Revista Brasileira de Psiquiatria最新文献_第9页

The interaction between polygenic risk score and trauma affects the likelihood of post-traumatic stress disorder in female victims of sexual assault. 创伤后应激障碍-PRS 与创伤之间的相互作用会影响性侵犯女性受害者患创伤后应激障碍的可能性。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-03-11 DOI: 10.47626/1516-4446-2023-3335

Amanda Victória Gomes Bugiga, Carolina Muniz Carvalho, Adrielle Martins Oliveira, Bruno Messina Coimbra, Samar Nasser Chehimi, Evelin Aline Zanardo, Leslie Domenici Kulikowski, Andrea Feijó Mello, Vanessa Kiyomi Ota, Marcelo Feijo Mello, Sintia Iole Belangero

{"title":"The interaction between polygenic risk score and trauma affects the likelihood of post-traumatic stress disorder in female victims of sexual assault.","authors":"Amanda Victória Gomes Bugiga, Carolina Muniz Carvalho, Adrielle Martins Oliveira, Bruno Messina Coimbra, Samar Nasser Chehimi, Evelin Aline Zanardo, Leslie Domenici Kulikowski, Andrea Feijó Mello, Vanessa Kiyomi Ota, Marcelo Feijo Mello, Sintia Iole Belangero","doi":"10.47626/1516-4446-2023-3335","DOIUrl":"10.47626/1516-4446-2023-3335","url":null,"abstract":"Objective: Post-traumatic stress disorder (PTSD) is triggered by traumatic events, but genetic vulnerability and a history of childhood trauma may also increase the risk of PTSD onset. Thus, we investigated the interaction between genetic susceptibility according to polygenic risk score (PRS), and traumatic events.Methods: We evaluated 68 women with PTSD who had been sexually assaulted and 63 healthy controls with no history of sexual assault. DNA was genotyped using the Infinium Global Screening Array (Illumina, San Diego, CA, USA), and PRS analysis was performed using PRSice. Logistic regression models were also used to determine the interaction between childhood trauma, traumatic life events, and PRS and how they contribute to PTSD risk.Results: We found a significant association between PRS, childhood trauma (p = 0.03; OR = 1.241), and PTSD. There was also an interaction between PRS, traumatic life events, and childhood trauma, particularly physical and emotional neglect (p = 0.028; OR = 1.010). When examining neglect separately, we found a modest association between emotional neglect and PTSD (p = 0.014; OR = 1.086).Conclusion: Our findings highlight the importance of considering genetic vulnerability and traumatic experiences in understanding the etiology of PTSD.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20233335"},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11474442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The S20 Brazilian Mental Health Report for Building a Just World and a Sustainable Planet: Part II. 建设公正世界和可持续地球的 S20 巴西心理健康报告》：第二部分

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-06-14 DOI: 10.47626/1516-4446-2024-3707

Jair de Jesus Mari, Flávio Kapczinski, André Russowsky Brunoni, Ary Gadelha, Daniel Prates-Baldez, Eurípedes Constantino Miguel, Fulvio A Scorza, Arthur Caye, Laiana A Quagliato, Raquel B De Boni, Giovanni Salum, Antonio E Nardi

{"title":"The S20 Brazilian Mental Health Report for Building a Just World and a Sustainable Planet: Part II.","authors":"Jair de Jesus Mari, Flávio Kapczinski, André Russowsky Brunoni, Ary Gadelha, Daniel Prates-Baldez, Eurípedes Constantino Miguel, Fulvio A Scorza, Arthur Caye, Laiana A Quagliato, Raquel B De Boni, Giovanni Salum, Antonio E Nardi","doi":"10.47626/1516-4446-2024-3707","DOIUrl":"10.47626/1516-4446-2024-3707","url":null,"abstract":"This is the second part of the Brazilian S20 mental health report. The mental health working group is dedicated to leveraging scientific insights to foster innovation and propose actionable recommendations for implementation in Brazil and participating countries. In addressing the heightened mental health challenges in a post-pandemic world, strategies should encompass several key elements. This second part of the S20 Brazilian Mental Health Report will delve into some of these elements, including: the impact of climate change on mental health, the influence of environmental factors on neurodevelopmental disorders, the intersection of serious mental illness and precision psychiatry, the co-occurrence of physical and mental disorders, advancements in biomarkers for mental disorders, the use of digital health in mental health care, the implementation of interventional psychiatry, and the design of innovative mental health systems that integrate principles of innovation and human rights. Reassessing the treatment settings for psychiatric patients in general hospitals, where their mental health and physical needs are addressed, should be prioritized in mental health policy. As the S20 countries prepare for the future, we need principles that can advance innovation, uphold human rights, and strive for the highest standards in mental health care.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243707"},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CORRIGENDUM. CORRIGENDUM.

