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Exploring stem cell therapies: an interview with Darius Widera. 探索干细胞疗法：专访达柳斯-维德拉。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-01-01 Epub Date: 2024-07-18 DOI: 10.1080/17460751.2024.2375104
Darius Widera
{"title":"Exploring stem cell therapies: an interview with Darius Widera.","authors":"Darius Widera","doi":"10.1080/17460751.2024.2375104","DOIUrl":"10.1080/17460751.2024.2375104","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"375-377"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11373527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transforming organ transplantation with regenerative medicine: an interview with Giuseppe Orlando. 用再生医学转化器官移植:采访朱塞佩·奥兰多。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-01-01 Epub Date: 2023-11-13 DOI: 10.2217/rme-2023-0204
Giuseppe Orlando
{"title":"Transforming organ transplantation with regenerative medicine: an interview with Giuseppe Orlando.","authors":"Giuseppe Orlando","doi":"10.2217/rme-2023-0204","DOIUrl":"10.2217/rme-2023-0204","url":null,"abstract":"<p><p>Giuseppe Orlando is an Associate Professor of Surgery and a kidney and pancreas transplant surgeon scientist at Wake Forest University School of Medicine (Winston-Salem, North Carolina), and the President Elect of the Cell Transplant and Regenerative Medicine Society. With a research interest in bioengineering and the regeneration of transplantable organs, Giuseppe's work seeks to establish the link between transplant medicine and regenerative medicine.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"5-6"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89719378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental and computational approach to establish fit-for-purpose cell viability assays. 通过实验和计算方法建立适用的细胞活力测定方法。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-01-01 Epub Date: 2024-01-22 DOI: 10.2217/rme-2023-0154
Laura Pierce, Hidayah Anderson, Swarnavo Sarkar, Steven R Bauer, Sumona Sarkar
{"title":"Experimental and computational approach to establish fit-for-purpose cell viability assays.","authors":"Laura Pierce, Hidayah Anderson, Swarnavo Sarkar, Steven R Bauer, Sumona Sarkar","doi":"10.2217/rme-2023-0154","DOIUrl":"10.2217/rme-2023-0154","url":null,"abstract":"<p><p><b>Aim:</b> Cell viability assays are critical for cell-based products. Here, we demonstrate a combined experimental and computational approach to identify fit-for-purpose cell assays that can predict changes in cell proliferation, a critical biological response in cell expansion. <b>Materials & methods:</b> Jurkat cells were systematically injured using heat (45 ± 1°C). Cell viability was measured at 0 h and 24 h after treatment using assays for membrane integrity, metabolic function and apoptosis. Proliferation kinetics for longer term cultures were modeled using the Gompertz distribution to establish predictive models between cell viability results and proliferation. <b>Results & conclusion:</b> We demonstrate an approach for ranking these assays as predictors of cell proliferation and for setting cell viability specifications when a particular proliferation response is required.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"27-45"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139513560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in September 2023. 2023年9月来自干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2024-01-01 Epub Date: 2023-12-07 DOI: 10.2217/rme-2023-0217
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in September 2023.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.2217/rme-2023-0217","DOIUrl":"10.2217/rme-2023-0217","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in September 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"7-17"},"PeriodicalIF":2.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138499282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Signal transduction pathways alter the molecular cargo of extracellular vesicles: implications in regenerative medicine. 信号转导通路改变细胞外囊泡的分子货物:在再生医学中的意义。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2023-12-01 Epub Date: 2023-12-07 DOI: 10.2217/rme-2023-0183
Prajakta Teli, Anuradha Vaidya, Vaijayanti Kale
{"title":"Signal transduction pathways alter the molecular cargo of extracellular vesicles: implications in regenerative medicine.","authors":"Prajakta Teli, Anuradha Vaidya, Vaijayanti Kale","doi":"10.2217/rme-2023-0183","DOIUrl":"10.2217/rme-2023-0183","url":null,"abstract":"<p><p>Extracellular vesicles (EVs) possess regenerative properties and are also considered as future vaccines. All types of cells secrete EVs; however, the amount of EVs secreted by the cells varies under various physiological as well as pathological states. Several articles have reviewed the molecular composition and potential therapeutic applications of EVs. Likewise, the 'sorting signals' associated with specific macromolecules have also been identified, but how the signal transduction pathways prevailing in the parent cells alter the molecular profile of the EVs or the payload they carry has not been sufficiently reviewed. Here, we have specifically discussed the implications of these alterations in the macromolecular cargo of EVs for their therapeutic applications in regenerative medicine.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"935-944"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138499283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in August 2023. 2023年8月，干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-12-01 Epub Date: 2023-10-03 DOI: 10.2217/rme-2023-0181
