Relations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis

IF 3.6 2区 医学 Q1 PSYCHIATRY
Katrina Aberizk , Esra Sefik , Qingyue Yuan , Hengyi Cao , Jean M. Addington , Carrie E. Bearden , Kristin S. Cadenhead , Tyrone D. Cannon , Barbara A. Cornblatt , Matcheri Keshavan , Daniel H. Mathalon , Diana O. Perkins , William S. Stone , Scott W. Woods , Elaine F. Walker , Benson S. Ku
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引用次数: 0

Abstract

Temporoparietal brain areas comprise a candidate set of regions for interrogating the brain functional correlates of socioenvironmental factors in people at clinical high-risk for psychosis (CHR-P). Temporal lobe abnormalities have been shown to be common among people with schizophrenia spectrum conditions. Further, temporoparietal brain regions are implicated in tasks relevant to psychosocial outcomes, including coherent autobiographical memory recall and multimodal integration. This report examined relations of hippocampal-temporoparietal functional connectivity with neighborhood-level social fragmentation, a composite of area-level characteristics that measures social cohesion, among youth at CHR-P and healthy comparisons in the second wave of the North American Prodrome Longitudinal Study (n = 146, age = 19.9 ± 3.9, 47 % female). This study also examined whether those relations were moderated by individual-level social engagement in desirable activities. Significant positive relations of neighborhood-level social fragmentation and hippocampal functional connectivity with the superior temporal pole were observed among participants at CHR-P. Moderation analyses demonstrated that those relations were significant only at low and mean levels of individual-level social engagement in participants at CHR-P. Findings contribute to the literature indicating that adverse environmental factors are associated with deviant patterns of brain connectivity. This exploratory research also contributes to future theorizing about neurobiological mechanisms underlying therapeutic interventions involving social engagement that have demonstrated improved functional outcomes for people with psychotic disorders.
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来源期刊
Schizophrenia Research
Schizophrenia Research 医学-精神病学
CiteScore
7.50
自引率
8.90%
发文量
429
审稿时长
10.2 weeks
期刊介绍: As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership! Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue. The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.
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