Respiratory medicine最新文献

{"title":"Drug-induced cough risk: A pharmacovigilance study of FDA adverse event reporting system database","authors":"Yang Rui,&nbsp;Tianyuan Xin,&nbsp;Yu Chen,&nbsp;Beiyi Xiang,&nbsp;Changwen Chen,&nbsp;Zhe Chen","doi":"10.1016/j.rmed.2025.108367","DOIUrl":"10.1016/j.rmed.2025.108367","url":null,"abstract":"<div><h3>Background</h3><div>Drug-induced cough is a prevalent adverse drug reaction; however, the risk of cough associated with various drug classes in real-world settings has not been thoroughly elucidated.</div></div><div><h3>Objectives</h3><div>This study aims to systematically identify drug risk signals that are significantly associated with cough through the FAERS database, covering data from the first quarter of 2004 to the fourth quarter of 2024. The findings will provide evidence-based support for clinical medication safety and individualized monitoring.</div></div><div><h3>Methods</h3><div>We extracted reports in which cough was identified as the primary adverse event (AE) from the FAERS database. After data cleaning to exclude duplicate and non-drug-related records, use the Reporting Odds Ratio (ROR) and Proportional Reporting Ratio (PRR) for disproportionality analysis. Standardize the Preferred Term (PT) for cough using MedDRA 27.1. Additionally, classify each drug using the World Health Organization's Anatomical Therapeutic Chemical (ATC) classification system.</div></div><div><h3>Results</h3><div>This study identified 1951 drugs associated with the AE of \"cough,\" affecting a total of 247,158 patients. The drug categories most commonly linked to cough included antineoplastic and immunomodulating agents, respiratory system medications, and cardiovascular system medications. The drugs (primary suspect) with the highest number of reported cough cases were adalimumab, etanercept, and sacubitril/valsartan.</div></div><div><h3>Conclusion</h3><div>This study is the first to systematically reveal the strength of association and baseline characteristics between multiple categories of drugs and the risk of cough, confirming the high efficiency and sensitivity of the FAERS database in pharmacovigilance. The findings of this study provide an important basis for drug risk assessment and clinical intervention.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108367"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of neuromuscular electrical stimulation on exercise capacity, muscle strength, physical activity, and quality of life in patients with interstitial lung diseases: A randomized study","authors":"Burcu Camcıoğlu Yılmaz ,&nbsp;Meral Boşnak Güçlü ,&nbsp;Müşerrefe Nur Keleş ,&nbsp;Deran Oskay ,&nbsp;Haluk Türktaş","doi":"10.1016/j.rmed.2025.108360","DOIUrl":"10.1016/j.rmed.2025.108360","url":null,"abstract":"<div><h3>Background</h3><div>Neuromuscular electrical stimulation (NMES) has been investigated for various cardiopulmonary conditions; however, its effects on interstitial lung disease (ILD) remain poorly understood.</div></div><div><h3>Objective</h3><div>To investigate the effects of NMES on exercise capacity, muscle strength, quality of life, and physical activity in ILD patients.</div></div><div><h3>Methods</h3><div>This was a prospective, randomized, controlled, triple-blinded study. Nineteen patients in the NMES group received NMES on the bilateral quadriceps femoris (QF) at 40 Hz for 20 min, three times a week for six weeks, along with daily respiratory exercises. Eighteen patients in the control group performed respiratory exercises alone for six weeks. Outcomes measured before and after included: 6-min walk test (6MWT), incremental shuttle walk test (ISWT), maximum inspiratory and expiratory pressures (MIP, MEP), QF muscle strength, quality of life (SGRQ, LCQ), physical activity, dyspnea (MMRC scale), and fatigue (FSS).</div></div><div><h3>Results</h3><div>The NMES group demonstrated significant improvements in 6MWT distance, MMRC, energy expenditure, physical activity duration, and daily step count, with increased FSS scores compared to the control group (p = 0.025). No significant differences were observed between groups for ISWT, MIP/MEP, SGRQ, or LCQ scores (p &gt; 0.05). While 6MWT distance improved (p = 0.002), QF muscle strength was preserved within the NMES group but decreased within the control group (p = 0.018).</div></div><div><h3>Conclusion</h3><div>NMES is a feasible and effective intervention for enhancing exercise capacity and physical activity levels, while preserving muscle strength and reducing dyspnea in patients with ILD. This implies that incorporating NMES into the rehabilitation programs of ILD patients may enhance their overall physical performance and quality of life.