Evaluation of Galectin-1 and Galectin-3 levels in patients with bipolar disorder: Is Galectin-3 associated with treatment response?

IF 3.6 3区医学 Q1 PSYCHIATRY

Revista Brasileira de Psiquiatria Pub Date : 2024-05-20 DOI:10.47626/1516-4446-2024-3535

Meryem Yüksel Aytekin, Aybeniz Civan Kahve, Rabia Nazik Ekinci, Arzu Sakallı Nural, Işık Batuhan Çakmak, Nagihan Ayaz Naycı, Erol Göka

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引用次数: 0

Abstract

Introduction: Galectins (Gal) were linked with inflammatory responses in the central nervous system, may play an important role in the pathogenesis of BD.In this study,we aimed to investigate whether serum Gal-1 and Gal-3 levels are related to BD.

Methods: 36 patients diagnosed with BD were included.C-Reactive Protein(CRP),Gal-1,Gal-3 blood levels were evaluated on the first day of hospitalization and the third week of treatment and compared with 41 healthy controls.The severity of the illness was evaluated with the Young Mania Rating Scale (YMRS).

Results: CRP levels of BD patients at hospitalization were significantly higher than the third week of treatment and healthy controls.Gal-1 levels on the first day of hospitalization and the third week of treatment were found higher than the healthy controls.There was no significant difference in Gal-3 levels of the patients on the day of hospitalization compared to healthy controls;at the end of the 3rd week of treatment,Gal-3 was statistically significantly higher than the first day of hospitalization.

Conclusion: Our study is valuable in that it is the first study to show the change in Gal levels after treatment and to evaluate the role of Gal in BD.Gal-1 may play roles in the pathophysiology of BD.Gal-3 may be a biomarker candidate for the evaluation of the treatment response.

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评估双相情感障碍患者的 Galectin-1 和 Galectin-3 水平：Galectin-3 是否与治疗反应有关？

引言本研究旨在探讨血清Gal-1和Gal-3水平是否与BD有关。方法：纳入36例确诊为BD的患者，评估住院第一天和治疗第三周的C-反应蛋白（CRP）、Gal-1、Gal-3血药浓度，并与41例健康对照组进行比较：结果：BD患者住院时的CRP水平明显高于治疗第3周和健康对照组；住院第一天和治疗第3周的Gal-1水平均高于健康对照组；住院当天患者的Gal-3水平与健康对照组相比无明显差异；治疗第3周结束时，Gal-3在统计学上明显高于住院第一天：Gal-1可能在BD的病理生理学中发挥作用，Gal-3可能是评估治疗反应的候选生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Brasileira de Psiquiatria 医学-精神病学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Revista Brasileira de Psiquiatria (RBP) is the official organ of the Associação Brasileira de Psiquiatria (ABP - Brazilian Association of Psychiatry). The Brazilian Journal of Psychiatry is a bimonthly publication that aims to publish original manuscripts in all areas of psychiatry, including public health, clinical epidemiology, basic science, and mental health problems. The journal is fully open access, and there are no article processing or publication fees. Articles must be written in English.