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Industry updates from the field of stem cell research and regenerative medicine in September 2023. 2023年9月来自干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2024-01-01 Epub Date: 2023-12-07 DOI: 10.2217/rme-2023-0217
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in September 2023.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.2217/rme-2023-0217","DOIUrl":"10.2217/rme-2023-0217","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in September 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"7-17"},"PeriodicalIF":2.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138499282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Signal transduction pathways alter the molecular cargo of extracellular vesicles: implications in regenerative medicine. 信号转导通路改变细胞外囊泡的分子货物:在再生医学中的意义。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2023-12-01 Epub Date: 2023-12-07 DOI: 10.2217/rme-2023-0183
Prajakta Teli, Anuradha Vaidya, Vaijayanti Kale
{"title":"Signal transduction pathways alter the molecular cargo of extracellular vesicles: implications in regenerative medicine.","authors":"Prajakta Teli, Anuradha Vaidya, Vaijayanti Kale","doi":"10.2217/rme-2023-0183","DOIUrl":"10.2217/rme-2023-0183","url":null,"abstract":"<p><p>Extracellular vesicles (EVs) possess regenerative properties and are also considered as future vaccines. All types of cells secrete EVs; however, the amount of EVs secreted by the cells varies under various physiological as well as pathological states. Several articles have reviewed the molecular composition and potential therapeutic applications of EVs. Likewise, the 'sorting signals' associated with specific macromolecules have also been identified, but how the signal transduction pathways prevailing in the parent cells alter the molecular profile of the EVs or the payload they carry has not been sufficiently reviewed. Here, we have specifically discussed the implications of these alterations in the macromolecular cargo of EVs for their therapeutic applications in regenerative medicine.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"935-944"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138499283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in August 2023. 2023年8月，干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-12-01 Epub Date: 2023-10-03 DOI: 10.2217/rme-2023-0181
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in August 2023.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.2217/rme-2023-0181","DOIUrl":"10.2217/rme-2023-0181","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in August 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"897-906"},"PeriodicalIF":2.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41132510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improved neurological function in a patient with complete spinal cord injury through bone marrow mesenchymal stem cells implantation: a case report. 骨髓间充质干细胞移植改善完全性脊髓损伤患者神经功能1例报告。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2023-12-01 Epub Date: 2023-11-22 DOI: 10.2217/rme-2023-0120
Ying-Chuan Kuan, Shinn-Zong Lin, Tsung-Lang Chiu, Hsiang-Yi Hung
{"title":"Improved neurological function in a patient with complete spinal cord injury through bone marrow mesenchymal stem cells implantation: a case report.","authors":"Ying-Chuan Kuan, Shinn-Zong Lin, Tsung-Lang Chiu, Hsiang-Yi Hung","doi":"10.2217/rme-2023-0120","DOIUrl":"10.2217/rme-2023-0120","url":null,"abstract":"<p><p><b>Aim:</b> Spinal cord injury (SCI) can cause severe disability. Several clinical trials of stem-cell based therapies are ongoing. We describe our experience of bone marrow mesenchymal stem cell (BMSC) therapy in a patient with complete SCI in the chronic stage. <b>Case report:</b> A 25-year-old man with complete SCI at T6 level presented with paraplegia for 5 years. We transplanted autologous BMSCs intramedullary. After 12 months follow-up, his Barthel index score was noticeably improved from severe to moderate dependency, and the sensation level improved from T7 to S5, but no improvement of motor function. <b>Conclusion:</b> Autologous BMSCs are potentially safe for patients with complete SCI in the chronic stage and may improve neurological function and quality of life.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"907-911"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138291702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modern regenerative medicine dictionary: an augmented guide to biotherapy. 现代再生医学词典:生物疗法的增强指南。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2023-12-01 Epub Date: 2023-11-14 DOI: 10.2217/rme-2023-0200
Andre Terzic
{"title":"Modern regenerative medicine dictionary: an augmented guide to biotherapy.","authors":"Andre Terzic","doi":"10.2217/rme-2023-0200","DOIUrl":"10.2217/rme-2023-0200","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"885-889"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10782411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92156317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 'one stone, two birds' approach with mesenchymal stem cells for acute respiratory distress syndrome and Type II diabetes mellitus. 利用间充质干细胞治疗急性呼吸窘迫综合征和 II 型糖尿病的 "一石二鸟 "法。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2023-12-01 Epub Date: 2023-12-19 DOI: 10.2217/rme-2023-0193
Mogesh Sababathy, Ghayathri Ramanathan, Nor Yasmin Abd Rahaman, Rajesh Ramasamy, Foo Jhi Biau, Daniel Looi Qi Hao, Nur-Fazila Saulol Hamid
