Respiratory medicine最新文献

{"title":"Age-related changes of inflammatory cytokines in nasal secretion of patients with chronic rhinosinusitis","authors":"Fang Chen ,&nbsp;Chaosheng Yu ,&nbsp;Tao Zhang ,&nbsp;Congxiang Shen ,&nbsp;Yonghe Li ,&nbsp;Hongzheng Zhang","doi":"10.1016/j.rmed.2025.108082","DOIUrl":"10.1016/j.rmed.2025.108082","url":null,"abstract":"<div><h3>Background</h3><div>Patient-specific factors are highly involved in chronic rhinosinusitis (CRS) 's course and treatment response. However, the effects of aging on the pathophysiology of CRS remain unclear. This study aimed to evaluate the age-related changes in nasal secretion inflammatory characteristics in patients with CRS.</div></div><div><h3>Methods</h3><div>The levels of 12 inflammatory cytokines in nasal mucus samples obtained from 31 patients diagnosed with CRS were measured via enzyme-linked immunosorbent assays. The associations between age and inflammatory cytokine levels were determined by Spearman correlation coefficient analysis. In addition, the relationships between inflammatory markers and demographic evaluation variables such as the Sino-Nasal Outcome Test-22 (SNOT-22) score and disease duration were examined to determine whether the levels of inflammatory cytokines influence the assessment of disease severity in CRS patients.</div></div><div><h3>Results</h3><div>Compared to younger patients with CRS, aged CRS patients exhibited a significant reduction in IL-6 levels (p &lt; 0.01), while levels of IL-10 (p &lt; 0.01), IL-13 (p &lt; 0.01), and Eotaxin (p &lt; 0.05) were markedly elevated. Notably, the Eotaxin level demonstrated a significant decline with age among CRS patients younger than 60 years old (r = −0.79, p &lt; 0.001). Furthermore, the increased mucus TNF-α level was significantly correlated with the prolongation of the disease course in aged CRS patients, with a clinically relevant difference of 7.78 months (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>We have revealed age-specific changes in the inflammatory characteristics of CRS patients, providing new and interesting findings for the development of personalized treatment methods tailored to this high-risk population.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"241 ","pages":"Article 108082"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Evaluation of the benefits of respirator breathing and vomiting training and dynamic core training on improving respiratory muscle strength\" [Respir. Med. 240 (2025) 108029].","authors":"Ran He, Lin Ren","doi":"10.1016/j.rmed.2025.108060","DOIUrl":"10.1016/j.rmed.2025.108060","url":null,"abstract":"","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"108060"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically Determined α-Klotho Levels and Causal Association with Aging-Related Lung Diseases.","authors":"Chen Jin, Yuwen Li","doi":"10.1016/j.rmed.2025.108081","DOIUrl":"https://doi.org/10.1016/j.rmed.2025.108081","url":null,"abstract":"<p><strong>Background: </strong>Abnormal α-Klotho (KL) levels play an essential role in the pathogenesis of aging-related lung diseases. However, the correlation between circulating KL levels and aging-related lung diseases has not been determined. This study aimed to determine whether circulating KL levels causally affect aging-related lung diseases using Mendelian randomization (MR).</p><p><strong>Methods: </strong>Five KL-associated Single-nucleotide polymorphisms (SNPs) were analyzed using two-sample MR to assess their effects on three aging-related lung diseases: idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and lung cancer.</p><p><strong>Results: </strong>Based on a main casual effects model with MR analyses by the inverse variance weighted (IVW) method including multiplicative random-effects model (IVW-mre) and fixed-effects inverse variance-weighted model (IVW-fe), genetically predicted circulating KL levels were negatively related with risk of IPF (Odds ratio (OR_IVW-mre), 0.999, 95% CI, 0.999-1.000, P_IVW-mre = 0.008; OR _IVW-fe, 0.999, 95% CI, 0.999-1.000, P_IVW-fe = 0.042). Inversely, the circulating levels of KL displayed no clear association with COPD and lung cancer. No pleiotropy was detected.</p><p><strong>Conclusions: </strong>Genetically predicted circulating KL was causally associated with a lower risk of IPF, suggesting a protective effect in preventing IPF risk. Therefore, KL may be a promising target for the prevention and therapeutic intervention in patients with IPF.