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Therapeutic potential of adipose tissue derivatives in skin photoaging. 脂肪组织衍生物在皮肤光老化中的治疗潜力。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-11-01 Epub Date: 2023-09-25 DOI: 10.2217/rme-2023-0098
Meiqi Liu, Feng Lu, Jingwei Feng
{"title":"Therapeutic potential of adipose tissue derivatives in skin photoaging.","authors":"Meiqi Liu, Feng Lu, Jingwei Feng","doi":"10.2217/rme-2023-0098","DOIUrl":"10.2217/rme-2023-0098","url":null,"abstract":"<p><p>Photoaging, the primary cause of exogenous skin aging and predominantly caused by ultraviolet radiation, is an essential type of skin aging characterized by chronic skin inflammation. Recent studies have shown that oxidative stress, inflammation, skin barrier homeostasis, collagen denaturation and pigmentation are the main contributors to it. As a composite tissue rich in matrix and vascular components, adipose tissue derivatives have been recently gaining attention as potential therapeutic agents for various human diseases with fat-processing technology upgrades. This review analyzes both 'minimally treated' and 'nonminimally treated' fat derivatives to give an overview of the preclinical and clinical relevance of adipose tissue derivatives for antiphotoaging application, highlighting their good clinical prospects as well as discussing their safety and potential risks.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"869-883"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41169703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secretome profile of TNF-α-induced human umbilical cord mesenchymal stem cells unveils biological processes relevant to skin wound healing. TNF-α-诱导的人脐带间充质干细胞分泌组谱揭示了与皮肤伤口愈合相关的生物学过程。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-11-01 Epub Date: 2023-09-06 DOI: 10.2217/rme-2023-0085
Lihui Tai, Nik Syazana Saffery, Sze Piaw Chin, Soon Keng Cheong
{"title":"Secretome profile of TNF-α-induced human umbilical cord mesenchymal stem cells unveils biological processes relevant to skin wound healing.","authors":"Lihui Tai, Nik Syazana Saffery, Sze Piaw Chin, Soon Keng Cheong","doi":"10.2217/rme-2023-0085","DOIUrl":"10.2217/rme-2023-0085","url":null,"abstract":"<p><p><b>Aim:</b> To profile and study the proteins responsible for the beneficial effect of the TNF-α-induced human umbilical cord mesenchymal stem cells (hUCMSCs) secretome in wound healing. <b>Methods:</b> The hUCMSCs secretome was generated with (induced) or without (uninduced) TNF-α and was subsequently analyzed by liquid chromatography-mass spectrometry, immunoassay and <i>in vitro</i> scratch assay. <b>Results:</b> Proteomic analysis revealed approximately 260 proteins, including 51 and 55 unique proteins in the induced and uninduced secretomes, respectively. Gene ontology analysis disclosed that differential proteins in the induced secretome mainly involved inflammation-related terms. The induced secretome, consisting of higher levels of FGFb, VEGF, PDGF and IL-6, significantly accelerated wound closure and enhanced MMP-13 secretion in HaCaT keratinocytes. <b>Conclusion:</b> The secretome from induced hUCMSCs includes factors that promote wound closure.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"839-856"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10516222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microfragmented adipose tissue in the treatment of a full-thickness supraspinatus tear: a case report. 微碎脂肪组织治疗全层冈上肌撕裂：一例报告。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-10-01 Epub Date: 2023-09-20 DOI: 10.2217/rme-2023-0086
John L Ferrell, Alanna Dodson, Joshua Martin
{"title":"Microfragmented adipose tissue in the treatment of a full-thickness supraspinatus tear: a case report.","authors":"John L Ferrell,&nbsp;Alanna Dodson,&nbsp;Joshua Martin","doi":"10.2217/rme-2023-0086","DOIUrl":"https://doi.org/10.2217/rme-2023-0086","url":null,"abstract":"<p><p>A 70-year-old female presented with an 8-month history of right anterior shoulder pain and weakness, unresolved with conservative management. Among other shoulder pathology, the patient was diagnosed with a full-thickness supraspinatus tear and elected to proceed with the microfragmented adipose tissue procedure to treat the injured tendon and nearby relevant structures. Improvements in pain and function were documented along with progressive healing of the supraspinatus on ultrasound and MRI following the procedure. This case demonstrates the efficacy of microfragmented adipose tissue as a relatively novel approach to treating non-retracted, full-thickness rotator cuff tears.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 10","pages":"773-780"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and efficacy claims made by US businesses marketing purported stem cell treatments and exosome therapies. 营销所谓干细胞治疗和外泌体治疗的美国企业提出的安全性和有效性声明。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-10-01 Epub Date: 2023-10-05 DOI: 10.2217/rme-2023-0118
Leigh Turner, Juan Ramon Martinez, Shemms Najjar, Thevin Rajapaksha Arachchilage, Victoria Sahrai, Jia Chieng Wang
