Respirology最新文献

{"title":"Microbial Phenotyping in COPD Exacerbations: One Step Closer to Precision-Based Management.","authors":"Carlos Andrés Celis-Preciado, Simon Couillard","doi":"10.1002/resp.70259","DOIUrl":"https://doi.org/10.1002/resp.70259","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming Missed Opportunities and Diagnostic Delay in Interstitial Lung Disease.","authors":"Gin Tsen Chai","doi":"10.1002/resp.70258","DOIUrl":"https://doi.org/10.1002/resp.70258","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WDR63 Promotes Pulmonary Fibrosis Through Facilitating K63-Linked Ubiquitination of p53.","authors":"Yajun Li, Yuexia Yang, Yue Zhang, Feifan Shi, Yingjie Wang, Hongzhi Wen, Xin Pan, Zhongzheng Li, Mengyuan Peng, Juntang Yang, Qiwen Wang, Lan Wang, Guoying Yu","doi":"10.1002/resp.70195","DOIUrl":"10.1002/resp.70195","url":null,"abstract":"<p><strong>Background and objective: </strong>Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease driven by dysregulated alveolar epithelial cells (AECs) and fibroblasts. While aberrant p53 signalling contributes to IPF pathogenesis, the precise mechanism of p53 activation is not well understood. WDR63, a WD40-repeat protein implicated in lung cancer and male infertility, may be functionally relevant in IPF.</p><p><strong>Methods: </strong>The mouse model of bleomycin-induced pulmonary fibrosis was used to investigate the role of WDR63 in IPF. Immunofluorescent staining and Western blotting assays were performed to assess WDR63 expression in samples from IPF patients and lungs from mice with bleomycin-induced fibrosis. Senescence-associated β-galactosidase (SA-β-gal) staining and flow cytometry assays were performed to evaluate the role of WDR63 in the senescence and apoptosis of AECs and lung fibroblasts. Mass spectrometry (MS) and immunoprecipitation were employed to identify potential substrate proteins of WDR63. Ubiquitination assays were utilised to elucidate the mechanisms of p53 stabilisation.</p><p><strong>Results: </strong>WDR63 is significantly upregulated in IPF patients. WDR63 inhibits proliferation and migration while promoting senescence and apoptosis in AECs. In lung fibroblasts, WDR63 increases cellular senescence and facilitates their differentiation into myofibroblasts. WDR63 promotes K63-linked polyubiquitination of p53, while reducing its K48-linked polyubiquitination, thereby stabilising p53 and activating its downstream signalling. Ectopic WDR63 expression exacerbates bleomycin-induced pulmonary fibrosis in vivo, whereas WDR63 silencing attenuates fibrotic progression.</p><p><strong>Conclusion: </strong>WDR63 stabilises p53 through K63-linked polyubiquitination, thereby driving pathological changes in AECs and lung fibroblasts and aggravating pulmonary fibrosis. These findings demonstrate that targeting WDR63 represents a novel therapeutic strategy for IPF.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"509-520"},"PeriodicalIF":6.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic Scarring and a Vulnerable Mucus-Barrier Axis in Ex-Smokers With COPD.","authors":"Mitsuo Sato","doi":"10.1002/resp.70231","DOIUrl":"10.1002/resp.70231","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"428-430"},"PeriodicalIF":6.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Implications of 9th Lung Cancer TNM Classification on Interventional Pulmonology.","authors":"Judith Maria Brock, Daniela Gompelmann","doi":"10.1002/resp.70243","DOIUrl":"10.1002/resp.70243","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"436-438"},"PeriodicalIF":6.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Combined Medical and Surgical Therapy for Resectable NSCLC.","authors":"Adithya Balasubramanian, James Geng, Catherine Williams, Kanishka Rangamuwa, Thomas John","doi":"10.1002/resp.70238","DOIUrl":"10.1002/resp.70238","url":null,"abstract":"<p><p>Non-small cell lung cancer (NSCLC) remains the leading cause of cancer related mortality. Historically, even among patients with resectable disease, most would not survive 5 years after curative intent surgery. However, outcomes continue to improve through parallel advances in surgery and systemic therapy, the latter aiming to eradicate micrometastatic disease that underpins NSCLC relapse. The advent of precision oncology has transformed the management of oncogene-addicted NSCLC, with tyrosine kinase inhibitors (TKIs) demonstrating significant survival improvements in