Respirology最新文献

{"title":"Respiratory Health Impacts of Landscape Fires: Insights Including Reports From East and Southeast Asia.","authors":"Kazuhiro Yatera, Chinatsu Nishida","doi":"10.1111/resp.70090","DOIUrl":"10.1111/resp.70090","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"798-801"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12438012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The High Burden of Asthma Readmission Among Australian Children: A Population-Based Cohort Study.","authors":"Md Mahbubur Rashid, Nan Hu, Jahidur Rahman Khan, Mei Chan, Melinda Gray, Louisa Owens, Adam Jaffe, Nusrat Homaira","doi":"10.1111/resp.70049","DOIUrl":"10.1111/resp.70049","url":null,"abstract":"<p><strong>Background and objective: </strong>Worldwide, up to 40% of all asthma hospitalisations are due to repeat admissions. This study aimed to estimate the burden of asthma readmission among children aged 2 to 17 years in New South Wales (NSW), Australia.</p><p><strong>Methods: </strong>A retrospective longitudinal whole-of-population-based cohort study was conducted using linked administrative data. Children born in NSW from 2005 to 2015 having at least one asthma hospitalisation after the age of 2 years were included in the study and followed up for 12 months from the asthma index hospitalisation. The incidence rates for asthma first readmission within 12 months and associated direct medical costs were calculated.</p><p><strong>Results: </strong>During 2007-2022, 48,217 asthma hospitalisations occurred in children, with 28,177 children hospitalised for asthma as a primary diagnosis identified as asthma index hospitalisations. Among them, 21.6% experienced first asthma readmissions within 12 months, including over 80% from the 2-4 years age group and a significant proportion from socioeconomically disadvantaged areas. The overall incidence rate of first asthma readmission was 23.8 per 100 person-years and 28.7 per 100 person-years for children aged 2-4 years. The highest incidence rate (38.3 per 1000 person-months) occurred within 1 month. The total direct medical cost of the first asthma readmission within 12 months was AU$ 15.6 million.</p><p><strong>Conclusion: </strong>Our study suggests that pre-school children have the highest rate of asthma readmission, with a significant economic burden highlighting the need for identifying modifiable factors such as asthma management after discharge to reduce the burden of asthma hospital readmission in children.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"871-881"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12438009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of a Modified Bronchoscopic Transparenchymal Nodule Access Technique ('Essen Tunnel') for Improving the Diagnosis of Intraparenchymal Pulmonary Lesions.","authors":"Erik Büscher, Faustina Funke, Jane Winantea, Hanna Zellerhoff, Johannes Wienker, Marcel Opitz, Christian Taube, Kaid Darwiche","doi":"10.1111/resp.70053","DOIUrl":"10.1111/resp.70053","url":null,"abstract":"<p><strong>Background and objective: </strong>Diagnosing intraparenchymal pulmonary lesions lacking a bronchus sign remains challenging. Bronchoscopic transparenchymal nodule access (BTPNA) for reaching such lesions has seen limited clinical adoption due to insufficient evidence and practical challenges. This study evaluates the feasibility and diagnostic yield of a modified BTPNA (mBTPNA) technique-referred to as the 'Essen tunnel'-which eliminates the need for a guide sheath.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on patients undergoing virtual bronchoscopic navigation (VBN) incorporating the mBTPNA technique at our centre, from December 2019 to March 2024. The 'Essen tunnel' was created by a needle under virtual navigation guidance, enabling direct insertion of an ultrathin bronchoscope (UTB) or radial endobronchial ultrasound (R-EBUS) probe to biopsy intraparechymal lesions.</p><p><strong>Results: </strong>Among 266 lesions targeted via VBN, 37 (14%) intraparenchymal lesions (mean target length: 12.7 ± 4.1 mm) were accessed using mBTPNA. The tunnel was successfully created in 97.3% of cases with UTB intubation in 51.4%. R-EBUS was inserted into the tunnel in 83.8% of cases. Semicircular to circular patterns (SCP) were detected in 19.4% before and 61.3% after tunnel creation (p < 0.01). SCP presence on R-EBUS following mBTPNA was associated with a diagnostic accuracy of 66.7%, comparable to that observed in non-tunnel lesions exhibiting a bronchus sign (72.9%, p = 0.58). No severe complications were observed.</p><p><strong>Conclusion: </strong>The mBTPNA technique is a feasible and safe method that enhances endosonographic lesion detection and achieves promising diagnostic accuracy for challenging intraparenchymal lesions.