Restorative neurology and neuroscience最新文献

{"title":"The multifaceted effects of flavonoids on neuroplasticity.","authors":"Veronica Rivi, Anuradha Batabyal, Ken Lukowiak","doi":"10.3233/RNN-230150","DOIUrl":"10.3233/RNN-230150","url":null,"abstract":"<p><p>There has been a significant increase in the incidence of multiple neurodegenerative and terminal diseases in the human population with life expectancy increasing in the current times. This highlights the urgent need for a more comprehensive understanding of how different aspects of lifestyle, in particular diet, may affect neural functioning and consequently cognitive performance as well as in enhancing overall health. Flavonoids, found in a variety of fruits, vegetables, and derived beverages, provide a new avenue of research that shows a promising influence on different aspects of brain function. However, despite the promising evidence, most bioactive compounds lack strong clinical research efficacy. In the current scoping review, we highlight the effects of Flavonoids on cognition and neural plasticity across vertebrates and invertebrates with special emphasis on the studies conducted in the pond snail, Lymnaea stagnalis, which has emerged to be a functionally dynamic model for studies on learning and memory. In conclusion, we suggest future research directions and discuss the social, cultural, and ethnic dependencies of bioactive compounds that influence how these compounds are used and accepted globally. Bridging the gap between preclinical and clinical studies about the effects of bioactive natural compounds on brain health will surely lead to lifestyle choices such as dietary Flavonoids being used complementarily rather than as replacements to classical drugs bringing about a healthier future.</p>","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":" ","pages":"93-111"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141601426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 18th World Congress on Controversies in Neurology March 21-23, 2024 - London, UK.","authors":"","doi":"10.3233/RNN-249000","DOIUrl":"https://doi.org/10.3233/RNN-249000","url":null,"abstract":"","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"42 1","pages":"1-90"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychological Aspects and Interventions for Internet Addiction in Adolescents with Asperger's Syndrome - Narrative Review","authors":"Maria Theodoratou, Georgios A. Kougioumtzis, Anna Kaltsouda, Dimitra Katsarou, Zoi Siouti,, Maria Sofologi, George Tsitsas, Katerina Flora","doi":"10.33425/2692-7918.1052","DOIUrl":"https://doi.org/10.33425/2692-7918.1052","url":null,"abstract":"Internet addiction poses a significant concern for adolescents, particularly those diagnosed with Asperger's syndrome. Although empirical research focusing on adolescents with Asperger's syndrome is limited, existing findings reveal several neurocognitive and mental health factors contributing to internet addiction. Impulsivity, attention deficits, social skills deficits, cognitive rigidity, and co-occurring anxiety and depression are among the key aspects identified. Understanding these factors is essential for developing effective interventions. This review discusses neurocognitive and mental health aspects of internet addiction in adolescents with Asperger's syndrome as well as potential interventions targeting these aspects to promote healthy internet use and overall well-being in this unique population.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"38 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136227688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probable Vascular Dementia in the Tropics: A Study of Twenty-Six (26) Observations at Conakry University Hospital","authors":"Barry Souleymane Djigué, Diallo Mohamed Tafsir, Touré Mohamed Lamine, Diallo Souleymane Mbara, Carlos Othon Guelngar, Diallo Bademba, Camara Namory, Sakadi Foksouna, Diallo Mariama Boubacar, Koné Adama, Hinami Madandi, Lamah Eugen, Barry Abdoul Karim Telico, Cissé Fodé Abass, Cissé Amara","doi":"10.33425/2692-7918.1055","DOIUrl":"https://doi.org/10.33425/2692-7918.1055","url":null,"abstract":"Introduction: In tropical environments, the diagnostic certainty of vascular dementia is difficult to establish due to under-medicalization, delays in consultation and above all the inadequacy of exploration methods. Material and methods: We analyzed the records of 153 patients hospitalized for dementia syndrome over a period from January 1, 2016 to December 21, 2021 in the Neurology Department of the Centre Hospitalo-. Universitaire de Conakry. Dementia status was assessed according to the Clinical Evaluation Scale (ECD), Confirmed by Mini Mental State Examination (MMSE<24) cognitive tests or Neuro, behavioral Cognitive Status Examination (NCSE) score. Results: 26 (twenty-six) patients fulfilled the DSM-IV criteria for vascular dementia, based on the association of dementia and cerebrovascular disease certified by the presence of focal neurological signs of vascular origin and imaging data. Conclusion: this study shows a non-stereotyped clinical and etiological profile of the spectrum of vascular dementias in the tropics, in a context of under-medicalization. These results are useful for diagnostic and prognostic discussion.