Respirology最新文献_第8页

Uncontrolled mild-to-moderate asthma may not be mild or moderate, or even asthma: The benefits of early phenotyping. 不受控制的轻度至中度哮喘可能不是轻度或中度，甚至不是哮喘：早期表型的好处。

IF 6.6 2区医学

Respirology Pub Date : 2024-07-11 DOI: 10.1111/resp.14795

James Melhorn, Gabriel Lavoie

引用次数: 0

Pyrazinamide in elderly people. 在老年人中使用吡嗪酰胺。

IF 6.6 2区医学

Respirology Pub Date : 2024-07-05 DOI: 10.1111/resp.14791

Avnish Sandhu, Dana Kissner

引用次数: 0

DUETS for Light's in separating exudate from transudate. DUETS 用于分离渗出液和渗出液。

IF 6.6 2区医学

Respirology Pub Date : 2024-07-03 DOI: 10.1111/resp.14780

Astrid Gardiner, Ryan Ling, Yiong-Huak Chan, Jose Porcel, Y C Gary Lee, Chia-Meng Teoh, Mei-Fong Liew, Jeevesh Kapur, Seow-Ping Low, Pyng Lee

{"title":"DUETS for Light's in separating exudate from transudate.","authors":"Astrid Gardiner, Ryan Ling, Yiong-Huak Chan, Jose Porcel, Y C Gary Lee, Chia-Meng Teoh, Mei-Fong Liew, Jeevesh Kapur, Seow-Ping Low, Pyng Lee","doi":"10.1111/resp.14780","DOIUrl":"https://doi.org/10.1111/resp.14780","url":null,"abstract":"Background: Fifty years since its inception, Light's criteria have aided in classifying pleural effusions (PEs) as exudates if 1 or more criteria are met. Thoracic ultrasound (US) emerges as a non-invasive technique for point of care use especially if pleural procedures are contemplated.Objective: We aimed to develop a score based on radiological and US features that could separate exudates from transudates without serum and pleural fluid biochemical tests necessary for Light's criteria.Methods: A prospective review of consecutive patients with PE who underwent thoracocentesis was performed. CXRs were evaluated for laterality followed by US for echogenicity, pleural nodularity, thickening and septations. PE was classified as exudate or transudate according to Light's criteria and corroborated with albumin gradient. A score combining radiological and US features was developed.Results: We recruited 201 patients with PE requiring thoracocentesis. Mean age was 64 years, 51% were females, 164 (81.6%) were exudates, and 37 (18.4%) were transudates. Assigning 1-point for Diaphragmatic nodularity, Unilateral, Echogenicity, Pleural Thickening and Septations, DUETS ranged from 1 to 5. DUETS ≥2 indicated high likelihood for exudate (PPV 98.8%, NPV 100%) with 1% misclassification versus 6.9% using Light's criteria (p < 0.001).Conclusion: DUETS separated exudates from transudates with good accuracy, and could obviate paired serum and pleural fluid tests necessary for Light's criteria computation. Our study reflected real world practice where DUETS performed better than Light's criteria for PE that arose from more than one disease processes, and in the evaluation of patients with PE who have received diuretics.","PeriodicalId":21129,"journal":{"name":"Respirology","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

World Association for Bronchology and Interventional Pulmonology (WABIP) guidelines on airway stenting for malignant central airway obstruction. 世界支气管和介入肺科协会（WABIP）关于气道支架治疗恶性中央气道阻塞的指南。

IF 6.6 2区医学

Respirology Pub Date : 2024-07-01 Epub Date: 2024-05-29 DOI: 10.1111/resp.14764

Udit Chaddha, Abhinav Agrawal, Jonathan Kurman, Rosamaria Ortiz-Comino, Herve Dutau, Lutz Freitag, Rocco Trisolini, Christophe Dooms, Lina Zuccatosta, Stefano Gasparini, Felix Herth, Hideo Saka, Pyng Lee, David Fielding, Masahide Oki, Antoni Rosell, Septimiu Murgu

