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miR-125b-5p alleviates the damage of myocardial infarction by inhibiting the NFAT2 to reduce F2RL2 expression. miR-125b-5p通过抑制NFAT2，降低F2RL2的表达，减轻心肌梗死的损害。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-07-01 DOI: 10.2217/rme-2022-0150
Zhenhua Wu, Jie Geng, Yunpeng Bai, Yujuan Qi, Chao Chang, Yan Jiao, Zhigang Guo
{"title":"miR-125b-5p alleviates the damage of myocardial infarction by inhibiting the <i>NFAT2</i> to reduce <i>F2RL2</i> expression.","authors":"Zhenhua Wu,&nbsp;Jie Geng,&nbsp;Yunpeng Bai,&nbsp;Yujuan Qi,&nbsp;Chao Chang,&nbsp;Yan Jiao,&nbsp;Zhigang Guo","doi":"10.2217/rme-2022-0150","DOIUrl":"https://doi.org/10.2217/rme-2022-0150","url":null,"abstract":"<p><p><b>Aim:</b> To explore the effect of miR-125b-5p/nuclear factor of activated T cells 1 (<i>NFAT2</i>)/<i>F2RL2</i> on myocardial infarction (MI). <b>Method:</b> After establishment of MI mouse model and oxygen glucose deprivation (OGD)-induced cell model, the effects of <i>NFAT2</i> on the process of MI were observed, the effects of miR-125b-5p/<i>NFAT2</i>/<i>F2RL2</i> on the cell viability, apoptosis, and inflammatory factors levels were determined. <b>Result:</b> <i>NFAT2</i> silencing relieved MI and inhibited the inflammation in MI model mice. In OGD-induced human coronary artery endothelial cells and human cardiac microvascular endothelial cells, miR-125b-5p enhanced cell viability, yet repressed cell apoptosis and inflammatory factors and NFAT2 levels. NFAT2 overexpression reversed the effects of miR-125b-5p, while <i>F2RL2</i> silencing offset the effects of NFAT2 overexpression. <b>Conclusion:</b> MiR-125b-5p alleviates MI injury by inhibiting <i>NFAT2</i> level to reduce <i>F2RL2</i> expression.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 7","pages":"543-559"},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10112394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in March 2023. 2023年3月来自干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-07-01 DOI: 10.2217/rme-2023-0067
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in March 2023.","authors":"Dusko Ilic,&nbsp;Mirjana Liovic","doi":"10.2217/rme-2023-0067","DOIUrl":"https://doi.org/10.2217/rme-2023-0067","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in March 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 7","pages":"515-525"},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9689153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How proven is a 'proven intervention'? Ethics of placebo controls in light of conditional approval programs. “经过验证的干预措施”有多成熟?根据有条件批准程序，安慰剂控制的伦理学。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-07-01 Epub Date: 2023-06-21 DOI: 10.2217/rme-2022-0021
Kristina Hug
{"title":"How proven is a 'proven intervention'? Ethics of placebo controls in light of conditional approval programs.","authors":"Kristina Hug","doi":"10.2217/rme-2022-0021","DOIUrl":"10.2217/rme-2022-0021","url":null,"abstract":"<p><p>This article discusses the difficulties of establishing whether there exists a proven therapeutic intervention when regenerative experimental treatments are made accessible to patients under conditional approval programs (outside clinical trials). Conditional approvals are often made on the basis of less robust efficacy evidence than otherwise required for the registration of new treatments. Lower quality of evidence affects the ethical justification of using a placebo-control design. The absence of a proven intervention is important in evaluating whether it is ethically justifiable to use such a design in a clinical trial and is present in major ethical guidelines. The main argument in this paper is that conditionally approved therapies, if referred to as 'proven interventions', would make placebo-control design ethically unjustifiable. Conducting rigorous clinical trials after conditional approvals is crucial to establish the efficacy of therapeutic approaches under such approvals. Hindrances to running such trials and generating further efficacy evidence are brought to attention.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 7","pages":"561-572"},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9697342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of decellularization using sodium dodecyl sulfate on glycosaminoglycans content in the liver. 十二烷基硫酸钠脱细胞对肝脏中糖胺聚糖含量的影响。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-07-01 DOI: 10.2217/rme-2023-0050
Meghana Kasturi, Kirthanashri S Vasanthan
