Respiratory medicine最新文献

{"title":"Assessment of breathing patterns and voice of patients with COPD and dysphonia","authors":"Karolina Węglarz ,&nbsp;Elżbieta Szczygieł ,&nbsp;Agata Masłoń ,&nbsp;Jędrzej Blaut","doi":"10.1016/j.rmed.2025.108012","DOIUrl":"10.1016/j.rmed.2025.108012","url":null,"abstract":"<div><h3>Introduction</h3><div>There is a noticeable lack of studies relating to voice, breathing and how they relate to each other in patients with voice or respiratory diseases. Therefore, the aim of our study was to assess and compare the breathing pattern and voice variables in people with voice and respiratory disorders.</div></div><div><h3>Material and methods</h3><div>The research was conducted on a group of 61 persons, including 16 patients with chronic obstructive pulmonary disease (COPD), 15 patients with dysphonia and 30 healthy persons. Breathing pattern and voice variables were assessed in relaxed sitting position. The breathing parameters was evaluated separately for upper and lower chest using the respiratory inductive plethysmography. The recording of acoustic speech signal was performed using a dynamic stage microphone with a preamplifier and a digital signal recorder. The acoustic signal was further analysed by evaluating four parameters: Jitter, Shimmer, HNR and MFCC.</div></div><div><h3>Results</h3><div>In the sitting position, people with dysphonia and COPD had longer and deeper exhalations and deeper breaths than healthy subjects, regardless of the assessed track, however in the subjects with COPD higher for the abdominal track and for dysphonia subjects in thoracic track were observed. Subjects suffering from dysphonia were characterized by lower voice power and pitch and more distortions in the speech signal compared to healthy subjects, whereas both dysphonia and COPD patients had statistically significantly lower voice frequency compared to the control group.</div></div><div><h3>Conclusion</h3><div>Subjects with COPD made greater use of the diaphragmatic track in sitting position, whereas subjects with dysphonia used the thoracic track to a greater extent. Stronger correlations between voice and respiratory parameters for the abdominal track exist in people with voice or respiratory dysfunctions than in healthy subjects.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"240 ","pages":"Article 108012"},"PeriodicalIF":3.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of lifestyle components with prevalence of chronic obstructive pulmonary disease (COPD): Findings of a cohort study","authors":"Fatemeh Davoudi Dastenaei ,&nbsp;Saba Belyani ,&nbsp;Ali Jafarzadeh Esfahani ,&nbsp;Hossein Bahari ,&nbsp;Fatemeh Sadat Hashemi Javaheri ,&nbsp;Maryam Khosravi ,&nbsp;Mahnaz Amini ,&nbsp;Reza Rezvani","doi":"10.1016/j.rmed.2025.108013","DOIUrl":"10.1016/j.rmed.2025.108013","url":null,"abstract":"<div><h3>Background</h3><div>Chronic Obstructive Pulmonary Disease (COPD) is a complex condition influenced by various lifestyle factors. Dietary patterns, physical activity, and sleep quality play a crucial role in the prevalence and management of COPD.</div></div><div><h3>Objectives</h3><div>We aimed to evaluate the relationship between dietary patterns, physical activity, and sleep quality with the prevalence of COPD in the PERSIAN Organizational Cohort study at Mashhad University of Medical Sciences (POCM).</div></div><div><h3>Methods</h3><div>This cohort study utilized data from 12,000 participants in POCM. Dietary intake was assessed using a food frequency questionnaire, physical activity was measured using the International Physical Activity Questionnaire, and sleep quality was evaluated using the Pittsburgh Sleep Quality Index. Spirometry was performed to diagnose and categorize COPD severity.