Respiratory medicine最新文献

{"title":"Epidemiology, disease burden of pulmonary arterial hypertension in China: A systematic literature review","authors":"Caojin Zhang ,&nbsp;Helen Ding ,&nbsp;Jiahe Li ,&nbsp;Dena R. Ramey ,&nbsp;Bingbing Zhu ,&nbsp;Zirui Zhou ,&nbsp;Mei Yang ,&nbsp;Dominik Lautsch","doi":"10.1016/j.rmed.2025.108007","DOIUrl":"10.1016/j.rmed.2025.108007","url":null,"abstract":"<div><h3>Introduction</h3><div>Although pulmonary arterial hypertension (PAH) may impose a substantial burden in China, the epidemiology of PAH remains unclear. This systematic literature review (SLR) aims to synthesize the literature on PAH epidemiology and disease burden in China.</div></div><div><h3>Methods</h3><div>A systematic literature review was conducted using original publications since 2013. Comprehensive searches were performed in both English (EMBASE, MEDLINE) and Chinese (CNKI, Wanfang) databases. Articles were included when information on epidemiology, natural history, humanistic or economic burden of PAH was available.</div></div><div><h3>Results</h3><div>Among 4808 abstracts and 333 full-text articles identified, 156 met inclusion/exclusion criteria: natural history (155), epidemiology (17), health-related quality of life (HRQoL) (32), health resource utilization (HCRU) (8) and cost (3). Majority (85.9 %) relied on single-hospital data. No studies reported population-level incidence or prevalence. Congenital heart disease associated PAH (CHD-PAH) was the most common PAH-subtype. Of the 155 studies, 55.5 % focused on connective tissue disease-associated PAH (CTD-PAH). Excluding studies of special groups, the median proportion of female was 74.3 % (range: 55.0 %–95.0 %), the median age was 36.2 years (range: 32.3–55.6 years), and the median 5-year survival rate was 74.1% (range:15.0%–87.6%). For PAH-targeted therapy, monotherapy (primarily phosphodiesterase-5 inhibitors and endothelin receptor antagonists) was prescribed more often than combination therapies. 36-Item Short Form Survey (SF-36) was the most utilized HRQoL instrument. Among 32 studies detailing HRQoL, 14 demonstrated a significant improvement in HRQoL after intervention. One study reported that 70.0 % of PAH patients were hospitalized at least once a year, and 14.0 % were hospitalized 3–5 times a year. One study highlighted substantial economic burden, citing average annual out-of-pocket costs of $10,388 per patient in 2021.</div></div><div><h3>Conclusion</h3><div>In China, PAH is predominantly reported among young females, and the most common reported subtype is CHD-PAH. Population-level studies are needed to better understand the epidemiology, treatment patterns, and disease burden of PAH.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"240 ","pages":"Article 108007"},"PeriodicalIF":3.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with short- and medium-term mortality after hospitalization for COPD exacerbation","authors":"Arantza Cano ,&nbsp;Cristóbal Esteban ,&nbsp;Nere Larrea ,&nbsp;Milagros Iriberri ,&nbsp;Raquel Sánchez ,&nbsp;Alberto Jiménez-Puente ,&nbsp;Javier de-Miguel-Díez ,&nbsp;Miren Orive ,&nbsp;Jose María Quintana","doi":"10.1016/j.rmed.2025.108010","DOIUrl":"10.1016/j.rmed.2025.108010","url":null,"abstract":"<div><h3>Objective</h3><div>Hospitalization due to exacerbation is a critical event for patients with chronic obstructive pulmonary disease (COPD). This study aimed to identify predictive factors for mortality in patients post-hospitalization for COPD exacerbation and to determine differences in these predictors in the short and medium term.</div></div><div><h3>Methods</h3><div>A prospective observational study involving 1635 patients hospitalized for COPD exacerbation, followed for one year. Sociodemographic and clinical data, comorbidities, treatments, and quality of life questionnaires were assessed. Cox regression analysis identified mortality predictors at 2 months and &gt;2–12 months post-hospitalization.