Regenerative medicine最新文献

Industry updates in advanced therapy medicinal products and regenerative medicine - March 2026. 先进治疗药物产品和再生医学的行业更新- 2026年3月。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-04-26 DOI: 10.1080/17460751.2026.2663180

Dusko Ilic, Mirjana Liovic

引用次数: 0

Industry updates in advanced therapy medicinal products and regenerative medicine - February 2026. 先进治疗药物产品和再生医学的行业更新- 2026年2月。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-03-18 DOI: 10.1080/17460751.2026.2646590

Dusko Ilic, Mirjana Liovic

引用次数: 0

Industry updates in advanced therapy medicinal products and regenerative medicine in January 2026. 2026年1月先进治疗药物产品和再生医学行业更新。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-03-02 DOI: 10.1080/17460751.2026.2638904

Dusko Ilic, Mirjana Liovic

引用次数: 0

Multilineage-differentiating stress-enduring (Muse) cells in ischemic heart disease. A systematic review of preclinical and clinical studies. 缺血性心脏病中的多谱系分化应激耐受（Muse）细胞临床前和临床研究的系统综述。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-03-01 Epub Date: 2026-04-23 DOI: 10.1080/17460751.2026.2663179

Antonio Madrazo-Ibarra, Ashrita Seelan, Kaitlin M Carroll, Vijay B Vad

{"title":"Multilineage-differentiating stress-enduring (Muse) cells in ischemic heart disease. A systematic review of preclinical and clinical studies.","authors":"Antonio Madrazo-Ibarra, Ashrita Seelan, Kaitlin M Carroll, Vijay B Vad","doi":"10.1080/17460751.2026.2663179","DOIUrl":"10.1080/17460751.2026.2663179","url":null,"abstract":"Background: Multilineage-differentiating stress-enduring (Muse) cells are endogenous pluripotent stromal cells with immunomodulatory and regenerative properties. Their ability to migrate to injured tissue and differentiate into multiple lineages has generated interest in ischemic heart disease (IHD).Methods: We conducted a systematic review using four databases which searched through July 2025 to identify preclinical and clinical studies of Muse cells in acute myocardial infarction (AMI) or coronary artery disease (CAD). Two reviewers independently performed data extraction and risk-of-bias assessment.Results: Seven studies met inclusion criteria: four preclinical and three clinical. Preclinical models consistently showed that Muse cells localized to the infarct border zone, reduced infarct size, improved ventricular function, limited remodeling, and enhanced angiogenesis. Gene expression confirmed differentiation toward cardiac and vascular lineages. No immune reactions or tumor formation were reported, even with allogeneic or xenogeneic cells. Clinical studies demonstrated increased circulating Muse cells after AMI or exercise, with greater mobilization linked to improved ventricular function and reduced remodeling. A first-in-human trial reported improved ejection fraction without adverse events after allogeneic Muse cell infusion.Conclusion: Available evidence suggests that Muse cells are safe and may support cardiac repair after ischemic injury. Larger randomized trials are needed to confirm efficacy and long-term safety.Protocol registration identifier: CRD420251105256.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"281-290"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Industry updates from the field of stem cell research and regenerative medicine in December 2025. 2025年12月来自干细胞研究和再生医学领域的行业更新。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-03-01 Epub Date: 2026-01-14 DOI: 10.1080/17460751.2026.2614636

Dusko Ilic, Mirjana Liovic

引用次数: 0

Stress kinases negatively regulate the multipotency of mesenchymal stem/stromal cells in vitro: implications in regenerative medicine. 应激激酶在体外负调控间充质干细胞/基质细胞的多能性：在再生医学中的意义

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-03-01 Epub Date: 2026-04-28 DOI: 10.1080/17460751.2026.2665223