</div></div><div><h3>Results</h3><div>Out of the eligible 4269 participants, 3768 (91 %) were healthy and 373 (9 %) had COPD. Compared to the highest quartile, the second quartiles and third quartiles of the healthy dietary pattern were inversely associated with COPD prevalence, even after adjusting for confounders for the second and third quarters respectively. The second quartile of the fast-food dietary pattern was positively associated with COPD. Older age and poorer sleep quality were also significantly associated with higher COPD prevalence. Physical activity levels did not differ between healthy and COPD individuals.</div></div><div><h3>Conclusions</h3><div>Findings of this study indicate that healthy diet with more fruits, vegetables, and whole grains was related to reduced incidence of COPD, while the incidence of COPD was related to poor sleep quality. These findings highlight the possible interplay of lifestyle factors and respiratory health.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"240 ","pages":"Article 108013"},"PeriodicalIF":3.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracorporeal CO2 removal in severe respiratory acidotic intubated patients: A seven year experience observational study","authors":"Pilar Cobeta ,&nbsp;Antonio Gomis ,&nbsp;Sara Claver ,&nbsp;Marta Encuentra ,&nbsp;Sofía Rubin ,&nbsp;Elisa Salvador ,&nbsp;Paula Segura ,&nbsp;María T. Tenorio ,&nbsp;David Pestaña","doi":"10.1016/j.rmed.2025.108011","DOIUrl":"10.1016/j.rmed.2025.108011","url":null,"abstract":"<div><div>Severe hypercapnia increases the risk of non-protective ventilation and is associated with high mortality in critically ill patients. <em>In this study we</em> assess the use of low-flow extracorporeal CO2 removal (ECCO₂R) integrated into a renal platform and the factors related to patient outcome in a tertiary university hospital. Data from 73 patients with severe respiratory acidosis (pCO₂ &gt; 60 mmHg and Ph &lt; 7.25 for more than 3 h) at risk for ventilator-induced lung injury (VILI), were analysed. The median duration of the therapy was 96 h (IQR 58 to 163). We observed that early use of ECCO₂R (within 6h from meeting treatment criteria) was associated with a significant reduction in mortality (54.5 vs 77.5 %, <em>p</em> = 0.038) and a non-significant reduction in the duration of ECCO₂R therapy, mechanical ventilation days, ICU length of stay and need for tracheostomy. <em>Adverse events were found in 7 % of the patients, with no cases of major bleeding. A significant shorter mean life was observed for larger membranes (1.8 m²) in respec</em>t to 0.35 and 0.8 m². We conclude that ECCO₂R integrated into renal platforms is a feasible and safe technique in severe respiratory acidosis when there is risk for VILI.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"240 ","pages":"Article 108011"},"PeriodicalIF":3.5,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, disease burden of pulmonary arterial hypertension in China: A systematic literature review","authors":"Caojin Zhang ,&nbsp;Helen Ding ,&nbsp;Jiahe Li ,&nbsp;Dena R. Ramey ,&nbsp;Bingbing Zhu ,&nbsp;Zirui Zhou ,&nbsp;Mei Yang ,&nbsp;Dominik Lautsch","doi":"10.1016/j.rmed.2025.108007","DOIUrl":"10.1016/j.rmed.2025.108007","url":null,"abstract":"<div><h3>Introduction</h3><div>Although pulmonary arterial hypertension (PAH) may impose a substantial burden in China, the epidemiology of PAH remains unclear. This systematic literature review (SLR) aims to synthesize the literature on PAH epidemiology and disease burden in China.</div></div><div><h3>Methods</h3><div>A systematic literature review was conducted using original publications since 2013. Comprehensive searches were performed in both English (EMBASE, MEDLINE) and Chinese (CNKI, Wanfang) databases. Articles were included when information on epidemiology, natural history, humanistic or economic burden of PAH was available.