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108360"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145099505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasopharyngeal airway relieves upper airway obstruction to alleviate hypoxemia during painless gastrointestinal endoscopy for obese outpatients: a prospective randomized controlled trial","authors":"Yanhua Peng ,&nbsp;Lei Deng ,&nbsp;Shiyu Dai ,&nbsp;Dongmei Xiang ,&nbsp;Rui Zhou ,&nbsp;Xianjie Zhang ,&nbsp;Lei Tian ,&nbsp;Yukai Zhou ,&nbsp;Wenya Chen ,&nbsp;Jun Zhou","doi":"10.1016/j.rmed.2025.108359","DOIUrl":"10.1016/j.rmed.2025.108359","url":null,"abstract":"<div><h3>Purposes</h3><div>To investigate the efficacy of nasopharyngeal airway intubation in alleviating hypoxemia in obese outpatients undergoing painless gastrointestinal endoscopy.</div></div><div><h3>Methods</h3><div>This prospective single-center randomized controlled trial was conducted at the Deyang People's Hospital, Deyang, China. Obese outpatients scheduled for painless gastrointestinal endoscopy were randomly assigned to either the nasopharyngeal airway (Group N) or control group (Group C). Nasopharyngeal airway intubation was performed prior to the examination. The primary outcome was the incidence of hypoxemia, while secondary outcomes included intubation duration, procedural interruptions due to desaturation, security events, visual analog scale (VAS) scores, satisfaction scores, and device placement metrics.</div></div><div><h3>Results</h3><div>A total of 88 patients in Group N and 86 patients in Group C were analyzed. The incidence of hypoxemia was 2.27 % in Group N compared to 37.21 % in Group C (<em>P</em> &lt; 0.001). Post-endoscopy, pulse oxygen saturation in Group C was significantly lower than in Group N (<em>P</em> = 0.001). Vital signs showed no differences at the time of intubation and extubation (<em>P</em> &gt; 0.05). Satisfaction scores for endoscopists and anesthesiologists were higher in Group N than in Group C, with scores of 9.97 ± 0.18 vs. 9.73 ± 0.82 (<em>P</em> = 0.01) and 9.89 ± 0.47 vs. 9.10 ± 1.15 (<em>P</em> &lt; 0.001), respectively. In Group N, 87 patients received nasopharyngeal airway intubation, with 69 intubations completed within 5 s, 18 within 10 s, and one patient requiring two attempts within 15 s. In Group N, the VAS score for all patients was ≤3.</div></div><div><h3>Conclusions</h3><div>Prophylactic nasopharyngeal airway intubation effectively alleviates hypoxemia in obese outpatients undergoing painless gastrointestinal endoscopy without increasing side effects. This cost-effective intervention offers a superior strategy for managing hypoxemia in this patient population.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108359"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatable traits in interstitial lung disease: opportunities and challenges","authors":"Yet H. Khor ,&nbsp;Anna J. Podolanczuk ,&nbsp;Elisabetta A. Renzoni ,&nbsp;Vanessa M. McDonald ,&nbsp;Vincent Cottin ,&nbsp;Anne E. Holland ,&nbsp;Yoshikazu Inoue ,&nbsp;Anne Marie Russell ,&nbsp;Jin Woo Song ,&nbsp;Marlies Wijsenbeek ,&nbsp;Mary E. Strek ,&nbsp;Christopher J. Ryerson","doi":"10.1016/j.rmed.2025.108353","DOIUrl":"10.1016/j.rmed.2025.108353","url":null,"abstract":"<div><div>Despite recent advances in disease-targeted pharmacotherapies for interstitial lung disease (ILD), disease progression occurs in a significant proportion of patients with consequent impact on health-related quality of life. Patients with ILD and their caregivers, clinicians, and researchers have expressed the need for more comprehensive care in ILD. The treatable traits approach is proposed as a person-centred framework for management of ILD, delivering the right treatment to the right patient at the right time, targeting distinct traits that affect health outcomes beyond the lung disease itself. These treatable traits can be subdivided into aetiological, pulmonary, extra-pulmonary, and behavioural and lifestyle domains, with multiple opportunities for treatment within each domain. In this review, we highlight opportunities to integrate the treatable traits approach into the existing ILD care throughout the patient journey, taking into account the changing treatment goals at different disease stages. We further highlight the next steps that are required to validate and further develop the treatable traits approach, with the ultimate aim to improve health outcomes for patients with ILD.