{"title":"World Association for Bronchology and Interventional Pulmonology (WABIP) guidelines on airway stenting for malignant central airway obstruction.","authors":"Udit Chaddha, Abhinav Agrawal, Jonathan Kurman, Rosamaria Ortiz-Comino, Herve Dutau, Lutz Freitag, Rocco Trisolini, Christophe Dooms, Lina Zuccatosta, Stefano Gasparini, Felix Herth, Hideo Saka, Pyng Lee, David Fielding, Masahide Oki, Antoni Rosell, Septimiu Murgu","doi":"10.1111/resp.14764","DOIUrl":"10.1111/resp.14764","url":null,"abstract":"Malignant Central Airway Obstruction (MCAO) encompasses significant and symptomatic narrowing of the central airways that can occur due to primary lung cancer or metastatic disease. Therapeutic bronchoscopy is associated with high technical success and symptomatic relief and includes a wide range of airway interventions including airway stents. Published literature suggests that stenting practices vary significantly across the world primarily due to lack of guidance. This document aims to address this knowledge gap by addressing relevant questions related to airway stenting in MCAO. An international group of 17 experts from 17 institutions across 11 countries with experience in using airway stenting for MCAO was convened as part of this guideline statement through the World Association for Bronchology and Interventional Pulmonology (WABIP). We performed a literature and internet search for reports addressing six clinically relevant questions. This guideline statement, consisting of recommendations addressing these six PICO questions, was formulated by a systematic and rigorous process involving the evaluation of published evidence, augmented with expert experience when necessary. Panel members participated in the development of the final recommendations using the modified Delphi technique.","PeriodicalId":21129,"journal":{"name":"Respirology","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The challenge of interpreting diminished mid-expiratory flow in the presence of normal FEV₁ and FVC. 在 FEV1 和 FVC 正常的情况下解释呼气中流量减少的挑战。

IF 6.9 2区医学

Respirology Pub Date : 2024-07-01 Epub Date: 2024-05-21 DOI: 10.1111/resp.14756

Andre Gie, Pierre Goussard

引用次数: 0

Recommendations from The Medical Education Editor. 医学教育编辑的建议。

IF 6.9 2区医学

Respirology Pub Date : 2024-07-01 Epub Date: 2024-05-30 DOI: 10.1111/resp.14759

Mark Lavercombe

引用次数: 0

Effect of off-label targeted drugs on long-term survival in chronic thromboembolic pulmonary hypertension: Insights from a national multicentre prospective registry. 标签外靶向药物对慢性血栓栓塞性肺动脉高压患者长期生存的影响：全国多中心前瞻性登记的启示。

IF 6.6 2区医学

Respirology Pub Date : 2024-07-01 Epub Date: 2024-03-17 DOI: 10.1111/resp.14700

Wanying Xia, Yuling Qian, Yangyi Lin, Ruilin Quan, Yuanhua Yang, Zhenwen Yang, Hongyan Tian, Shengqing Li, Jieyan Shen, Yingqun Ji, Qing Gu, Huijun Han, Changming Xiong, Jianguo He

{"title":"Effect of off-label targeted drugs on long-term survival in chronic thromboembolic pulmonary hypertension: Insights from a national multicentre prospective registry.","authors":"Wanying Xia, Yuling Qian, Yangyi Lin, Ruilin Quan, Yuanhua Yang, Zhenwen Yang, Hongyan Tian, Shengqing Li, Jieyan Shen, Yingqun Ji, Qing Gu, Huijun Han, Changming Xiong, Jianguo He","doi":"10.1111/resp.14700","DOIUrl":"10.1111/resp.14700","url":null,"abstract":"Background and objective: Off-label pulmonary arterial hypertension (PAH)-targeted drugs are commonly prescribed for non-operated chronic thromboembolic pulmonary hypertension (CTEPH), but their effect on the long-term prognosis of CTEPH remains unknown. This study investigated the effect of off-label PAH-targeted drugs on the long-term survival of CTEPH patients.Methods: CTEPH patients were enrolled from a prospective multicentre national registry. Except for licensed riociguat and treprostinil, other PAH-targeted drugs were off-label. In the original and propensity score-matched (PSM) samples, five-year survival was compared in two groups: (a) patients not receiving off-label PAH-targeted drugs (control) versus (b) patients receiving off-label PAH-targeted drugs (treatment). The latter group was investigated for the effect of started off-label PAH-targeted drugs at baselines (initial) or during follow-up (subsequent).Results: Of 347 enrolled patients, 212 were treated with off-label PAH-targeted drugs initially (n = 173) or subsequently (n = 39), and 135 were untreated. The 1-, 2-, 3- and 5-year survival of the treatment group was significantly higher than that of the control group (97.1% vs. 89.4%, 92.3% vs. 82.1%, 83.2% vs. 75.1% and 71.1% vs. 55.3%, respectively, log-rank test, p = 0.005). Initial treatment was correlated with better 5-year survival after excluding patients with subsequent treatment to reduce the immortal-time bias (hazard ratio: 0.611; 95% CI: 0.397-0.940; p = 0.025). In PSM samples, patients given initial treatment showed significantly better 5-year survival than untreated patients (68.9% vs. 49.3%, log-rank test, p = 0.008).Conclusion: Off-label targeted drugs contributed to improved long-term survival in CTEPH patients receiving pharmacotherapies.","PeriodicalId":21129,"journal":{"name":"Respirology","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of surgical lung biopsy on lung function and survival in patients with idiopathic pulmonary fibrosis in a multi-centre registry cohort. 多中心登记队列中手术肺活检对特发性肺纤维化患者肺功能和存活率的影响。