{"title":"Safety and efficacy claims made by US businesses marketing purported stem cell treatments and exosome therapies.","authors":"Leigh Turner, Juan Ramon Martinez, Shemms Najjar, Thevin Rajapaksha Arachchilage, Victoria Sahrai, Jia Chieng Wang","doi":"10.2217/rme-2023-0118","DOIUrl":"10.2217/rme-2023-0118","url":null,"abstract":"<p><p><b>Aim:</b> Examining websites of US businesses engaged in direct-to-consumer advertising of putative stem cell treatments and exosome therapies, this study investigated the marketing claims such companies make about the purported safety and efficacy of these products. <b>Methods:</b> Data mining and content analysis of company websites were used to identify and analyze safety and efficacy claims. <b>Results:</b> Of the 978 businesses analyzed, less than half the companies made identifiable claims about the safety and efficacy of their advertised stem cell and exosome products. We also explored how companies framed the stem cell and exosome products they promoted. Representations ranged from assertions that such products are unproven and investigational to claims they constituted cures. Most advertising frames fell between these poles. <b>Conclusion:</b> Some businesses include in their marketing representations claims about the safety and efficacy of advertised products. Businesses that did not make such assertions use other techniques to attract prospective clients.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 10","pages":"781-793"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41152502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From fetal tendon regeneration to adult therapeutic modalities: TGF-β3 in scarless healing. 从胎儿肌腱再生到成人治疗模式：TGF-β3在无瘢痕愈合中的作用。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-10-01 Epub Date: 2023-09-06 DOI: 10.2217/rme-2023-0145
Hanyue Li, Shengyu Luo, Hongtao Li, Hongyu Pan, Li Jiang, Yixuan Chen, Hui Chen, Zhenhua Feng, Sen Li
{"title":"From fetal tendon regeneration to adult therapeutic modalities: TGF-β3 in scarless healing.","authors":"Hanyue Li,&nbsp;Shengyu Luo,&nbsp;Hongtao Li,&nbsp;Hongyu Pan,&nbsp;Li Jiang,&nbsp;Yixuan Chen,&nbsp;Hui Chen,&nbsp;Zhenhua Feng,&nbsp;Sen Li","doi":"10.2217/rme-2023-0145","DOIUrl":"10.2217/rme-2023-0145","url":null,"abstract":"<p><p>Tendon injuries are common disorders that can significantly impact people's lives. Unfortunately, the limited regenerative ability of tendons results in tissue healing in a scar-mediated manner. The current therapeutic strategies fail to fully recover the functions of the injured tendons, and as such, the conception of 'scarless healing' has gained prominent attention in the field of regenerative medicine. Interestingly, injured fetal tendons possess the capability to heal through regeneration, which builds an ideal blueprint for adult tendon regeneration. Studies have shown that fetal biochemical cues have the potential to improve adult tendon healing. Here we review the biological factors that contribute to fetal tendon regeneration and how manipulation of these biochemical cues in the adult tendon healing process could achieve regeneration.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"809-822"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10163308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in June 2023. 2023年6月，干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-10-01 Epub Date: 2023-08-09 DOI: 10.2217/rme-2023-0152
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in June 2023.","authors":"Dusko Ilic,&nbsp;Mirjana Liovic","doi":"10.2217/rme-2023-0152","DOIUrl":"10.2217/rme-2023-0152","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in June 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"759-772"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9959912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential of mesenchymal stem cell-derived conditioned medium/secretome as a therapeutic option for ocular diseases. 间充质干细胞衍生的条件培养基/分泌组作为眼部疾病治疗选择的潜力。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-10-01 Epub Date: 2023-09-13 DOI: 10.2217/rme-2023-0089
Wesley Harrisson Bouche Djatche, Huimin Zhu, Wenlei Ma, Yue Li, Ziang Li, Hong Zhao, Zhizhen Liu, Hua Qiao
{"title":"Potential of mesenchymal stem cell-derived conditioned medium/secretome as a therapeutic option for ocular diseases.","authors":"Wesley Harrisson Bouche Djatche,&nbsp;Huimin Zhu,&nbsp;Wenlei Ma,&nbsp;Yue Li,&nbsp;Ziang Li,&nbsp;Hong Zhao,&nbsp;Zhizhen Liu,&nbsp;Hua Qiao","doi":"10.2217/rme-2023-0089","DOIUrl":"10.2217/rme-2023-0089","url":null,"abstract":"<p><p>Research has shown that the therapeutic effect of mesenchymal stem cells (MSCs) is partially due to its secreted factors as opposed to the implantation of the cells into the treated tissue or tissue replacement. MSC secretome, especially in the form of conditioned medium (MSC-CM) is now being explored as an alternative to MSCs transplantation. Despite the observed benefits of MSC-CM, only a few clinical trials have evaluated it and other secretome components in the treatment of eye diseases. This review provides insight into the potential therapeutic use of MSC-CM in eye conditions, such as corneal diseases, dry eye, glaucoma, retinal diseases and uveitis. We discuss the current evidence, some limitations, and the progress that remains to be achieved before clinical translation becomes possible.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"795-807"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10221650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling new trends in bone regeneration, using the BERTopic approach. 利用BERTopic方法对骨再生的新趋势进行建模。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0096
