Revista Brasileira de Psiquiatria最新文献_第8页

Protective factors against depression in high-risk children and adolescents: a systematic review of longitudinal studies. 高危儿童和青少年抑郁症的保护因素：纵向研究的系统回顾。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-04-26 DOI: 10.47626/1516-4446-2023-3363

Bárbara Tietbohl-Santos, Augusto Ossamu Shintani, Bruno Braga Montezano, Paola Biazin, Giovanna Maiolli Signori, Rafaela Pulice, Giancarlo Franceschi Dalla Vecchia, Júlio César Bebber, Lucas Noronha, Ives Cavalcante Passos

{"title":"Protective factors against depression in high-risk children and adolescents: a systematic review of longitudinal studies.","authors":"Bárbara Tietbohl-Santos, Augusto Ossamu Shintani, Bruno Braga Montezano, Paola Biazin, Giovanna Maiolli Signori, Rafaela Pulice, Giancarlo Franceschi Dalla Vecchia, Júlio César Bebber, Lucas Noronha, Ives Cavalcante Passos","doi":"10.47626/1516-4446-2023-3363","DOIUrl":"10.47626/1516-4446-2023-3363","url":null,"abstract":"Objective: From a preventive perspective, this study reviewed the literature on protective factors against depressive symptoms in high-risk children and adolescents.Methods: We conducted a thorough search of the PubMed, APA, EMCare, and Embase databases for studies published between 1946 and August 25, 2023. We included only longitudinal studies that analyzed protective factors for depressive symptoms in high-risk children or adolescents, excluding cross-sectional studies, reviews, and pre-clinical studies.Results: A total of 29 studies with 62,405 participants were analyzed and 38 protective factors were identified. Positive individual characteristics, family factors, peer relationships, school-related aspects, neighborhood characteristics, and intrinsic religiosity were associated with improved depression outcomes.Conclusion: These findings have important implications for preventive strategies in this population. Addressing protective factors can help prevent depression and enhance lifetime mental health.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20233363"},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brazilian Psychiatric Association treatment guidelines for generalized anxiety disorder: perspectives on pharmacological and psychotherapeutic approaches. 巴西精神病学协会广泛性焦虑障碍(GAD)治疗指南。药理学和心理治疗方法。视角。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2023-11-13 DOI: 10.47626/1516-4446-2023-3235

Leonardo Baldaçara, Ana Beatriz Paschoal, Aldo Felipe Pinto, Fabiano Franca Loureiro, Luiz Antonio Vesco Gaiotto Antonio, Diogo de Lacerda Veiga, Thales Marcon Almeida, Diogo Cesar Dos Santos, Leandro Fernandes Malloy-Diniz, Marcelo Feijó de Mello, Andrea Feijó de Mello, Marsal Sanches, Lucas Marques Gandarela, Márcio Antonini Bernik, Antonio E Nardi, Antônio Geraldo da Silva, Ricardo R Uchida

