Respiratory medicine最新文献

{"title":"Component-resolved diagnostics study on nut sensitization and cross-reactivity in China","authors":"Wenting Luo ,&nbsp;Xianhui Zheng ,&nbsp;Jiale Zhang ,&nbsp;Aoli Li ,&nbsp;Jing Wu ,&nbsp;Jinhai Ma ,&nbsp;Yan Zhao ,&nbsp;Xin Sun ,&nbsp;Chunhua Wei ,&nbsp;Huali Ren ,&nbsp;Siqin Wang ,&nbsp;Hong Zhang ,&nbsp;Yun Sun ,&nbsp;Guoping Li ,&nbsp;Jianxin Sun ,&nbsp;Dongming Huang ,&nbsp;Ting Chen ,&nbsp;Jinni Chen ,&nbsp;Huashou Ke ,&nbsp;Xiangping Ma ,&nbsp;Baoqing Sun","doi":"10.1016/j.rmed.2025.108365","DOIUrl":"10.1016/j.rmed.2025.108365","url":null,"abstract":"<div><h3>Purpose</h3><div>Nut sensitization in China remains insufficiently characterized. Component-resolved diagnosis (CRD) technology offers the ability to distinguish true food allergies from pollen-induced cross-sensitizations while avoiding the risks of oral food challenge (OFC) tests. This study aims to explore and validate the major allergenic components and patterns of cross-reactivity between nuts and pollens in patients with pollen-food allergy syndrome (PFAS).</div></div><div><h3>Methods</h3><div>This study evaluated the sensitization profiles of 104 patients with self-reported PFAS, focusing on crude extracts and major allergenic components of pollen and nuts. In addition, the presence of cross-reactive carbohydrate determinants (CCDs) was tested to determine if the specific immunoglobulin E (sIgE) detection of these plant allergens was influenced by non-specific reactions causing false positives. Furthermore, we conducted serum inhibition assays to explore the cross-reactivity between pollen and nut allergens.</div></div><div><h3>Results</h3><div>The majority of PFAS patients were from northern China, where sensitization to weed pollen, particularly mugwort, was more prevalent than to tree pollen or grass pollens. Hazelnut and walnut were identified as the most frequently sensitizing nut allergens, whereas sensitization rates to other nuts were markedly lower. CRD combined with serum inhibition assays demonstrated a common cross-sensitization between pollen and nut allergens. Notably, the hazelnut component Cor a 1-sIgE was significantly inhibited by birch pollen and its component Bet v 1, while Cor a 8-sIgE showed effective inhibition by mugwort pollen and its component Art v 3.</div></div><div><h3>Conclusions</h3><div>This is the first study to comprehensively evaluate nut sensitization and its key allergenic components in Chinese PFAS patients, confirming substantial cross-sensitization with pollen allergens. Specifically, birch and mugwort pollen significantly inhibited IgE binding to hazelnut. These findings provide component-resolved insights into the prevalence and mechanisms of nut allergies in China, enhancing our understanding of the allergenic landscape and informing clinical diagnosis and management strategies.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108365"},"PeriodicalIF":3.1,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of interstitial lung disease on COVID-19 severity: A nationwide register study","authors":"Emil Ekbom ,&nbsp;Andrei Malinovschi ,&nbsp;Christer Janson ,&nbsp;Lisa Carlson ,&nbsp;Magnus Sköld ,&nbsp;Huiqi Li ,&nbsp;Fredrik Nyberg ,&nbsp;Össur Ingi Emilsson","doi":"10.1016/j.rmed.2025.108372","DOIUrl":"10.1016/j.rmed.2025.108372","url":null,"abstract":"<div><h3>Aim</h3><div>To investigate if ILD is associated with increased severity of COVID-19 and if this association differs by disease type or vaccination status.</div></div><div><h3>Methods</h3><div>Data from Swedish national registers within the SCIFI-PEARL study was used to examine the relationship between ILD and three levels of COVID-19 severity: non-hospitalized, hospitalized, and critical (ICU admission or death) from January 2020 to May 2022. We performed multinomial logistic regression, adjusted for confounding factors, and examined interactions with vaccination status.