Revue neurologique最新文献

{"title":"Autosomal recessive cerebellar ataxia: What have we learnt in the last 30 years?","authors":"C Tranchant","doi":"10.1016/j.neurol.2026.09.002","DOIUrl":"https://doi.org/10.1016/j.neurol.2026.09.002","url":null,"abstract":"<p><p>Knowledge in the field of autosomal-recessive cerebellar ataxia (ARCA) has considerably improved since the discovery of the Friedreich ataxia gene in 1996. Numerous entities have been described in which cerebellar ataxia may be the first sign or appear during the course of the disease. Even though new sequencing tools have made genetic diagnosis much easier, management of patients with ARCA requires careful phenotypic analysis in order to propose the most effective genetic studies, rapidly track down treatable ARCA, and discuss the pathogenicity of new WGS-identified missense variants.</p>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in PLS: Natural history studies, extra-motor deficits, novel instruments, neuroimaging, epidemiology and genetics.","authors":"A Toomey, J Kleinerova, M Tahedl, N Mandal, J Lope, P Bede","doi":"10.1016/j.neurol.2026.07.008","DOIUrl":"https://doi.org/10.1016/j.neurol.2026.07.008","url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family history and offspring risk in juvenile myoclonic epilepsy.","authors":"P Gélisse, P Genton, A Crespel","doi":"10.1016/j.neurol.2026.09.001","DOIUrl":"https://doi.org/10.1016/j.neurol.2026.09.001","url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and regional disparities in triptan dispensing in France between 2014 and 2025: A nationwide open-data study.","authors":"S Redon, V Arcani, A Donnet","doi":"10.1016/j.neurol.2026.08.003","DOIUrl":"https://doi.org/10.1016/j.neurol.2026.08.003","url":null,"abstract":"<p><strong>Background: </strong>In France, triptans are currently the only reimbursed migraine-specific acute treatments. Previous French reimbursement-based studies have examined triptan use, healthcare burden, and prescribing preferences, but an integrated nationwide assessment of long-term dispensing trends has been lacking. We therefore aimed to assess nationwide trends in triptan dispensing, prescribing patterns, demographic characteristics, and regional disparities in France.</p><p><strong>Methods: </strong>We conducted a nationwide repeated cross-sectional study using OpenMedic, an open-access database derived from the French National Health Data System (SNDS). All reimbursed triptan dispensations identified using the ATC code N02CC were analyzed between 2014 and 2025. Annual dispensing indicators, demographic characteristics, prescriber categories, regional dispensing rates, and molecule-specific dispensing patterns were evaluated.</p><p><strong>Results: </strong>The annual number of dispensed triptan packages increased by 17.5% between 2014 and 2025 (4.1 to 4.8 million), whereas the number of treated patients remained relatively stable (969,927 to 949,639). Dispensing rates increased from 62.4 to 70.7 packages per 1000 inhabitants, while the mean number of dispensed packages per treated patient increased from 4.25 to 5.11. Reimbursement expenditures markedly decreased from €138.1 million to €66.7 million. Dispensing rates increased most markedly among individuals aged≥60 years. General practitioners remained the main prescribers, although the contribution of neurologists and hospital physicians progressively increased. Persistent regional disparities were observed across French regions.</p><p><strong>Conclusion: </strong>Triptan dispensing in France increased substantially between 2014 and 2025 despite stable numbers of treated patients. This evolution was mainly characterized by increasing dispensing intensity among treated patients, greater involvement of specialist prescribers, and persistent regional disparities.</p>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Neuroimaging confirms selective cerebral involvement in primary lateral sclerosis and predilection to brain regions with high metabolic activity\" [Rev Neurol. 182 (2026): 514-27].","authors":"Fnu Sarah, Fnu Sobh","doi":"10.1016/j.neurol.2026.08.002","DOIUrl":"https://doi.org/10.1016/j.neurol.2026.08.002","url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cranial nerve III palsy with contralateral peripheral upper-limb involvement in Lyme neuroborreliosis.","authors":"T Sinha, H Khuram, N S Streicher","doi":"10.1016/j.neurol.2026.08.001","DOIUrl":"https://doi.org/10.1016/j.neurol.2026.08.001","url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Access to hospital-based rehabilitation for people with multiple sclerosis in France: A nationwide study (2017-2023).","authors":"M Mainguy, C Massot, P Gallien, V Reynaud, E Leray, C Donzé","doi":"10.1016/j.neurol.2026.07.007","DOIUrl":"https://doi.org/10.1016/j.neurol.2026.07.007","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) is frequently associated with progressive motor and functional impairment that requires multidisciplinary rehabilitation. In France, coordinated inpatient and outpatient rehabilitation is delivered at hospital-based facilities. However, national population-based data on the access to these services by people with MS (PwMS) are scarce.</p><p><strong>Objective: </strong>To determine the access to hospital-based rehabilitation by PwMS in France from 2017 to 2023, and identify individual, clinical and contextual factors that influence its utilization.</p><p><strong>Methods: </strong>This nationwide retrospective study (2017-2023) used data from the French National Health Data System. The association of patient characteristics, disease severity, and territorial healthcare indicators with rehabilitation access was assessed with multilevel analyses. Regional disparities and patient flows were described using spatial analyses.