Schizophrenia Research最新文献

{"title":"Association between decreased peripheral serum complement C3 levels and aberrant brain topology of morphological similarity networks in first-episode, drug-naïve schizophrenia","authors":"Kexin Zhang ,&nbsp;Xiaowei Xia ,&nbsp;Jiamin Dai ,&nbsp;Zixin Deng ,&nbsp;Shimao Kang ,&nbsp;Zilin Hong ,&nbsp;Zhinan Li ,&nbsp;Junyan Wu ,&nbsp;Cai Chen ,&nbsp;Yong Qiu ,&nbsp;Tong Liu ,&nbsp;Ming Chen ,&nbsp;Junxiao Ma ,&nbsp;Yanxi Liu ,&nbsp;Ziyi Zhang ,&nbsp;Qingni Shen ,&nbsp;Sichu Tao ,&nbsp;Yuqian Pan ,&nbsp;Fu Zhu ,&nbsp;Zhuang Kang ,&nbsp;Qinling Wei","doi":"10.1016/j.schres.2025.11.011","DOIUrl":"10.1016/j.schres.2025.11.011","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have highlighted the critical role of the complement system in schizophrenia. Dysregulated levels of complement C3 and C4 may affect structural brain networks in schizophrenia, yet their relationship remains unclear. This study aimed to explore the association between peripheral serum levels of complement and the topological properties of individualized morphological similarity networks (MSNs) in first-episode, drug-naïve schizophrenia (FES).</div></div><div><h3>Methods</h3><div>This study included 71 patients with FES and 92 healthy controls (HCs). Peripheral blood samples were collected to quantify C3 and C4 levels. Individualized MSNs were constructed for each participant separately based on cortical thickness (CT), gray matter volume (GMV), and surface area (SA), and then graph theoretical analysis was applied to compute topological properties. Group comparisons were performed on complement levels and MSN topological properties, followed by correlation analyses between altered measures.</div></div><div><h3>Results</h3><div>Compared to HCs, FES patients exhibited decreased C3 levels, with no significant difference in C4 levels. The FES group showed significantly lower clustering coefficient (C_p) than HCs. Nodal properties were altered in FES patients, characterized by decreased degree centrality and nodal efficiency in the left superior temporal sulcus and increased nodal efficiency in the left temporal pole for the CT-based networks. Moreover, within the FES group and the overall cohort, C3 levels were positively correlated with the C_p of MSNs.</div></div><div><h3>Conclusions</h3><div>The present study confirmed that decreased C3 levels are associated with the C_p of MSNs. Our findings suggest that the complement system may contribute to morphological network disruptions in FES.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"287 ","pages":"Pages 91-98"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis use and cardiometabolic risk in schizophrenia","authors":"Jai Paris ,&nbsp;Olivia Laurendi ,&nbsp;Victoria Arnet ,&nbsp;Cherrie Galletly","doi":"10.1016/j.schres.2025.11.013","DOIUrl":"10.1016/j.schres.2025.11.013","url":null,"abstract":"<div><h3>Purpose</h3><div>Metabolic syndrome (MetS) is common in schizophrenia and drives cardiovascular risk. While cannabis use and potency are increasing, the impact of cannabis on cardiometabolic health in schizophrenia remains unclear. This study assessed the association between objectively measured cannabis use and MetS prevalence in a large schizophrenia cohort.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional analysis of 988 participants with DSM-IV schizophrenia from the CATIE study. Cannabis use was measured via hair testing for tetrahydrocannabinol (THC), the gold standard for long-term use detection. MetS was defined per International Diabetes Federation criteria using physical and biochemical data. Multivariable logistic regression, adjusting for demographic, clinical, and lifestyle confounders, assessed the association between THC use and MetS.</div></div><div><h3>Results</h3><div>THC-positive participants (14.8 %) exhibited a significantly lower prevalence of MetS compared to non-users (42.5 % vs. 60.5 %, <em>p</em> &lt; 0.001). After adjusting for confounders including age, sex, ethnicity, smoking, and other substance use, cannabis use remained independently associated with reduced odds of MetS (adjusted OR 0.64, 95 %CI 0.44–0.93, <em>p</em> = 0.02). Among MetS components, cannabis users had significantly lower odds of elevated waist circumference after adjustment (adjusted OR 0.61, 95 %CI 0.41–0.91, <em>p</em> = 0.02). Cannabis use was also associated with lower weight, BMI and triglycerides and higher HDL in unadjusted analyses. No significant differences were found in blood pressure or fasting glucose.</div></div><div><h3>Conclusions</h3><div>In schizophrenia, cannabis use was associated with lower rates of both metabolic syndrome and central obesity. While these findings support emerging evidence of metabolic differences in cannabis users, the cross-sectional design precludes conclusions regarding causality. Longitudinal studies are needed to clarify long-term metabolic effects and guide targeted interventions.