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"851-860"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12438015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taking an Effective Occupational History: Challenges and Opportunities in Respiratory Health.","authors":"Ryan F Hoy, Adrienne Edwards","doi":"10.1111/resp.70070","DOIUrl":"10.1111/resp.70070","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"794-795"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of COPD With Cardiovascular Risk in Asia: A Review by the Asian Pacific Society of Respirology COPD Assembly.","authors":"Chin Kook Rhee, Fanny Wai San Ko, Vu Van Giap, Theerasuk Kawamatawong, Jung-Kyu Lee, Kazuto Matsunaga, Helmy Haja Mydin, Yong-Kek Pang, Diahn-Warng Perng, Myla Salazar-Supe, Yoko Shibata, David Sim, Naoya Tanabe, Augustine Tee, Hao-Chien Wang, Yen-Wen Wu, Faisal Yunus","doi":"10.1111/resp.70103","DOIUrl":"10.1111/resp.70103","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) has a high burden in Asia. These patients are also susceptible to various cardiovascular diseases (CVD). A panel of expert Asian pulmonologists explored the published literature to understand the impact of COPD and CVD on each other and to identify the cardiopulmonary risk factors in the region. The experts concluded that an elevated risk of all-cause mortality and acute cardiovascular events persists for up to 2 years following moderate and severe COPD exacerbations, with the risk of death being highest in the first 30 days after the exacerbation. High smoking rate (especially in males), high indoor and outdoor air pollution in Asia, relatively low vaccination rate in Asia (especially in low- and middle-income countries), and relatively low rate of utilisation of inhaler medications impact the cardiopulmonary risk in Asia.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"817-830"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12438046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leading Women in Respiratory Clinical Sciences: Letter From Singapore.","authors":"Charmaine Peizhen Sim","doi":"10.1111/resp.70096","DOIUrl":"10.1111/resp.70096","url":null,"abstract":"<p><p>Special Series: Leading Women in Respiratory Clinical Sciences Series Editors: Anne-Marie Russel and Kathleen O Lindell.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"895-898"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatric Asthma Readmissions in Australia: Is Our Care Good Enough?","authors":"Shivanthan Shanthikumar","doi":"10.1111/resp.70080","DOIUrl":"10.1111/resp.70080","url":null,"abstract":"","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"796-797"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Occupational Exposures and Cough Subclasses Among Middle-Aged Australians.","authors":"Jingwen Zhang, Jennifer L Perret, Dinh S Bui, Sheikh M Alif, Michael J Abramson, Anne B Chang, Hans Kromhout, Garun S Hamilton, Paul S Thomas, Bircan Erbas, Bruce R Thompson, Melanie C Matheson, E Haydn Walters, Caroline J Lodge, Shyamali C Dharmage","doi":"10.1111/resp.70040","DOIUrl":"10.1111/resp.70040","url":null,"abstract":"<p><strong>Background and objective: </strong>The evidence around occupation-related chronic cough is conflicting and current definitions of chronic cough cannot capture its heterogeneity. Using our recently characterised novel cough subclasses, we aimed to identify subclass-specific occupational risks.</p><p><strong>Methods: </strong>Using data from the Tasmanian Longitudinal Health Study (TAHS), occupational exposures up to age 53 years were coded using the ALOHA+ Job Exposure Matrix, into ever-exposure (no, only-low, ever-high) and cumulative exposure. People belonging to six previously identified cough subclasses among 2213 current coughers at age 53 years were compared to non-coughers (n = 1396). Associations with occupational exposures were assessed using multinomial logistic regression for these cough subclasses and logistic regression for standard definitions (chronic cough, chronic phlegm, and chronic bronchitis) after adjusting for potential confounders.</p><p><strong>Results: </strong>Biological dust was associated with \"cough with allergies\" (cumulative: adjusted multinomial odds ratio [aMOR] = 1.06, 95% CI: 1.02-1.10, per 10 exposure-year increase). Aromatic solvents were associated with \"chronic dry cough\" (cumulative: aMOR = 1.15, 95% CI: 1.02-1.29). Other solvents were associated with \"chronic productive cough\" (ever-high: aMOR = 2.81, 95% CI: 1.26-6.2); \"intermittent productive cough\" (cumulative: aMOR = 1.06, 95% CI: 0.98-1.16), chronic bronchitis (ever-high: aOR = 2.48, 95% CI: 1.01-6.06); and chronic phlegm (ever-high: aOR = 2.26, 95% CI: 1.14-4.51). Herbicides (cumulative) were also associated with \"intermittent productive cough\" (aOR = 1.09, 95% CI: 1.00-1.77) and chronic phlegm (aOR = 1.07, 95% CI: 1.00-1.15).</p><p><strong>Conclusion: </strong>Novel cough subclasses had distinct associations with specific occupational exposures, suggesting different pathophysiology. Aromatic solvents were associated with dry cough; biological dust with allergic cough; herbicides and other solvents with productive cough. Using novel cough subclasses was superior to standard definitions in uncovering these associations.