Respiratory medicine最新文献

{"title":"Hypersensitivity pneumonitis radiologic features in interstitial lung diseases.","authors":"Tamar Shalmon, Ophir Freund, Ori Wand, Sonia Schneer, Tzlil Hershko, Yitzhak Hadad, Galit Aviram, Amir Bar-Shai, Yochai Adir, David Shitrit, Avraham Unterman","doi":"10.1016/j.rmed.2024.107901","DOIUrl":"10.1016/j.rmed.2024.107901","url":null,"abstract":"<p><strong>Background: </strong>The radiologic criteria of hypersensitivity pneumonitis (HP) guidelines focus on four HP compatible features (HPCF) in high-resolution computed tomography (HRCT): ground glass opacities, mosaic attenuation, air-trapping, and centrilobular nodules. However, evidence to support these criteria are limited.</p><p><strong>Methods: </strong>Consecutive interstitial lung disease (ILD) patients who underwent HRCT between 2016 and 2021 in three medical centers were included. We assessed the prevalence of HPCF in each ILD and their association with HP diagnosis. We evaluated the impact of HPCF amount for HP diagnosis and the performance of the radiologic criteria by the ATS/JRS/ALAT and CHEST HP guidelines.</p><p><strong>Results: </strong>436 patients with ILD were included (mean age 66, 48 % females), of them, 56 (13 %) with HP. All four HPCF were more prevalent in HP than in non-HP ILD (p < 0.001 for all). In multivariate analysis, air-trapping was the strongest independent predictor (AOR 4.1, 95 % CI 2-8.4, p < 0.001). Centrilobular nodules were present almost exclusively in HP and smoking-related ILD. The amount of HPCF in HRCT had an excellent predictive ability for HP diagnosis (receiver operating characteristic AUC 0.85, 95 % CI 0.80-0.90). The radiologic criteria of both guidelines had high specificity for \"typical HP\" and high sensitivity for \"compatible with HP\", although with low positive predictive values. Our findings remained robust even when including only patients that had a diagnostic biopsy.</p><p><strong>Conclusion: </strong>The presence and amount of HPCF in HRCT predicted HP diagnosis in real-life settings. While current HP radiologic criteria demonstrated good diagnostic performance, our findings highlight areas for future improvement.</p>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"107901"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between serum indium levels and preserved ratio impaired spirometry among non-smoking industrial workers: A nationwide cross-sectional study in Taiwan.","authors":"I-Jen Chang, Chuan-Yen Sun, Wei-Chih Chen, Ting-An Yang, Hao-Yi Fan, Yang-Chieh Brian Chen, Yu-Chung Tsao","doi":"10.1016/j.rmed.2024.107908","DOIUrl":"10.1016/j.rmed.2024.107908","url":null,"abstract":"<p><strong>Background: </strong>Indium, a rare heavy metal, extensively used in flat panel display manufacturing, poses potential respiratory health risks to workers. Preserved ratio impaired spirometry (PRISm), a term describing nonobstructive lung function abnormalities, is associated with adverse health outcomes. Despite known risks, the relationship between serum indium levels and PRISm remains underexplored.</p><p><strong>Methods: </strong>A cross-sectional cohort study among non-smoking industry workers potentially exposed to indium in Taiwan was conducted in 2020. Demographic data, and pulmonary function tests were collected comprehensively. Serum indium levels were quantified using inductively coupled plasma mass spectrometry, and respiratory symptoms were obtained via questionnaire. PRISm was defined as FEV₁/FVC ≥0.7 with FEV1 < 80 % predicted. Univariate, and multivariate logistic regression analyses were conducted to identify risk factors associated with PRISm.</p><p><strong>Results: </strong>Among 2575 eligible participants, those with abnormal serum indium levels (≥3 ng/mL) were older, predominantly male, and had longer total working duration. PRISm prevalence was significantly higher in individuals with abnormal indium levels (22.7 % vs. 7.6 %). PRISm subjects exhibited a higher proportion of abnormal indium levels. Multivariate analysis revealed that serum indium levels ≥3 ng/mL and female sex were significant risk factors for PRISm after adjusting sex, age, body mass index and working duration.</p><p><strong>Conclusion: </strong>This study demonstrates a significant association between elevated serum indium levels and increased PRISm prevalence among non-smoking workers in Taiwan. Findings highlight the importance of assessing serum indium levels in occupational health surveillance and revising exposure standards to mitigate respiratory health risks associated with indium exposure.</p>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"107908"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral airways dysfunction measured by oscillometry differentiates asthma from inducible laryngeal obstruction.","authors":"Patrick Donohue, Margaret Connolly, Marcus D'Alfonso, Gerriann Jackson, Liane C Grasso, Xueya Cai, Ashley P O'Connell Ferster, G Todd Schneider, Sandhya Khurana, Steve N Georas","doi":"10.1016/j.rmed.2024.107905","DOIUrl":"10.1016/j.rmed.2024.107905","url":null,"abstract":"<p><strong>Background: </strong>Inducible laryngeal obstruction (ILO, also called vocal cord dysfunction) can be difficult to distinguish clinically from asthma. Limited studies have explored the use of respiratory oscillometry to detect changes unique to ILO, but more study is needed to determine if routine oscillometry can differentiate these two clinical entities.