Stefano Guizzardi, Maria Teresa Colangelo, Prisco Mirandola, Carlo Galli
{"title":"Modeling new trends in bone regeneration, using the BERTopic approach.","authors":"Stefano Guizzardi,&nbsp;Maria Teresa Colangelo,&nbsp;Prisco Mirandola,&nbsp;Carlo Galli","doi":"10.2217/rme-2023-0096","DOIUrl":"https://doi.org/10.2217/rme-2023-0096","url":null,"abstract":"<p><p><b>Aim:</b> Bibliometric surveys are time-consuming endeavors, which cannot be scaled up to meet the challenges of ever-expanding fields, such as bone regeneration. Artificial intelligence, however, can provide smart tools to screen massive amounts of literature, and we relied on this technology to automatically identify research topics. <b>Materials & methods:</b> We used the BERTopic algorithm to detect the topics in a corpus of MEDLINE manuscripts, mapping their similarities and highlighting research hotspots. <b>Results:</b> Using BERTopic, we identified 372 topics and were able to assess the growing importance of innovative and recent fields of investigation such as 3D printing and extracellular vescicles. <b>Conclusion:</b> BERTopic appears as a suitable tool to set up automatic screening routines to track the progress in bone regeneration.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 9","pages":"719-734"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10273546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of transplantation of umbilical cord blood mononuclear cells into the scrotum on sexual function in elderly mice. 脐血单核细胞阴囊移植对老年小鼠性功能的影响。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2022-0191
Jun Li, Yinghong Jiang, Wei Xue, Lejiang Liu, Hua Yu, Xuemei Zhang, Xiao Ye, Jianrong Miao, Jianling Liu, Yueen Chen, Xingbin Lan, Xiaoqing Liu, Wensong Yao, Jianchuan Sun, Jing Zheng, Jianzhong Xiao
{"title":"Effects of transplantation of umbilical cord blood mononuclear cells into the scrotum on sexual function in elderly mice.","authors":"Jun Li,&nbsp;Yinghong Jiang,&nbsp;Wei Xue,&nbsp;Lejiang Liu,&nbsp;Hua Yu,&nbsp;Xuemei Zhang,&nbsp;Xiao Ye,&nbsp;Jianrong Miao,&nbsp;Jianling Liu,&nbsp;Yueen Chen,&nbsp;Xingbin Lan,&nbsp;Xiaoqing Liu,&nbsp;Wensong Yao,&nbsp;Jianchuan Sun,&nbsp;Jing Zheng,&nbsp;Jianzhong Xiao","doi":"10.2217/rme-2022-0191","DOIUrl":"https://doi.org/10.2217/rme-2022-0191","url":null,"abstract":"<p><p><b>Aim:</b> This study investigated the effect of allografting umbilical cord blood mononuclear cells (UCBMCs) into the scrotum on sexual function in male elderly mice. <b>Methods:</b> UCBMCs were injected once into the scrotal sheath cavity of elderly mice. <b>Results:</b> The transplanted UCBMCs survived in the scrotal sheath cavity for 1 month. The mice had significantly increased blood testosterone concentrations, cyclic guanosine monophosphate (cGMP) levels and total nitric oxide synthase (T-NOS) activity in the corpus cavernosum and an increase in the number of mouse matings within 30 min (all p = 0.000). <b>Conclusion:</b> Scrotum-implanted UCBMCs improve the sexual function of male elderly mice through testosterone production and the NOS/cGMP pathway, which may provide an innovative transplantation approach for the treatment of erectile dysfunction.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 9","pages":"695-706"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10221217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hope on the horizon: Wharton's jelly mesenchymal stem cells in the fight against COVID-19. 希望在地平线上:沃顿的果冻间充质干细胞在对抗COVID-19的斗争中。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0077
Gaurav Gupta, Md Sadique Hussain, Riya Thapa, Rajiv Dahiya, Debarshi Kar Mahapatra, Asif Ahmad Bhat, Neelam Singla, Vetriselvan Subramaniyan, Sushama Rawat, Vikas Jakhmola, Roshan S, Kamal Dua
{"title":"Hope on the horizon: Wharton's jelly mesenchymal stem cells in the fight against COVID-19.","authors":"Gaurav Gupta,&nbsp;Md Sadique Hussain,&nbsp;Riya Thapa,&nbsp;Rajiv Dahiya,&nbsp;Debarshi Kar Mahapatra,&nbsp;Asif Ahmad Bhat,&nbsp;Neelam Singla,&nbsp;Vetriselvan Subramaniyan,&nbsp;Sushama Rawat,&nbsp;Vikas Jakhmola,&nbsp;Roshan S,&nbsp;Kamal Dua","doi":"10.2217/rme-2023-0077","DOIUrl":"https://doi.org/10.2217/rme-2023-0077","url":null,"abstract":"of","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 9","pages":"675-678"},"PeriodicalIF":2.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10219290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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