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Perfusion in vivo bioreactor promotes regeneration of vascularized tissue-engineered bone. 体内生物反应器灌注促进血管化组织工程骨的再生。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0101
Peng Liu, Jian Wang, Yun Xue, Lei Zou, Yongzheng Tian, Ruilong Sun, Wenhua Zhang, Yunfei Li, Lijun Lv, Qiuming Gao, Bo Fan
{"title":"Perfusion <i>in vivo</i> bioreactor promotes regeneration of vascularized tissue-engineered bone.","authors":"Peng Liu,&nbsp;Jian Wang,&nbsp;Yun Xue,&nbsp;Lei Zou,&nbsp;Yongzheng Tian,&nbsp;Ruilong Sun,&nbsp;Wenhua Zhang,&nbsp;Yunfei Li,&nbsp;Lijun Lv,&nbsp;Qiuming Gao,&nbsp;Bo Fan","doi":"10.2217/rme-2023-0101","DOIUrl":"https://doi.org/10.2217/rme-2023-0101","url":null,"abstract":"<p><p><b>Aim:</b> This study improved the <i>in vivo</i> bioreactor (IVB) for bone regeneration by enhancing stem cell survival and promoting vascularized tissue-engineered bone. <b>Methods:</b> 12 New Zealand rabbits received β-TCP scaffolds with rabbit bone mesenchymal stem cells (BMSCs) implanted. Perfusion IVB with a perfusion electronic pump was compared with the control group using micro-CT, Microfil perfusion, histological staining and RT-PCR for gene expression. <b>Results:</b> Perfusion IVB demonstrated good biocompatibility, increased neoplastic bone tissue, neovascularization and upregulated osteogenic and angiogenesis-related genes in rabbits (p < 0.05). <b>Conclusion:</b> Perfusion IVB holds promise for bone regeneration and tissue engineering in orthopedics and maxillofacial surgery.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 9","pages":"707-718"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10219743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in May 2023. 2023年5月来自干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0111
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in May 2023.","authors":"Dusko Ilic,&nbsp;Mirjana Liovic","doi":"10.2217/rme-2023-0111","DOIUrl":"https://doi.org/10.2217/rme-2023-0111","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in May 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 9","pages":"681-694"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10498275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on 'Digital transformation of medical education: innovative pedagogy and regenerative surgery in the era of COVID-19'. 评论“医学教育的数字化转型:新冠肺炎时代的创新教学法和再生外科”。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0081
Evelyn Casilla-Huamán
{"title":"Comment on <i>'Digital transformation of medical education: innovative pedagogy and regenerative surgery in the era of COVID-19</i>'.","authors":"Evelyn Casilla-Huamán","doi":"10.2217/rme-2023-0081","DOIUrl":"https://doi.org/10.2217/rme-2023-0081","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 9","pages":"679-680"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10219740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current evidence on mesenchymal stem cells for hip osteoarthritis: a narrative review. 间充质干细胞治疗髋关节骨关节炎的最新证据:叙述性回顾。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0071
Mina Entessari, Leonardo P Oliveira
{"title":"Current evidence on mesenchymal stem cells for hip osteoarthritis: a narrative review.","authors":"Mina Entessari,&nbsp;Leonardo P Oliveira","doi":"10.2217/rme-2023-0071","DOIUrl":"https://doi.org/10.2217/rme-2023-0071","url":null,"abstract":"<p><p>There are limited data on the use of mesenchymal stem cell injections for hip osteoarthritis. The goal of this study was to evaluate the literature by analyzing outcomes and comparing methodologies. Online search of PubMed, SportsDiscus and Case Reports Keywords was completed using the keywords 'stem cells' and 'hip' and 'osteoarthritis'. Six studies met the inclusion and exclusion criteria. Five out the six studies had statistically significant improvement in patient reported outcomes after mesenchymal stem cell injections. Only two studies provided information on radiological changes and findings were positive. None of the studies reported major complications. Small series of non-randomized controlled trials completed to date in the use of mesenchymal stem cells for the treatment of hip osteoarthritis reported the procedures to be safe and provide a positive clinical response. Randomized controlled trials must be performed to further confirm mesenchymal stem cells as a treatment option for hip osteoarthritis.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 9","pages":"749-758"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10273075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of osteoarthritis severity, BMI and age on clinical efficacy of bone marrow aspirate concentrate in the treatment of knee osteoarthritis. 骨性关节炎严重程度、BMI及年龄对骨髓浓缩液治疗膝关节骨性关节炎临床疗效的影响
