IF 6.6 2区医学

Respirology Pub Date : 2024-12-17 DOI: 10.1111/resp.14874

Laura M Glenn, Dan Jackson, Carly Barton, Doris Lan, Lisa Fuhrmeister, Karen Symons, Louise Turnour, Ben Tefay, Anne E Holland, Nicole S L Goh, Lauren K Troy, Mark Brooke, Ian N Glaspole, Tamera J Corte

{"title":"Usability of a smartphone application for patients with interstitial lung disease: Results from the Registry for Better Understanding of ILD (RE-BUILD) pilot study.","authors":"Laura M Glenn, Dan Jackson, Carly Barton, Doris Lan, Lisa Fuhrmeister, Karen Symons, Louise Turnour, Ben Tefay, Anne E Holland, Nicole S L Goh, Lauren K Troy, Mark Brooke, Ian N Glaspole, Tamera J Corte","doi":"10.1111/resp.14874","DOIUrl":"https://doi.org/10.1111/resp.14874","url":null,"abstract":"Background and objective: Digital technologies offer opportunities for remote monitoring, increased patient engagement and incorporation of patient-reported outcome measures (PROMs) into interstitial lung disease (ILD) care and research. This study evaluated the usability and patient experience of the RE-BUILD (Registry for Better Understanding of ILD) application, an ILD-specific smartphone app.Methods: Patients with ILD aged ≥18 years were recruited from three tertiary ILD centres to use the RE-BUILD app for 6 months. The mHealth App Usability Questionnaire (MAUQ) was evaluated at 1, 3 and 6 months and patients received monthly prompts to enter clinical and PROM data. Qualitative interviews regarding patient experience were performed in a subset of 10.Results: Fifty patients, with mean age 66.9 ± 10.3 years, 25 (50%) female were included. Participants used the app for a median of 48 (IQR 21-178.3) sessions, equivalent to 8 sessions (IQR 3.5-29.71) per month. Median number of days that the app was accessed was 37 (IQR 14-96.8), with 13 (26%) patients using the app >30 times per month. The most accessed app feature was physical activity, followed by 'air quality'. Participants agreed or strongly agreed that the app was easy to use (76.0%) easy to learn to use (79.8%) and well-organized with accessible information (74.8%). The median overall MAUQ score for usability was 5.69 (IQR 5.03-6.19). There was also a high rate of engagement with app functionalities.Conclusion: RE-BUILD is a usable and intuitive platform for self-monitoring and data collection in ILD. Patients report a high degree of satisfaction and have provided valuable feedback for its further development.","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reassessing pyrazinamide: Disentangling the myth of dose-dependent hepatotoxicity and advancing dosing strategies in elderly tuberculosis patients. 重新评估吡嗪酰胺：打破剂量依赖性肝毒性的神话，改进老年肺结核患者的用药策略。

IF 6.6 2区医学

Respirology Pub Date : 2024-12-17 DOI: 10.1111/resp.14872

Samadhi Patamatamkul

引用次数: 0

Response to 'Reassessing pyrazinamide: Disentangling the myth of dose-dependent hepatotoxicity and advancing dosing strategies in elderly tuberculosis patients'. 对 "重新评估吡嗪酰胺：打破剂量依赖性肝毒性的神话，推进老年肺结核患者的用药策略 "的回应。

IF 6.6 2区医学

Respirology Pub Date : 2024-12-17 DOI: 10.1111/resp.14873

Jumpei Taniguchi, Shotaro Aso, Hideo Yasunaga

引用次数: 0

Correction to "Predictive role of neutrophil-percentage-to-albumin, neutrophil-to-lymphocyte and eosinophil-to-lymphocyte ratios for mortality in patients with COPD: Evidence from NHANES 2011-2018". 嗜中性粒细胞百分比与白蛋白、嗜中性粒细胞与淋巴细胞和嗜酸性粒细胞与淋巴细胞比率对慢性阻塞性肺病患者死亡率的预测作用：2011-2018 年 NHANES 提供的证据 "的更正。

IF 6.6 2区医学

Respirology Pub Date : 2024-12-17 DOI: 10.1111/resp.14875

引用次数: 0

The potential lipid biomarker 5-HETE for acute exacerbation identified by metabolomics in patients with idiopathic pulmonary fibrosis. 通过代谢组学鉴定特发性肺纤维化患者急性加重的潜在脂质生物标志物 5-HETE。

IF 6.6 2区医学

Respirology Pub Date : 2024-12-16 DOI: 10.1111/resp.14866

Yichao Zhao, Yanchen Shi, Ji Zhang, Huizhe Zhang, Zimu Wang, Shufei Wu, Mingrui Zhang, Mengying Liu, Xu Ye, Huimin Gu, Cheng Jiang, Xiaoling Ye, Huihui Zhu, Qi Li, Xinmei Huang, Mengshu Cao

