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Electrospun aligned tacrolimus-loaded polycaprolactone biomaterials for peripheral nerve repair. 电纺定向他克莫司负载聚己内酯生物材料用于外周神经修复。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-04-01 Epub Date: 2023-10-11 DOI: 10.2217/rme-2023-0151
Holly N Gregory, Owein Guillemot-Legris, Daisy Crouch, Gareth Williams, James B Phillips
{"title":"Electrospun aligned tacrolimus-loaded polycaprolactone biomaterials for peripheral nerve repair.","authors":"Holly N Gregory, Owein Guillemot-Legris, Daisy Crouch, Gareth Williams, James B Phillips","doi":"10.2217/rme-2023-0151","DOIUrl":"10.2217/rme-2023-0151","url":null,"abstract":"<p><p><b>Background:</b> Efficacious repair of peripheral nerve injury is an unmet clinical need. The implantation of biomaterials containing neurotrophic drugs at the injury site could promote nerve regeneration and improve outcomes for patients. <b>Materials & methods:</b> Random and aligned electrospun poly-ε-caprolactone scaffolds containing encapsulated tacrolimus were fabricated, and the gene expression profile of Schwann cells (SCs) cultured on the surface was elucidated. On aligned fibers, the morphology of SCs and primary rat neurons was investigated. <b>Results:</b> Both scaffold types exhibited sustained release of drug, and the gene expression of SCs was modulated by both nanofibrous topography and the presence of tacrolimus. Aligned fibers promoted the alignment of SCs and orientated outgrowth from neurons. <b>Conclusion:</b> Electrospun PCL scaffolds with tacrolimus hold promise for the repair of peripheral nerve injury.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41210988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Animal models in peripheral nerve transection studies: a systematic review on study design and outcomes assessment. 外周神经横断研究中的动物模型：研究设计和结果评估的系统综述。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-04-01 Epub Date: 2023-10-19 DOI: 10.2217/rme-2023-0102
Bruna Lopes, André Coelho, Rui Alvites, Ana Catarina Sousa, Patrícia Sousa, Alícia Moreira, Luís Atayde, António Salgado, Stefano Geuna, Ana Colette Maurício
{"title":"Animal models in peripheral nerve transection studies: a systematic review on study design and outcomes assessment.","authors":"Bruna Lopes, André Coelho, Rui Alvites, Ana Catarina Sousa, Patrícia Sousa, Alícia Moreira, Luís Atayde, António Salgado, Stefano Geuna, Ana Colette Maurício","doi":"10.2217/rme-2023-0102","DOIUrl":"10.2217/rme-2023-0102","url":null,"abstract":"<p><p><b>Aim:</b> Peripheral nerve injury regeneration studies using animal models are crucial to different pre-clinical therapeutic approaches efficacy evaluation whatever the surgical technique explored. <b>Materials & methods:</b> A 944 articles systematic review on 'peripheral nerve injury in animal models' over the last 9 years was carried out. <b>Results:</b> It was found that 91% used rodents, and only 9% employed large animals. Different nerves are studied, with generated gaps (10,78 mm) and methods applied for regeneration evaluation uniformed. Sciatic nerve was the most used (88%), followed by median and facial nerves (2.6%), significantly different. <b>Conclusion:</b> There has not been a significant scale-up of the <i>in vivo</i> testing to large animal models (anatomically/physiologically closer to humans), allowing an improvement in translational medicine for clinical cases.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49681701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in January 2024. 2024 年 1 月干细胞研究和再生医学领域的行业动态。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2024-03-13 DOI: 10.2217/rme-2024-0034
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in January 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.2217/rme-2024-0034","DOIUrl":"https://doi.org/10.2217/rme-2024-0034","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in January 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140111289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The challenges and prospects of smooth muscle tissue engineering. 平滑肌组织工程的挑战与前景。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI: 10.2217/rme-2023-0230
Christofer S Baldwin, Shilpa Iyer, Raj R Rao
{"title":"The challenges and prospects of smooth muscle tissue engineering.","authors":"Christofer S Baldwin, Shilpa Iyer, Raj R Rao","doi":"10.2217/rme-2023-0230","DOIUrl":"10.2217/rme-2023-0230","url":null,"abstract":"<p><p>Many vascular disorders arise as a result of dysfunctional smooth muscle cells. Tissue engineering strategies have evolved as key approaches to generate functional vascular smooth muscle cells for use in cell-based precision and personalized regenerative medicine approaches. This article highlights some of the challenges that exist in the field and presents some of the prospects for translating research advancements into therapeutic modalities. The article emphasizes the need for better developing synergetic intracellular and extracellular cues in the processes to generate functional vascular smooth muscle cells from different stem cell sources for use in tissue engineering strategies.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10941056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in November 2023. 2023 年 11 月干细胞研究和再生医学领域的行业动态。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2024-03-01 Epub Date: 2024-02-08 DOI: 10.2217/rme-2024-0017