</p>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"108081"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of small airway dysfunction assessed by impulse oscillometry with lung function decline and exacerbations in participants with chronic obstructive pulmonary disease: A prospective cohort study in China","authors":"Lifei Lu ,&nbsp;Fan Wu ,&nbsp;Gaoying Tang ,&nbsp;Qi Wan ,&nbsp;Zhishan Deng ,&nbsp;Jieqi Peng ,&nbsp;Cuiqiong Dai ,&nbsp;Kunning Zhou ,&nbsp;Xiaohui Wu ,&nbsp;Shuqing Yu ,&nbsp;Yongqing Huang ,&nbsp;Changli Yang ,&nbsp;Shengtang Chen ,&nbsp;Pixin Ran ,&nbsp;Yumin Zhou","doi":"10.1016/j.rmed.2025.108075","DOIUrl":"10.1016/j.rmed.2025.108075","url":null,"abstract":"<div><h3>Introduction</h3><div>Small airway dysfunction (SAD) assessed by impulse oscillometry (IOS) was common in patients with chronic obstructive pulmonary disease (COPD). However, little is known about the associations between IOS-defined small airway dysfunction (SAD) and the long-term prognosis of COPD. This study aimed to explore the associations between IOS-defined SAD, lung function decline and exacerbations in patients with COPD.</div></div><div><h3>Methods</h3><div>We analyzed baseline and 2-year follow-up data from the prospective cohort study in China. We defined SAD using IOS parameters Z-score greater than the 1.645 or less than −1.645. Subsequently, these patients were divided into three groups based on the different criteria defined SAD using IOS (normal group [none IOS parameters abnormalities], inconsistent SAD [any IOS parameters abnormalities, but not all], consistent SAD [all of IOS parameters abnormalities]). Negative binomial regression was conducted to analyze the associations between SAD and exacerbations, while a multivariable linear regression model was utilized to identify associations between SAD and lung function decline.</div></div><div><h3>Results</h3><div>833 patients with COPD were enrolled in our study. SAD (defined by X5, AX, and Fres z-score) was associated with a faster decline in lung function and higher risk of exacerbation. Meanwhile, for inconsistent diagnosis of SAD, we observed that patients with consistent SAD and inconsistent SAD experienced a faster decline in FEV₁ and higher risk of exacerbations than those with normal group.</div></div><div><h3>Conclusions</h3><div>IOS-defined SAD was associated with worse outcomes in patients with COPD, and further clinical trials are needed to clarify whether early intervention to reduce the severity of small airway lesions can delay the progress of COPD.</div></div><div><h3>Trial registration</h3><div>Chinese Clinical Trial Registry, ChiCTR1900024643. Registered on 19 July 2019.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"241 ","pages":"Article 108075"},"PeriodicalIF":3.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Indacaterol vs Tiotropium in COPD patients due to biomass exposure in improving quality of life and reducing symptoms","authors":"Robinson E. Robles-Hernández ,&nbsp;Francisco Montiel-Lopez ,&nbsp;Mónica Velázquez-Uncal ,&nbsp;Raúl H. Sansores ,&nbsp;Rafael J. Hernández-Zenteno ,&nbsp;Rogelio Pérez-Padilla ,&nbsp;Alejandra Ramírez-Venegas","doi":"10.1016/j.rmed.2025.108074","DOIUrl":"10.1016/j.rmed.2025.108074","url":null,"abstract":"<div><h3>Background</h3><div>Few treatment trials have been tested on COPD patients associated with biomass smoke exposure (COPD-B). Patients with COPD-B improve hyperinflation 24 hours after inhaling long-acting beta-agonist (LABA) and long-acting muscarinic antagonist (LAMA), and after six months of treatment, improve symptoms, quality of life, and exacerbations. However, the usefulness of LAMA or LABA for an extended period for improving quality of life and symptoms has not yet been demonstrated in the COPD-B phenotype. The primary aim of this trial was to compare tiotropium (TIO) with indacaterol (IND) in improving the quality of life (QOL) measured by the Saint George's Respiratory Questionnaire (SGRQ) in COPD-B after six months of treatment.</div></div><div><h3>Methods</h3><div>A randomized, open-label, parallel-group clinical trial designed at a third-level health institute in Mexico City. Seventy-three COPD-B women were randomly assigned to either 150 mcg of indacaterol or 18 mcg of tiotropium once daily for 24 weeks.