Regenerative medicine最新文献_第2页

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IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-03-01 Epub Date: 2026-03-09 DOI: 10.1080/17460751.2026.2642512

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IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-03-01 Epub Date: 2026-03-10 DOI: 10.1080/17460751.2026.2642511

引用次数: 0

Extracellular vesicle therapy for spinal cord injury: engineering-enhanced strategies and combination therapies. 脊髓损伤的细胞外囊泡治疗：工程增强策略和联合治疗。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-02-24 DOI: 10.1080/17460751.2026.2636634

Lin Zhang, Linlin Dong, Zhongli Dong

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Industry updates from the field of stem cell research and regenerative medicine in October 2025. 2025年10月来自干细胞研究和再生医学领域的行业更新。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-02-01 Epub Date: 2025-11-25 DOI: 10.1080/17460751.2025.2591068

Dusko Ilic, Mirjana Liovic

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Mesenchymal stem/stromal cell secretomes generated in serum free conditions and on clinically relevant plasma polymerized membranes promote fibroblast wound healing activity. 无血清条件下和临床相关的血浆聚合膜上产生的间充质干细胞/基质细胞分泌组促进成纤维细胞伤口愈合活性。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-02-01 Epub Date: 2026-03-05 DOI: 10.1080/17460751.2026.2638902

Harish Deepak Ghaisas, Jide Tope Olanipekun, Karthik Vaidya, Jees Thomas, Shilpy Dantuluri, Tejaswi Naradasu, Ruth Taylor, David Haddow, Vesna Stanulovic, Maarten Hoogenkamp, Douglas Ward, Geoffrey Brown, Charlotte H Hulme, Karina T Wright, Hideaki Nakajima, William Eustace Basil Johnson

{"title":"Mesenchymal stem/stromal cell secretomes generated in serum free conditions and on clinically relevant plasma polymerized membranes promote fibroblast wound healing activity.","authors":"Harish Deepak Ghaisas, Jide Tope Olanipekun, Karthik Vaidya, Jees Thomas, Shilpy Dantuluri, Tejaswi Naradasu, Ruth Taylor, David Haddow, Vesna Stanulovic, Maarten Hoogenkamp, Douglas Ward, Geoffrey Brown, Charlotte H Hulme, Karina T Wright, Hideaki Nakajima, William Eustace Basil Johnson","doi":"10.1080/17460751.2026.2638902","DOIUrl":"10.1080/17460751.2026.2638902","url":null,"abstract":"Background/aims: Mesenchymal stem/stromal cells (MSCs) are known to secrete wound healing factors. However, the delivery of the MSCs and their secretomes remains a barrier to the development of a successful regenerative medicine. Therefore, we examined the content and paracrine activity of serum free MSC conditioned media (MSC CM) generated in routine tissue culture and when cultured on a plasma polymerized membrane previously used clinically in cell therapies for skin wounds.Methods: Serum free MSC CM from murine and human MSC cultures were subjected to proteomic analysis by mass spectrometry and quantitative immunoassays and their paracrine effects were tested on dermal fibroblasts in vitro.Results: MSC CM contained multiple wound healing factors, including extracellular matrix proteins and soluble factors. MSC CM harvested from flask cultures and plasma polymerized membrane cultures significantly increased dermal fibroblast adhesion, proliferation, and scratch wound closure (for mouse MSC CM) compared to control media.Conclusion: This study has: (i) shown that MSC secreted factors increased dermal fibroblast activities seen in wound healing; (ii) identified target factors potentially responsible for these paracrine effects; (iii) shown that MSC secretomes generated on a plasma polymerized membrane used in skin cell therapies also have wound healing paracrine effects.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"139-154"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147356133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver bioengineering for regeneration: advances in liver disease modeling approaches and decellularization strategies. 肝脏再生生物工程：肝脏疾病建模方法和脱细胞策略的进展。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-02-01 Epub Date: 2026-04-10 DOI: 10.1080/17460751.2026.2655599

