Revista Brasileira de Psiquiatria最新文献_第8页

Depressive symptoms and self-rated health among Brazilian older adults: baseline data from the ELSI-Brazil study. 巴西老年人的抑郁症状和自评健康:来自Elsi巴西研究的基线数据

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2023-11-23 DOI: 10.47626/1516-4446-2023-3331

Natalia T Ito, Déborah Oliveira, Fabricio M S Rodrigues, Erico Castro-Costa, Maria F Lima-Costa, Cleusa P Ferri

{"title":"Depressive symptoms and self-rated health among Brazilian older adults: baseline data from the ELSI-Brazil study.","authors":"Natalia T Ito, Déborah Oliveira, Fabricio M S Rodrigues, Erico Castro-Costa, Maria F Lima-Costa, Cleusa P Ferri","doi":"10.47626/1516-4446-2023-3331","DOIUrl":"10.47626/1516-4446-2023-3331","url":null,"abstract":"Objective: To investigate whether having a higher number of depressive symptoms is associated with negative self-rated health (SRH) even in the absence of illness.Methods: This is a secondary analysis of baseline data from the Brazilian Longitudinal Study of Aging (ELSI-Brazil), conducted in 2015-2016, using a national sample of 9,412 people aged 50 or over. SRH was dichotomized into poor or very poor and very good or excellent, good, or average. Depressive symptoms were assessed through the eight-item Center for Epidemiologic Studies Depression Scale (CES-D8). Sociodemographic variables, information about unhealthy behaviors, and the number of chronic conditions were also analyzed.Results: Having depressive symptoms was strongly associated with poor or very poor SRH both in the unadjusted and adjusted analyses. The magnitude of the association was reduced when the number of chronic illnesses was included in the multivariate analysis, along with the other sociodemographic variables and unhealthy behaviors (OR 1.35, 95%CI 1.31-1.39).Conclusion: Having depressive symptoms may contribute towards having a poorer perception of health, even in the absence of health conditions. SRH is a multidimensional construct that can accurately reflect a person's state of general mental health.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the COVID-19 pandemic on the symptomatology and routine of medicated patients with obsessive-compulsive disorder. COVID-19 大流行对强迫症患者症状和日常用药的影响。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-02-07 DOI: 10.47626/1516-4446-2023-3333

Natália B Almeida, Maria Paula Maziero, Tais Tanamatis, Danel Lucas da Conceição Costa, Roseli G Shavitt, Marcelo Q Hoexter, Marcelo C Batistuzzo

{"title":"Impact of the COVID-19 pandemic on the symptomatology and routine of medicated patients with obsessive-compulsive disorder.","authors":"Natália B Almeida, Maria Paula Maziero, Tais Tanamatis, Danel Lucas da Conceição Costa, Roseli G Shavitt, Marcelo Q Hoexter, Marcelo C Batistuzzo","doi":"10.47626/1516-4446-2023-3333","DOIUrl":"10.47626/1516-4446-2023-3333","url":null,"abstract":"Objectives: To study the impact of coronavirus disease 2019 on the routine of patients with obsessive-compulsive disorder (OCD) and changes in symptoms and suicidal-related behavior, mainly in those with cleaning symptoms.Methods: In this cross-sectional study, 58 patients completed an online self-report questionnaire that included the Obsessive-Compulsive Inventory-Revised, Coronavirus Stress and Traumatic Events Scale, Coronavirus Health Impact Survey, Beck Anxiety and Beck Depression inventories, and Suicide-Related Behaviors Questionnaire. Comparisons were made with another pre-pandemic sample (n=524) regarding the last three measures.Results: During the pandemic, the patients spent more days inside their homes (χ² = 33.39, p = 0.007), changed their alcohol consumption patterns (χ² = 87.6, p < 0.001), and increased social media usage (χ² = 68.83, p < 0.001). Participants with cleaning symptoms did not significantly differ from the others in relation to stress, anxiety/depressive symptoms, or suicidal-related behaviors. Finally, our sample did not differ from an equivalent OCD sample assessed before the pandemic in terms of anxiety and depressive symptom severity or suicidal-related behaviors.Conclusion: Overall, patients with OCD showed no lifestyle changes associated with higher stress levels during the pandemic. Patients with and without cleaning symptoms and patients before and during the pandemic presented similar results.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attention-deficit/hyperactivity disorder in Mozambique: an epidemiological investigation in a primary school sample. 莫桑比克的多动症：小学抽样流行病学调查。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-01-19 DOI: 10.47626/1516-4446-2023-3343