</div></div><div><h3>Results</h3><div>Among 4808 abstracts and 333 full-text articles identified, 156 met inclusion/exclusion criteria: natural history (155), epidemiology (17), health-related quality of life (HRQoL) (32), health resource utilization (HCRU) (8) and cost (3). Majority (85.9 %) relied on single-hospital data. No studies reported population-level incidence or prevalence. Congenital heart disease associated PAH (CHD-PAH) was the most common PAH-subtype. Of the 155 studies, 55.5 % focused on connective tissue disease-associated PAH (CTD-PAH). Excluding studies of special groups, the median proportion of female was 74.3 % (range: 55.0 %–95.0 %), the median age was 36.2 years (range: 32.3–55.6 years), and the median 5-year survival rate was 74.1% (range:15.0%–87.6%). For PAH-targeted therapy, monotherapy (primarily phosphodiesterase-5 inhibitors and endothelin receptor antagonists) was prescribed more often than combination therapies. 36-Item Short Form Survey (SF-36) was the most utilized HRQoL instrument. Among 32 studies detailing HRQoL, 14 demonstrated a significant improvement in HRQoL after intervention. One study reported that 70.0 % of PAH patients were hospitalized at least once a year, and 14.0 % were hospitalized 3–5 times a year. One study highlighted substantial economic burden, citing average annual out-of-pocket costs of $10,388 per patient in 2021.</div></div><div><h3>Conclusion</h3><div>In China, PAH is predominantly reported among young females, and the most common reported subtype is CHD-PAH. Population-level studies are needed to better understand the epidemiology, treatment patterns, and disease burden of PAH.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"240 ","pages":"Article 108007"},"PeriodicalIF":3.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with short- and medium-term mortality after hospitalization for COPD exacerbation","authors":"Arantza Cano ,&nbsp;Cristóbal Esteban ,&nbsp;Nere Larrea ,&nbsp;Milagros Iriberri ,&nbsp;Raquel Sánchez ,&nbsp;Alberto Jiménez-Puente ,&nbsp;Javier de-Miguel-Díez ,&nbsp;Miren Orive ,&nbsp;Jose María Quintana","doi":"10.1016/j.rmed.2025.108010","DOIUrl":"10.1016/j.rmed.2025.108010","url":null,"abstract":"<div><h3>Objective</h3><div>Hospitalization due to exacerbation is a critical event for patients with chronic obstructive pulmonary disease (COPD). This study aimed to identify predictive factors for mortality in patients post-hospitalization for COPD exacerbation and to determine differences in these predictors in the short and medium term.</div></div><div><h3>Methods</h3><div>A prospective observational study involving 1635 patients hospitalized for COPD exacerbation, followed for one year. Sociodemographic and clinical data, comorbidities, treatments, and quality of life questionnaires were assessed. Cox regression analysis identified mortality predictors at 2 months and &gt;2–12 months post-hospitalization.</div></div><div><h3>Results</h3><div>Mean age was 72.4 years with 76.6 % males. Overall, one-year mortality was 14.1 % (30.3 % of the deaths occurred within 2 months of discharge and 69.7 % occurred &gt;2–12 months post-discharge). Short-term mortality predictors included: age (HR [95 % CI] = 2.483 [1.501–4.107]), lower Barthel index (HR [95 % CI] = 1.274 [1.063–1.526]), pulmonary function (FEV1 &lt; 30 %: HR [95 % CI] = 5.153 [1.511–17.577]), and length of stay ≥8 days (HR [95 % CI] = 6.974 [2.504–19.419]). Medium-term predictors included: heart failure (HR [95 % CI] = 2.493 [1.318–4.717]), age (HR [95 % CI] = 1.690 [1.224–2.334]), lower Barthel index (HR [95 % CI] = 1.300 [1.149–1.472]), and pulmonary function (FEV1 &lt; 30 %: HR [95 % CI] = 3.000 [1.351–6.658] and FEV1 30–50 %: HR [95 % CI] = 2.010 [1.046–3.862]).</div></div><div><h3>Conclusions</h3><div>Mortality risk factors with exacerbated COPD after hospitalization vary over time. In the short term, length of hospital stay is prominent, while heart failure is more significant in the medium term. Age, dependency and pulmonary function were common predictors in both periods. Tailoring clinical interventions over time may improve health outcomes in this population.