IF 6.6 2区医学

Respirology Pub Date : 2024-07-01 Epub Date: 2024-03-04 DOI: 10.1111/resp.14695

Veronica Marcoux, Stacey D Lok, Prosanta Mondal, Deborah Assayag, Jolene H Fisher, Shane Shapera, Julie Morisset, Hélène Manganas, Charlene D Fell, Nathan Hambly, P Gerard Cox, Martin Kolb, Andrea S Gershon, Teresa To, Mohsen Sadatsafavi, Nasreen Khalil, Alyson W Wong, Pearce G Wilcox, Christopher J Ryerson, Thao Vu, Kerri A Johannson

{"title":"Impact of surgical lung biopsy on lung function and survival in patients with idiopathic pulmonary fibrosis in a multi-centre registry cohort.","authors":"Veronica Marcoux, Stacey D Lok, Prosanta Mondal, Deborah Assayag, Jolene H Fisher, Shane Shapera, Julie Morisset, Hélène Manganas, Charlene D Fell, Nathan Hambly, P Gerard Cox, Martin Kolb, Andrea S Gershon, Teresa To, Mohsen Sadatsafavi, Nasreen Khalil, Alyson W Wong, Pearce G Wilcox, Christopher J Ryerson, Thao Vu, Kerri A Johannson","doi":"10.1111/resp.14695","DOIUrl":"10.1111/resp.14695","url":null,"abstract":"Background and objective: Establishing an accurate and timely diagnosis of idiopathic pulmonary fibrosis (IPF) is essential for appropriate management and prognostication. In some cases, surgical lung biopsy (SLB) is performed but carries non-negligible risk. The objective of this retrospective study was to determine if SLB is associated with accelerated lung function decline in patients with IPF using the Canadian Registry for Pulmonary Fibrosis.Methods: Linear mixed models and Cox proportional hazards regression models were used to compare decline in forced vital capacity (FVC)%, diffusion capacity of the lung (DLCO%) and risk of death or lung transplantation between SLB and non-SLB patients. Adjustments were made for baseline age, sex, smoking history, antifibrotic use, and lung function. A similar analysis compared lung function changes 12 months pre- and post-SLB.Results: A total of 81 SLB patients and 468 non-SLB patients were included. In the SLB group, the post-biopsy annual FVC% decline was 2.0% (±0.8) in unadjusted, and 2.1% (±0.8) in adjusted models. There was no difference in FVC% decline, DLCO% decline, or time to death or lung transplantation between the two groups, in adjusted or unadjusted models (all p-values >0.07). In the pre-post SLB group, no differences were identified in FVC% decline in unadjusted or adjusted models (p = 0.07 for both).Conclusion: No association between SLB and lung function decline or risk of death or lung transplantation was identified in this multi-centre study of patients with IPF.","PeriodicalId":21129,"journal":{"name":"Respirology","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Childhood disadvantage-Factoring it in. 儿童劣势--考虑到这一点。

IF 6.6 2区医学

Respirology Pub Date : 2024-07-01 Epub Date: 2024-05-15 DOI: 10.1111/resp.14751

Diane M Gray

引用次数: 0

Abstracts of the 15th Australasian Cystic Fibrosis Conference, 2-4 August 2024. 第 15 届澳大利亚囊性纤维化会议摘要，2024 年 8 月 2-4 日。

IF 6.6 2区医学

Respirology Pub Date : 2024-07-01 DOI: 10.1111/resp.14771

引用次数: 0