Restorative neurology and neuroscience最新文献

{"title":"Cognitive Network Changes After Exposure to Haptic Vibrotactile Trigger Technology: Results From The ENHANCE Study","authors":"John J Haddad, Mark DeBrincat, Duane M North, Jay Dhaliwal, Peter Hurwitz","doi":"10.33425/2692-7918.1054","DOIUrl":"https://doi.org/10.33425/2692-7918.1054","url":null,"abstract":"The conceptual framework of cognitive networks, or cognits, represents a system of working memory, especially long-term memory arrays that are intrinsically designed to attain certain behavioral ends and that are activated by a neural structure. Despite the fact that cognitions can be used in a plethora of systems, current technologies allow manipulations of the central nervous system (CNS) to execute certain sensory and motor functions. Sensation and tactual perception by the skin are an innate mechanism for human survival and represent our adaptive somatosensorial ability to apprehend information via haptics—the active touch for object recognition and perception by higher centers of the brain. The somatosensation, which is identified by a set of channels and receptors sensitive to a variety of stimuli (thermal, tactile, and mechanical), is critical to survival, balance control, cognition, and pain modulation. Cognits are cutting-edge tools and modalities that provide a landscape of theoretical assets, evidencebased experimental protocols, computational intelligence schemes, and direct empirical modalities that facilitate the understanding of the complex functionalities of the human brain. By evaluating neuroimaging data after somatosensory stimulation and collected via electroencephalogram (EEG), cognition response and change can be obtained that allows researchers to gain a better understanding of emerging scientific approaches aimed at understanding human behavioral outcomes. An emerging technology, haptic vibrotactile trigger technology (VTT), incorporates somatosensory patterns in compression sleeves. eSmartr Smart Compression Sleeves (Srysty Holdings Inc., Mississauga, ON, Canada) with VTT and its Cognitive Boost Technology (CBT) pattern is designed to optimize neural communications for improved mindful wellness. This technology has also been incorporated into patches, braces, apparel (socks), wrist bands, and other routes of delivery. Mindful wellness is considered an outcome of somatosensory intervention that modulates the behavioral responses associated with cognitive networks. Currently, there is limited research exploring these modalities, exposing the need to study new technologies and their influence on somatosensory pathways and cognitive networks. The purpose of this IRB-approved study was to explore the effects of forearm VTT stimulation patterns on cognitive networks by comparing a baseline EEG to an EEG after placing a sleeve incorporating VTT on the right or left forearm of adult healthy individuals. Materials and methods: A baseline EEG was recorded over 5 minutes from 19 scalp locations on 20 subjects ranging in age from 17.6 years to 41.9 years (n=7 females, 13 males). The subject’s dominant arm was then fitted with the eSmartr Smart Compression Sleeve for 20 minutes and another 5-minute EEG was recorded. Both the LORETA (Low Resolution Electromagnetic Tomography Analysis) inverse solution and a power spectral analysis of t","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"37 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136227696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Shadow Psyche in Leadership & Decision- Making: A Praxeology Perspective on the Collective Unconscious Psyche","authors":"Rose-Marie Boylan","doi":"10.33425/2692-7918.1053","DOIUrl":"https://doi.org/10.33425/2692-7918.1053","url":null,"abstract":"","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"38 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136227692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Compression Severity and Hand Dexterity, Sleep, Quality of Life, Neuropathic Pain, and Anxiety-Depression in Patients with Carpal and Cubital Tunnel Syndrome","authors":"Buket Özkara Yılmaz","doi":"10.33425/2692-7918.1050","DOIUrl":"https://doi.org/10.33425/2692-7918.1050","url":null,"abstract":"Objective: Carpal and cubital tunnel syndromes are common entrapment neuropathies [1]. Some previous studies showed that carpal tunnel syndrome and, to a lesser extent, cubital tunnel syndrome can impair sleep and quality of life [2-4]. But there are only few studies comparing these two syndromes [5]. However, no study, which evaluates hand dexterity, sleep