Individual factors affecting oxygen saturation under acute hypoxia exposure in air personnel

IF 3.5 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Respiratory medicine Pub Date : 2025-05-23 DOI:10.1016/j.rmed.2025.108175

Idan Nakdimon , Daniela Algranati , Asaf Glass , Anna Levkovsky , Uri Eliyahu , Oded Ben-Ari , Barak Gordon

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引用次数: 0

Abstract

During flight, cabin pressure failure or oxygen system malfunction may lead to an oxygen-deprived environment, which could lead to a physiological state of hypoxia. Personal tolerance will determine cognitive performance level under these conditions. The aim of this study was to examine the influence of different parameters on hypoxia tolerance. As cognitive function was previously found to be associated with oxygen saturation levels (SatO₂), hypoxia tolerance was assessed using this method. A linear mixed models analysis revealed a significant correlation between decreased SatO₂ and BMI, hemoglobin levels, smoking, FEV1/FVC ratio, and age. In a further analysis, higher SatO₂ levels were significantly and independently associated in smokers (p = 0.012) and trainees with BMI above 27.7 kg/m² (p = 0.025 to 0.032). Moreover, non-smoking trainees with hemoglobin value above 15.9 g/dL (p = 0.016), and non-smoking trainees with FEV1/FVC ratio below 0.78 (p = 0.040 to 0.049) were correlated with significantly higher SatO₂. In this analysis, age, sex, and physical activity were not found to be correlated with SatO₂. Higher SatO₂ levels are correlated with higher hypoxia tolerance, hence the aforementioned parameters increase hypoxia tolerance. It is recommended to take these parameters into consideration during dedicated hypoxia trainings.

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影响空气人员急性缺氧暴露时血氧饱和度的个体因素

在飞行过程中，客舱压力故障或供氧系统故障可能导致缺氧环境，从而导致缺氧的生理状态。在这些条件下，个人容忍度将决定认知表现水平。本研究旨在探讨不同参数对低氧耐受性的影响。由于先前发现认知功能与氧饱和度（SatO2）相关，因此使用该方法评估了缺氧耐受性。线性混合模型分析显示，SatO2的降低与BMI、血红蛋白水平、吸烟、FEV1/FVC比值和年龄有显著相关性。在进一步的分析中，较高的SatO2水平与吸烟者（p = 0.012）和BMI高于27.7 kg/m2的学员（p = 0.025至0.032）有显著且独立的相关性。非吸烟受训人员血红蛋白值高于15.9 g/dL （p = 0.016）和FEV1/FVC比值低于0.78 （p = 0.040 ~ 0.049）与SatO2显著升高相关。在这项分析中，年龄、性别和身体活动与SatO2没有相关性。较高的SatO2水平与较高的缺氧耐受性相关，因此上述参数增加了缺氧耐受性。建议在专门的低氧训练中考虑这些参数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory medicine 医学-呼吸系统

CiteScore

7.50

自引率

0.00%

发文量

199

审稿时长

38 days

期刊介绍： Respiratory Medicine is an internationally-renowned journal devoted to the rapid publication of clinically-relevant respiratory medicine research. It combines cutting-edge original research with state-of-the-art reviews dealing with all aspects of respiratory diseases and therapeutic interventions. Topics include adult and paediatric medicine, epidemiology, immunology and cell biology, physiology, occupational disorders, and the role of allergens and pollutants. Respiratory Medicine is increasingly the journal of choice for publication of phased trial work, commenting on effectiveness, dosage and methods of action.