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"38 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136227685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Stroke Mortality in an Urban-Rural Environment: The Case of the MONKOLE Hospital Centre","authors":"Gracia Likinda, Freddy Mbuyi, Gédéon Bukasa, Marc Tshilanda, Rémy Kashala, , Grâce Atibu, Mike Madika, Marina Moanda, Wilfrid Mbombo","doi":"10.33425/2692-7918.1056","DOIUrl":"https://doi.org/10.33425/2692-7918.1056","url":null,"abstract":"Background: Stroke is a fatal disease, and knowledge of the factors associated with this mortality in different environments is necessary in order to take appropriate action. This article presents data from a hospital located in an urban-rural setting in Kinshasa: The Monkole hospital centre. Methods: This is a cross-sectional study conducted at Monkole hospital Centre from 01/01/2020 to 31/01/2023 in all patients with a confirmed diagnosis of stroke admitted to intensive care, emergency or internal medicine. Sociodemographic, clinical, paraclinical, therapeutic and outcome data were collected from hospital registers and patient records. Student's t, Anova, Chi-squared or Fischer's exact tests and logistic regression were performed with SPSS 25.0 with p less than 5%. Ethical principles were respected. Results: Of 3,629 patients admitted during the study period, 148 (4%) were admitted for stroke. The mean age was 62.6 years and the predominant sex was male. 51.4% of patients were admitted from home, with the following comorbidities: arterial hypertension, diabetes mellitus and embolism-induced heart disease. Frequent reasons for consultation were: disturbed consciousness, increased blood pressure and convulsions. Frequent physical signs were: disturbed consciousness, increased blood pressure, neurological deficit and pupillary abnormalities. The average time to hospital was 13.6 ± 8.2 hours. The accident was ischaemic in 70.3% and haemorrhagic in 29.7%. Treatment was medical in 100% of cases, with no thrombolysis. Mortality was 11.5% and 36.5% of survivors had moderate to severe functional disability. Advanced age (OR 2.34, 95% CI 1.36-4.04), hypertension (OR 2.19, 95% CI 1.24-3.88) and low socio-economic status (OR 1.81, 95% CI 1.02-3.21) were associated with mortality. Conclusion: Mortality in this series was 11.5%, associated with advanced age, hypertension and low socioeconomic status. Controlling blood pressure and improving living conditions could reduce this mortality","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"38 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136227690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Network Changes After Exposure to Haptic Vibrotactile Trigger Technology: Results From The ENHANCE Study","authors":"John J Haddad, Mark DeBrincat, Duane M North, Jay Dhaliwal, Peter Hurwitz","doi":"10.33425/2692-7918.1054","DOIUrl":"https://doi.org/10.33425/2692-7918.1054","url":null,"abstract":"The conceptual framework of cognitive networks, or cognits, represents a system of working memory, especially long-term memory arrays that are intrinsically designed to attain certain behavioral ends and that are activated by a neural structure. Despite the fact that cognitions can be used in a plethora of systems, current technologies allow manipulations of the central nervous system (CNS) to execute certain sensory and motor functions. Sensation and tactual perception by the skin are an innate mechanism for human survival and represent our adaptive somatosensorial ability to apprehend information via haptics—the active touch for object recognition and perception by higher centers of the brain. The somatosensation, which is identified by a set of channels and receptors sensitive to a variety of stimuli (thermal, tactile, and mechanical), is critical to survival, balance control, cognition, and pain modulation. Cognits are cutting-edge tools and modalities that provide a landscape of theoretical assets, evidencebased experimental protocols, computational intelligence schemes, and direct empirical modalities that facilitate the understanding of the complex functionalities of the human brain. By evaluating neuroimaging data after somatosensory stimulation and collected via electroencephalogram (EEG), cognition response and change can be obtained that allows researchers to gain a better understanding of emerging scientific approaches aimed at understanding human behavioral outcomes. An emerging technology, haptic vibrotactile trigger technology (VTT), incorporates somatosensory patterns in compression sleeves. eSmartr Smart Compression Sleeves (Srysty Holdings Inc., Mississauga, ON, Canada) with VTT and its Cognitive Boost Technology (CBT) pattern is designed to optimize neural communications for improved mindful wellness. This technology has also been incorporated into patches, braces, apparel (socks), wrist bands, and other routes of