Respirology最新文献_第2页

Association Between the Visceral Fat-to-Muscle Ratio and Severe Exacerbation of COPD: A Prospective Cohort Study.

IF 6.6 2区医学

Respirology Pub Date : 2025-02-09 DOI: 10.1111/resp.14883

Yuanyuan Li, Lu Wang, Zhen Li, Tao Luo, Qi Sun, Henry S Lynn, Jianghong Dai

{"title":"Association Between the Visceral Fat-to-Muscle Ratio and Severe Exacerbation of COPD: A Prospective Cohort Study.","authors":"Yuanyuan Li, Lu Wang, Zhen Li, Tao Luo, Qi Sun, Henry S Lynn, Jianghong Dai","doi":"10.1111/resp.14883","DOIUrl":"https://doi.org/10.1111/resp.14883","url":null,"abstract":"Background and objective: An imbalanced fat and muscle mass ratio might impact exacerbation of chronic obstructive pulmonary disease (COPD). We investigated the association of visceral fat-to-muscle ratio (VMR) with severe COPD exacerbation requiring hospitalisation.Methods: This prospective cohort study in COPD patients was performed along with the Xinjiang Multi-Ethnic Cohort study between May 2018 and December 2023. Baseline VMR was calculated from visceral fat area and muscle mass measured by bioelectrical impedance analysis. Numbers of COPD exacerbation hospitalizations were monitored. Associations between various variables and exacerbation were assessed by logistics regression and Zero-inflated Poisson regression analyses.Results: A total of 631 COPD patients were included, with 186 (29.48%) and 304 (48.18%) severe COPD exacerbation within 1 and 5 years, respectively. Compared with body mass index and other obesity indicators, VMR had stronger associations with severe exacerbation. A higher VMR was associated with increased risks of 1-year and 5-year exacerbation (odds ratio [OR] = 1.34 and 1.44, respectively). The subgroup female and overweight individuals showed a strong association (female OR = 1.89 and 1.99, overweight OR = 1.80 and 1.88, for 1 and 5-year exacerbation, respectively). The number of COPD exacerbation increased by 46% for each one-point VMR increase. These results remained unchanged in the sensitivity analyses after removing underweight patients or smoke influence, as well as in the competing risk analysis when considering other causes for death.Conclusion: VMR was a risk factors of severe COPD exacerbation. Proactive assessment of VMR might be helpful to guide management of COPD patients.","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-Treatment MMP7 Predicts Progressive Idiopathic Pulmonary Fibrosis in Antifibrotic Treated Patients.

IF 6.6 2区医学

Respirology Pub Date : 2025-02-07 DOI: 10.1111/resp.14894

Roger M Li, Dino B A Tan, Chantalia Tedja, Wendy A Cooper, Helen E Jo, Christopher Grainge, Ian N Glaspole, Nicole Goh, Samantha Ellis, Peter M A Hopkins, Christopher Zappala, Gregory J Keir, Paul N Reynolds, Sally Chapman, E Haydn Walters, Darryl Knight, Svetlana Baltic, HuiJun Chih, Tamera J Corte, Yuben P Moodley

{"title":"Pre-Treatment MMP7 Predicts Progressive Idiopathic Pulmonary Fibrosis in Antifibrotic Treated Patients.","authors":"Roger M Li, Dino B A Tan, Chantalia Tedja, Wendy A Cooper, Helen E Jo, Christopher Grainge, Ian N Glaspole, Nicole Goh, Samantha Ellis, Peter M A Hopkins, Christopher Zappala, Gregory J Keir, Paul N Reynolds, Sally Chapman, E Haydn Walters, Darryl Knight, Svetlana Baltic, HuiJun Chih, Tamera J Corte, Yuben P Moodley","doi":"10.1111/resp.14894","DOIUrl":"https://doi.org/10.1111/resp.14894","url":null,"abstract":"Background and objective: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with a poor prognosis. Antifibrotics slow the decline of pulmonary function after 12-months, but limited studies have examined the role of circulatory biomarkers in antifibrotic treated IPF patients.Methods: Serum from 98 IPF participants, from the Australian Idiopathic Pulmonary Fibrosis Registry were collected at four time-points over 1 year post-antifibrotic treatment and analysed as two separate cohorts. Patients were stratified as progressive, if they experienced ≥ 10% decline in FVC or ≥ 15% decline in DLCO or were deceased within 1 year of treatment initiation: or otherwise as stable. Ten molecules of interest were measured by ELISAs in patient serum.Results: Baseline MMP7 levels were higher in progressive than stable patients in Cohort 1 (p = 0.02) and Cohort 2 (p = 0.0002). Baseline MMP7 levels also best differentiated progressive from stable patients (Cohort 1, AUC = 0.74, p = 0.02; Cohort 2, AUC = 0.81, p = 0.0003). Regression analysis of the combined cohort showed that elevated MMP7 levels predicted 12-month progression (OR = 1.530, p = 0.010) and increased risk of overall mortality (HR = 1.268, p = 0.002). LASSO regression identified a multi-biomarker panel (MMP7, ICAM-1, CHI3L1, CA125) that differentiated progression more accurately than MMP7 alone. Furthermore, GAP combined with MMP7, ICAM-1, CCL18 and SP-D was more predictive of 3-year mortality than GAP alone.Conclusion: MMP7 along with a multi-biomarker and GAP panel can predict IPF progression and mortality, with the potential for optimising management.","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia.