</div></div><div><h3>Results</h3><div>Altogether, 18,666 patients with ILD were included, comprising 8774 with fibrotic ILD and 9181 with sarcoidosis. Among ILD patients with COVID-19 (n = 3384), 18.9 % required hospitalization and 8.5 % had critical disease, compared to 3.8 % and 1.3 % respectively, among COVID-19 patients without ILD. ILD was associated with increased severity of COVID-19 compared to patients without ILD (Conditional Odds Ratio (COR) (95 % CI)): hospitalization 2.30 (2.09–2.54), critical disease 2.50 (2.17–2.88)). Corresponding CORs were 3.25 (2.81–3.75) and 3.46 (2.88–4.15) for fibrotic ILD, and 1.56 (1.34–1.81) and 1.57 (1.21–2.03) for sarcoidosis.</div><div>Two or more vaccine doses protected against severe COVID-19 among patients with ILD and COVID-19, reducing hospitalizations (non-vaccinated: 21.8 %; vaccinated: 16.3 %), and an even stronger reduction in critical disease (non-vaccinated: 12.0 %; vaccinated: 3.6). However, even among fully vaccinated individuals, ILD remained significantly associated with increased severity of COVID-19.</div></div><div><h3>Conclusions</h3><div>ILD is associated with increased COVID-19 severity in patients with infection, particularly in patients with fibrotic ILD. Vaccination most effectively prevents critical illness. Our study underscores the continued importance of vaccination programs and preventive strategies.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108372"},"PeriodicalIF":3.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between empiric multidrug-resistant coverage and in-hospital mortality in adults with sepsis who received empiric anti-MRSA therapy","authors":"Toshikazu Abe ,&nbsp;Hiroki Iriyama ,&nbsp;Taro Imaeda ,&nbsp;Takehiko Oami ,&nbsp;Tuerxun Aizimu ,&nbsp;Nozomi Takahashi ,&nbsp;Yasuo Yamao ,&nbsp;Satoshi Nakagawa ,&nbsp;Hiroshi Ogura ,&nbsp;Yutaka Umemura ,&nbsp;Asako Matsushima ,&nbsp;Kiyohide Fushimi ,&nbsp;Nobuaki Shime ,&nbsp;Taka-aki Nakada","doi":"10.1016/j.rmed.2025.108366","DOIUrl":"10.1016/j.rmed.2025.108366","url":null,"abstract":"<div><h3>Purpose</h3><div>The aim of this study was to investigate the association between empiric MDR coverage and in-hospital mortality among adults with sepsis who received empiric <em>anti</em>-MRSA therapy.</div></div><div><h3>Materials and methods</h3><div>This was a nested case‒control study using Japanese nationwide data from a medical reimbursement system between 2010 and 2017. Patients with sepsis and using empiric antimicrobials with MRSA coverage were extracted. Among them, we enrolled patients with MDR coverage and those without MDR coverage via propensity score matching on the basis of their baseline characteristics.</div></div><div><h3>Results</h3><div>Both the MDR coverage cohort and the non-MDR coverage cohort each comprised 6,068 patients. The MDR coverage group had more acute organ dysfunction than the non-MDR coverage group did (moderate: 34.0 % vs. 24.3 %; severe: 5.0 % vs. 2.7 %, p &lt; 0.001). The MDR coverage group had significantly higher crude in-hospital mortality than the non-MDR coverage group did (22.9 % vs. 16.7 %, p &lt; 0.001). The conditional logistic regression model revealed that MDR coverage and acute organ dysfunction were significantly associated with in-hospital mortality. The interaction between MDR coverage and severe acute organ dysfunction was statistically significant (p for interaction = 0.02). Stratified by severity, in-hospital mortality rates were reversed between moderate and severe (in-hospital mortality rates: mild 16.4 % vs. 12.3 %; moderate 31.6 % vs. 26.7 %; and severe 42.3 % vs. 44.8 %).</div></div><div><h3>Conclusions</h3><div>Our study revealed that empiric concomitant MDR coverage might be considered for adults with sepsis who received empiric <em>anti</em>-MRSA therapy if they have multiple acute organ dysfunctions, although their population is small.