delivery. Mindful wellness is considered an outcome of somatosensory intervention that modulates the behavioral responses associated with cognitive networks. Currently, there is limited research exploring these modalities, exposing the need to study new technologies and their influence on somatosensory pathways and cognitive networks. The purpose of this IRB-approved study was to explore the effects of forearm VTT stimulation patterns on cognitive networks by comparing a baseline EEG to an EEG after placing a sleeve incorporating VTT on the right or left forearm of adult healthy individuals. Materials and methods: A baseline EEG was recorded over 5 minutes from 19 scalp locations on 20 subjects ranging in age from 17.6 years to 41.9 years (n=7 females, 13 males). The subject’s dominant arm was then fitted with the eSmartr Smart Compression Sleeve for 20 minutes and another 5-minute EEG was recorded. Both the LORETA (Low Resolution Electromagnetic Tomography Analysis) inverse solution and a power spectral analysis of t","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"37 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136227696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Shadow Psyche in Leadership &amp; Decision- Making: A Praxeology Perspective on the Collective Unconscious Psyche","authors":"Rose-Marie Boylan","doi":"10.33425/2692-7918.1053","DOIUrl":"https://doi.org/10.33425/2692-7918.1053","url":null,"abstract":"","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"38 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136227692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Compression Severity and Hand Dexterity, Sleep, Quality of Life, Neuropathic Pain, and Anxiety-Depression in Patients with Carpal and Cubital Tunnel Syndrome","authors":"Buket Özkara Yılmaz","doi":"10.33425/2692-7918.1050","DOIUrl":"https://doi.org/10.33425/2692-7918.1050","url":null,"abstract":"Objective: Carpal and cubital tunnel syndromes are common entrapment neuropathies [1]. Some previous studies showed that carpal tunnel syndrome and, to a lesser extent, cubital tunnel syndrome can impair sleep and quality of life [2-4]. But there are only few studies comparing these two syndromes [5]. However, no study, which evaluates hand dexterity, sleep quality, quality of life, and neuropathic pain in relation to the severity of compression determined by Electroneurography (ENMG) in both syndromes, could be found in the literature. Thus, it was aimed in the present study to investigate the relationship between hand dexterity, sleep quality, quality of life, neuropathic pain, and anxiety-depression symptoms with different levels of compression severity in patients clinically and electro-physiologically diagnosed with carpal tunnel syndrome and cubital tunnel syndrome. Materials and methods: This study involved patients, who applied to the ENMG laboratory and were18 years or older and clinically and electro-physiologically diagnosed with carpal tunnel syndrome and cubital tunnel syndrome. The sociodemographic and clinical data of the patients who agreed to participate in the study were recorded. Carpal tunnel syndrome was classified as mild, moderate, and severe by using the American Association of Electrodiagnostic Medicine Classification [12] based on electrophysiological data, whereas the classification of cubital tunnel syndrome was performed by using the electrodiagnostic grading system created by Zeidman and Pandey based on the American Association of Electrodiagnostic Medicine practice guidelines [13]. The Pittsburgh Sleep Quality Index [14,15] and Epworth Sleepiness Scale [16,17] were used in evaluating the sleep quality of the patients, the EuroQuol-5D Quality of Life Scale [18,19] for quality of life, the 4-item neuropathic pain scale [20,21] for neuropathic pain, the Hospital Anxiety and Depression Scale [22,23] for anxiety and depression levels, and the 9-Hole Peg Test [24] for hand dexterity. After the forms were filled in, the data of the patients having carpal tunnel syndrome and those of patients having cubital tunnel syndrome were compared statistically. Moreover, after staging them as mild, moderate, and severe, the findings of patients in both groups were compared within each group, and their relationships were investigated. Results: Sleep disorders, neuropathic pain, depression, and anxiety disorders were observed to be much more prevalent among patients with CTS when compared to the patients with CuTS and the severity of these disorders increases together with an increase in the severity of the disease. It was also determined that CTS patients lag behind CuTS patients in fine motor skills. Conclusion: It should be noted that all of these parameters negatively affect the quality of life of patients. Early physiotherapy and rehabilitation can be beneficial in the treatment of patients and can contribute to their quality of l","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Retina and Optic Discs of Patients with Chronic and Episodic Migraine using Optical Coherence Tomography and Optical Coherence Tomography Angiography","authors":"Buket