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Assessing the reporting of harms in systematic reviews focused on platelet-rich plasma therapy: a cross-sectional analysis. 评估富血小板血浆治疗系统评价中危害报告:一项横断面分析
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-07-01 DOI: 10.2217/rme-2023-0058
Shaelyn Ward, Kade Ezell, Audrey Wise, Morgan Garrett, Brayden Rucker, Drew Lestersmith, Mohammed Emam, Matt Vassar
{"title":"Assessing the reporting of harms in systematic reviews focused on platelet-rich plasma therapy: a cross-sectional analysis.","authors":"Shaelyn Ward,&nbsp;Kade Ezell,&nbsp;Audrey Wise,&nbsp;Morgan Garrett,&nbsp;Brayden Rucker,&nbsp;Drew Lestersmith,&nbsp;Mohammed Emam,&nbsp;Matt Vassar","doi":"10.2217/rme-2023-0058","DOIUrl":"https://doi.org/10.2217/rme-2023-0058","url":null,"abstract":"<p><p><b>Aim:</b> Our objectives are: to evaluate the completeness of harms reporting in systematic reviews (SRs) on platelet-rich plasma therapy; to assess the overall methodological quality of the SR using AMSTAR-2 tool; to assess harms reporting overlap in primary studies between SRs. <b>Materials & methods:</b> The authors searched five database systems for relevant literature on platelet rich plasma therapy. The authors screened and extracted in masked, duplicate fashion. <b>Results:</b> All SRs reported less than 50% completeness in harms reporting. The most frequently reported item was harms being stated in the abstract or title (26/103, 25.2%). AMSTAR-2 assessed 96 SRs as 'critically low', 6 SRs as 'low' and 1 'moderate'. <b>Conclusion:</b> Our study highlights that reporting of harms should become more standardized and transparent.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10112390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive analysis of culture conditions governing differentiation of MSCs into articular chondrocytes. 骨髓间充质干细胞向关节软骨细胞分化的培养条件综合分析。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-07-01 DOI: 10.2217/rme-2023-0017
Harsh Vikram Singh, Lakshmana Das, Rhuthuparna Malayil, Tashvinder Singh, Sandeep Singh, Tarun Goyal, Anjana Munshi
{"title":"Comprehensive analysis of culture conditions governing differentiation of MSCs into articular chondrocytes.","authors":"Harsh Vikram Singh,&nbsp;Lakshmana Das,&nbsp;Rhuthuparna Malayil,&nbsp;Tashvinder Singh,&nbsp;Sandeep Singh,&nbsp;Tarun Goyal,&nbsp;Anjana Munshi","doi":"10.2217/rme-2023-0017","DOIUrl":"https://doi.org/10.2217/rme-2023-0017","url":null,"abstract":"<p><p>Treatment of osteoarthritic patients requires the development of morphologically and mechanically complex hyaline cartilage at the injury site. A tissue engineering approach toward differentiating mesenchymal stem cells into articular chondrocytes has been developed to overcome the drawbacks of conventional therapeutic and surgical procedures. To imitate the native micro and macro environment of articular chondrocytes, cell culture parameters such as oxygen concentration, mechanical stress, scaffold design, and growth factor signalling cascade regulation must be addressed. This review aims to illuminate the path toward developing tissue engineering approaches, accommodating these various parameters and the role these parameters play in regulating chondrogenesis for better articular cartilage development to treat osteoarthritis effectively.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9731817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astragaloside-IV induces the differentiation of bone marrow mesenchymal stem cells into osteoblasts through NMUR2-mediated Wnt/β-catenin pathway. 黄芪甲苷通过nmur2介导的Wnt/β-catenin通路诱导骨髓间充质干细胞向成骨细胞分化。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-06-01 DOI: 10.2217/rme-2022-0184
Yujing Cao, Qiuxia Lv, Zhihui Huang, Yang Li