Aylin Acun, Kamryn R Purpura, Jah-Vanah F Francis, Kohlen N Kpuyuf, Kaila L Barnes

{"title":"Liver bioengineering for regeneration: advances in liver disease modeling approaches and decellularization strategies.","authors":"Aylin Acun, Kamryn R Purpura, Jah-Vanah F Francis, Kohlen N Kpuyuf, Kaila L Barnes","doi":"10.1080/17460751.2026.2655599","DOIUrl":"10.1080/17460751.2026.2655599","url":null,"abstract":"The global shortage of donor organs and the limitations of conventional in vitro models stress the urgent need for advanced liver tissue engineering and regenerative medicine strategies. These approaches aim to create physiologically relevant platforms for drug testing and develop transplantable tissues to restore liver function. Decellularization offers unique advantages by providing native extracellular matrix architecture and biochemical cues that support cell adhesion, differentiation, and vascularization. Complementary technologies such as three-dimensional (3D) bioprinting and microfluidics enable precise spatial organization of multiple cell types and dynamic perfusion, improving tissue functionality and disease modeling. Together, these innovations facilitate the development of high-fidelity liver constructs and organ-on-chip systems for studying pathologies like fibrosis and steatosis, as well as for preclinical drug screening. In this review we summarize current methods for liver decellularization and explore its role as a regenerative medicine strategy. We also examine applications in disease modeling, with emphasis on 3D bioprinting and microfluidic platforms, and discusses emerging vascularization techniques. Collectively, these insights highlight the progress and remaining challenges in engineering functional liver tissues for clinical and research applications.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"163-185"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative study of the effects of subcutaneously administered umbilical cord-derived mesenchymal stem cells and exosomes derivatives on wound healing in a chemical burn model of alkaline-induced skin burns. 皮下注射脐带间充质干细胞和外泌体衍生物对碱致皮肤烧伤化学烧伤模型伤口愈合影响的比较研究。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-02-01 Epub Date: 2026-03-04 DOI: 10.1080/17460751.2026.2638911

Hamit Hakan Bekir, Mehmet Gurdal, Ozlem Barut Selver, Banu Yaman, Cansu Subasi Demir, Meltem Kocamanoglu, Ayberk Sahin, Ahmet Bicer

{"title":"Comparative study of the effects of subcutaneously administered umbilical cord-derived mesenchymal stem cells and exosomes derivatives on wound healing in a chemical burn model of alkaline-induced skin burns.","authors":"Hamit Hakan Bekir, Mehmet Gurdal, Ozlem Barut Selver, Banu Yaman, Cansu Subasi Demir, Meltem Kocamanoglu, Ayberk Sahin, Ahmet Bicer","doi":"10.1080/17460751.2026.2638911","DOIUrl":"10.1080/17460751.2026.2638911","url":null,"abstract":"Background: In burn-injured skin, the main goal is to accelerate wound healing and restore the barrier. In chemical burns, excessive inflammation and deep tissue damage complicate repair. Regenerative medicine approaches may modulate these processes. This study investigated the effects of human umbilical cord-derived mesenchymal stem cells (HucMSCs) and their exosomes (Exo-HucMSCs) on wound healing in a chemical burn model.Methods: A chemical burn was induced on the dorsal skin of 24 Wistar rats using 2 M sodium hydroxide. Rats were randomly assigned to three groups (n = 8): HucMSC-treated, Exo-HucMSC-treated and control. Wound closure and histopathological changes were evaluated and compared among groups.Results: Wound closure was higher in the HucMSC group (78.15% ± 9.19) than in the Exo-HucMSC (66.11% ± 7.33) and control groups (57.35% ± 4.54) (p < 0.05). Histologically, treatment groups showed early inflammatory changes on days 1 and 3 (p < 0.01), enhanced striated muscle regeneration on day 7 (p < 0.01) and narrower non-epithelialized areas on day 21 (p < 0.05). Neoangiogenesis was greater in the Exo-HucMSC group on day 3 (p < 0.01).Conclusion: Both HucMSC and Exo-HucMSC treatment accelerated chemical burn healing. Exosomes promoted early-phase angiogenesis, whereas HucMSCs provided superior long-term wound closure.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"125-137"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147356136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementing stem-cell therapies for limbal stem cell deficiency. 实施干细胞治疗角膜缘干细胞缺乏症。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-02-01 Epub Date: 2026-03-10 DOI: 10.1080/17460751.2026.2638088

