Respiratory medicine最新文献_第7页

An update on the minimally invasive diagnosis of lymphoma for the chest physicians 为胸科医生提供的淋巴瘤微创诊断最新信息。

IF 3.5 3区医学

Respiratory medicine Pub Date : 2024-08-23 DOI: 10.1016/j.rmed.2024.107765

Ronaldo Ortiz-Pacheco , Tejas Sinha , Christian Ghattas , Jasleen Pannu , Jason Willis , Alberto Revelo , Nicholas Pastis

{"title":"An update on the minimally invasive diagnosis of lymphoma for the chest physicians","authors":"Ronaldo Ortiz-Pacheco , Tejas Sinha , Christian Ghattas , Jasleen Pannu , Jason Willis , Alberto Revelo , Nicholas Pastis","doi":"10.1016/j.rmed.2024.107765","DOIUrl":"10.1016/j.rmed.2024.107765","url":null,"abstract":"<div><p>Mediastinal lymphadenopathy has a broad differential diagnosis which includes lymphoma. The current preferred biopsy technique for mediastinal lymph nodes is transbronchial needle aspiration which has mixed results in terms of sensitivity, specificity and diagnostic yields; there are also limitations with subtyping lymphomas with needle aspiration alone which can be a barrier to determine management strategies. Invasive mediastinal lymph node sampling such was with mediastinoscopy provides higher yields and preserved lymph node architecture for both diagnosis and subtyping of lymphoma but carries a higher risk of morbidity and complications. Novel techniques that may increase the diagnostic yield of bronchoscopy in the diagnosis of lymphoma are core biopsy needles, intranodal forcep biopsy, and intranodal cryobiopsy. The evidence is limited due to a relatively small number of cases, so further research is needed to standardize best practices for the bronchoscopic diagnosis of lymphoma.</p><p>Pleural effusions in lymphoma can be present in up to 30 % of cases with the majority being non-Hodgkins's lymphoma. The presence of exudative effusion in the setting of an existing or prior diagnosis of lymphoma should raise clinical suspicions. Other less common subtypes of lymphoma presenting as primary pleural effusions are explored as well.</p></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and etiotypes of persistent airflow obstruction in the general population across the lifetime 普通人群一生中持续性气流阻塞的患病率和病因类型。

IF 3.5 3区医学

Respiratory medicine Pub Date : 2024-08-22 DOI: 10.1016/j.rmed.2024.107779

M.T. Grasl , A. Agusti , M. Azizzadeh , A. Karimi , S. Hartl , M.-K. Breyer , R. Breyer-Kohansal

{"title":"Prevalence and etiotypes of persistent airflow obstruction in the general population across the lifetime","authors":"M.T. Grasl , A. Agusti , M. Azizzadeh , A. Karimi , S. Hartl , M.-K. Breyer , R. Breyer-Kohansal","doi":"10.1016/j.rmed.2024.107779","DOIUrl":"10.1016/j.rmed.2024.107779","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Different factors (etiotypes) can lead to persistent airflow obstruction (PAO) across the lifetime, including genetic factors, abnormal lung development, cigarette smoking, traffic pollution exposure, respiratory infections and asthma. Here we explore the prevalence of PAO and associated etiotypes in the general population in different age bins.</p></div><div><h3>Methods</h3><p>We studied 664 individuals with PAO (FEV1/FVC post bronchodilation (post-BD) below the lower limit of normal (LLN)) and 11,522 with normal lung function (FEV1/FVC, FEV1 and FVC ≥ LLN and ≤ upper limit of normal (ULN) post-BD) included in the LEAD Study (NCT01727518), a general population cohort in Vienna (Austria). For analysis, participants were stratified in three age bins (<25, 25-<50 and ≥ 50 years of age).</p></div><div><h3>Results</h3><p>PAO occurred in 3.8 % in females and 5.6 % in males of the cohort, and it increased with age. Most participants with PAO (57.5 %) reported respiratory symptoms, indicating a high burden of disease. PAO was associated with male sex (25-<50 years), ever smoking (>50 years), increased number of pack years (25-<50 years, >50 years), not being breastfed (<25 years) and ever diagnosis of asthma (in all age bins). Etiotypes varied by age bins with cigarette smoking being the most prevalent one, often in combination with traffic pollution exposure.</p></div><div><h3>Conclusion</h3><p>In the general population PAO occurs in about 5 % of participants with a higher prevalence in older individuals. Etiotypes and associated factors for PAO accumulate with age.</p></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phase angle measured by bioelectrical impedance analysis in patients with chronic obstructive pulmonary disease: Associations with physical inactivity and frailty 通过生物电阻抗分析测量慢性阻塞性肺病患者的相位角：与缺乏运动和体质虚弱的关系。

