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Early delivery of human umbilical cord mesenchymal stem cells improves healing in a rat model of Achilles tendinopathy. 早期输送人脐带间充质干细胞可改善跟腱病大鼠模型的愈合。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-02-01 Epub Date: 2024-02-28 DOI: 10.2217/rme-2023-0222
Ze Yuan, Ding Yu, Yanxue Wang, Lijiaqi Liu, Junchao Wang, Chao Ma, Shaoling Wu
{"title":"Early delivery of human umbilical cord mesenchymal stem cells improves healing in a rat model of Achilles tendinopathy.","authors":"Ze Yuan, Ding Yu, Yanxue Wang, Lijiaqi Liu, Junchao Wang, Chao Ma, Shaoling Wu","doi":"10.2217/rme-2023-0222","DOIUrl":"10.2217/rme-2023-0222","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to explore the efficacy and optimal delivery time of human umbilical cord mesenchymal stem cells (hUC-MSCs) in treating collagenase-induced Achilles tendinopathy. <b>Methods:</b> Achilles tendinopathy in rats at early or advanced stages was induced by injecting collagenase I into bilateral Achilles tendons. A total of 28 injured rats were injected with a hUC-MSC solution or normal saline into bilateral tendons twice and sampled after 4 weeks for histological staining, gene expression analysis, transmission electron microscope assay and biomechanical testing analysis. <b>Results:</b> The results revealed better histological performance and a larger collagen fiber diameter in the MSC group. mRNA expression of TNF-α, IL-1β and MMP-3 was lower after MSC transplantation. Early MSC delivery promoted collagen I and TIMP-3 synthesis, and strengthened tendon toughness. <b>Conclusion:</b> hUC-MSCs demonstrated a therapeutic effect in treating collagenase-induced Achilles tendinopathy, particularly in the early stage of tendinopathy.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139983699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Glossary for Advanced Therapies. 高级疗法词汇》。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2024-01-16 DOI: 10.2217/rme-2023-1812s
{"title":"The Glossary for Advanced Therapies.","authors":"","doi":"10.2217/rme-2023-1812s","DOIUrl":"https://doi.org/10.2217/rme-2023-1812s","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in March 2024. 2024 年 3 月干细胞研究和再生医学领域的行业动态。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-01-01 Epub Date: 2024-05-28 DOI: 10.1080/17460751.2024.2353496
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in March 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2024.2353496","DOIUrl":"10.1080/17460751.2024.2353496","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in March 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in April 2024. 2024 年 4 月干细胞研究和再生医学领域的行业动态。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-01-01 Epub Date: 2024-06-28 DOI: 10.1080/17460751.2024.2365027
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in April 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2024.2365027","DOIUrl":"10.1080/17460751.2024.2365027","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in April 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CGRP promotes osteogenic differentiation by regulating macrophage M2 polarization through HDAC6/AKAP12 signaling pathway. CGRP 通过 HDAC6/AKAP12 信号通路调节巨噬细胞 M2 极化，从而促进成骨分化。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-01-01 Epub Date: 2024-07-29 DOI: 10.1080/17460751.2024.2370697
Wenjing Chen, Lin Ma, Wencai Sun, Wenlong Xiao, Hao Guo, Jiang Xiu, Xin Jiang