quality, quality of life, and neuropathic pain in relation to the severity of compression determined by Electroneurography (ENMG) in both syndromes, could be found in the literature. Thus, it was aimed in the present study to investigate the relationship between hand dexterity, sleep quality, quality of life, neuropathic pain, and anxiety-depression symptoms with different levels of compression severity in patients clinically and electro-physiologically diagnosed with carpal tunnel syndrome and cubital tunnel syndrome. Materials and methods: This study involved patients, who applied to the ENMG laboratory and were18 years or older and clinically and electro-physiologically diagnosed with carpal tunnel syndrome and cubital tunnel syndrome. The sociodemographic and clinical data of the patients who agreed to participate in the study were recorded. Carpal tunnel syndrome was classified as mild, moderate, and severe by using the American Association of Electrodiagnostic Medicine Classification [12] based on electrophysiological data, whereas the classification of cubital tunnel syndrome was performed by using the electrodiagnostic grading system created by Zeidman and Pandey based on the American Association of Electrodiagnostic Medicine practice guidelines [13]. The Pittsburgh Sleep Quality Index [14,15] and Epworth Sleepiness Scale [16,17] were used in evaluating the sleep quality of the patients, the EuroQuol-5D Quality of Life Scale [18,19] for quality of life, the 4-item neuropathic pain scale [20,21] for neuropathic pain, the Hospital Anxiety and Depression Scale [22,23] for anxiety and depression levels, and the 9-Hole Peg Test [24] for hand dexterity. After the forms were filled in, the data of the patients having carpal tunnel syndrome and those of patients having cubital tunnel syndrome were compared statistically. Moreover, after staging them as mild, moderate, and severe, the findings of patients in both groups were compared within each group, and their relationships were investigated. Results: Sleep disorders, neuropathic pain, depression, and anxiety disorders were observed to be much more prevalent among patients with CTS when compared to the patients with CuTS and the severity of these disorders increases together with an increase in the severity of the disease. It was also determined that CTS patients lag behind CuTS patients in fine motor skills. Conclusion: It should be noted that all of these parameters negatively affect the quality of life of patients. Early physiotherapy and rehabilitation can be beneficial in the treatment of patients and can contribute to their quality of l","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Retina and Optic Discs of Patients with Chronic and Episodic Migraine using Optical Coherence Tomography and Optical Coherence Tomography Angiography","authors":"Buket Yılmaz,, Ali Karnaz","doi":"10.33425/2692-7918.1048","DOIUrl":"https://doi.org/10.33425/2692-7918.1048","url":null,"abstract":"Objective: Migraine is a very common,recurring, usually unilateral, severe, pulsating, and transient headache disorder, which causes temporary disability. Migraine has two main types: with aura and without aura. Abnormal retinal and optic disc pathologies in migraine patients were previously reported by using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). In the present study, it was suggested that the changes foundin the retina and optic disc mightindicate a functional disorder in chronic (with and without aura) and episodic (with and without aura) migraine. It is also emphasized that these changes might be useful for early diagnosis and follow-up of the disease, as well as for the development of new treatments. Method: In total, 60 individuals were involved in the present study, including 28 chronic migraine patients (24 female, 4 male, 16 with aura, 12 without aura) and 32 episodic migraine patients (26 female, 6 male, 21 with aura, 11 without aura), who were diagnosed with migraine and whose migraine types were determinedby using the criteria set by the International Headache Society (IHS) in 2013. The control group consisted of 48 healthy volunteers (34 female, 14 male) aged between 18 and 45 years, who applied to the ophthalmology clinic. The retinas and optic discs of the patients were examined by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) at our ophthalmology clinic. A double-blind randomized analysis was performed for the patient data and the data were compared to control group data of similar gender and age groups. Results: Examining the demographic data, no