Changes in degree centrality and its associated genes: A longitudinal study of patients with schizophrenia undergoing pharmacological treatment

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research Pub Date : 2025-03-01 DOI:10.1016/j.schres.2025.03.009

Linna Zhang , Chunguo Zhang , Haohao Yan , Yiding Han , Caixia Xu , Jiaquan Liang , Runyi Li , Ningning Chen , Wenting Liang , Wei Huang , Guojun Xie , Wenbin Guo

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引用次数: 0

Abstract

Background

The role of degree centrality (DC) in schizophrenia (SCZ), its trajectory following pharmacological treatment, and its potential as a prognostic biomarker and genetic mechanism remain unclear.

Methods

We recruited 51 healthy controls (HC) and 56 patients with SCZ. Additionally, the SCZ patients underwent three months of antipsychotic medication treatment. We collected resting-state functional magnetic resonance imaging data, clinical variables, and conducted analyses using support vector machines, support vector regression, and gene expression correlation analysis.

Results

Our study revealed that SCZ patients had generally reduced DC values in the cerebral cortex compared to HC at baseline, with increased DC values observed in the left occipital gyrus. After three months of treatment, SCZ patients exhibited a significant decrease in DC values in the left fusiform gyrus and an increase in the left inferior parietal gyrus. Variations in DC values in SCZ patients were associated with multiple genes, primarily enriched in molecular functions.

Conclusion

Changes in DC values in the right inferior occipital/fusiform gyrus and right calcarine/middle occipital gyrus may serve as neuroimaging markers to differentiate between HC and SCZ patients. Additionally, DC values in the left middle/postcentral gyrus could be used to predict treatment outcomes. Transcriptome-neuroimaging spatial correlation analysis provides valuable insights into the neurobiological mechanisms underlying SCZ pathology.

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度中心性的变化及其相关基因：对接受药物治疗的精神分裂症患者的纵向研究

在精神分裂症（SCZ）中，度中心性（DC）的作用、其在药物治疗后的发展轨迹、其作为预后生物标志物和遗传机制的潜力仍不清楚。方法招募51例健康对照（HC）和56例SCZ患者。此外，SCZ患者接受了三个月的抗精神病药物治疗。我们收集静息状态功能磁共振成像数据、临床变量，并使用支持向量机、支持向量回归和基因表达相关性分析进行分析。结果我们的研究显示，与HC相比，SCZ患者在基线时大脑皮层DC值普遍降低，左侧枕回DC值升高。治疗3个月后，SCZ患者左侧梭状回DC值明显下降，左侧顶叶下回DC值明显升高。SCZ患者DC值的变化与多个基因有关，主要富集于分子功能。结论右侧枕下回/梭状回和右侧枕骨回/枕中回DC值的变化可作为区分HC和SCZ患者的神经影像学指标。此外，左中央后回的DC值可用于预测治疗结果。转录组-神经成像空间相关性分析为了解SCZ病理背后的神经生物学机制提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Schizophrenia Research 医学-精神病学

CiteScore

7.50

自引率

8.90%

发文量

429

审稿时长

10.2 weeks

期刊介绍： As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership! Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue. The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.