{"title":"Effect of decellularization using sodium dodecyl sulfate on glycosaminoglycans content in the liver.","authors":"Meghana Kasturi,&nbsp;Kirthanashri S Vasanthan","doi":"10.2217/rme-2023-0050","DOIUrl":"https://doi.org/10.2217/rme-2023-0050","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 7","pages":"527-530"},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9726929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the reporting of harms in systematic reviews focused on platelet-rich plasma therapy: a cross-sectional analysis. 评估富血小板血浆治疗系统评价中危害报告:一项横断面分析
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-07-01 DOI: 10.2217/rme-2023-0058
Shaelyn Ward, Kade Ezell, Audrey Wise, Morgan Garrett, Brayden Rucker, Drew Lestersmith, Mohammed Emam, Matt Vassar
{"title":"Assessing the reporting of harms in systematic reviews focused on platelet-rich plasma therapy: a cross-sectional analysis.","authors":"Shaelyn Ward,&nbsp;Kade Ezell,&nbsp;Audrey Wise,&nbsp;Morgan Garrett,&nbsp;Brayden Rucker,&nbsp;Drew Lestersmith,&nbsp;Mohammed Emam,&nbsp;Matt Vassar","doi":"10.2217/rme-2023-0058","DOIUrl":"https://doi.org/10.2217/rme-2023-0058","url":null,"abstract":"<p><p><b>Aim:</b> Our objectives are: to evaluate the completeness of harms reporting in systematic reviews (SRs) on platelet-rich plasma therapy; to assess the overall methodological quality of the SR using AMSTAR-2 tool; to assess harms reporting overlap in primary studies between SRs. <b>Materials & methods:</b> The authors searched five database systems for relevant literature on platelet rich plasma therapy. The authors screened and extracted in masked, duplicate fashion. <b>Results:</b> All SRs reported less than 50% completeness in harms reporting. The most frequently reported item was harms being stated in the abstract or title (26/103, 25.2%). AMSTAR-2 assessed 96 SRs as 'critically low', 6 SRs as 'low' and 1 'moderate'. <b>Conclusion:</b> Our study highlights that reporting of harms should become more standardized and transparent.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 7","pages":"531-542"},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10112390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive analysis of culture conditions governing differentiation of MSCs into articular chondrocytes. 骨髓间充质干细胞向关节软骨细胞分化的培养条件综合分析。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-07-01 DOI: 10.2217/rme-2023-0017
Harsh Vikram Singh, Lakshmana Das, Rhuthuparna Malayil, Tashvinder Singh, Sandeep Singh, Tarun Goyal, Anjana Munshi
{"title":"Comprehensive analysis of culture conditions governing differentiation of MSCs into articular chondrocytes.","authors":"Harsh Vikram Singh,&nbsp;Lakshmana Das,&nbsp;Rhuthuparna Malayil,&nbsp;Tashvinder Singh,&nbsp;Sandeep Singh,&nbsp;Tarun Goyal,&nbsp;Anjana Munshi","doi":"10.2217/rme-2023-0017","DOIUrl":"https://doi.org/10.2217/rme-2023-0017","url":null,"abstract":"<p><p>Treatment of osteoarthritic patients requires the development of morphologically and mechanically complex hyaline cartilage at the injury site. A tissue engineering approach toward differentiating mesenchymal stem cells into articular chondrocytes has been developed to overcome the drawbacks of conventional therapeutic and surgical procedures. To imitate the native micro and macro environment of articular chondrocytes, cell culture parameters such as oxygen concentration, mechanical stress, scaffold design, and growth factor signalling cascade regulation must be addressed. This review aims to illuminate the path toward developing tissue engineering approaches, accommodating these various parameters and the role these parameters play in regulating chondrogenesis for better articular cartilage development to treat osteoarthritis effectively.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 7","pages":"573-590"},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9731817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astragaloside-IV induces the differentiation of bone marrow mesenchymal stem cells into osteoblasts through NMUR2-mediated Wnt/β-catenin pathway. 黄芪甲苷通过nmur2介导的Wnt/β-catenin通路诱导骨髓间充质干细胞向成骨细胞分化。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-06-01 DOI: 10.2217/rme-2022-0184
Yujing Cao, Qiuxia Lv, Zhihui Huang, Yang Li