{"title":"Astragaloside-IV induces the differentiation of bone marrow mesenchymal stem cells into osteoblasts through <i>NMUR2</i>-mediated Wnt/β-catenin pathway.","authors":"Yujing Cao,&nbsp;Qiuxia Lv,&nbsp;Zhihui Huang,&nbsp;Yang Li","doi":"10.2217/rme-2022-0184","DOIUrl":"https://doi.org/10.2217/rme-2022-0184","url":null,"abstract":"<p><p><b>Aim:</b> Given that astragaloside-IV (As-IV) has the ability to promote osteogenic differentiation, its mechanism is worthy of exploration. <b>Methods:</b> The effect of As-IV on rat tibial defects was examined by histopathological staining and MiR-CT scan. The alkaline phosphatase (ALP) content, osteogenic differentiation-related gene expressions, and mineralized nodule formation in bone marrow mesenchymal stem cells (BMSCs) were detected. <b>Results:</b> As-IV repaired tibial defects of rats. As-IV or neuromedin receptor 2 (<i>NMUR2</i>) overexpression elevated ALP content, mineralized nodules, osteogenic differentiation-related genes, β-catenin and <i>NMUR2</i> levels, the effects of which were reversed by <i>NMUR2</i> silencing or Wnt/β-catenin pathway inhibitors. <b>Conclusion:</b> As-IV regulates the Wnt/β-catenin pathway through <i>NMUR2</i> to promote the repair of tibial defects in rats and the differentiation of BMSCs into osteoblasts.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10044401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pseudoseptic reaction to an intra-articular platelet-rich plasma injection into the knee: a case report. 膝关节内关节内富血小板血浆注射的假性化脓性反应:1例报告。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-06-01 DOI: 10.2217/rme-2022-0216
Kyungje Sung, Kevin Zheng, Chris Williams, David Cunningham, Walter I Sussman
{"title":"Pseudoseptic reaction to an intra-articular platelet-rich plasma injection into the knee: a case report.","authors":"Kyungje Sung,&nbsp;Kevin Zheng,&nbsp;Chris Williams,&nbsp;David Cunningham,&nbsp;Walter I Sussman","doi":"10.2217/rme-2022-0216","DOIUrl":"https://doi.org/10.2217/rme-2022-0216","url":null,"abstract":"<p><p>A variety of intra-articular injections are used for the management of osteoarthritis. A rare complication of intra-articular injections is acute pseudoseptic arthritis, which mimics true septic arthritis. To the authors knowledge, pseudosepsis has not been reported as a complication after platelet-rich plasma (PRP) injections. We present a case report of pseudoseptic arthritis resulting in acute postinjection pain and a joint effusion after an intra-articular PRP injection into the knee. Clinically, pseudosepsis can occur after PRP treatment with significantly elevated white blood cell counts in the synovial fluid, and should be a consideration in cases of post-PRP injection flares.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9678678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in February 2023. 2023年2月来自干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-06-01 DOI: 10.2217/rme-2023-0053
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in February 2023.","authors":"Dusko Ilic,&nbsp;Mirjana Liovic","doi":"10.2217/rme-2023-0053","DOIUrl":"https://doi.org/10.2217/rme-2023-0053","url":null,"abstract":"Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in February 2023.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9663016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Derivation of a clinical decision rule for a bone marrow aspirate concentrate injection in knee osteoarthritis. 骨髓浓缩液注射治疗膝骨关节炎的临床决策规则的推导。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-06-01 DOI: 10.2217/rme-2023-0014
Ashley D Smith, Dasan Sydora, Robert Burnham
