Schizophrenia Research最新文献

{"title":"Sex differences in the relationship between the vascular endothelial growth factor and cognition in drug-naïve schizophrenia","authors":"Xiaoxiao Sun ,&nbsp;Ying Xu ,&nbsp;Yanqing Wu ,&nbsp;Meijuan Li ,&nbsp;Yuying Qiu ,&nbsp;Qiao Su ,&nbsp;Jiayue Wang ,&nbsp;Jie Li ,&nbsp;Fuqiang Mao","doi":"10.1016/j.schres.2025.02.002","DOIUrl":"10.1016/j.schres.2025.02.002","url":null,"abstract":"<div><h3>Background</h3><div>This study investigates the sex-specific relationship between plasma Vascular Endothelial Growth Factor (VEGF) levels and cognitive performance in drug-naïve schizophrenia (DNS) patients, focusing on longitudinal changes.</div></div><div><h3>Methods</h3><div>A total of 175 DNS patients and 80 healthy controls (HCs) completed the MATRICS Consensus Cognitive Battery (MCCB). VEGF levels were measured via ELISA, and DNS patients were assessed using the Positive and Negative Syndrome Scale (PANSS). Partial correlations and multiple linear regressions were used to evaluate the relationships between VEGF, cognition, and symptom severity, adjusting for demographic and clinical factors.</div></div><div><h3>Results</h3><div>Female DNS patients showed greater cognitive impairments than female HCs (all <em>P</em> &lt; 0.05), while male DNS patients had specific deficits in Attention/Vigilance (<em>P</em> = 0.027) and Working Memory (<em>P</em> = 0.002). Among females, baseline VEGF levels were inversely correlated with psychotic symptoms, including PANSS Positive symptom scores (<em>r</em> = −0.281) and PANSS total scores (<em>r</em> = −0.224). Additionally, baseline VEGF levels were positively associated with cognitive performance, including Processing Speed (<em>r</em> = 0.302), Neurocognition (<em>r</em> = 0.193), and the MCCB total score (<em>r</em> = 0.201). In males, baseline VEGF levels showed a trend toward predicting less severe negative symptoms at the 8-week (<em>β</em> = −0.42, <em>P</em> = 0.060), though not statistically significant.</div></div><div><h3>Conclusion</h3><div>VEGF may protect cognition in female DNS patients through neuroprotective or anti-inflammatory mechanisms. Higher VEGF levels in females were linked to better cognition and milder symptoms over time. These findings suggest VEGF as a potential sex-specific biomarker for schizophrenia, warranting further investigation.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 9-17"},"PeriodicalIF":3.6,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socially relevant affective learning in psychosis: Relations to deficits in motivation and pleasure and cognitive ability","authors":"Ryan D. Orth ,&nbsp;Imani L. Todd ,&nbsp;Kristen R. Dwyer ,&nbsp;Melanie E. Bennett ,&nbsp;Jack J. Blanchard","doi":"10.1016/j.schres.2025.02.003","DOIUrl":"10.1016/j.schres.2025.02.003","url":null,"abstract":"<div><div>Negative symptoms are common in psychotic disorders and significantly contribute to functional impairment. Deficits in reward processing and memory have been implicated as important factors which contribute to negative symptoms, leading to speculation that deficits in learning and memory of socially relevant information may be particularly important. Previous work has also found poorer learning of positive social behavior associations in psychotic disorders, but limitations have prevented an examination of symptom correlates of this diminished learning. In the present study, we used an updated social affective learning task to examine whether diminished accuracy in learning the affective value of others was related to motivation and pleasure negative symptoms as well as cognitive deficits. Results indicated that participants were able to use both positive and negative behavioral information to generate accurate socially evaluative perceptions. Results also demonstrated that reduced accuracy of learning from positive behavioral information was related to greater motivation and pleasure symptoms and cognitive deficits, including working memory, while reduced accuracy of learning from negative behavioral information was only related to cognitive deficits across multiple domains. When controlling for cognition, motivation and pleasure symptoms were no longer related to positive affective learning, but working memory remained related to learning when controlling for motivation and pleasure symptoms. These findings underscore the role of diminished positive affective learning in negative symptoms and suggest that poorer learning of the positive value of others may be one pathway through which cognitive deficits lead to reduced reward anticipation, defeatist performance beliefs, and negative symptoms.