{"title":"A 'one stone, two birds' approach with mesenchymal stem cells for acute respiratory distress syndrome and Type II diabetes mellitus.","authors":"Mogesh Sababathy, Ghayathri Ramanathan, Nor Yasmin Abd Rahaman, Rajesh Ramasamy, Foo Jhi Biau, Daniel Looi Qi Hao, Nur-Fazila Saulol Hamid","doi":"10.2217/rme-2023-0193","DOIUrl":"10.2217/rme-2023-0193","url":null,"abstract":"<p><p>This review explores the intricate relationship between acute respiratory distress syndrome (ARDS) and Type II diabetes mellitus (T2DM). It covers ARDS epidemiology, etiology and pathophysiology, along with current treatment trends and challenges. The lipopolysaccharides (LPS) role in ARDS and its association between non-communicable diseases and COVID-19 are discussed. The review highlights the therapeutic potential of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) for ARDS and T2DM, emphasizing their immunomodulatory effects. This review also underlines how T2DM exacerbates ARDS pathophysiology and discusses the potential of hUC-MSCs in modulating immune responses. In conclusion, the review highlights the multidisciplinary approach to managing ARDS and T2DM, focusing on inflammation, oxidative stress and potential therapy of hUC-MSCs in the future.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 12","pages":"913-934"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138807689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Keeping an eye on sustainable regeneration. 关注可持续再生。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2023-12-01 Epub Date: 2023-08-09 DOI: 10.2217/rme-2023-0142
Meklit G Shibru, Zehara M Ali, Sumayya Alali, Hessa Alkhoori, Peter R Corridon
{"title":"Keeping an eye on sustainable regeneration.","authors":"Meklit G Shibru, Zehara M Ali, Sumayya Alali, Hessa Alkhoori, Peter R Corridon","doi":"10.2217/rme-2023-0142","DOIUrl":"10.2217/rme-2023-0142","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"891-895"},"PeriodicalIF":2.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9951537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bone marrow aspirate concentrate chondroplasty to delaying need for total knee arthroplasty: a retrospective review of a veteran cohort. 骨髓浓缩软骨成形术延迟全膝关节置换术的需要:一项对退伍军人队列的回顾性回顾。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-11-01 Epub Date: 2023-11-21 DOI: 10.2217/rme-2023-0124
Adam Pearl, Khaled Saleh, Diana Korsog, Jeffery Mundt
{"title":"Bone marrow aspirate concentrate chondroplasty to delaying need for total knee arthroplasty: a retrospective review of a veteran cohort.","authors":"Adam Pearl, Khaled Saleh, Diana Korsog, Jeffery Mundt","doi":"10.2217/rme-2023-0124","DOIUrl":"10.2217/rme-2023-0124","url":null,"abstract":"<p><p><b>Aim:</b> Osteoarthritis (OA) is a highly prevalent and costly condition, rooted in cartilaginous defects. Despite various causes, the inability for chondrocytes to regenerate prohibits these lesions from self-healing. Debridement commonly provides symptomatic relief but does not target the underlying disease process, necessitating investigation into possible treatments. Intraosseous and intraarticular bone marrow aspirate concentrate (BMAC) injection is a new promising therapy aimed at repairing these cartilage defects. <b>Methods/materials:</b> We retrospectively reviewed patients who underwent BMAC chondroplasty and examined the efficacy in delaying need for further intervention. <b>Results:</b> Only 5 of 23 procedures (21.7%) required postoperative intervention within the 2-year follow-up period. Only one request for total knee arthroplasty was made, but the procedure has not been done. <b>Conclusion:</b> This study demonstrates that BMAC chondroplasty may be an efficacious method to delay need for total knee arthroplasty.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"18 11","pages":"833-838"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138295809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in July 2023. 2023年7月，干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-11-01 Epub Date: 2023-09-20 DOI: 10.2217/rme-2023-0177
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in July 2023.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.2217/rme-2023-0177","DOIUrl":"10.2217/rme-2023-0177","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in July 2023.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"823-831"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41140927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulatory claims made by US businesses engaged in direct-to-consumer marketing of purported stem cell treatments and exosome therapies. 从事所谓干细胞治疗和外泌体疗法直接面向消费者营销的美国企业提出的监管要求。
IF 2.7 4区 医学
Regenerative medicine Pub Date : 2023-11-01 Epub Date: 2023-10-23 DOI: 10.2217/rme-2023-0117
Leigh Turner, Juan Ramon Martinez, Shemms Najjar, Thevin Rajapaksha Arachchilage, Victoria Sahrai, Jia Chieng Wang
{"title":"Regulatory claims made by US businesses engaged in direct-to-consumer marketing of purported stem cell treatments and exosome therapies.","authors":"Leigh Turner, Juan Ramon Martinez, Shemms Najjar, Thevin Rajapaksha Arachchilage, Victoria Sahrai, Jia Chieng Wang","doi":"10.2217/rme-2023-0117","DOIUrl":"10.2217/rme-2023-0117","url":null,"abstract":"<p><p><b>Aim:</b> This study investigated whether US businesses engaged in direct-to-consumer online marketing of purported stem cell therapies and stem cell-derived exosome products made claims concerning the regulatory status of these interventions. <b>Methods:</b> We used data mining and content analysis of company websites to examine regulatory-related representations made by US businesses marketing stem cell treatments and exosome therapies. <b>Results:</b> More than two thirds of such businesses did not make explicit representations about the regulatory status of their marketed products. Businesses that made claims about the regulatory status of the stem cell and exosome products they sold used range of representations concerning the legal standing of these interventions. <b>Conclusion:</b> The absence of information addressing the regulatory status of stem cell interventions and exosome products and the use of what appeared to be inaccurate information concerning the regulatory status of numerous products likely complicates efforts by customers to make informed health-related decisions.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"857-868"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49692131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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