Effect of chronic kidney disease on survival in patients with chronic obstructive pulmonary disease

IF 3.5 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Respiratory medicine Pub Date : 2025-05-26 DOI:10.1016/j.rmed.2025.108181

Chen-Chuan Hsu , Pi-Hung Tung , Ting-Yu Lin , Shih-Wei Huang , Tsu-Chuan Li , Bing-Chen Wu , Chiung-Hsin Chang , Hao-Ming Wu , Chun-Yu Lo , Chun-Yu Lin , Horng-Chyuan Lin , Shu-Min Lin

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引用次数: 0

Abstract

Background

Chronic obstructive pulmonary disease (COPD) is a common respiratory disease associated with several comorbidities. Although chronic kidney disease (CKD) has been recognized as one such comorbidity, the effect of CKD on survival in patients with COPD remains uncertain. This study investigated the clinical impact of CKD in patients with COPD, accounting for clinically characteristics and 6-min walking test (6MWT) results.

Materials and methods

Patients with COPD who completed the 6MWT and a 3-year follow-up were retroactively enrolled in the study. Data on clinical information, 6MWT parameters, and outcomes were collected and analyzed.

Results

Among the 141 patients with COPD enrolled, 33 (23.4 %) had comorbid CKD. Patients with CKD were significantly older and more likely to experience heart failure, mortality, and FEV1 decline than patients without CKD. Multivariate analysis revealed that 6-min walking distance <350 m (odds ratio [OR]: 3.65, 95 % confidence interval [CI]: 1.05–12.06, p = 0.041) and CKD (OR: 4.66, 95 % CI: 1.30–16.76, p = 0.018) were independent risk factors for mortality.

Conclusions

Comorbid CKD was associated with an increased mortality rate and rapid FEV1 decline in patients with COPD. Patients with COPD and comorbid CKD may require intensive monitoring during treatment.

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慢性肾脏疾病对慢性阻塞性肺疾病患者生存的影响

背景：慢性阻塞性肺疾病（COPD）是一种常见的呼吸系统疾病，伴有多种合并症。虽然慢性肾脏疾病（CKD）已被认为是一种这样的合并症，但CKD对COPD患者生存的影响仍不确定。本研究探讨慢性阻塞性肺病患者CKD的临床影响，考虑临床特征和6分钟步行试验（6MWT）结果。材料和方法完成6MWT和3年随访的COPD患者追溯入组研究。收集并分析临床资料、6MWT参数和结果数据。结果141例COPD患者中，33例（23.4%）合并CKD。CKD患者明显比无CKD患者年龄更大，更容易出现心力衰竭、死亡率和FEV1下降。多因素分析显示，6分钟步行距离<；350 m（比值比[OR]: 3.65, 95%可信区间[CI]: 1.05 ~ 12.06, p = 0.041）和CKD（比值比：4.66,95% CI: 1.30 ~ 16.76, p = 0.018）是死亡的独立危险因素。结论共病CKD与COPD患者死亡率增加和FEV1快速下降相关。慢性阻塞性肺病合并慢性肾病患者在治疗期间可能需要加强监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory medicine 医学-呼吸系统

CiteScore

7.50

自引率

0.00%

发文量

199

审稿时长

38 days

期刊介绍： Respiratory Medicine is an internationally-renowned journal devoted to the rapid publication of clinically-relevant respiratory medicine research. It combines cutting-edge original research with state-of-the-art reviews dealing with all aspects of respiratory diseases and therapeutic interventions. Topics include adult and paediatric medicine, epidemiology, immunology and cell biology, physiology, occupational disorders, and the role of allergens and pollutants. Respiratory Medicine is increasingly the journal of choice for publication of phased trial work, commenting on effectiveness, dosage and methods of action.