</div></div><div><h3>Results</h3><div>Mean age was 72.4 years with 76.6 % males. Overall, one-year mortality was 14.1 % (30.3 % of the deaths occurred within 2 months of discharge and 69.7 % occurred &gt;2–12 months post-discharge). Short-term mortality predictors included: age (HR [95 % CI] = 2.483 [1.501–4.107]), lower Barthel index (HR [95 % CI] = 1.274 [1.063–1.526]), pulmonary function (FEV1 &lt; 30 %: HR [95 % CI] = 5.153 [1.511–17.577]), and length of stay ≥8 days (HR [95 % CI] = 6.974 [2.504–19.419]). Medium-term predictors included: heart failure (HR [95 % CI] = 2.493 [1.318–4.717]), age (HR [95 % CI] = 1.690 [1.224–2.334]), lower Barthel index (HR [95 % CI] = 1.300 [1.149–1.472]), and pulmonary function (FEV1 &lt; 30 %: HR [95 % CI] = 3.000 [1.351–6.658] and FEV1 30–50 %: HR [95 % CI] = 2.010 [1.046–3.862]).</div></div><div><h3>Conclusions</h3><div>Mortality risk factors with exacerbated COPD after hospitalization vary over time. In the short term, length of hospital stay is prominent, while heart failure is more significant in the medium term. Age, dependency and pulmonary function were common predictors in both periods. Tailoring clinical interventions over time may improve health outcomes in this population.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"240 ","pages":"Article 108010"},"PeriodicalIF":3.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of probable COPD as proposed by the Lancet Commission at a smoking cessation clinic","authors":"Esra Ertan Yazar ,&nbsp;Elif Hazal Karadag ,&nbsp;Furkan Alp Eren ,&nbsp;Busra Demirci ,&nbsp;Burcu Arpinar Yigitbas ,&nbsp;Hacer Hicran Mutlu ,&nbsp;Handan Ankarali","doi":"10.1016/j.rmed.2025.108004","DOIUrl":"10.1016/j.rmed.2025.108004","url":null,"abstract":"<div><h3>Aims</h3><div>The recently published recommendations of the Lancet Commission, the presence of respiratory symptoms or exacerbation in risky people, and the COPD assessment test (CAT) score ≥10 points could be defined as possible COPD without using computed tomography and spirometry, particularly in low-income countries. We aimed to validate this recommendation by spirometry in patients applying to our smoking cessation clinic.</div></div><div><h3>Methods</h3><div>Subjects aged ≥40 years with a smoking history of ≥15 pack-years were included in the study. Individuals with known chronic lung diseases, except childhood asthma, were excluded. All participants completed a detailed case report form, including the CAT questionnaire, and underwent spirometry testing.</div></div><div><h3>Results</h3><div>A total of 224 participants, with a mean age of 53.2 ± 8.7 years of which 49.6 % were female, were enrolled in the study. According to the Lancet Commission's definition, 90 participants were identified as having probable COPD. Among these individuals, 21 (23.3 %) were also diagnosed with COPD based on the pre-bronchodilator FEV1/FVC ratio. In contrast, out of the 134 subjects, who did not meet the criteria for probable COPD, 12 (9 %) were diagnosed with COPD (P = 0.003).</div></div><div><h3>Conclusion</h3><div>This study is the first pilot study to validate the probable COPD definition recommended by the Lancet Commission using spirometry. Approximately 25 % of at-risk patients identified as having probable COPD were diagnosed with COPD based on the pre-bronchodilator FEV1/FVC ratio. Future studies are needed to assess the cost-effectiveness of the diagnostic approach outlined in the algorithm proposed by the Lancet Commission.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"239 ","pages":"Article 108004"},"PeriodicalIF":3.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaphragm function in patients with asthma and healthy controls: A cross-sectional study","authors":"Andrea Portacci ,&nbsp;Ilaria Iorillo ,&nbsp;Vitaliano Nicola Quaranta,&nbsp;Monica Amendolara,&nbsp;Flogerta Sana,&nbsp;Valeria Pezzuto,&nbsp;Santina Ferrulli,&nbsp;Silvano Dragonieri,&nbsp;Giovanna Elisiana Carpagnano","doi":"10.1016/j.rmed.2025.108008","DOIUrl":"10.1016/j.rmed.2025.108008","url":null,"abstract":"<div><h3>Background</h3><div>Asthma is a chronic respiratory disease characterized by airway inflammation and variable respiratory symptoms. While peripheral muscle deconditioning is known to affect lung function and exercise tolerance, the role of respiratory muscle dysfunction, particularly the diaphragm, remains underexplored.</div></div><div><h3>Objective</h3><div>We aim to evaluate potential differences in diaphragm function in patients with asthma.