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108366"},"PeriodicalIF":3.1,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of a 12-week tele-exercise using immersive virtual reality on functional capacity in adolescents with cystic fibrosis: A randomized controlled, single (assessor) - blind study","authors":"Ozden Ozyemisci Taskiran ,&nbsp;Havvanur Albayrak ,&nbsp;Can Kog ,&nbsp;Ecenur Atli ,&nbsp;Erdem Gonullu ,&nbsp;Asim Evren Yantac ,&nbsp;Zeynep Seda Uyan","doi":"10.1016/j.rmed.2025.108362","DOIUrl":"10.1016/j.rmed.2025.108362","url":null,"abstract":"<div><h3>Background</h3><div>Adolescents with cystic fibrosis (CF) have lower levels of physical activity compared to their peers. Risk of cross-contamination limits participation in face-to-face sport activities. Tele-exercise (TE) is a good alternative to deliver exercise remotely, without risk of infection. Immersive virtual reality (VR) could be a motivating method to improve the functional capacity. The primary aim was to evaluate the effect of a 12-week VR exercises on 6-min walk distance (6MWD). The secondary aims were to assess its effects on pulmonary function, muscle strength, quality of life, feasibility, and enjoyment.</div></div><div><h3>Methods</h3><div>In this randomized controlled study, clinically stable participants aged between 12 and 18 years were included and randomized to a VR-based tele-exercise (VR-TE) or a TE group. Exercises were conducted in groups of 6 participants for 30 min, 3 days/week for 12 weeks in both groups. Outcome measures were 6MWD, FEV₁, hand grip, shoulder flexor and knee extensor muscle strength, Cystic Fibrosis Questionnaire Revised (CFQ-R), physical activity enjoyment scale and system usability scale.</div></div><div><h3>Results</h3><div>Twenty-one participants completed the study. Baseline pulmonary function tests, 6MWD, muscle strength, and CFQ-R scores were similar between groups. In the VR-TE group, post-training 6MWD was significantly higher than pre-training 6MWD (z = −2.93, p = 0.003). However, no statistical improvement was observed in pulmonary function, muscle strength, or quality of life. Feasibility, enjoyment, adherence, and adverse effects were similar between groups.</div></div><div><h3>Conclusion</h3><div>Virtual reality and tele-exercise are feasible and motivating methods to facilitate the participation in exercise and improve functional capacity in adolescents with CF. Longer duration of VR-based exercise might be needed to improve muscle strength and quality of life.</div></div><div><h3>Clinical trials registration number</h3><div>NCT05850351.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108362"},"PeriodicalIF":3.1,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram model to predict in-hospital mortality in lung transplant recipients: A retrospective cohort study","authors":"Sangsang Qiu ,&nbsp;Qinfen Xu ,&nbsp;Qinhong Huang ,&nbsp;Bo Wu ,&nbsp;Hang Yang ,&nbsp;Lingzhi Shi ,&nbsp;Yuqing Gong ,&nbsp;Jianming Wang ,&nbsp;Jingyu Chen ,&nbsp;Xiaojun Cai","doi":"10.1016/j.rmed.2025.108369","DOIUrl":"10.1016/j.rmed.2025.108369","url":null,"abstract":"<div><h3>Purpose</h3><div>Lung transplantation (LTx) is a vital treatment for advanced lung disease. However, in-hospital mortality remains a significant challenge. Identifying perioperative risk factors is crucial for improving outcomes. This study aimed to develop a predictive nomogram for in-hospital mortality in lung transplant recipients.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 1355 LTx recipients at Wuxi People's Hospital (2015–2024). Least absolute shrinkage and selection operator (LASSO) regression identified predictors of in-hospital mortality. A nomogram was constructed and validated using calibration curves, decision curve analysis, and receiver operating characteristic (ROC) curves.</div></div><div><h3>Findings</h3><div>The overall in-hospital mortality rate was 14.5 %, with deaths occurring within 20 days post-surgery. Independent predictors included age, ICU stay duration, cold ischemia time, blood transfusion, C-reactive protein, serum sodium, primary graft dysfunction, renal replacement therapy, and extracorporeal membrane oxygenation support. The nomogram showed superior predictive accuracy (AUROC: 0.874, 95 % CI 0.843–0.905) compared to SOFA (AUROC: 0.772, 95 % CI 0.732–0.812) and APACHE II scores (AUROC: 0.718, 95 % CI 0.673–0.764). Calibration and decision curve analyses confirmed its accuracy and clinical utility.