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108353"},"PeriodicalIF":3.1,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonographic assessment of the airway to evaluate for obstructive sleep apnea – a systematic review and meta-analysis","authors":"Nipun Malhotra ,&nbsp;Yash Kedia ,&nbsp;Akhil Dhanesh Goel ,&nbsp;Sumita Agrawal ,&nbsp;Nitesh Gupta","doi":"10.1016/j.rmed.2025.108355","DOIUrl":"10.1016/j.rmed.2025.108355","url":null,"abstract":"<div><h3>Background</h3><div>Ultrasound (US) has gained attention as a bedside screening tool for obstructive sleep apnea (OSA), with studies evaluating various parameters for its assessment. We conducted this systematic review and meta-analysis to determine whether US assessment of the airway can differentiate between OSA and Non-OSA individuals.</div></div><div><h3>Methods</h3><div>PubMed, Scopus, <span><span>clinicaltrials.gov</span><svg><path></path></svg></span>, GoogleScholar and Embase databases were searched from inception through July 01, 2024 for studies reporting neck ultrasonography in OSA, diagnosed using polysomnography. 1703 studies were identified, and after removing duplicate studies, 798 studies were screened. 23 prospective, cross sectional and case control studies evaluating US parameters for OSA screening were evaluated in the systematic review and 12 studies were included in the quantitative analysis. Weighted mean differences were calculated for various US parameters between OSA and non-OSA groups.</div></div><div><h3>Results</h3><div>Of the 1703 references reviewed, 23 articles were included in the systematic review and 12 underwent quantitative analysis. 11 of the 12 studies were found to be of high quality using Newcastle-Ottawa scale. Significant heterogeneity was observed across studies, with multiple US parameters assessed for OSA screening. We included three static and two dynamic parameters in the meta-analysis; and calculated mean weighted difference (WMD) in dimensions between OSA and non-OSA individuals. The static parameters that significantly differentiated OSA and non-OSA individuals were distance between lingual arteries (WMD 4.43 ± 3.05 mm), mean base of tongue thickness (WMD 6.34 ± 4.86 mm), and lateral pharyngeal wall thickness (WMD 3.59 ± 1.99 mm); while the dynamic parameters included retropalatal diameter during inspiration (WMD -9.41 ± 6.16 mm), expiration (WMD -6.10 ± 2.61 mm) and muller's maneuver (WMD -10.49 ± 7.31 mm); and retroglossal diameter during inspiration (WMD -3.84 ± 1.46 mm) and expiration (WMD -2.27 ± 1.39 mm).</div></div><div><h3>Conclusions</h3><div>Increased distance between the lingual arteries, greater mean tongue base thickness, and thicker lateral pharyngeal walls; or reduced retropalatal diameter during inspiration, expiration, or Muller's maneuver; or reduced retroglossal diameter during inspiration or expiration were consistently able to differentiate individuals with OSA from non-OSA individuals. However, standardized cutoff values are not yet available, underscoring the need for larger, methodologically uniform studies before routine clinical application can be recommended.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108355"},"PeriodicalIF":3.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmasking obstructive sleep apnea: Estimated prevalence and impact in the United States","authors":"Ibrahim Sönmez ,&nbsp;Alexandre Vo Dupuy ,&nbsp;Kristina S. Yu ,&nbsp;John Cronin ,&nbsp;John Yee ,&nbsp;Ali Azarbarzin","doi":"10.1016/j.rmed.2025.108348","DOIUrl":"10.1016/j.rmed.2025.108348","url":null,"abstract":"<div><h3>Background</h3><div>Obstructive sleep apnea (OSA) is a serious chronic disease, characterized by repeated upper airway obstructions during sleep, leading to episodes of disrupted breathing, sleep fragmentation, and reduced oxygen saturation. Adjusting for obesity as a major risk factor, we aimed to provide a contemporary estimate of the OSA prevalence in the United States (US).</div></div><div><h3>Methods</h3><div>A literature-based systematic review was conducted to identify studies of OSA prevalence in adults using the AHI₄ criteria (all apneas plus hypopneas associated with ≥4% oxygen desaturation). OSA was defined as having an AHI₄ ≥ 5 events/hr. For total prevalence, age-, and gender-specific rates were estimated based on eligible studies and the base-year estimation for 2004 was calculated. The obesity population attributable fraction was applied to base-year estimates to project OSA prevalence in year 2024. The AHI₄ distribution of mild (5-&lt;15), moderate (15-&lt;30) and severe (≥30 events/hr) OSA was also estimated.</div></div><div><h3>Results</h3><div>A total of 83.7 million adults (aged 20 years and older) were estimated to be living with OSA in the US in 2024, of whom 49,459,041 (59%) were males and 34,257,378 (41%) females. This translates to 32.4% overall prevalence in the US among adults aged 20 years and older, with 39.1% among males and 26.0% in females, adjusting for obesity. The distribution of OSA severity was estimated to be 52% mild, 30% moderate, and 18% severe.