Respiratory medicine最新文献

{"title":"Real-world outcomes after initiation of Elexacaftor/tezacaftor/ivacaftor in an adolescent cohort with cystic fibrosis.","authors":"James Johnston, Martin Donnelley, Ronan Smith, Jennie Louise, Jodi Grunert, Carol La Vanda, Andrew Tai","doi":"10.1016/j.rmed.2025.108410","DOIUrl":"https://doi.org/10.1016/j.rmed.2025.108410","url":null,"abstract":"<p><strong>Background: </strong>This study assessed the real-world clinical outcomes and adherence to Elexacaftor/tezacaftor/ivacaftor (ETI) in adolescents with cystic fibrosis (CF).</p><p><strong>Methods: </strong>A retrospective cohort study was conducted in patients aged 12 to 18 years at a tertiary pediatric hospital in Adelaide, Australia. Demographic data include age, CF genotype, and prior use of modulator therapy. Primary outcome measures were percent predicted FEV1 (ppFEV1), body mass index (BMI), and BMI-for-age (BMI z-score). Secondary outcome measures included hospital admissions for pulmonary exacerbations, CF pathogens in sputum, elevated transaminase levels, and medication adherence (MPR) for ETI and dornase alfa.</p><p><strong>Results: </strong>42 patients (median age 15.29 years) were assessed over 12 months of ETI therapy. ppFEV1 increased by 4.1% (95% CI: 1.2, 7.0; p<0.001) in the cohort, with improvements in both homozygous (3.6%) and heterozygous (4.9%) subgroups. BMI increased by 1.0 kg/m² (95% CI: 0.5, 1.5; p<0.001), but no significant change in BMI z-score was observed (mean change 0.0, 95% CI -0.1,0.2). There was a 60% reduction in pulmonary exacerbations requiring hospital admission (rate ratio 0.4; p<0.001) and a 40% reduction in CF pathogens (rate ratio 0.6; p=0.004). Adherence (MPR) was 92.2% for ETI and 13.2% for dornase alfa.</p><p><strong>Conclusions: </strong>This study demonstrated modest improvement in ppFEV1 and BMI compared to previous large studies. There was a decrease in pulmonary exacerbations and number of CF pathogens. ETI adherence was high, while dornase alfa adherence was low. These results highlight the importance of further real-world studies in CF, including methods of measuring and improving adherence to therapies.</p>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"108410"},"PeriodicalIF":3.1,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride-to-High-Density Lipoprotein Ratio as a Predictor of 28-Day Mortality Risk in Patients with Sepsis: A Retrospective Cohort Study.","authors":"Xiaorong Dong, Bei Zhang, Li Ma, Xuefeng Liu, Xiaojuan Zheng, Xiaoxuan Ma","doi":"10.1016/j.rmed.2025.108419","DOIUrl":"https://doi.org/10.1016/j.rmed.2025.108419","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between the triglyceride-to-high-density lipoprotein ratio (TG/HDL) and 28-day mortality in patients with sepsis, and to provide a new indicator and basis for the prognosis evaluation of patients with sepsis.</p><p><strong>Materials and methods: </strong>A retrospective cohort study was conducted that included 578 patients who met the Sepsis 3.0 criteria. Data collection encompassed demographic information, vital signs, laboratory test results, comorbidities, treatment interventions, and prognostic outcomes. The TG/HDL measurement was taken within 24 hours of ICU admission. Patients were categorized into a survival group and a 28-day non-survival group. Additionally, they were stratified into quartiles (Q1, Q2, Q3, Q4) based on their TG/HDL levels. A range of statistical methods were employed for data processing and analysis, including t-tests, non-parametric tests, χ2 tests, logistic regression analysis, subgroup analysis, Kaplan-Meier survival curve analysis, and nonlinear regression analysis.</p><p><strong>Results: </strong>Significant differences were observed between the 28-day mortality and survival groups in age, heart rate, and respiratory rate. TG/HDL quartile analysis showed group differences in multiple parameters and 28-day mortality. Logistic regression indicated that, relative to Q1, Q4 had a significantly elevated 28-day mortality risk (Model 1: OR=3.434, P<0.001; Model 2: OR=4.655, P<0.001; Model 3: OR=2.690, P=0.004), while Q2 and Q3 did not. Subgroup analysis revealed that the TG/HDL-mortality association varied by subgroup. The KM survival curve showed lower Q4 survival, and nonlinear regression confirmed a nonlinear TG/HDL-mortality relationship.