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"240 ","pages":"Article 108010"},"PeriodicalIF":3.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of probable COPD as proposed by the Lancet Commission at a smoking cessation clinic","authors":"Esra Ertan Yazar ,&nbsp;Elif Hazal Karadag ,&nbsp;Furkan Alp Eren ,&nbsp;Busra Demirci ,&nbsp;Burcu Arpinar Yigitbas ,&nbsp;Hacer Hicran Mutlu ,&nbsp;Handan Ankarali","doi":"10.1016/j.rmed.2025.108004","DOIUrl":"10.1016/j.rmed.2025.108004","url":null,"abstract":"<div><h3>Aims</h3><div>The recently published recommendations of the Lancet Commission, the presence of respiratory symptoms or exacerbation in risky people, and the COPD assessment test (CAT) score ≥10 points could be defined as possible COPD without using computed tomography and spirometry, particularly in low-income countries. We aimed to validate this recommendation by spirometry in patients applying to our smoking cessation clinic.</div></div><div><h3>Methods</h3><div>Subjects aged ≥40 years with a smoking history of ≥15 pack-years were included in the study. Individuals with known chronic lung diseases, except childhood asthma, were excluded. All participants completed a detailed case report form, including the CAT questionnaire, and underwent spirometry testing.</div></div><div><h3>Results</h3><div>A total of 224 participants, with a mean age of 53.2 ± 8.7 years of which 49.6 % were female, were enrolled in the study. According to the Lancet Commission's definition, 90 participants were identified as having probable COPD. Among these individuals, 21 (23.3 %) were also diagnosed with COPD based on the pre-bronchodilator FEV1/FVC ratio. In contrast, out of the 134 subjects, who did not meet the criteria for probable COPD, 12 (9 %) were diagnosed with COPD (P = 0.003).</div></div><div><h3>Conclusion</h3><div>This study is the first pilot study to validate the probable COPD definition recommended by the Lancet Commission using spirometry. Approximately 25 % of at-risk patients identified as having probable COPD were diagnosed with COPD based on the pre-bronchodilator FEV1/FVC ratio. Future studies are needed to assess the cost-effectiveness of the diagnostic approach outlined in the algorithm proposed by the Lancet Commission.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"239 ","pages":"Article 108004"},"PeriodicalIF":3.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaphragm function in patients with asthma and healthy controls: A cross-sectional study","authors":"Andrea Portacci ,&nbsp;Ilaria Iorillo ,&nbsp;Vitaliano Nicola Quaranta,&nbsp;Monica Amendolara,&nbsp;Flogerta Sana,&nbsp;Valeria Pezzuto,&nbsp;Santina Ferrulli,&nbsp;Silvano Dragonieri,&nbsp;Giovanna Elisiana Carpagnano","doi":"10.1016/j.rmed.2025.108008","DOIUrl":"10.1016/j.rmed.2025.108008","url":null,"abstract":"<div><h3>Background</h3><div>Asthma is a chronic respiratory disease characterized by airway inflammation and variable respiratory symptoms. While peripheral muscle deconditioning is known to affect lung function and exercise tolerance, the role of respiratory muscle dysfunction, particularly the diaphragm, remains underexplored.</div></div><div><h3>Objective</h3><div>We aim to evaluate potential differences in diaphragm function in patients with asthma.</div></div><div><h3>Methods</h3><div>We conducted a prospective, observational study comparing diaphragmatic function of 50 patients with asthma and 50 healthy controls. Two independent operators evaluated diaphragm contraction using tidal breathing thickening fraction (TF). Diaphragm dysfunction was defined as a TF &lt; 20 %. Additional assessments included flow-volume spirometry, impulse oscillometry (IOS), FeNO, blood eosinophil count, and the Sniff Inspiratory Nasal Pressure (SNIP) test.