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that OSA is highly prevalent among US adults. Despite its substantial prevalence, OSA remains largely undiagnosed, highlighting the urgent need for improved screening and diagnosis.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108348"},"PeriodicalIF":3.1,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to the Chronic Obstructive Pulmonary Disease guidelines in primary care: The Greek COPD COCARE study","authors":"Ioanna Tsiligianni ,&nbsp;Stavroula Papageorgakopoulou ,&nbsp;Izolde Bouloukaki","doi":"10.1016/j.rmed.2025.108345","DOIUrl":"10.1016/j.rmed.2025.108345","url":null,"abstract":"<div><h3>Purpose</h3><div>Although adherence to COPD guidelines among general practitioners (GPs) is essential for providing effective patient care, research indicates significant variation in their implementation. We aimed to evaluate adherence to COPD guidelines in primary care in Greece and explore opportunities for improvement.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted in eight primary care practices in Crete, Greece with 10 GPs participating. Patients identified by GPs with COPD diagnosis were included. Clinical performance vs current guidelines was categorized into levels of appropriateness: excellent (&gt;80 %), good (60–80 %), adequate (40–59 %), inadequate (20–39 %), and very inadequate (&lt;20 %).</div></div><div><h3>Results</h3><div>253 clinical records were reviewed. Adherence to guideline statements presented an excellent/good adherence for smoking (94 %), vaccination (93–96 %), exacerbations (72 %) and co-morbidities recording (87 %) and further workup with chest X-ray or CT (71 %). However, guideline-concordant prescriptions for inhaled therapies were documented in only 34 % of the patient population. The most outstanding areas for improvement included evaluating COPD risk factors beyond smoking (14 %), measuring alpha1-antitrypsin levels (2 %), monitoring treatment adherence (12 %), referring patients to pulmonary rehabilitation (8 %), considering eosinophil counts for treatment initiation (10 %), developing written self-management plans (10 %), and assessing non-prescribed medications (19 %). Guideline adherence varied substantially between rural and urban settings across several key areas.</div></div><div><h3>Conclusion</h3><div>Our results show that adherence to COPD guidelines among GPs is suboptimal and varies between rural and urban settings. Such information must be accounted for by health care professionals and administrators in primary care, to improve strategies and establish better clinical practices.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108345"},"PeriodicalIF":3.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of sampling method on the success of tissue diagnosis and molecular profiling in ultrasound guided biopsies for lung cancer","authors":"Maged Hassan ,&nbsp;Muhammad Aamir Anees ,&nbsp;Tousif Baig ,&nbsp;Sarah Nicholson","doi":"10.1016/j.rmed.2025.108352","DOIUrl":"10.1016/j.rmed.2025.108352","url":null,"abstract":"<div><h3>Background and aims</h3><div>In lung cancer diagnosis tissue should be adequate for identification of tumour type, and for testing for molecular alterations including multi-target next generation sequencing (NGS) where resources allow. This study aimed to examine the sufficiency of percutaneous ultrasound (US) guided samples obtained via the 2 main sampling methods; fine needle aspiration (FNA) and core biopsy (CB) for different levels of lung cancer testing.</div></div><div><h3>Methods</h3><div>Details of US-guided procedures carried out for lung cancer diagnosis were retrospectively collected. FNA and/or CBs were carried out according to feasibility and on-site cytology was not available. Diagnostic yields for histological diagnosis, limited molecular panel and multi-target NGS panel were calculated for each procedure.</div></div><div><h3>Results</h3><div>Out of 66 samples, the yield for identifying tissue type was 95.4 % with no difference in yield between FNA and CBs (92.7 % and 93.6 % respectively). 32 samples were sent for multi-target NGS, with a success rate of 71.9 %. This was improved from 66.7 % to 76.5 % when both sampling methods were done as opposed to either method alone.</div></div><div><h3>Conclusion</h3><div>US-guided biopsies have high yield for tissue diagnosis in lung cancer and reasonable adequacy for extended genomic profiling. The results suggest that carrying out both FNA and CB improves the overall yield. Further prospective studies with standardized protocols are needed to confirm these findings.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108352"},"PeriodicalIF":3.