advanced disease. These agents are now demonstrating their efficacy in molecularly defined subsets of resectable NSCLC-specifically EGFR and ALK mutant tumours-whereby adjuvant TKI therapy significantly reduces recurrence compared with historical platinum-based chemotherapy. In parallel, the immunotherapeutic era has ushered in a new paradigm of curative intent therapy, with immune checkpoint inhibitors (ICIs) improving pathological responses and survival in the perioperative setting. Together, these developments continue to redefine personalised, optimal treatment algorithms for resectable NSCLC. This review outlines the biological rationale and clinical evidence for utilising systemic therapy in the perioperative management of NSCLC. We discuss emerging strategies- such as biomarker-driven, risk-adapted and multimodal approaches- designed to further mitigate the risk of potentially fatal relapse whilst avoiding overtreatment for patients with resectable disease.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"443-458"},"PeriodicalIF":6.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of a Cardiopulmonary Exercise Testing-Derived Summed Score in Idiopathic Pulmonary Fibrosis and Connective Tissue Disease-Associated Interstitial Lung Disease: A Prospective Cohort Study.","authors":"Yu-Lin Tsai, Kai-Ming Chang, Chung-Shih Chin, Chiann-Yi Hsu, Yi-Hsuan Yu, Yuan-Yang Cheng, Pin-Kuei Fu","doi":"10.1002/resp.70193","DOIUrl":"10.1002/resp.70193","url":null,"abstract":"<p><strong>Background and objective: </strong>Our previous study demonstrated that a summed score derived from six cardiopulmonary exercise testing (CPET) parameters could predict 1-year mortality in patients with interstitial lung disease (ILD). However, its long-term prognostic value across different ILD aetiologies remains unclear. This study aimed to assess the predictive performance of CPET-derived parameters for long-term outcomes in patients with idiopathic pulmonary fibrosis (IPF) and connective tissue disease-associated ILD (CTD-ILD).</p><p><strong>Methods: </strong>In this prospective cohort study, 210 patients newly diagnosed with ILD between 2018 and 2022 at a tertiary medical centre underwent CPET. A CPET-derived summed score was evaluated for its association with a composite outcome of all-cause mortality or lung transplantation. Cox regression and receiver operating characteristic curve analyses were used to examine predictive ability and identify the optimal cutoff value. Kaplan-Meier survival analysis and log-rank tests compared event-free survival in IPF and CTD-ILD patients.</p><p><strong>Results: </strong>A summed score incorporating five CPET-derived variables was an independent predictor of the composite outcome. Patients with scores of 2-5 had markedly lower event-free survival (44.2%) than those with scores of 0-1 (88.3%). The score demonstrated consistent predictive value in both IPF and CTD-ILD.</p><p><strong>Conclusion: </strong>The CPET-derived summed score is a useful prognostic tool for predicting all-cause mortality or the need for lung transplantation in newly diagnosed ILD patients. It also retains predictive accuracy for long-term outcomes in both IPF and CTD-ILD. External validation in other ILD subtypes is warranted.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT06476470.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"498-508"},"PeriodicalIF":6.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145811135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracic Ultrasound as a Useful Adjunct to Examination of the Respiratory System.","authors":"Fifian Ka-Yan Chiang, Macy Mei-Sze Lui","doi":"10.1002/resp.70260","DOIUrl":"https://doi.org/10.1002/resp.70260","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147820195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward the Development of a Novel Cell Therapy for Pulmonary Arterial Hypertension Using Peripheral Blood Cells.","authors":"Hidekazu Ishida","doi":"10.1002/resp.70247","DOIUrl":"10.1002/resp.70247","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"434-435"},"PeriodicalIF":6.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter From the Sri Lanka College of Pulmonologists.","authors":"Duminda Yasaratne, Gayan Bowatte","doi":"10.1002/resp.70236","DOIUrl":"10.1002/resp.70236","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"541-543"},"PeriodicalIF":6.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}