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Industry updates from the field of stem cell research and regenerative medicine in April 2023. 2023年4月来自干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-08-01 DOI: 10.2217/rme-2023-0105
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in April 2023.","authors":"Dusko Ilic,&nbsp;Mirjana Liovic","doi":"10.2217/rme-2023-0105","DOIUrl":"https://doi.org/10.2217/rme-2023-0105","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in April 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9970929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The regulatory challenge of 3D bioprinting. 3D生物打印的监管挑战。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-08-01 DOI: 10.2217/rme-2022-0194
Tajanka Mladenovska, Peter F Choong, Gordon G Wallace, Cathal D O'Connell
{"title":"The regulatory challenge of 3D bioprinting.","authors":"Tajanka Mladenovska,&nbsp;Peter F Choong,&nbsp;Gordon G Wallace,&nbsp;Cathal D O'Connell","doi":"10.2217/rme-2022-0194","DOIUrl":"https://doi.org/10.2217/rme-2022-0194","url":null,"abstract":"<p><p>New developments in additive manufacturing and regenerative medicine have the potential to radically disrupt the traditional pipelines of therapy development and medical device manufacture. These technologies present a challenge for regulators because traditional regulatory frameworks are designed for mass manufactured therapies, rather than bespoke solutions. 3D bioprinting technologies present another dimension of complexity through the inclusion of living cells in the fabrication process. Herein we overview the challenge of regulating 3D bioprinting in comparison to existing cell therapy products as well as custom-made 3D printed medical devices. We consider a range of specific challenges pertaining to 3D bioprinting in regenerative medicine, including classification, risk, standardization and quality control, as well as technical issues related to the manufacturing process and the incorporated materials and cells.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9961524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Comparative analysis of rule elements for transportation of cell therapy products among regulations and standards. 细胞治疗产品运输法规和标准的规则要素比较分析。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-08-01 Epub Date: 2023-06-21 DOI: 10.2217/rme-2022-0215
Yoshihiko Okamura, Shingo Kano
{"title":"Comparative analysis of rule elements for transportation of cell therapy products among regulations and standards.","authors":"Yoshihiko Okamura, Shingo Kano","doi":"10.2217/rme-2022-0215","DOIUrl":"10.2217/rme-2022-0215","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to identify the elements involved in the transportation of cell therapy products by conducting a comparative analysis of four related international standards for temperature-controlled delivery and good distribution practice (GDP). <b>Methods:</b> An analytical framework was constructed to cover the entire transportation process. The descriptions of each element in the Pharmaceutical Inspection Convention and Pharmaceutical Inspection Co-operation Scheme (PIC/S) GDP, International Organization for Standardization (ISO) 21973, Foundation for the Accreditation of Cellular Therapy Common Standards for Cellular Therapies and ISO 23412 were compared. <b>Results:</b> The study identified some elements that were present in the PIC/S GDP and other standards but were absent in ISO 21973, and <i>vice versa</i>. These elements are crucial in view of the increasing opportunities to transport allogeneic cells in the future. <b>Conclusion:</b> The study identified the necessary elements that should be included in the development of transport regulations for cell therapy products.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9970928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of probiotics in tissue engineering and regenerative medicine. 益生菌在组织工程和再生医学中的作用。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-08-01 Epub Date: 2023-07-26 DOI: 10.2217/rme-2022-0209
Ali Golchin, Parviz Ranjbarvan, Shima Parviz, Amene Shokati, Roya Naderi, Yousef Rasmi, Samaneh Kiani, Faezeh Moradi, Fahimeh Heidari, Zohreh Saltanatpour, Akram Alizadeh
