drug-naïve精神分裂症患者血管内皮生长因子与认知关系的性别差异

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research Pub Date : 2025-02-16 DOI:10.1016/j.schres.2025.02.002

Xiaoxiao Sun , Ying Xu , Yanqing Wu , Meijuan Li , Yuying Qiu , Qiao Su , Jiayue Wang , Jie Li , Fuqiang Mao

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引用次数: 0

摘要

本研究探讨drug-naïve精神分裂症（DNS）患者血浆血管内皮生长因子（VEGF）水平与认知表现之间的性别特异性关系，重点关注纵向变化。方法175例DNS患者和80例健康对照（hc）完成了matrix共识认知测试（MCCB）。采用ELISA法检测VEGF水平，采用阳性和阴性综合征量表（PANSS）对DNS患者进行评估。采用偏相关和多元线性回归来评估VEGF、认知和症状严重程度之间的关系，并对人口统计学和临床因素进行调整。结果女性DNS患者比女性hc患者表现出更大的认知障碍(P <；男性DNS患者在注意/警觉性（P = 0.027）和工作记忆（P = 0.002）方面存在特异性缺陷。在女性中，基线VEGF水平与精神病症状呈负相关，包括PANSS阳性症状评分（r = - 0.281）和PANSS总分（r = - 0.224）。此外，基线VEGF水平与认知表现呈正相关，包括处理速度（r = 0.302）、神经认知（r = 0.193）和MCCB总分（r = 0.201）。在男性中，基线VEGF水平在8周时显示出预测较轻的阴性症状的趋势（β = - 0.42, P = 0.060），尽管没有统计学意义。结论vegf可能通过神经保护或抗炎机制保护女性DNS患者的认知功能。随着时间的推移，女性体内较高的VEGF水平与更好的认知能力和较轻的症状有关。这些发现表明VEGF可能是精神分裂症的性别特异性生物标志物，值得进一步研究。

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Sex differences in the relationship between the vascular endothelial growth factor and cognition in drug-naïve schizophrenia

Background

This study investigates the sex-specific relationship between plasma Vascular Endothelial Growth Factor (VEGF) levels and cognitive performance in drug-naïve schizophrenia (DNS) patients, focusing on longitudinal changes.

Methods

A total of 175 DNS patients and 80 healthy controls (HCs) completed the MATRICS Consensus Cognitive Battery (MCCB). VEGF levels were measured via ELISA, and DNS patients were assessed using the Positive and Negative Syndrome Scale (PANSS). Partial correlations and multiple linear regressions were used to evaluate the relationships between VEGF, cognition, and symptom severity, adjusting for demographic and clinical factors.

Results

Female DNS patients showed greater cognitive impairments than female HCs (all P < 0.05), while male DNS patients had specific deficits in Attention/Vigilance (P = 0.027) and Working Memory (P = 0.002). Among females, baseline VEGF levels were inversely correlated with psychotic symptoms, including PANSS Positive symptom scores (r = −0.281) and PANSS total scores (r = −0.224). Additionally, baseline VEGF levels were positively associated with cognitive performance, including Processing Speed (r = 0.302), Neurocognition (r = 0.193), and the MCCB total score (r = 0.201). In males, baseline VEGF levels showed a trend toward predicting less severe negative symptoms at the 8-week (β = −0.42, P = 0.060), though not statistically significant.

Conclusion

VEGF may protect cognition in female DNS patients through neuroprotective or anti-inflammatory mechanisms. Higher VEGF levels in females were linked to better cognition and milder symptoms over time. These findings suggest VEGF as a potential sex-specific biomarker for schizophrenia, warranting further investigation.

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来源期刊

Schizophrenia Research 医学-精神病学

CiteScore

7.50

自引率

8.90%

发文量

429

审稿时长

10.2 weeks

期刊介绍： As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership! Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue. The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.