Respirology最新文献

筛选
英文 中文
Leading Women in Respiratory Clinical Sciences: Letter From New Zealand. 呼吸临床科学的领军女性:来自新西兰的信。
IF 6.6 2区 医学
Respirology Pub Date : 2025-03-01 Epub Date: 2025-02-16 DOI: 10.1111/resp.70006
Betty Poot
{"title":"Leading Women in Respiratory Clinical Sciences: Letter From New Zealand.","authors":"Betty Poot","doi":"10.1111/resp.70006","DOIUrl":"10.1111/resp.70006","url":null,"abstract":"<p><p>Special Series: Leading Women in Respiratory Clinical Sciences. Series Editors: Anne-Marie Russell and Kathleen O Lindell See related editorial.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"264-266"},"PeriodicalIF":6.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lifetime Body Mass Index Trajectories and Contrasting Lung Function Abnormalities in Mid-Adulthood: Data From the Tasmanian Longitudinal Health Study. 成年中期终生体重指数轨迹和对比肺功能异常:来自塔斯马尼亚纵向健康研究的数据。
IF 6.6 2区 医学
Respirology Pub Date : 2025-03-01 Epub Date: 2025-01-26 DOI: 10.1111/resp.14882
Gulshan B Ali, Adrian J Lowe, E Haydn Walters, Jennifer L Perret, Bircan Erbas, Caroline J Lodge, Gayan Bowatte, Paul S Thomas, Garun S Hamilton, Bruce R Thompson, David P Johns, John L Hopper, Michael J Abramson, Dinh S Bui, Shyamali C Dharmage
{"title":"Lifetime Body Mass Index Trajectories and Contrasting Lung Function Abnormalities in Mid-Adulthood: Data From the Tasmanian Longitudinal Health Study.","authors":"Gulshan B Ali, Adrian J Lowe, E Haydn Walters, Jennifer L Perret, Bircan Erbas, Caroline J Lodge, Gayan Bowatte, Paul S Thomas, Garun S Hamilton, Bruce R Thompson, David P Johns, John L Hopper, Michael J Abramson, Dinh S Bui, Shyamali C Dharmage","doi":"10.1111/resp.14882","DOIUrl":"10.1111/resp.14882","url":null,"abstract":"<p><strong>Background and objective: </strong>The impact of lifetime body mass index (BMI) trajectories on adult lung function abnormalities has not been investigated previously. We investigated associations of BMI trajectories from childhood to mid-adulthood with lung function deficits and COPD in mid-adulthood.</p><p><strong>Methods: </strong>Five BMI trajectories (n = 4194) from age 5 to 43 were identified in the Tasmanian Longitudinal Health Study. Lung function outcomes were defined using spirometry at 45 and 53 years. Associations between these BMI trajectories and lung function outcomes were investigated using multivariable regression.</p><p><strong>Results: </strong>Compared to the average BMI trajectory, the child's average-increasing BMI trajectory was associated with greater FVC decline from 45 to 53 years (β = -178 mL; 95% CI -300.6, -55.4), lower FRC, ERV and higher TLco at 45 years, lower FVC (-227 mL; -345.3, -109.1) and higher TLco at 53 years. The High BMI trajectory was also associated with lower FRC, ERV and higher TLco at 45 years, while spirometric restriction (OR = 6.9; 2.3, 21.1) and higher TLco at 53 years. The low BMI trajectory was associated with an obstructive picture: lower FEV<sub>1</sub> (-124 mL; -196.4, -51.4) and FVC (-91 mL; -173.4, -7.7), and FEV<sub>1</sub>/FVC (-1.2%; -2.2, -0.1) and higher ERV and lower TLco at 45 and 53 years. A similar pattern was found at 53 years. No associations were observed with spirometrically defined COPD.</p><p><strong>Conclusion: </strong>Our findings revealed contrasting lung function abnormalities were associated with high, subsequently increasing, and low BMI trajectories. These results emphasise the importance of tracking changes in BMI over time and the need to maintain an average BMI trajectory (BMI-Z-score 0 at each time point) throughout life.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"230-241"},"PeriodicalIF":6.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Overlap of Cardiac and Respiratory Disease. 心脏和呼吸系统疾病的重叠。
IF 6.6 2区 医学
Respirology Pub Date : 2025-03-01 Epub Date: 2025-01-19 DOI: 10.1111/resp.14878
Charles Feldman
{"title":"The Overlap of Cardiac and Respiratory Disease.","authors":"Charles Feldman","doi":"10.1111/resp.14878","DOIUrl":"10.1111/resp.14878","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"192-195"},"PeriodicalIF":6.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fly Me to the Moon (or Not). 飞向月球(或不飞)。