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 1-8"},"PeriodicalIF":3.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sub-clinical systemic inflammation as a determinant of admission duration in psychosis","authors":"Graham Blackman ,&nbsp;James DeLaney ,&nbsp;James H. MacCabe ,&nbsp;Golam Khandaker ,&nbsp;Philip McGuire","doi":"10.1016/j.schres.2024.12.010","DOIUrl":"10.1016/j.schres.2024.12.010","url":null,"abstract":"<div><h3>Background</h3><div>The immune system may play an important role in the aetiology of psychotic disorders and there is increasing interest in the relationship between immune markers and clinical outcomes in psychosis. The present study investigated whether subclinical systemic inflammation was associated with length of stay in individuals with psychosis admitted to a psychiatric hospital. We tested the hypothesis that a higher level of subclinical systemic inflammation, as measured by the neutrophil-to-lymphocyte ratio (NLR) would be associated with a longer period in hospital.</div></div><div><h3>Method</h3><div>Retrospective cohort study based on electronic health records. We included patients with a psychosis spectrum disorder (ICD10: F20-F29) who had a routine blood test upon being admitted to a psychiatric hospital within the South London and Maudsley NHS Foundation Mental Health Trust, London, UK between 2013 and 2019. Multiple linear regression was used to determine the association between the NLR at the time of admission and the duration of the corresponding hospital stay, adjusting for covariables.</div></div><div><h3>Results</h3><div>Data from 1683 individuals with psychosis were analyzed. The median admission duration was 31 days (interquartile range = 48 days). Higher neutrophil-to-lymphocyte ratio (NLR) was significantly associated with longer admission (<span><math><mi>B</mi></math></span> = 0.07, <em>p</em> <em>&lt;</em> 0.003) after adjusting for covariates.</div></div><div><h3>Conclusion</h3><div>An association between a NLR and a longer admission, whilst controlling for relevant covariables, was observed highlighting the potential utility of inflammatory markers as prognostic marker in clinical settings.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 17-23"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional intelligence as a predictor of functional outcomes in psychotic disorders","authors":"Jennifer M. Blank ,&nbsp;Roman Kotov ,&nbsp;Katherine G. Jonas ,&nbsp;Wenxuan Lian ,&nbsp;Elizabeth A. Martin","doi":"10.1016/j.schres.2025.01.005","DOIUrl":"10.1016/j.schres.2025.01.005","url":null,"abstract":"<div><div>Psychotic disorders are associated with significant impairment in psychosocial functioning, yet mechanisms associated with this impairment remain poorly understood. Emotional intelligence, a component of social cognition, is associated with psychosocial functioning in this population. However, prior work has used relatively small samples, reported inconsistent relations between functioning domains and emotional intelligence, and inconsistently considered negative symptoms. To address these limitations, we examined the predictive ability of emotional intelligence on functional outcomes using a five-year longitudinal design. We used a large sample of individuals with and without psychotic disorder diagnoses (N = 324), a performance-based measure of emotional intelligence, and three measures of functioning (i.e., social performance, assessor-rated social and occupational functioning, self-rated functioning in independent living). Results revealed individuals diagnosed with a psychotic disorder have lower emotional intelligence than those without a history of psychosis. Emotional intelligence was associated with social performance and social and occupational functioning in both those with and without a history of psychosis. In those diagnosed with a psychotic disorder, emotional intelligence and negative symptoms better predict social performance (<span><math><mi>β</mi></math></span>_Emotional = 0.36, R²_delta = 0.09) and social and occupational functioning (<span><math><mi>β</mi></math></span>_Emotional = 0.21, R² = 0.03), but not self-rated functioning in independent living (<span><math><mi>β</mi></math></span>_Emotional = −0.08, R²_delta = 0.00), as compared to negative symptoms alone. Overall, findings support the use of emotional intelligence as a longitudinal predictor of social and occupational outcomes above and beyond negative symptoms alone. This work highlights potential, specific intervention targets for individuals with psychotic disorders.