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 DOI: 10.47626/1516-4446-2024-3751

引用次数: 0

Over a third of treatment-seekers from São Paulo's Crackland report recent use of synthetic cannabinoids. 在圣保罗克拉克兰寻求戒毒治疗的患者中，每十人中就有两人报告最近使用过合成大麻素。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-06-21 DOI: 10.47626/1516-4446-2023-3234

Clarice Sandi Madruga, Quirino Cordeiro, Claudio Jerônimo da Silva, Aline Correa de Araujo, Danilo Silveira Seabra, Ronaldo R Laranjeira

引用次数: 0

Do baseline participant characteristics impact the effectiveness of a mobile health intervention for depressive symptoms? A post-hoc subgroup analysis of the CONEMO trials. 基线特征会影响抑郁症状的治疗成功率吗？来自 CONEMO 的事后分组分析。

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-01-30 DOI: 10.47626/1516-4446-2023-3172

Heloísa Garcia Claro, Paulo Rossi Menezes, Ivan Filipe Fernandes, Nadine Seward, Juan Jaime Miranda, Maria Giovana Borges Saidel, Aline Geovanna de Lima Baquete, Kate L Daley, Suzana Aschar, Daniela Vera Cruz, Hellen Carolina Martins Castro, Thais Rocha, Julieta Quayle, Tim J Peters, Ricardo Araya

{"title":"Do baseline participant characteristics impact the effectiveness of a mobile health intervention for depressive symptoms? A post-hoc subgroup analysis of the CONEMO trials.","authors":"Heloísa Garcia Claro, Paulo Rossi Menezes, Ivan Filipe Fernandes, Nadine Seward, Juan Jaime Miranda, Maria Giovana Borges Saidel, Aline Geovanna de Lima Baquete, Kate L Daley, Suzana Aschar, Daniela Vera Cruz, Hellen Carolina Martins Castro, Thais Rocha, Julieta Quayle, Tim J Peters, Ricardo Araya","doi":"10.47626/1516-4446-2023-3172","DOIUrl":"10.47626/1516-4446-2023-3172","url":null,"abstract":"Objective: To ascertain whether sociodemographic and health-related characteristics known from previous research to have a substantive impact on recovery from depression modified the effect of a digital intervention designed to improve depressive symptoms (CONEMO).Methods: The CONEMO study consisted of two randomized controlled trials, one conducted in Lima, Peru, and one in São Paulo, Brazil. As a secondary trial plan analysis, mixed logistic regression was used to explore interactions between the treatment arm and subgroups of interest defined by characteristics measured before randomization - suicidal ideation, race/color, age, gender, income, type of mobile phone, alcohol misuse, tobacco use, and diabetes/hypertension - in both trials. We estimated interaction effects between the treatment group and these subgroup factors for the secondary outcomes using linear mixed regression models.Results: Increased effects of the CONEMO intervention on the primary outcome (reduction of at least 50% in depressive symptom scores at 3-month follow-up) were observed among older and wealthier participants in the Lima trial (p = 0.030 and p = 0.001, respectively).Conclusion: There was no evidence of such differential effects in São Paulo, and no evidence of impact of any other secondary outcomes in either trial.Clinical trial registration: NCT02846662 (São Paulo, Brazil - SP), NCT03026426 (Lima, Peru - LI).","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20233172"},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The S20 Brazilian Mental Health Report for building a just world and a sustainable planet: Part I. 建设公正世界和可持续地球的 S20 巴西心理健康报告》：第一部分

IF 3.6 3区医学

Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2024-06-14 DOI: 10.47626/1516-4446-2024-3706

Jair de Jesus Mari, Christian Kieling, Cleusa Pinheiro Ferri, João Mauricio Castaldelli-Maia, Naielly Rodrigues da Silva, Marcelo Feijó de Mello, Thiago M Fidalgo, Zila M Sanchez, Giovanni Salum, Naomar Almeida-Filho