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0042
Predrag Rasovic, Oliver Dulic, Ivica Lalic, Radmila Matijevic, Natasa Janjic, Milan Tosic, Dejan Aleksandric, Dzihan Abazovic, Mladen Miskulin, Sara Matijevic, Luka Kovacevic
{"title":"The role of osteoarthritis severity, BMI and age on clinical efficacy of bone marrow aspirate concentrate in the treatment of knee osteoarthritis.","authors":"Predrag Rasovic,&nbsp;Oliver Dulic,&nbsp;Ivica Lalic,&nbsp;Radmila Matijevic,&nbsp;Natasa Janjic,&nbsp;Milan Tosic,&nbsp;Dejan Aleksandric,&nbsp;Dzihan Abazovic,&nbsp;Mladen Miskulin,&nbsp;Sara Matijevic,&nbsp;Luka Kovacevic","doi":"10.2217/rme-2023-0042","DOIUrl":"https://doi.org/10.2217/rme-2023-0042","url":null,"abstract":"<p><p><b>Aim:</b> The aim of this study was to assess whether BMI, severity of knee osteoarthritis, age and gender have any influence on the final clinical results of bone marrow aspirate concentrate injection. <b>Method:</b> A total of 111 study participants with painful knee osteoarthritis and different characteristics concerning before mentioned factors underwent bone marrow aspirate concentrate (BMAC) therapy and were followed up for 1 year. <b>Result:</b> Significant pain and functional improvement were observed in all participant groups. Participants' age and BMI did not influence the clinical outcome, but there was an influence of OA severity, especially among older patients. <b>Conclusion:</b> This study shows that BMAC therapy is effective. Younger patients with milder OA changes could be better candidates for long-lasting and more efficient BMAC therapy. <b>Clinical Trial Registration:</b> NCT03825133 (ClinicalTrials.gov).</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 9","pages":"735-747"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10273545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in April 2023. 2023年4月来自干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-08-01 DOI: 10.2217/rme-2023-0105
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in April 2023.","authors":"Dusko Ilic,&nbsp;Mirjana Liovic","doi":"10.2217/rme-2023-0105","DOIUrl":"https://doi.org/10.2217/rme-2023-0105","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in April 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 8","pages":"591-599"},"PeriodicalIF":2.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9970929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The regulatory challenge of 3D bioprinting. 3D生物打印的监管挑战。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-08-01 DOI: 10.2217/rme-2022-0194
Tajanka Mladenovska, Peter F Choong, Gordon G Wallace, Cathal D O'Connell
{"title":"The regulatory challenge of 3D bioprinting.","authors":"Tajanka Mladenovska,&nbsp;Peter F Choong,&nbsp;Gordon G Wallace,&nbsp;Cathal D O'Connell","doi":"10.2217/rme-2022-0194","DOIUrl":"https://doi.org/10.2217/rme-2022-0194","url":null,"abstract":"<p><p>New developments in additive manufacturing and regenerative medicine have the potential to radically disrupt the traditional pipelines of therapy development and medical device manufacture. These technologies present a challenge for regulators because traditional regulatory frameworks are designed for mass manufactured therapies, rather than bespoke solutions. 3D bioprinting technologies present another dimension of complexity through the inclusion of living cells in the fabrication process. Herein we overview the challenge of regulating 3D bioprinting in comparison to existing cell therapy products as well as custom-made 3D printed medical devices. We consider a range of specific challenges pertaining to 3D bioprinting in regenerative medicine, including classification, risk, standardization and quality control, as well as technical issues related to the manufacturing process and the incorporated materials and cells.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 8","pages":"659-674"},"PeriodicalIF":2.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9961524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The role of probiotics in tissue engineering and regenerative medicine. 益生菌在组织工程和再生医学中的作用。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-08-01 Epub Date: 2023-07-26 DOI: 10.2217/rme-2022-0209
Ali Golchin, Parviz Ranjbarvan, Shima Parviz, Amene Shokati, Roya Naderi, Yousef Rasmi, Samaneh Kiani, Faezeh Moradi, Fahimeh Heidari, Zohreh Saltanatpour, Akram Alizadeh