</div></div><div><h3>Methods</h3><div>We conducted a prospective, observational study comparing diaphragmatic function of 50 patients with asthma and 50 healthy controls. Two independent operators evaluated diaphragm contraction using tidal breathing thickening fraction (TF). Diaphragm dysfunction was defined as a TF &lt; 20 %. Additional assessments included flow-volume spirometry, impulse oscillometry (IOS), FeNO, blood eosinophil count, and the Sniff Inspiratory Nasal Pressure (SNIP) test.</div></div><div><h3>Results</h3><div>Patients with asthma demonstrated significantly reduced diaphragm TF compared to healthy controls (p &lt; 0.0001). Diaphragm dysfunction was significantly more prevalent in asthmatic patients (p &lt; 0.0001), affecting 62%–66 % of the right hemidiaphragm and 46%–54 % of the left. Reduced TF was associated with longer disease duration (p = 0.03) and higher exacerbation rates (p = 0.04). No significant correlations were observed between TF and anthropometric data, asthma treatments, lung function, or Th2 biomarkers. SNIP measurements did not correlate with diaphragm TF. The limited sample size and the cross-sectional design were the main limitations of the study.</div></div><div><h3>Conclusion</h3><div>Diaphragm dysfunction is prevalent in asthma and associated with disease severity, including exacerbation frequency and longer disease duration. Impaired diaphragm function may contribute to persistent symptoms and exercise intolerance, representing a novel treatable trait in asthma management.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"239 ","pages":"Article 108008"},"PeriodicalIF":3.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal respiratory trajectories in motor neuron disease phenotypes: Multiparametric characterization and clinical management","authors":"Pilar M. Ferraro ,&nbsp;Elena Mollar ,&nbsp;Laura Melissari ,&nbsp;Martina Buscema ,&nbsp;Emiliano Bagnoli ,&nbsp;Corrado Cabona ,&nbsp;Chiara Gemelli ,&nbsp;Manuela Vignolo ,&nbsp;Cinzia Maranzana ,&nbsp;Maura Marogna ,&nbsp;Lorenzo Ferrera ,&nbsp;Alessandro Beronio ,&nbsp;Claudio De Michelis ,&nbsp;Valeria Bergamaschi ,&nbsp;Margherita Monti Bragadin ,&nbsp;Giampaolo Brichetto ,&nbsp;Fulvio Braido ,&nbsp;Fabrizio Rao","doi":"10.1016/j.rmed.2025.108003","DOIUrl":"10.1016/j.rmed.2025.108003","url":null,"abstract":"<div><h3>Background</h3><div>Motor neuron diseases (MNDs) encompass amyotrophic lateral sclerosis (ALS), pure/predominant upper (pUMN) and lower motor neuron (pLMN) phenotypes. However respiratory studies have mainly focused on bulbar (B-ALS) and spinal (S-ALS) onset ALS, while little is known in other MNDs. In this study we therefore aimed at characterizing baseline and longitudinal patterns of respiratory involvement and their clinical management in MND patients stratified by their clinical phenotype.</div></div><div><h3>Methods</h3><div>Serial pulmonary function tests (PFTs) (spirometry, arterial blood gas analysis, overnight pulse oximetry and peak cough expiratory flow) records of the MND patients hospitalized between 2020 and 2024 were reviewed. Using longitudinal examinations, deltas of variation in respiratory measures were generated and frequency and timings of non-invasive ventilation (NIV) adaptation were evaluated. Data were compared between phenotypes using the Kruskal–Wallis test with Bonferroni adjustment.</div></div><div><h3>Results</h3><div>42 S-ALS, 105 B-ALS, 42 pLMN and 31 pUMN patients were included. Both at baseline and longitudinally, B-ALS showed the worst respiratory parameters, followed by pLMN, S-ALS and pUMN. NIV adaptation was equally frequent between groups, but earlier in B-ALS compared to pUMN (p = 0.01). At baseline, B-ALS showed worse spirometry and PCEF only, but compared to all the other phenotypes (p from &lt;0.0001 to 0.03). Longitudinally, they conversely exhibited more severe decline in all PFTs, but only relative to pUMN (p from 0.0009 to 0.04), with deltas of variation comparable to the ones observed in S-ALS and pLMN. Among NIV users, more severe PCEF and spirometry impairment further emerged in S-ALS compared to pUMN (p from 0.01 to 0.04).</div></div><div><h3>Conclusions</h3><div>We evidenced convergent trajectories of respiratory decline across B-ALS, S-ALS and pLMN, highlighting the utility of multimodal assessments for tracking progressing respiratory disturbances. These findings have potential to accelerate earlier and more tailored respiratory management across diverse MND phenotypes.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"239 ","pages":"Article 108003"},"PeriodicalIF":3.