Prajakta Teli, Anuradha Vaidya, Vaijayanti Kale

{"title":"Stress kinases negatively regulate the multipotency of mesenchymal stem/stromal cells in vitro: implications in regenerative medicine.","authors":"Prajakta Teli, Anuradha Vaidya, Vaijayanti Kale","doi":"10.1080/17460751.2026.2665223","DOIUrl":"10.1080/17460751.2026.2665223","url":null,"abstract":"The therapeutic efficacy of Mesenchymal stromal cells (MSCs) has been attributed to two mechanisms: one, the transdifferentiation of MSCs into tissue-specific cells and their integration into the affected tissue, and two, the reparative effects of their secretome. While the latter mechanism is now widely accepted, the ability of MSCs to transdifferentiate into non-mesodermal lineages remains highly debated. Nonetheless, several recent studies have shown that MSCs can differentiate into non-mesodermal lineages under specialized conditions. These studies are reviewed here. Notably, cultured MSCs exhibit activation of stress-kinases, and inhibition of these kinases has been shown to enhance the regenerative potential of MSCs; however, the underlying mechanisms involved in this improved potency remain poorly understood. This review also covers existing literature on the effects of stress kinase inhibition on MSC differentiation and functional potency, with an emphasis on therapeutic implications. Here, we propose a novel hypothesis that under conventional culture conditions, stress kinases negatively regulate the differentiation potency of MSCs and limit their multi-lineage potential. Inhibition of these kinases may not drive full lineage commitment that could qualify as transdifferentiation, but instead induce a quasi-differentiated or \"primed\" MSC state. Such primed MSCs may secrete lineage-specific reparative factors that enhance tissue repair and regeneration.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"269-279"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of decellularization strategy on the structural and biological integrity of human dermis: a comparative analysis of three decellularization methods. 脱细胞策略对人体真皮结构和生物完整性的影响：三种脱细胞方法的比较分析。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-03-01 Epub Date: 2026-05-04 DOI: 10.1080/17460751.2026.2668443

Elahe Mahdipour, Niloofar Khandan-Nasab, Parisa Abbasi, Samaneh Rezaei, Ali Ahmadabadi

{"title":"The impact of decellularization strategy on the structural and biological integrity of human dermis: a comparative analysis of three decellularization methods.","authors":"Elahe Mahdipour, Niloofar Khandan-Nasab, Parisa Abbasi, Samaneh Rezaei, Ali Ahmadabadi","doi":"10.1080/17460751.2026.2668443","DOIUrl":"10.1080/17460751.2026.2668443","url":null,"abstract":"Introduction: Acellular dermal matrices are increasingly applied in regenerative medicine and wound healing because they mimic native dermal structure and exhibit low immunogenicity. However, decellularization methods vary, and no consensus exists on the optimal protocol for human full-thickness dermis. This study compared three decellularization approaches to identify the most effective method for generating biocompatible, structurally preserved acellular dermis suitable for clinical use.Methods: Full-thickness human dermis was processed using: (1) alkaline NaOH treatment, (2) Triton X-100 followed by mild alkali, and (3) freeze-thaw cycling with surfactant and sonication. The resulting scaffolds were assessed macroscopically, histologically, and through cytocompatibility assays. In vivo wound healing was evaluated in a murine full-thickness wound model.Results: Alkaline treatment effectively removed cells but damaged the extracellular matrix, reducing mechanical strength and biocompatibility. Triton X-100-based and freeze-thaw/surfactant protocols preserved dermal architecture and mechanical integrity while ensuring complete decellularization and cytocompatibility. Both supported improved cellular infiltration and tissue remodeling in vivo. Neoangiogenesis and graft orientation showed minimal influence on healing.Conclusion: Triton X-100-based and freeze-thaw/surfactant protocols achieved optimal balance between cell removal and matrix preservation, offering promising strategies for producing clinically applicable acellular dermal scaffolds.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"255-267"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147820177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors that influence trust in non-standard stem cell therapies among patients with musculoskeletal conditions: a qualitative, constructivist grounded theory study. 影响非标准干细胞治疗对肌肉骨骼疾病患者信任的因素：一项定性的、建构主义的理论研究

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-03-01 Epub Date: 2026-04-29 DOI: 10.1080/17460751.2026.2665221

