Schizophrenia Research最新文献

{"title":"Issue Highlights","authors":"","doi":"10.1016/j.annepidem.2024.07.052","DOIUrl":"10.1016/j.annepidem.2024.07.052","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"279 ","pages":"Page A1"},"PeriodicalIF":3.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142231984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive health experiences of women and non-binary people with early psychosis: a qualitative study","authors":"Amanda Toufeili ,&nbsp;Simone N. Vigod ,&nbsp;Juveria Zaheer ,&nbsp;Zakia Hussain ,&nbsp;Julia France ,&nbsp;Ananka Rodriguez ,&nbsp;Shakked Lubotzky-Gete ,&nbsp;Suze Berkhout ,&nbsp;Robert Dmytryshyn ,&nbsp;Sheila Dunn ,&nbsp;Renu Gupta ,&nbsp;Fardous Hosseiny ,&nbsp;Frank Sirotich ,&nbsp;Sophie Soklaridis ,&nbsp;Aristotle N. Voineskos ,&nbsp;Lucy C. Barker","doi":"10.1016/j.schres.2025.04.016","DOIUrl":"10.1016/j.schres.2025.04.016","url":null,"abstract":"<div><h3>Background and hypothesis</h3><div>Psychosis typically emerges in young adulthood and can impact reproductive health, including risk for suboptimal fertility and unplanned pregnancies. This study aimed to explore the reproductive health experiences of young women and non-binary people with psychosis.</div></div><div><h3>Study design</h3><div>In this qualitative study, young women and non-binary service users with experience of early psychosis in Toronto, Canada participated in semi-structured interviews about their reproductive health experiences (sexual health experiences analyzed separately). Clinicians providing healthcare for this population also participated in interviews/focus groups. Thematic analysis was used to describe core themes among service users, then understand how clinician perspectives related to these.</div></div><div><h3>Study results</h3><div>Interviews with service users (<em>n</em> = 19, aged 18–31; cisgender women <em>n</em> = 15, transgender women <em>n</em> = 2, non-binary individuals n = 2) yielded two core themes: (1) Complex reproductive health needs exist irrespective of psychosis, and (2) Psychosis does specifically impact reproductive health priorities and plans. These were discussed across three clinical content areas: contraception, menstruation, and future pregnancy/family planning. A final theme emerged from clinicians (<em>n</em> = 36): (3) Clinicians grapple with clinical complexity, and sometimes have different priorities than their patients (e.g., menstruation was a priority for service users only).</div></div><div><h3>Conclusions</h3><div>This study offers insights into the reproductive health experiences of women and non-binary individuals with early psychosis, including complexity that exists irrespective of psychosis, and additional psychosis-related complexity. The study also explored clinicians' perspectives, and identified areas of discordance between service user and clinician perspectives (e.g., related to menstruation). Findings can help shape interventions to improve this population's reproductive health.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Pages 95-102"},"PeriodicalIF":3.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential gene expression study in whole blood identifies candidate genes for psychosis in African American individuals","authors":"E.E.M. Knowles ,&nbsp;J.M. Peralta ,&nbsp;A.L. Rodrigue ,&nbsp;S.R. Mathias ,&nbsp;J. Mollon ,&nbsp;A.C. Leandro ,&nbsp;J.E. Curran ,&nbsp;J. Blangero ,&nbsp;D.C. Glahn","doi":"10.1016/j.schres.2025.04.018","DOIUrl":"10.1016/j.schres.2025.04.018","url":null,"abstract":"<div><div>Genome-wide association has identified regions of the genome that mediate risk for psychosis. It is possible that variants in these regions confer risk by altering gene expression. This work has predominantly been conducted in individuals of European descent and has focused narrowly on schizophrenia rather than psychosis as a syndrome. In the present study we investigated alterations in gene expression in African American individuals with a range of psychotic diagnoses to increase understanding of the etiology in an underserved population.</div><div>We performed RNA-seq in whole bloody to survey the transcriptome in 126 patients with a psychosis-spectrum disorder and 217 healthy controls and applied differential gene expression analyses across the genome while controlling for age, sex, population stratification and batch. We found 18 differentially expressed genes (DEGs), some of the locations of the corresponding genes overlap with previously implicated regions for psychosis, but many of which were novel associations. Enrichment analysis of nominally significant genes (<em>p</em> &lt; 0.05) revealed overrepresentation of biological processes relating to platelet, immune and cellular function, and sensory perception. Weighted gene co-expression network analysis, applied to identify modules of co-expressed genes associated with psychosis, revealed 10 modules, one of which was significantly associated with psychosis. This module was significantly enriched for DEGs, and for platelet function. These results support the potential role of immune function in the etiology of psychosis, identify novel candidate gene expression phenotypes that correspond to both established and new genomic regions, in individuals of African American ancestry.