Schizophrenia Research最新文献

{"title":"Comorbidity of anorexia nervosa and schizophrenia: A systematic review","authors":"Rachel M. Hechinger ,&nbsp;Kristin N. Javaras ,&nbsp;Kathryn Eve Lewandowski","doi":"10.1016/j.schres.2025.01.010","DOIUrl":"10.1016/j.schres.2025.01.010","url":null,"abstract":"<div><div>Research on the intersection between eating disorders and schizophrenia (SCZ) has mainly focused on binge eating, since increased appetite and metabolic side effects are common during antipsychotic use. However, the prevalence of restrictive eating and anorexia nervosa may be higher in people with SCZ than in the general population, and evidence suggests shared genetic liability for SCZ and anorexia nervosa (AN). The aim of this systematic review was to examine the prevalence, psychological and biological mechanisms, and theoretical underpinnings underlying the co-occurrence of AN and SCZ. We identified 40 articles that met inclusion criteria. Evidence suggested that the prevalence of AN in patients with SCZ is higher than would be expected in the general population; conversely, evidence regarding the prevalence of SCZ in AN was mixed. Psychological mechanisms underlying AN in people with SCZ fell into three categories: positive symptoms, negative symptoms, and atypical pathways. A limited literature generally supports the hypothesis of higher prevalence of AN in patients with SCZ, but there are few studies in this area. Studies of the prevalence of SCZ in AN yield more mixed findings, although these studies are also relatively small and few. Further, studies of both types tend to include only clinically ascertained samples, which limits the generalizability of findings beyond patients. Larger, better-designed studies may improve identification and treatment of people with co-occurring SCZ and AN.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 185-193"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 outbreak in a ward led three patients to discontinue clozapine due to neutropenia: Call for urgent considerations regarding clozapine regulation in Japan","authors":"Yuki Kikuchi ,&nbsp;Sota Ueno ,&nbsp;Bunichiro Onodera ,&nbsp;Hiroaki Tanifuji ,&nbsp;Hiroshi Komatsu ,&nbsp;Hiroaki Tomita","doi":"10.1016/j.schres.2025.01.024","DOIUrl":"10.1016/j.schres.2025.01.024","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 194-195"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clozapine discontinuation and rechallenge in suspected myocarditis: An analysis of seven cases","authors":"Laura Matheson,&nbsp;Randall F. White,&nbsp;Sharon S.F. Liu,&nbsp;Simon W. Rabkin,&nbsp;Chad A. Bousman,&nbsp;Reza Rafizadeh","doi":"10.1016/j.schres.2025.01.026","DOIUrl":"10.1016/j.schres.2025.01.026","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 202-204"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143300455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodevelopment within the first three years of life does not predict psychotic experiences at age 10: A prospective cohort study","authors":"María Hernández-Lorca ,&nbsp;Martin Køster Rimvall ,&nbsp;Jens Richardt Møllegaard Jepsen ,&nbsp;Julie B. Rosenberg ,&nbsp;Parisa Mohammadzadeh ,&nbsp;Birgitte Fagerlund ,&nbsp;Birte Glenthøj ,&nbsp;Bo Chawes ,&nbsp;Klaus Bønnelykke ,&nbsp;Bjørn H. Ebdrup ,&nbsp;Rebecca Kofod Vinding","doi":"10.1016/j.schres.2025.01.025","DOIUrl":"10.1016/j.schres.2025.01.025","url":null,"abstract":"<div><h3>Background</h3><div>Early childhood developmental delays and lower cognitive and motor function have been found to be related to psychotic experiences (PE) in middle childhood. These findings suggest a neurodevelopmental pathway to PE in childhood. This study examined if prospectively assessed neurodevelopment in infancy from birth to age 3 predicted PE at age 10.</div></div><div><h3>Methods</h3><div>We included data from the population-based prospective longitudinal cohort COPSAC₂₀₁₀ (n = 700). Parents reported on children milestones starting at 1 week old, language acquisition at 1 and 2 years of age, and children were evaluated on cognition at 2.5 years and general development at 3 years. At age 10, children were clinically assessed regarding PE. We used adjusted logistic regression models to assess the association between developmental within the first years of life and later PE.