</p><p><strong>Conclusion: </strong>TG/HDL ratio can serve as an independent predict of 28-day mortality. Its nonlinearity and subgroup-specific significance offer crucial insights for clinical prognostic stratification.</p>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"108419"},"PeriodicalIF":3.1,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive overview of ventilation intensity and mutual relationship with mechanical power, strain and ventilatory ratio.","authors":"Lorenzo Schiavoni, Alessia Mattei, Alessandro Ruggiero, Alessandro Strumia","doi":"10.1016/j.rmed.2025.108413","DOIUrl":"https://doi.org/10.1016/j.rmed.2025.108413","url":null,"abstract":"<p><p>Ventilator-induced lung injury (VILI) is a concept developed over the past fifty years, highlighting how aggressive ventilatory settings can contribute to lung damage. This study examines the factors inducing lung injury, such as barotrauma, volutrauma, atelectrauma, and biotrauma. Recent guidelines emphasize the importance of low tidal volume and low driving pressure settings to improve outcomes in ARDS patients and nowadays scientific community is still exploring its effectiveness in other settings. The concept of Ventilation Intensity (VI) is introduced as a new approach, distinct from ventilator intensity, representing the total energy delivered during assisted ventilation. VI is related to the mechanical power (MP) of the respiratory system, which includes dynamic and static elastance, resistance, and respiratory rate, expressed in Joules/minute.. VI should be related also to stress and strain, because of lung compliance is a determinant of parenchymal energy absorption during invasive mechanical ventilation, and ventilatory ratio should be considered as a determinant of ventilatory approach and consequently its intensity. At present, VI has not been explored in patients in spontaneous/assisted breathing, and we could just hypothesize that patients drive and efforts could increase VI trough MP and promote patient self-induced lung injury (P-SILI). Additionally, the importance of monitoring VI is discussed to prevent ventilatory aggressiveness and improve outcomes in mechanically ventilated patients. This short review focuses on actual knowledge of VI and plausible correlation with MP, stress, strain and ventilatory ratio to improve its understanding and the potential relationship with VILI and P-SILI.</p>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"108413"},"PeriodicalIF":3.1,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of the prevalence of chronic respiratory diseases and mortality with blood furan levels: a population-based study.","authors":"Shuwen Zhang, Kunlu Shen, Bingqing Sun, Bowen Liu, Chunxiao Li, Mengqi Zhou, Xin Hou, Min Xiang, Jiangtao Lin","doi":"10.1016/j.rmed.2025.108422","DOIUrl":"https://doi.org/10.1016/j.rmed.2025.108422","url":null,"abstract":"<p><strong>Background: </strong>Few studies have explored the role of furan exposure plays in chronic respiratory diseases and mortality.</p><p><strong>Objective: </strong>To access the relationship of furan exposure to chronic respiratory diseases and mortality.</p><p><strong>Methods: </strong>This study involves 5,261 adults over 20 years old from the National Health and Nutrition Examination Survey (NHANES) 2007-2012. Blood furan levels were employed to quantify furan exposure. Multinomial survey-weighted regressions were utilized to analyze the associations between furan exposure and the prevalence of asthma alone, COPD alone, and ACO. Multiple Cox regression was employed to evaluate the association between furan exposure and all-cause and respiratory mortality.</p><p><strong>Results: </strong>After adjusting for covariates, log10-transformed blood furan levels (LBFL) were independently associated with an increased risk of the prevalence of asthma alone, COPD alone, and ACO (aOR = 2.086, 95% CI = 1.005 - 4.332, P = 0.049; aOR = 6.503, 95% CI = 3.471 - 12.185, P < 0.001; aOR = 10.739, 95% CI = 2.250 - 51.246, P = 0.003). For every one-unit increase in the LBFL, the odds of asthma were 1.086 higher, COPD were 5.503 higher, ACO were 9.739 higher. Longitudinally, LBFL were positively correlated with all-cause and respiratory mortality (HR = 1.997, 95% CI = 1.015 - 3.931, P = 0.045; HR = 4.979, 95% CI = 1.053 - 23.541, P = 0.043).