IF 3.5 3区医学

Respiratory medicine Pub Date : 2024-08-22 DOI: 10.1016/j.rmed.2024.107778

Ryota Hamada , Naoya Tanabe , Yohei Oshima , Yuji Yoshioka , Tomoki Maetani , Yusuke Shiraishi , Atsuyasu Sato , Susumu Sato , Ryosuke Ikeguchi , Shuichi Matsuda , Toyohiro Hirai

{"title":"Phase angle measured by bioelectrical impedance analysis in patients with chronic obstructive pulmonary disease: Associations with physical inactivity and frailty","authors":"Ryota Hamada , Naoya Tanabe , Yohei Oshima , Yuji Yoshioka , Tomoki Maetani , Yusuke Shiraishi , Atsuyasu Sato , Susumu Sato , Ryosuke Ikeguchi , Shuichi Matsuda , Toyohiro Hirai","doi":"10.1016/j.rmed.2024.107778","DOIUrl":"10.1016/j.rmed.2024.107778","url":null,"abstract":"<div><h3>Background</h3><p>Factors associated with early-stage frailty (pre-frailty) in patients with chronic obstructive pulmonary disease (COPD) remain unestablished. In addition to skeletal muscle quantity, skeletal muscle dysfunction can be estimated using an angular metric from bioelectrical impedance analyzer (BIA), termed the phase angle, that reflects cell membrane reactance representing the structural stability. This study examined whether the phase angle was more closely associated with pre-frailty compared with skeletal muscle quantity in patients with COPD.</p></div><div><h3>Methods</h3><p>This cross-sectional analysis included stable smokers with and without COPD whose frailty status was assessed using the Japanese version of the Cardiovascular Health Study criteria. The phase angle and skeletal muscle index (SMI) were measured using BIA, and physical activity over one week was assessed using triaxial accelerometers.</p></div><div><h3>Results</h3><p>A total of 159 patients were categorized into robust, pre-frail, and frail groups (n = 38, 92, and 29, respectively). The phase angle was significantly smaller in the pre-frail and frail groups than in the robust group after adjusting for age, sex, height, body mass index, smoking history, and lung function. In contrast, SMI did not differ between the robust and pre-frail groups. When combining the pre-frail and frail groups into a non-robust group, 4.8° was determined as the cutoff phase angle value to identify non-robust status. A phase angle <4.8° was associated with shorter durations of moderate-intensity physical activity but not with light physical activity.</p></div><div><h3>Conclusions</h3><p>A smaller phase angle was associated with pre-frailty and impaired moderate-intensity physical activity in smokers with and without COPD.</p></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choosing the right biologic treatment for individual patients with severe asthma – Lessons learnt from Picasso 为重症哮喘患者选择合适的生物制剂治疗--从毕加索身上吸取的教训。