</div></div><div><h3>Results</h3><div>We evaluated 593 children at 10 years regarding PE, of which 77 (13 %) reported having experienced PE. We did not find significant associations between early life neurodevelopment and childhood PE. Analyses excluding children with neurodevelopmental diagnosis (i.e, ADHD, autism and tics) yielded similar results.</div></div><div><h3>Conclusions</h3><div>Delays in developmental milestones, language acquisition, and cognition during the first 3 years of life were not associated with PE in middle childhood. The findings do not support that childhood PE occurs associated with atypical early neurodevelopment. Given that we report results on one time point PE, clarification of associations with persistent PE are warranted.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 214-221"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143300454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating rare variant genetics and brain transcriptome data implicates novel schizophrenia putative risk genes","authors":"Shengtong Han ,&nbsp;Marieke Gilmartin ,&nbsp;Wenhui Sheng ,&nbsp;Victor X. Jin","doi":"10.1016/j.schres.2025.01.028","DOIUrl":"10.1016/j.schres.2025.01.028","url":null,"abstract":"<div><div>The etiology of schizophrenia is elusive, in part due to its polygenic nature. Genome-wide association studies (GWAS) have successfully identified hundreds of schizophrenia risk loci, that are pinpointed to over one hundred genes through fine mapping. Besides common variants with relatively small effect size from GWAS, rare variants or ultra rare variants also play a significant role in conferring the schizophrenia risk from SCHEMA (Schizophrenia Exome Sequencing Meta-Analysis) results. However, burden results from SCHEMA study indicate that more new risk genes remain hidden and to be discovered. To boost the power of identifying new risk genes, we integrated genetics from SCHEMA and transcriptome data from BrainSpan using a multi-omics integration tool, DAWN, through which we have identified 47 schizophrenia putative risk genes that include 19 new risk genes, in addition to nearly all SCHEMA risk genes with <em>FDR</em> &lt; 5 %. GO functional enrichment reveals that 47 SCZ putative risk genes are significantly enriched in cell to cell signaling, cell communications, transporter, in line with the hypothesis of two hit schizophrenia model. SynGO analysis suggests 47 schizophrenia putative risk genes are enriched in pre-synapse, synapse and post-synapse, supporting the well established link between synapses and schizophrenia.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 205-213"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143300458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auditory MMN is associated with the volume of thalamic higher order nuclei in individuals with psychotic disorders and healthy controls","authors":"Atle Bråthen Pentz ,&nbsp;Veronica Mäki-Marttunen ,&nbsp;Oda van Jole ,&nbsp;Stener Nerland ,&nbsp;Ingrid Melle ,&nbsp;Nils Eiel Steen ,&nbsp;Ingrid Agartz ,&nbsp;Lars T. Westlye ,&nbsp;Unn K. Haukvik ,&nbsp;Torgeir Moberget ,&nbsp;Erik G. Jönsson ,&nbsp;Ole A. Andreassen ,&nbsp;Torbjørn Elvsåshagen","doi":"10.1016/j.schres.2025.01.031","DOIUrl":"10.1016/j.schres.2025.01.031","url":null,"abstract":"<div><h3>Objective</h3><div>Predictive coding is a theoretical framework that integrates models of brain dysconnectivity and psychopathology in psychosis. Thalamocortical dysconnectivity as well as reduced thalamic volumes have been reported in psychotic disorders. However, the role of the thalamus in predictive coding is not clear. We examined the relationship between magnetic resonance imaging (MRI)- based thalamic nuclei volumes and mismatch negativity (MMN), a purported index of prediction error signaling known to be impaired in psychosis.