{"title":"The role of probiotics in tissue engineering and regenerative medicine.","authors":"Ali Golchin, Parviz Ranjbarvan, Shima Parviz, Amene Shokati, Roya Naderi, Yousef Rasmi, Samaneh Kiani, Faezeh Moradi, Fahimeh Heidari, Zohreh Saltanatpour, Akram Alizadeh","doi":"10.2217/rme-2022-0209","DOIUrl":"10.2217/rme-2022-0209","url":null,"abstract":"<p><p>Tissue engineering and regenerative medicine (TERM) as an emerging field is a multidisciplinary science and combines basic sciences such as biomaterials science, biology, genetics and medical sciences to achieve functional TERM-based products to regenerate or replace damaged or diseased tissues or organs. Probiotics are useful microorganisms which have multiple effective functions on human health. They have some immunomodulatory and biocompatibility effects and improve wound healing. In this article, we describe the latest findings on probiotics and their pro-healing properties on various body systems that are useable in regenerative medicine. Therefore, this review presents a new perspective on the therapeutic potential of probiotics for TERM.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10324832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acellular collagen-glycosaminoglycan matrix promotes functional recovery in a rat model of volumetric muscle loss. 脱细胞胶原-糖胺聚糖基质促进大鼠体积性肌肉损失模型的功能恢复。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-08-01 DOI: 10.2217/rme-2023-0060
Christina Zhu, Mehran Karvar, Daniel J Koh, Karina Sklyar, Yori Endo, Jacob Quint, Mohamadmahdi Samandari, Ali Tamayol, Indranil Sinha
{"title":"Acellular collagen-glycosaminoglycan matrix promotes functional recovery in a rat model of volumetric muscle loss.","authors":"Christina Zhu,&nbsp;Mehran Karvar,&nbsp;Daniel J Koh,&nbsp;Karina Sklyar,&nbsp;Yori Endo,&nbsp;Jacob Quint,&nbsp;Mohamadmahdi Samandari,&nbsp;Ali Tamayol,&nbsp;Indranil Sinha","doi":"10.2217/rme-2023-0060","DOIUrl":"https://doi.org/10.2217/rme-2023-0060","url":null,"abstract":"<p><p><b>Aim:</b> Volumetric muscle loss (VML) is a composite loss of skeletal muscle, which heals with fibrosis, minimal muscle regeneration, and incomplete functional recovery. This study investigated whether collagen-glycosaminoglycan scaffolds (CGS) improve functional recovery following VML. <b>Methods:</b> 15 Sprague-Dawley rats underwent either sham injury or bilateral tibialis anterior (TA) VML injury, with or without CGS implantation. <b>Results:</b> In rats with VML injuries treated with CGS, the TA exhibited greater <i>in vivo</i> tetanic forces and <i>in situ</i> twitch and tetanic dorsiflexion forces compared with those in the non-CGS group at 4- and 6-weeks following injury, respectively. Histologically, the VML with CGS group demonstrated reduced fibrosis and increased muscle regeneration. <b>Conclusion:</b> Taken together, CGS implantation has potential augment muscle recovery following VML.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10324833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effect of platelet-rich plasma on healing of autologous graft after anterior cruciate ligament reconstruction: a randomized control trial. 富血小板血浆对前交叉韧带重建后自体移植物愈合的影响:一项随机对照试验。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-08-01 DOI: 10.2217/rme-2023-0108
Kishor Munde, Sumit Banerjee, Nitesh Gahlot, Abhay Elhence, Saptarshi Mandal, Taruna Yadav
{"title":"Effect of platelet-rich plasma on healing of autologous graft after anterior cruciate ligament reconstruction: a randomized control trial.","authors":"Kishor Munde,&nbsp;Sumit Banerjee,&nbsp;Nitesh Gahlot,&nbsp;Abhay Elhence,&nbsp;Saptarshi Mandal,&nbsp;Taruna Yadav","doi":"10.2217/rme-2023-0108","DOIUrl":"https://doi.org/10.2217/rme-2023-0108","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to assess the effect of platelet-rich plasma (PRP) on anterior cruciate ligament (ACL) graft healing at graft tunnel interface and ACL graft 6 months post-reconstruction. <b>Material & methods:</b> A randomized trial involving 87 patients was conducted, dividing them into PRP and non-PRP groups. Magnetic resonance imaging (MRI) and functional outcome measures were used to evaluate graft healing. <b>Results:</b> Out of the 87 patients, 80 were analyzed. The PRP group exhibited superior clinical and radiological outcomes compared with the non-PRP group, as indicated by Figueroas score, Lysholm score and knee range of motion. <b>Conclusion:</b> These findings demonstrate that PRP can be used as an adjunct therapy for ACL reconstruction, enhancing graft healing and improving patient outcomes. CTRI approval (Reg. No - CTRI/2018/11/016263).</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10324831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