Yılmaz,, Ali Karnaz","doi":"10.33425/2692-7918.1048","DOIUrl":"https://doi.org/10.33425/2692-7918.1048","url":null,"abstract":"Objective: Migraine is a very common,recurring, usually unilateral, severe, pulsating, and transient headache disorder, which causes temporary disability. Migraine has two main types: with aura and without aura. Abnormal retinal and optic disc pathologies in migraine patients were previously reported by using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). In the present study, it was suggested that the changes foundin the retina and optic disc mightindicate a functional disorder in chronic (with and without aura) and episodic (with and without aura) migraine. It is also emphasized that these changes might be useful for early diagnosis and follow-up of the disease, as well as for the development of new treatments. Method: In total, 60 individuals were involved in the present study, including 28 chronic migraine patients (24 female, 4 male, 16 with aura, 12 without aura) and 32 episodic migraine patients (26 female, 6 male, 21 with aura, 11 without aura), who were diagnosed with migraine and whose migraine types were determinedby using the criteria set by the International Headache Society (IHS) in 2013. The control group consisted of 48 healthy volunteers (34 female, 14 male) aged between 18 and 45 years, who applied to the ophthalmology clinic. The retinas and optic discs of the patients were examined by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) at our ophthalmology clinic. A double-blind randomized analysis was performed for the patient data and the data were compared to control group data of similar gender and age groups. Results: Examining the demographic data, no statistically significant difference was found between the migraine patients and the healthy controls in terms of age, gender, migraine history, and migraine type. However, using Optical Coherence Tomography (OCT), it was determined that the mean vertical and horizontal cup-to-disk (c/d) ratios at the optic disc were significantly impaired in patients compared to the control group. Moreover, using Optical Coherence Tomography Angiography (OCTA), significant reductions in vessel density (VD) were detected in the foveal, parafoveal, perifoveal areas and in the superficial and deep capillary plexuses (SCP and DCP) of the patients. Conclusion: It is thought that these findings might be associated with a vasculopathy developing due to a pathology in the autonomic nervous system or impairments in the cerebral, ocular, or systemic circulation. The authors believe that the results achieved in the present study could be useful in the diagnosis, monitoring, and treatment of the disease.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Newly Diagnosed Anaplastic Astrocytoma: &gt; 23 Year Survival in a 31-Year and 11-Month-Old Female Treated with Antineoplastons","authors":"Burzynski Stanislaw, Burzynski Gregory,, Janicki Tomasz, Beenken Samuel","doi":"10.33425/2692-7918.1051","DOIUrl":"https://doi.org/10.33425/2692-7918.1051","url":null,"abstract":"Rationale: Anaplastic astrocytoma (AA), a malignant brain tumor that arises from astrocytic cells, has a poor prognosis. It accounts for 6–7% of gliomas and 1-2% of brain tumors. Objectives: A 31-year and 11-month-old female with an AA is presented to discuss the efficacy of Antineoplastons A10 (Atengenal) and AS2-1 (Astugenal) in the treatment of AA. She presented to the Burzynski Clinic (BC) for treatment and was enrolled in Protocol BT-08, “Phase II Study of Antineoplastons A10 and AS2-1 in Adult Patients with Anaplastic Astrocytoma”, receiving both intravenous (IV) and oral Antineoplastons A10 and AS2-1 (ANP therapy). IV ANP therapy was delivered continuously via subclavian catheter and infusion pump. Tumor response was determined by comparison of baseline brain magnetic resonance imaging (MRI) to sequential brain MRIs during therapy. Findings: The patient presented to the BC with no prior treatment and a one-month history of right arm clumsiness and right leg weakness. Brain MRI and stereotactic biopsy performed elsewhere had demonstrated an AA. Baseline MRI at the BC showed a 2.0 cm2 nonenhancing lesion and two enhancing lesions (0.02 cm2 and 0.15 cm2 ) in the left parietal lobe. IV ANP therapy was given over 56 days, and a complete response (CR) was demonstrated after one month of therapy. Oral ANP therapy was subsequently provided for 17 months. At last follow-up, in June 2023, the patient was healthy and showed no evidence of recurrent disease. She had an overall survival (OS) of &gt; 23 years and one month since diagnosis and an OS of &gt; 23 years since the start of IV ANP therapy. Conclusions: The utilization of ANP therapy in an adult female patient with AA is presented. The patient achieved a CR and prolonged OS, suggesting that ANP therapy may be an effective therapeutic option for adults with AA.","PeriodicalId":21130,"journal":{"name":"Restorative neurology and neuroscience","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136276619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}