IF 6.6 2区医学

Respirology Pub Date : 2025-02-05 DOI: 10.1111/resp.14893

Yunqing Zhu, Yongbing Lan, Jun Lv, Dianjianyi Sun, Pei Pei, Ling Yang, Iona Y Millwood, Robin G Walters, Yiping Chen, Huaidong Du, Jian Wang, Xiaoming Yang, Rebecca Stevens, Junshi Chen, Zhengming Chen, Liming Li, Canqing Yu

{"title":"Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia.","authors":"Yunqing Zhu, Yongbing Lan, Jun Lv, Dianjianyi Sun, Pei Pei, Ling Yang, Iona Y Millwood, Robin G Walters, Yiping Chen, Huaidong Du, Jian Wang, Xiaoming Yang, Rebecca Stevens, Junshi Chen, Zhengming Chen, Liming Li, Canqing Yu","doi":"10.1111/resp.14893","DOIUrl":"https://doi.org/10.1111/resp.14893","url":null,"abstract":"Background and objective: Previous observational studies reported a complex relationship between snoring and coronary artery disease (CAD). We aimed to estimate the causal associations between snoring and CAD among East Asian people, and the effects independent of BMI.Methods: Based on 497,250 adults from China Kadoorie Biobank (CKB), we performed a conventional prospective analysis between snoring and CAD outcomes, using the multivariable Cox regression. We also leveraged genome-wide association (GWAS) summary statistics of snoring and BMI from CKB (n = 100,626, 47,208 snorers) and CAD outcomes from Biobank of Japan (BBJ, 5891-25,892 cases, 142,336-168,186 controls). Single-variable and multivariable two-sample bi-directional Mendelian randomization (MR) analyses were performed.Results: During a median follow-up of 12.32 years, 48,997 participants developed CAD. Snoring and habitual snoring were associated with incident CAD and myocardial infarction (MI), habitual snoring was also associated with stable angina pectoris (SAP). The HRs (95% CIs) of habitual snoring were 1.06 (1.04, 1.08), 1.06 (1.04, 1.08) and 1.14 (1.03, 1.25). The associations remained among non-adiposity participants. Genetically predicted habitual snoring was associated with CAD and MI, the corresponding IVW-ORs (95% CIs) were 1.09 (1.005, 1.19) and 1.15 (1.05, 1.25). Further adjusted BMI, habitual snoring retained independent effects on MI and CAD, and showed impact on SAP (1.09 [1.01, 1.17]). No reverse associations were observed between CADs on snoring traits.Conclusion: Habitual snoring elevated the risks of total CAD, MI and SAP. The causal associations were independent of BMI. These findings indicated that snoring intervention might contribute to the decrease of CAD risk among Asians.","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynapenia and Sarcopenia as Risk Factors for Mortality in Interstitial Lung Disease. 作为间质性肺病死亡率风险因素的动力性减少症和肌少症

IF 6.6 2区医学

Respirology Pub Date : 2025-02-04 DOI: 10.1111/resp.14892

Alan Aldair Ibarra-Fernández, Robinson Robles-Hernández, Arturo Orea-Tejeda, Dulce González-Islas, Angelia Jiménez-Valentín, Rocío Sánchez-Santillán, Laura Patricia Arcos-Pacheco, Emilio Gutiérrez-Luna, Andrea Zurita-Sandoval, Tomas Peña-Espinosa, Rosaura Gutiérrez-Vargas, Laura Flores-Cisneros

{"title":"Dynapenia and Sarcopenia as Risk Factors for Mortality in Interstitial Lung Disease.","authors":"Alan Aldair Ibarra-Fernández, Robinson Robles-Hernández, Arturo Orea-Tejeda, Dulce González-Islas, Angelia Jiménez-Valentín, Rocío Sánchez-Santillán, Laura Patricia Arcos-Pacheco, Emilio Gutiérrez-Luna, Andrea Zurita-Sandoval, Tomas Peña-Espinosa, Rosaura Gutiérrez-Vargas, Laura Flores-Cisneros","doi":"10.1111/resp.14892","DOIUrl":"https://doi.org/10.1111/resp.14892","url":null,"abstract":"Background and objective: Fibrotic interstitial lung disease (ILD) is associated with high morbidity and mortality. Patients often exhibit impaired nutritional status and alterations in body composition, such as dynapenia and sarcopenia, which correlate with poor pulmonary function, reduced exercise tolerance and diminished quality of life. However, the impact of dynapenia and sarcopenia on prognosis has not been examined extensively in ILD patients. We assessed the impact of dynapenia and sarcopenia as risk factors for mortality and their prevalence in ILD.Methods: Prospective cohort study. ILD was classified into idiopathic pulmonary fibrosis (IPF), connective tissue disease-related ILD (CTD-ILD) and chronic hypersensitivity pneumonitis (CHP). Patients over 18 years old with a confirmed diagnosis of ILD were included, while those with diagnoses of cancer, human immunodeficiency virus and neurological disease were excluded. Dynapenia and sarcopenia were determined according to EWGSOP2 criteria.Results: Ninety-eight ILD patients were included; 33.66% had IPF, 47.96% had CTD-ILD, and 18.37% had CHP. The mean age was 63.89 ± 12.02 years; 37.76% were male. The risk factors associated with mortality included dynapenia (HR: 2.04, 95% CI: 1.10-3.77, p = 0.022), sarcopenia (HR: 1.88, 95% CI; 1.00-3.33, p = 0.049) and exercise tolerance (HR: 0.99, 95% CI; 0.99-0.99, p = 0.023), adjusted for confounding variables. The prevalence of dynapenia was 45% in ILD; 51% in IPF, 35% in CTD-ILD and 61% in CHP. The prevalence of sarcopenia was 29%; both IPF (39%) and CHP (50%) had a higher prevalence of sarcopenia than CTD-ILD (14%).Conclusion: Sarcopenia and dynapenia are independent risk factors for mortality in ILD.","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Opportunity in Respirology.

