Jordan N Williamson, Shirley A James, Beni Mulyana, Sally Kim, Dorothy He, Sheng Li, Evgeny V Sidorov, Yuan Yang
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引用次数: 0
Abstract
High-definition transcranial direct current stimulation (HD-tDCS) is a promising approach for stroke rehabilitation, which may induce functional changes in the cortical sensorimotor areas to facilitate movement recovery. However, it lacks an objective measure that can indicate the effect of HD-tDCS on alteration of brain activity. Quantitative electroencephalography (qEEG) has shown promising results as an indicator of post-stroke functional recovery. Therefore, this study aims to determine whether qEEG metrics could serve as quantitative measures to assess alteration in brain activity induced by HD-tDCS. Resting state EEG was collected from stroke participants before and after (1) anodal HD-tDCS of the lesioned hemisphere, (2) cathodal stimulation of the non-lesioned hemisphere, and (3) sham. The average power spectrum was calculated using the Fast Fourier Transform for frequency bands alpha, beta, delta, and theta. In addition, delta-alpha ratio (DAR), Delta-alpha-beta-theta ratio (DTABR), and directional brain symmetry index (BSI) were also evaluated. We found that both anodal and cathodal stimulation significantly decreased the DAR and BSI over various frequency bands, which are associated with reduced motor impairments and improved nerve conduction velocity from the brain to muscles. This result indicates that qEEG metrics DAR and BSI could be quantitative indicators to assess alteration of brain activity induced by HD-tDCS in stroke rehabilitation. This would allow future development of EEG-based neurofeedback system to guide and evaluate the effect of HD-tDCS on improving movement-related brain function in stroke.
期刊介绍：
This interdisciplinary journal publishes papers relating to the plasticity and response of the nervous system to accidental or experimental injuries and their interventions, transplantation, neurodegenerative disorders and experimental strategies to improve regeneration or functional recovery and rehabilitation. Experimental and clinical research papers adopting fresh conceptual approaches are encouraged. The overriding criteria for publication are novelty, significant experimental or clinical relevance and interest to a multidisciplinary audience. Experiments on un-anesthetized animals should conform with the standards for the use of laboratory animals as established by the Institute of Laboratory Animal Resources, US National Academy of Sciences. Experiments in which paralytic agents are used must be justified. Patient identity should be concealed. All manuscripts are sent out for blind peer review to editorial board members or outside reviewers. Restorative Neurology and Neuroscience is a member of Neuroscience Peer Review Consortium.
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