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Peripheral nerve regeneration: a challenge far from being overcome. 外周神经再生：一个远未克服的挑战。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-04-01 Epub Date: 2023-10-03 DOI: 10.2217/rme-2023-0072
Rui Alvites, Bruna Lopes, André Coelho, Ana Colette Maurício
{"title":"Peripheral nerve regeneration: a challenge far from being overcome.","authors":"Rui Alvites, Bruna Lopes, André Coelho, Ana Colette Maurício","doi":"10.2217/rme-2023-0072","DOIUrl":"10.2217/rme-2023-0072","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"155-159"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in December 2023. 2023 年 12 月干细胞研究和再生医学领域的行业动态。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2024-04-01 Epub Date: 2024-02-15 DOI: 10.2217/rme-2024-0029
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in December 2023.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.2217/rme-2024-0029","DOIUrl":"10.2217/rme-2024-0029","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in December 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"145-153"},"PeriodicalIF":2.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An assessment of co-contraction in reinnervated muscle. 再神经支配肌肉共收缩的评估。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-04-01 Epub Date: 2023-11-13 DOI: 10.2217/rme-2023-0049
Matthew Wilcox, Hazel Brown, Kathryn Johnson, Marco Sinisi, Tom J Quick
{"title":"An assessment of co-contraction in reinnervated muscle.","authors":"Matthew Wilcox, Hazel Brown, Kathryn Johnson, Marco Sinisi, Tom J Quick","doi":"10.2217/rme-2023-0049","DOIUrl":"10.2217/rme-2023-0049","url":null,"abstract":"<p><p><b>Aim:</b> To investigate co-contraction in reinnervated elbow flexor muscles following a nerve transfer. <b>Materials & methods:</b> 12 brachial plexus injury patients who received a nerve transfer to reanimate elbow flexion were included in this study. Surface electromyography (EMG) recordings were used to quantify co-contraction during sustained and repeated isometric contractions of reinnervated and contralateral uninjured elbow flexor muscles. <b>Reuslts:</b> For the first time, this study reveals reinnervated muscles demonstrated a trend toward higher co-contraction ratios when compared with uninjured muscle and this is correlated with an earlier onset of muscle fatigability. <b>Conclusion:</b> Measurements of co-contraction should be considered within muscular function assessments to help drive improvements in motor recovery therapies.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"161-170"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89719377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction: Photoencapsulated-BMP2 in visible light-cured thiol-acrylate hydrogels for craniofacial bone tissue engineering. 撤回：可见光固化硫醇-丙烯酸酯水凝胶中的光胶囊化 BMP2 用于颅面部骨组织工程。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-04-01 Epub Date: 2024-03-05 DOI: 10.2217/rme-2020-0062r1
{"title":"Retraction: Photoencapsulated-BMP2 in visible light-cured thiol-acrylate hydrogels for craniofacial bone tissue engineering.","authors":"","doi":"10.2217/rme-2020-0062r1","DOIUrl":"10.2217/rme-2020-0062r1","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"207"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction: Photoencapsulated-mesenchymal stromal cells in biodegradable thiol-acrylate hydrogels enhance regeneration of craniofacial bone tissue defects. 撤回：生物可降解硫醇-丙烯酸酯水凝胶中的光胶囊化间充质基质细胞可促进颅面部骨组织缺损的再生。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-04-01 Epub Date: 2024-03-05 DOI: 10.2217/rme-2020-0061r1
{"title":"Retraction: Photoencapsulated-mesenchymal stromal cells in biodegradable thiol-acrylate hydrogels enhance regeneration of craniofacial bone tissue defects.","authors":"","doi":"10.2217/rme-2020-0061r1","DOIUrl":"10.2217/rme-2020-0061r1","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"205"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrospun aligned tacrolimus-loaded polycaprolactone biomaterials for peripheral nerve repair. 电纺定向他克莫司负载聚己内酯生物材料用于外周神经修复。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-04-01 Epub Date: 2023-10-11 DOI: 10.2217/rme-2023-0151
Holly N Gregory, Owein Guillemot-Legris, Daisy Crouch, Gareth Williams, James B Phillips
