green","doi":"10.1016/j.schres.2024.10.017","DOIUrl":"10.1016/j.schres.2024.10.017","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"274 ","pages":"Pages 489-491"},"PeriodicalIF":3.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The theoretical sensitivity of virtual assessment of catatonia","authors":"James Luccarelli ,&nbsp;Joshua Ryan Smith ,&nbsp;Stephan Heckers ,&nbsp;Gregory Fricchione ,&nbsp;Jo Ellen Wilson","doi":"10.1016/j.schres.2024.10.020","DOIUrl":"10.1016/j.schres.2024.10.020","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"274 ","pages":"Pages 486-488"},"PeriodicalIF":3.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma NGAL, not IFN-γ, predicts early treatment response in drug-naïve Chinese Han schizophrenia patients","authors":"Xiaoxiao Sun ,&nbsp;Meijuan Li ,&nbsp;Yuying Qiu ,&nbsp;Qiao Su,&nbsp;Jiayue Wang,&nbsp;Fuyou Bi,&nbsp;Jie Li","doi":"10.1016/j.schres.2024.10.025","DOIUrl":"10.1016/j.schres.2024.10.025","url":null,"abstract":"<div><h3>Background</h3><div>Early prediction of treatment efficacy can assist psychiatrists in optimizing personalized treatment strategies for drug-naïve schizophrenia patients. This study aimed to explore the predictive value of plasma concentrations of Interferon-γ (IFN-γ) and Neutrophil gelatinase-associated lipocalin (NGAL) in early treatment responses.</div></div><div><h3>Methods</h3><div>We conducted a longitudinal study involving 125 drug-naïve schizophrenia patients and 75 healthy controls. Plasma samples were collected and analyzed at baseline and after 8 weeks of treatment. Based on treatment outcomes, patients were classified as Responders (R, <em>n</em> = 84) or Non-responders (NR, <em>n</em> = 41).</div></div><div><h3>Results</h3><div>At baseline, schizophrenia patients showed significantly lower IFN-γ and NGAL concentrations compared to healthy controls. NGAL levels were notably lower in the NR group compared to the R group. After treatment, both IFN-γ and NGAL concentrations increased in all patients, with a marked rise in IFN-γ levels. NGAL concentration negatively correlated with the positive factor at baseline, adjusting for confounders such as age, BMI, smoking, and duration of untreated illness. Logistic regression analysis identified lower baseline NGAL concentrations as a predictor of poor early treatment response.</div></div><div><h3>Conclusion</h3><div>Pre-treatment plasma NGAL concentrations may serve as a potential biomarker for predicting early treatment response in drug-naïve Chinese Han schizophrenia patients. These findings highlight NGAL as a possible target for future therapeutic development in schizophrenia.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"274 ","pages":"Pages 457-463"},"PeriodicalIF":3.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}