Helena Mutede Cutótua Daniel, Igor Duarte, Arthur Caye, Antonio Suleman, Wilza Fumo, Luis Augusto Rohde

{"title":"Attention-deficit/hyperactivity disorder in Mozambique: an epidemiological investigation in a primary school sample.","authors":"Helena Mutede Cutótua Daniel, Igor Duarte, Arthur Caye, Antonio Suleman, Wilza Fumo, Luis Augusto Rohde","doi":"10.47626/1516-4446-2023-3343","DOIUrl":"10.47626/1516-4446-2023-3343","url":null,"abstract":"Objective: To evaluate the prevalence of attention-deficit/hyperactivity disorder (ADHD), comorbidity rates with disruptive behavior disorders and main negative outcomes in primary school students in Nampula, Mozambique.Methods: We selected a random sample of 748 students for ADHD screening from a population of around 43,000 primary school students. The Swanson, Nolan, and Pelham Rating Scale version IV was applied to both parents and teachers. All students who screened positive (n=76) and a propensity score-matched random subset of students who screened negative (n=76) were assessed by a child psychiatrist.Results: The prevalence of ADHD was estimated at 13.4% (95%CI 11.5-19.2), and 30.6% of those with ADHD presented comorbid disruptive behavior disorders. Students with ADHD (n=36) had significantly higher rates of both substance use (alcohol, marijuana) (p < 0.001), and school failures than controls (n=96; p < 0.001). Comorbidity between ADHD and disruptive behavior disorders increased the chance of substance use (p < 0.001). Secondary analyses with more restrictive ADHD diagnostic criteria revealed a lower prevalence rate (6.7%; 95%CI 5.2-12.9) with similar patterns of associated factors and negative outcomes.Conclusion: Our findings demonstrated that ADHD is a prevalent mental disorder in Mozambique, and it is associated with similar comorbid profiles, predisposing factors, and negative outcomes, as in other cultures.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139513536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychiatric features of two cases of anti-nmdar autoimmune encephalitis. 两例抗恩达尔自身免疫性脑炎患者的精神特征。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-01-22 DOI: 10.47626/1516-4446-2023-3430

Bárbara Ferreira Althoff, Anne Orgler Sordi, Lucas Primo de Carvalho Alves, Lisieux Elaine de Borba Telles

引用次数: 0

The association of blood biomarkers with cerebral white matter and myelin content in bipolar disorder: a systematic review. 血液生物标志物与双相情感障碍患者脑白质和髓鞘含量的关系：系统综述。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2023-12-20 DOI: 10.47626/1516-4446-2023-3267

Mohammad Ali, Renata Husnudinov, Bianca Wollenhaupt-Aguiar, Benicio N Frey

{"title":"The association of blood biomarkers with cerebral white matter and myelin content in bipolar disorder: a systematic review.","authors":"Mohammad Ali, Renata Husnudinov, Bianca Wollenhaupt-Aguiar, Benicio N Frey","doi":"10.47626/1516-4446-2023-3267","DOIUrl":"10.47626/1516-4446-2023-3267","url":null,"abstract":"Objectives: Evidence from diffusion tensor imaging (DTI) and postmortem studies has demonstrated white-matter (WM) deficits in bipolar disorder (BD). Changes in peripheral blood biomarkers have also been observed; however, studies evaluating the potential relationship between brain alterations and the periphery are scarce. The objective of this systematic review is to investigate the relationship between blood-based biomarkers and WM in BD.Methods: PubMed, Embase, and PsycINFO were used to conduct literature searches. Cross-sectional or longitudinal studies reporting original data which investigated both a blood-based biomarker and WM (by neuroimaging) in BD were included.Results: Of 3,750 studies retrieved, 23 were included. Several classes of biomarkers were found to have a significant relationship with WM in BD. These included cytokines and growth factors (interleukin-8 [IL-8], tumor necrosis factor alpha [TNF-a], and insulin-like growth factor binding protein 3 [IGFBP-3]), innate immune system (natural killer cells [NK]), metabolic markers (lipid hydroperoxidase, cholesterol, triglycerides), the kynurenine (Kyn) pathway (5-hydroxyindoleacetic acid, kynurenic acid [Kyna]), and various gene polymorphisms (serotonin-transporter-linked promoter region).Conclusion: This systematic review revealed that blood-based biomarkers are associated with markers of WM deficits observed in BD. Longitudinal studies investigating the potential clinical utility of these specific biomarkers are encouraged.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brazilian Psychiatric Association treatment guidelines for generalized anxiety disorder: perspectives on pharmacological and psychotherapeutic approaches. 巴西精神病学协会广泛性焦虑障碍(GAD)治疗指南。药理学和心理治疗方法。视角。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2023-11-13 DOI: 10.47626/1516-4446-2023-3235

