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Slaughterhouse waste: a unique and sustainable source for dECM-based bioinks. 屠宰场废物：基于 dECM 的生物墨水的独特和可持续来源。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-03-01 Epub Date: 2024-02-15 DOI: 10.2217/rme-2023-0194
Meklit G Shibru, Zehara M Ali, Aliyaa S Almansoori, Jovana Paunovic, Igor V Pantic, Peter R Corridon
{"title":"Slaughterhouse waste: a unique and sustainable source for dECM-based bioinks.","authors":"Meklit G Shibru, Zehara M Ali, Aliyaa S Almansoori, Jovana Paunovic, Igor V Pantic, Peter R Corridon","doi":"10.2217/rme-2023-0194","DOIUrl":"10.2217/rme-2023-0194","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"113-118"},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bibliometric analysis of organoids in regenerative medicine-related research worldwide over two decades (2002-2022). 二十年来（2002-2022 年）全球再生医学相关研究中有机体的文献计量分析。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-03-01 Epub Date: 2024-03-07 DOI: 10.2217/rme-2023-0176
Jajar Setiawan, Dicky Moch Rizal, Fajar Sofyantoro, Dwi Sendi Priyono, Nur Indah Septriani, Wulan Usfi Mafiroh, Takenori Kotani, Takashi Matozaki, Wahyu Aristyaning Putri
{"title":"Bibliometric analysis of organoids in regenerative medicine-related research worldwide over two decades (2002-2022).","authors":"Jajar Setiawan, Dicky Moch Rizal, Fajar Sofyantoro, Dwi Sendi Priyono, Nur Indah Septriani, Wulan Usfi Mafiroh, Takenori Kotani, Takashi Matozaki, Wahyu Aristyaning Putri","doi":"10.2217/rme-2023-0176","DOIUrl":"10.2217/rme-2023-0176","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to evaluate the trends in organoid culture research within the field of regenerative medicine from 2002 to 2022. <b>Methods:</b> The worldwide distribution of organoid research in regenerative medicine articles indexed in the Scopus database was analyzed. <b>Result:</b> A total of 840 documents were analyzed, averaging 42 publications annually. The USA (n = 296) led in publications, followed by China (n = 127), Japan (n = 91) and the UK (n = 75). Since 2011, research has surged, particularly in China, which emerged as a prominent center. <b>Conclusion:</b> The findings highlight significant growth in organoid research, promising future organ transplantation. Research trends integrate tissue engineering, gene modification and induced pluripotent stem cell technologies, reflecting a move toward personalized medicine.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"119-133"},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modification of the inflammatory profile of mesenchymal stem cells using different culture conditions. 利用不同的培养条件改变间充质干细胞的炎症特征。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-02-01 Epub Date: 2024-02-15 DOI: 10.2217/rme-2023-0162
Alison A Smith, Charles F Bellows
{"title":"Modification of the inflammatory profile of mesenchymal stem cells using different culture conditions.","authors":"Alison A Smith, Charles F Bellows","doi":"10.2217/rme-2023-0162","DOIUrl":"10.2217/rme-2023-0162","url":null,"abstract":"<p><p><b>Aim:</b> Mesenchymal stem cells (MSCs) are pluripotent cells with significant therapeutic potential. The objective of this study was to examine the inflammatory profile of MSCs cultured under different conditions. <b>Methods:</b> MSCs were cultured by three strategies: seeding on an extracellular matrix (ECM), spheroids in static culture and spheroids in a bioreactor. Paracrine factors and CD206, a marker of M2 macrophage phenotype, were measured. <b>Results:</b> MSCs grown as spheroids in a bioreactor produced more IL-6 and IL-8 (p < 0.05). Supernatant collected from spheroids under both culture conditions increased the M2 macrophage phenotype almost twofold. <b>Conclusion:</b> Results indicate that the inflammatory profile of the supernatant collected from MSCs can be modified through culture conditions which has impacts for the future of regenerative medicine.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"83-91"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in October 2023. 2023 年 10 月干细胞研究和再生医学领域的行业动态。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2024-02-01 Epub Date: 2024-02-09 DOI: 10.2217/rme-2024-0002
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in October 2023.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.2217/rme-2024-0002","DOIUrl":"10.2217/rme-2024-0002","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in October 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"69-82"},"PeriodicalIF":2.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139707616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ink-spiring innovations: 3D bioprinting skin models for disease discovery. 墨水激发的创新：用于疾病发现的三维生物打印皮肤模型。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-02-01 Epub Date: 2024-01-05 DOI: 10.2217/rme-2023-0216
Rafaela Mayumi Simoes Torigoe, Alexander Revzin, Andrew Badley, Saranya Wyles
{"title":"Ink-spiring innovations: 3D bioprinting skin models for disease discovery.","authors":"Rafaela Mayumi Simoes Torigoe, Alexander Revzin, Andrew Badley, Saranya Wyles","doi":"10.2217/rme-2023-0216","DOIUrl":"10.2217/rme-2023-0216","url":null,"abstract":"<p><p>Tweetable abstract Inflammatory skin diseases account for most chronic skin conditions. 3D bioprinting is an exciting technology that can revolutionize the understanding and approach to treatment of atopic dermatitis and graft-versus-host disease.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"65-68"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139098548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early delivery of human umbilical cord mesenchymal stem cells improves healing in a rat model of Achilles tendinopathy. 早期输送人脐带间充质干细胞可改善跟腱病大鼠模型的愈合。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-02-01 Epub Date: 2024-02-28 DOI: 10.2217/rme-2023-0222
