Respirology最新文献

{"title":"Impact of the Race-Neutral Equation on Mortality Risk Prediction in Korean Patients With Chronic Obstructive Pulmonary Disease.","authors":"Kwonhyung Hyung, Hyun Woo Lee, Joon Young Choi, Deog Kyeom Kim, Yong Il Hwang, Ki-Eun Hwang, Hyun Jung Kim, Ji-Yong Moon, Kwang Ha Yoo, Chang-Hoon Lee","doi":"10.1111/resp.70052","DOIUrl":"10.1111/resp.70052","url":null,"abstract":"<p><strong>Background and objective: </strong>Recently, GLI-2022, a race-neutral reference equation, was proposed for spirometric interpretation. However, the impact of using the GLI-2022 in predicting mortality risk has not been fully investigated. This study determined whether the GOLD grades based on GLI-2022 or race-specific equations are overestimated or underestimated in terms of mortality risk prediction among Korean patients with COPD.</p><p><strong>Methods: </strong>The participants were enrolled in a prospective COPD cohort study conducted between 2005 and 2022. Patients were classified into GOLD 1 to GOLD 4 based on the post-bronchodilator forced expiratory volume in 1 s (FEV₁) % predicted using the GLI-2022, GLI Northeast Asian (GLI-2012), Choi's, and KNHANES-VI reference equations. The risk of all-cause mortality was compared between GOLD grades calculated using different equations.</p><p><strong>Results: </strong>Among 1989 patients with COPD, 336 died during a median follow-up of 5.0 years (interquartile range, 3.1-7.3). The GLI-2022 estimated FEV₁% predicted lower than those of GLI-2012, Choi's, and KNHANES-VI. No differences were found in the discrimination or calibration between the mortality prediction models. Rather, the GLI-2022 equation discriminated the mortality risk between the GOLD 1 and GOLD 2 groups (adjusted hazard ratio [aHR], 1.46; 95% confidence interval [CI], 1.05-2.03); however, the race-specific equations did not (Choi's: aHR, 1.22; 95% CI, 0.80-1.85; KNHANES-VI: aHR, 1.19; 95% CI, 0.77-1.82).</p><p><strong>Conclusion: </strong>Our results suggest that race-specific equations may overestimate the severity of airflow obstruction in Korean patients with mild COPD, which supports the new recommendation for the use of the GLI-2022.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"831-839"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence Moving Into Respiratory Medicine.","authors":"David C L Lam","doi":"10.1111/resp.70093","DOIUrl":"10.1111/resp.70093","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"893-894"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lessons Learned From International Lung Cancer Screening Trials; People at Risk Deserve Screening for Early Detection.","authors":"Emily Stone, Henry Marshall, Pan-Chyr Yang, Kwun M Fong","doi":"10.1111/resp.70097","DOIUrl":"10.1111/resp.70097","url":null,"abstract":"<p><p>In the modern era, the role of lung cancer screening by low dose computed tomography (CT) is now broadly accepted, with many jurisdictions offering or intending to offer population-based screening based on high quality randomised controlled trial (RCT) evidence. Optimal implementation will be crucial to ensure sufficiently high participation rates in efficient quality assured lung cancer screening programmes (LCSPs) to achieve the gains predicted by modelling and health technology assessments. Performed well, LCSPs can be anticipated to complement the reduction in lung cancer burden already realised from the introduction of molecularly targeted agents and immune checkpoint inhibitors for advanced stage lung cancer. In this review, we will describe the recent clinical developments from published trials to highlight contemporaneous lung cancer screening (LCS) issues and discuss potential enablers and barriers to the effective implementation of LCSP commonly encountered across the world, particularly from the viewpoint of the Asia Pacific region and peoples.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"802-816"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12438035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter From The Philippines-Breathing Life Into the Nation: The Philippine College of Chest Physicians and Its Impact on Respiratory Health.","authors":"Guinevere Dy Agra","doi":"10.1111/resp.70110","DOIUrl":"10.1111/resp.70110","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"899-901"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Single Nucleotide Polymorphisms and Disease Susceptibility, Survival, and Acute Exacerbation in Idiopathic Pulmonary Fibrosis.","authors":"Kazuya Tsubouchi, Toyoshi Yanagihara, Fumiaki Kiyomi, Yuzo Yamamoto, Masako Arimura-Omori, Naoki Hamada, Katsuyuki Ichiki, Shohei Takata, Hiroshi