{"title":"The S20 Brazilian Mental Health Report for building a just world and a sustainable planet: Part I.","authors":"Jair de Jesus Mari, Christian Kieling, Cleusa Pinheiro Ferri, João Mauricio Castaldelli-Maia, Naielly Rodrigues da Silva, Marcelo Feijó de Mello, Thiago M Fidalgo, Zila M Sanchez, Giovanni Salum, Naomar Almeida-Filho","doi":"10.47626/1516-4446-2024-3706","DOIUrl":"10.47626/1516-4446-2024-3706","url":null,"abstract":"This is the first part of two documents prepared by experts for the Brazilian S20 mental health report. These reports outline strategies aimed at addressing the exacerbated mental health challenges arising from a post-pandemic world. Ongoing psychiatric epidemiology research has yielded evidence linking mental health with intricate social determinants, including gender, race/ethnicity, racism, socioeconomic status, social deprivation, and employment, among others. More recently, the focus has expanded to also encompass violence and social oppression. By prioritizing prevention and early intervention, harnessing technology, and fostering community support, we can mitigate the long-term impact of mental disorders emerging in life. Utilizing evidence-based practices and forging partnerships between the health and education sectors, S20 countries can promote health and safety of their student population, thereby paving the way for a more promising future for the next generations. The first document focuses on addressing the mental health concerns of vulnerable populations, catering to the needs of children, youth, and aging populations, assessing the current state of alcohol and drug addictions, scaling up psychosocial interventions in primary care, exploring the potential integration of health and educational systems, and emphasizing the imperative adoption of human rights in mental health policies.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"e20243706"},"PeriodicalIF":3.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of declarative memory profile in panic disorder patients: a machine learning-based approach. 惊恐障碍患者声明性记忆谱的预测：一种基于机器学习的方法。

3区医学

Revista Brasileira de Psiquiatria Pub Date : 2023-11-01 Epub Date: 2023-10-25 DOI: 10.47626/1516-4446-2023-3291

Felipe Dalvi-Garcia, Laiana Azevedo Quagliato, Donald J Bearden, Antonio Egidio Nardi

{"title":"Prediction of declarative memory profile in panic disorder patients: a machine learning-based approach.","authors":"Felipe Dalvi-Garcia, Laiana Azevedo Quagliato, Donald J Bearden, Antonio Egidio Nardi","doi":"10.47626/1516-4446-2023-3291","DOIUrl":"10.47626/1516-4446-2023-3291","url":null,"abstract":"Objective: To develop a classification framework based on random forest (RF) modeling to outline the declarative memory profile of patients with panic disorder (PD) compared to a healthy control sample.Methods: We developed RF models to classify the declarative memory profile of PD patients in comparison to a healthy control sample using the Rey Auditory Verbal Learning Test (RAVLT). For this study, a total of 299 patients with PD living in the city of Rio de Janeiro (70.9% females, age 39.9 ± 7.3 years old) were recruited through clinician referrals or self/family referrals.Results: Our RF models successfully predicted declarative memory profiles in patients with PD based on RAVLT scores (lowest area under the curve [AUC] of 0.979, for classification; highest root mean squared percentage [RMSPE] of 17.2%, for regression) using relatively bias-free clinical data, such as sex, age, and body mass index (BMI).Conclusions: Our findings also suggested that BMI, used as a proxy for diet and exercises habits, plays an important role in declarative memory. Our framework can be extended and used as a prospective tool to classify and examine associations between clinical features and declarative memory in PD patients.","PeriodicalId":21244,"journal":{"name":"Revista Brasileira de Psiquiatria","volume":" ","pages":"482-490"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10897768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50162746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progressive multifocal leukoencephalopathy cannot be due to liver cirrhosis alone. 进行性多灶性白质脑病不能仅由肝硬化引起。

3区医学

Revista Brasileira de Psiquiatria Pub Date : 2023-11-01 Epub Date: 2023-10-19 DOI: 10.47626/1516-4446-2023-3375

Fulvio A Scorza, Josef Finsterer

引用次数: 0

Is maintenance needed for patients who responded to acute TMS therapy? 对急性 TMS 治疗有反应的患者是否需要维持治疗？

3区医学

Revista Brasileira de Psiquiatria Pub Date : 2023-11-01 Epub Date: 2023-09-17 DOI: 10.47626/1516-4446-2023-0052

Bashar Asir, Andrea Boscutti, João Quevedo

引用次数: 0

Fifty years of research on cannabidiol (CBD) as an anticonvulsant: The legacy of Brazilian groups. 大麻二酚(CBD)作为抗惊厥药的50年研究:巴西团体的遗产。

3区医学

Revista Brasileira de Psiquiatria Pub Date : 2023-11-01 Epub Date: 2023-11-25 DOI: 10.47626/1516-4446-2023-3377

Antonio Waldo Zuardi, José Alexandre Crippa

引用次数: 0