Ze Yuan, Ding Yu, Yanxue Wang, Lijiaqi Liu, Junchao Wang, Chao Ma, Shaoling Wu
{"title":"Early delivery of human umbilical cord mesenchymal stem cells improves healing in a rat model of Achilles tendinopathy.","authors":"Ze Yuan, Ding Yu, Yanxue Wang, Lijiaqi Liu, Junchao Wang, Chao Ma, Shaoling Wu","doi":"10.2217/rme-2023-0222","DOIUrl":"10.2217/rme-2023-0222","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to explore the efficacy and optimal delivery time of human umbilical cord mesenchymal stem cells (hUC-MSCs) in treating collagenase-induced Achilles tendinopathy. <b>Methods:</b> Achilles tendinopathy in rats at early or advanced stages was induced by injecting collagenase I into bilateral Achilles tendons. A total of 28 injured rats were injected with a hUC-MSC solution or normal saline into bilateral tendons twice and sampled after 4 weeks for histological staining, gene expression analysis, transmission electron microscope assay and biomechanical testing analysis. <b>Results:</b> The results revealed better histological performance and a larger collagen fiber diameter in the MSC group. mRNA expression of TNF-α, IL-1β and MMP-3 was lower after MSC transplantation. Early MSC delivery promoted collagen I and TIMP-3 synthesis, and strengthened tendon toughness. <b>Conclusion:</b> hUC-MSCs demonstrated a therapeutic effect in treating collagenase-induced Achilles tendinopathy, particularly in the early stage of tendinopathy.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"93-102"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139983699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Glossary for Advanced Therapies. 高级疗法词汇》。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2024-01-16 DOI: 10.2217/rme-2023-1812s
{"title":"The Glossary for Advanced Therapies.","authors":"","doi":"10.2217/rme-2023-1812s","DOIUrl":"https://doi.org/10.2217/rme-2023-1812s","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forging the way: pioneering regeneration in volume 19 of Regenerative Medicine. 锻造的方式:开拓再生医学19卷再生。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-01-01 Epub Date: 2023-11-29 DOI: 10.2217/rme-2023-0213
Jasmine Hagan, Megan Giboney
{"title":"Forging the way: pioneering regeneration in volume 19 of <i>Regenerative Medicine</i>.","authors":"Jasmine Hagan, Megan Giboney","doi":"10.2217/rme-2023-0213","DOIUrl":"10.2217/rme-2023-0213","url":null,"abstract":"<p><p>We are delighted to welcome you to the 19th volume of <i>Regenerative Medicine</i>. In this foreword, we reflect on the content highlights from 2023 and discuss what we can look forward to in the year ahead.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-4"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138452325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CGRP promotes osteogenic differentiation by regulating macrophage M2 polarization through HDAC6/AKAP12 signaling pathway. CGRP 通过 HDAC6/AKAP12 信号通路调节巨噬细胞 M2 极化，从而促进成骨分化。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-01-01 Epub Date: 2024-07-29 DOI: 10.1080/17460751.2024.2370697
Wenjing Chen, Lin Ma, Wencai Sun, Wenlong Xiao, Hao Guo, Jiang Xiu, Xin Jiang
{"title":"CGRP promotes osteogenic differentiation by regulating macrophage M2 polarization through HDAC6/AKAP12 signaling pathway.","authors":"Wenjing Chen, Lin Ma, Wencai Sun, Wenlong Xiao, Hao Guo, Jiang Xiu, Xin Jiang","doi":"10.1080/17460751.2024.2370697","DOIUrl":"10.1080/17460751.2024.2370697","url":null,"abstract":"<p><p><b>Aim:</b> To determine the mechanism of Calcitonin gene-related peptide (CGRP) in bone healing.<b>Materials & methods:</b> Alkaline phosphatase (ALP) activity and inflammatory-factor levels were detected using ELISA. Osteogenic differentiation was assessed using Alizarin red staining technique. The interaction between histone deacetylase 6 (HDAC6) and A-kinase anchoring protein 12 (AKAP12) was investigated through Co- immunoprecipitation.<b>Results:</b> CGRP treatment promoted rat bone marrow-derived macrophages (BMDMs) M2 polarization. CGRP facilitated osteogenic differentiation by enhancing M2 polarization of BMDMs. Mechanistically, CGRP promoted AKAP12 acetylation to activate the extracellular regulated protein kinases pathway by HDAC6 inhibition.<b>Conclusion:</b> CGRP promoted M2 polarization of rat BMDMs and facilitated osteogenic differentiation through the HDAC6/AKAP12/extracellular regulated protein kinases signaling pathway, thereby promoting bone healing.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"379-391"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in April 2024. 2024 年 4 月干细胞研究和再生医学领域的行业动态。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-01-01 Epub Date: 2024-06-28 DOI: 10.1080/17460751.2024.2365027
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in April 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2024.2365027","DOIUrl":"10.1080/17460751.2024.2365027","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in April 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"365-374"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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