</div></div><div><h3>Results</h3><div>197 patients underwent the screening visit, of which 73 were randomized. There was no significant change in the three domains nor the total score of the SGRQ in either treatment group. For secondary outcomes, the TIO group showed a substantial change in the IC of 160 mL (p=0.016) after six month-treatment. For both treatment groups, a significant reduction in BDI/TDI score of 3 points was shown (p&lt;0.001).</div></div><div><h3>Conclusions</h3><div>Neither TIO nor IND improved quality of life, nor dyspnea evaluated by the mMRC scale, but TIO did improve inspiratory capacity, and TIO and IND improved dyspnea evaluated by BDI/TDI.</div></div><div><h3>Clinical Trial Registration</h3><div>NCT05506865</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"241 ","pages":"Article 108074"},"PeriodicalIF":3.5,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a respiratory therapist-led, community-based asthma program in an under resourced rural border town In California","authors":"Torrie Staten ,&nbsp;Ping-Hui Liu ,&nbsp;Catalina Holt ,&nbsp;Abdullah Alismail","doi":"10.1016/j.rmed.2025.108071","DOIUrl":"10.1016/j.rmed.2025.108071","url":null,"abstract":"<div><h3>Introduction</h3><div>Asthma affects over 300 million people globally, with a higher prevalence in Imperial County, California, due to environmental and social factors. The Asthma Community Linkages Project (ACLP) seeks to reduce emergency visits and enhance asthma self-management through respiratory therapist-led(RT-Led) initiatives. The purpose of this study was to evaluate the effectiveness of using RT-led community-based program in Imperial Country, CA.</div></div><div><h3>Methods</h3><div>Conducted as a quality improvement study, the ACLP is a community-based initiative piloted in Imperial County's local hospitals and rural health clinics through the Asthma Management Program (AMP) and Asthma Wellness Program (AWP) from 2017 to 2020. Participants included 233 patients diagnosed with asthma, identified through ED visits. The program incorporated baseline clinical services, educational modules, and up to three home visits focused on asthma education and trigger mitigation. Data analysis employed paired t-tests and chi-squared tests to assess changes in Asthma Control Test (ACT) scores and ED visit frequency pre-and post-intervention.</div></div><div><h3>Results</h3><div>The study observed significant improvements in asthma control, with ACT scores rising significantly from 15.5 ± 3.03 to 21.33 ± 1.64 (p &lt; 0.001) within six months post-intervention. Notably, completing all three home visits was significantly associated with reduced ED visits at six and twelve months (p &lt; 0.01; p = 0.046). Among the participants, 58.4 % received at least one home visit, underscoring the intervention's reach and impact.</div></div><div><h3>Conclusion</h3><div>The ACLP, a respiratory therapist-led asthma program in Imperial County, California, improved asthma management and reduced emergency department visits. Using an evidence-based practice model and the Plan-Do-Check-Act framework, it addressed environmental and social health determinants through an interdisciplinary approach. The results demonstrated better asthma control in underserved areas, offering valuable insights for similar initiatives in resource-limited settings.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"241 ","pages":"Article 108071"},"PeriodicalIF":3.5,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulse corticosteroid therapy in interstitial lung disease-associated with anti-aminoacyl-tRNA synthetase antibodies: Comparable efficacy with potential for reduced adverse events","authors":"Shota Kaburaki,&nbsp;Toru Tanaka,&nbsp;Koichiro Kamio,&nbsp;Akihiko Miyanaga,&nbsp;Namiko Taniuchi,&nbsp;Yosuke Tanaka,&nbsp;Kazuo Kasahara,&nbsp;Masahiro Seike","doi":"10.1016/j.rmed.2025.108070","DOIUrl":"10.1016/j.rmed.2025.108070","url":null,"abstract":"<div><h3>Background and objective</h3><div>The optimal treatment modality for interstitial lung disease (ILD) associated with anti-aminoacyl-tRNA synthetase (ARS) antibodies remains controversial. This study aimed to compare the efficacy and safety of pulse corticosteroid therapy with that of conventional corticosteroid therapy in patients with anti-ARS ILD.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included 62 patients with anti-ARS ILD. Patients were divided into two groups: Those who received pulse corticosteroid therapy (500–1000 mg of methylprednisolone intravenously for three days) and those who received conventional corticosteroid therapy. Primary outcomes included initial treatment response at one year and disease recurrence. Secondary outcomes were alterations in pulmonary function tests, KL-6 levels, prednisolone dose, and adverse events.