RespirologyPub Date : 2024-09-03DOI: 10.1111/resp.14820
Joshua A Bishop, Lissa M Spencer, Tiffany J Dwyer, Zoe J McKeough, Amanda McAnulty, Regina Leung, Jennifer A Alison
{"title":"Effect of pulmonary rehabilitation duration on exercise capacity and health-related quality of life in people with chronic obstructive pulmonary disease (PuRe Duration Trial): A randomized controlled equivalence trial.","authors":"Joshua A Bishop, Lissa M Spencer, Tiffany J Dwyer, Zoe J McKeough, Amanda McAnulty, Regina Leung, Jennifer A Alison","doi":"10.1111/resp.14820","DOIUrl":"https://doi.org/10.1111/resp.14820","url":null,"abstract":"<p><strong>Background and objective: </strong>There is no strong evidence on the optimal duration of pulmonary rehabilitation (PR) programmes. The aim of the study was to determine whether an 8-week PR programme was equivalent to a 12-week PR programme in improving endurance exercise capacity in people with chronic obstructive pulmonary disease (COPD).</p><p><strong>Methods: </strong>Participants with COPD were randomized to either an 8-week (8-wk Group) or 12-week (12-wk Group), twice weekly, supervised PR programme consisting of endurance and strength training and individualized self-management education. Between group comparisons were made at completion of each programme (i.e., week 8 or week 12), for both programmes at week 12, and at 6-12-month follow-up. The primary outcome was endurance exercise capacity measured by the endurance shuttle walk test (ESWT) with the minimally important difference of 186 s set as the equivalence limit.</p><p><strong>Results: </strong>Sixty-six participants [mean (SD); age 69 (7) years, FEV<sub>1</sub> 48 (17) %predicted] were randomized (33 per group). Between-group comparisons demonstrated that the ESWT time was equivalent for the 12-wk Group compared to the 8-wk Group at programme completion [mean (95% CI)] [71 s (-61 to 203)], week 12 [70 s (-68 to 208)], and 6-12-month follow-up [93 s (-52 to 239)], though superiority of the 12-wk Group could not be ruled out at each time point.</p><p><strong>Conclusion: </strong>Equivalence was shown between 8-and 12-week PR programmes for endurance exercise capacity, but superiority could not be ruled out for the 12-wk Group. Decisions about programme duration may depend on local waitlist times, healthcare budgets and patient preference.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-09-01Epub Date: 2024-06-10DOI: 10.1111/resp.14768
Fraser Brims
{"title":"Lung cancer and lymphangioleiomyomatosis: A common complication in an uncommon condition.","authors":"Fraser Brims","doi":"10.1111/resp.14768","DOIUrl":"10.1111/resp.14768","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"751-752"},"PeriodicalIF":6.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141301516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypoxic indices for obstructive sleep apnoea severity and cardiovascular disease risk prediction: A comparison and application in a community population.","authors":"Xinjie Hui, Wenhao Cao, Zeyu Xu, Junwei Guo, Jinmei Luo, Yi Xiao","doi":"10.1111/resp.14754","DOIUrl":"10.1111/resp.14754","url":null,"abstract":"<p><strong>Background and objective: </strong>The apnoea-hypopnoea index (AHI) and oxygen desaturation index (ODI) encounter challenges in capturing the intricate relationship between obstructive sleep apnoea (OSA) and cardiovascular disease (CVD) risks. Although novel hypoxic indices have been proposed to tackle these limitations, there remains a gap in comprehensive validation and comparisons across a unified dataset.</p><p><strong>Methods: </strong>Samples were derived from the Sleep Heart Health Study (SHHS), involving 4485 participants aged over 40 years after data quality screening. The study compared several key indices, including AHI, ODI, the reconstructed hypoxic burden (rHB), the percentage of sleep time with the duration of respiratory events causing desaturation (pRED_3p) and the sleep breathing impairment index (SBII), in relation to CVD mortality and morbidity risks. Adjusted Cox proportional models were employed to calculate hazard ratios (HRs) for each index, and comparisons were performed.</p><p><strong>Results: </strong>SBII and pRED_3p exhibited significant correlations with both CVD mortality and morbidity, with SBII showing the highest adjusted HR (95% confidence interval) for mortality (2.04 [1.25, 3.34]) and pRED_3p for morbidity (1.43 [1.09-1.88]). In contrast, rHB was only significant in predicting CVD mortality (1.63 [1.05-2.53]), while AHI and ODI did not show significant correlations with CVD outcomes. The adjusted models based on SBII and pRED_3p exhibited optimal performance in the CVD mortality and morbidity datasets, respectively.</p><p><strong>Conclusion: </strong>This study identified the optimal indices for OSA-related CVD risks prediction, SBII for mortality and pRED_3p for morbidity. The open-source online platform provides the computation of the indices.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"825-834"},"PeriodicalIF":6.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141076637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-09-01Epub Date: 2024-07-15DOI: 10.1111/resp.14794
