Ambient coarse particulate matter pollution and hospital admissions for schizophrenia.

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research Pub Date : 2025-01-24 DOI:10.1016/j.schres.2025.01.004

Yating Ma, Lijun Bai, Yunxing Jiang, Jinxi Wang, Chen Wei, Yinxiang Li, Yumei Tian, Shaowei Wu

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引用次数: 0

Abstract

Objective: To investigate the association between ambient coarse particulate matter (PM_2.5_-₁₀) pollution and risk of acute schizophrenia episodes.

Methods: A time-stratified case-crossover study with a two-stage analytical approach was conducted to investigate the association between ambient PM_2.5_-₁₀ pollution and schizophrenia admissions (an indicator for acute schizophrenia episodes) across 259 Chinese cities of prefecture-level or above during 2013-2017. A conditional logistic regression model was constructed to estimate city-specific changes in hospital admissions for schizophrenia associated with per interquartile range (IQR) increase in ambient PM_2.5_-₁₀, and the overall associations were obtained by pooling the city-specific associations using the random-effects model.

Results: A total of 817,296 schizophrenia admissions were included in the analysis. Per IQR increase (28.43 μg/m³) in PM_2.5_-₁₀ at lag01 was associated with an increase of 1.66 % (95 % CI: 0.68 %, 2.65 %) in schizophrenia admissions. Compared to concentrations <30 μg/m³, PM_2.5_-₁₀ concentrations of 30-49 μg/m³ and ≥50 μg/m³ were associated with increases of 2.25 % (95 % CI: 0.73 %%, 3.79 %) and 4.03 % (95 % CI: 1.92 %, 6.18 %) in schizophrenia admissions, respectively. City-level urbanization has the potential to attenuate the association between ambient PM_2.5_-₁₀ and schizophrenia admissions (P = 0.0002).

Conclusions: Our study provides novel evidence for the acute adverse effects of ambient PM_2.5_-₁₀ on schizophrenia and calls for special attention on the control of high PM_2.5_-₁₀ pollution in disease prevention.

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来源期刊

Schizophrenia Research 医学-精神病学

CiteScore

7.50

自引率

8.90%

发文量

429

审稿时长

10.2 weeks

期刊介绍： As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership! Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue. The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.