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Facilitating the ethical sourcing of donor hematopoietic stem cells for cell and gene therapy research and development. 为细胞和基因疗法的研究与开发提供符合道德标准的造血干细胞捐献来源。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-06-02 Epub Date: 2024-06-18 DOI: 10.1080/17460751.2024.2357930
Lina Hamad, Choon Key Chekar, Chloe Anthias, Laura Machin
{"title":"Facilitating the ethical sourcing of donor hematopoietic stem cells for cell and gene therapy research and development.","authors":"Lina Hamad, Choon Key Chekar, Chloe Anthias, Laura Machin","doi":"10.1080/17460751.2024.2357930","DOIUrl":"10.1080/17460751.2024.2357930","url":null,"abstract":"<p><p><b>Aim:</b> Unrelated stem cell donor registries (DRs) are increasingly engaging in the field of cell and gene therapy (CGT). This study aims to explore the values, concerns, needs and expectations of donors and members of the public on donating hematopoietic stem cells (HSCs) for CGT.<b>Methods:</b> Seven focus groups were conducted in 2019 with members of the public, prospective donors and donors on the Anthony Nolan DR in the UK.<b>Results:</b> Participants expressed concerns over increased frequency of donation and incidental findings and required more information on the type of research including the purpose and possible outcomes.<b>Conclusion:</b> Addressing donors' concerns, needs and expectations on donating cellular materials for CGT research and development is essential to maintaining the highest standards for donor care and safety within this rapidly emerging field.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"317-326"},"PeriodicalIF":2.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PXL01 alters macrophage response with no effect on axonal outgrowth or Schwann cell response after nerve repair in rats. PXL01 可改变巨噬细胞的反应，但对大鼠神经修复后的轴突生长或许旺细胞反应没有影响。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-06-02 Epub Date: 2024-07-03 DOI: 10.1080/17460751.2024.2361515
Derya Burcu Hazer Rosberg, Lena Stenberg, Margit Mahlapuu, Lars B Dahlin
{"title":"PXL01 alters macrophage response with no effect on axonal outgrowth or Schwann cell response after nerve repair in rats.","authors":"Derya Burcu Hazer Rosberg, Lena Stenberg, Margit Mahlapuu, Lars B Dahlin","doi":"10.1080/17460751.2024.2361515","DOIUrl":"10.1080/17460751.2024.2361515","url":null,"abstract":"<p><p><b>Background:</b> Adjunctive pharmacological treatment may improve nerve regeneration. We investigated nerve regeneration processes of PXL01 - a lactoferrin-derived peptide - after repair of the sciatic nerve in healthy Wistar rats.<b>Materials & methods:</b> PXL01, sodium hyaluronate (carrier) or sodium chloride was administered around the repair. After 6 days axonal outgrowth, Schwann cell response, pan- (CD68) and pro-healing (CD206) macrophages in sciatic nerve, sensory neuronal response in dorsal root ganglia (DRG) and expression of heat shock protein 27 (HSP27) in sciatic nerves and DRGs were analyzed.<b>Results:</b> Despite a lower number of pan-macrophages, other investigated variables in sciatic nerves or DRGs did not differ between the treatment groups.<b>Conclusion:</b> PLX01 applied locally inhibits inflammation through pan-macrophages in repaired sciatic nerves without any impact on nerve regeneration or pro-healing macrophages.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"327-343"},"PeriodicalIF":2.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in February 2024. 2024 年 2 月干细胞研究和再生医学领域的行业动态。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-06-02 Epub Date: 2024-04-30 DOI: 10.1080/17460751.2024.2340888
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in February 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2024.2340888","DOIUrl":"https://doi.org/10.1080/17460751.2024.2340888","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in February 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"19 6","pages":"279-287"},"PeriodicalIF":2.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of allograft bone matrix in clinical orthopedics. 异体骨基质在临床骨科中的应用。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-05-03 Epub Date: 2024-07-19 DOI: 10.1080/17460751.2024.2353473
Shaan Manawar, Erica Myrick, Peter Awad, Victor Hung, Cassidy Hinton, Keith Kenter, Karen Bovid, Yong Li
{"title":"Use of allograft bone matrix in clinical orthopedics.","authors":"Shaan Manawar, Erica Myrick, Peter Awad, Victor Hung, Cassidy Hinton, Keith Kenter, Karen Bovid, Yong Li","doi":"10.1080/17460751.2024.2353473","DOIUrl":"10.1080/17460751.2024.2353473","url":null,"abstract":"<p><p>Clinical orthopedics continuously aims to improve methods for bone formation. Clinical applications where bone formation is necessary include critical long bone defects in orthopedic trauma or tumor patients. Though some biomaterials combined with autologous stem cells significantly improve bone repair, critical-size damages are still challenged with the suitable implantation of biomaterials and donor cell survival. Extracellular matrix (ECM) is the fundamental structure in tissues that can nest and nourish resident cells as well as support specific functions of the tissue type. ECM also plays a role in cell signaling to promote bone growth, healing and turnover. In the last decade, the use of bone-derived ECMs or ECM-similar biomaterials have been widely investigated, including decellularized and demineralized bone ECM. In this article, we reviewed the current productions and applications of decellularized and demineralized bone matrices. We also introduce the current study of whole limb decellularization and recellularization.