Leonardo Baldaçara, Ana Beatriz Paschoal, Aldo Felipe Pinto, Fabiano Franca Loureiro, Luiz Antonio Vesco Gaiotto Antonio, Diogo de Lacerda Veiga, Thales Marcon Almeida, Diogo Cesar Dos Santos, Leandro Fernandes Malloy-Diniz, Marcelo Feijó de Mello, Andrea Feijó de Mello, Marsal Sanches, Lucas Marques Gandarela, Márcio Antonini Bernik, Antonio E Nardi, Antônio Geraldo da Silva, Ricardo R Uchida

{"title":"Brazilian Psychiatric Association treatment guidelines for generalized anxiety disorder: perspectives on pharmacological and psychotherapeutic approaches.","authors":"Leonardo Baldaçara, Ana Beatriz Paschoal, Aldo Felipe Pinto, Fabiano Franca Loureiro, Luiz Antonio Vesco Gaiotto Antonio, Diogo de Lacerda Veiga, Thales Marcon Almeida, Diogo Cesar Dos Santos, Leandro Fernandes Malloy-Diniz, Marcelo Feijó de Mello, Andrea Feijó de Mello, Marsal Sanches, Lucas Marques Gandarela, Márcio Antonini Bernik, Antonio E Nardi, Antônio Geraldo da Silva, Ricardo R Uchida","doi":"10.47626/1516-4446-2023-3235","DOIUrl":"10.47626/1516-4446-2023-3235","url":null,"abstract":"Generalized anxiety disorder is a highly prevalent mental disorder. Previous data indicate that more than 18 million Brazilians suffer from this condition. Traditionally, generalized anxiety disorder has been considered a mild mental health disorder, despite its links to lower life expectancy, cardiovascular disease, and suicide. The aim of this article is to combine elements of systematic and critical reviews to produce a synthesis of the best evidence about generalized anxiety disorder treatment. Systematic reviews, meta-analyses, and randomized controlled trials were included. The descriptor used in the search was \"generalized anxiety disorder,\" which resulted in 4,860 articles and seven other studies, of which 59 were selected. Antidepressants and benzodiazepines were indicated, as was pregabalin, and atypical antipsychotics, such as quetiapine, have been studied. Individual cognitive behavior therapy (third wave) has proven effective. There is extensive literature on many effective treatments for generalized anxiety disorder. The present review summarizes the therapeutic possibilities, emphasizing those available in Brazil. Further studies are needed to compare other available medications, assess psychotherapies and new treatments in greater depth, as well as to assess the ideal duration of therapy.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11302992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92156320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-cultural adaptation of the Mind-Wandering Questionnaire (MWQ) for Brazilian Portuguese and evidence of its validity. 巴西葡萄牙语走神问卷的跨文化适应与效度证据。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2023-11-23 DOI: 10.47626/1516-4446-2023-3312

Franciele Cristiane Peloso, Murilo Ricardo Zibetti, Antonio Egidio Nardi, Ramiro Figueiredo Catelan