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising outcomes for adults with cystic fibrosis taking CFTR modulators by individualising care: Personalised data linkage to understand treatment optimisation (PLUTO), a novel clinical framework","authors":"Robert D. Sandler ,&nbsp;Alan Anderson ,&nbsp;Tracy Barnett ,&nbsp;Stephen J. Bourke ,&nbsp;Sarah Cameron ,&nbsp;Stephen J. Chapman ,&nbsp;Jocelyn Choyce ,&nbsp;Thom Daniels ,&nbsp;Tracey Daniels ,&nbsp;Sophie Dawson ,&nbsp;Simon Doe ,&nbsp;Michael Dooney ,&nbsp;Carlos Echevarria ,&nbsp;Penny Galey ,&nbsp;Giles Fitch ,&nbsp;Lana Y.H. Lai ,&nbsp;Julia A. Nightingale ,&nbsp;Michelle Thomas ,&nbsp;Rachael Thompson ,&nbsp;Joanna Whitehouse ,&nbsp;Martin J. Wildman","doi":"10.1016/j.rmed.2025.107995","DOIUrl":"10.1016/j.rmed.2025.107995","url":null,"abstract":"","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"239 ","pages":"Article 107995"},"PeriodicalIF":3.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of traditional Chinese exercise on pulmonary function in middle-aged and older patients with stable chronic obstructive pulmonary disease: A randomized controlled trial","authors":"Ziying Chen ,&nbsp;Hongyu Yue ,&nbsp;Yuanjia Gu ,&nbsp;Chaoqun Xie ,&nbsp;Jianwen Ma ,&nbsp;Fangfang Xie ,&nbsp;Guangdong Wang ,&nbsp;Fei Yao","doi":"10.1016/j.rmed.2025.107997","DOIUrl":"10.1016/j.rmed.2025.107997","url":null,"abstract":"<div><h3>Background</h3><div>Traditional Chinese exercise (TCE) has been shown effective for chronic obstructive pulmonary disease (COPD). However, there are no studies investigating the effect of traditional Chinese exercise (TCE) programme on COPD. The aim of this study was to evaluate the effectiveness of specific TCE programme on the pulmonary function in patients with COPD.</div></div><div><h3>Methods</h3><div>76 patients with COPD was randomly assigned to receive either TCE group or control group in a 1:1 ratio. The primary outcome was changes in forced vital capacity (FVC) from baseline to 12 weeks. Secondary outcomes included forced expiratory volume in the first second (FEV1), tidal volume (VT), inspiratory capacity (IC), expiratory reserve volume (ERV), FEV1/FVC, peak expiratory flow (PEF), the 6-min walking test (6MWT), the COPD Assessment Test (CAT), the Short Form 36-item Health Survey (SF-36), modified medical research council scale (mMRC).</div></div><div><h3>Results</h3><div>After 12 weeks, the TCE group demonstrated a significantly greater improvement of FVC (−12.67; 95 % CI, −18.21 to −7.15; <em>P</em> &lt; 0.001) and FEV1 (−9.70; 95 % CI, −13.73 to −5.68; <em>P</em> &lt; 0.001). But there was no statistically significant difference between groups in FEV1/FVC, PEF, VT, IC or ERV. Besides, patients in the TCE group also reported a statistically significant within-group difference at week 12 in CAT, mMRC and 6MWT. As for eight dimensions of SF-36, patients in TCE group had higher scores in SF-36 (<em>P</em> &lt; 0.05 for 8 dimensions).</div></div><div><h3>Conclusion</h3><div>Our results demonstrate that the traditional Chinese exercise can serve as an effective therapeutic tool for middle-aged and older patients with COPD.</div></div><div><h3>Trial registration number</h3><div>Chinese Clinical Trial Registry, ChiCTR2300069283, <span><span>https://www.chictr.org.cn/showproj.html?proj=192116</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"239 ","pages":"Article 107997"},"PeriodicalIF":3.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143430214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographic variability of interstitial lung disease diagnoses and impact of air pollution on disease outcomes","authors":"Annalise Bagust ,&nbsp;Cheng Zhao ,&nbsp;Lauren Troy ,&nbsp;Joe Van Buskirk ,&nbsp;Astrid Gardiner ,&nbsp;Megan Harrison ,&nbsp;Nathan Mortimer ,&nbsp;Luke D. Knibbs ,&nbsp;Tamera J. Corte","doi":"10.1016/j.rmed.2025.107996","DOIUrl":"10.1016/j.rmed.2025.107996","url":null,"abstract":"<div><h3>Background and objective</h3><div>Anecdotal reports suggest interstitial lung disease (ILD) phenotypes vary regionally. We aimed to assess geographic variability of ILD diagnoses and impact of air quality on disease outcomes across the state of New South Wales, Australia.