IF 3.5 3区医学

Respiratory medicine Pub Date : 2024-08-22 DOI: 10.1016/j.rmed.2024.107766

Milan Terl , Zuzana Diamant , Radovan Kosturiak , Milos Jesenak

{"title":"Choosing the right biologic treatment for individual patients with severe asthma – Lessons learnt from Picasso","authors":"Milan Terl , Zuzana Diamant , Radovan Kosturiak , Milos Jesenak","doi":"10.1016/j.rmed.2024.107766","DOIUrl":"10.1016/j.rmed.2024.107766","url":null,"abstract":"<div><p>Severe asthma represents a true challenge for clinicians from two basic perspectives, <em>i.e.</em>: a rational assessment of the underlying endo/phenotype and the subsequent selection of the best fitted (personalized) and effective treatment. Even though asthma is a heterogeneous disease, in the majority of therapy-compliant patients, it is possible to achieve (almost) complete disease control or even remission through conventional and quite uniform step-based pharmacotherapy, even without phenotyping. However, the absence of deeper assessment of individual patients revealed its handicap to its fullest extent during the first years of the new millennium upon the launch of biological therapeutics for patients with the most severe forms of asthma. The introduction of differentially targeted biologics into clinical practice became a challenge in terms of understanding and recognizing the etiopathogenetic heterogeneity of the asthmatic inflammation, pheno/endotyping, and, consequently, to choose the right biologic for the right patient.</p><p>The answers to the following three questions should lead to correct identification of the dominant pheno/endotype: Is it really (severe) asthma? Is it eosinophilic asthma? If eosinophilic, is it (predominantly) allergen-driven? The identification of the best achievable and relevant alliance between endotypes and phenotypes (“euphenotypes”) should be based not only on the assessment of the actual clinical characteristics and laboratory biomarkers, but more importantly, on the evaluation of their development and changes over time.</p><p>In the current paper, we present a pragmatic three-step approach to severe asthma diagnosis and management.</p></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and prognostic value of malnutrition in patients with IPF using three scoring systems 使用三种评分系统评估 IPF 患者营养不良的患病率和预后价值

IF 3.5 3区医学

Respiratory medicine Pub Date : 2024-08-19 DOI: 10.1016/j.rmed.2024.107774

Qinxue Shen , Shiting Zhou , Min Song , Xiaoli Ouyang , Yuexin Tan , Yating Peng , Zijing Zhou , Hong Peng

{"title":"Prevalence and prognostic value of malnutrition in patients with IPF using three scoring systems","authors":"Qinxue Shen , Shiting Zhou , Min Song , Xiaoli Ouyang , Yuexin Tan , Yating Peng , Zijing Zhou , Hong Peng","doi":"10.1016/j.rmed.2024.107774","DOIUrl":"10.1016/j.rmed.2024.107774","url":null,"abstract":"<div><h3>Background</h3><p>To describe the nutritional status of IPF patients, report clinical associations and evaluate the prognostic value of them in IPF.</p></div><div><h3>Methods</h3><p>264 IPF patients diagnosed with IPF at the Second Xiangya Hospital of Central South University between January 2011 and January 2021 were recruited. Three different scoring systems, including nutritional risk index (NRI), controlling nutritional status (CONUT) score, and prognostic nutritional index (PNI) were used to describe the nutritional status of IPF patients.</p></div><div><h3>Result</h3><p>This study investigated the prevalence of malnutrition in 264 IPF patients, of which the percentage with malnutrition varied from 37.5 % with the NRI, to 47.4 % with the CONUT score, and to 6.4 % with the PNI. The moderate to severe malnutrition ranged from 10.2 % to 31.1 % across these indices, with PNI identifying only 4.9 % in this category. Worsening malnutrition status was associated with significantly higher incidence of all-cause mortality and IPF death regard of the malnutrition index as NRI (p < 0.05). When the normal nutrition of NRI was used as a reference, patients in the moderate to severe risk remained at a higher risk of all-cause death (HR = 2.06(1.25–3.41)) and IPF death(HR = 2.36(1.35–4.15)). The adjusted multivariate analysis, identified age(HR = 1.13(1.08–1.20)), DLCO <60, % predicted (HR = 3.31(1,24–9.42)) and the use of anti-fibrotic drugs (HR = 0.25(0.10–0.60)) as independent predictors of mortality.</p></div><div><h3>Conclusions</h3><p>Malnutrition is common among patients with IPF and the baseline as diagnosis of IPF is strongly related to increased mortality.</p></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma catecholamines in patients undergoing invasive cardiopulmonary exercise test for exercise intolerance 因运动不耐受而接受侵入性心肺运动试验的患者的血浆儿茶酚胺。