</p><p><strong>Conclusions: </strong>Exposure to furan revealed a positive association with greater odds of asthma, COPD, and ACO. An elevated blood furan also is associated with increased all-cause and respiratory mortality.</p>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"108422"},"PeriodicalIF":3.1,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Dyspnea-related kinesiophobia as a barrier on cystic fibrosis: The role of children and parents\"[Respirat. Med. 248 (2025) 108364].","authors":"Vildan Fidanoglu, Zeynep Selcuk, Seda Saka, Erkan Cakir","doi":"10.1016/j.rmed.2025.108418","DOIUrl":"https://doi.org/10.1016/j.rmed.2025.108418","url":null,"abstract":"","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"108418"},"PeriodicalIF":3.1,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between hs-CRP-triglyceride glucose index and obstructive sleep apnea: a study from NHANES 2015–2018","authors":"Simin Yang ,&nbsp;Xinwei Su","doi":"10.1016/j.rmed.2025.108412","DOIUrl":"10.1016/j.rmed.2025.108412","url":null,"abstract":"<div><h3>Background</h3><div>High-sensitivity C-reactive protein-triglyceride glucose index (CTI) has demonstrated superior clinical utility as a dual-parameter indicator integrating both insulin resistance (IR) and systemic inflammatory status. However, the association between CTI and the risk of obstructive sleep apnea (OSA) remains unclear. Therefore, this study aimed to investigate this association utilizing data from the National Health and Nutrition Examination Survey (NHANES) database.</div></div><div><h3>Methods</h3><div>The analysis was based on data from the 2015–2018 NHANES. Multivariate logistic regression analyses were used to investigate the association between CTI and OSA, with additional exploration of the consistency of the results through restricted cubic spline (RCS) regression, receiver operating characteristic (ROC), and subgroup analyses.</div></div><div><h3>Results</h3><div>This cross-sectional study (<em>n</em> = 3512) identified a robust positive association between CTI and the risk of OSA. Full adjustment revealed 14 % increased OSA odds per CTI unit (OR = 1.14, 95 %CI 1.05–1.24), with the highest quartile demonstrating 1.35–fold elevated risk versus the lowest (95 %CI 1.08–2.70). Threshold analysis revealed nonlinear dynamics: CTI &lt;8.755 showed 78 % OSA risk increase per unit (<em>p</em> &lt; 0.001), versus 19 % increase above this threshold (<em>p</em> = 0.024). Subgroup analyses confirmed consistent associations across demographics. CTI outperformed hs-CRP and TyG in OSA discrimination (AUC = 0.597, 95 %CI 0.578–0.615).</div></div><div><h3>Conclusion</h3><div>This study demonstrates that elevated levels of the CTI are correlated with risk for OSA, indicating its potential utility as a biomarker for OSA.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108412"},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The continuous daily work of living with chronic obstructive pulmonary disease: An ethnographic study.","authors":"Samantha Louise Harrison, Kirsti Jane Loughran, Sophie Suri, A Franklin, Caroline Fernandes-James, Joanne Symm, Andrew Fisher, Eileen Kaner, Denis Martin, Jamie McPhee, Tim Rapley","doi":"10.1016/j.rmed.2025.108405","DOIUrl":"https://doi.org/10.1016/j.rmed.2025.108405","url":null,"abstract":"<p><strong>Introduction: </strong>People with COPD struggle to self-manage and engage in health behaviour. Most behavioural interventions target motivation.</p><p><strong>Aim: </strong>To understand the lived experience of people with COPD using an ethnographic approach.</p><p><strong>Methods: </strong>Participants aged ≥50y diagnosed with COPD took part in home observations and a subset were interviewed. Analysis used first-generation grounded theory and findings were cross-referenced with another dataset (n = 15 interviews).