</div></div><div><h3>Conclusions</h3><div>This study highlights key perioperative risk factors for in-hospital mortality in LTx recipients. The developed nomogram provides a reliable tool for predicting early mortality, aiding clinicians in optimizing patient management.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108369"},"PeriodicalIF":3.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145099508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyspnea-related kinesiophobia as a barrier on cystic fibrosis: The role of children and parents","authors":"Vildan Fidanoglu ,&nbsp;Zeynep Selcuk ,&nbsp;Seda Saka ,&nbsp;Erkan Cakir","doi":"10.1016/j.rmed.2025.108364","DOIUrl":"10.1016/j.rmed.2025.108364","url":null,"abstract":"<div><h3>Background</h3><div>Children with cystic fibrosis (CF) may be physically inactive due to disease progression and infection risk, with parents sometimes being overly protective. This study aimed to explore the relationship between dyspnea-related kinesiophobia in children and their parents and the child's respiratory muscle strength, physical activity, fitness, and quality of life.</div></div><div><h3>Methods</h3><div>Fourty-three children with CF (21 females, 22 males, 11.02 ± 3.24 years) and their caregivers (34 mothers, eight fathers, one cousin; 39.45 ± 6.76 years) included. Children underwent spirometry, respiratory muscle strength tests (maximal inspiratory pressure-MIP, maximal expiratory pressure-MEP), the Pediatric Physical Activity Questionnaire (PAQ-C), Munich Physical Fitness Test (MFT), Breathless Beliefs Questionnaire (BBQ), Cystic Fibrosis Questionnaire-Revised (CFQ-R). Parents completed the Breathless Beliefs Questionnaire-Caregiver Version (BBQ-C), Fear of Disease Progression Questionnaire (FoP), CFQ-R-Caregiver Version. Pearson's correlation coefficient was used for analysis.</div></div><div><h3>Results</h3><div>The mean BBQ score of children with CF was 28.62 ± 10.76. The BBQ was correlated with MIP%, MEP, MEP%, and CFQ-R subscales (p &lt; 0.05). The mean BBQ-C score for parents was 28.06 ± 9.85. The BBQ-C was correlated with PAQ-C, MFT, FoP, and CFQ-R subscales (p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Children with CF and their parents show high levels of dyspnea-related kinesiophobia. In children, it was associated with lower respiratory muscle strength and reduced quality of life, while parental dyspnea-related kinesiophobia was more strongly associated with the child's physical activity, fitness, quality of life. Parental dyspnea-related kinesiophobia may be more closely related to the child's functional abilities than the child's dyspnea-related kinesiophobia, highlighting the potential value of addressing psychosocial factors in CF rehabilitation.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108364"},"PeriodicalIF":3.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145099507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of static compliance of the respiratory system based on anthropometric measurements in patients on mechanical ventilation: a cross-sectional pragmatic study","authors":"Helder Brito Duarte ,&nbsp;Leonardo José Morais Santos ,&nbsp;José da Natividade Menezes Júnior ,&nbsp;Tainã de Jesus Cerqueira Santos ,&nbsp;Thainá Regina dos Santos ,&nbsp;Renan Luiz de Oliveira Reiz ,&nbsp;Camilla de Souza Menezes ,&nbsp;Dimitri Gusmao-Flores ,&nbsp;Bruno Prata Martinez","doi":"10.1016/j.rmed.2025.108368","DOIUrl":"10.1016/j.rmed.2025.108368","url":null,"abstract":"<div><h3>Introduction</h3><div>Standard values for static compliance of the respiratory system (Crs) ranging from 50 to 70 ml/cmH₂O lack population-specific data and may be influenced by anthropometry.</div></div><div><h3>Objective</h3><div>Describe Crs in ICU patients, evaluate its relationship with predicted body weight (PBW), and develop a predictive model for individualized Crs reference values based on anthropometric variables.</div></div><div><h3>Methods</h3><div>A multicenter cross-sectional study was conducted across Brazil, involving mechanically ventilated patients. Individuals with hemodynamic instability, chest wall deformities, or intrathoracic limitations were excluded. Data collected included PBW, plateau pressure, Crs, and Driving Pressure (DP). Patients were categorized into high Crs (≥0.60 ml/cmH₂O/kg) and low Crs (&lt;0.60 ml/cmH₂O/kg).