</div></div><div><h3>Results</h3><div>Patients with asthma demonstrated significantly reduced diaphragm TF compared to healthy controls (p &lt; 0.0001). Diaphragm dysfunction was significantly more prevalent in asthmatic patients (p &lt; 0.0001), affecting 62%–66 % of the right hemidiaphragm and 46%–54 % of the left. Reduced TF was associated with longer disease duration (p = 0.03) and higher exacerbation rates (p = 0.04). No significant correlations were observed between TF and anthropometric data, asthma treatments, lung function, or Th2 biomarkers. SNIP measurements did not correlate with diaphragm TF. The limited sample size and the cross-sectional design were the main limitations of the study.</div></div><div><h3>Conclusion</h3><div>Diaphragm dysfunction is prevalent in asthma and associated with disease severity, including exacerbation frequency and longer disease duration. Impaired diaphragm function may contribute to persistent symptoms and exercise intolerance, representing a novel treatable trait in asthma management.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"239 ","pages":"Article 108008"},"PeriodicalIF":3.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal respiratory trajectories in motor neuron disease phenotypes: Multiparametric characterization and clinical management","authors":"Pilar M. Ferraro ,&nbsp;Elena Mollar ,&nbsp;Laura Melissari ,&nbsp;Martina Buscema ,&nbsp;Emiliano Bagnoli ,&nbsp;Corrado Cabona ,&nbsp;Chiara Gemelli ,&nbsp;Manuela Vignolo ,&nbsp;Cinzia Maranzana ,&nbsp;Maura Marogna ,&nbsp;Lorenzo Ferrera ,&nbsp;Alessandro Beronio ,&nbsp;Claudio De Michelis ,&nbsp;Valeria Bergamaschi ,&nbsp;Margherita Monti Bragadin ,&nbsp;Giampaolo Brichetto ,&nbsp;Fulvio Braido ,&nbsp;Fabrizio Rao","doi":"10.1016/j.rmed.2025.108003","DOIUrl":"10.1016/j.rmed.2025.108003","url":null,"abstract":"<div><h3>Background</h3><div>Motor neuron diseases (MNDs) encompass amyotrophic lateral sclerosis (ALS), pure/predominant upper (pUMN) and lower motor neuron (pLMN) phenotypes. However respiratory studies have mainly focused on bulbar (B-ALS) and spinal (S-ALS) onset ALS, while little is known in other MNDs. In this study we therefore aimed at characterizing baseline and longitudinal patterns of respiratory involvement and their clinical management in MND patients stratified by their clinical phenotype.</div></div><div><h3>Methods</h3><div>Serial pulmonary function tests (PFTs) (spirometry, arterial blood gas analysis, overnight pulse oximetry and peak cough expiratory flow) records of the MND patients hospitalized between 2020 and 2024 were reviewed. Using longitudinal examinations, deltas of variation in respiratory measures were generated and frequency and timings of non-invasive ventilation (NIV) adaptation were evaluated. Data were compared between phenotypes using the Kruskal–Wallis test with Bonferroni adjustment.</div></div><div><h3>Results</h3><div>42 S-ALS, 105 B-ALS, 42 pLMN and 31 pUMN patients were included. Both at baseline and longitudinally, B-ALS showed the worst respiratory parameters, followed by pLMN, S-ALS and pUMN. NIV adaptation was equally frequent between groups, but earlier in B-ALS compared to pUMN (p = 0.01). At baseline, B-ALS showed worse spirometry and PCEF only, but compared to all the other phenotypes (p from &lt;0.0001 to 0.03). Longitudinally, they conversely exhibited more severe decline in all PFTs, but only relative to pUMN (p from 0.0009 to 0.04), with deltas of variation comparable to the ones observed in S-ALS and pLMN. Among NIV users, more severe PCEF and spirometry impairment further emerged in S-ALS compared to pUMN (p from 0.01 to 0.04).