Respirology最新文献

{"title":"Heading in the Right Direction: Statistical Models for Lung Function Trajectories and Their Associations With Biomarkers.","authors":"Andrew Robert Gray","doi":"10.1002/resp.70312","DOIUrl":"10.1002/resp.70312","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"938-939"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards Regional Progress in Lung Health: APSR 2025 Big 5 Lung Diseases Workshop.","authors":"Peter Ab Wark","doi":"10.1002/resp.70310","DOIUrl":"10.1002/resp.70310","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"1050-1052"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards a Tobacco Endgame in Hong Kong: A Pragmatic Model for the Asia-Pacific.","authors":"Sophia Siu-Chee Chan, Shengzhi Zhao","doi":"10.1002/resp.70325","DOIUrl":"https://doi.org/10.1002/resp.70325","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Flow Nasal Oxygen in Early Home Pulmonary Rehabilitation for Exertional Hypoxaemia: A Pilot Randomised Feasibility Trial.","authors":"Yingjuan Mok, Jing Wen Foong, Hang Siang Wong, Edwin Chan Shih-Yen, Norasyikin Hassan, Piyanee Klainin-Yobas, Li Ching Soh, Amanda Soh, Shi Hua Tan, Xuan Han Koh, Poh Choo Tan, Keith Keat Huat Wong","doi":"10.1002/resp.70277","DOIUrl":"10.1002/resp.70277","url":null,"abstract":"<p><strong>Background: </strong>Patients with exertional hypoxaemia (EH) at hospital discharge face rapid deconditioning risks. However, early pulmonary rehabilitation (PR) is limited by exercise intolerance and access barriers. Optimal PR design for this group remains unclear. High-flow nasal oxygen (HFO) may alleviate EH, but its role in home-based PR is unexplored. We aimed to evaluate an early, intensive, home-based PR program and the integration of HFO during exercise training for EH patients post-hospitalisation.</p><p><strong>Methods: </strong>In this pilot feasibility trial, EH patients across respiratory conditions were randomised to PR with HFO (HFO-PR) or PR alone (PR-only). Both groups commenced a three-week home-based PR program (two supervised, three self-directed sessions weekly) within 1 week of discharge. Feasibility was assessed using quantitative and qualitative measures.</p><p><strong>Results: </strong>Fifty-two of 56 patients completed follow-up at 4 weeks. Overall PR program acceptance and uptake were 67% and 62%, respectively. Program completion was lower in the HFO-PR group (60%) compared to the PR-only group (89%), primarily due to reduced adherence to self-directed exercise sessions. Among COPD patients, the 1-min sit-to-stand test at 4 weeks improved by 4.6 repetitions in the HFO group and 5.3 in the PR-only group (adjusted difference in mean change -0.8, 95% CI -4.7 to 3.1). Qualitative findings revealed three themes: Transformations following the intervention, Receiving care and education at home, and Experiencing HFO system. Participants reported challenges with HFO during unsupervised exercise.</p><p><strong>Conclusion: </strong>Early home-based PR for post-hospitalisation EH patients is feasible and safe. However, the addition of HFO was associated with lower adherence, highlighting implementation barriers to address before further evaluation.</p><p><strong>Trial registration: </strong>NCT05752370.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"1029-1040"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finding Their Voice: Online Group Singing for COPD and ILD.","authors":"Renae J McNamara","doi":"10.1002/resp.70303","DOIUrl":"10.1002/resp.70303","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"940-941"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life After Non-COVID-19 Respiratory Viral Illnesses.","authors":"Hanh D Trinh","doi":"10.1002/resp.70328","DOIUrl":"https://doi.org/10.1002/resp.70328","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The SINFONIA Study: A Randomised Controlled Trial to Determine Feasibility and Effectiveness of Online Group Singing for People With COPD or ILD and Breathlessness.","authors":"Natasha Smallwood, Amy Pascoe, Nicole Goh, Stefanie Zappino, Sara Vogrin, Lena Ly, Catherine Buchan, Anna Spathis, Jennifer Philip","doi":"10.1002/resp.70281","DOIUrl":"10.1002/resp.70281","url":null,"abstract":"<p><strong>Background and objective: </strong>People with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) experience chronic breathlessness and reduced quality of life (QOL). Specialised singing programs for people with lung disease may improve QOL and symptoms.</p><p><strong>Methods: </strong>A randomised controlled trial conducted in Australia to determine the feasibility and effectiveness of 12 weeks of online, guided group singing on QOL (primary outcome, as measured by SF36), as compared to usual care in people with COPD or ILD.</p><p><strong>Secondary outcomes: </strong>anxiety, depression, dyspnoea and loneliness. Intervention effectiveness was assessed using mixed effects linear regression.</p><p><strong>Results: </strong>One hundred and one participants were randomised (50 singing, 51 control; 64 COPD, 37 ILD; mean age 69.6 years; 74% women; 42% mMRC = 2, 58% mMRC ≥ 3). The results of the primary endpoint were a mean treatment effect (MTE) of singing of 2.5 points (95% CI -1.9 to 6.8; p = 0.266) on SF-36 mental health score (MCS) and 2.6 points (95% CI -0.9 to 6.1; p = 0.138) on the physical component score (PCS), neither of which were statistically or clinically significant. In the per-protocol analysis, significant improvement in MCS was detected in participants who attended 8 or more sessions (MTE:4.8; 95% CI 0.1 to 9.5; p = 0.047). No significant effects on secondary outcomes were detected. No adverse events were reported.</p><p><strong>Conclusions: </strong>This RCT demonstrated that online group singing is a feasible intervention for people with COPD or ILD and breathlessness. Although the intention-to-treat analysis did not demonstrate effectiveness, per-protocol analyses suggest that singing may improve mental health components of QOL in people with COPD or ILD.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"1003-1013"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Alveolar Proteinosis: Is the Focus in Treatment Shifted From 'Physical' to 'Pharmacological'?","authors":"Yasuhiko Nishioka","doi":"10.1002/resp.70323","DOIUrl":"10.1002/resp.70323","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"942-943"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Physiology and Function at High Altitude: Can Inhalation of CO₂ Compensate for the Effects of Low Oxygen?","authors":"Melissa J Benton","doi":"10.1002/resp.70297","DOIUrl":"10.1002/resp.70297","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"946-947"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary Concise Review 2025: Interstitial Lung Disease.","authors":"Tonia Magrì, Luca Richeldi","doi":"10.1002/resp.70309","DOIUrl":"10.1002/resp.70309","url":null,"abstract":"<p><p>Multidisciplinary discussion remains the cornerstone of ILD diagnosis and management, with recent advances further strengthening the integration of clinical, radiological, pathological, and molecular information. Updated ILD nomenclature and classification better align disease terminology with underlying morphology and pathobiology. Growing emphasis is being placed on the early detection of ILD and on identifying individuals at high risk of progression among those with interstitial lung abnormalities (ILAs). Emerging multi-omic biomarkers and quantitative imaging techniques are enhancing prognostic stratification and may support future precision medicine approaches. Novel antifibrotic therapies and targeted treatments are expanding therapeutic options beyond IPF, although important unmet needs remain regarding patient selection, treatment response, and disease modification. The integration of clinical, radiological, functional, and molecular information will be fundamental to optimize individualized management and improve long-term outcomes in patients with ILDs.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"974-982"},"PeriodicalIF":7.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}