{"title":"Brazilian Psychiatric Association treatment guidelines for generalized anxiety disorder: perspectives on pharmacological and psychotherapeutic approaches.","authors":"Leonardo Baldaçara, Ana Beatriz Paschoal, Aldo Felipe Pinto, Fabiano Franca Loureiro, Luiz Antonio Vesco Gaiotto Antonio, Diogo de Lacerda Veiga, Thales Marcon Almeida, Diogo Cesar Dos Santos, Leandro Fernandes Malloy-Diniz, Marcelo Feijó de Mello, Andrea Feijó de Mello, Marsal Sanches, Lucas Marques Gandarela, Márcio Antonini Bernik, Antonio E Nardi, Antônio Geraldo da Silva, Ricardo R Uchida","doi":"10.47626/1516-4446-2023-3235","DOIUrl":"10.47626/1516-4446-2023-3235","url":null,"abstract":"Generalized anxiety disorder is a highly prevalent mental disorder. Previous data indicate that more than 18 million Brazilians suffer from this condition. Traditionally, generalized anxiety disorder has been considered a mild mental health disorder, despite its links to lower life expectancy, cardiovascular disease, and suicide. The aim of this article is to combine elements of systematic and critical reviews to produce a synthesis of the best evidence about generalized anxiety disorder treatment. Systematic reviews, meta-analyses, and randomized controlled trials were included. The descriptor used in the search was \"generalized anxiety disorder,\" which resulted in 4,860 articles and seven other studies, of which 59 were selected. Antidepressants and benzodiazepines were indicated, as was pregabalin, and atypical antipsychotics, such as quetiapine, have been studied. Individual cognitive behavior therapy (third wave) has proven effective. There is extensive literature on many effective treatments for generalized anxiety disorder. The present review summarizes the therapeutic possibilities, emphasizing those available in Brazil. Further studies are needed to compare other available medications, assess psychotherapies and new treatments in greater depth, as well as to assess the ideal duration of therapy.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20233235"},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11302992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92156320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychiatric features of two cases of anti-nmdar autoimmune encephalitis. 两例抗恩达尔自身免疫性脑炎患者的精神特征。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-01-22 DOI: 10.47626/1516-4446-2023-3430

Bárbara Ferreira Althoff, Anne Orgler Sordi, Lucas Primo de Carvalho Alves, Lisieux Elaine de Borba Telles

引用次数: 0

Vitamin D serum concentration is prospectively associated with depressive symptoms in the EpiFloripa Aging Cohort Study: a structural equation modeling approach. EpiFloripa 老龄队列研究中维生素 D 血清浓度与抑郁症状的前瞻性关联：结构方程建模方法。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-01-21 DOI: 10.47626/1516-4446-2023-3153

Gilciane Ceolin, Júlia Dubois Moreira, Anna Quialheiro, Antônio Augusto Moura Silva, Eleonora d'Orsi, Débora Kurrle Rieger, Elisa Brietzke

{"title":"Vitamin D serum concentration is prospectively associated with depressive symptoms in the EpiFloripa Aging Cohort Study: a structural equation modeling approach.","authors":"Gilciane Ceolin, Júlia Dubois Moreira, Anna Quialheiro, Antônio Augusto Moura Silva, Eleonora d'Orsi, Débora Kurrle Rieger, Elisa Brietzke","doi":"10.47626/1516-4446-2023-3153","DOIUrl":"10.47626/1516-4446-2023-3153","url":null,"abstract":"Objective: To evaluate the direct, indirect, and total prospective effects of serum concentrations of 25-hydroxycholecalciferol (25[OH]D) on depressive symptoms in older adults.Methods: Data from the second (2013-2015) and third (2017-2019) waves of the EpiFloripa Aging Cohort Study (= 60 years) were analyzed. Depressive symptoms were assessed with the 15-item Geriatric Depression Scale. 25(OH)D levels were measured using the microparticle chemiluminescence method. A directed acyclic graph was constructed to identify the minimum set of adjustments. Structural equation modeling analysis was used to determine the effects of 25(OH)D on depressive symptoms.Results: Data from 574 older adults (63.1% female) were analyzed. In the follow-up (n=390), 16.2% of them presented severe depressive symptoms (= 6 points). Structural equation modeling analysis revealed that 25(OH)D had a small direct negative effect (ß = -0.11, p < 0.05) and an overall negative effect (ß = -0.13; p < 0.05) on depressive symptoms in wave 3 (increased 25[OH]D led to decreased depressive symptoms). No direct or indirect effect on depressive symptoms was found in wave 2.Conclusion: Our findings indicate a prospective association between 25(OH)D and depressive symptoms, suggesting a long-term effect in older adults from southern Brazil.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20233153"},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11474441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139513567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association of blood biomarkers with cerebral white matter and myelin content in bipolar disorder: a systematic review. 血液生物标志物与双相情感障碍患者脑白质和髓鞘含量的关系：系统综述。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2023-12-20 DOI: 10.47626/1516-4446-2023-3267