Ishii, Yasuhiko Kitasato, Masaki Okamoto, Satoru Kawakami, Kazuhiro Yatera, Masayuki Kawasaki, Masaki Fujita, Shoji Tokunaga, Chikako Kiyohara, Yoichi Nakanishi, Isamu Okamoto","doi":"10.1111/resp.70120","DOIUrl":"https://doi.org/10.1111/resp.70120","url":null,"abstract":"<p><strong>Background and objective: </strong>Genetic polymorphisms have been associated with susceptibility to interstitial lung diseases including idiopathic pulmonary fibrosis (IPF). We have now examined the relation between single nucleotide polymorphisms (SNPs) and clinical course, including acute exacerbation (AE), in addition to disease susceptibility for IPF and unclassifiable idiopathic interstitial pneumonias (IIPs).</p><p><strong>Methods: </strong>DNA samples were collected from 223 IPF patients and 160 unclassifiable IIP patients included in a prospective, multicentre observational study in Japan. Nonfibrotic control subjects (n = 379) were selected from a previous study. Genotyping of TERT rs2736100, TERC rs1881984, MUC5B rs35705950, DSP rs2076295, and AKAP13 rs62025270 was conducted with commercial assays. The association between these SNPs and disease susceptibility, prognosis, or the cumulative incidence of AE was assessed.</p><p><strong>Results: </strong>TERT rs2736100 and MUC5B rs35705950 were significantly associated with IPF risk, and DSP rs2076295 was linked to prognosis and the incidence of AE in IPF patients. TERT rs2736100 was significantly associated with prognosis in IPF patients and the incidence of AE in patients with unclassifiable IIPs. No individuals with the TT genotype of MUC5B rs35705950 were identified, and the proportion of those with the T allele was low (minor allele frequency of 0.005 in control subjects). In addition, no individuals with the minor allele (A) of AKAP13 rs62025270 were detected.</p><p><strong>Conclusion: </strong>Consideration of genetic polymorphisms has the potential to facilitate prediction not only of prognosis but also of AE in individuals with IIPs, providing a foundation for the development of personalised management strategies based on genetic profiles.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Airway-To-Vessel Volume Ratio and Visual Bronchiectasis Are Associated With Exacerbations in COPD.","authors":"Nobuyasu Wakazono, Kaoruko Shimizu, Naoya Tanabe, Akira Oguma, Hironi Makita, Kazufumi Okada, Miho Wakazono, Hiroki Nishimura, Yuichi Kojima, Michiko Takimoto-Sato, Munehiro Matsumoto, Yuki Abe, Ayako Igarashi-Sugimoto, Nozomu Takei, Hirokazu Kimura, Houman Goudarzi, Takeshi Hattori, Ichizo Tsujino, Susumu Sato, Shigeo Muro, Masaharu Nishimura, Toyohiro Hirai, Satoshi Konno","doi":"10.1111/resp.70114","DOIUrl":"https://doi.org/10.1111/resp.70114","url":null,"abstract":"<p><strong>Background and objective: </strong>The effects of the volume mismatch between the airway and lung vasculature on exacerbation in chronic obstructive pulmonary disease (COPD) is uncertain. We aimed to examine the association between an increased volume ratio of the airway to lung blood vessels (AVR) and exacerbations, regardless of visually assessed bronchiectasis (modified Reiff [mReiff] score) and extrapulmonary vasculature on computed tomography (CT), in patients with COPD during a 5-year follow-up period.</p><p><strong>Methods: </strong>Participants were recruited from the Hokkaido COPD Cohort Study (original, N = 96) and Kyoto University cohort (validation, N = 130). CT-derived indices of the airway and vasculature, mReiff scores, and ratio of pulmonary artery diameter to aorta diameter (PA/Ao) were evaluated. The Kaplan-Meier method with log-rank tests was used to compare the high (highest quartile) and low (other quartiles) groups, while multivariable Cox proportional hazards models explored the factors associated with the time to first exacerbation.</p><p><strong>Results: </strong>The high AVR group showed a shorter time to first exacerbation than the low AVR group in analyses of both all patients and those without visual bronchiectasis. High AVR was significantly associated with exacerbations [Hazard ratio [95% confidence interval]: original, 3.85 [1.17, 12.6]; validation, 2.01 [1.15, 3.52]), irrespective of mReiff scores and PA/Ao in all patients. The lung-volume-corrected airway or blood vessel volumes did not correlate with the time to first exacerbation.</p><p><strong>Conclusion: </strong>High AVR was associated with a shorter time to first exacerbation, complementary to mReiff score and PA/Ao, suggesting that AVR is a novel CT-derived predictor of exacerbation in COPD.