miR-125b-5p alleviates the damage of myocardial infarction by inhibiting the NFAT2 to reduce F2RL2 expression. miR-125b-5p通过抑制NFAT2，降低F2RL2的表达，减轻心肌梗死的损害。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-07-01 DOI: 10.2217/rme-2022-0150
Zhenhua Wu, Jie Geng, Yunpeng Bai, Yujuan Qi, Chao Chang, Yan Jiao, Zhigang Guo
{"title":"miR-125b-5p alleviates the damage of myocardial infarction by inhibiting the <i>NFAT2</i> to reduce <i>F2RL2</i> expression.","authors":"Zhenhua Wu,&nbsp;Jie Geng,&nbsp;Yunpeng Bai,&nbsp;Yujuan Qi,&nbsp;Chao Chang,&nbsp;Yan Jiao,&nbsp;Zhigang Guo","doi":"10.2217/rme-2022-0150","DOIUrl":"https://doi.org/10.2217/rme-2022-0150","url":null,"abstract":"<p><p><b>Aim:</b> To explore the effect of miR-125b-5p/nuclear factor of activated T cells 1 (<i>NFAT2</i>)/<i>F2RL2</i> on myocardial infarction (MI). <b>Method:</b> After establishment of MI mouse model and oxygen glucose deprivation (OGD)-induced cell model, the effects of <i>NFAT2</i> on the process of MI were observed, the effects of miR-125b-5p/<i>NFAT2</i>/<i>F2RL2</i> on the cell viability, apoptosis, and inflammatory factors levels were determined. <b>Result:</b> <i>NFAT2</i> silencing relieved MI and inhibited the inflammation in MI model mice. In OGD-induced human coronary artery endothelial cells and human cardiac microvascular endothelial cells, miR-125b-5p enhanced cell viability, yet repressed cell apoptosis and inflammatory factors and NFAT2 levels. NFAT2 overexpression reversed the effects of miR-125b-5p, while <i>F2RL2</i> silencing offset the effects of NFAT2 overexpression. <b>Conclusion:</b> MiR-125b-5p alleviates MI injury by inhibiting <i>NFAT2</i> level to reduce <i>F2RL2</i> expression.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10112394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in March 2023. 2023年3月来自干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-07-01 DOI: 10.2217/rme-2023-0067
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in March 2023.","authors":"Dusko Ilic,&nbsp;Mirjana Liovic","doi":"10.2217/rme-2023-0067","DOIUrl":"https://doi.org/10.2217/rme-2023-0067","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in March 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9689153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How proven is a 'proven intervention'? Ethics of placebo controls in light of conditional approval programs. “经过验证的干预措施”有多成熟?根据有条件批准程序，安慰剂控制的伦理学。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-07-01 Epub Date: 2023-06-21 DOI: 10.2217/rme-2022-0021
Kristina Hug
{"title":"How proven is a 'proven intervention'? Ethics of placebo controls in light of conditional approval programs.","authors":"Kristina Hug","doi":"10.2217/rme-2022-0021","DOIUrl":"10.2217/rme-2022-0021","url":null,"abstract":"<p><p>This article discusses the difficulties of establishing whether there exists a proven therapeutic intervention when regenerative experimental treatments are made accessible to patients under conditional approval programs (outside clinical trials). Conditional approvals are often made on the basis of less robust efficacy evidence than otherwise required for the registration of new treatments. Lower quality of evidence affects the ethical justification of using a placebo-control design. The absence of a proven intervention is important in evaluating whether it is ethically justifiable to use such a design in a clinical trial and is present in major ethical guidelines. The main argument in this paper is that conditionally approved therapies, if referred to as 'proven interventions', would make placebo-control design ethically unjustifiable. Conducting rigorous clinical trials after conditional approvals is crucial to establish the efficacy of therapeutic approaches under such approvals. Hindrances to running such trials and generating further efficacy evidence are brought to attention.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9697342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of decellularization using sodium dodecyl sulfate on glycosaminoglycans content in the liver. 十二烷基硫酸钠脱细胞对肝脏中糖胺聚糖含量的影响。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-07-01 DOI: 10.2217/rme-2023-0050
Meghana Kasturi, Kirthanashri S Vasanthan
{"title":"Effect of decellularization using sodium dodecyl sulfate on glycosaminoglycans content in the liver.","authors":"Meghana Kasturi,&nbsp;Kirthanashri S Vasanthan","doi":"10.2217/rme-2023-0050","DOIUrl":"https://doi.org/10.2217/rme-2023-0050","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9726929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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