{"title":"CGRP promotes osteogenic differentiation by regulating macrophage M2 polarization through HDAC6/AKAP12 signaling pathway.","authors":"Wenjing Chen, Lin Ma, Wencai Sun, Wenlong Xiao, Hao Guo, Jiang Xiu, Xin Jiang","doi":"10.1080/17460751.2024.2370697","DOIUrl":"10.1080/17460751.2024.2370697","url":null,"abstract":"<p><p><b>Aim:</b> To determine the mechanism of Calcitonin gene-related peptide (CGRP) in bone healing.<b>Materials & methods:</b> Alkaline phosphatase (ALP) activity and inflammatory-factor levels were detected using ELISA. Osteogenic differentiation was assessed using Alizarin red staining technique. The interaction between histone deacetylase 6 (HDAC6) and A-kinase anchoring protein 12 (AKAP12) was investigated through Co- immunoprecipitation.<b>Results:</b> CGRP treatment promoted rat bone marrow-derived macrophages (BMDMs) M2 polarization. CGRP facilitated osteogenic differentiation by enhancing M2 polarization of BMDMs. Mechanistically, CGRP promoted AKAP12 acetylation to activate the extracellular regulated protein kinases pathway by HDAC6 inhibition.<b>Conclusion:</b> CGRP promoted M2 polarization of rat BMDMs and facilitated osteogenic differentiation through the HDAC6/AKAP12/extracellular regulated protein kinases signaling pathway, thereby promoting bone healing.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forging the way: pioneering regeneration in volume 19 of Regenerative Medicine. 锻造的方式:开拓再生医学19卷再生。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-01-01 Epub Date: 2023-11-29 DOI: 10.2217/rme-2023-0213
Jasmine Hagan, Megan Giboney
{"title":"Forging the way: pioneering regeneration in volume 19 of <i>Regenerative Medicine</i>.","authors":"Jasmine Hagan, Megan Giboney","doi":"10.2217/rme-2023-0213","DOIUrl":"10.2217/rme-2023-0213","url":null,"abstract":"<p><p>We are delighted to welcome you to the 19th volume of <i>Regenerative Medicine</i>. In this foreword, we reflect on the content highlights from 2023 and discuss what we can look forward to in the year ahead.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138452325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient, parent and professional expert perspectives on personalized regenerative implants: a qualitative focus group study. 患者、家长和专业专家对个性化再生植入物的看法：焦点小组定性研究。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-01-01 Epub Date: 2024-09-02 DOI: 10.1080/17460751.2024.2386214
Manon van Daal, Anne-Floor J de Kanter, Roel Jh Custers, Elena Martínez-Sanz, Annelien L Bredenoord, Nienke de Graeff
{"title":"Patient, parent and professional expert perspectives on personalized regenerative implants: a qualitative focus group study.","authors":"Manon van Daal, Anne-Floor J de Kanter, Roel Jh Custers, Elena Martínez-Sanz, Annelien L Bredenoord, Nienke de Graeff","doi":"10.1080/17460751.2024.2386214","DOIUrl":"10.1080/17460751.2024.2386214","url":null,"abstract":"<p><p><b>Background:</b> Perspectives of patients, parents and professional experts on personalized regenerative implants for regenerative medicine purposes are largely unknown.<b>Method:</b> To better understand these perspectives, we conducted four focus groups with professional experts of mixed European nationality (n = 8), Dutch patients with regular implants (n = 8), Dutch and Belgian (n = 5) and Spanish (n = 8) parents of children with cleft palate.<b>Results:</b> Two overarching themes were identified: 'patient-centered research and care' and 'ambivalent attitudes toward personalized regenerative implants'.<b>Discussion:</b> The results reveal that stakeholders should adopt a participatory rather than an impairment discourse and address the ambivalence among professional experts, patients and parents.<b>Conclusion:</b> Considering stakeholder perspectives facilitates ethical and responsible development and use of personalized regenerative implants.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety of bone marrow derived mesenchymal stem cell extracellular vesicle injection for lumbar facet joint pain. 骨髓间充质干细胞细胞外囊注射治疗腰椎面关节疼痛的安全性。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-01-01 Epub Date: 2024-02-08 DOI: 10.2217/rme-2023-0110
James E Wilson, Bobbie A Today, Maria Salazar, Jonathann Kuo, John T Ransom, Amy L Lightner, Grace Chen, Anita Wong
