Associations of the prevalence of chronic respiratory diseases and mortality with blood furan levels: a population-based study.

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Respiratory medicine Pub Date : 2025-10-10 DOI:10.1016/j.rmed.2025.108422

Shuwen Zhang, Kunlu Shen, Bingqing Sun, Bowen Liu, Chunxiao Li, Mengqi Zhou, Xin Hou, Min Xiang, Jiangtao Lin

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引用次数: 0

Abstract

Background: Few studies have explored the role of furan exposure plays in chronic respiratory diseases and mortality.

Objective: To access the relationship of furan exposure to chronic respiratory diseases and mortality.

Methods: This study involves 5,261 adults over 20 years old from the National Health and Nutrition Examination Survey (NHANES) 2007-2012. Blood furan levels were employed to quantify furan exposure. Multinomial survey-weighted regressions were utilized to analyze the associations between furan exposure and the prevalence of asthma alone, COPD alone, and ACO. Multiple Cox regression was employed to evaluate the association between furan exposure and all-cause and respiratory mortality.

Results: After adjusting for covariates, log10-transformed blood furan levels (LBFL) were independently associated with an increased risk of the prevalence of asthma alone, COPD alone, and ACO (aOR = 2.086, 95% CI = 1.005 - 4.332, P = 0.049; aOR = 6.503, 95% CI = 3.471 - 12.185, P < 0.001; aOR = 10.739, 95% CI = 2.250 - 51.246, P = 0.003). For every one-unit increase in the LBFL, the odds of asthma were 1.086 higher, COPD were 5.503 higher, ACO were 9.739 higher. Longitudinally, LBFL were positively correlated with all-cause and respiratory mortality (HR = 1.997, 95% CI = 1.015 - 3.931, P = 0.045; HR = 4.979, 95% CI = 1.053 - 23.541, P = 0.043).

Conclusions: Exposure to furan revealed a positive association with greater odds of asthma, COPD, and ACO. An elevated blood furan also is associated with increased all-cause and respiratory mortality.

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慢性呼吸系统疾病患病率和死亡率与血液呋喃水平的关系：一项基于人群的研究

背景：很少有研究探讨呋喃暴露在慢性呼吸道疾病和死亡率中的作用。目的：探讨呋喃暴露与慢性呼吸系统疾病的关系。方法：本研究涉及2007-2012年国家健康与营养调查（NHANES）中5261名20岁以上的成年人。血液呋喃水平被用来量化呋喃暴露。使用多项调查加权回归分析呋喃暴露与单独哮喘、单独COPD和ACO患病率之间的关系。采用多重Cox回归来评估呋喃暴露与全因死亡率和呼吸道死亡率之间的关系。结果：经协变量调整后，log10转化血呋啶水平（LBFL）与单独哮喘、单独COPD和ACO患病率增加的独立相关（aOR = 2.086, 95% CI = 1.005 ~ 4.332, P = 0.049; aOR = 6.503, 95% CI = 3.471 ~ 12.185, P < 0.001; aOR = 10.739, 95% CI = 2.250 ~ 51.246, P = 0.003）。LBFL每增加1个单位，哮喘风险增加1.086，COPD风险增加5.503，ACO风险增加9.739。纵向上，LBFL与全因死亡率和呼吸系统死亡率呈正相关（HR = 1.997, 95% CI = 1.015 ~ 3.931, P = 0.045; HR = 4.979, 95% CI = 1.053 ~ 23.541, P = 0.043）。结论：呋喃暴露与哮喘、慢性阻塞性肺病和慢性阻塞性肺疾病的发病率呈正相关。血呋喃升高也与全因死亡率和呼吸系统死亡率增加有关。

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来源期刊

Respiratory medicine 医学-呼吸系统

CiteScore

7.50

自引率

0.00%

发文量

199

审稿时长

38 days

期刊介绍： Respiratory Medicine is an internationally-renowned journal devoted to the rapid publication of clinically-relevant respiratory medicine research. It combines cutting-edge original research with state-of-the-art reviews dealing with all aspects of respiratory diseases and therapeutic interventions. Topics include adult and paediatric medicine, epidemiology, immunology and cell biology, physiology, occupational disorders, and the role of allergens and pollutants. Respiratory Medicine is increasingly the journal of choice for publication of phased trial work, commenting on effectiveness, dosage and methods of action.