</p><p><strong>Objective: </strong>Determine if impedance variables measured on routine oscillometry over tidal breathing vary between individuals with asthma and ILO.</p><p><strong>Methods: </strong>Subjects with asthma and ILO were recruited to participate in a single-center, observational study at the University of Rochester Medical Center. Oscillometry measurements were obtained over tidal breathing according to technical standards. Exploratory oscillometry variables were analyzed, as well as standard oscillometry variables including measures of peripheral airways dysfunction.</p><p><strong>Results: </strong>25 subjects (12 with asthma and 13 with ILO) were recruited and included in the analysis. Measures of peripheral airways dysfunction including frequency dependence of resistance (R5-R20), area under the reactance curve (AX), and reactance at 5 Hz (X5) were significantly more abnormal in asthma subjects compared to ILO subjects (p = 0.039, p = 0.008, and p = 0.0327 respectively). Resistance at 5 Hz (R5) was not statistically different between asthma and ILO (p = 0.301). Exploratory variables, including inspiratory impedance and the standard deviation of impedance, were not significantly different between asthma and ILO.</p><p><strong>Conclusion: </strong>Measures of peripheral airways dysfunction by oscillometry were significantly different in subjects with asthma compared to ILO and more significant in subjects with poor asthma control. There were no exploratory oscillometry variables that were significantly different between ILO and asthma.</p>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"107905"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11700764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical impact of pre-determined guideline selection for the diagnosis of fibrotic hypersensitivity pneumonitis.","authors":"Pedro Magalhães Ferreira, Francisco Machado, David Barros Coelho, André Terras Alexandre, Hélder Novais Bastos, Patrícia Mota, Natália Melo, Susana Guimarães, Conceição Souto-Moura, André Carvalho, António Morais","doi":"10.1016/j.rmed.2024.107925","DOIUrl":"10.1016/j.rmed.2024.107925","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>International guidelines for the diagnosis of Hypersensitivity Pneumonitis (HP) have improved the diagnostic standardization of this heterogeneous interstitial lung disease. Our goal was to determine how the final multidisciplinary discussion confidence level for suspected fibrotic HP (fHP) can be impacted by the application of different guidelines validated in this context.</p><p><strong>Materials and methods: </strong>Retrospective study including patients submitted to transbronchial lung cryobiopsy (TBLC) with a final multidisciplinary meeting diagnosis of fHP. Both guidelines were applied to all patients in a stepwise fashion and directly compared according to the level of confidence in a fHP diagnosis.</p><p><strong>Results: </strong>A total of 170 patients were diagnosed with fHP after TBLC and subsequent multidisciplinary discussion. Overall, there was a statistically significant change in proportion towards higher confidence diagnostic levels using the CHEST guideline (p < 0.0001). Changes were significant at three different levels: ATS/JRS/ALAT's \"fHP not excluded\" subgroup significantly upscaled to CHEST's \"provisional low-confidence\" subgroup (76.2 % increase; p < 0.001) and the proportion of patients in ATS/JRS/ALAT's \"low confidence\" subgroup significantly upscaled to both CHEST's \"provisional high-confidence\" (67.4 % increase; p < 0.001) and \"definitive fHP\" (50 % increase; p < 0.001) subgroups. The alternative application of the CHEST guideline in multidisciplinary discussion would have resulted in 73 less TBLC (42.9 % decrease versus the ATS/JRS/ALAT-oriented decision).</p><p><strong>Conclusions: </strong>This study suggests a significant increase in definite fHP diagnosis when applying the CHEST versus the ATS/JRS/ALAT guideline, resulting in almost a 43 % decrease in referrals to TBLC when compared with the latter due to a combination of less strict radiological criteria and a more prominent role of BAL.</p>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"107925"},"PeriodicalIF":3.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum cholesterol levels predict the survival in patients with idiopathic pulmonary fibrosis: A long-term follow up study.","authors":"Ranxun Chen, Guanning Zhong, Tong Ji, Qinghua Xu, Huarui Liu, Qingqing Xu, Lulu Chen, Jinghong Dai","doi":"10.1016/j.rmed.2024.107937","DOIUrl":"10.1016/j.rmed.2024.107937","url":null,"abstract":"<p><strong>Background: </strong>The relationship between serum lipid with idiopathic pulmonary fibrosis (IPF) required to be explored. We aim to evaluate the association of serum lipid levels with mortality in patients with IPF.