{"title":"Safety of bone marrow derived mesenchymal stem cell extracellular vesicle injection for lumbar facet joint pain.","authors":"James E Wilson, Bobbie A Today, Maria Salazar, Jonathann Kuo, John T Ransom, Amy L Lightner, Grace Chen, Anita Wong","doi":"10.2217/rme-2023-0110","DOIUrl":"10.2217/rme-2023-0110","url":null,"abstract":"<p><p><b>Aim:</b> A 3-month pilot study to evaluate the safety of injecting a bone marrow-derived mesenchymal stem cell extracellular vesicle advanced investigational product (IP) into the lumbar facet joint space as a treatment for chronic low back pain. <b>Methods:</b> 20 healthy adults were treated with IP injections (0.5 ml/joint) and evaluated by three functional assessments 1, 3, 7, 14, 30, 60 and 90 days later. <b>Results:</b> No adverse effects or complications occurred across the 3-month follow-up. There were no reports of worsening pain. After 3 months group average scores improved significantly (p < 0.0001) in the Severity Index (65.04%), Interference Index (72.09%) and Oswestry Disability Index (58.43%) assessments. <b>Conclusion:</b> IP injections were safe and associated with significant functional improvements.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduction of Activin A gives rise to comparable expression of key definitive endoderm and mature beta cell markers. 减少 Activin A 会导致关键的最终内胚层和成熟β细胞标志物的表达不相上下。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-01-01 Epub Date: 2024-01-19 DOI: 10.2217/rme-2023-0187
Aldyn Wildey, Stephen Harrington, Lisa Stehno-Bittel, Francis Karanu
{"title":"Reduction of Activin A gives rise to comparable expression of key definitive endoderm and mature beta cell markers.","authors":"Aldyn Wildey, Stephen Harrington, Lisa Stehno-Bittel, Francis Karanu","doi":"10.2217/rme-2023-0187","DOIUrl":"10.2217/rme-2023-0187","url":null,"abstract":"<p><p><b>Aim:</b> Cell therapies for diabetes rely on differentiation of stem cells into insulin-producing cells, which is complex and expensive. Our goal was to evaluate production costs and test ways to reduce it. <b>Methods:</b> Cost of Goods (COGs) analysis for differentiation was completed and the effects of replacement or reduction of the most expensive item was tested using qRT-PCR, immunohistochemistry, flow cytometry along with glucose-stimulated insulin release. <b>Results:</b> Activin A (AA) was responsible for significant cost. Replacement with small molecules failed to form definitive endoderm (DE). Reducing AA by 50% did not negatively affect expression of beta cell markers. <b>Conclusion:</b> Reduction of AA concentration is feasible without adversely affecting DE and islet-like cell differentiation, leading to significant cost savings in manufacturing.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unconventional strategies for liver tissue engineering: plant, paper, silk and nanomaterial-based scaffolds. 肝脏组织工程的非常规策略：基于植物、纸张、丝绸和纳米材料的支架。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-01-01 Epub Date: 2024-08-05 DOI: 10.1080/17460751.2024.2378615
Sanyam Jain, Jai Gopal Sharma
{"title":"Unconventional strategies for liver tissue engineering: plant, paper, silk and nanomaterial-based scaffolds.","authors":"Sanyam Jain, Jai Gopal Sharma","doi":"10.1080/17460751.2024.2378615","DOIUrl":"10.1080/17460751.2024.2378615","url":null,"abstract":"<p><p>The paper highlights how significant characteristics of liver can be modeled in tissue-engineered constructs using unconventional scaffolds. Hepatic lobular organization and metabolic zonation can be mimicked with decellularized plant structures with vasculature resembling a native-hepatic lobule vascular arrangement or silk blend scaffolds meticulously designed for guided cellular arrangement as hepatic patches or metabolic activities. The functionality of hepatocytes can be enhanced and maintained for long periods in naturally fibrous structures paving way for bioartificial liver development. The phase I enzymatic activity in hepatic models can be raised exploiting the microfibrillar structure of paper to allow cellular stacking creating hypoxic conditions to induce <i>in vivo</i>-like xenobiotic metabolism. Lastly, the paper introduces amalgamation of carbon-based nanomaterials into existing scaffolds in liver tissue engineering.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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