{"title":"Astragaloside-IV induces the differentiation of bone marrow mesenchymal stem cells into osteoblasts through <i>NMUR2</i>-mediated Wnt/β-catenin pathway.","authors":"Yujing Cao,&nbsp;Qiuxia Lv,&nbsp;Zhihui Huang,&nbsp;Yang Li","doi":"10.2217/rme-2022-0184","DOIUrl":"https://doi.org/10.2217/rme-2022-0184","url":null,"abstract":"<p><p><b>Aim:</b> Given that astragaloside-IV (As-IV) has the ability to promote osteogenic differentiation, its mechanism is worthy of exploration. <b>Methods:</b> The effect of As-IV on rat tibial defects was examined by histopathological staining and MiR-CT scan. The alkaline phosphatase (ALP) content, osteogenic differentiation-related gene expressions, and mineralized nodule formation in bone marrow mesenchymal stem cells (BMSCs) were detected. <b>Results:</b> As-IV repaired tibial defects of rats. As-IV or neuromedin receptor 2 (<i>NMUR2</i>) overexpression elevated ALP content, mineralized nodules, osteogenic differentiation-related genes, β-catenin and <i>NMUR2</i> levels, the effects of which were reversed by <i>NMUR2</i> silencing or Wnt/β-catenin pathway inhibitors. <b>Conclusion:</b> As-IV regulates the Wnt/β-catenin pathway through <i>NMUR2</i> to promote the repair of tibial defects in rats and the differentiation of BMSCs into osteoblasts.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 6","pages":"471-485"},"PeriodicalIF":2.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10044401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pseudoseptic reaction to an intra-articular platelet-rich plasma injection into the knee: a case report. 膝关节内关节内富血小板血浆注射的假性化脓性反应:1例报告。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-06-01 DOI: 10.2217/rme-2022-0216
Kyungje Sung, Kevin Zheng, Chris Williams, David Cunningham, Walter I Sussman
{"title":"Pseudoseptic reaction to an intra-articular platelet-rich plasma injection into the knee: a case report.","authors":"Kyungje Sung,&nbsp;Kevin Zheng,&nbsp;Chris Williams,&nbsp;David Cunningham,&nbsp;Walter I Sussman","doi":"10.2217/rme-2022-0216","DOIUrl":"https://doi.org/10.2217/rme-2022-0216","url":null,"abstract":"<p><p>A variety of intra-articular injections are used for the management of osteoarthritis. A rare complication of intra-articular injections is acute pseudoseptic arthritis, which mimics true septic arthritis. To the authors knowledge, pseudosepsis has not been reported as a complication after platelet-rich plasma (PRP) injections. We present a case report of pseudoseptic arthritis resulting in acute postinjection pain and a joint effusion after an intra-articular PRP injection into the knee. Clinically, pseudosepsis can occur after PRP treatment with significantly elevated white blood cell counts in the synovial fluid, and should be a consideration in cases of post-PRP injection flares.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 6","pages":"455-459"},"PeriodicalIF":2.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9678678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in February 2023. 2023年2月来自干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-06-01 DOI: 10.2217/rme-2023-0053
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in February 2023.","authors":"Dusko Ilic,&nbsp;Mirjana Liovic","doi":"10.2217/rme-2023-0053","DOIUrl":"https://doi.org/10.2217/rme-2023-0053","url":null,"abstract":"Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in February 2023.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 6","pages":"443-453"},"PeriodicalIF":2.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9663016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Derivation of a clinical decision rule for a bone marrow aspirate concentrate injection in knee osteoarthritis. 骨髓浓缩液注射治疗膝骨关节炎的临床决策规则的推导。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-06-01 DOI: 10.2217/rme-2023-0014
Ashley D Smith, Dasan Sydora, Robert Burnham
{"title":"Derivation of a clinical decision rule for a bone marrow aspirate concentrate injection in knee osteoarthritis.","authors":"Ashley D Smith,&nbsp;Dasan Sydora,&nbsp;Robert Burnham","doi":"10.2217/rme-2023-0014","DOIUrl":"https://doi.org/10.2217/rme-2023-0014","url":null,"abstract":"<p><p><b>Aim:</b> To develop a simple clinical decision rule (CDR) to identify people with knee osteoarthritis who are likely or unlikely to benefit from bone marrow aspirate concentrate (BMAC) injection. <b>Materials & methods:</b> A total of 92 people with clinical and radiographic evidence of refractory knee osteoarthritis received a single intra-articular (IA) BMAC injection. Multiple logistic regression analysis was used to determine which combination of risk factors predicted BMAC responsiveness. A responder was defined as a person whose knee pain improved more than 15% from baseline 6 months post procedure. <b>Results:</b> The CDR demonstrated that those with lower pain levels, or high pain levels with previous surgery, could be predicted to benefit from a single IA BMAC injection. <b>Conclusion:</b> A simple CDR containing three variables predicted responsiveness to a single IA knee BMAC injection with high accuracy. Further validation of the CDR is required prior to routine use in clinical practice.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 6","pages":"461-470"},"PeriodicalIF":2.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9678696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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