Regenerative medicine最新文献_第8页

The effects of polynucleotides-based biomimetic hydrogels in tissue repair: a 2D and 3D in vitro study. 基于多核苷酸的仿生水凝胶在组织修复中的作用：2D和3D体外研究。

IF 3 4区医学

Regenerative medicine Pub Date : 2025-09-01 Epub Date: 2025-09-29 DOI: 10.1080/17460751.2025.2567177

Maria Teresa Colangelo, Stefano Guizzardi, Luana Laschera, Marco Meleti, Carlo Galli

{"title":"The effects of polynucleotides-based biomimetic hydrogels in tissue repair: a 2D and 3D in vitro study.","authors":"Maria Teresa Colangelo, Stefano Guizzardi, Luana Laschera, Marco Meleti, Carlo Galli","doi":"10.1080/17460751.2025.2567177","DOIUrl":"10.1080/17460751.2025.2567177","url":null,"abstract":"Introduction: Biomimetics offers promising tools to improve wound healing in difficult clinical conditions. Polynucleotides (PN) show high potential for tissue repair in oral and periodontal surgery, by relying on the body's inherent self-healing capabilities. The aim of the present study was to elucidate in vitro the effects of Odonto-PN (O-PN) and Regenfast (REG), two PN-based compounds, on oral tissue repair.Methods: We employed 3D spheroid cultures and cell scratch assays to simulate wound healing in vitro, assessing cell migration and morphology under normal conditions and following mitomycin-induced inhibition of cell growth.Results: Both O-PN and REG supported early cell viability and spheroid disassembly. O-PN supported the initial outgrowth of fibroblasts, whereas REG enhanced sustained cell migration at later time points. In scratch assays, REG effectively facilitated defect closure - even under mitomycin treatment - and induced a more elongated, migratory cell phenotype.Conclusions: These findings suggest that both O-PN and REG can favorably modulate fibroblast function to support wound repair. While O-PN fosters early activation and cell viability, REG exerts potent pro-migratory effects that may be particularly useful for complex periodontal regeneration. Their selective use could provide valuable adjuncts in clinical protocols aimed at restoring delicate oral structures, such as the interdental papillae.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"365-373"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Industry updates from the field of stem cell research and regenerative medicine in May 2025. 2025年5月来自干细胞研究和再生医学领域的行业更新。

IF 3 4区医学

Regenerative medicine Pub Date : 2025-09-01 Epub Date: 2025-06-29 DOI: 10.1080/17460751.2025.2525719

Dusko Ilic, Mirjana Liovic

引用次数: 0

Building the framework for bioprinted human heart tissue: recent developments and future prospects. 构建生物打印人类心脏组织的框架：最近的发展和未来前景。

IF 3 4区医学

Regenerative medicine Pub Date : 2025-09-01 Epub Date: 2025-09-11 DOI: 10.1080/17460751.2025.2558269

Victor A da Silva, Man Chi Leung, McGregor Clayton, Leya Oommen, Hannia Madrigal, Zachary Laksman, Bosco Yu, Stephanie M Willerth

引用次数: 0

LGBTQ+ persons, queer bioethics, and inclusivity in stem cell research and regenerative medicine. LGBTQ+人群，酷儿生物伦理，以及干细胞研究和再生医学的包容性。

IF 3 4区医学

Regenerative medicine Pub Date : 2025-09-01 Epub Date: 2025-09-22 DOI: 10.1080/17460751.2025.2561461

Sydney E Prange, Leigh Turner

{"title":"LGBTQ+ persons, queer bioethics, and inclusivity in stem cell research and regenerative medicine.","authors":"Sydney E Prange, Leigh Turner","doi":"10.1080/17460751.2025.2561461","DOIUrl":"10.1080/17460751.2025.2561461","url":null,"abstract":"Despite the increasing visibility of the LGBTQ+ (Lesbian, Gay, Bisexual, Transgender, Queer, and other expansive genders or sexual orientations) community, LGBTQ+ persons continue to face significant barriers, discrimination, and stigmatization in the health care space. The unique challenges faced by LGBTQ+ persons in healthcare led bioethicists to develop queer bioethics. This approach to ethical reflection suggests that we should develop understanding of biomedical and biological topics related to LGBTQ+ persons and that we should examine topics not traditionally associated with LGBTQ+ persons through a queer lens. Here, we argue that queer bioethics provides valuable new perspectives for improving stem cell science. We examine specific issues that should be examined using a queer bioethical framework for the benefit of all persons and the overall advancement of stem cell science. We specifically address strategies for stem cell donation recruitment, creation of more comprehensive stem cell models for precision medicine, and the promotion of more inclusive practices for LGBTQ+ persons in the stem cell science workforce. We contend that these important and timely topics provide suitable starting points for applying a queer bioethical perspective to stem cell research and regenerative medicine. Furthermore, we underscore the importance of addressing these topics in the current political climate.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"387-397"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stem cell-derived extracellular vesicles as a therapeutic for avascular necrosis: current status and future prospects. 干细胞来源的细胞外囊泡治疗缺血性坏死：现状和未来前景。