</div></div><div><h3>Methods</h3><div>We obtained MRI and MMN using a roving paradigm from individuals with SCZ spectrum disorder (SSD, <em>n</em> = 60) or bipolar disorder (BD, <em>n</em> = 69) and HC (<em>n</em> = 252). We segmented volumes of 25 thalamic nuclei bilaterally and tested their associations with MMN amplitude using linear models while covarying for age, sex, diagnosis, and intracranial volumes (ICV).</div></div><div><h3>Results</h3><div>We did not find group differences in thalamic volumes that could account for differences in MMN, neither did we find significant volume × diagnosis interactions on MMN for any of the 25 nuclei examined. Across the whole sample, significant positive associations were found between MMN amplitude and the volumes of several higher-order thalamic nuclei, including the mediodorsal medial and lateral nuclei, anterior and medial pulvinar, nucleus reuniens, as well as the lateral geniculate nucleus.</div></div><div><h3>Conclusion</h3><div>The results demonstrate a positive association between MMN amplitude and volumes of thalamic association nuclei in patients with psychotic disorders and HC. These findings may suggest a modulatory role of the thalamus in prediction error signaling.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 222-233"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143353720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychopathology trajectories and relapse in first episode schizophrenia with assured long-acting injectable adherence over 24 months","authors":"Smit Retha,&nbsp;Luckhoff Hilmar,&nbsp;Phahladira Lebogang,&nbsp;Kilian Sanja,&nbsp;Emsley Robin,&nbsp;Asmal Laila","doi":"10.1016/j.schres.2025.01.007","DOIUrl":"10.1016/j.schres.2025.01.007","url":null,"abstract":"<div><h3>Background</h3><div>Relapse following a first episode of schizophrenia (FES) is common and often results in serious adverse psychosocial consequences. Treatment non-adherence is a key risk factor for relapse, but why relapse occurs despite antipsychotic treatment adherence remains unclear. This study examined the differences in FES psychopathology trajectories over 24-months with assured long-acting injectable antipsychotic (LAIA) treatment, to control for treatment adherence between those who relapsed and those who did not and what moderates these group differences.</div></div><div><h3>Methodology</h3><div>We collected clinical and socio-demographic data from 107 participants with FES treated with LAIA medication over a 24-month period. Relapse was defined using the modified Csernansky criteria. Substance use was assessed through participant and family interviews and urine toxicology. Linear mixed model repeated measures models were constructed to (1) compare psychopathology trajectories over 24 months between relapse versus non-relapse groups (2) to examine factors moderating differential trajectories between the groups.</div></div><div><h3>Results</h3><div>Positive symptom trajectories were significantly worse in the relapse compared to non-relapse group over 24 months (F(8, 649 = 3.29), <em>p</em> = 0.001). More severe childhood trauma (CT), in particular physical abuse (PA) (F(39, 298 = 1.78), <em>p</em> = 0.004), was associated with worse positive symptom trajectories over 24 months in those who experienced a relapse event.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that the examination of a history of CT and, in particular childhood PA measures for relapse in individuals with FES, is important.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 8-14"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synaptic dysfunctions in schizophrenia: Commonalities and divergences in Chinese and Indian populations","authors":"Aheli Chakraborty ,&nbsp;Nivedhitha Mukesh ,&nbsp;Anil Annamneedi","doi":"10.1016/j.schres.2025.01.012","DOIUrl":"10.1016/j.schres.2025.01.012","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 106-107"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using pupillometry to predict outcome in cognitive behavioral therapy for negative symptoms of schizophrenia","authors":"Christophe Delay ,&nbsp;Peter Link ,&nbsp;Jason Holden ,&nbsp;Eric Granholm","doi":"10.1016/j.schres.2025.01.014","DOIUrl":"10.1016/j.schres.2025.01.014","url":null,"abstract":"<div><h3>Background</h3><div>Clinical trials of cognitive-behavioral therapy (CBT) for negative symptoms of schizophrenia have provided mixed results, perhaps because some patients are more likely to benefit than others. Patients likely to benefit may be those with greater pre-treatment motivation. To better examine the effects of motivation on treatment outcome, more objective measures of motivation are needed. Pupillary responses provide an objective biomarker of cognitive effort and motivation, with greater dilation associated with greater effort and motivation.