</div></div><div><h3>Results</h3><div>Both the pulse corticosteroid therapy group and the conventional therapy group had similar rates of initial treatment improvement (90.3 % vs. 77.4 %, p = 0.301), with no significant differences in recurrence-free survival. Improvements in pulmonary function tests were comparable between the two groups. At 12 months, the mean daily prednisolone dose was 3.9 mg in the pulse therapy group compared with 6.0 mg in the conventional therapy group. The pulse corticosteroid therapy group also experienced fewer adverse events (25.8 % vs. 61.3 %, p = 0.010).</div></div><div><h3>Conclusion</h3><div>Pulse corticosteroid therapy provides similar treatment efficacy, earlier reduction in corticosteroid dosage, and a lower incidence of adverse events compared to conventional therapy in patients with anti-ARS ILD. These findings highlight the potential benefit of a steroid-sparing strategy, suggesting that pulse corticosteroid therapy may be considered an effective and safer option in managing this condition.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"241 ","pages":"Article 108070"},"PeriodicalIF":3.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oscillometry and spirometry derived ratios to assess small airways dysfunction in severe asthma patients taking tezepelumab","authors":"Robert Greig,&nbsp;Rory Chan,&nbsp;Brian Lipworth","doi":"10.1016/j.rmed.2025.108072","DOIUrl":"10.1016/j.rmed.2025.108072","url":null,"abstract":"","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"241 ","pages":"Article 108072"},"PeriodicalIF":3.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in gut microbial community structure in obstructive sleep apnea /hypopnea syndrome (OSAHS): A systematic review and meta-analysis","authors":"Ali Tahmasebi ,&nbsp;Rasa Beheshti ,&nbsp;Mohammadsina Mahmoudi ,&nbsp;Mahan Jalilzadeh ,&nbsp;Hanieh Salehi-Pourmehr","doi":"10.1016/j.rmed.2025.108077","DOIUrl":"10.1016/j.rmed.2025.108077","url":null,"abstract":"<div><h3>Objectives</h3><div>This systematic review investigates gut bacterial diversity and composition in patients with Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) and examines how these changes may contribute to cardiovascular complications.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in PubMed, Web of Science, and Scopus up to March 2025. After removing duplicates, titles and abstracts were screened by two reviewers, and full texts were assessed for inclusion. Data extraction on study characteristics and outcomes was performed. Methodological quality was evaluated using the Joanna Briggs Institute checklist. α-diversity was assessed using richness and diversity indices, while β-diversity examined community structure differences. Meta-analysis was conducted using standardized mean differences (SMD) and confidence intervals (CIs), and heterogeneity was assessed with the Cochrane I² test.</div></div><div><h3>Results</h3><div>The review included 18 studies (16 adults, 2 pediatrics) examining the gut microbiome in OSAHS. Meta-analysis revealed significant reductions in α-diversity indices (Shannon, Chao1, observed species, ACE) in OSAHS patients, while Simpson's index showed no difference. β-diversity analyses showed distinct gut microbiome differences in OSA. Key differential bacteria included Bacteroides, Proteobacteria, Faecalibacterium, Ruminococcaceae, Megamonas, Oscillibacter, Dialister, Roseburia, and Lachnospira. Study quality was medium to high.</div></div><div><h3>Conclusion</h3><div>OSAHS is associated with significant gut microbiome alterations, including a reduction in beneficial bacteria and an increase in LPS-producing bacteria, leading to intestinal barrier dysfunction. These changes may contribute to systemic inflammation and elevate the risk of cardiovascular diseases.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"241 ","pages":"Article 108077"},"PeriodicalIF":3.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing methodological rigor in TCE for COPD rehabilitation","authors":"Jiahui Hong ,&nbsp;Shuding Yan ,&nbsp;Yue Lin","doi":"10.1016/j.rmed.2025.108073","DOIUrl":"10.1016/j.rmed.2025.108073","url":null,"abstract":"","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"241 ","pages":"Article 108073"},"PeriodicalIF":3.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}