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"287 ","pages":"Pages 54-62"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fidelity to the first episode psychosis coordinated specialty care model in Massachusetts: Comparison to clinical outcomes and national programs","authors":"Nicole R. DeTore ,&nbsp;Kelsey Johnson ,&nbsp;Elizabeth S. Eberlin ,&nbsp;Iqra Imam ,&nbsp;Ananya Saluja ,&nbsp;Margaret Guyer ,&nbsp;Matcheri Keshavan ,&nbsp;Dost Öngür ,&nbsp;Kim T. Mueser ,&nbsp;Donald Addington","doi":"10.1016/j.schres.2025.11.009","DOIUrl":"10.1016/j.schres.2025.11.009","url":null,"abstract":"<div><div>Measuring fidelity to the components of the coordinated specialty care (CSC) model is a critical step in understanding the success of first episode of psychosis (FEP) programs. This study assessed the fidelity of nine Massachusetts CSC programs on a well-validated fidelity measure (the FEP Services Fidelity Scale: FEPS-FS 1.1) and a locally adapted measure (the Massachusetts Psychosis Fidelity Scale: MAPS). Associations between the two fidelity measures were examined, and correlations between fidelity and change in clinical outcomes on the Massachusetts Psychosis Network for Early Treatment assessment battery were explored within 684 clients served through these sites. Overall fidelity of the Massachusetts CSC program with programs in a national study of CSC were also compared on the FEPS-FS.</div><div>Several fidelity items (weekly team meetings, quick contact with referred clients, and procedural and structural aspects of programs) were related with clinical outcomes, including fewer emergency department visits within the first six months of treatment and client satisfaction at six months (<em>p</em>s &lt; 0.027). Overall CSC fidelity in Massachusetts was significantly higher than the national average (<em>p</em> &lt; .001) and fidelity did not differ between academically and non-academically affiliated sites.</div><div>The Massachusetts FEP programs had strong fidelity to the CSC model components, higher than national rates. Findings indicate that stronger fidelity may support relapse prevention, as higher fidelity in several key components was related to fewer emergency department visits. This study also highlights the utility of both a thoroughly researched and universal measure of CSC fidelity along with the importance of local adaptations to the measure.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"287 ","pages":"Pages 99-106"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145605580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The challenges in measuring symptoms of schizophrenia: An exploratory graph analysis of the Positive and Negative Syndrome Scale (PANSS)","authors":"Pedro Henrique Minotto Serafim ,&nbsp;Ary Gadelha ,&nbsp;Raffael Massuda ,&nbsp;Mario Louzã ,&nbsp;Clarissa Severino Gama ,&nbsp;Luisa de Castro Ostoja Roguski ,&nbsp;Pedro Henrique Pereira Alvim ,&nbsp;Leticia Sanguinetti Czepielewski","doi":"10.1016/j.schres.2025.11.010","DOIUrl":"10.1016/j.schres.2025.11.010","url":null,"abstract":"<div><h3>Background and hypothesis</h3><div>The Positive and Negative Syndrome Scale (PANSS) is a widely used instrument for assessing symptom severity in schizophrenia. Significant concerns remain regarding its structural validity, with no consensus on a definitive model. Although the five-factor model (positive, negative, cognitive, hostility, and affective) is the most widely accepted, studies have demonstrated instability in item distribution across factors and difficulty in achieving adequate fit indices. This exploratory study aims to evaluate the structural validity of the PANSS, addressing these previously identified issues and contributing to the theoretical debate on the limited evidence supporting a robust model fit.</div></div><div><h3>Study design</h3><div>Data from five independent Brazilian samples (<em>N</em> = 1262) were analyzed. We conducted Exploratory Graph Analysis (EGA) and bootstrap analysis to assess the stability of the PANSS structure. We estimated network loadings and conducted the Loadings Comparison Test (LCT) to evaluate differences between structural frameworks.</div></div><div><h3>Study results</h3><div>The analysis identified a five-dimensional model consistent with prior literature. However, this model proved unstable, appearing in only 66.3 % of bootstrap samples. Several items exhibited low stability across dimensions, and the LCT algorithm indicated that a network framework provided a better fit for the data.