statistically significant difference was found between the migraine patients and the healthy controls in terms of age, gender, migraine history, and migraine type. However, using Optical Coherence Tomography (OCT), it was determined that the mean vertical and horizontal cup-to-disk (c/d) ratios at the optic disc were significantly impaired in patients compared to the control group. Moreover, using Optical Coherence Tomography Angiography (OCTA), significant reductions in vessel density (VD) were detected in the foveal, parafoveal, perifoveal areas and in the superficial and deep capillary plexuses (SCP and DCP) of the patients. Conclusion: It is thought that these findings might be associated with a vasculopathy developing due to a pathology in the autonomic nervous system or impairments in the cerebral, ocular, or systemic circulation. The authors believe that the results achieved in the present study could be useful in the diagnosis, monitoring, and treatment of the disease.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Newly Diagnosed Anaplastic Astrocytoma: > 23 Year Survival in a 31-Year and 11-Month-Old Female Treated with Antineoplastons","authors":"Burzynski Stanislaw, Burzynski Gregory,, Janicki Tomasz, Beenken Samuel","doi":"10.33425/2692-7918.1051","DOIUrl":"https://doi.org/10.33425/2692-7918.1051","url":null,"abstract":"Rationale: Anaplastic astrocytoma (AA), a malignant brain tumor that arises from astrocytic cells, has a poor prognosis. It accounts for 6–7% of gliomas and 1-2% of brain tumors. Objectives: A 31-year and 11-month-old female with an AA is presented to discuss the efficacy of Antineoplastons A10 (Atengenal) and AS2-1 (Astugenal) in the treatment of AA. She presented to the Burzynski Clinic (BC) for treatment and was enrolled in Protocol BT-08, “Phase II Study of Antineoplastons A10 and AS2-1 in Adult Patients with Anaplastic Astrocytoma”, receiving both intravenous (IV) and oral Antineoplastons A10 and AS2-1 (ANP therapy). IV ANP therapy was delivered continuously via subclavian catheter and infusion pump. Tumor response was determined by comparison of baseline brain magnetic resonance imaging (MRI) to sequential brain MRIs during therapy. Findings: The patient presented to the BC with no prior treatment and a one-month history of right arm clumsiness and right leg weakness. Brain MRI and stereotactic biopsy performed elsewhere had demonstrated an AA. Baseline MRI at the BC showed a 2.0 cm2 nonenhancing lesion and two enhancing lesions (0.02 cm2 and 0.15 cm2 ) in the left parietal lobe. IV ANP therapy was given over 56 days, and a complete response (CR) was demonstrated after one month of therapy. Oral ANP therapy was subsequently provided for 17 months. At last follow-up, in June 2023, the patient was healthy and showed no evidence of recurrent disease. She had an overall survival (OS) of > 23 years and one month since diagnosis and an OS of > 23 years since the start of IV ANP therapy. Conclusions: The utilization of ANP therapy in an adult female patient with AA is presented. The patient achieved a CR and prolonged OS, suggesting that ANP therapy may be an effective therapeutic option for adults with AA.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiology of Autism","authors":"Gary Steinman","doi":"10.33425/2692-7918.1049","DOIUrl":"https://doi.org/10.33425/2692-7918.1049","url":null,"abstract":"The causative factor for autism now appears to be a deficient supply of insulin-like growth factor-1 (IGF1 ) and vitamin D3 in many newborn and infants, thereby leading to persistently insufficient myelin in developing cranial nerves. Various malformed neurologic networks last into adulthood. Of particular concern is a pregnancy exposed to febrile viral conditions, where interleukins suppress IGF1 production. Breastfeeding of the newborn may be preventative in many such cases.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curing Classical Homocysteinuria with Pediatric in vitro engineered Liver Organoid Transplantation?","authors":"Stefan Bittmann, Elisabeth Luchter, Lara Bittmann, Elena Moschüring-Alieva, Gloria Villalon","doi":"10.33425/2692-7918.1047","DOIUrl":"https://doi.org/10.33425/2692-7918.1047","url":null,"abstract":"Organoids are groups of cells grown in the laboratory that have self- organized into cell structures resembling those of organs. The term \"organoid\" means \"organ-like.