</div></div><div><h3>Conclusions</h3><div>We evidenced convergent trajectories of respiratory decline across B-ALS, S-ALS and pLMN, highlighting the utility of multimodal assessments for tracking progressing respiratory disturbances. These findings have potential to accelerate earlier and more tailored respiratory management across diverse MND phenotypes.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"239 ","pages":"Article 108003"},"PeriodicalIF":3.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising outcomes for adults with cystic fibrosis taking CFTR modulators by individualising care: Personalised data linkage to understand treatment optimisation (PLUTO), a novel clinical framework","authors":"Robert D. Sandler ,&nbsp;Alan Anderson ,&nbsp;Tracy Barnett ,&nbsp;Stephen J. Bourke ,&nbsp;Sarah Cameron ,&nbsp;Stephen J. Chapman ,&nbsp;Jocelyn Choyce ,&nbsp;Thom Daniels ,&nbsp;Tracey Daniels ,&nbsp;Sophie Dawson ,&nbsp;Simon Doe ,&nbsp;Michael Dooney ,&nbsp;Carlos Echevarria ,&nbsp;Penny Galey ,&nbsp;Giles Fitch ,&nbsp;Lana Y.H. Lai ,&nbsp;Julia A. Nightingale ,&nbsp;Michelle Thomas ,&nbsp;Rachael Thompson ,&nbsp;Joanna Whitehouse ,&nbsp;Martin J. Wildman","doi":"10.1016/j.rmed.2025.107995","DOIUrl":"10.1016/j.rmed.2025.107995","url":null,"abstract":"","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"239 ","pages":"Article 107995"},"PeriodicalIF":3.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of traditional Chinese exercise on pulmonary function in middle-aged and older patients with stable chronic obstructive pulmonary disease: A randomized controlled trial","authors":"Ziying Chen ,&nbsp;Hongyu Yue ,&nbsp;Yuanjia Gu ,&nbsp;Chaoqun Xie ,&nbsp;Jianwen Ma ,&nbsp;Fangfang Xie ,&nbsp;Guangdong Wang ,&nbsp;Fei Yao","doi":"10.1016/j.rmed.2025.107997","DOIUrl":"10.1016/j.rmed.2025.107997","url":null,"abstract":"<div><h3>Background</h3><div>Traditional Chinese exercise (TCE) has been shown effective for chronic obstructive pulmonary disease (COPD). However, there are no studies investigating the effect of traditional Chinese exercise (TCE) programme on COPD. The aim of this study was to evaluate the effectiveness of specific TCE programme on the pulmonary function in patients with COPD.</div></div><div><h3>Methods</h3><div>76 patients with COPD was randomly assigned to receive either TCE group or control group in a 1:1 ratio. The primary outcome was changes in forced vital capacity (FVC) from baseline to 12 weeks. Secondary outcomes included forced expiratory volume in the first second (FEV1), tidal volume (VT), inspiratory capacity (IC), expiratory reserve volume (ERV), FEV1/FVC, peak expiratory flow (PEF), the 6-min walking test (6MWT), the COPD Assessment Test (CAT), the Short Form 36-item Health Survey (SF-36), modified medical research council scale (mMRC).</div></div><div><h3>Results</h3><div>After 12 weeks, the TCE group demonstrated a significantly greater improvement of FVC (−12.67; 95 % CI, −18.21 to −7.15; <em>P</em> &lt; 0.001) and FEV1 (−9.70; 95 % CI, −13.73 to −5.68; <em>P</em> &lt; 0.001). But there was no statistically significant difference between groups in FEV1/FVC, PEF, VT, IC or ERV. Besides, patients in the TCE group also reported a statistically significant within-group difference at week 12 in CAT, mMRC and 6MWT. As for eight dimensions of SF-36, patients in TCE group had higher scores in SF-36 (<em>P</em> &lt; 0.05 for 8 dimensions).</div></div><div><h3>Conclusion</h3><div>Our results demonstrate that the traditional Chinese exercise can serve as an effective therapeutic tool for middle-aged and older patients with COPD.</div></div><div><h3>Trial registration number</h3><div>Chinese Clinical Trial Registry, ChiCTR2300069283, <span><span>https://www.chictr.org.cn/showproj.html?proj=192116</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"239 ","pages":"Article 107997"},"PeriodicalIF":3.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143430214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}