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Pages 85-94"},"PeriodicalIF":3.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CBT for psychosis in Parkinson's disease: A framework for how and why","authors":"Jennifer A. Foley ,&nbsp;Vaughan Bell","doi":"10.1016/j.schres.2025.04.023","DOIUrl":"10.1016/j.schres.2025.04.023","url":null,"abstract":"<div><div>Psychosis is a serious comorbidity to Parkinson's disease associated with high levels of distress and disability but access to effective treatments remain limited, leading to high rates of emergency hospitalization. Here, we propose a new framework for how cognitive behavioural therapy (CBT) may be used to treat Parkinson's disease psychosis. We note specific adaptions, including aims that focus on reducing distress and disability and extending quality of life; tailored psychoeducation; assessment and formulation that additionally includes disease course, medication effects and side-effects, and Parkinson's specific social factors; addressing anxiety and depression alongside cognitive appraisals for the types of psychotic symptoms more common in Parkinson's disease; appropriate reality testing sensitive to disease progression; and trigger monitoring and management for hallucinations and delusions that carefully distinguishes this from avoidant coping. We review preliminary case study-level evidence for the successful use of CBT for Parkinson's disease psychosis and suggest a road map for its formal evaluation before integration into evidence-based healthcare.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Pages 69-75"},"PeriodicalIF":3.6,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aripiprazole or metformin for hyperprolactinemia in women with schizophrenia: A 6-month, real-world chart review study","authors":"Jie Yang ,&nbsp;Xuequan Zhu ,&nbsp;Weiwei Wang ,&nbsp;Hu Wang ,&nbsp;Haochu Gong ,&nbsp;Yunjing Zhang ,&nbsp;Christoph U. Correll ,&nbsp;Le Xiao ,&nbsp;Gang Wang","doi":"10.1016/j.schres.2025.04.011","DOIUrl":"10.1016/j.schres.2025.04.011","url":null,"abstract":"<div><h3>Objectives</h3><div>Antipsychotic-induced hyperprolactinemia is a relevant clinical issue. In this study, we aimed to evaluate the comparative efficacy of adjunctive aripiprazole and metformin in treating antipsychotic-induced hyperprolactinemia among female patients with schizophrenia.</div></div><div><h3>Methods</h3><div>A chart review of females diagnosed with schizophrenia and hospitalized from 2010 to 2020, all with antipsychotic-induced hyperprolactinemia and elevated serum prolactin levels. Data included antipsychotic types, baseline and post-intervention prolactin levels. Remission was defined as prolactin levels below 25 ng/dL in females. Cox regression and instrumental variables were used to assess remission hazard ratios at 30, 60, and 180 days.</div></div><div><h3>Results</h3><div>Among 652 female inpatients (mean age = 38.8 ± 12.7 years; 53.2 % on haloperidol, 17.8 % on risperidone) with hyperprolactinemia (mean baseline prolactin: 69.9 ± 47.8 ng/dL), 366 (56.1 %) received add-on aripiprazole (mean baseline prolactin: 76.5 ± 51.3 ng/dL) and 286 (43.9 %) received metformin (mean baseline prolactin: 61.5 ± 41.6 ng/dL). Aripiprazole was associated with decreased prolactin levels on the 30th day with a remission rate of 73.6 % compared to a 15.0 % remission rate in the metformin group. The effect was significantly greater in the low-dose group (aripiprazole ≤5 mg). Throughout the 180-day follow-up period, the final remission rate was substantially higher in the aripiprazole group than in the metformin group (77.6 % vs 23.1 %). Aripiprazole outperformed metformin in treating hyperprolactinemia induced primarily by haloperidol (remission rate 79.9 %), quetiapine (72.7 %), olanzapine (68.8 %) and risperidone (65.2 %) (all <em>p</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>This real-world study suggests that adjunctive aripiprazole therapy effectively reduces prolactin levels in females with antipsychotic-induced hyperprolactinemia. Maximum efficacy is achieved at no &gt;5 mg/day and within 30 days.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Pages 76-84"},"PeriodicalIF":3.6,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cultural variables influence performance on the MATRICS Consensus Cognitive Battery among people at clinical high risk for psychosis","authors":"Ryan M. Guest ,&nbsp;Katrina Aberizk ,&nbsp;Jean Addington ,&nbsp;Carrie E. Bearden ,&nbsp;Kristin S. Cadenhead ,&nbsp;Tyrone D. Cannon ,&nbsp;Barbara A. Cornblatt ,&nbsp;Matcheri S. Keshavan ,&nbsp;Daniel H. Mathalon ,&nbsp;Diana O. Perkins ,&nbsp;William S. Stone ,&nbsp;Scott W. Woods ,&nbsp;Elaine F. Walker","doi":"10.1016/j.schres.2025.04.019","DOIUrl":"10.1016/j.schres.2025.04.019","url":null,"abstract":"<div><h3>Background &amp; hypothesis</h3><div>Prior studies suggest that cognitive batteries normed in the U.S. may not be suitable for populations that differ in English proficiency and/or cultural background. Here, we investigated how cultural variables (i.e., length of residence, native English speaker) influence cognitive performance within a U.S. and Canadian sample of people at clinical high risk for psychosis (CHR-P) and healthy control (HC) participants.