</p><p><strong>Materials and methods: </strong>This retrospective study included IPF patients with more than three years follow-up. We collected baseline demographics information, forced vital capacity (FVC)% predicted, carbon monoxide diffusion capacity (DLCO)% predicted, gender-age-physiology (GAP) index, and serum lipid levels, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C). We evaluate the relationship between the serum lipid levels and the disease severity, and the mortality in IPF.</p><p><strong>Results: </strong>This study enrolled 146 patients, with the three-year survival rate of 71.23 %. The median follow-up time was 46.5 months. There was no significant difference in baseline lipid levels between the survival and non-survival group. TG levels were positively correlated with DLCO% predicted (r = 0.189, p = 0.022) and negatively correlated with GAP index (r = -0.186, p = 0.025). After adjusting for GAP index, smoking history, body mass index and the use of antifibrotic and lipid-lowering drug, lower TC levels (HR: 0.74, 95 % CI: 0.58-0.94, p = 0.013) were identified as an independent risk factor for mortality.</p><p><strong>Conclusion: </strong>This study demonstrated that lower TC levels were associated with increased mortality in IPF. More investigations are required to explore the role of lipid metabolism in the pathogenesis of pulmonary fibrosis.</p>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"107937"},"PeriodicalIF":3.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stratifying risk in pulmonary arterial hypertension: Should we expect more?","authors":"Adriano R Tonelli, Sandeep Sahay","doi":"10.1016/j.rmed.2024.107926","DOIUrl":"10.1016/j.rmed.2024.107926","url":null,"abstract":"","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"107926"},"PeriodicalIF":3.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Rehabilitation and Functional Independence: Impact on Survival in Patients with Fibrotic Interstitial Lung Disease or Chronic Obstructive Pulmonary Disease.","authors":"Annina Elmiger, Thimo Marcin, Luc Bovet, Patrick Brun, Sabina A Guler","doi":"10.1016/j.rmed.2024.107933","DOIUrl":"https://doi.org/10.1016/j.rmed.2024.107933","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary rehabilitation (PR) aims to improve patients' functioning in interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD). The impact of change in functional independence during PR on subsequent survival has not been established. We aimed to determine functional independence during PR and its association with survival over three years post-PR.</p><p><strong>Methods: </strong>This retrospective cohort study included patients with fibrotic ILD or COPD who participated in a 3-week inpatient PR program. The Functional Independence Measure (FIM) was assessed at PR entry and discharge. Correlations between FIM and demographics, clinical/functional parameters were analyzed. Time from PR to death/lung transplantation/censoring was assessed, stratified by baseline/changes in FIM above/below the median. Multivariate Cox proportional hazard models were used to determine the impact of FIM on mortality risk.</p><p><strong>Results: </strong>223 patients (76 ILD/147 COPD) were included. Mean ± standard deviation (SD) age was 69±10 for ILD and 67±10 for COPD. FIM total and motor scores improved significantly in both groups. Baseline FIM showed a strong negative and change in 6-minute walk distance (6MWD) a strong positive correlation with change in FIM during PR. Each 1-point increase in FIM motor score was associated with a 3% lower risk of mortality (HR 0.97, 95%CI 0.94-1, p=0.03).</p><p><strong>Conclusions: </strong>Inpatient PR improves functional independence in patients with fibrotic ILD or COPD, and baseline and change in FIM are associated with survival up to three years post-PR. This emphasizes the importance of PR for all patients with chronic lung disease regardless of their initial level of independence.</p>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"107933"},"PeriodicalIF":3.5,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of IL13 genetic polymorphisms on COPD susceptibility in the Chinese Han population.","authors":"Zehua Yang, Yamei Zheng, Jie Zhao, Yi Zhong, Lei Zhang, Haihong Wu, Tian Xie, Yipeng Ding","doi":"10.1016/j.rmed.2024.107923","DOIUrl":"10.1016/j.rmed.2024.107923","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation. Interleukin-13 (IL13), associated with T-helper type 2 cells, plays a crucial role in COPD pathophysiology. This study aimed to investigate the relationship of single nucleotide polymorphisms (SNPs) in IL13 to COPD risk.</p><p><strong>Methods: </strong>Five candidate SNPs of IL13 were genotyped using MassARRAY iPLEX platform in a cohort of472 COPD patients and 472 healthy controls. Logistic regression analysis was used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs). Additionally, Multifactor dimensionality reduction (MDR) software was utilized to assess the combined impact of SNP-SNP interactions on COPD risk.