</div></div><div><h3>Results</h3><div>The study included 147 patients with mean values of Crs (38.0 ± 11.2 ml/cmH₂O), DP (10.0[8.0–11.2] cmH2O), and Crs/PBW (0.62 ± 0.1 ml/cmH₂O/kg). Between high and low Crs groups has observed statistically differences in Crs and DP values. Additionally, Crs also showed correlation with the variables age, height, PBW, Ppeak, and Pplat. Thus, it can be understood that height directly influences Crs, especially in patients with high Crs lungs. A multiple linear regression model using height, age, and sex as predictors was fitted to estimate Crs in patients with high Crs lungs, yielding an R² of 0.567 with p &lt; 0,01.</div></div><div><h3>Conclusion</h3><div>Our study indicated that Crs in mechanically ventilated patients with near-normal elastance is associated with anthropometric data, particularly height and sex. A Crs/PBW cutoff of 0.6 ml/cmH2O/kg was established. The study also presents a preliminary model for Crs prediction.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108368"},"PeriodicalIF":3.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferritin-to-albumin ratio predicts short-term mortality in critically ill patients with non-COVID-19 Pneumonia: A retrospective cohort study from MIMIC-IV database","authors":"Juan Feng ,&nbsp;Tianhang Zhao ,&nbsp;Yiyang Huang ,&nbsp;Sien Lai ,&nbsp;Guojun Chen","doi":"10.1016/j.rmed.2025.108361","DOIUrl":"10.1016/j.rmed.2025.108361","url":null,"abstract":"<div><h3>Background</h3><div>Community-acquired and hospital-acquired pneumonia significantly contribute to global morbidity and mortality, necessitating reliable prognostic biomarkers. The ferritin-to-albumin ratio (FAR), integrating inflammatory and nutritional markers, demonstrates prognostic value in COVID-19 pneumonia but remains underexplored in non-COVID-19 pneumonia.</div></div><div><h3>Methods</h3><div>This retrospective cohort study analyzed 827 non-COVID-19 pneumonia patients from the MIMIC-IV database. FAR was calculated using admission ferritin and albumin levels, with patients stratified into tertiles (Q1-Q3). Cox proportional hazards models assessed associations between FAR and 28-day/90-day mortality, adjusted for demographics, comorbidities, laboratory parameters, and disease severity scores.</div></div><div><h3>Results</h3><div>Higher FAR tertiles exhibited significantly increased 28-day and 90-day mortality rates (both P &lt; 0.05). After comprehensive adjustment, the highest FAR tertile (Q3) had a 2.27-fold higher 28-day mortality risk (HR: 2.27, 95 % CI: 1.44–3.58, <em>P</em> &lt; 0.001) and 1.82-fold higher 90-day mortality risk (HR: 1.82, 95 % CI: 1.27–2.61, <em>P</em> = 0.001) compared to Q1. Each log2-unit FAR increase independently raised 28-day and 90-day mortality risks by 17 % (HR: 1.17, 95 % CI: 1.06–1.29, P = 0.002) and 14 % (HR: 1.14, 95 % CI: 1.06–1.24, <em>P</em> = 0.001), respectively. FAR's prognostic consistency across subgroups confirmed its robustness.</div></div><div><h3>Conclusion</h3><div>FAR at admission serves as a robust, independent predictor of short- and intermediate-term mortality in non-COVID-19 pneumonia. By synergistically reflecting hyperinflammation and physiological reserve depletion, FAR provides enhanced prognostic utility over isolated biomarkers, offering a cost-effective tool for risk stratification. Prospective validation is warranted to confirm its clinical applicability and explore FAR-guided therapeutic interventions.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108361"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors for complications of foreign body aspiration in children","authors":"Wen-yuan Wang,&nbsp;Shu-ying Wang,&nbsp;Qi-jun Zhao,&nbsp;Wan-yi Li,&nbsp;Tao Zhang,&nbsp;Yong-jun Wang","doi":"10.1016/j.rmed.2025.108363","DOIUrl":"10.1016/j.rmed.2025.108363","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to investigate risk factors associated with complications of Foreign Body Aspiration in children, providing reference for clinical prevention and treatment.