{"title":"The potential lipid biomarker 5-HETE for acute exacerbation identified by metabolomics in patients with idiopathic pulmonary fibrosis.","authors":"Yichao Zhao, Yanchen Shi, Ji Zhang, Huizhe Zhang, Zimu Wang, Shufei Wu, Mingrui Zhang, Mengying Liu, Xu Ye, Huimin Gu, Cheng Jiang, Xiaoling Ye, Huihui Zhu, Qi Li, Xinmei Huang, Mengshu Cao","doi":"10.1111/resp.14866","DOIUrl":"https://doi.org/10.1111/resp.14866","url":null,"abstract":"Background and objective: Acute exacerbation (AE) is often the fatal complication of idiopathic pulmonary fibrosis (IPF). Emerging evidence indicates that metabolic reprogramming and dysregulation of lipid metabolism are distinctive characteristics of IPF. However, the lipid metabolic mechanisms that underlie the pathophysiology of AE-IPF remain elusive.Methods: Serum samples for pilot study were collected from 34 Controls, 37 stable IPF (S-IPF) cases and 41 AE-IPF patients. UHPLC-MS/MS was utilized to investigate metabolic variations and identify lipid biomarkers in serum. ELISA, quantitative PCR and western blot were employed to validate the identified biomarkers.Results: There were 32 lipid metabolites and 5 lipid metabolism pathways enriched in all IPF patients compared to Controls. In AE-IPF versus S-IPF, 19 lipid metabolites and 12 pathways were identified, with 5-hydroxyeicosatetraenoic Acid (5-HETE) significantly elevated in AE-IPF. Both in internal and external validation cohorts, the serum levels of 5-HETE were significantly elevated in AE-IPF patients compared to S-IPF subjects. Consequently, the indicators related to 5-HETE in lipid metabolic pathway were significantly changed in AE-IPF patients compared with S-IPF cases in the lung tissues. The serum level of 5-HETE was significantly correlated with the disease severity (CT score and PaO2/FiO2 ratio) and survival time. Importantly, the receiver operating characteristic (ROC) curve, Kaplan-Meier analysis and Multivariate Cox regression analysis demonstrated that 5-HETE represents a promising lipid biomarker for the diagnosis and prognosis of AE-IPF.Conclusion: Our study highlights lipid reprogramming as a novel therapeutic approach for IPF, and 5-HETE may be a potential biomarker of AE-IPF patients.","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Building Respirology. 建设反应学。

IF 6.6 2区医学

Respirology Pub Date : 2024-12-16 DOI: 10.1111/resp.14870

Philip Bardin

引用次数: 0

The commercial determinants of respiratory health. 呼吸系统健康的商业决定因素。

IF 6.6 2区医学

Respirology Pub Date : 2024-12-16 DOI: 10.1111/resp.14871

Robert J Hancox

引用次数: 0

Reducing ethnic inequities: Patterns of asthma medication use and hospital discharges in Māori in Aotearoa New Zealand.

IF 6.6 2区医学

Respirology Pub Date : 2024-12-11 DOI: 10.1111/resp.14865

Allie Eathorne, Jonathan Noble, Lee Hatter, Tom Hills, Selwyn Te Paa, Matire Harwood, Mark Weatherall, Richard Beasley

{"title":"Reducing ethnic inequities: Patterns of asthma medication use and hospital discharges in Māori in Aotearoa New Zealand.","authors":"Allie Eathorne, Jonathan Noble, Lee Hatter, Tom Hills, Selwyn Te Paa, Matire Harwood, Mark Weatherall, Richard Beasley","doi":"10.1111/resp.14865","DOIUrl":"https://doi.org/10.1111/resp.14865","url":null,"abstract":"Background and objective: In Aotearoa New Zealand (NZ) widespread transition to budesonide/formoterol maintenance and/or reliever regimens in clinical practice is temporally associated with reduced rates of asthma hospitalization. It is unknown whether this association is observed in Māori, the indigenous population of NZ, who experience a disproportionate burden from asthma. We investigated patterns in asthma medication use and hospital admissions in Māori in NZ.Methods: Review of NZ national dispensing data for asthma inhaler medications and asthma hospital discharge data from January 2013 to December 2023 in the 12+ age group, with calculation of the relative change in dispensed medication and asthma hospitalization rates for Māori and non-Māori. The most recent six-month period, July to December 2023, is compared with the corresponding six-month period 4 years earlier, July to December 2019.Results: Budesonide/formoterol dispensing increased for both Māori and non-Māori for 2019-2023, with a relative 111% and 115% increase, respectively. Between the two periods, asthma hospital discharges reduced from 142.5 to 97.3 per 100,000, absolute difference 45.2 per 100,000, a 32% reduction for Māori; and 49.4-37.9 per 100,000, absolute difference 11.5 per 100,000; a 23% reduction for non-Māori.Conclusion: The temporal association between a marked increase in dispensing of budesonide/formoterol maintenance and/or reliever regimens and reduced asthma hospitalization was observed for Māori and non-Māori, with a greater reduction in asthma hospitalization for Māori. Despite this reduction in health inequities, asthma hospitalization rates are two and a half times greater for Māori compared to non-Māori.","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indigenous peoples, tobacco use and the role of the commercial tobacco industry.

IF 6.6 2区医学

Respirology Pub Date : 2024-12-10 DOI: 10.1111/resp.14869

Raglan Maddox, Lisa J Whop

引用次数: 0

Recommendations from The Medical Education Editor. 医学教育编辑的建议。

IF 6.6 2区医学

Respirology Pub Date : 2024-12-09 DOI: 10.1111/resp.14868

Mark Lavercombe

引用次数: 0

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