</div></div><div><h3>Methods</h3><div>Consecutive patients referred to an ILD multidisciplinary meeting, receiving referrals from across NSW (Feb 2014–Feb 2017), were included. Comparative frequencies of ILD diagnoses between regions were compared using Fisher's exact tests. Satellite-based land use regression models were used to estimate mean annual air pollution exposure for patients' home address at diagnosis. Associations between air pollution exposure and mortality and disease progression were assessed using multivariable Cox proportional hazard models.</div></div><div><h3>Results</h3><div>437 ILD patients [mean age 67 ± 13 years; 41 % female, 48 % ever-smokers] were included. Air pollution at the year of diagnosis was 6.6 ± 2.0 μg/m³ for PM2.5, and 8.1 ± 4.2 ppb for NO₂. Exposure to NO₂ was significantly higher in major cities than in regional areas (p &lt; 0.001), while exposure to PM2.5 did not differ significantly (p = 0.373). In regional and remote areas, relative frequency of hypersensitivity pneumonitis (HP) was 1.75 times higher (p = 0.078) than in major cities. Among 329 ILD patients with ≥6 months follow-up data, disease outcomes were associated with specific ILD diagnosis and baseline FVC, but not associated with air pollution exposure.</div></div><div><h3>Conclusion</h3><div>We found a trend towards higher relative frequency of HP and lower relative frequency of non-IPF IIP in regional and remote areas compared to major cities. There was no association between mean air pollution exposure at diagnosis and disease outcomes.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"239 ","pages":"Article 107996"},"PeriodicalIF":3.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac-lung ultrasound and ventilator-weaning: Navigating the nuances","authors":"Rohan Magoon","doi":"10.1016/j.rmed.2025.107992","DOIUrl":"10.1016/j.rmed.2025.107992","url":null,"abstract":"","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"239 ","pages":"Article 107992"},"PeriodicalIF":3.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MHR as a promising predictor for coronary artery disease in COPD patients: Insights from a retrospective nomogram study","authors":"Feng Sun ,&nbsp;Mei Ye ,&nbsp;Ayididar Jumahan ,&nbsp;Aidibai Aainiwaier ,&nbsp;Yu Xia","doi":"10.1016/j.rmed.2025.107993","DOIUrl":"10.1016/j.rmed.2025.107993","url":null,"abstract":"<div><h3>Background and objective</h3><div>Chronic obstructive pulmonary disease (COPD) frequently co-occurs with coronary artery disease (CAD), adversely affecting patients morbidity and mortality. Identifying new risk factors for CAD in COPD patients is essential for improving clinical management and patients outcomes.</div></div><div><h3>Methods</h3><div>This retrospective case-control study analyzed 406 COPD patients who underwent coronary artery computed tomography angiography (CCTA). Patients were categorized into co-CAD and non-CAD groups based on CCTA findings. Demographic and laboratory data were assessed to determine independent risk factors for CAD in COPD patients using univariate and multivariate logistic regression analyses.</div></div><div><h3>Results</h3><div>The co-CAD group was significantly older, had a higher prevalence of males, and included a higher proportion of individuals with hypertension, diabetes, cardiovascular diseases, as well as cerebrovascular diseases, exhibiting lower FEV1 values (P &lt; 0.05). This group also exhibited higher levels of HbA1c, IL-6, monocyte count, and MHR (P &lt; 0.05). Multivariate logistic regression identified age, hypertension, and MHR as independent predictors of CAD. A nomogram incorporating these predictors demonstrated robust predictive accuracy with an area under the ROC curve of 0.758 (95 % CI: 0.704–0.814), effectively stratifying patients into high and low risk for CAD.</div></div><div><h3>Conclusion</h3><div>The identification of MHR as an independent predictor of CAD in COPD patients opens new avenues for understanding cardiovascular comorbidities. The nomogram's integration of MHR with age and hypertension provides an effective tool for early CAD detection and management, promising to enhance clinical outcomes and decrease mortality rates in COPD patients. These insights may inform future preventative strategies against CAD in COPD.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"239 ","pages":"Article 107993"},"PeriodicalIF":3.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}