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From fetal tendon regeneration to adult therapeutic modalities: TGF-β3 in scarless healing. 从胎儿肌腱再生到成人治疗模式：TGF-β3在无瘢痕愈合中的作用。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-10-01 Epub Date: 2023-09-06 DOI: 10.2217/rme-2023-0145
Hanyue Li, Shengyu Luo, Hongtao Li, Hongyu Pan, Li Jiang, Yixuan Chen, Hui Chen, Zhenhua Feng, Sen Li
{"title":"From fetal tendon regeneration to adult therapeutic modalities: TGF-β3 in scarless healing.","authors":"Hanyue Li,&nbsp;Shengyu Luo,&nbsp;Hongtao Li,&nbsp;Hongyu Pan,&nbsp;Li Jiang,&nbsp;Yixuan Chen,&nbsp;Hui Chen,&nbsp;Zhenhua Feng,&nbsp;Sen Li","doi":"10.2217/rme-2023-0145","DOIUrl":"10.2217/rme-2023-0145","url":null,"abstract":"<p><p>Tendon injuries are common disorders that can significantly impact people's lives. Unfortunately, the limited regenerative ability of tendons results in tissue healing in a scar-mediated manner. The current therapeutic strategies fail to fully recover the functions of the injured tendons, and as such, the conception of 'scarless healing' has gained prominent attention in the field of regenerative medicine. Interestingly, injured fetal tendons possess the capability to heal through regeneration, which builds an ideal blueprint for adult tendon regeneration. Studies have shown that fetal biochemical cues have the potential to improve adult tendon healing. Here we review the biological factors that contribute to fetal tendon regeneration and how manipulation of these biochemical cues in the adult tendon healing process could achieve regeneration.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"809-822"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10163308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in June 2023. 2023年6月，干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-10-01 Epub Date: 2023-08-09 DOI: 10.2217/rme-2023-0152
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in June 2023.","authors":"Dusko Ilic,&nbsp;Mirjana Liovic","doi":"10.2217/rme-2023-0152","DOIUrl":"10.2217/rme-2023-0152","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in June 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"759-772"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9959912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential of mesenchymal stem cell-derived conditioned medium/secretome as a therapeutic option for ocular diseases. 间充质干细胞衍生的条件培养基/分泌组作为眼部疾病治疗选择的潜力。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-10-01 Epub Date: 2023-09-13 DOI: 10.2217/rme-2023-0089
Wesley Harrisson Bouche Djatche, Huimin Zhu, Wenlei Ma, Yue Li, Ziang Li, Hong Zhao, Zhizhen Liu, Hua Qiao
{"title":"Potential of mesenchymal stem cell-derived conditioned medium/secretome as a therapeutic option for ocular diseases.","authors":"Wesley Harrisson Bouche Djatche,&nbsp;Huimin Zhu,&nbsp;Wenlei Ma,&nbsp;Yue Li,&nbsp;Ziang Li,&nbsp;Hong Zhao,&nbsp;Zhizhen Liu,&nbsp;Hua Qiao","doi":"10.2217/rme-2023-0089","DOIUrl":"10.2217/rme-2023-0089","url":null,"abstract":"<p><p>Research has shown that the therapeutic effect of mesenchymal stem cells (MSCs) is partially due to its secreted factors as opposed to the implantation of the cells into the treated tissue or tissue replacement. MSC secretome, especially in the form of conditioned medium (MSC-CM) is now being explored as an alternative to MSCs transplantation. Despite the observed benefits of MSC-CM, only a few clinical trials have evaluated it and other secretome components in the treatment of eye diseases. This review provides insight into the potential therapeutic use of MSC-CM in eye conditions, such as corneal diseases, dry eye, glaucoma, retinal diseases and uveitis. We discuss the current evidence, some limitations, and the progress that remains to be achieved before clinical translation becomes possible.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"795-807"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10221650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling new trends in bone regeneration, using the BERTopic approach. 利用BERTopic方法对骨再生的新趋势进行建模。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0096
Stefano Guizzardi, Maria Teresa Colangelo, Prisco Mirandola, Carlo Galli