IF 6.6 2区 医学
Respirology Pub Date : 2025-03-01 Epub Date: 2025-01-27 DOI: 10.1111/resp.14886
Natasha Smallwood
{"title":"Fly Me to the Moon (or Not).","authors":"Natasha Smallwood","doi":"10.1111/resp.14886","DOIUrl":"10.1111/resp.14886","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"262-263"},"PeriodicalIF":6.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sputum metagenomics reveals a multidrug resistant Pseudomonas-dominant severe asthma phenotype in an Asian population. 痰元基因组学揭示了亚洲人群中以假单胞菌为主的多重耐药严重哮喘表型。
IF 6.6 2区 医学
Respirology Pub Date : 2025-03-01 Epub Date: 2024-12-02 DOI: 10.1111/resp.14863
Fransiskus Xaverius Ivan, Pei Yee Tiew, Tavleen Kaur Jaggi, Kai Xian Thng, Pee Hwee Pang, Thun How Ong, John Arputhan Abisheganaden, Mariko Siyue Koh, Sanjay H Chotirmall
{"title":"Sputum metagenomics reveals a multidrug resistant Pseudomonas-dominant severe asthma phenotype in an Asian population.","authors":"Fransiskus Xaverius Ivan, Pei Yee Tiew, Tavleen Kaur Jaggi, Kai Xian Thng, Pee Hwee Pang, Thun How Ong, John Arputhan Abisheganaden, Mariko Siyue Koh, Sanjay H Chotirmall","doi":"10.1111/resp.14863","DOIUrl":"10.1111/resp.14863","url":null,"abstract":"<p><strong>Background and objective: </strong>While the lung microbiome in severe asthma has been studied, work has employed targeted amplicon-based sequencing approaches without functional assessment with none focused on multi-ethnic Asian populations. Here we investigate the clinical relevance of microbial phenotypes of severe asthma in Asians using metagenomics.</p><p><strong>Methods: </strong>Prospective assessment of clinical, radiological, and immunological measures were performed in a multi-ethnic Asian severe asthma cohort (N = 70) recruited across two centres in Singapore. Sputum was subjected to shotgun metagenomic sequencing and patients followed up for a 2-year period. Metagenomic assessment of sputum microbiomes, resistomes and virulomes were related to clinical outcomes.</p><p><strong>Results: </strong>The lung microbiome in a multi-ethnic Asian cohort with severe asthma demonstrates an increased abundance of Pseudomonas species. Unsupervised clustering of sputum metagenomes identified two patient clusters: C1 (n = 52) characterized by upper airway commensals and C2 (n = 18) dominated by established respiratory pathogens including M. catarrhalis, S. aureus and most significantly P. aeruginosa. C2 patients demonstrated a significantly increased exacerbation frequency on 2-year follow up and an antimicrobial resistome characterized by multidrug resistance. Virulomes appear indistinguishable between severe asthmatics with or without co-existing bronchiectasis, and C2 patients exhibit increased gene expression related to biofilm formation, effector delivery systems and microbial motility. Independent comparison of the C2 cluster to a non-asthmatic bronchiectasis cohort demonstrates analogous airway microbial virulence patterns.</p><p><strong>Conclusion: </strong>Sputum metagenomics demonstrates a multidrug-resistant Pseudomonas-dominant severe asthma phenotype in Asians, characterized by poor clinical outcome including increased exacerbations which is independent of co-existing bronchiectasis.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"217-229"},"PeriodicalIF":6.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sputum Metagenomics Reveals Multidrug-Resistant Pseudomonas-Dominant Communities in Severe Asthma. 痰元基因组学揭示严重哮喘患者多药耐药假单胞菌优势群落。
IF 6.6 2区 医学
Respirology Pub Date : 2025-03-01 Epub Date: 2025-02-02 DOI: 10.1111/resp.14890
Sara K Di Simone, Samuel C Forster
{"title":"Sputum Metagenomics Reveals Multidrug-Resistant Pseudomonas-Dominant Communities in Severe Asthma.","authors":"Sara K Di Simone, Samuel C Forster","doi":"10.1111/resp.14890","DOIUrl":"10.1111/resp.14890","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"186-187"},"PeriodicalIF":6.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thoracic Society of Australia and New Zealand (TSANZ) Is Abrogating Its Leadership Role in Asia-Pacific. 澳大利亚和新西兰胸科学会(TSANZ)正在放弃其在亚太地区的领导作用。