{"title":"The role of probiotics in tissue engineering and regenerative medicine.","authors":"Ali Golchin, Parviz Ranjbarvan, Shima Parviz, Amene Shokati, Roya Naderi, Yousef Rasmi, Samaneh Kiani, Faezeh Moradi, Fahimeh Heidari, Zohreh Saltanatpour, Akram Alizadeh","doi":"10.2217/rme-2022-0209","DOIUrl":"10.2217/rme-2022-0209","url":null,"abstract":"<p><p>Tissue engineering and regenerative medicine (TERM) as an emerging field is a multidisciplinary science and combines basic sciences such as biomaterials science, biology, genetics and medical sciences to achieve functional TERM-based products to regenerate or replace damaged or diseased tissues or organs. Probiotics are useful microorganisms which have multiple effective functions on human health. They have some immunomodulatory and biocompatibility effects and improve wound healing. In this article, we describe the latest findings on probiotics and their pro-healing properties on various body systems that are useable in regenerative medicine. Therefore, this review presents a new perspective on the therapeutic potential of probiotics for TERM.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 8","pages":"635-657"},"PeriodicalIF":2.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10324832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative analysis of rule elements for transportation of cell therapy products among regulations and standards. 细胞治疗产品运输法规和标准的规则要素比较分析。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-08-01 Epub Date: 2023-06-21 DOI: 10.2217/rme-2022-0215
Yoshihiko Okamura, Shingo Kano
{"title":"Comparative analysis of rule elements for transportation of cell therapy products among regulations and standards.","authors":"Yoshihiko Okamura, Shingo Kano","doi":"10.2217/rme-2022-0215","DOIUrl":"10.2217/rme-2022-0215","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to identify the elements involved in the transportation of cell therapy products by conducting a comparative analysis of four related international standards for temperature-controlled delivery and good distribution practice (GDP). <b>Methods:</b> An analytical framework was constructed to cover the entire transportation process. The descriptions of each element in the Pharmaceutical Inspection Convention and Pharmaceutical Inspection Co-operation Scheme (PIC/S) GDP, International Organization for Standardization (ISO) 21973, Foundation for the Accreditation of Cellular Therapy Common Standards for Cellular Therapies and ISO 23412 were compared. <b>Results:</b> The study identified some elements that were present in the PIC/S GDP and other standards but were absent in ISO 21973, and <i>vice versa</i>. These elements are crucial in view of the increasing opportunities to transport allogeneic cells in the future. <b>Conclusion:</b> The study identified the necessary elements that should be included in the development of transport regulations for cell therapy products.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 8","pages":"611-622"},"PeriodicalIF":2.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9970928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of platelet-rich plasma on healing of autologous graft after anterior cruciate ligament reconstruction: a randomized control trial. 富血小板血浆对前交叉韧带重建后自体移植物愈合的影响:一项随机对照试验。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-08-01 DOI: 10.2217/rme-2023-0108
Kishor Munde, Sumit Banerjee, Nitesh Gahlot, Abhay Elhence, Saptarshi Mandal, Taruna Yadav
{"title":"Effect of platelet-rich plasma on healing of autologous graft after anterior cruciate ligament reconstruction: a randomized control trial.","authors":"Kishor Munde,&nbsp;Sumit Banerjee,&nbsp;Nitesh Gahlot,&nbsp;Abhay Elhence,&nbsp;Saptarshi Mandal,&nbsp;Taruna Yadav","doi":"10.2217/rme-2023-0108","DOIUrl":"https://doi.org/10.2217/rme-2023-0108","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to assess the effect of platelet-rich plasma (PRP) on anterior cruciate ligament (ACL) graft healing at graft tunnel interface and ACL graft 6 months post-reconstruction. <b>Material & methods:</b> A randomized trial involving 87 patients was conducted, dividing them into PRP and non-PRP groups. Magnetic resonance imaging (MRI) and functional outcome measures were used to evaluate graft healing. <b>Results:</b> Out of the 87 patients, 80 were analyzed. The PRP group exhibited superior clinical and radiological outcomes compared with the non-PRP group, as indicated by Figueroas score, Lysholm score and knee range of motion. <b>Conclusion:</b> These findings demonstrate that PRP can be used as an adjunct therapy for ACL reconstruction, enhancing graft healing and improving patient outcomes. CTRI approval (Reg. No - CTRI/2018/11/016263).</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 8","pages":"601-610"},"PeriodicalIF":2.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10324831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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