{"title":"Modeling new trends in bone regeneration, using the BERTopic approach.","authors":"Stefano Guizzardi,&nbsp;Maria Teresa Colangelo,&nbsp;Prisco Mirandola,&nbsp;Carlo Galli","doi":"10.2217/rme-2023-0096","DOIUrl":"https://doi.org/10.2217/rme-2023-0096","url":null,"abstract":"<p><p><b>Aim:</b> Bibliometric surveys are time-consuming endeavors, which cannot be scaled up to meet the challenges of ever-expanding fields, such as bone regeneration. Artificial intelligence, however, can provide smart tools to screen massive amounts of literature, and we relied on this technology to automatically identify research topics. <b>Materials & methods:</b> We used the BERTopic algorithm to detect the topics in a corpus of MEDLINE manuscripts, mapping their similarities and highlighting research hotspots. <b>Results:</b> Using BERTopic, we identified 372 topics and were able to assess the growing importance of innovative and recent fields of investigation such as 3D printing and extracellular vescicles. <b>Conclusion:</b> BERTopic appears as a suitable tool to set up automatic screening routines to track the progress in bone regeneration.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 9","pages":"719-734"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10273546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of transplantation of umbilical cord blood mononuclear cells into the scrotum on sexual function in elderly mice. 脐血单核细胞阴囊移植对老年小鼠性功能的影响。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2022-0191
Jun Li, Yinghong Jiang, Wei Xue, Lejiang Liu, Hua Yu, Xuemei Zhang, Xiao Ye, Jianrong Miao, Jianling Liu, Yueen Chen, Xingbin Lan, Xiaoqing Liu, Wensong Yao, Jianchuan Sun, Jing Zheng, Jianzhong Xiao
{"title":"Effects of transplantation of umbilical cord blood mononuclear cells into the scrotum on sexual function in elderly mice.","authors":"Jun Li,&nbsp;Yinghong Jiang,&nbsp;Wei Xue,&nbsp;Lejiang Liu,&nbsp;Hua Yu,&nbsp;Xuemei Zhang,&nbsp;Xiao Ye,&nbsp;Jianrong Miao,&nbsp;Jianling Liu,&nbsp;Yueen Chen,&nbsp;Xingbin Lan,&nbsp;Xiaoqing Liu,&nbsp;Wensong Yao,&nbsp;Jianchuan Sun,&nbsp;Jing Zheng,&nbsp;Jianzhong Xiao","doi":"10.2217/rme-2022-0191","DOIUrl":"https://doi.org/10.2217/rme-2022-0191","url":null,"abstract":"<p><p><b>Aim:</b> This study investigated the effect of allografting umbilical cord blood mononuclear cells (UCBMCs) into the scrotum on sexual function in male elderly mice. <b>Methods:</b> UCBMCs were injected once into the scrotal sheath cavity of elderly mice. <b>Results:</b> The transplanted UCBMCs survived in the scrotal sheath cavity for 1 month. The mice had significantly increased blood testosterone concentrations, cyclic guanosine monophosphate (cGMP) levels and total nitric oxide synthase (T-NOS) activity in the corpus cavernosum and an increase in the number of mouse matings within 30 min (all p = 0.000). <b>Conclusion:</b> Scrotum-implanted UCBMCs improve the sexual function of male elderly mice through testosterone production and the NOS/cGMP pathway, which may provide an innovative transplantation approach for the treatment of erectile dysfunction.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 9","pages":"695-706"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10221217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hope on the horizon: Wharton's jelly mesenchymal stem cells in the fight against COVID-19. 希望在地平线上:沃顿的果冻间充质干细胞在对抗COVID-19的斗争中。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0077
Gaurav Gupta, Md Sadique Hussain, Riya Thapa, Rajiv Dahiya, Debarshi Kar Mahapatra, Asif Ahmad Bhat, Neelam Singla, Vetriselvan Subramaniyan, Sushama Rawat, Vikas Jakhmola, Roshan S, Kamal Dua
{"title":"Hope on the horizon: Wharton's jelly mesenchymal stem cells in the fight against COVID-19.","authors":"Gaurav Gupta,&nbsp;Md Sadique Hussain,&nbsp;Riya Thapa,&nbsp;Rajiv Dahiya,&nbsp;Debarshi Kar Mahapatra,&nbsp;Asif Ahmad Bhat,&nbsp;Neelam Singla,&nbsp;Vetriselvan Subramaniyan,&nbsp;Sushama Rawat,&nbsp;Vikas Jakhmola,&nbsp;Roshan S,&nbsp;Kamal Dua","doi":"10.2217/rme-2023-0077","DOIUrl":"https://doi.org/10.2217/rme-2023-0077","url":null,"abstract":"of","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 9","pages":"675-678"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10219290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Perfusion in vivo bioreactor promotes regeneration of vascularized tissue-engineered bone. 体内生物反应器灌注促进血管化组织工程骨的再生。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0101
