RespirologyPub Date : 2024-11-01Epub Date: 2024-08-15DOI: 10.1111/resp.14811
Po-Wei Hu, Chun-Ku Chen, Yi-Han Hsiao, Ching-Yao Weng, Ying-Chi Lee, Kang-Cheng Su, Jia-Yih Feng, Kun-Ta Chou, Diahn-Warng Perng, Hsin-Kuo Ko
{"title":"Correlations between blood vessel distribution, lung function and structural change in idiopathic pulmonary fibrosis.","authors":"Po-Wei Hu, Chun-Ku Chen, Yi-Han Hsiao, Ching-Yao Weng, Ying-Chi Lee, Kang-Cheng Su, Jia-Yih Feng, Kun-Ta Chou, Diahn-Warng Perng, Hsin-Kuo Ko","doi":"10.1111/resp.14811","DOIUrl":"10.1111/resp.14811","url":null,"abstract":"<p><strong>Background and objective: </strong>Correlations between the image analysis of CT scan, lung function and quality of life in patients with idiopathic pulmonary fibrosis (IPF) remain unclear. This study aimed to investigate the impacts of pulmonary blood-vessel distribution and the extent of fibrosis on the lung function and quality of life of patients with IPF.</p><p><strong>Methods: </strong>Patients were enrolled in an IPF registry and had completed pulmonary function tests, chest HRCT, St. George Respiratory Questionnaire (SGRQ) and echocardiography. Pulmonary blood-vessel distribution, specific image-derived airway volume (siVaw) and fibrosis extent (siVfib) were quantitatively calculated by functional respiratory imaging on HRCT.</p><p><strong>Results: </strong>The study subjects were categorized into DLco <40% pred. (n = 40) and DLco ≥40% pred. (n = 19) groups. Patients with DLco <40% pred. had significantly higher scores of SGRQ, composite physiologic index (CPI), exercise oxygen desaturation (∆SpO<sub>2</sub>), siVaw, lower FVC% pred. and 6-minute walking distance% pred. The proportion of small blood vessels in the upper lobes (BV5PR-UL) was significantly correlated with CPI, DLco % Pred., FVC% pred., SGRQ and ∆SpO<sub>2</sub>. Only BV5PR-UL had a significant impact on all indices but not BV5PR in the lower lobes (BV5PR-LL). siVfib was significantly negatively correlated with BV5PR-UL, DLco% pred. and FVC% pred., as well as positively correlated with CPI, ∆SpO<sub>2</sub> and siVaw.</p><p><strong>Conclusion: </strong>BV5PR-UL and siVfib had significant correlations with lung function and may become important indicators to assess the severity of IPF and the impact on quality of life.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"962-968"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-11-01DOI: 10.1111/resp.14835
{"title":"APSR Annual Conference - 28<sup>th</sup> Congress of the Asian Pacific Society of Respirology, 7-10 November 2024, Hong Kong.","authors":"","doi":"10.1111/resp.14835","DOIUrl":"10.1111/resp.14835","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":"29 Suppl 3 ","pages":"3-256"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-11-01Epub Date: 2024-08-27DOI: 10.1111/resp.14824
Ken Ka Pang Chan, David Shu Cheong Hui
{"title":"Letter from Hong Kong: Vaccination trends for respiratory viral infections in Hong Kong.","authors":"Ken Ka Pang Chan, David Shu Cheong Hui","doi":"10.1111/resp.14824","DOIUrl":"10.1111/resp.14824","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"998-1000"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-11-01Epub Date: 2024-07-11DOI: 10.1111/resp.14795
James Melhorn, Gabriel Lavoie
{"title":"Uncontrolled mild-to-moderate asthma may not be mild or moderate, or even asthma: The benefits of early phenotyping.","authors":"James Melhorn, Gabriel Lavoie","doi":"10.1111/resp.14795","DOIUrl":"10.1111/resp.14795","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"929-931"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-11-01Epub Date: 2024-07-25DOI: 10.1111/resp.14806
Noeul Kang, Joo-Hee Kim, So Ri Kim
{"title":"Letter from Korea-Oral corticosteroid stewardship in Korea: Insights from the Korean Severe Asthma Registry (KoSAR).","authors":"Noeul Kang, Joo-Hee Kim, So Ri Kim","doi":"10.1111/resp.14806","DOIUrl":"10.1111/resp.14806","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"1001-1003"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-11-01Epub Date: 2024-08-12DOI: 10.1111/resp.14818
Tai Joon An, Jangwon Lee, Myoungin Shin, Chin Kook Rhee