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Liuzijue Qigong combined with conventional respiratory rehabilitation after thoracoscopic pulmonary nodule resection: A randomized clinical trial","authors":"Ru-qi Xie ,&nbsp;Xin Zhang","doi":"10.1016/j.rmed.2025.108349","DOIUrl":"10.1016/j.rmed.2025.108349","url":null,"abstract":"<div><h3>Background</h3><div>To investigate the effect of Liuzijue Qigong on pulmonary function, respiratory distress and quality of life in patients after thoracoscopic pulmonary nodule resection.</div></div><div><h3>Methods</h3><div>Fifty-six patients who underwent pulmonary nodule resection in the Nanping First Hospital affiliated to Fujian Medical University from January 2023 to June 2024 were selected. According to the random number table method, they were divided into the intervention group (n = 20) and the control group (n = 20) with a ratio of 1:1. Patients began respiratory rehabilitation and Liuzijue training within 48 h postoperatively. The control group was given routine respiratory rehabilitation training, and the intervention group was given modified sitting Liuzijue training on the basis of routine respiratory rehabilitation training. The treatment time of the two groups was 1 week. The Tidal volume (VT), Forced expiratory volume in 1 s (FEV1), FEV1/FVC, Maximal voluntary ventilation (MVV), 36-Item Short Form Survey (SF-36), and St. George respiratory questionnaire (SGRQ) were compared between the two groups before and after treatment.</div></div><div><h3>Results</h3><div>After treatment, VT, FEV1 and MVV in the intervention group decreased less than those in the control group (<em>P</em> &lt; 0.05). The SF-36 and SGRQ scores of the intervention group were significantly better than those of the control group (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>The results of this study show that Liuzijue Qigong as an auxiliary respiratory rehabilitation therapy can significantly reduce the pulmonary dysfunction of patients after thoracoscopic pulmonary nodule resection, and improve the ability of daily living and quality of life of patients. This study provides a new clinical treatment idea for enhanced recovery after surgery.</div><div>This trial was registered at the Chinese Clinical Trial Registry (<span><span>www.chictr.org.cn</span><svg><path></path></svg></span>) (trial registration number ChiCTR2400093856).</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108349"},"PeriodicalIF":3.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between chronic airflow limitation, respiratory symptoms, and quality of life across alcohol use categories: a population based study","authors":"Line Bjerrehave Nielsen ,&nbsp;Max Olsson ,&nbsp;Ulla Møller Weinreich ,&nbsp;Magnus Ekström","doi":"10.1016/j.rmed.2025.108350","DOIUrl":"10.1016/j.rmed.2025.108350","url":null,"abstract":"<div><h3>Introduction</h3><div>Alcohol use has significant health implications, yet the association between alcohol use and respiratory symptoms remains relatively understudied. This study examines the prevalence of hazardous alcohol use and its associations with breathlessness, chronic cough, and health-related quality of life (HRQoL) and whether these associations with chronic airway limitation (CAL) differ by alcohol use.</div></div><div><h3>Methods</h3><div>Cross-sectional study of the Swedish CArdioPulmonary bioImage Study (SCAPIS) comprising 25,424 aged 50–64. Hazardous alcohol use was defined as an Alcohol Use Disorders Identification Test (AUDIT) score ≥8. CAL was defined as a post-bronchodilator FEV1/FVC ratio &lt;0.7. Breathlessness (mMRC rating ≥2), chronic cough, and HRQoL, measured using the Short Form 12 (SF-12) were assessed through questionnaires. Associations were analysed using multivariable regression models adjusted for smoking, BMI, age, sex, comorbidities, and predicted FEV1/FVC %. In secondary analyses, associations between CAL and outcomes were examined stratified by alcohol use.</div></div><div><h3>Results</h3><div>Hazardous alcohol use was present in 11 % of the analytic sample and in 15 % of those with CAL. Hazardous alcohol use was associated with increased odds of breathlessness (odds ratio [OR] 1.37; [95 % confidence interval] 1.09–1.70) and chronic cough (OR 1.46; 1.32–1.62), and with lower physical and mental HRQoL scores. CAL was more strongly associated with symptoms in participants with hazardous alcohol use than in lower-level users.</div></div><div><h3>Conclusion</h3><div>Hazardous alcohol use was linked to increased breathlessness, chronic cough, and lower HRQoL. Associations between CAL and respiratory symptoms were stronger among individuals with hazardous alcohol use, suggesting a potential interaction.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108350"},"PeriodicalIF":3.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}