Marina Shaker, Amy Zarzeczny

{"title":"Factors that influence trust in non-standard stem cell therapies among patients with musculoskeletal conditions: a qualitative, constructivist grounded theory study.","authors":"Marina Shaker, Amy Zarzeczny","doi":"10.1080/17460751.2026.2665221","DOIUrl":"10.1080/17460751.2026.2665221","url":null,"abstract":"Aims: Stem cell interventions (SCIs) are an exciting area of regenerative medicine (RM) that may offer improved outcomes for many patients, including those suffering from musculoskeletal conditions. They can also raise regulatory tensions and policy challenges, including how to manage direct-to-consumer markets where nonstandard SCIs - those falling outside the standard of care and lacking sufficient evidence of safety or efficacy - are sold. Ongoing regulatory reform efforts in several countries, including Canada, to address these and other related issues would benefit from insights regarding what is important to patients for trust in SCIs and their providers.Materials and methods: Through interviews involving eight participants with musculoskeletal conditions, this qualitative, constructivist grounded theory study presents a preliminary model of factors that influence some patients' trust in nonstandard SCIs.Results and conclusions: Participants' anticipated approaches to nonstandard SCIs were rooted in their lived experiences of pain and frustration, shaped through interactions with healthcare providers, and framed by assumptions about regulatory protection. Healthcare providers play a pivotal role in helping navigate and interpret information. These results highlight the importance of evidence-based approaches to governance that integrate patient voices, practitioner education, and regulatory accountability to protect patients and help advance responsible RM innovation.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"243-254"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and feasibility of allogenic keratinocyte sheet application for deep second degree burn; SAFEALLOSHEET: phase I clinical trial. 异体角化细胞片应用于深二度烧伤的安全性和可行性SAFEALLOSHEET: I期临床试验。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-03-01 Epub Date: 2026-04-20 DOI: 10.1080/17460751.2026.2659023

Shayan Farzanbakhsh, Mostafa Dahmardehei, Hoda Madani, Nasrin Fallah, Bahareh Sadri, Alireza Beheshti Maal, Seyedeh Nafiseh Hassani, Azam Samadian, Raheleh Aghdami, Zahra Khalajasadi, Azadeh Rakhshan, Hossein Baharvand, Ensiyeh Hajizadeh-Saffar, Massoud Vosough

{"title":"Safety and feasibility of allogenic keratinocyte sheet application for deep second degree burn; SAFEALLOSHEET: phase I clinical trial.","authors":"Shayan Farzanbakhsh, Mostafa Dahmardehei, Hoda Madani, Nasrin Fallah, Bahareh Sadri, Alireza Beheshti Maal, Seyedeh Nafiseh Hassani, Azam Samadian, Raheleh Aghdami, Zahra Khalajasadi, Azadeh Rakhshan, Hossein Baharvand, Ensiyeh Hajizadeh-Saffar, Massoud Vosough","doi":"10.1080/17460751.2026.2659023","DOIUrl":"10.1080/17460751.2026.2659023","url":null,"abstract":"Aims: Deep second-degree burns often require autografting, but donor-site limitations highlight the need for alternative biological coverings. This study evaluated the safety and feasibility of allogeneic cultured keratinocyte sheets for acute burn wounds.Patients and methods: Five patients with 20-50% total body surface area burns were enrolled. A 60 cm2 wound site in each patient received the sheet, while the remaining areas were treated with standard autologous grafts. Patients were followed for 6 months. Primary endpoints were safety and feasibility; secondary endpoints included graft take, wound closure time, and scar quality assessed by Vancouver Scar Scale (VSS) and Patient and Observer Scar Assessment Scale (POSAS). Histopathology was performed at baseline and 6 months.Results: No serious adverse events occurred; only minor, self-limited reactions were observed. Keratinocyte sheets demonstrated near-complete take without immune responses. Wound closure occurred within 1 month in two patients and by 3 months in the others. POSAS patient scores improved from 28.4 ± 9.8 to 19.2 ± 6.0, and observer scores from 21.2 ± 3.8 to 14.2 ± 5.1. VSS decreased from 5.0 ± 2.1 to 3.6 ± 2.4. Histology confirmed favorable epithelialization.Conclusions: Allogeneic keratinocyte sheets were safe, feasible, and improved healing and scar quality.Clinical trial registration: Iranian Registry of Clinical Trials (IRCT), https://irct.ir/trial/62833; identifier is IRCT20080728001031N31.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"231-241"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Industry updates from the field of stem cell research and regenerative medicine in November 2025. 2025年11月来自干细胞研究和再生医学领域的行业更新。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-03-01 Epub Date: 2026-01-18 DOI: 10.1080/17460751.2026.2614637

Dusko Ilic, Mirjana Liovic

引用次数: 0