IF 3.5 3区医学

Respiratory medicine Pub Date : 2024-08-13 DOI: 10.1016/j.rmed.2024.107775

Abdelrahman Nanah , Marcos V.F. Garcia , James Lane , Deborah Paul , Adriano R. Tonelli

{"title":"Plasma catecholamines in patients undergoing invasive cardiopulmonary exercise test for exercise intolerance","authors":"Abdelrahman Nanah , Marcos V.F. Garcia , James Lane , Deborah Paul , Adriano R. Tonelli","doi":"10.1016/j.rmed.2024.107775","DOIUrl":"10.1016/j.rmed.2024.107775","url":null,"abstract":"<div><h3>Background</h3><p>Invasive cardiopulmonary exercise testing (iCPET) combines traditional cardiopulmonary exercise testing with invasive hemodynamic measurements to assess exercise intolerance, which can be caused by preload insufficiency (PI), characterized by low ventricular filling pressures and reduced cardiac output during exertion. We hypothesize that plasma catecholamine levels at rest and during exercise correlate with hemodynamic parameters in PI.</p></div><div><h3>Methods</h3><p>We included adult patients who underwent iCPET for exercise intolerance and had plasma catecholamines measured at rest and peak exercise.</p></div><div><h3>Results</h3><p>Among 84 patients, PI was identified in 57 (67.8 %). Compared to patients without PI, those with PI were younger [median (IQR) 37 (28, 46) vs 47 (39,55) years, p = 0.005] and had lower workload at peak exercise [81 (66, 96) vs 95 (83.5, 110.50) Watts, p = 0.006]. Patients with PI had higher heart rates at rest and peak exercise [87 (78, 97) vs 79 (74, 87) bpm, p = 0.04; and 167 (154, 183) vs 156 (136, 168) bpm, p = 0.01, respectively]. In all patients, epinephrine and norepinephrine at peak exercise directly correlated with peak workload (r:0.41, p < 0.001 and r:0.47, p < 0.001, respectively). Resting epinephrine was higher in patients with PI [136 (60, 210) vs 77 (41, 110) pg/mL, p = 0.02]. There was no significant difference in the change in catecholamines from rest to peak exercise between patients with or without PI.</p></div><div><h3>Conclusion</h3><p>PI patients exhibited elevated heart rate and epinephrine at rest, indicating increased sympathetic activity. We did not find strong associations between catecholamines and cardiac filling pressures, suggesting that catecholamine levels are predominantly influenced by peak workload.</p></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of the interventionalist's sex on the outcome and complications of transbronchial lung cryobiopsy 介入医师的性别对经支气管肺冷冻活组织检查结果和并发症的影响。

IF 3.5 3区医学

Respiratory medicine Pub Date : 2024-08-13 DOI: 10.1016/j.rmed.2024.107772

Franziska C. Trudzinski , Christos Athanasiou , Ralf Eberhardt , Julia D. Michels-Zetsche , Mavi Schellenberg , Monika Eichinger , Markus Polke , Kathrin Kahnert , Felix J.F. Herth , Michael Kreuter , Konstantina Kontogianni