</div></div><div><h3>Conclusions</h3><div>In line with previous research, this study found that the PANSS exhibits an unstable structure and item distribution. Moreover, the scale presents several validity limitations, and the difficulty in achieving a consolidated model may reflect both methodological gaps in its original construction and the inherently multidimensional nature of certain symptoms.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"287 ","pages":"Pages 46-53"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145550373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the prognosis of adult Catatonia: A systematic review","authors":"Beatriz Rodriguez-Cabo ,&nbsp;Ana Catalan ,&nbsp;Claudia Aymerich ,&nbsp;Gonzalo Salazar de Pablo ,&nbsp;Miguel Angel Gonzalez-Torres","doi":"10.1016/j.schres.2025.11.006","DOIUrl":"10.1016/j.schres.2025.11.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Catatonia is a neuropsychiatric syndrome observed in psychiatric and physical conditions. Linked to neuroinflammation, schizophrenia spectrum disorders remain its principal diagnostic context. Short-term outcomes are favourable with prompt treatment. Long-term prognosis remains poorly understood. This systematic review aimed to evaluate long-term outcomes and mortality rates in individuals with catatonia.</div></div><div><h3>Methods</h3><div>We conducted a PRISMA–compliant systematic review (PROSPERO: CRD420251027945) searching PubMed, Web of Science, EMBASE, SCOPUS, PsycINFO, and non-peer-reviewed sources from database inception to July 12, 2025. We included studies of adults diagnosed with catatonia with a minimum 6-month follow-up. Catatonia diagnosis was based on criteria, scales, or clinical judgment. One-year mortality was estimated and compared to general population. Methodological quality was assessed using validated tools (NOS, JBI). Findings were synthesized narratively.</div></div><div><h3>Results</h3><div>Of 6431 records screened, 29 studies met inclusion criteria, encompassing 30,694 patients with catatonia and 11,830 controls. Mean follow-up was 8.1 years. Seventeen studies focused on schizophrenia. Quality of studies was heterogeneous; 58 % showed moderate concerns and 41 % were at high risk of bias. Post-1970s studies reported more episodes, readmissions, and chronicity in catatonic schizophrenia versus other schizophrenia subtypes. Poorer psychiatric outcomes were found when catatonia co-occurred with intellectual disability, depression, or physical illness. Catatonia associated with baseline suicidal ideation (&gt;35 % patients) and follow-up autoimmunity. In 75 % of post-1970s studies, one-year mortality in catatonia cohorts was lower than adjusted population rates.</div></div><div><h3>Conclusion</h3><div>Catatonia is a marker of poor psychiatric long-term prognosis, without clear link to higher mortality. Early use of effective treatments preventing suicide or psychosis relapses may be considered.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"287 ","pages":"Pages 21-36"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145550425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of avatar features and presence on treatment outcomes in virtual reality-assisted therapy for auditory hallucinations","authors":"Louise Birkedal Glenthøj ,&nbsp;Lise Sandvig Mariegaard ,&nbsp;Lisa Charlotte Smith ,&nbsp;Mads Juul Christensen ,&nbsp;Sara Nørgård Jensen ,&nbsp;Mar Rus-Calafell ,&nbsp;Neil Thomas ,&nbsp;Merete Nordentoft ,&nbsp;Ditte Lammers Vernal","doi":"10.1016/j.schres.2025.11.004","DOIUrl":"10.1016/j.schres.2025.11.004","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"287 ","pages":"Pages 1-2"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145499849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hippocampal-cortical system cerebral blood flow in schizophrenia: Primary disease versus antipsychotic medication effects","authors":"Alexa Ciarolla ,&nbsp;Anastasia M. Bobilev ,&nbsp;Filip Dybowski ,&nbsp;Yan Fang ,&nbsp;Carolyn Sacco ,&nbsp;Jayme M. Palka ,&nbsp;Sina Aslan ,&nbsp;Peiying Liu ,&nbsp;Hanzhang Lu ,&nbsp;Carol A. Tamminga ,&nbsp;Elena I. Ivleva","doi":"10.1016/j.schres.2025.11.003","DOIUrl":"10.1016/j.schres.2025.11.003","url":null,"abstract":"<div><div>Most of the brain-based biomarker research in schizophrenia (SZ) results from chronic medicated samples. Disambiguating contributions of “primary” disease vs. psychotropic medication effects to the neurobiology of SZ remains challenging. In this study, using 3Tesla pseudo-continuous Arterial Spin Labeling (pCASL), we examined regional cerebral blood flow (CBF) in hippocampus and its cortical projection network in SZ probands [n = 41, including antipsychotic-free (SZ-OFF, n = 14) and treated with antipsychotic(s) (SZ-ON, n = 27)], their first-degree relatives [n = 28, including relatives with lifetime psychosis-spectrum disorders (REL-P, n = 14) and without (REL-NP, n = 14)], and healthy controls (HC, n = 16) [n = 85 total].