</p><p><strong>Results: </strong>Nine observations (>18hs, 82-150mins) and five interviews (74-114mins) were conducted. Other data confirmed themes. People with COPD plan every element of their daily lives to monitor for potential threats such as breathlessness, falling and incontinence. This constant strategic thinking requires considerable mental effort and time. At home, people have carefully curated routines e.g. having ready meals to avoid washing up, but in unfamiliar spaces greater effort is required. To attend new appointments, they need to learn about the local geography e.g. distance from a parking bay, location of the toilets in hospital, resting places. Routines are delicately balanced and when disturbed e.g. spilling cereal on the floor before a hospital appointment, it means physical exertion, breathlessness, panic, impacting on the next 2-3 days due to fatigue. There is variability in peoples' capacity to adapt at pace, dependent on social capital, financial resources and social support.</p><p><strong>Conclusion: </strong>People with COPD feel compelled to engage in constant risk monitoring and self-surveillance. This continuous 'cost-benefit analysis' limits capacity to incorporate additional activities into their routine and has strong implications for service design.</p>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"108405"},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Egyptian cystic fibrosis children including genotypes and phenotypes: A single tertiary center experience","authors":"Eman Mahmoud Fouda ,&nbsp;Samya Z. Nasr ,&nbsp;Heba M. Hamza ,&nbsp;Sylvia Micheal Hana ,&nbsp;Abeer Ramadan ,&nbsp;Rahma Farghaly Ali ,&nbsp;Sally Raafat Ishak","doi":"10.1016/j.rmed.2025.108411","DOIUrl":"10.1016/j.rmed.2025.108411","url":null,"abstract":"<div><h3>Background</h3><div>Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, presenting with a wide spectrum of phenotypic characteristics. CF diagnosis and management in Egypt are challenging due to limited awareness, diagnostic resources, and access to essential therapies. Our study aims to provide a comprehensive summary of Egyptian children with CF (cwCF) managed at our tertiary CF center and to outline future directions for developing national management guidelines and quality improvement initiatives to enhance CF care in Egypt.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted on 31 children with CF. Data collected included demographic information, clinical presentations, genetic mutations, laboratory findings, and pulmonary function testing. Disease severity was evaluated using the Schwachman-Kulczycki score, Bhalla scoring, and spirometry. Nutritional status was assessed using anthropometric measurements.</div></div><div><h3>Results</h3><div>The median age of CF diagnosis was 1 year, and symptoms started at 3 months of age, indicating delayed diagnosis. High rates of consanguinity (54.84 %) and sibling affliction (41.94 %) were observed. Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) were isolated in 41.94 % and 29.03 % of patients, respectively. Genetic testing revealed that 71 % of mutations were Class II, and the Delta F508 mutation was detected in 35.5 % of cases. 59 % of patients were underweight and 65 % stunted. Pulmonary function tests showed restrictive and mixed lung disease patterns (50 %). Four novel CFTR mutations were identified.</div></div><div><h3>Conclusion</h3><div>This study highlights the early onset, delayed diagnosis, and severe clinical burden of CF in Egyptian children.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108411"},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health and transplantation in cystic fibrosis","authors":"Anna M. Georgiopoulos ,&nbsp;Beth A. Smith ,&nbsp;Elisabeth P. Dellon ,&nbsp;Denis Hadjiliadis ,&nbsp;Rebecca Colman ,&nbsp;Tara M.D. Mullen ,&nbsp;Alexandra L. Quittner ,&nbsp;Yelizaveta I. Sher","doi":"10.1016/j.rmed.2025.108407","DOIUrl":"10.1016/j.rmed.2025.108407","url":null,"abstract":"<div><h3>Background</h3><div>People with cystic fibrosis (PWCF) and their caregivers may face the prospect of lung or liver transplantation as cystic fibrosis (CF) progresses. Despite the links between psychological distress, poor adherence and survival outcomes, their mental health needs may not be consistently addressed.