Richard D Branson
{"title":"Home oxygen guidelines: We do not know enough about LTOT.","authors":"Richard D Branson","doi":"10.1111/resp.14794","DOIUrl":"10.1111/resp.14794","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"741-742"},"PeriodicalIF":6.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-09-01Epub Date: 2024-07-08DOI: 10.1111/resp.14786
Inès Van Rossem, Shane Hanon, Johan Vansintejan, Sylvia Verbanck, Eef Vanderhelst
{"title":"Is fractional exhaled nitric oxide ready to be a biomarker? Within-day variability in stable COPD.","authors":"Inès Van Rossem, Shane Hanon, Johan Vansintejan, Sylvia Verbanck, Eef Vanderhelst","doi":"10.1111/resp.14786","DOIUrl":"10.1111/resp.14786","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"835-837"},"PeriodicalIF":6.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-09-01Epub Date: 2024-07-25DOI: 10.1111/resp.14802
Van K Holden, Ashutosh Sachdeva
{"title":"Timely stenting in malignant central airway obstruction: Timely guidelines and time for multidisciplinary care.","authors":"Van K Holden, Ashutosh Sachdeva","doi":"10.1111/resp.14802","DOIUrl":"10.1111/resp.14802","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"745-746"},"PeriodicalIF":6.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-09-01Epub Date: 2024-05-27DOI: 10.1111/resp.14755
Ryan F Hoy, Catherine Jones, Katrina Newbigin, Michael J Abramson, Hayley Barnes, Christina Dimitriadis, Samantha Ellis, Deborah C Glass, Stella M Gwini, Fiona Hore-Lacy, Javier Jimenez-Martin, Sundeep S Pasricha, Janu Pirakalathanan, Miranda Siemienowicz, Karen Walker-Bone, Malcolm R Sim
{"title":"Chest x-ray has low sensitivity to detect silicosis in artificial stone benchtop industry workers.","authors":"Ryan F Hoy, Catherine Jones, Katrina Newbigin, Michael J Abramson, Hayley Barnes, Christina Dimitriadis, Samantha Ellis, Deborah C Glass, Stella M Gwini, Fiona Hore-Lacy, Javier Jimenez-Martin, Sundeep S Pasricha, Janu Pirakalathanan, Miranda Siemienowicz, Karen Walker-Bone, Malcolm R Sim","doi":"10.1111/resp.14755","DOIUrl":"10.1111/resp.14755","url":null,"abstract":"<p><strong>Background and objective: </strong>Chest x-ray (CXR) remains a core component of health monitoring guidelines for workers at risk of exposure to crystalline silica. There has however been a lack of evidence regarding the sensitivity of CXR to detect silicosis in artificial stone benchtop industry workers.</p><p><strong>Methods: </strong>Paired CXR and high-resolution computed tomography (HRCT) images were acquired from 110 artificial stone benchtop industry workers. Blinded to the clinical diagnosis, each CXR and HRCT was independently read by two thoracic radiologists from a panel of seven, in accordance with International Labour Office (ILO) methodology for CXR and International Classification of HRCT for Occupational and Environmental Respiratory Diseases. Accuracy of screening positive (ILO major category 1, 2 or 3) and negative (ILO major category 0) CXRs were compared with identification of radiological features of silicosis on HRCT.</p><p><strong>Results: </strong>CXR was positive for silicosis in 27/110 (24.5%) workers and HRCT in 40/110 (36.4%). Of the 83 with a negative CXR (ILO category 0), 15 (18.1%) had silicosis on HRCT. All 11 workers with ILO category 2 or 3 CXRs had silicosis on HRCT. In 99 workers ILO category 0 or 1 CXRs, the sensitivity of screening positive CXR compared to silicosis identified by HRCT was 48% (95%CI 29-68) and specificity 97% (90-100).</p><p><strong>Conclusion: </strong>Compared to HRCT, sensitivity of CXR was low but specificity was high. Reliance on CXR for health monitoring would provide false reassurance for many workers, delay management and underestimate the prevalence of silicosis in the artificial stone benchtop industry.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"785-794"},"PeriodicalIF":6.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}