</div><div>SZ-OFF demonstrated elevated CBF in the left middle cingulate, ventromedial and dorsolateral prefrontal cortex (PFC), compared to SZ-ON (Hedges' <em>g</em> = 0.65–0.91). No difference in hippocampal CBF emerged in SZ-OFF vs. SZ-ON, while SZ-OFF vs. HC showed reduced CBF in the left anterior hippocampus (<em>g</em> = 1.09). Among relatives, REL-P had elevated CBF in the right ventrolateral PFC, compared to REL-NP (<em>g</em> = 0.73) – resembling the “hyperfrontality” effect in SZ-OFF. Conversely, REL-NP vs. HC showed reduced CBF throughout the right PFC (<em>g</em> = 0.52–0.79).</div><div>Our findings demonstrate unique regional CBF-based activity signatures potentially capturing <em>primary disease effects</em> (SZ-OFF: elevated CBF in PFC but reduced CBF in the anterior hippocampus) vs. <em>antipsychotic effects</em> (SZ-ON: “normalization” of CBF). The observed PFC “hyperactivity” (evidenced by elevated CBF in both SZ-OFF and REL-P) may constitute a regionally-specific “psychosis maker”. Future research targeted at granular aspects of hippocampal-PFC pathology in medicated and unmedicated samples may inform more precise, novel interventions in SZ.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"287 ","pages":"Pages 3-15"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the relative efficacy of xanomeline/trospium from placebo-controlled trials","authors":"Ninoslav Majkic ,&nbsp;David Taylor","doi":"10.1016/j.schres.2025.11.012","DOIUrl":"10.1016/j.schres.2025.11.012","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"287 ","pages":"Pages 71-72"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145574195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fracture risk in the offspring of individuals with schizophrenia: A cohort study of 71,698 children","authors":"Shiau-Chi Wang ,&nbsp;Ju-Wei Hsu ,&nbsp;Shih-Jen Tsai ,&nbsp;Ya-Mei Bai ,&nbsp;Tung-Ping Su ,&nbsp;Tzeng-Ji Chen ,&nbsp;Wei-Sheng Huang ,&nbsp;Mu-Hong Chen","doi":"10.1016/j.schres.2025.11.015","DOIUrl":"10.1016/j.schres.2025.11.015","url":null,"abstract":"<div><h3>Background</h3><div>Parental schizophrenia is associated with various adverse developmental outcomes in offspring, including neurodevelopmental impairments and elevated physical injury risks. However, limited evidence is available regarding the association between parental schizophrenia and fracture risk in offspring, particularly during adolescence—a developmental stage characterized by increased susceptibility to fractures. In this study, we investigated whether parental schizophrenia influences the risk of fractures in offspring.</div></div><div><h3>Methods</h3><div>Relevant data were collected from Taiwan's National Health Insurance Research Database. This retrospective cohort study included 6518 offspring of individuals with schizophrenia and 65,180 age- and sex-matched children whose parents had no severe mental disorders. The cohort was followed from 1996 or birth until the end of 2011. Incident fractures during this period were identified. Cox proportional-hazards models, adjusted for demographic characteristics and psychiatric comorbidities in offspring, were used to estimate hazard ratios (HRs) and corresponding 95 % confidence intervals (CIs) for fracture risk.</div></div><div><h3>Results</h3><div>Compared with the offspring of individuals without schizophrenia, those of individuals with this condition had significantly increased risks of any fractures (HR: 1.10; 95 % CI: 1.03–1.18), skull fractures (HR: 1.38; 95 % CI: 1.13–1.68), lower limb fractures (HR: 1.15; 95 % CI: 1.03–1.28), and severe fractures requiring hospitalization (HR: 1.20; 95 % CI: 1.08–1.34). The increased fracture risk was particularly pronounced during adolescence (HR: 1.14; 95 % CI: 1.03–1.26).</div></div><div><h3>Conclusion</h3><div>The offspring of individuals with schizophrenia have an increased risk of fractures, particularly during adolescence. Early screening and targeted preventive strategies—including interventions for attention regulation and motor skill difficulties—are needed to reduce fracture risk in this vulnerable population.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"287 ","pages":"Pages 107-112"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Highlights","authors":"","doi":"10.1016/S0920-9964(25)00438-4","DOIUrl":"10.1016/S0920-9964(25)00438-4","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"287 ","pages":"Pages A1-A2"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145839807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}