Mohammad Ali, Renata Husnudinov, Bianca Wollenhaupt-Aguiar, Benicio N Frey

{"title":"The association of blood biomarkers with cerebral white matter and myelin content in bipolar disorder: a systematic review.","authors":"Mohammad Ali, Renata Husnudinov, Bianca Wollenhaupt-Aguiar, Benicio N Frey","doi":"10.47626/1516-4446-2023-3267","DOIUrl":"10.47626/1516-4446-2023-3267","url":null,"abstract":"Objectives: Evidence from diffusion tensor imaging (DTI) and postmortem studies has demonstrated white-matter (WM) deficits in bipolar disorder (BD). Changes in peripheral blood biomarkers have also been observed; however, studies evaluating the potential relationship between brain alterations and the periphery are scarce. The objective of this systematic review is to investigate the relationship between blood-based biomarkers and WM in BD.Methods: PubMed, Embase, and PsycINFO were used to conduct literature searches. Cross-sectional or longitudinal studies reporting original data which investigated both a blood-based biomarker and WM (by neuroimaging) in BD were included.Results: Of 3,750 studies retrieved, 23 were included. Several classes of biomarkers were found to have a significant relationship with WM in BD. These included cytokines and growth factors (interleukin-8 [IL-8], tumor necrosis factor alpha [TNF-a], and insulin-like growth factor binding protein 3 [IGFBP-3]), innate immune system (natural killer cells [NK]), metabolic markers (lipid hydroperoxidase, cholesterol, triglycerides), the kynurenine (Kyn) pathway (5-hydroxyindoleacetic acid, kynurenic acid [Kyna]), and various gene polymorphisms (serotonin-transporter-linked promoter region).Conclusion: This systematic review revealed that blood-based biomarkers are associated with markers of WM deficits observed in BD. Longitudinal studies investigating the potential clinical utility of these specific biomarkers are encouraged.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":"46 ","pages":"e20233267"},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging the gap: psychiatry's role in the new era of obesity treatment. 缩小差距：精神病学在肥胖症治疗新时代中的作用》（Bridging the Gap: Psychiatry's Role in the New Era of Obesity Treatment）。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-04-08 DOI: 10.47626/1516-4446-2024-3604

Jose Carlos Appolinario, Phillipa Hay, Walmir Coutinho

引用次数: 0

A network analysis of early trauma and impulsive behavior in individuals with alcohol, cocaine, and polysubstance use disorder. 对酒精和快克可卡因单一和多重依赖者早期创伤和冲动行为的网络分析。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-03-06 DOI: 10.47626/1516-4446-2023-3265

Vanessa Loss Volpatto, Jaqueline Bohrer Schuch, Francisco Diego Rabelo-da-Ponte, Ellen Mello Borgonhi, Júlia Corrêa de Freitas, Felipe Ornell, Ramon Agostini Proença, Rodrigo Pereira Pio, Lisia von Diemen, Felix Henrique Paim Kessler