{"title":"Cross-cultural adaptation of the Mind-Wandering Questionnaire (MWQ) for Brazilian Portuguese and evidence of its validity.","authors":"Franciele Cristiane Peloso, Murilo Ricardo Zibetti, Antonio Egidio Nardi, Ramiro Figueiredo Catelan","doi":"10.47626/1516-4446-2023-3312","DOIUrl":"10.47626/1516-4446-2023-3312","url":null,"abstract":"Objective: To adapt the Mind-Wandering Questionnaire (MWQ) for the Brazilian context and present evidence of validity based on its internal structure.Methods: A total of 2,682 Brazilian adults from different regions of the country took part in this study. Confirmatory factor analyses and multigroup confirmatory factor analyses (MGCFA) were performed to assess the factor structure of the MWQ. McDonald's omega (ω) was generated to provide reliability indexes.Results: The analyses demonstrated an adequate factor structure for the MWQ adapted to the Brazilian context, corroborating the original article's single-factor model and other adaptation studies. Furthermore, the results demonstrated the instrument's reliability in a Brazilian population (ω = 0.88).Conclusion: The MWQ is thus an adequate, reliable, and quickly administered instrument for those whose aim is to measure deliberate and spontaneous MW in Brazil.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of antidepressant use in Brazil: a systematic review with meta-analysis. 巴西使用抗抑郁药的普遍程度：系统回顾与荟萃分析。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2023-09-17 DOI: 10.47626/1516-4446-2023-3095

Gustavo Magno Baldin Tiguman, Rogério Hoefler, Marcus Tolentino Silva, Vanessa Gomes Lima, Inês Ribeiro-Vaz, Taís Freire Galvão

{"title":"Prevalence of antidepressant use in Brazil: a systematic review with meta-analysis.","authors":"Gustavo Magno Baldin Tiguman, Rogério Hoefler, Marcus Tolentino Silva, Vanessa Gomes Lima, Inês Ribeiro-Vaz, Taís Freire Galvão","doi":"10.47626/1516-4446-2023-3095","DOIUrl":"10.47626/1516-4446-2023-3095","url":null,"abstract":"Objectives: To estimate the prevalence of antidepressant use in Brazil.Methods: We conducted a systematic review with searches in MEDLINE, Embase, Scopus, LILACS, and SciELO up to May 2023. Two researchers independently selected studies, extracted data, and assessed the methodological quality. We pooled the prevalence of antidepressant use using meta-analyses of proportions (Freeman-Tukey transformation) and estimated heterogeneity by the I2 statistic. OR meta-analyses of antidepressant use by sex were calculated (men as reference) and between-study variation was explored by meta-regressions.Results: Out of 3,299 records retrieved, 23 studies published in 28 reports were included, with a total of 75,061 participants. The overall prevalence of antidepressant use was 4.0% (95%CI 2.7-5.6%; /² = 98.5%). Use of antidepressants in the previous 3 days was higher in women (12.0%; 95%CI 9.5-15.1%; /² = 0%) than men (4.6%; 95%CI 3.1-6.8%; /² = 0%) (p < 0.001; OR = 2.82; 95%CI 1.72-4.62). Gender differences were particularly higher for antidepressant use in the previous year (women: 2.3%; 95%CI 1.6-3.1; /² = 37.6% vs. men: 0.5%; 95%CI 0.2-1.0%; /² = 0%, p < 0.001; OR = 4.18; 95%CI 2.10-8.30). Between-study variation in the overall prevalence of antidepressant use significantly increased with mean participant age (p = 0.035; residual /² = 0%; regression coefficient = 0.003).Conclusion: Four out of every 100 Brazilians used antidepressants in this 3-decade assessment. Use increased with age and was more prevalent in women compared to men.Registration number: PROSPERO CRD42022345332.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10339069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do baseline participant characteristics impact the effectiveness of a mobile health intervention for depressive symptoms? A post-hoc subgroup analysis of the CONEMO trials. 基线特征会影响抑郁症状的治疗成功率吗？来自 CONEMO 的事后分组分析。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-01-30 DOI: 10.47626/1516-4446-2023-3172

Heloísa Garcia Claro, Paulo Rossi Menezes, Ivan Filipe Fernandes, Nadine Seward, Juan Jaime Miranda, Maria Giovana Borges Saidel, Aline Geovanna de Lima Baquete, Kate L Daley, Suzana Aschar, Daniela Vera Cruz, Hellen Carolina Martins Castro, Thais Rocha, Julieta Quayle, Tim J Peters, Ricardo Araya