{"title":"Derivation of a clinical decision rule for a bone marrow aspirate concentrate injection in knee osteoarthritis.","authors":"Ashley D Smith,&nbsp;Dasan Sydora,&nbsp;Robert Burnham","doi":"10.2217/rme-2023-0014","DOIUrl":"https://doi.org/10.2217/rme-2023-0014","url":null,"abstract":"<p><p><b>Aim:</b> To develop a simple clinical decision rule (CDR) to identify people with knee osteoarthritis who are likely or unlikely to benefit from bone marrow aspirate concentrate (BMAC) injection. <b>Materials & methods:</b> A total of 92 people with clinical and radiographic evidence of refractory knee osteoarthritis received a single intra-articular (IA) BMAC injection. Multiple logistic regression analysis was used to determine which combination of risk factors predicted BMAC responsiveness. A responder was defined as a person whose knee pain improved more than 15% from baseline 6 months post procedure. <b>Results:</b> The CDR demonstrated that those with lower pain levels, or high pain levels with previous surgery, could be predicted to benefit from a single IA BMAC injection. <b>Conclusion:</b> A simple CDR containing three variables predicted responsiveness to a single IA knee BMAC injection with high accuracy. Further validation of the CDR is required prior to routine use in clinical practice.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9678696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of platelet-rich plasma for sacroiliac joint dysfunction: a qualitative systematic review with pooled analysis. 富血小板血浆治疗骶髂关节功能障碍的疗效:一项综合分析的定性系统评价。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-06-01 DOI: 10.2217/rme-2022-0211
Brandon Goodwin, Nicholas Averell, Usmaan Al-Shehab, Akhmad Ernazarov, Lisa Price, Akhil Choudhary, Richard Jermyn
{"title":"Efficacy of platelet-rich plasma for sacroiliac joint dysfunction: a qualitative systematic review with pooled analysis.","authors":"Brandon Goodwin,&nbsp;Nicholas Averell,&nbsp;Usmaan Al-Shehab,&nbsp;Akhmad Ernazarov,&nbsp;Lisa Price,&nbsp;Akhil Choudhary,&nbsp;Richard Jermyn","doi":"10.2217/rme-2022-0211","DOIUrl":"https://doi.org/10.2217/rme-2022-0211","url":null,"abstract":"<p><p><b>Aim:</b> We aimed to expound upon previous research examining the effect of platelet rich plasma in the treatment of sacroiliac joint (SIJ) dysfunction and pain. <b>Materials & methods:</b> A systematic review was employed in conjunction with a pooled analysis of the efficacy of platelet-rich plasma (PRP) in SIJ dysfunction and pain. <b>Results:</b> A total of 259 articles were retrieved following database systematic review. As a result, four clinical trials and two case studies were subjected to full text appraisal. The dates of publication ranged from 2015 to 2022. <b>Conclusion:</b> Although a unique modality, there is not enough evidence to support the employment of PRP injections over current steroid standard of care. Further double-blinded, randomized control trials are required to elucidate PRP role in SIJ dysfunction.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9690830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Critical elements in tissue engineering of craniofacial malformations. 颅面畸形组织工程的关键因素。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-06-01 DOI: 10.2217/rme-2022-0128
Ali Gholamalizadeh, Sajed Nazifkerdar, Nasim Safdarian, Aida Eyvaz Ziaee, Hamid Mobedi, Reza Rahbarghazi, Mehdi Khanmohammadi, Sepideh Saghati
{"title":"Critical elements in tissue engineering of craniofacial malformations.","authors":"Ali Gholamalizadeh,&nbsp;Sajed Nazifkerdar,&nbsp;Nasim Safdarian,&nbsp;Aida Eyvaz Ziaee,&nbsp;Hamid Mobedi,&nbsp;Reza Rahbarghazi,&nbsp;Mehdi Khanmohammadi,&nbsp;Sepideh Saghati","doi":"10.2217/rme-2022-0128","DOIUrl":"https://doi.org/10.2217/rme-2022-0128","url":null,"abstract":"<p><p>Abnormal craniofacial bone fusion can lead to the generation of several congenital malformations such as cleft palate, craniosynostosis and craniofacial skeletal hypoplasia, which physically and mentally affect patients. Conventional approaches for the treatment of craniofacial malformations such as the transplantation of autologous bone grafts are not completely efficient and usually, patients suffer from various complications. In line with these statements, the advent of novel therapeutic approaches in human medicine is mandatory. Regarding the extent, size and severity of the bone malformation, supplementation and release of oxygen molecules into the affected sites are critical issues for successful osteogenesis. Here, tissue engineering modalities associated with oxygen supplementation and novel approaches associated with hydrogel synthesis were highlighted in terms of craniofacial malformations.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9687810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of mesenchymal stem cells derived from bone marrow and adipose tissue enhances bone repair in rat calvarial defects. 骨髓间充质干细胞与脂肪组织的结合促进了大鼠颅骨缺损的骨修复。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-05-01 DOI: 10.2217/rme-2022-0219