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"840-850"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12438006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aetiology of Adult Community-Acquired Lung Abscess in Hong Kong.","authors":"Wai Cho Yu, Man Ying Ho, Ellen Lok-Man Yu, Carmen Li, Cindy Tse, Ka Pang Chan, Pik Shan Cheung, Kit Man Sin, Wai Man Johnny Chan, David Chi Leung Lam, Kah Lin Choo, Chi Kai Chow, Yu Hong Chan, Ming Chiu Chan, Kin Keung Kwong, Margaret Ip","doi":"10.1111/resp.70050","DOIUrl":"10.1111/resp.70050","url":null,"abstract":"<p><strong>Background and objective: </strong>Knowing the Pattern of pathogens in community-acquired lung abscess (CALA) is important in the choice of initial empiric antibiotics. Early studies established the anaerobes as the predominant pathogen, followed by aerobic streptococci and aerobic Gram-negative bacilli. However, recent reports indicated that Klebsiella pneumoniae and aerobic streptococci predominated.</p><p><strong>Methods: </strong>We performed a retrospective study on CALA cases from all public hospitals in Hong Kong over a nine-year period. Only cases with uncontaminated specimens sent for bacterial culture were included. Cases caused by mycobacteria and fungi were excluded.</p><p><strong>Results: </strong>There were 606 eligible subjects-episodes. Mean age of subjects was 57.7 years and male to female ratio was 3.3:1. Two hundred and thirty-two subjects had at least one positive bacterial culture, with a total of 338 pathogens isolated. Anaerobes were the predominant pathogen group with 103 isolates (30.5% of total). This was followed by aerobic streptococci (90, 26.6%), aerobic Gram-negative bacilli (67, 19.8%), and Staphylococcus aureus (56, 16.6%). Isolation of Staphylococcus aureus was closely linked to intravenous drug abuse, while isolation of Klebsiella pneumoniae (28 cases) was related to extrapulmonary abscesses, particularly of the liver. There were 14 cases of Pseudomonas aeruginosa with underlying chronic lung disease and major organ failure being risk factors.</p><p><strong>Conclusion: </strong>Anaerobes and aerobic streptococci appear to be the major pathogens for primary CALA. Secondary lung abscess caused by haematogenous spread is commonly attributable to Staphylococcus aureus or Klebsiella pneumoniae . Choice of empiric antibiotics should take these into consideration together with local patterns of antibiotic resistance.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"882-892"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human and Deep Learning Predictions of Peripheral Lung Cancer Using a 1.3 mm Video Endoscopic Probe.","authors":"Edoardo Amante, Robin Ghyselinck, Luc Thiberville, Rocco Trisolini, Florian Guisier, Valentin Delchevalerie, Bruno Dumas, Benoît Frénay, Inès Duparc, Nicolas Mazellier, Cecile Farhi, Christophe Jubert, Mathieu Salaün, Samy Lachkar","doi":"10.1111/resp.70057","DOIUrl":"10.1111/resp.70057","url":null,"abstract":"<p><strong>Background and objective: </strong>Iriscope, a 1.3 mm video endoscopic probe introduced through an r-EBUS catheter, allows for the direct visualisation of small peripheral pulmonary nodules (PPNs). This study assessed the ability of physicians with different levels of experience in bronchoscopy, and the ability of artificial intelligence (AI) to predict the malignant nature of small PPNs during Iriscope peripheral endoscopy.</p><p><strong>Methods: </strong>Patients undergoing bronchoscopy with r-EBUS and Iriscope for peripheral PPNs < 20 mm with a definite diagnosis were analysed. Senior and Junior physicians independently interpreted video-recorded Iriscope sequences, classifying them as tumoral (malignant) or non-tumoral, blind to the final diagnosis. A deep learning (DL) model was also trained on Iriscope images and tested on a different set of patients for comparison with human interpretation. Diagnostic accuracy, sensitivity, specificity, and F1 score were calculated.</p><p><strong>Results: </strong>Sixty-one patients with small PPNs (median size 15 mm, IQR: 11-20 mm) were included. The technique allowed for the direct visualisation of the lesions in all cases. The final diagnosis was cancer for 37 cases and a benign lesion in 24 cases. Senior physicians outperformed junior physicians in recognising tumoral Iriscope images, with a balanced accuracy of 85.4% versus 66.7%, respectively, when compared with the final diagnosis. The DL model outperformed junior physicians with a balanced accuracy of 71.5% but was not superior to senior physicians.</p><p><strong>Conclusion: </strong>Iriscope could be a valuable tool in PPNs management, especially for experienced operators. Applied to Iriscope images, DL could enhance overall performance of less experienced physicians in diagnosing malignancy.</p>","PeriodicalId":21129,"journal":{"name":"Respirology","volume":" ","pages":"861-870"},"PeriodicalIF":6.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12437996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}