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"247-256"},"PeriodicalIF":2.4,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in January 2024. 2024 年 1 月干细胞研究和再生医学领域的行业动态。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-05-03 Epub Date: 2024-03-13 DOI: 10.2217/rme-2024-0034
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in January 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.2217/rme-2024-0034","DOIUrl":"https://doi.org/10.2217/rme-2024-0034","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in January 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"19 5","pages":"209-219"},"PeriodicalIF":2.4,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral nerve regeneration: a challenge far from being overcome. 外周神经再生：一个远未克服的挑战。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-04-01 Epub Date: 2023-10-03 DOI: 10.2217/rme-2023-0072
Rui Alvites, Bruna Lopes, André Coelho, Ana Colette Maurício
{"title":"Peripheral nerve regeneration: a challenge far from being overcome.","authors":"Rui Alvites, Bruna Lopes, André Coelho, Ana Colette Maurício","doi":"10.2217/rme-2023-0072","DOIUrl":"10.2217/rme-2023-0072","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"155-159"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in December 2023. 2023 年 12 月干细胞研究和再生医学领域的行业动态。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2024-04-01 Epub Date: 2024-02-15 DOI: 10.2217/rme-2024-0029
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in December 2023.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.2217/rme-2024-0029","DOIUrl":"10.2217/rme-2024-0029","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in December 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"145-153"},"PeriodicalIF":2.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An assessment of co-contraction in reinnervated muscle. 再神经支配肌肉共收缩的评估。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-04-01 Epub Date: 2023-11-13 DOI: 10.2217/rme-2023-0049
Matthew Wilcox, Hazel Brown, Kathryn Johnson, Marco Sinisi, Tom J Quick
{"title":"An assessment of co-contraction in reinnervated muscle.","authors":"Matthew Wilcox, Hazel Brown, Kathryn Johnson, Marco Sinisi, Tom J Quick","doi":"10.2217/rme-2023-0049","DOIUrl":"10.2217/rme-2023-0049","url":null,"abstract":"<p><p><b>Aim:</b> To investigate co-contraction in reinnervated elbow flexor muscles following a nerve transfer. <b>Materials & methods:</b> 12 brachial plexus injury patients who received a nerve transfer to reanimate elbow flexion were included in this study. Surface electromyography (EMG) recordings were used to quantify co-contraction during sustained and repeated isometric contractions of reinnervated and contralateral uninjured elbow flexor muscles. <b>Reuslts:</b> For the first time, this study reveals reinnervated muscles demonstrated a trend toward higher co-contraction ratios when compared with uninjured muscle and this is correlated with an earlier onset of muscle fatigability. <b>Conclusion:</b> Measurements of co-contraction should be considered within muscular function assessments to help drive improvements in motor recovery therapies.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"161-170"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89719377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction: Photoencapsulated-BMP2 in visible light-cured thiol-acrylate hydrogels for craniofacial bone tissue engineering. 撤回：可见光固化硫醇-丙烯酸酯水凝胶中的光胶囊化 BMP2 用于颅面部骨组织工程。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-04-01 Epub Date: 2024-03-05 DOI: 10.2217/rme-2020-0062r1
{"title":"Retraction: Photoencapsulated-BMP2 in visible light-cured thiol-acrylate hydrogels for craniofacial bone tissue engineering.","authors":"","doi":"10.2217/rme-2020-0062r1","DOIUrl":"10.2217/rme-2020-0062r1","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"207"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction: Photoencapsulated-mesenchymal stromal cells in biodegradable thiol-acrylate hydrogels enhance regeneration of craniofacial bone tissue defects. 撤回：生物可降解硫醇-丙烯酸酯水凝胶中的光胶囊化间充质基质细胞可促进颅面部骨组织缺损的再生。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-04-01 Epub Date: 2024-03-05 DOI: 10.2217/rme-2020-0061r1
{"title":"Retraction: Photoencapsulated-mesenchymal stromal cells in biodegradable thiol-acrylate hydrogels enhance regeneration of craniofacial bone tissue defects.","authors":"","doi":"10.2217/rme-2020-0061r1","DOIUrl":"10.2217/rme-2020-0061r1","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"205"},"PeriodicalIF":2.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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