{"title":"Industry updates from the field of stem cell research and regenerative medicine in February 2025.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2025.2483100","DOIUrl":"https://doi.org/10.1080/17460751.2025.2483100","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine were compiled from publicly available information and press releases from non-academic institutions in February 2025.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-8"},"PeriodicalIF":2.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Industry updates from the field of stem cell research and regenerative medicine in January 2025.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2025.2476349","DOIUrl":"https://doi.org/10.1080/17460751.2025.2476349","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in January 2025.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-8"},"PeriodicalIF":2.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Regenerative medicinePub Date : 2025-02-01Epub Date: 2025-01-19DOI: 10.1080/17460751.2025.2453325
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in November 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2025.2453325","DOIUrl":"10.1080/17460751.2025.2453325","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in November 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"20 2-3","pages":"65-72"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Regenerative medicinePub Date : 2025-02-01Epub Date: 2025-03-03DOI: 10.1080/17460751.2025.2472589
Oliver Dulic, Dzihan Abazovic, Sara Matijevic, Predrag Rasovic, Mirko Obradovic, Mile Bjelobrk, Milan Tosic, Ivica Lalic, Branko Baljak, Milan Milinkov
{"title":"Quality of life changes in patients suffering from knee osteoarthritis treated with bone marrow aspirate concentrate, platelet-rich plasma and hyaluronic acid injections.","authors":"Oliver Dulic, Dzihan Abazovic, Sara Matijevic, Predrag Rasovic, Mirko Obradovic, Mile Bjelobrk, Milan Tosic, Ivica Lalic, Branko Baljak, Milan Milinkov","doi":"10.1080/17460751.2025.2472589","DOIUrl":"10.1080/17460751.2025.2472589","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare the effects of different treatments on quality of life in knee osteoarthritis patients. It focused on three therapies: bone marrow aspirate concentrate (BMAC), platelet-rich plasma (PRP), and hyaluronic acid (HA).</p><p><strong>Methodology: </strong>The trial was conducted at a single center with 175 patients over a 12-month period with the knee OA, KL grade II-IV. Outcomes were measured using the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) and SF-36 scales, which assess physical and emotional well-being. Linear mixed models (LMMs) were used to analyze which treatment had the most positive impact on quality of life.</p><p><strong>Results: </strong>Patients treated with BMAC showed the most substantial improvement, particularly in physical health and mobility (<i>p</i> ≤ 0,001). PRP outperformed HA in some aspects, but BMAC consistently led to greater gains. The most notable enhancements were seen in areas like role limitations due to physical health and overall physical functioning.</p><p><strong>Conclusions: </strong>The study suggested that BMAC treatment may contribute to improved quality of life in patients with knee osteoarthritis, particularly in terms of physical function. The correlation between WOMAC and SF-36 scores supports these findings, indicating a potential role for BMAC in enhancing mobility.</p><p><strong>Clinical trial registration: </strong>NCT03825133 (ClinicalTrials.gov).</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"87-96"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Regenerative medicinePub Date : 2025-02-01Epub Date: 2025-03-03DOI: 10.1080/17460751.2025.2472578
Ilayda Korkmaz, Mehmet Gurdal, Mesut Arici, Ozlem Barut Selver
{"title":"Beyond transplants: current and future therapeutic potential of amniotic membrane extract (AME) in ophthalmology.","authors":"Ilayda Korkmaz, Mehmet Gurdal, Mesut Arici, Ozlem Barut Selver","doi":"10.1080/17460751.2025.2472578","DOIUrl":"10.1080/17460751.2025.2472578","url":null,"abstract":"<p><p>There is no established consensus or standardized method for the preparation of amniotic membrane extract (AME). Consequently, various preparation, preservation, and sterilization techniques have been employed. To obtain AME rich in bioactive components with high therapeutic efficacy, each step of the preparation process is of critical importance. The appropriate procurement of the amniotic membrane minimizes the risk of infection transmission and reduces inter- and intra-donor variability. For the subsequent extraction process, different approaches are utilized due to factors such as laboratory infrastructure variability and the lack of a standardized method. Although lyophilization has recently emerged as a prominent method for the long-term preservation of AME, further investigation is required to assess its impact on the biochemical composition and clinical efficacy of the membrane. In ophthalmology, <i>in vitro</i>, <i>in vivo</i>, and clinical studies indicate that AME supports corneal epithelial regeneration, suppresses inflammation, and is a well-tolerated therapeutic agent. Consequently, further studies are still needed to enhance the effective release of therapeutic components from the amniotic membrane, improve the quality and consistency of AME, and preserve its content over an extended period. Thus, the clinical application of AME-derived products in the form of eye drops will become more widespread in the future.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"97-109"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Regenerative medicinePub Date : 2025-02-01Epub Date: 2024-12-27DOI: 10.1080/17460751.2024.2445466
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in October 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2024.2445466","DOIUrl":"10.1080/17460751.2024.2445466","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in October 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"57-63"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Regenerative medicinePub Date : 2025-02-01Epub Date: 2025-03-18DOI: 10.1080/17460751.2025.2476390
Simão Laranjeira, Owein Guillemot-Legris, Gedion Girmahun, James B Phillips, Rebecca J Shipley
{"title":"Open-source software to calculate the static sciatic index automatically.","authors":"Simão Laranjeira, Owein Guillemot-Legris, Gedion Girmahun, James B Phillips, Rebecca J Shipley","doi":"10.1080/17460751.2025.2476390","DOIUrl":"10.1080/17460751.2025.2476390","url":null,"abstract":"<p><strong>Background: </strong>The static sciatic index is commonly used in rat models of nerve crush injury to quantify functional recovery from new therapies under evaluation. However, it is challenging to standardize these measurements across different investigations, and the process is labor intensive.</p><p><strong>Material/methods: </strong>A new machine learning method was previously developed that performs these measurements automatically and consistently. Here, the approach is tested using two data sets that use different experimental setups, and end-user requirements are evaluated.</p><p><strong>Results: </strong>The model's outputs presented a nerve regeneration profile comparable to the manual measurements and outperformed the latter by having a much tighter standard deviation (± 5- ± 10 compared to ± 10 - ± 50).</p><p><strong>Conclusion: </strong>An inexpensive automatic tool that can perform functional analysis for nerve repair research was developed and tested. The software is available open source to facilitate its dissemination and use in quantifying recovery from peripheral nerve crush injury.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"77-85"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Industry updates from the field of stem cell research and regenerative medicine in November 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2025.2453325","DOIUrl":"https://doi.org/10.1080/17460751.2025.2453325","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in November 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-8"},"PeriodicalIF":2.4,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}