</p><p><strong>Results: </strong>IL13 rs20541 (OR: 1.24, p: 0.028), rs1295685 (OR: 1.31, p: 0.006), rs848 (OR: 1.27, p: 0.016), and rs847 (OR: 1.30, p: 0.007) were associated with COPD risk. Moreover, IL13 variants were related to the increased COPD risk in females, individuals aged ≥68 year, non-smokers or non-drinkers. The optimal multi-locus model was identified as the combination of rs20541 and rs1295685.</p><p><strong>Conclusion: </strong>Our findings indicated the association between IL13 variants and an elevated risk of developing COPD, especially rs1295685 and rs847. These findings could have implications for understanding the role of IL13 variants in COPD predisposition.</p>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"107923"},"PeriodicalIF":3.5,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of interstitial lung abnormalities with cytotoxic agent-induced pneumonitis in patients with malignancy.","authors":"Kyohei Oishi, Hironao Hozumi, Nobuko Yoshizawa, Shintaro Ichikawa, Yusuke Inoue, Hideki Yasui, Yuzo Suzuki, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Satoshi Goshima, Naoki Inui, Takafumi Suda","doi":"10.1016/j.rmed.2024.107924","DOIUrl":"10.1016/j.rmed.2024.107924","url":null,"abstract":"<p><strong>Background and objective: </strong>The association between interstitial lung abnormalities (ILA) and various conditions and diseases, including drug-related pneumonitis (DRP), has been reported. However, the association of the presence of ILA with developing DRP in patients undergoing cytotoxic agent-based chemotherapy, one of the standard treatments for malignancies, remains unclear. This warrants urgent investigation.</p><p><strong>Methods: </strong>We included consecutive patients diagnosed with malignancy and treated with cytotoxic agents with/without immune checkpoint inhibitors (ICIs). We used Gray's method and multivariate Fine-Gray sub-distribution hazards analysis to evaluate the cumulative incidence of DRP (common terminology criteria for adverse events grade of ≥3) and the association between ILA and DRP development, respectively.</p><p><strong>Results: </strong>Among 786 patients, 58 (7.3 %) demonstrated ILA. Patients with ILA were older, predominantly male, and reported a higher smoking history compared to those without ILA. The 90-day cumulative incidence of cytotoxic agent-induced DRP with/without ICIs was significantly higher in patients with ILA than in those without ILA (6.0 % vs. 1.2 %, p = 0.006). Multivariate analysis, adjusted for age, sex, and smoking history, revealed that ILA was associated with an increased risk of developing DRP due to cytotoxic agents with/without ICIs (hazard ratio [HR] 3.11, 95 % confidence interval [CI]: 1.06-9.14, p = 0.039) and cytotoxic agents alone (HR: 5.53, 95 % CI: 1.55-19.7, p = 0.008).</p><p><strong>Conclusions: </strong>The presence of ILA is associated with an increased risk of developing DRP in patients undergoing cytotoxic agent-based chemotherapy. Therefore, evaluating the presence of ILA before determining chemotherapy regimens that include cytotoxic agents is recommended.</p>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"107924"},"PeriodicalIF":3.5,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of clinical characteristics in 1940 patients with acute pulmonary embolism.","authors":"Bo Chen, Wei Wang, Wenqian Zang, Jinjin Hu, Hengyun Li, Cong Wang, Yingwei Zhu, Yimin Mao, Pengfei Gao","doi":"10.1016/j.rmed.2024.107920","DOIUrl":"10.1016/j.rmed.2024.107920","url":null,"abstract":"<p><strong>Background: </strong>The clinical characteristics of acute pulmonary embolism (APE) according to mortality risk has been partly explored. Further research is required in light of the latest guide update on risk stratification for APE.</p><p><strong>Methods: </strong>We collected the data from hospitalized patients with APE. Patients were classified according to the 2019 European Society of Cardiology's (ESC) guidelines. The clinical traits between different risk stratification of APE was investigated.</p><p><strong>Results: </strong>A total of 1940 patients had APE. Patients who were stratified as high risk showed the highest frequency of both syncope (4.5 % vs 6.6 % vs 12.7 %; P = 0.002) and dyspnea (61.9 % vs 73.0 % vs 73.8 %, P = 0.007) when compared to the other two groups. The rates of deep venous thrombosis (DVT) were: 49.4 % in low-risk stratification, 63.2 % in intermediate-risk stratification, and 68.1 % in high-risk stratification, (P_{for trend} = 0.001), while the proportion of low-risk stratification patients increased (2.5 %-13.3 %, P_{for trend}<0.001).</p><p><strong>Conclusion: </strong>In conclusion, clinical characteristics differ among pulmonary embolism patients with different risk stratification. Furthermore, the percentage of low-risk patients increased progressively while overall in-hospital death rates among APE patients gradually decreased.</p>","PeriodicalId":21057,"journal":{"name":"Respiratory medicine","volume":" ","pages":"107920"},"PeriodicalIF":3.5,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}