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 97-105"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic interactions among schizotypal traits, affective and prodromal symptoms, social functioning in a large sample of college students: A cross-lagged panel network analysis","authors":"Shou-nuo Chen ,&nbsp;Guo-hui Zhu ,&nbsp;Juan Yang ,&nbsp;Wen-ting Hu ,&nbsp;Xue Meng ,&nbsp;Li-ying Zhang ,&nbsp;Yi Wang ,&nbsp;Yan-yu Wang","doi":"10.1016/j.schres.2025.01.016","DOIUrl":"10.1016/j.schres.2025.01.016","url":null,"abstract":"<div><h3>Objective</h3><div>Previous studies suggested that schizotypal traits are closely related with affective symptoms and social dysfunction in general population. However, the dynamic interactions among these variables across time remain unclear. This study aimed to investigate this issue using cross-sectional and longitudinal network analysis.</div></div><div><h3>Methods</h3><div>A total of 9136 college students completed self-report scales measuring schizotypal traits, anxiety, depression, prodromal risk, and social functioning at timepoint 1 (T1) and six months later. Classical contemporaneous network analysis was used to estimate the associations among all variables at T1, and the cross-lagged panel network analysis was performed to estimate the predictive effects at follow-up. In addition, prodromal high-risk and low-risk subgroups at T1 were identified using Prodromal Questionnaire (PQ-16) to investigate differences on network constructs and edge weights using Network Comparison Tests (NCT).</div></div><div><h3>Results</h3><div>Contemporaneous network showed that negative dimension of schizotypal traits, anxiety, and depression interacted and were all negatively correlated with social functioning. Of all the nodes in the network, interpersonal features of schizotypal traits was the most centralized. The results of cross-lagged network analysis further verified the predictive effect of personality traits and emotions on social function. In addition, NCT revealed significant difference between prodromal high-risk and low-risk subgroups in network structure and strength of edges connecting schizotypal traits, affective symptoms with prodromal risk, but not in global strength.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that schizotypal traits, affective symptoms, and prodromal risk relate to social functioning, both independently and through their dynamic interactions.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 108-116"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA-regulated suppression of some overexpressed genes in schizophrenia and their evolutionary significance","authors":"Deepika Sharma ,&nbsp;Srinjay Kumar Bharadaj ,&nbsp;Stella Bharadaj ,&nbsp;Supriyo Chakraborty","doi":"10.1016/j.schres.2025.01.022","DOIUrl":"10.1016/j.schres.2025.01.022","url":null,"abstract":"<div><div>Impaired formation of the brain or nervous system is the root cause of neurodevelopmental disorders which appear in pregnancy or soon after birth. One such neurodevelopmental disorder is Schizophrenia. Among the most serious forms of psychosis, Schizophrenia (SCZ) affects 1 % of the general population. MiRNA targeting sites and codon usage of nine overexpressed genes in Schizophrenia were investigated in this study. The neutrality plot demonstrated the importance of natural selection over mutational pressure in the evolution of these genes. The analysis of COSM revealed that the miRNA target regions of the genes were encoded by non-optimal codons, resulting in low translational efficiency, whereas the GC content revealed that the miRNA-mRNA binding was strong. From this study it was concluded that each overexpressed gene was targeted by several human miRNAs for putative suppression. These identified miRNAs could have therapeutic potential in Schizophrenia therapy.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 143-156"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the behavioural inhibition and activation system in the association between attachment style and positive or negative symptoms in patients with psychosis and unaffected siblings","authors":"Justine de With ,&nbsp;Marieke van der Pluijm ,&nbsp;Lieuwe de Haan ,&nbsp;Frederike Schirmbeck ,&nbsp;Genetic Risk and Outcome of Psychosis (GROUP) investigators","doi":"10.1016/j.schres.2025.01.020","DOIUrl":"10.1016/j.schres.2025.01.020","url":null,"abstract":"<div><h3>Background</h3><div>The association between attachment style and psychotic symptomatology is well established. However, little is known about the mechanisms underlying this relationship. In the present study, we aimed to investigate whether the sensitivity of the behavioural inhibition and activation system mediates the association between attachment style and positive or negative symptoms, in patients with psychotic disorders and unaffected siblings.