</div></div><div><h3>Aims</h3><div>The current study examined whether pre-treatment baseline pupil dilation predicted motivation and pleasure (MAP) negative symptom reduction in an open clinical trial of CBT for individuals with schizophrenia.</div></div><div><h3>Methods</h3><div>Pupil dilation was recorded during the digit-span task at low (3 digits), moderate (6 digits) and high (9 digits) loads in participants with schizophrenia or schizoaffective disorder (<em>N</em> = 31) with persistent negative symptoms prior to delivery of mobile-assisted CBT for negative symptoms (mCBTn).</div></div><div><h3>Results</h3><div>Greater pre-treatment pupil dilation during low, but not moderate or high, loads of the digit-span task significantly predicted greater reduction in MAP negative symptoms. However, while MAP negative symptoms improved throughout treatment, pupil dilation did not significantly change throughout treatment for any digit-span loads.</div></div><div><h3>Implications</h3><div>Pupil dilation may provide a much-needed prognostic biomarker of patients most likely to benefit from CBT for MAP symptoms, but did not change with change in MAP symptoms.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 135-142"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness is associated with different structural brain changes in schizophrenia spectrum disorders and major depression","authors":"Stefan Fritze ,&nbsp;Geva A. Brandt ,&nbsp;Sebastian Volkmer ,&nbsp;Jonas Daub ,&nbsp;Dilsa Cemre Akkoc Altinok ,&nbsp;Katharina M. Kubera ,&nbsp;Oksana Berhe ,&nbsp;Yuchen Lin ,&nbsp;Heike Tost ,&nbsp;Andreas Meyer-Lindenberg ,&nbsp;Dusan Hirjak","doi":"10.1016/j.schres.2025.01.001","DOIUrl":"10.1016/j.schres.2025.01.001","url":null,"abstract":"<div><h3>Background</h3><div>Loneliness, distress from having fewer social contacts than desired, has been recognized as a significant public health crisis. Although a substantial body of research has established connections between loneliness and various forms of psychopathology, our understanding of the neural underpinnings of loneliness in schizophrenia spectrum disorders (SSD) and major depressive disorder (MDD) remains limited.</div></div><div><h3>Methods</h3><div>In this study, structural magnetic resonance imaging (sMRI) data were collected from 57 SSD and 45 MDD patients as well as 41 healthy controls (HC). Loneliness was measured with the German version of the University of California, Los Angeles Loneliness Scale (UCLA-LS). We used FreeSurfer v7.2 for automated parcellation of cortical regions.</div></div><div><h3>Results</h3><div>SSD patients showed reduced cortical volume and thickness in fronto-parietal and temporal regions when compared to HC (<em>p</em> &lt; 0.05, Benjamini-Hochberg (BH) corr.). In SSD, volume of the right superior temporal gyrus was associated with UCLA-LS total score (<em>p</em> = 0.030; BH corr.). MDD patients showed reduced cortical volume and thickness in fronto-parietal regions (<em>p</em> &lt; 0.05, BH corr.). In MDD, cortical thickness of the right superior parietal cortex was associated with UCLA-LS total score (<em>p</em> = 0.038; BH corr.).</div></div><div><h3>Conclusion</h3><div>Our study suggests a different neural signature of loneliness in patients with SSD and MDD, comprising temporal and parietal regions responsible for social and attentive processing. Identifying neurobiological mechanisms underlying loneliness is critical for understanding its role in severe mental illnesses and identifying potential therapeutic targets.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 31-39"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}