RespirologyPub Date : 2024-12-01Epub Date: 2024-09-26DOI: 10.1111/resp.14838
Fanny Wai San Ko
{"title":"Green energy and sustainability.","authors":"Fanny Wai San Ko","doi":"10.1111/resp.14838","DOIUrl":"10.1111/resp.14838","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"1101-1102"},"PeriodicalIF":5.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-12-01Epub Date: 2024-07-17DOI: 10.1111/resp.14799
Kolton Cobb, Jonathan Kenyon, Juan Lu, Benjamin Krieger, Apostolos Perelas, Patrick Nana-Sinkam, Youngdeok Kim, Paula Rodriguez-Miguelez
{"title":"COPD is associated with increased cardiovascular disease risk independent of phenotype.","authors":"Kolton Cobb, Jonathan Kenyon, Juan Lu, Benjamin Krieger, Apostolos Perelas, Patrick Nana-Sinkam, Youngdeok Kim, Paula Rodriguez-Miguelez","doi":"10.1111/resp.14799","DOIUrl":"10.1111/resp.14799","url":null,"abstract":"<p><strong>Background and objective: </strong>Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide that frequently presents with concomitant cardiovascular diseases. Despite the pathological distinction between individual COPD phenotypes such as emphysema and chronic bronchitis, there is a lack of knowledge about the impact of COPD phenotype on cardiovascular disease risk. Thus, this study aimed to utilize a nationally representative sample to investigate cardiovascular disease prevalence in patients with COPD with emphysema and chronic bronchitis phenotypes.</p><p><strong>Methods: </strong>Data from 31,560 adults including 2504 individuals with COPD, collected as part of the National Health and Nutrition Examination Survey (1999-2018), were examined.</p><p><strong>Results: </strong>A significantly increased cardiovascular disease risk, including coronary heart disease, heart failure, myocardial infarction and stroke, was identified in patients with COPD among all disease phenotypes. Particularly, compared to those without COPD, individuals with chronic bronchitis presented with 1.76 (95% CI: 1.41-2.20) times greater odds, individuals with emphysema with 2.31 (95% CI: 1.80-2.96) times greater odds, while those with a concurrent phenotype (combined chronic bronchitis and emphysema) exhibited 2.98 (95% CI: 2.11-4.21) times greater odds of reporting cardiovascular diseases.</p><p><strong>Conclusion: </strong>Our data confirms that patients with COPD present an elevated risk of developing cardiovascular disease among all phenotypes, with the most marked increase being in those with concurrent chronic bronchitis and emphysema phenotypes. These findings emphasize the need for awareness and appropriate cardiovascular screening in COPD.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"1047-1057"},"PeriodicalIF":6.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-12-01Epub Date: 2024-10-22DOI: 10.1111/resp.14848
Yuben Moodley
{"title":"Contemporary Concise Review 2023: Interstitial lung disease.","authors":"Yuben Moodley","doi":"10.1111/resp.14848","DOIUrl":"10.1111/resp.14848","url":null,"abstract":"<p><p>In this review, we have discussed several important developments in 2023 in Interstitial Lung Disease (ILD). The association of pollution with genetic predispositions increased the risk of Idiopathic Pulmonary Fibrosis (IPF). An interesting comorbidity of malnutrition was not adequately recognized in ILD. Novel genes have been identified in IPF involving predominantly short telomere length and surfactant protein production leading to alveolar epithelial cell dysfunction. Genetics also predicted progression in IPF. Crosstalk between vascular endothelial cells and fibroblasts in IPF mediated by bone morphogenic protein signalling may be important for remodelling of the lung. A novel modality for monitoring of disease included the 4-min gait speed. New treatment modalities include inhaled pirfenidone, efzofitimod, for sarcoidosis, and earlier use of immunosuppression in connective tissue disease-ILD.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"1095-1100"},"PeriodicalIF":6.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-12-01Epub Date: 2024-10-24DOI: 10.1111/resp.14841
Anne-Marie Russell, Kathleen O Lindell
{"title":"Prologue: Leading women in respiratory clinical sciences.","authors":"Anne-Marie Russell, Kathleen O Lindell","doi":"10.1111/resp.14841","DOIUrl":"10.1111/resp.14841","url":null,"abstract":"<p><p>Special Series: Leading Women in Respiratory Clinical Sciences Series Editors: Anne-Marie Russell and Kathleen O Lindell See related Letter.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"1011-1012"},"PeriodicalIF":5.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-12-01Epub Date: 2024-10-24DOI: 10.1111/resp.14842
Anne-Marie Russell
{"title":"Letter from the UK: Developing the ecosystem for career advancement of women.","authors":"Anne-Marie Russell","doi":"10.1111/resp.14842","DOIUrl":"10.1111/resp.14842","url":null,"abstract":"<p><p>Special Series: Leading Women in Respiratory Clinical Sciences Series Editors: Anne-Marie Russel and Kathleen O Lindell See related Editorial.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"1107-1108"},"PeriodicalIF":5.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-12-01Epub Date: 2024-08-19DOI: 10.1111/resp.14817
Thomas McCrabb, Brigitte Borg, Caroline X Gao, Catherine Smith, Claire F O'Sullivan, David Brown, Jillian Ikin, Annie Makar, Tyler Lane, Michael J Abramson, Bruce R Thompson