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in November 2023.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.2217/rme-2024-0017","DOIUrl":"10.2217/rme-2024-0017","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in November 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Slaughterhouse waste: a unique and sustainable source for dECM-based bioinks. 屠宰场废物：基于 dECM 的生物墨水的独特和可持续来源。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-03-01 Epub Date: 2024-02-15 DOI: 10.2217/rme-2023-0194
Meklit G Shibru, Zehara M Ali, Aliyaa S Almansoori, Jovana Paunovic, Igor V Pantic, Peter R Corridon
{"title":"Slaughterhouse waste: a unique and sustainable source for dECM-based bioinks.","authors":"Meklit G Shibru, Zehara M Ali, Aliyaa S Almansoori, Jovana Paunovic, Igor V Pantic, Peter R Corridon","doi":"10.2217/rme-2023-0194","DOIUrl":"10.2217/rme-2023-0194","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bibliometric analysis of organoids in regenerative medicine-related research worldwide over two decades (2002-2022). 二十年来（2002-2022 年）全球再生医学相关研究中有机体的文献计量分析。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-03-01 Epub Date: 2024-03-07 DOI: 10.2217/rme-2023-0176
Jajar Setiawan, Dicky Moch Rizal, Fajar Sofyantoro, Dwi Sendi Priyono, Nur Indah Septriani, Wulan Usfi Mafiroh, Takenori Kotani, Takashi Matozaki, Wahyu Aristyaning Putri
{"title":"Bibliometric analysis of organoids in regenerative medicine-related research worldwide over two decades (2002-2022).","authors":"Jajar Setiawan, Dicky Moch Rizal, Fajar Sofyantoro, Dwi Sendi Priyono, Nur Indah Septriani, Wulan Usfi Mafiroh, Takenori Kotani, Takashi Matozaki, Wahyu Aristyaning Putri","doi":"10.2217/rme-2023-0176","DOIUrl":"10.2217/rme-2023-0176","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to evaluate the trends in organoid culture research within the field of regenerative medicine from 2002 to 2022. <b>Methods:</b> The worldwide distribution of organoid research in regenerative medicine articles indexed in the Scopus database was analyzed. <b>Result:</b> A total of 840 documents were analyzed, averaging 42 publications annually. The USA (n = 296) led in publications, followed by China (n = 127), Japan (n = 91) and the UK (n = 75). Since 2011, research has surged, particularly in China, which emerged as a prominent center. <b>Conclusion:</b> The findings highlight significant growth in organoid research, promising future organ transplantation. Research trends integrate tissue engineering, gene modification and induced pluripotent stem cell technologies, reflecting a move toward personalized medicine.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in October 2023. 2023 年 10 月干细胞研究和再生医学领域的行业动态。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2024-02-01 Epub Date: 2024-02-09 DOI: 10.2217/rme-2024-0002
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in October 2023.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.2217/rme-2024-0002","DOIUrl":"10.2217/rme-2024-0002","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in October 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139707616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modification of the inflammatory profile of mesenchymal stem cells using different culture conditions. 利用不同的培养条件改变间充质干细胞的炎症特征。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-02-01 Epub Date: 2024-02-15 DOI: 10.2217/rme-2023-0162
Alison A Smith, Charles F Bellows
{"title":"Modification of the inflammatory profile of mesenchymal stem cells using different culture conditions.","authors":"Alison A Smith, Charles F Bellows","doi":"10.2217/rme-2023-0162","DOIUrl":"10.2217/rme-2023-0162","url":null,"abstract":"<p><p><b>Aim:</b> Mesenchymal stem cells (MSCs) are pluripotent cells with significant therapeutic potential. The objective of this study was to examine the inflammatory profile of MSCs cultured under different conditions. <b>Methods:</b> MSCs were cultured by three strategies: seeding on an extracellular matrix (ECM), spheroids in static culture and spheroids in a bioreactor. Paracrine factors and CD206, a marker of M2 macrophage phenotype, were measured. <b>Results:</b> MSCs grown as spheroids in a bioreactor produced more IL-6 and IL-8 (p < 0.05). Supernatant collected from spheroids under both culture conditions increased the M2 macrophage phenotype almost twofold. <b>Conclusion:</b> Results indicate that the inflammatory profile of the supernatant collected from MSCs can be modified through culture conditions which has impacts for the future of regenerative medicine.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ink-spiring innovations: 3D bioprinting skin models for disease discovery. 墨水激发的创新：用于疾病发现的三维生物打印皮肤模型。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-02-01 Epub Date: 2024-01-05 DOI: 10.2217/rme-2023-0216
Rafaela Mayumi Simoes Torigoe, Alexander Revzin, Andrew Badley, Saranya Wyles
{"title":"Ink-spiring innovations: 3D bioprinting skin models for disease discovery.","authors":"Rafaela Mayumi Simoes Torigoe, Alexander Revzin, Andrew Badley, Saranya Wyles","doi":"10.2217/rme-2023-0216","DOIUrl":"10.2217/rme-2023-0216","url":null,"abstract":"<p><p>Tweetable abstract Inflammatory skin diseases account for most chronic skin conditions. 3D bioprinting is an exciting technology that can revolutionize the understanding and approach to treatment of atopic dermatitis and graft-versus-host disease.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139098548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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