{"title":"Seasonality of common respiratory viruses: Analysis of nationwide time-series data.","authors":"Tai Joon An, Jangwon Lee, Myoungin Shin, Chin Kook Rhee","doi":"10.1111/resp.14818","DOIUrl":"10.1111/resp.14818","url":null,"abstract":"<p><strong>Background and objective: </strong>Understanding the seasonal behaviours of respiratory viruses is crucial for preventing infections. We evaluated the seasonality of respiratory viruses using time-series analyses.</p><p><strong>Methods: </strong>This study analysed prospectively collected nationwide surveillance data on eight respiratory viruses, gathered from the Korean Influenza and Respiratory Surveillance System. The data were collected on a weekly basis by 52 nationwide primary healthcare institutions between 2015 and 2019. We performed Spearman correlation analyses, similarity analyses via dynamic time warping (DTW) and seasonality analyses using seasonal autoregressive integrated moving average (SARIMA).</p><p><strong>Results: </strong>The prevalence of rhinovirus (RV, 23.6%-31.4%), adenovirus (AdV, 9.2%-16.6%), human coronavirus (HCoV, 3.0%-6.6%), respiratory syncytial virus (RSV, 11.7%-20.1%), influenza virus (IFV, 11.7%-21.5%), parainfluenza virus (PIV, 9.2%-12.6%), human metapneumovirus (HMPV, 5.6%-6.9%) and human bocavirus (HBoV, 5.0%-6.4%) were derived. Most of them exhibited a high positive correlation in Spearman analyses. In DTW analyses, all virus data from 2015 to 2019, except AdV, exhibited good alignments. In SARIMA, AdV and RV did not show seasonality. Other viruses showed 12-month seasonality. We describe the viruses as winter viruses (HCoV, RSV and IFV), spring/summer viruses (PIV, HBoV), a spring virus (HMPV) and all-year viruses with peak incidences during school periods (RV and AdV).</p><p><strong>Conclusion: </strong>This is the first study to comprehensively analyse the seasonal behaviours of the eight most common respiratory viruses using nationwide, prospectively collected, sentinel surveillance data.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"985-993"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-11-01Epub Date: 2024-09-15DOI: 10.1111/resp.14829
David C L Lam, Yoshinori Hasegawa, Kwun M Fong, Chul-Gyu Yoo
{"title":"World Lung Day 2024-Clean air and healthy lungs for all.","authors":"David C L Lam, Yoshinori Hasegawa, Kwun M Fong, Chul-Gyu Yoo","doi":"10.1111/resp.14829","DOIUrl":"10.1111/resp.14829","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"940-941"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-11-01Epub Date: 2024-06-10DOI: 10.1111/resp.14774
Jon R Konradsen, Stina Selberg, Maria Ödling, Johanna Karlsson Sundbaum, Apostolos Bossios, Caroline Stridsman
{"title":"Treatable traits and exacerbation risk in patients with uncontrolled asthma prescribed GINA step 1-3 treatment: A nationwide asthma cohort study.","authors":"Jon R Konradsen, Stina Selberg, Maria Ödling, Johanna Karlsson Sundbaum, Apostolos Bossios, Caroline Stridsman","doi":"10.1111/resp.14774","DOIUrl":"10.1111/resp.14774","url":null,"abstract":"<p><strong>Background and objective: </strong>Uncontrolled asthma in patients treated for mild/moderate disease could be caused by non-pulmonary treatable traits (TTs) that affect asthma control negatively. We aimed to identify demographic characteristics, behavioural (smoking) and extrapulmonary (obesity, comorbidities) TTs and the risk for future exacerbations among patients with uncontrolled asthma prescribed step 1-3 treatment according to the Global Initiative for Asthma (GINA).</p><p><strong>Methods: </strong>Twenty-eight thousand five hundred eighty-four asthma patients (≥18 y) with a registration in the Swedish National Airway Register between 2017 and 2019 were included (index-date). The database was linked to other national registers to obtain information on prescribed drugs 2-years pre-index and exacerbations 1-year post-index. Asthma treatment was classified into step 1-3 or 4-5, and uncontrolled asthma was defined based on symptom control, exacerbations and lung function.</p><p><strong>Results: </strong>GINA step 1-3 included 17,318 patients, of which 9586 (55%) were uncontrolled (UCA 1-3). In adjusted analyses, UCA 1-3 was associated with female sex (OR 1.34, 95% CI 1.27-1.41), older age (1.00, 1.00-1.00), primary education (1.30, 1.20-1.40) and secondary education (1.19, 1.12-1.26), and TTs such as smoking (1.25, 1.15-1.36), obesity (1.23, 1.15-1.32), cardiovascular disease (1.12, 1.06-1.20) and depression/anxiety (1.13, 1.06-1.21). Furthermore, UCA 1-3 was associated with future exacerbations; oral corticosteroids (1.90, 1.74-2.09) and asthma hospitalization (2.55, 2.17-3.00), respectively, also when adjusted for treatment step 4-5.</p><p><strong>Conclusion: </strong>Over 50% of patients treated for mild/moderate asthma had an uncontrolled disease. Assessing and managing of TTs such as smoking, obesity and comorbidities should be conducted in a holistic manner, as these patients have an increased risk for future exacerbations.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"942-950"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141301517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RespirologyPub Date : 2024-11-01Epub Date: 2024-09-04DOI: 10.1111/resp.14827
Natasha Smallwood
{"title":"My family and other animals.","authors":"Natasha Smallwood","doi":"10.1111/resp.14827","DOIUrl":"10.1111/resp.14827","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"994-995"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}