\" In many cases, the cells and cell structures give organoids abilities similar to those of the organs they resemble. Brain organoids, for example, develop layers of nerve cells (neurons) with signaling activity and even \"brain regions\" that resemble areas of the human brain. Currently, organoids created by researchers may bear a strong resemblance to a fully mature organ in certain respects, but crucial differences still exist. Intestinal organoids have a variety of cellular structures that resemble parts of the intestinal mucosa, but are typically the size of a pea and thus not nearly as large or complex as our intestinal tract. But even though they are small, or do not correspond one hundred percent to entire organs, scientists can learn a lot from organoids. Experts believe that organoids represent the \"next generation\" of biological tools for research, drug development and medicine. Liver Organoid engineering could play an important role in treating and curing classic homocysteinuria in childhood by resetting the disturbed function of cystathion beta synthetase activity in the implanted organoid liver. This manuscript focus on liver organoid research to date with special attention to classic homocysteinuria in childhood.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Mirror Neuron System (MNS) in Autism Spectrum Disorders (ASD)","authors":"M. Nabizadeh","doi":"10.33425/2692-7918.1042","DOIUrl":"https://doi.org/10.33425/2692-7918.1042","url":null,"abstract":"The Mirror Neuron System (MNS) is a group of specialized neurons that discharge when an individual performs an action or observes another individual performing the same activity. This system is divided into two principal hubs; the premotor area in the frontal lobe and inferior parietal lobule(IPL). Mirror neurons play an essential role fundamentally in human social interaction, such as action observation, imitation, understanding the emotions of others, and a myriad of other sophisticated human behavior and thought processes as well as the theory of mind. Since people with Autism Spectrum Disorders (ASD) have disorders and defects in communication, social interaction, the theory of mind, etc . So it can be suggested that defects in the mirror neuron system (MNS) may be linked to disorders like ASD and also play an essential role in this phenomenon. In this review, we discuss this connection.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"12 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74566944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External Frontal Sinostomy to Drain Frontal Lobe Abscess","authors":"Sudhir B. Sharma, Gabriel Avalos, Donyale Cappell,, Samridh Sharma","doi":"10.33425/2692-7918.1046","DOIUrl":"https://doi.org/10.33425/2692-7918.1046","url":null,"abstract":"A case of frontal sinusitis with osteomyelitis of its posterior wall producing frontal lobe brain abscess is presented, whereby the posterior wall dehiscence was exposed by external sinostomy by an ENT surgeon and then, through the dehiscence, the abscess was drained by a neurosurgeon. This is an uncommon technique of draining a frontal lobe brain abscess where no frontal bone craniotomy was required. This approach yields the least damage to the cerebral tissue as the frontal abscess was very close to posterior wall of frontal sinus and drain has to travel through minimal intracerebral distance.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"66 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77285269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression in Older Adults - A Review","authors":"Ke Zhou, S. Tan, Shiela P Arroyo, Si Ching Lim","doi":"10.33425/2692-7918.1044","DOIUrl":"https://doi.org/10.33425/2692-7918.1044","url":null,"abstract":"The prevalence of major depressive disorder (MDD) is estimated to be 13.3%, while depressive symptoms are estimated to occur in 28.4% of older adults. A range of medical, functional, and psychosocial risk factors contribute to depression in this population. Depression in older adults may present differently than in younger adults with more physical complaints. Diagnosis becomes even more challenging in the presence of delirium and dementia, which often overlap in an older adult with MDD. It is important to assess suicide risks in older adults with depressive symptoms. Psychotherapy is recommended for mild to moderate depression, while antidepressants should be considered for severe depression or when psychotherapy is not available. Careful monitoring of side effects is important in older adults due to reduced physiological reserves.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"97 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85756691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}