</div></div><div><h3>Methods</h3><div>We conducted a narrative review of mental health aspects of transplantation in PWCF, including health-related quality of life (HRQoL), pre-transplant psychosocial evaluation, neuropsychiatric complications, and psychosocial and psychopharmacologic interventions.</div></div><div><h3>Results</h3><div>Depression, anxiety and post-traumatic stress are common in this population, along with neuropsychiatric complications including cognitive impairment, delirium, side effects of immunosuppression, and drug-drug interactions. CF-specific guidelines recommend routine screening for depression, anxiety, and unmet palliative care needs for PWCF throughout the lifespan. Peri-transplantation, systematic monitoring can modify risk factors for and identify and treat delirium. Guidelines recommend screening, evaluation, and referral to care for depression, anxiety, and PTSD within 6 months post-transplant for PWCF and caregivers. Mental health intervention studies indicate there is potential to improve depression, anxiety, HRQoL, and medical outcomes.</div></div><div><h3>Conclusions</h3><div>As CF progresses, patients and caregivers require preparation for the psychosocial aspects of transplant evaluation, including the salience of social support, treatment adherence, and the importance of early interventions for mental health and substance use disorders. Specialists in mental health, palliative care, and pain management can be enlisted to improve symptoms and functioning in PWCF and caregivers at all stages of the transplant process. Psychological and psychopharmacologic interventions may require adaptation to target the specific needs of PWCF with advanced disease.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108407"},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood body size and risk of chronic obstructive pulmonary disease in adulthood: a prospective cohort study.","authors":"Frida R Hansen, Dorthe C Pedersen, Flemming Madsen, Helena Backman, Jens-Ulrik S Jensen, Allan Linneberg, Katja B Leth-Møller, Jennifer L Baker","doi":"10.1016/j.rmed.2025.108416","DOIUrl":"https://doi.org/10.1016/j.rmed.2025.108416","url":null,"abstract":"<p><strong>Introduction: </strong>Although previous studies have suggested links between childhood body size and lung function and asthma in adolescence and adulthood, the association with COPD is unclear. Therefore, we investigated whether trajectories of body mass index (BMI) in childhood were associated with COPD in adulthood.</p><p><strong>Methods: </strong>In this prospective cohort study, we included 276,747 children born from 1930-1982, with weight and height measurements available at ages 6-15 years from the Copenhagen School Health Records Register. We followed individuals from 1977 to 2022 in national health registers and identified those with a COPD diagnosis from age 40 years onwards. Hazard ratios (HR) and 95% confidence intervals (CI) for the associations between five childhood BMI trajectories and COPD were estimated separately for females and males using Cox proportional hazard regression analyses.</p><p><strong>Results: </strong>During follow-up, 18,227 females and 15,789 males had a COPD diagnosis. Compared to females with an average childhood BMI trajectory, a higher hazard of COPD was observed for females who had an above-average (HR=1.10; 95%CI: 1.06-1.15), overweight (HR=1.26; 95%CI: 1.20-1.33) or obesity BMI trajectory (HR=1.65; 95%CI: 1.50-1.83). Results were largely similar for males. Among females, a below average childhood BMI trajectory was associated with a lower hazard of COPD (HR=0.91; 95%CI: 0.87-0.95).</p><p><strong>Conclusion: </strong>We found that a BMI trajectory above average throughout childhood was positively associated with COPD in adulthood. Thus, our results suggest that having overweight or obesity during this early period of life is an indicator of risk for the later development of COPD.</p>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"108416"},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}