{"title":"The influence of the interventionalist's sex on the outcome and complications of transbronchial lung cryobiopsy","authors":"Franziska C. Trudzinski , Christos Athanasiou , Ralf Eberhardt , Julia D. Michels-Zetsche , Mavi Schellenberg , Monika Eichinger , Markus Polke , Kathrin Kahnert , Felix J.F. Herth , Michael Kreuter , Konstantina Kontogianni","doi":"10.1016/j.rmed.2024.107772","DOIUrl":"10.1016/j.rmed.2024.107772","url":null,"abstract":"<div><h3>Background</h3><p>To date there are no data on sex aspects evaluating outcomes of interventional pneumology (IP). Our aim was to investigate sex differences in transbronchial lung cryobiopsy (TBLC) outcomes in the diagnosis of interstitial lung disease (ILD).</p></div><div><h3>Methods</h3><p>All consecutive (TBLC)s performed for ILD evaluation between Nov 17 and Dec 21 at a tertiary referral center for ILDs and IP were analyzed. The indication for the procedure was determined by a multidisciplinary discussion (MDD). Final results including bronchoalveolar lavage (BAL) and histology were discussed in a 2nd MDD and outcomes and procedure related complications were assessed.</p></div><div><h3>Results</h3><p>TBLC was performed in 406 patients (38.4 % female/67.8 years/FVC 76.8 %). Among 32 interventionalists, 16 females performed 53 % of interventions. Females had longer procedure times (29.9 vs. 26.6 min, p = 0.046), used fluoroscopy more often (76.7 vs. 50.3 %, p < 0.001) and obtained more samples (3.6 vs. 3.2, p = 0.021) than their male counterparts. No difference was found for major bleeding or pneumothorax. MDD was able to conclude on a diagnosis in 88.4 % of interventions performed by women and in 78.5 % performed by men (p = 0.010). In a multivariate analysis, female gender (OR 1.93) and lower FVC% values (OR 0.98) were significantly associated with diagnostic yield, whereas the number of biopsies, professional experience, use of fluoroscopy or antiplatelet drugs were not relevant.</p></div><div><h3>Conclusion</h3><p>The results of this study strengthen the role of women in endoscopy and may help to motivate women to pursue a career in IP.</p></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary patterns and risk of Chronic Obstructive Pulmonary Disease (COPD) and clinical outcomes in diagnosed patients: A scoping review 膳食模式与慢性阻塞性肺病（COPD）风险及确诊患者的临床疗效：范围界定综述。

IF 3.5 3区医学

Respiratory medicine Pub Date : 2024-08-13 DOI: 10.1016/j.rmed.2024.107773

Carolina Ignacio Carlotto , Simone Bernardes , Priscilla Zanella , Flávia Moraes Silva

{"title":"Dietary patterns and risk of Chronic Obstructive Pulmonary Disease (COPD) and clinical outcomes in diagnosed patients: A scoping review","authors":"Carolina Ignacio Carlotto , Simone Bernardes , Priscilla Zanella , Flávia Moraes Silva","doi":"10.1016/j.rmed.2024.107773","DOIUrl":"10.1016/j.rmed.2024.107773","url":null,"abstract":"<div><h3>Background & aims</h3><p>Limited research exists on the association between dietary patterns (DP) and COPD risk or health-related outcomes. We reviewed existing literature to identify DP as a potential factor influencing COPD development and associated health outcomes in diagnosed individuals.</p></div><div><h3>Methods</h3><p>We followed the Joanna Briggs Institute methodology for this scoping review, conducting searches on PubMed, Scopus, Embase, and Web of Science to identify studies meeting our inclusion criteria (P, population - adults from the general population with or without COPD diagnosis; C, concept - DP; C, context - any setting). Two reviewers screened titles and abstracts, confirmed eligibility through full-text examination, extracted data using Redcap®, and assessed bias risk with the Newcastle Ottawa Scale.</p></div><div><h3>Results</h3><p>We analyzed 24 studies with sample sizes ranging from 121 to 421,426 individuals aged 20 to 75. Eighty-three percent investigated the role of DP in the COPD etiology, while 16.7 % examined health-related COPD outcomes. Food frequency questionnaires predominated (75 %) in exploring 23 distinct DP. Sixty-seven percent employed a priori-defined DP, focusing on the Mediterranean Diet (MedDiet) and Healthy Eating Index (HEI), while 33.3 % utilized a posteriori-defined DP, mainly represented by the Prudent and Traditional DP. Sixty percent of the studies reported significant associations between DP and COPD risk/odds. However, studies examining DP and COPD patient outcomes produced varied results.</p></div><div><h3>Conclusions</h3><p>Most studies focused on assessing COPD risk using a priori-defined DP, particularly emphasizing the Med Diet and HEI. Overall, the studies found that healthy DPs are associated with reduced risk of COPD and improved outcomes in diagnosed patients.</p></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subglottic Dilation in Preterm infants 早产儿声门下扩张术