IF 6.6 2区 医学
Respirology Pub Date : 2025-03-01 Epub Date: 2025-01-21 DOI: 10.1111/resp.14884
Philip Bardin, Christine McDonald, Debra Sandford, Gregory King, Christine Jenkins, Paul Reynolds
{"title":"Thoracic Society of Australia and New Zealand (TSANZ) Is Abrogating Its Leadership Role in Asia-Pacific.","authors":"Philip Bardin, Christine McDonald, Debra Sandford, Gregory King, Christine Jenkins, Paul Reynolds","doi":"10.1111/resp.14884","DOIUrl":"10.1111/resp.14884","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"190-191"},"PeriodicalIF":6.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuberculosis: An Update for the Clinician. 结核病:临床医生的最新进展。
IF 6.6 2区 医学
Respirology Pub Date : 2025-03-01 Epub Date: 2025-01-31 DOI: 10.1111/resp.14887
Saskia Janssen, Melissa Murphy, Caryn Upton, Brian Allwood, Andreas H Diacon
{"title":"Tuberculosis: An Update for the Clinician.","authors":"Saskia Janssen, Melissa Murphy, Caryn Upton, Brian Allwood, Andreas H Diacon","doi":"10.1111/resp.14887","DOIUrl":"10.1111/resp.14887","url":null,"abstract":"<p><p>Tuberculosis (TB) remains a significant global health threat with high mortality and efforts to meet WHO End TB Strategy milestones are off-track. It has become clear that TB is not a dichotomous infection with latent and active forms but presents along a disease spectrum. Subclinical TB plays a larger role in transmission than previously thought. Aerosol studies have shown that undiagnosed TB patients, even with paucibacillary disease, can be highly infectious and significantly contribute to TB spread. Encouraging clinical results have been seen with the M72/AS01<sub>E</sub> vaccine. If preliminary results can be confirmed in ongoing larger trials, modelling shows the vaccine can positively impact the epidemic. TB preventive therapy (TPT), especially for high-risk groups like people living with HIV and household contacts of drug-resistant TB patients, has shown efficacy but implementation is resource intensive. Treatment options for infectious patients have grown rapidly. New shorter, all-oral treatment regimens represent a breakthrough, but progress is threatened by rising resistance to bedaquiline. Many new chemical entities are entering clinical trials and raise hopes for all-new regimens that could overcome rising resistance rates to conventional agents. More research is needed on the management of complex cases, such as central nervous system TB and severe HIV-associated TB. Post-TB lung disease (PTLD) is an under-recognised but growing concern, affecting millions of survivors with lasting respiratory impairment and increased mortality. Continued investment in development of TB vaccines and therapeutics, treatment shortening, and management of TB sequelae is critical to combat this ongoing public health challenge.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"196-205"},"PeriodicalIF":6.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A digital therapy targeting anxiety in pulmonary fibrosis: A decentralized randomized controlled trial. 针对肺纤维化患者焦虑的数字疗法:一项分散的随机对照试验。
IF 6.6 2区 医学
Respirology Pub Date : 2025-03-01 Epub Date: 2024-12-03 DOI: 10.1111/resp.14859
Joshua J Solomon, Robert W Hallowell, Cecilia Ganslandt, Jessica G Shull, Thomas Bengtsson, Jakob Ganslandt, Maureen R Horton
{"title":"A digital therapy targeting anxiety in pulmonary fibrosis: A decentralized randomized controlled trial.","authors":"Joshua J Solomon, Robert W Hallowell, Cecilia Ganslandt, Jessica G Shull, Thomas Bengtsson, Jakob Ganslandt, Maureen R Horton","doi":"10.1111/resp.14859","DOIUrl":"10.1111/resp.14859","url":null,"abstract":"<p><strong>Background and objective: </strong>Pulmonary fibrosis, a manifestation of interstitial lung disease, is frequently associated with anxiety. The objective of this study, COMPANION, was to assess the anxiolytic efficacy of Almee, a digital cognitive behavioural therapy for patients with pulmonary fibrosis, compared to treatment as usual.