{"title":"Electrospun aligned tacrolimus-loaded polycaprolactone biomaterials for peripheral nerve repair.","authors":"Holly N Gregory, Owein Guillemot-Legris, Daisy Crouch, Gareth Williams, James B Phillips","doi":"10.2217/rme-2023-0151","DOIUrl":"10.2217/rme-2023-0151","url":null,"abstract":"<p><p><b>Background:</b> Efficacious repair of peripheral nerve injury is an unmet clinical need. The implantation of biomaterials containing neurotrophic drugs at the injury site could promote nerve regeneration and improve outcomes for patients. <b>Materials & methods:</b> Random and aligned electrospun poly-ε-caprolactone scaffolds containing encapsulated tacrolimus were fabricated, and the gene expression profile of Schwann cells (SCs) cultured on the surface was elucidated. On aligned fibers, the morphology of SCs and primary rat neurons was investigated. <b>Results:</b> Both scaffold types exhibited sustained release of drug, and the gene expression of SCs was modulated by both nanofibrous topography and the presence of tacrolimus. Aligned fibers promoted the alignment of SCs and orientated outgrowth from neurons. <b>Conclusion:</b> Electrospun PCL scaffolds with tacrolimus hold promise for the repair of peripheral nerve injury.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"171-187"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41210988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Animal models in peripheral nerve transection studies: a systematic review on study design and outcomes assessment. 外周神经横断研究中的动物模型：研究设计和结果评估的系统综述。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-04-01 Epub Date: 2023-10-19 DOI: 10.2217/rme-2023-0102
Bruna Lopes, André Coelho, Rui Alvites, Ana Catarina Sousa, Patrícia Sousa, Alícia Moreira, Luís Atayde, António Salgado, Stefano Geuna, Ana Colette Maurício
{"title":"Animal models in peripheral nerve transection studies: a systematic review on study design and outcomes assessment.","authors":"Bruna Lopes, André Coelho, Rui Alvites, Ana Catarina Sousa, Patrícia Sousa, Alícia Moreira, Luís Atayde, António Salgado, Stefano Geuna, Ana Colette Maurício","doi":"10.2217/rme-2023-0102","DOIUrl":"10.2217/rme-2023-0102","url":null,"abstract":"<p><p><b>Aim:</b> Peripheral nerve injury regeneration studies using animal models are crucial to different pre-clinical therapeutic approaches efficacy evaluation whatever the surgical technique explored. <b>Materials & methods:</b> A 944 articles systematic review on 'peripheral nerve injury in animal models' over the last 9 years was carried out. <b>Results:</b> It was found that 91% used rodents, and only 9% employed large animals. Different nerves are studied, with generated gaps (10,78 mm) and methods applied for regeneration evaluation uniformed. Sciatic nerve was the most used (88%), followed by median and facial nerves (2.6%), significantly different. <b>Conclusion:</b> There has not been a significant scale-up of the <i>in vivo</i> testing to large animal models (anatomically/physiologically closer to humans), allowing an improvement in translational medicine for clinical cases.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"189-203"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49681701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in January 2024. 2024 年 1 月干细胞研究和再生医学领域的行业动态。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2024-03-13 DOI: 10.2217/rme-2024-0034
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in January 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.2217/rme-2024-0034","DOIUrl":"https://doi.org/10.2217/rme-2024-0034","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in January 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140111289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The challenges and prospects of smooth muscle tissue engineering. 平滑肌组织工程的挑战与前景。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI: 10.2217/rme-2023-0230
Christofer S Baldwin, Shilpa Iyer, Raj R Rao
{"title":"The challenges and prospects of smooth muscle tissue engineering.","authors":"Christofer S Baldwin, Shilpa Iyer, Raj R Rao","doi":"10.2217/rme-2023-0230","DOIUrl":"10.2217/rme-2023-0230","url":null,"abstract":"<p><p>Many vascular disorders arise as a result of dysfunctional smooth muscle cells. Tissue engineering strategies have evolved as key approaches to generate functional vascular smooth muscle cells for use in cell-based precision and personalized regenerative medicine approaches. This article highlights some of the challenges that exist in the field and presents some of the prospects for translating research advancements into therapeutic modalities. The article emphasizes the need for better developing synergetic intracellular and extracellular cues in the processes to generate functional vascular smooth muscle cells from different stem cell sources for use in tissue engineering strategies.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"135-143"},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10941056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in November 2023. 2023 年 11 月干细胞研究和再生医学领域的行业动态。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2024-03-01 Epub Date: 2024-02-08 DOI: 10.2217/rme-2024-0017
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in November 2023.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.2217/rme-2024-0017","DOIUrl":"10.2217/rme-2024-0017","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in November 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"105-112"},"PeriodicalIF":2.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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