Peng Liu, Jian Wang, Yun Xue, Lei Zou, Yongzheng Tian, Ruilong Sun, Wenhua Zhang, Yunfei Li, Lijun Lv, Qiuming Gao, Bo Fan
{"title":"Perfusion <i>in vivo</i> bioreactor promotes regeneration of vascularized tissue-engineered bone.","authors":"Peng Liu,&nbsp;Jian Wang,&nbsp;Yun Xue,&nbsp;Lei Zou,&nbsp;Yongzheng Tian,&nbsp;Ruilong Sun,&nbsp;Wenhua Zhang,&nbsp;Yunfei Li,&nbsp;Lijun Lv,&nbsp;Qiuming Gao,&nbsp;Bo Fan","doi":"10.2217/rme-2023-0101","DOIUrl":"https://doi.org/10.2217/rme-2023-0101","url":null,"abstract":"<p><p><b>Aim:</b> This study improved the <i>in vivo</i> bioreactor (IVB) for bone regeneration by enhancing stem cell survival and promoting vascularized tissue-engineered bone. <b>Methods:</b> 12 New Zealand rabbits received β-TCP scaffolds with rabbit bone mesenchymal stem cells (BMSCs) implanted. Perfusion IVB with a perfusion electronic pump was compared with the control group using micro-CT, Microfil perfusion, histological staining and RT-PCR for gene expression. <b>Results:</b> Perfusion IVB demonstrated good biocompatibility, increased neoplastic bone tissue, neovascularization and upregulated osteogenic and angiogenesis-related genes in rabbits (p < 0.05). <b>Conclusion:</b> Perfusion IVB holds promise for bone regeneration and tissue engineering in orthopedics and maxillofacial surgery.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 9","pages":"707-718"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10219743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in May 2023. 2023年5月来自干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0111
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in May 2023.","authors":"Dusko Ilic,&nbsp;Mirjana Liovic","doi":"10.2217/rme-2023-0111","DOIUrl":"https://doi.org/10.2217/rme-2023-0111","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in May 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 9","pages":"681-694"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10498275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on 'Digital transformation of medical education: innovative pedagogy and regenerative surgery in the era of COVID-19'. 评论“医学教育的数字化转型:新冠肺炎时代的创新教学法和再生外科”。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0081
Evelyn Casilla-Huamán
{"title":"Comment on <i>'Digital transformation of medical education: innovative pedagogy and regenerative surgery in the era of COVID-19</i>'.","authors":"Evelyn Casilla-Huamán","doi":"10.2217/rme-2023-0081","DOIUrl":"https://doi.org/10.2217/rme-2023-0081","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 9","pages":"679-680"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10219740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current evidence on mesenchymal stem cells for hip osteoarthritis: a narrative review. 间充质干细胞治疗髋关节骨关节炎的最新证据:叙述性回顾。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0071
Mina Entessari, Leonardo P Oliveira
{"title":"Current evidence on mesenchymal stem cells for hip osteoarthritis: a narrative review.","authors":"Mina Entessari,&nbsp;Leonardo P Oliveira","doi":"10.2217/rme-2023-0071","DOIUrl":"https://doi.org/10.2217/rme-2023-0071","url":null,"abstract":"<p><p>There are limited data on the use of mesenchymal stem cell injections for hip osteoarthritis. The goal of this study was to evaluate the literature by analyzing outcomes and comparing methodologies. Online search of PubMed, SportsDiscus and Case Reports Keywords was completed using the keywords 'stem cells' and 'hip' and 'osteoarthritis'. Six studies met the inclusion and exclusion criteria. Five out the six studies had statistically significant improvement in patient reported outcomes after mesenchymal stem cell injections. Only two studies provided information on radiological changes and findings were positive. None of the studies reported major complications. Small series of non-randomized controlled trials completed to date in the use of mesenchymal stem cells for the treatment of hip osteoarthritis reported the procedures to be safe and provide a positive clinical response. Randomized controlled trials must be performed to further confirm mesenchymal stem cells as a treatment option for hip osteoarthritis.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 9","pages":"749-758"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10273075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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