Evaluation of choroidal thickness changes in patients with migraine using optical coherence tomography

IF 2.3 4区医学 Q2 CLINICAL NEUROLOGY

Revue neurologique Pub Date : 2025-07-24 DOI:10.1016/j.neurol.2025.06.004

M. Rekik , Y. Walha , K.S. Moalla , S. Kammoun , C. Mhiri , M. Dammak , A. Trigui

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引用次数: 0

Abstract

Introduction

Optical coherence tomography (OCT) has enabled the study of ocular impairments associated with certain neurological pathologies, such as migraine. This common condition represents a risk factor for ocular ischemic complications. We investigated changes in choroidal thickness (CT) in migraine patients with and without aura (MWA and MWoA respectively) compared to healthy controls using OCT and identified factors influencing the occurrence of these anomalies in migraine.

Methods

This was a cross-sectional case-control study including migraine patients and control subjects. All patients and controls underwent a complete ophthalmological examination and CT measurements using a spectral domain-OCT device (DRI OCT Triton; Topcon Corp, Japan). The duration of migraine, the frequency and duration of migraine attacks, the migraine disability assessment (MIDAS) and migraine severity scale (MIGSEV) questionnaire scores were recorded.

Results

One hundred and twenty eyes from 60 patients (60 eyes in the MWoA group and 60 eyes in the MWA group) were included. The control group included 30 age- and gender-matched healthy participants (60 eyes). OCT revealed that CT was significantly reduced in MWoA and MWA groups compared with the control group and in the MWA group compared to MWoA group. The duration of migraine and attacks as well as the disease severity were correlated with CT. Multiregression analysis showed that disease severity was the main determinant of CT.

Conclusion

Our study highlights the significant impact of both types of migraine on choroidal structure. OCT proves to be promising in understanding migraine pathophysiology and potentially serves as a valuable biomarker for diagnosis and monitoring.

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光学相干断层成像评价偏头痛患者脉络膜厚度变化。

光学相干断层扫描（OCT）使得与某些神经系统疾病（如偏头痛）相关的眼损伤的研究成为可能。这种常见情况是眼缺血并发症的危险因素。我们利用OCT研究了有和无先兆偏头痛患者（分别为MWA和MWoA）与健康对照组相比脉络膜厚度（CT）的变化，并确定了影响偏头痛中这些异常发生的因素。方法：这是一项横断面病例对照研究，包括偏头痛患者和对照组。所有患者和对照组均接受了完整的眼科检查和CT测量，使用光谱域OCT设备(DRI OCT Triton；Topcon公司，日本)。记录偏头痛持续时间、偏头痛发作频率和持续时间、偏头痛残疾评估（MIDAS）和偏头痛严重程度量表（MIGSEV）问卷得分。结果：纳入60例患者120只眼（MWoA组60只眼，MWA组60只眼）。对照组包括30名年龄和性别匹配的健康参与者（60只眼睛）。OCT显示MWoA组和MWA组与对照组相比CT明显降低，MWA组与MWoA组相比CT明显降低。偏头痛持续时间、发作时间及病情严重程度与CT相关。多元回归分析显示疾病严重程度是CT的主要决定因素。结论：我们的研究强调了两种类型的偏头痛对脉络膜结构的显著影响。OCT被证明在了解偏头痛病理生理方面是有希望的，并且可能作为诊断和监测的有价值的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revue neurologique 医学-临床神经学

CiteScore

4.80

自引率

0.00%

发文量

598

审稿时长

55 days

期刊介绍： The first issue of the Revue Neurologique, featuring an original article by Jean-Martin Charcot, was published on February 28th, 1893. Six years later, the French Society of Neurology (SFN) adopted this journal as its official publication in the year of its foundation, 1899. The Revue Neurologique was published throughout the 20th century without interruption and is indexed in all international databases (including Current Contents, Pubmed, Scopus). Ten annual issues provide original peer-reviewed clinical and research articles, and review articles giving up-to-date insights in all areas of neurology. The Revue Neurologique also publishes guidelines and recommendations. The Revue Neurologique publishes original articles, brief reports, general reviews, editorials, and letters to the editor as well as correspondence concerning articles previously published in the journal in the correspondence column.