{"title":"Do baseline participant characteristics impact the effectiveness of a mobile health intervention for depressive symptoms? A post-hoc subgroup analysis of the CONEMO trials.","authors":"Heloísa Garcia Claro, Paulo Rossi Menezes, Ivan Filipe Fernandes, Nadine Seward, Juan Jaime Miranda, Maria Giovana Borges Saidel, Aline Geovanna de Lima Baquete, Kate L Daley, Suzana Aschar, Daniela Vera Cruz, Hellen Carolina Martins Castro, Thais Rocha, Julieta Quayle, Tim J Peters, Ricardo Araya","doi":"10.47626/1516-4446-2023-3172","DOIUrl":"10.47626/1516-4446-2023-3172","url":null,"abstract":"Objective: To ascertain whether sociodemographic and health-related characteristics known from previous research to have a substantive impact on recovery from depression modified the effect of a digital intervention designed to improve depressive symptoms (CONEMO).Methods: The CONEMO study consisted of two randomized controlled trials, one conducted in Lima, Peru, and one in São Paulo, Brazil. As a secondary trial plan analysis, mixed logistic regression was used to explore interactions between the treatment arm and subgroups of interest defined by characteristics measured before randomization - suicidal ideation, race/color, age, gender, income, type of mobile phone, alcohol misuse, tobacco use, and diabetes/hypertension - in both trials. We estimated interaction effects between the treatment group and these subgroup factors for the secondary outcomes using linear mixed regression models.Results: Increased effects of the CONEMO intervention on the primary outcome (reduction of at least 50% in depressive symptom scores at 3-month follow-up) were observed among older and wealthier participants in the Lima trial (p = 0.030 and p = 0.001, respectively).Conclusion: There was no evidence of such differential effects in São Paulo, and no evidence of impact of any other secondary outcomes in either trial.Clinical trial registration: NCT02846662 (São Paulo, Brazil - SP), NCT03026426 (Lima, Peru - LI).","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium nitroprusside as an adjunctive treatment for schizophrenia reduces the Ndel1 oligopeptidase activity. 硝普钠作为精神分裂症的辅助治疗可降低Ndel1寡肽酶活性。

3区医学

Revista Brasileira de Psiquiatria Pub Date : 2023-11-23 DOI: 10.47626/1516-4446-2023-3315

João Victor Nani, Juliana Mayumi Ushirohira, Nicholas J Bradshaw, João Paulo Machado-de-Sousa, Jaime Eduardo Cecílio Hallak, Mirian A F Hayashi

{"title":"Sodium nitroprusside as an adjunctive treatment for schizophrenia reduces the Ndel1 oligopeptidase activity.","authors":"João Victor Nani, Juliana Mayumi Ushirohira, Nicholas J Bradshaw, João Paulo Machado-de-Sousa, Jaime Eduardo Cecílio Hallak, Mirian A F Hayashi","doi":"10.47626/1516-4446-2023-3315","DOIUrl":"https://doi.org/10.47626/1516-4446-2023-3315","url":null,"abstract":"Objective: Schizophrenia (SCZ) is a disabling disorder that continues to defy clinicians and researchers. We investigated the effects of sodium nitroprusside (sNP) in an animal model of SCZ and as an add-on therapy in patients and the relationship between treatment with sNP and activity of the nDel1 enzyme, whose involvement in the pathophysiology of the disorder has been suggested earlier.Methods: Ndel1 activity was measured following sNP infusions in spontaneously hypertensive rats (SHR; 2.5 or 5.0 mg/kg) and in a double-blind trial with SCZ patients (0.5 μg/kg/min).Results: Ndel1 activity was significantly reduced after sNP infusion in blood of SHR compared to controls, and in patients receiving sNP (t = 7.756, df = 97, p < 0.0001, dcohen = 1.44) compared to placebo. Reduced Ndel1 activity between baseline and the end of the infusion was only seen in patients after treatment with sNP.Conclusion: Our findings suggest that SCZ patients may benefit from adjunctive therapy with sNP and that the Ndel1 enzyme is a candidate biomarker of psychopathology in the disorder. Future research should look into the role of Ndel1 in SCZ and the potential effects of sNP and drugs with similar profiles of action in both animals and patients.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138295877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0