{"title":"A network analysis of early trauma and impulsive behavior in individuals with alcohol, cocaine, and polysubstance use disorder.","authors":"Vanessa Loss Volpatto, Jaqueline Bohrer Schuch, Francisco Diego Rabelo-da-Ponte, Ellen Mello Borgonhi, Júlia Corrêa de Freitas, Felipe Ornell, Ramon Agostini Proença, Rodrigo Pereira Pio, Lisia von Diemen, Felix Henrique Paim Kessler","doi":"10.47626/1516-4446-2023-3265","DOIUrl":"10.47626/1516-4446-2023-3265","url":null,"abstract":"Objective: This study investigated the relationship between impulsivity and early trauma through a network analysis in individuals diagnosed with different substance use disorders.Methods: In a cross-sectional design, the sample included 556 men with substance use disorders (195 with alcohol use, 157 with cocaine/crack use, and 214 with polysubstance use). Early trauma and impulsive behavior were assessed using the Childhood Trauma Questionnaire and the Barratt Impulsiveness Scale, respectively. The connection between trauma and impulsivity was assessed using network analysis through a fused graphical lasso algorithm.Results: No connection was observed between impulsivity and trauma networks in individuals with alcohol use disorder. In those with cocaine use disorder, networks were linked through the motor domain and sexual abuse nodes. Inverse connections were observed between the emotional neglect node and perseverance, but not the non-planning node. In polysubstance use, the connection between impulsivity and trauma networks was weak, with the cognitive complexity node connecting to the trauma network through physical abuse. There connections were inversely proportional between the motor domain and emotional neglect nodes, as well as between cognitive instability and physical neglect.Conclusion: Our results suggest that the relationship between the type of early (childhood) trauma and the expression of impulsivity could lead to different substance use profiles.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20233265"},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11474448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-cultural adaptation of the Mind-Wandering Questionnaire (MWQ) for Brazilian Portuguese and evidence of its validity. 巴西葡萄牙语走神问卷的跨文化适应与效度证据。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2023-11-23 DOI: 10.47626/1516-4446-2023-3312

Franciele Cristiane Peloso, Murilo Ricardo Zibetti, Antonio Egidio Nardi, Ramiro Figueiredo Catelan

{"title":"Cross-cultural adaptation of the Mind-Wandering Questionnaire (MWQ) for Brazilian Portuguese and evidence of its validity.","authors":"Franciele Cristiane Peloso, Murilo Ricardo Zibetti, Antonio Egidio Nardi, Ramiro Figueiredo Catelan","doi":"10.47626/1516-4446-2023-3312","DOIUrl":"10.47626/1516-4446-2023-3312","url":null,"abstract":"Objective: To adapt the Mind-Wandering Questionnaire (MWQ) for the Brazilian context and present evidence of validity based on its internal structure.Methods: A total of 2,682 Brazilian adults from different regions of the country took part in this study. Confirmatory factor analyses and multigroup confirmatory factor analyses (MGCFA) were performed to assess the factor structure of the MWQ. McDonald's omega (ω) was generated to provide reliability indexes.Results: The analyses demonstrated an adequate factor structure for the MWQ adapted to the Brazilian context, corroborating the original article's single-factor model and other adaptation studies. Furthermore, the results demonstrated the instrument's reliability in a Brazilian population (ω = 0.88).Conclusion: The MWQ is thus an adequate, reliable, and quickly administered instrument for those whose aim is to measure deliberate and spontaneous MW in Brazil.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20233312"},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of antidepressant use in Brazil: a systematic review with meta-analysis. 巴西使用抗抑郁药的普遍程度：系统回顾与荟萃分析。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2023-09-17 DOI: 10.47626/1516-4446-2023-3095

Gustavo Magno Baldin Tiguman, Rogério Hoefler, Marcus Tolentino Silva, Vanessa Gomes Lima, Inês Ribeiro-Vaz, Taís Freire Galvão