</div></div><div><h3>Methods</h3><div>Clinical data from 951 pediatric patients with Foreign Body Aspiration admitted to Gansu Provincial Maternal and Child-care Hospital between January 2017 and December 2021 were retrospectively analyzed. Patients were categorized into complication-free and complication groups based on occurrence of complications. Univariate and multivariate binary logistic regression analyses were performed to identify risk factors associated with complications.</div></div><div><h3>Result</h3><div>Multivariate analysis revealed that right-sided foreign bodies (OR = 4.452, 95 % CI: 1.084–18.283, P = 0.038) and confirmed history of inhalation (OR = 1.767, 95 % CI: 1.121–2.787, P = 0.014) were independent risk factors for complications. while glottic foreign bodies (OR = 0.657, 95 % CI: 0.472–0.915, P = 0.013), foreign body duration ≤1 day (OR = 0.256, 95 % CI: 0.114–0.573, P = 0.001), urban residence (OR = 0.564, 95 % CI: 0.387–0.823, P = 0.003), and foreign body occurrence in autumn (OR = 0.596, 95 % CI: 0.366–0.972, P = 0.038) were protective factors. Foreign body type, quantity, and CT confirmation status showed no significant impact on complication occurrence (P &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Right-sided foreign bodies and a clear history of aspiration increase the risk of complications, whereas glottic foreign bodies, early diagnosis and treatment, urban residence, and foreign body ingestion in autumn exert protective effects. Clinicians should prioritize high-risk pediatric patients, enhance early diagnosis and intervention to reduce the risk of complications.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108363"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145099506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problem analysis based on the international classification of functioning, disability and health (ICF) in patients with Takayasu arteritis","authors":"Elif Gur Kabul ,&nbsp;Sinem Bozcuk ,&nbsp;Bilge Basakci Calik ,&nbsp;Ayse Nur Bayındır Akbas ,&nbsp;Veli Cobankara","doi":"10.1016/j.rmed.2025.108354","DOIUrl":"10.1016/j.rmed.2025.108354","url":null,"abstract":"<div><h3>Background</h3><div>Existing research on Takayasu arteritis has mainly focused on clinical, radiological, and immunological aspects, leaving a significant gap in understanding its functional, psychosocial, and multidimensional impact due to the absence of a disease-specific International Classification of Functioning, Disability, and Health (ICF) framework. This study aimed to analyze the problems of patients with Takayasu arteritis using a phenomenological approach based on the ICF.</div></div><div><h3>Methods</h3><div>A qualitative study was conducted with patients diagnosed with Takayasu arteritis. Eighteen patients were asked six open-ended questions. Their responses were audio-recorded and later transcribed. The responses were divided into meaningful units and linked to the most precise ICF categories by two independent health professionals. To evaluate the appropriateness of the linked ICF categories, sixteen rheumatologists were asked to indicate whether each category represented patients' problems, resources, or environmental aspects.</div></div><div><h3>Results</h3><div>Patients' responses were linked to 122 ICF categories by the two health professionals, with a kappa coefficient of 0.774 indicating substantial agreement. Sixteen rheumatologists reviewed the linked categories through two rounds and a mini-Delphi process. Ultimately, 74 ICF categories were confirmed for the Takayasu arteritis Core Set with ≥75 % agreement. Forty-eight patient-identified categories were not confirmed by the rheumatologists (&lt;75 % agreement).</div></div><div><h3>Conclusions</h3><div>The content validity of the ICF Core Set for Takayasu arteritis was supported by expert rheumatologists. This ICF Core Set can be applied to the evaluation of patients with Takayasu arteritis.</div></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":"248 ","pages":"Article 108354"},"PeriodicalIF":3.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}