{"title":"Ventilation heterogeneity is increased in adults exposed to coal mine fire-related PM<sub>2.5</sub>.","authors":"Thomas McCrabb, Brigitte Borg, Caroline X Gao, Catherine Smith, Claire F O'Sullivan, David Brown, Jillian Ikin, Annie Makar, Tyler Lane, Michael J Abramson, Bruce R Thompson","doi":"10.1111/resp.14817","DOIUrl":"10.1111/resp.14817","url":null,"abstract":"<p><strong>Background and objectives: </strong>The Hazelwood Health Study was set up to study long-term health effects of a mine fire that blanketed residents of the Latrobe Valley with smoke for 45 days in 2014. The Respiratory Stream specifically assessed the impact of fine particulate matter <2.5 μm diameter (PM<sub>2.5</sub>) exposure from mine fire smoke on lung health. The multiple breath nitrogen washout (MBW) test assesses ventilation heterogeneity, which may detect sub-clinical airways dysfunction not identified using standard tests such as spirometry. This analysis assessed the association of PM<sub>2.5</sub> exposure with measures of ventilation heterogeneity.</p><p><strong>Methods: </strong>Exposed (Morwell) and unexposed (Sale) participants were recruited 3.5-4 years after the fire from those who had participated in an Adult Survey. MBW was performed to measure lung clearance index (LCI), functional residual capacity (FRC), acinar (Sacin) and conductive (Scond) ventilation heterogeneity. PM<sub>2.5</sub> exposure was estimated with emission and chemical transport models. Multivariable linear regression models were fitted controlling for confounders.</p><p><strong>Results: </strong>We recruited 519 participants. MBW tests were conducted on 504 participants with 479 acceptable test results (40% male; 313 exposed, 166 unexposed). Exposure to mine fire-related PM<sub>2.5</sub> was associated with increasing Scond (β = 1.57/kL, 95%CI: 0.20-2.95, p = 0.025), which was comparable to the estimated effect on Scond of 4.7 years of aging. No other MBW outcomes were statistically different.</p><p><strong>Conclusion: </strong>Increasing exposure to PM<sub>2.5</sub> was associated with increased ventilation heterogeneity in the conductive region of the lungs 4 years after the event.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"1058-1066"},"PeriodicalIF":5.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-11-14DOI: 10.1111/resp.14855
Karen Royals, Sheree Smith
{"title":"Leading women in respiratory clinical sciences: Letter from Australia.","authors":"Karen Royals, Sheree Smith","doi":"10.1111/resp.14855","DOIUrl":"10.1111/resp.14855","url":null,"abstract":"<p><p>Special Series: Leading Women in Respiratory Clinical Sciences Series Editors: Anne-Marie Russel and Kathleen O Lindell See related Editorial.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-11-13DOI: 10.1111/resp.14852
Danielle F Wurzel, Brett D Montgomery, Natalie Anderson, Elena K Schneider-Futschik, Johnson George, Sinthia Bosnic-Anticevich, Emily Stone, Robert J Hancox, James Fingleton, Stephanie Kuek, Helen Tope, John Blakey
{"title":"Environmental impact of inhaled medicines: A Thoracic Society of Australia and New Zealand position statement.","authors":"Danielle F Wurzel, Brett D Montgomery, Natalie Anderson, Elena K Schneider-Futschik, Johnson George, Sinthia Bosnic-Anticevich, Emily Stone, Robert J Hancox, James Fingleton, Stephanie Kuek, Helen Tope, John Blakey","doi":"10.1111/resp.14852","DOIUrl":"https://doi.org/10.1111/resp.14852","url":null,"abstract":"<p><p>Globally, more than 1.2 billion inhalers are purchased for asthma and chronic obstructive pulmonary disease (COPD) annually. In Australia and New Zealand, pressurized metered dose inhalers (pMDIs) are the leading delivery device prescribed and pMDI salbutamol can be purchased over the counter in Australia. These inhalers are a major contributor to healthcare related greenhouse gases. This is due to the propellants that they currently contain which have extremely high global warming potential (GWP). In this position paper, we report the findings of a Thoracic Society of Australia and New Zealand (TSANZ) working group on the environmental impact of inhaled respiratory medicines. We reviewed the use of inhaled medicines in Australia and New Zealand and their contribution to climate change and other environmental degradation. We propose strategies for health professionals and consumers to reduce environmental impact in the management of airway diseases. These include accurate diagnosis to avoid unnecessary treatment, better disease control to minimize the need for reliever therapy and actively choosing inhaler devices with lower environmental impacts when clinically appropriate. Inhaler selection should be tailored to the individual, aiming to achieve the best possible clinical outcome. Choosing an appropriate inhaler for an individual involves consideration of factors such as dexterity, inspiratory capacity and cost. In our current climate emergency and with the availability of lower carbon alternatives, health professionals should also consider environmental impact.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-11-04DOI: 10.1111/resp.14851
Christine R Jenkins
{"title":"A visit to the gallery.","authors":"Christine R Jenkins","doi":"10.1111/resp.14851","DOIUrl":"https://doi.org/10.1111/resp.14851","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}