</p><p><strong>Results: </strong>Among the 130,015 PwMS (72.1% women, mean age [SD]: 54.0 [14.5] years), 12,325 (9.5%) had at least one hospital-based rehabilitation stay in 2023 (22,160 stays: 32.2% inpatient and 67.8% outpatient stays). Fewer women had hospital-based rehabilitation (8.6% vs. 11.8% of men). Physiotherapy use was higher among patients with than without a hospital-based rehabilitation stay (76.5% vs. 35.9%). Rehabilitation access was strongly associated with disease severity, use of walking aids, and treatment with fampridine. Access was also strongly influenced by service availability, particularly the physical and rehabilitation medicine (PRM) doctors' density, resulting in marked geographical disparities and substantial inter-departmental patient flows. Outpatient care was mostly delivered locally, whereas inpatient care was concentrated in a limited number of centers, generating substantial inter-departmental patient flows.</p><p><strong>Conclusions: </strong>Access to hospital-based rehabilitation for PwMS in France remains limited and uneven, despite the expected substantial needs. Utilization is primarily driven by disease severity and availability of specialized professionals, particularly PRM, and also by territorial and sex-related disparities. These findings highlight a persistent gap between recommendations and real-world practice, underscoring the need to strengthen rehabilitation pathways, improve service availability, and integrate rehabilitation earlier in the MS care pathway.</p>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of levodopa-carbidopa intestinal gel infusion on objective measures of daytime sleepiness and nocturnal sleep in Parkinson's disease.","authors":"M Bucy, N Carpentier, G Clement, S Richard, S Frismand-Kryloff, E Ruppert","doi":"10.1016/j.neurol.2026.07.002","DOIUrl":"https://doi.org/10.1016/j.neurol.2026.07.002","url":null,"abstract":"<p><strong>Background: </strong>Excessive daytime sleepiness and sleep disturbances are common in Parkinson's disease (PD), considerably affecting the quality of life of patients and caregivers. Antiparkinsonian medications further complicate sleep-wake management. Advanced PD with motor fluctuations often requires continuous dopaminergic stimulation via apomorphine subcutaneous infusion or levodopa/carbidopa intestinal gel infusion (LCIGI). Evidence on LCIGI's effects on sleep and sleepiness remains limited, relying mainly on subjective bias-prone measures.</p><p><strong>Objective: </strong>This pilot study used overnight in-laboratory polysomnography (PSG) and the multiple sleep latency test (MSLT), the gold standards for objective measurements, to evaluate effects of LCIGI initiation on sleep and sleepiness.</p><p><strong>Methods: </strong>In this prospective, monocentric observational study, 34 patients with motor fluctuations underwent PSG and MSLT before (M0) and three months after (M3) LCIGI initiation. Clinical characteristics included body mass index (BMI), L-Dopa equivalent daily dose (LEDD), and Epworth Sleepiness Scale (ESS) scores to examine correlations between subjective questionnaire-based and objective MSLT-based measures.</p><p><strong>Results: </strong>Twenty-three patients completed both assessments. MSLT values remained stable (M0: 12.5 [10.9; 15.8] min; M3: 15.3 [12.2; 16.6] min; P=0.401) as did PSG parameters. As expected, BMI decreased, LEDD increased, dopamine agonist use declined, and clozapine/quetiapine use increased. ESS scores did not correlate with MSLT results at baseline or follow-up.</p><p><strong>Conclusions: </strong>LCIGI had no significant impact on objectively measured daytime sleepiness (MSLT) or PSG sleep parameters.</p>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Passive digital monitoring via mobile apps and wearables in multiple sclerosis: A systematic review.","authors":"Paolo De Blasiis, Annunziata Attena, Allegra Fullin, Ciro Ivan De Girolamo, Antonio Carotenuto, Elisabetta Signoriello, Vincenzo Brescia Morra, Giacomo Lus, Francesco Isgrò, Nicola Moccaldi, Pasquale Arpaia","doi":"10.1016/j.neurol.2026.07.006","DOIUrl":"https://doi.org/10.1016/j.neurol.2026.07.006","url":null,"abstract":"<p><p>Effective management of multiple sclerosis requires precise monitoring to detect disease progression, yet conventional episodic assessments often fail to capture subtle functional decline. This systematic review aimed to synthesize current evidence on passive digital phenotyping via smartphones and wearable sensors as a tool for continuous and ecological evaluation. Following PRISMA guidelines, fourteen studies meeting strict eligibility criteria were included. These investigations analyzed raw data collected unobtrusively from smartphone touchscreens, inertial sensors, and photoplethysmography. The signals were processed to extract digital features, including keystroke dynamics, gait metrics, physiological markers, and behavioral patterns, to test their associations with standard clinical scales. The results demonstrated robust, significant correlations between these objective digital biomarkers and established clinical scores across motor, cognitive, and symptomatic domains. Specifically, processed typing kinematics and gait parameters significantly aligned with upper limb dexterity and walking ability respectively, while specific keystroke latency metrics proved sensitive to cognitive processing speed. Furthermore, multimodal physiological and behavioral markers successfully tracked complex symptoms such as fatigue, depression, and sleep quality. Overall, the findings highlighted that the integration of these multimodal biomarkers into clinical practice offers a scalable, non-invasive solution for personalized management. This approach could facilitate the early detection of \"silent\" symptoms and optimize therapeutic strategies, effectively bridging the critical gap between sporadic clinical visits and real-world functioning in multiple sclerosis.</p>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complement inhibition as rescue therapy in life-threatening refractory chronic inflammatory demyelinating polyneuropathy.","authors":"Audrey Cambier, Simon Jean-Marie, Karine Viala, Charline Benoit, Nicolas Weiss, Clémence Marois","doi":"10.1016/j.neurol.2026.07.005","DOIUrl":"https://doi.org/10.1016/j.neurol.2026.07.005","url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}