</p><p><strong>Methods: </strong>COMPANION was a randomized, controlled, open-label and partly reader-blinded, decentralized, clinical trial conducted in the United States. Eligible patients had radiology-confirmed pulmonary fibrosis and a Generalized Anxiety Disorder 7-item (GAD-7) score of ≥5 (possible range 0-21). Participants were randomized 1:1 to Almee or no intervention for 9 weeks, with block stratification by anxiety severity. The primary endpoint was change in GAD-7 score from baseline to week 9. Between 20 December 2022 and 14 August 2023, 108 participants were randomized, 54 to Almee and 54 to treatment as usual.</p><p><strong>Results: </strong>In each arm, 46 participants completed the study; 108 cases were analysed as intention-to-treat. By week 9, average GAD-7 score had improved by 1.8 points (SEM = 2.1) in the Almee group (n = 54) and deteriorated by 0.9 points (SEM = 2.2) in the control group (n = 54), a 2.7-point difference (95% confidence interval: 1.2-4.2, p = 0.0006).</p><p><strong>Conclusion: </strong>Treatment with Almee was well-tolerated and showed clinically meaningful improvement in pulmonary fibrosis-related anxiety. Almee shows promise as a personalized intervention for management of the psychological burden related to living with pulmonary fibrosis.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"253-261"},"PeriodicalIF":6.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Validation of a Risk Prediction Model to Identify Women With Chronic Obstructive Pulmonary Disease for Proactive Palliative Care. 慢性阻塞性肺疾病女性患者主动姑息治疗风险预测模型的建立与验证
IF 6.6 2区 医学
Respirology Pub Date : 2025-02-16 DOI: 10.1111/resp.70005
Begashaw Melaku Gebresillassie, John Attia, Dominic Cavenagh, Melissa L Harris
{"title":"Development and Validation of a Risk Prediction Model to Identify Women With Chronic Obstructive Pulmonary Disease for Proactive Palliative Care.","authors":"Begashaw Melaku Gebresillassie, John Attia, Dominic Cavenagh, Melissa L Harris","doi":"10.1111/resp.70005","DOIUrl":"https://doi.org/10.1111/resp.70005","url":null,"abstract":"<p><strong>Background and objective: </strong>Proactive palliative interventions can improve symptom control and quality of life in individuals with chronic obstructive pulmonary disease (COPD); however, they are often underutilised. This study aimed to develop and validate a prediction model to identify women with COPD in their last year of life to facilitate timely palliative care referrals and interventions.</p><p><strong>Methods: </strong>Data from 1236 women diagnosed with COPD from the 1921-1926 Australian Longitudinal Study on Women's Health cohort, linked to administrative health records, were analysed. We employed Lasso regression and multivariable logistic regression to select predictors. To assess the predictive performance of the model, we used the area under the receiver operating characteristic (AUROC) curve, calibration plot, and calibration metrics. The Youden index was used to establish the optimal cutoff point for risk classification. The clinical utility of the model was evaluated using decision curve analysis (DCA).</p><p><strong>Results: </strong>The final model to predict 1-year all-cause mortality included six predictors: smoking status, body mass index, needing regular assistance with daily activities, number of supplied medications, duration of illness, and number of hospital admissions. The model performed well, with AUROC of 0.82 (95% CI: 0.80-0.85) and showed excellent calibration. Using a cutoff of 56.6% predicted risk, the model achieved a sensitivity of 72.3%, specificity of 77.7%, and accuracy of 75.0%. The DCA indicated that the model provided a greater net benefit for clinical decision-making.</p><p><strong>Conclusion: </strong>Our prediction model for identifying women with COPD who may benefit from palliative care has shown robust predictive performance and can be easily applied, but requires external validation.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信