{"title":"Prevalence of antidepressant use in Brazil: a systematic review with meta-analysis.","authors":"Gustavo Magno Baldin Tiguman, Rogério Hoefler, Marcus Tolentino Silva, Vanessa Gomes Lima, Inês Ribeiro-Vaz, Taís Freire Galvão","doi":"10.47626/1516-4446-2023-3095","DOIUrl":"10.47626/1516-4446-2023-3095","url":null,"abstract":"Objectives: To estimate the prevalence of antidepressant use in Brazil.Methods: We conducted a systematic review with searches in MEDLINE, Embase, Scopus, LILACS, and SciELO up to May 2023. Two researchers independently selected studies, extracted data, and assessed the methodological quality. We pooled the prevalence of antidepressant use using meta-analyses of proportions (Freeman-Tukey transformation) and estimated heterogeneity by the I2 statistic. OR meta-analyses of antidepressant use by sex were calculated (men as reference) and between-study variation was explored by meta-regressions.Results: Out of 3,299 records retrieved, 23 studies published in 28 reports were included, with a total of 75,061 participants. The overall prevalence of antidepressant use was 4.0% (95%CI 2.7-5.6%; /² = 98.5%). Use of antidepressants in the previous 3 days was higher in women (12.0%; 95%CI 9.5-15.1%; /² = 0%) than men (4.6%; 95%CI 3.1-6.8%; /² = 0%) (p < 0.001; OR = 2.82; 95%CI 1.72-4.62). Gender differences were particularly higher for antidepressant use in the previous year (women: 2.3%; 95%CI 1.6-3.1; /² = 37.6% vs. men: 0.5%; 95%CI 0.2-1.0%; /² = 0%, p < 0.001; OR = 4.18; 95%CI 2.10-8.30). Between-study variation in the overall prevalence of antidepressant use significantly increased with mean participant age (p = 0.035; residual /² = 0%; regression coefficient = 0.003).Conclusion: Four out of every 100 Brazilians used antidepressants in this 3-decade assessment. Use increased with age and was more prevalent in women compared to men.Registration number: PROSPERO CRD42022345332.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20233095"},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10339069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium nitroprusside as an adjunctive treatment for schizophrenia reduces Ndel1 oligopeptidase activity. 硝普钠作为精神分裂症的辅助治疗可降低Ndel1寡肽酶活性。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2023-11-23 DOI: 10.47626/1516-4446-2023-3315

João Victor Nani, Juliana Mayumi Ushirohira, Nicholas J Bradshaw, João Paulo Machado-de-Sousa, Jaime Eduardo Cecílio Hallak, Mirian A F Hayashi

{"title":"Sodium nitroprusside as an adjunctive treatment for schizophrenia reduces Ndel1 oligopeptidase activity.","authors":"João Victor Nani, Juliana Mayumi Ushirohira, Nicholas J Bradshaw, João Paulo Machado-de-Sousa, Jaime Eduardo Cecílio Hallak, Mirian A F Hayashi","doi":"10.47626/1516-4446-2023-3315","DOIUrl":"10.47626/1516-4446-2023-3315","url":null,"abstract":"Objective: To assess nuclear distribution element-like 1 (Ndel1) enzyme activity following acute administration of sodium nitroprusside (sNP) in a rodent model of schizophrenia (SCZ) and in a cohort of chronic SCZ patients.Methods: Ndel1 activity was measured following sNP infusions in spontaneously hypertensive rats (SHR) (2.5 or 5.0 mg/kg) and in a double-blind randomized trial with 15 SCZ patients (0.5 µg/kg/min). Patients were randomized into two groups (group I: n=7; group II: n=8), with one group receiving placebo and the other sNP in phase A. In phase B, the groups switched treatments. sNP was administered as an infusion of 0.5 µg/kg/min, for 4 h, while placebo was a 5% glucose solution infused under the same conditions. The infusions were administered once weekly over 4 weeks. Psychopathology was assessed using the 18-item figure 5 (BPRS-18 - Bech's version) and the negative subscale of the Positive and Negative Syndrome Scale.Results: Ndel1 activity was significantly reduced after sNP infusion in SHR and in patients receiving sNP (t = 7.756, degrees of freedom [df] = 97, p < 0.0001, dcohen=1.44) compared to placebo. Reduced Ndel1 activity from baseline to the end of infusion was only seen in patients after treatment with sNP.Conclusion: SCZ patients may benefit from adjunctive therapy with sNP and that the Ndel1 enzyme is a candidate biomarker of psychopathology in the disorder. Future research should look into the role of Ndel1 in SCZ and the potential effects of sNP and drugs with similar profiles of action in both animals and patients.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20233315"},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11474453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138295877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0