IF 3.5 3区医学

Respiratory medicine Pub Date : 2024-08-13 DOI: 10.1016/j.rmed.2024.107770

Shabih Manzar

引用次数: 0

Prevalence and burden of loneliness in COPD: A systematic review and meta-analysis 慢性阻塞性肺病患者孤独感的发生率和负担：系统回顾和元分析》（Prevalence and Burden of Loneliness in COPD: A Systematic Review and Meta-analysis）。

IF 3.5 3区医学

Respiratory medicine Pub Date : 2024-08-12 DOI: 10.1016/j.rmed.2024.107768

Jaber S. Alqahtani , Abayomi Arowosegbe , Abdulelah M. Aldhahir , Saeed M. Alghamdi , Abdullah A. Alqarni , Rayan A. Siraj , Ibrahim A. AlDraiwiesh , Hassan Alwafi , Tope Oyelade

{"title":"Prevalence and burden of loneliness in COPD: A systematic review and meta-analysis","authors":"Jaber S. Alqahtani , Abayomi Arowosegbe , Abdulelah M. Aldhahir , Saeed M. Alghamdi , Abdullah A. Alqarni , Rayan A. Siraj , Ibrahim A. AlDraiwiesh , Hassan Alwafi , Tope Oyelade","doi":"10.1016/j.rmed.2024.107768","DOIUrl":"10.1016/j.rmed.2024.107768","url":null,"abstract":"<div><h3>Background</h3><p>Loneliness poses significant public health concerns on a global scale. Being alone and lacking social connections have been proven to impact prognosis and response to treatment in different diseases, including COPD. Yet, the prevalence and burden of loneliness on COPD outcomes remain unclear.</p></div><div><h3>Methods</h3><p>Various relevant databases were systematically searched in March 2024. The quality of the studies included was assessed using a modified Newcastle-Ottawa Scale. The random effect model was used to compute the pooled prevalence and associated 95 % confidence intervals (95%CI) of loneliness and living alone in COPD patients.</p></div><div><h3>Results</h3><p>After reviewing 256 studies, 11 studies, including 4644 COPD patients, met the inclusion criteria and were included in the systematic review. Of the included studies, 5/11 (45.5%) reported the prevalence of loneliness or lone living among COPD patients and were included in the meta-analysis. The prevalence of loneliness and lone living among COPD patients was 32% (95% CI = 16%–48%) and 29% (95% CI = 16%–41%), respectively. The Three-item UCLA loneliness scale was the most often used loneliness assessment tool (5/11, 45.5%). Loneliness and lone living were associated with poor outcomes, including emergency department visits, readmissions, depression, and reduced pulmonary rehabilitation response.</p></div><div><h3>Conclusion</h3><p>Despite one-third of COPD patients experiencing loneliness, researchers have not consistently documented its impact on COPD outcomes. More studies are needed to assess the impact of loneliness on COPD and how to mitigate the negative effects on patients’ outcomes.</p></div>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0