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Outcomes Between Ablation and Lobectomy in Stage IA Non-Small Cell Lung Cancer: A Retrospective Multicenter Study.","authors":"Bingchen Xu, Zhixian Chen, Dengyao Liu, Zhihua Zhu, Fujun Zhang, Letao Lin","doi":"10.1111/resp.70116","DOIUrl":"https://doi.org/10.1111/resp.70116","url":null,"abstract":"<p><strong>Background and objective: </strong>Image-guided thermal ablation (IGTA) has been increasingly used in patients with stage IA non-small cell lung cancer (NSCLC) without surgical contraindications, but its long-term outcomes compared to lobectomy remain unknown. This study aims to evaluate the long-term outcomes of IGTA versus lobectomy and explore which patients may benefit most from ablation.</p><p><strong>Methods: </strong>After propensity score matching, a total of 290 patients with stage IA NSCLC between 2015 and 2023 were included. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method. A Markov model was constructed to evaluate cost-effectiveness. Finally, a radiomics model based on preoperative computed tomography (CT) was developed to perform risk stratification.</p><p><strong>Results: </strong>After matching, the median follow-up intervals were 34.8 months for the lobectomy group and 47.2 months for the ablation group. There were no significant differences between the groups in terms of 5-year PFS (hazard ratio [HR], 1.83; 95% CI, 0.86-3.92; p = 0.118) or OS (HR, 2.44; 95% CI, 0.87-6.63; p = 0.092). In low-income regions, lobectomy was not cost-effective in 99% of simulations. The CT-based radiomics model outperformed the traditional TNM model (AUC, 0.759 vs. 0.650; p < 0.01). Moreover, disease-free survival was significantly lower in the high-risk group than in the low-risk group (p = 0.009).</p><p><strong>Conclusion: </strong>This study comprehensively evaluated IGTA versus lobectomy in terms of survival outcomes, cost-effectiveness, and prognostic prediction. The findings suggest that IGTA may be a safe and feasible alternative to conventional surgery for carefully selected patients.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence Will Boost Repurposing of Registered Compounds for Respiratory and Other Indications.","authors":"Philip G Bardin, Belinda J Thomas, Jane E Bourke","doi":"10.1111/resp.70122","DOIUrl":"https://doi.org/10.1111/resp.70122","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adding Weight to the Evidence: MMP-9 as a Predictor of COPD Development.","authors":"Niki L Reynaert, Didier Cataldo","doi":"10.1111/resp.70119","DOIUrl":"https://doi.org/10.1111/resp.70119","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradable Stents-A New Option for Benign Central Airway Stenosis.","authors":"Oğuz Karcıoğlu, Eda Burcu Boerner, Faustina Funke, Jane Winantea, Filiz Oezkan, Rudiger Karpf-Wissel, Kaid Darwiche","doi":"10.1111/resp.70117","DOIUrl":"https://doi.org/10.1111/resp.70117","url":null,"abstract":"<p><strong>Background and objective: </strong>Patients diagnosed with benign central airway stenosis who are ineligible for surgical intervention require airway stents. The high complication rates associated with conventional silicone and metallic stents have led to the development of new devices with lower complication rates and easier insertion and removal. This paper presents our results, including the indications, patient characteristics, and outcomes.</p><p><strong>Methods: </strong>We reviewed patients who underwent bronchoscopy for airway stenosis due to a benign cause between January 2015 and February 2023 in the interventional pulmonology unit of a tertiary university hospital. The causes and locations of stenosis, outcomes, and complications were analysed in patients who received a minimum of one biodegradable (BD) stent. All procedures were performed under general anaesthesia using a rigid bronchoscope.</p><p><strong>Results: </strong>A total of 136 BD stents were implanted at 22 airway sites in 18 patients, with a median age of 56. Thirteen patients, three with prior metal stents and 10 with prior silicone stents, had a history of non-BD stent usage. Twelve procedures (54.5%) used bronchial stents, whereas 10 procedures (45.4%) used tracheal stents. The median duration of BD stent use was 10.6 months (range: 0.1-72.0 months). Early complications included one moderate granulation formation and two dislocations that necessitated stent fixation: one using clips and the other sutured to an additional stent.</p><p><strong>Conclusion: </strong>The study indicates that BD stents are both safe and feasible for treating benign stenosis, offering a safer alternative to silicone and metallic stents while providing personalised treatment for patients.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}