IF 6.6 2区医学

Respirology Pub Date : 2025-02-03 DOI: 10.1111/resp.14899

Toshiaki Kikuchi

引用次数: 0

Beyond Single Cytokines: Targeting Co-Receptor CD131 in Asthma-COPD Overlap.

IF 6.6 2区医学

Respirology Pub Date : 2025-02-02 DOI: 10.1111/resp.14891

Chantal Donovan

引用次数: 0

Sputum Metagenomics Reveals Multidrug-Resistant Pseudomonas-Dominant Communities in Severe Asthma.

IF 6.6 2区医学

Respirology Pub Date : 2025-02-02 DOI: 10.1111/resp.14890

Sara K Di Simone, Samuel C Forster

引用次数: 0

Allele-specific micro-RNA-mediated regulation of ADAM33 in childhood allergic asthma. 等位基因特异性微 RNA 介导的 ADAM33 在儿童过敏性哮喘中的调控。

IF 6.6 2区医学

Respirology Pub Date : 2025-02-01 Epub Date: 2024-10-30 DOI: 10.1111/resp.14846

Xiang Wen, Juan Zhou, Heping Fang, Juan Li, Run Wang, Dan Zeng, Xiaohong Xie, Yu Deng, Luo Ren, Enmei Liu

{"title":"Allele-specific micro-RNA-mediated regulation of ADAM33 in childhood allergic asthma.","authors":"Xiang Wen, Juan Zhou, Heping Fang, Juan Li, Run Wang, Dan Zeng, Xiaohong Xie, Yu Deng, Luo Ren, Enmei Liu","doi":"10.1111/resp.14846","DOIUrl":"10.1111/resp.14846","url":null,"abstract":"Background and objective: A disintegrin and metalloprotease 33 (ADAM33) is associated with asthma susceptibility, and its genetic variations impact susceptibility and disease severity. However, the mechanisms remain unclear. This study aimed to investigate ADAM33 single nucleotide polymorphisms (SNPs) in childhood asthma susceptibility and explore their regulatory mechanisms.Methods: Eleven selected SNPs in ADAM33 were genotyped and identified the association with asthma susceptibility. In the validation cohort, we measured plasma sADAM33 levels and compared them with disease severity among children with different SNP genotypes. Computational predictions identified miRNAs targeting the SNP, and the impact of the SNP on miRNA regulation was confirmed using a dual luciferase reporter system. Finally, we validated the regulatory role of miRNAs on ADAM33 expression using an in vitro model with upregulated ADAM33 expression.Results: Only rs3918400 was associated with asthma susceptibility. In the validation cohort, children with allergic asthma exhibited higher plasma sADAM33 levels. Among asthmatic children, those with the rs3918400 CT/TT genotype had higher sADAM33 levels, poorer asthma control, more severe airway hyper-responsiveness, lower FEV1% and higher dust mite-specific IgE activity compared to those with the CC genotype. miR-3928-5p bound strongly to the rs3918400 C allele and effectively reduced ADAM33 protein expression in CC genotype cells. However, the binding affinity of miR-3928-5p to the T allele was weaker, resulting in diminished negative regulation of protein expression.Conclusion: The rs3918400 SNP affects the negative regulation of ADAM33 by miR-3928-5p, potentially participating in a complex interplay of processes related to childhood asthma susceptibility.","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"113-123"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary function testing in COPD: Anchoring clinical relevance. 慢性阻塞性肺病肺功能检测：锚定临床相关性。

IF 6.6 2区医学

Respirology Pub Date : 2025-02-01 Epub Date: 2024-12-08 DOI: 10.1111/resp.14867

Bruce R Thompson

引用次数: 0

Lung Cancer in Non-Smokers. 非吸烟者的肺癌。

IF 6.6 2区医学

Respirology Pub Date : 2025-02-01 Epub Date: 2025-01-13 DOI: 10.1111/resp.14879

Akihiko Miyanaga, Masahiro Seike

引用次数: 0