Gabriela Guaraldo Campos Totoli, Rayana Longo Bighetti-Trevisan, Gileade Pereira Freitas, Leticia Faustino Adolpho, Adriana Luisa Golçalves Almeida, Ana Carolina Loyola Barbosa, Jaqueline Isadora Reis Ramos, Marcio Mateus Beloti, Adalberto Luiz Rosa
{"title":"Association of mesenchymal stem cells derived from bone marrow and adipose tissue enhances bone repair in rat calvarial defects.","authors":"Gabriela Guaraldo Campos Totoli,&nbsp;Rayana Longo Bighetti-Trevisan,&nbsp;Gileade Pereira Freitas,&nbsp;Leticia Faustino Adolpho,&nbsp;Adriana Luisa Golçalves Almeida,&nbsp;Ana Carolina Loyola Barbosa,&nbsp;Jaqueline Isadora Reis Ramos,&nbsp;Marcio Mateus Beloti,&nbsp;Adalberto Luiz Rosa","doi":"10.2217/rme-2022-0219","DOIUrl":"https://doi.org/10.2217/rme-2022-0219","url":null,"abstract":"<p><p><b>Aim:</b> We evaluated the bone repair induced by MSCs from adipose tissue (AT-MSCs) and bone marrow (BM-MSCs) injected into rat calvarial defects at two time points. <b>Methods & results:</b> Both cell populations expressed MSC surface markers and differentiated into adipocytes and osteoblasts. μCT showed that the combination of cells from distinct sources exhibited synergistic effects to increase bone repair with an advantage when BM-MSCs were injected prior to AT-MSCs. The higher osteogenic potential of these MSC combinations was demonstrated using an <i>in vitro</i> coculture system where BM-MSCs and AT-MSCs association induced higher ALP activity in MC3T3-E1 cells. <b>Conclusion:</b> Our findings may drive new approaches to treat bone defects and shed light on the complexity of the mechanisms involved in bone regeneration.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9651363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Lateral epicondylitis: comparing ultrasound-guided tenotomy with or without amniotic membrane allograft injection. 外侧上髁炎:超声引导下的肌腱切开术与不注射同种异体羊膜的比较。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-05-01 DOI: 10.2217/rme-2023-0027
Hirotaka Nakagawa, Kyungje Sung, Ken Mautner, Tabitha May, Walter I Sussman
{"title":"Lateral epicondylitis: comparing ultrasound-guided tenotomy with or without amniotic membrane allograft injection.","authors":"Hirotaka Nakagawa,&nbsp;Kyungje Sung,&nbsp;Ken Mautner,&nbsp;Tabitha May,&nbsp;Walter I Sussman","doi":"10.2217/rme-2023-0027","DOIUrl":"https://doi.org/10.2217/rme-2023-0027","url":null,"abstract":"<p><p><b>Aim:</b> To evaluate the clinical response to augmenting ultrasound-guided tenotomy (USGT) with an amniotic membrane (AM) allograft injection. <b>Design:</b> Retrospective study. <b>Materials & methods:</b> Subjects underwent either a USGT (N = 16) or a combined USGT plus AM injection (N = 14). <b>Results:</b> Both groups demonstrated a significant reduction in pain from baseline starting after 2 weeks in the USGT plus AM group (p = 0.036) and after 8 weeks in the USGT group (p = 0.021). The reduction in pain was sustained for the entire duration of the study (52 weeks). There was no significant difference in pain levels at 26- or 52-week follow-up or patient satisfaction between the two groups. <b>Conclusion:</b> USGT with or without AM allograft injections results in a significant reduction in pain with high patient satisfaction.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9595728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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