</div></div><div><h3>Study design</h3><div>The sample consisted of 925 adolescents and adults (664 CHR-P, 261 HC) from the second cohort of the North American Prodromal Longitudinal Study, including 73 (7.9 %) foreign-born participants and 94 (10.2 %) who reported a language other than English as their first language. Multigroup structural equation modeling was used to estimate effects of cultural variables on MATRICS Consensus Cognitive Battery (MCCB) subtests, separately in each diagnostic group.</div></div><div><h3>Study results</h3><div>A structural model that generated unique estimates for all parameters in group models was selected. For CHR-P, longer length of residence in U.S./Canada related to better performance on Animal Naming (β = 0.09, <em>p</em> = .01), whereas being a native English speaker related to better performance on Letter-Number Span (β = 0.14, <em>p =</em> .001) and Hopkins Verbal Learning Test – Revised (β = 0.10, <em>p =</em> .03). In contrast, no such relationships were observed among HCs.</div></div><div><h3>Conclusions</h3><div>Findings extend our understanding of how cultural variables may influence presentation of psychosis-risk syndromes and suggest that being a non-native English speaker or having recently immigrated may hinder performance on certain verbal neuropsychological measures.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Pages 60-68"},"PeriodicalIF":3.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to dynamic network analysis of schizophrenia spectrum traits, affective symptoms, and social functioning—Opportunities and challenges","authors":"Shou-nuo Chen,&nbsp;Yan-yu Wang","doi":"10.1016/j.schres.2025.04.013","DOIUrl":"10.1016/j.schres.2025.04.013","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Page 59"},"PeriodicalIF":3.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampus subfield volume reductions in treatment-resistant schizophrenia","authors":"Alexandra Fortier ,&nbsp;Andràs Tikàsz ,&nbsp;Maria Athanassiou ,&nbsp;Inès Zouaoui ,&nbsp;Nancy Légaré ,&nbsp;Emmanuel Stip ,&nbsp;Olivier Lipp ,&nbsp;Alexandre Dumais ,&nbsp;Stéphane Potvin","doi":"10.1016/j.schres.2025.04.006","DOIUrl":"10.1016/j.schres.2025.04.006","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding: Dynamic network analysis of schizophrenia spectrum traits, affective symptoms, and social functioning—Opportunities and challenges","authors":"Chao Lu ,&nbsp;Da Huang ,&nbsp;Jiaxin Su ,&nbsp;Zhaoxia Huang","doi":"10.1016/j.schres.2025.04.008","DOIUrl":"10.1016/j.schres.2025.04.008","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Pages 48-49"},"PeriodicalIF":3.6,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DLG2 rs11607886 polymorphism associated with schizophrenia and precuneus functional changes","authors":"HanYu Zhu ,&nbsp;Zhaoyang Wu ,&nbsp;Junxiao Wang ,&nbsp;Enhui Zhang ,&nbsp;Sen Zhang ,&nbsp;Yongfeng Yang ,&nbsp;Wenqiang Li ,&nbsp;Han Shi ,&nbsp;Ge Yang ,&nbsp;Luxian Lv ,&nbsp;Yan Zhang","doi":"10.1016/j.schres.2025.04.004","DOIUrl":"10.1016/j.schres.2025.04.004","url":null,"abstract":"<div><h3>Background and hypothesis</h3><div>Schizophrenia (SZ) is a severe mental disorder with high heritability. <em>DLG2</em> encodes the postsynaptic scaffolding protein DLG2 (PSD93, Postsynaptic Density Protein 93), and its variants were associated with an increased risk of SZ. However, the role of <em>DLG2</em> locus variation in SZ remains elusive. This study aims to investigate the association between <em>DLG2</em> gene polymorphisms and SZ susceptibility and the relationship between <em>DLG2</em> and altered brain function and clinical symptoms in SZ patients.</div></div><div><h3>Study design</h3><div>Single nucleotide polymorphisms (SNPs) rs11607886 and rs7479949 were genotyped in 350 SZ patients and 407 healthy controls (HCs). 47 SZ patients and 79 HCs were genotyped into two groups: the risk A allele carrier group and the GG-pure group. Functional magnetic resonance imaging (fMRI) indices were further analyzed. Subsequently, data from different brain regions were correlated with clinical symptom assessment.</div></div><div><h3>Study results</h3><div><em>DLG2</em> rs11607886 was significantly associated with SZ. Significant main effects were found in the ALFF and ReHo, especially for the left precuneus gyrus (PCu). A significant interaction between genotype and diagnosis had a significant effect on FC, which was increased between the left PCu and the right middle temporal gyrus in carriers of the A allele with SZ (<em>r</em> = −0.336, <em>P</em>_un-corrected = 0.042) and negatively correlated with spatial breadth scores (<em>r</em> = 0.444, <em>P</em>_{FDR-corrected} = 0.002).</div></div><div><h3>Conclusions</h3><div>The rs11607886 polymorphism in <em>DLG2</em> may influence the pathogenesis of SZ and have potential effects on cognitive function. The present study emphasizes <em>DLG2</em> as a candidate gene for SZ and suggests an important role for PCu in SZ.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"280 ","pages":"Pages 50-58"},"PeriodicalIF":3.6,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}