IF 3 4区医学

Regenerative medicine Pub Date : 2025-09-01 Epub Date: 2025-09-23 DOI: 10.1080/17460751.2025.2561454

Vaijayanti Kale

{"title":"Stem cell-derived extracellular vesicles as a therapeutic for avascular necrosis: current status and future prospects.","authors":"Vaijayanti Kale","doi":"10.1080/17460751.2025.2561454","DOIUrl":"10.1080/17460751.2025.2561454","url":null,"abstract":"Avascular necrosis (AVN), also referred to as osteonecrosis (ON), is a major clinical challenge in orthopedic practice. Current treatment strategies include surgical options such as core decompression, as well as non-surgical approaches including statin therapy, weight reduction, and physiotherapy. Regenerative therapies - such as platelet-rich plasma injections, autologous bone marrow cell concentrates, and mesenchymal stem/stromal cells (MSCs), among others have shown some success. Although induced pluripotent stem cells (iPSCs) represent a promising source for cell therapy, their clinical application is restricted due to the risk of teratoma formation. In this context, the therapeutic potential of extracellular vesicles (EVs) secreted by stem cells has emerged as a relatively new area of investigation. This review summarizes findings from preclinical studies in animal models that have explored the use of MSC- and iPSC-derived EVs in the regenerative treatment of AVN/ON. Compared with MSC-EVs, the therapeutic use of iPSC-EVs has progressed more slowly, partly due to the high cost of expanding iPSCs to obtain a sufficient quantity of their EVs. Therefore, instead of using iPSC-derived EVs, the use of a cocktail of EVs secreted by iPSC-derived cellular derivatives may represent a safer, more cost-effective, and potentially more efficacious strategy for treating AVN.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"399-408"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Industry updates from the field of stem cell research and regenerative medicine in July 2025. 2025年7月来自干细胞研究和再生医学领域的行业更新。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2025-08-30 DOI: 10.1080/17460751.2025.2551422

Dusko Ilic, Mirjana Liovic

引用次数: 0

Sustained long-term benefits of autologous subconjunctival platelet-rich plasma injections for severe dry eye disease. 自体结膜下富血小板血浆注射治疗严重干眼病的持续长期疗效

IF 3 4区医学

Regenerative medicine Pub Date : 2025-08-01 Epub Date: 2025-08-07 DOI: 10.1080/17460751.2025.2544486

Amparo M Mora, Carlos M Córdoba, Mario A Jimenez-Mora, Fabio Daniel Padilla-Pantoja

{"title":"Sustained long-term benefits of autologous subconjunctival platelet-rich plasma injections for severe dry eye disease.","authors":"Amparo M Mora, Carlos M Córdoba, Mario A Jimenez-Mora, Fabio Daniel Padilla-Pantoja","doi":"10.1080/17460751.2025.2544486","DOIUrl":"10.1080/17460751.2025.2544486","url":null,"abstract":"Dry eye disease (DED) is a multifactorial condition that significantly impairs patients' quality of life, particularly in its severe forms, which are often unresponsive to conventional therapies. In this retrospective study, we evaluated the long-term efficacy and safety of subconjunctival platelet-rich plasma (PRP) injections in six Hispanic women with refractory DED. A total of eleven eyes were treated with a standardized protocol consisting of five PRP injections - three administered monthly, followed by two spaced two months apart - and followed for a period of 12 months. Clinical assessments included both subjective and objective measures, such as the Ocular Surface Disease Index (OSDI), Schirmer test, tear breakup time (BUT), and ocular surface staining with fluorescein and lissamine green. Significant and sustained improvements were observed across all parameters throughout the follow-up period, and no serious adverse events were reported. Notably, this is the first study to demonstrate that subconjunctival PRP injections may provide long-term symptomatic relief in patients with refractory DED. These findings suggest that this novel, well-tolerated, and accessible therapeutic approach may represent a promising alternative for individuals who do not respond to conventional treatments and warrant further investigation in larger populations.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"331-338"},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12407845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Industry updates from the field of stem cell research and regenerative medicine in April 2025. 2025年4月来自干细胞研究和再生医学领域的行业更新。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2025-08-01 Epub Date: 2025-06-06 DOI: 10.1080/17460751.2025.2514908

Dusko Ilic, Mirjana Liovic

引用次数: 0

Optimizing methods for regenerative endodontics. 再生牙髓学的优化方法。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2025-08-01 Epub Date: 2025-09-01 DOI: 10.1080/17460751.2025.2546759

Alexandre Henrique Dos Reis-Prado, Francine Benetti, Marco C Bottino, Renan Dal-Fabbro

引用次数: 0

Biological tendon regeneration, are we almost there or is it still a stretch? 生物肌腱再生，我们快实现了吗，还是还有很长的路要走？

IF 3 4区医学

Regenerative medicine Pub Date : 2025-08-01 Epub Date: 2025-08-13 DOI: 10.1080/17460751.2025.2546758

Ahmet Engin Pazarceviren, Minoo Bastani, Dmitriy Sheyn

引用次数: 0