</div></div><div><h3>Methods</h3><div>In a subsample of the Genetic Risk and Outcome of Psychosis (GROUP) study (87 patients and 94 siblings), attachment style was assessed using the Psychotic Attachment Measure, behavioural inhibition or activation with the Behavioral Inhibition System (BIS) and Behavioral Activation System (BAS) Scale and positive and negative symptomatology with the Community Assessment of Psychic Experiences. Linear regression models and mediation models were used, while correcting for age and gender and adjusting for multiple testing.</div></div><div><h3>Results</h3><div>We found that anxious and avoidant attachment were associated with negative symptoms across both groups. Additionally, in siblings, anxious and avoidant attachment were associated with positive symptoms. In the patient group, BIS sensitivity mediated the association between anxious attachment and negative symptoms. In the sibling group, BIS sensitivity mediated the association between avoidant attachment and both positive and negative symptoms, and between anxious attachment and positive symptoms.</div></div><div><h3>Conclusions</h3><div>Findings indicate that BIS sensitivity, but not BAS sensitivity, is a possible mediating mechanism contributing to the association between insecure attachment and psychotic symptoms. Longitudinal studies are required to confirm the associations between attachment style, BIS and BAS sensitivity, and psychotic symptoms, and explore causality.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 127-134"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A letter to the editor: Abnormalities in auditory lateralization during spatial mismatch negativity tasks in male patients with schizophrenia","authors":"Xiong Jiao ,&nbsp;Qiang Hu ,&nbsp;Wenli Zhu ,&nbsp;Wei Ren ,&nbsp;Yingying Bu ,&nbsp;Wenwen Miao ,&nbsp;Chuanfu Song ,&nbsp;Junfeng Sun ,&nbsp;Chunbo Li ,&nbsp;Jijun Wang","doi":"10.1016/j.schres.2025.01.030","DOIUrl":"10.1016/j.schres.2025.01.030","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 234-236"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Highlights","authors":"","doi":"10.1016/S0920-9964(25)00052-0","DOIUrl":"10.1016/S0920-9964(25)00052-0","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Page A1"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143465143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obsessive-compulsive symptoms and personal recovery in patients with schizophrenia spectrum disorders: A cross-sectional study","authors":"A. Jelsma ,&nbsp;F. Schirmbeck ,&nbsp;M. van der Pluijm ,&nbsp;C. Simons ,&nbsp;A. Vellinga ,&nbsp;M. de Koning ,&nbsp;L. de Haan","doi":"10.1016/j.schres.2025.01.008","DOIUrl":"10.1016/j.schres.2025.01.008","url":null,"abstract":"<div><h3>Background</h3><div>Obsessive-compulsive symptoms (OCS) frequently co-occur in patients with Schizophrenia Spectrum Disorders (SSD). Patients with SSD and OCS experience increased clinical and social challenges, including diminished quality of life and subjective well-being. However, it is unknown whether co-morbid OCS are associated with personal recovery.</div></div><div><h3>Aim</h3><div>To investigate whether the presence and severity of OCS in patients with SSD is associated with lower self-reported personal recovery.</div></div><div><h3>Methods</h3><div>A cross-sectional design was employed, examining 527 patients with SSD. Group comparisons between patients with and without OCS for self-reported personal recovery (assessed with the Recovery Assessment Scale (RAS-24)) were conducted using analysis of covariance, adjusting for positive, negative and general symptoms. Multiple regression analyses were performed in 133 patients with co-occurring OCS to assess the additional explained variance in personal recovery by OCS severity after adjusting for the same covariates in the first block of the model.</div></div><div><h3>Results</h3><div>Group comparisons demonstrated that the presence of co-morbid OCS was associated with lower scores in personal recovery. Multiple hierarchical regression analyses showed that OCS severity was significantly associated with personal recovery by explaining an additional 3.0 % of variance in personal recovery.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that co-occurring OCS in patients with SSD are relevant for personal recovery and that treatment should also address OCS.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"276 ","pages":"Pages 24-30"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}