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in August 2023.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.2217/rme-2023-0181","DOIUrl":"10.2217/rme-2023-0181","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in August 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"897-906"},"PeriodicalIF":2.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41132510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improved neurological function in a patient with complete spinal cord injury through bone marrow mesenchymal stem cells implantation: a case report. 骨髓间充质干细胞移植改善完全性脊髓损伤患者神经功能1例报告。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2023-12-01 Epub Date: 2023-11-22 DOI: 10.2217/rme-2023-0120
Ying-Chuan Kuan, Shinn-Zong Lin, Tsung-Lang Chiu, Hsiang-Yi Hung
{"title":"Improved neurological function in a patient with complete spinal cord injury through bone marrow mesenchymal stem cells implantation: a case report.","authors":"Ying-Chuan Kuan, Shinn-Zong Lin, Tsung-Lang Chiu, Hsiang-Yi Hung","doi":"10.2217/rme-2023-0120","DOIUrl":"10.2217/rme-2023-0120","url":null,"abstract":"<p><p><b>Aim:</b> Spinal cord injury (SCI) can cause severe disability. Several clinical trials of stem-cell based therapies are ongoing. We describe our experience of bone marrow mesenchymal stem cell (BMSC) therapy in a patient with complete SCI in the chronic stage. <b>Case report:</b> A 25-year-old man with complete SCI at T6 level presented with paraplegia for 5 years. We transplanted autologous BMSCs intramedullary. After 12 months follow-up, his Barthel index score was noticeably improved from severe to moderate dependency, and the sensation level improved from T7 to S5, but no improvement of motor function. <b>Conclusion:</b> Autologous BMSCs are potentially safe for patients with complete SCI in the chronic stage and may improve neurological function and quality of life.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"907-911"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138291702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modern regenerative medicine dictionary: an augmented guide to biotherapy. 现代再生医学词典:生物疗法的增强指南。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2023-12-01 Epub Date: 2023-11-14 DOI: 10.2217/rme-2023-0200
Andre Terzic
{"title":"Modern regenerative medicine dictionary: an augmented guide to biotherapy.","authors":"Andre Terzic","doi":"10.2217/rme-2023-0200","DOIUrl":"10.2217/rme-2023-0200","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"885-889"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10782411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92156317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 'one stone, two birds' approach with mesenchymal stem cells for acute respiratory distress syndrome and Type II diabetes mellitus. 利用间充质干细胞治疗急性呼吸窘迫综合征和 II 型糖尿病的 "一石二鸟 "法。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2023-12-01 Epub Date: 2023-12-19 DOI: 10.2217/rme-2023-0193
Mogesh Sababathy, Ghayathri Ramanathan, Nor Yasmin Abd Rahaman, Rajesh Ramasamy, Foo Jhi Biau, Daniel Looi Qi Hao, Nur-Fazila Saulol Hamid
{"title":"A 'one stone, two birds' approach with mesenchymal stem cells for acute respiratory distress syndrome and Type II diabetes mellitus.","authors":"Mogesh Sababathy, Ghayathri Ramanathan, Nor Yasmin Abd Rahaman, Rajesh Ramasamy, Foo Jhi Biau, Daniel Looi Qi Hao, Nur-Fazila Saulol Hamid","doi":"10.2217/rme-2023-0193","DOIUrl":"10.2217/rme-2023-0193","url":null,"abstract":"<p><p>This review explores the intricate relationship between acute respiratory distress syndrome (ARDS) and Type II diabetes mellitus (T2DM). It covers ARDS epidemiology, etiology and pathophysiology, along with current treatment trends and challenges. The lipopolysaccharides (LPS) role in ARDS and its association between non-communicable diseases and COVID-19 are discussed. The review highlights the therapeutic potential of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) for ARDS and T2DM, emphasizing their immunomodulatory effects. This review also underlines how T2DM exacerbates ARDS pathophysiology and discusses the potential of hUC-MSCs in modulating immune responses. In conclusion, the review highlights the multidisciplinary approach to managing ARDS and T2DM, focusing on inflammation, oxidative stress and potential therapy of hUC-MSCs in the future.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 12","pages":"913-934"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138807689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Keeping an eye on sustainable regeneration. 关注可持续再生。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2023-12-01 Epub Date: 2023-08-09 DOI: 10.2217/rme-2023-0142
Meklit G Shibru, Zehara M Ali, Sumayya Alali, Hessa Alkhoori, Peter R Corridon
{"title":"Keeping an eye on sustainable regeneration.","authors":"Meklit G Shibru, Zehara M Ali, Sumayya Alali, Hessa Alkhoori, Peter R Corridon","doi":"10.2217/rme-2023-0142","DOIUrl":"10.2217/rme-2023-0142","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"891-895"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9951537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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