Eldo Galo, Francisco C Figueiredo, Majlinda Lako, Lyle Armstrong

{"title":"Implementing stem-cell therapies for limbal stem cell deficiency.","authors":"Eldo Galo, Francisco C Figueiredo, Majlinda Lako, Lyle Armstrong","doi":"10.1080/17460751.2026.2638088","DOIUrl":"10.1080/17460751.2026.2638088","url":null,"abstract":"Limbal stem cell deficiency (LSCD) is a severe ocular surface disorder that remains a major therapeutic challenge, particularly in bilateral disease where autologous limbal tissue is unavailable. Over the past three decades, stem cell-based interventions have transformed LSCD management, evolving from large limbal grafts to refined ex vivo expansion techniques and alternative stem cell sources. Despite these advances, long-term clinical outcomes remain variable and are strongly influenced by disease severity, immune rejection, stem cell quality, and optimization of the ocular surface microenvironment. This report examines the current landscape of surgical and stem cell-based therapies for LSCD, including autologous and allogeneic limbal epithelial transplantation, simple limbal epithelial transplantation, oral mucosa-derived approaches, mesenchymal stem cell therapies, and emerging induced pluripotent stem cell-derived corneal epithelium. We highlight key clinical outcomes, biological limitations, and translational challenges. Finally, we discuss future directions required to improve therapeutic efficacy and accessibility, including improved stem cell characterization and the development of hypoimmune or universal donor cell products.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"155-162"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfragmented adipose tissue in orthopedic regeneration: mechanisms, clinical evidence, and regulatory perspectives. 骨科再生中的微碎片化脂肪组织：机制、临床证据和调控观点。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-02-01 Epub Date: 2026-03-20 DOI: 10.1080/17460751.2026.2643235

Tarishi Parmar, Shriyaus Lingam, Jehad AlSamhori, Jonathan Elias, Imad Ashkar, Muhammad Hamza Ilyas, Mohammad Daher, Joseph A Abboud

{"title":"Microfragmented adipose tissue in orthopedic regeneration: mechanisms, clinical evidence, and regulatory perspectives.","authors":"Tarishi Parmar, Shriyaus Lingam, Jehad AlSamhori, Jonathan Elias, Imad Ashkar, Muhammad Hamza Ilyas, Mohammad Daher, Joseph A Abboud","doi":"10.1080/17460751.2026.2643235","DOIUrl":"10.1080/17460751.2026.2643235","url":null,"abstract":"Microfragmented adipose tissue (MFAT) has emerged as a minimally manipulated, autologous orthobiologic for musculoskeletal disorders, with the Lipogems system representing one of the most widely studied platforms. By preserving the stromal vascular niche and pericyte-rich microenvironment, MFAT provides a ready-to-use biologic without enzymatic digestion or ex vivo expansion. This narrative review synthesizes the biological rationale, clinical applications, and comparative effectiveness of MFAT across major orthopedic indications. We review action mechanisms, patient selection factors, procedural considerations, and regulatory context, with emphasis on outcomes, durability, and imaging correlations. Across joints, MFAT has demonstrated consistent improvements in pain and function, particularly in early to moderate osteoarthritis. However, radiographic findings are heterogeneous and often discordant with clinical outcomes. Studies suggest MFAT offers outcomes comparable to platelet-rich plasma and bone marrow aspirate concentrate rather than clear superiority. Overall, the evidence base is dominated by low- to moderate-level studies with small sample sizes, protocol variability, and limited follow-up. This review provides a cross-joint clinical synthesis to contextualize MFAT's current role in orthopedic practice, highlighting its procedural simplicity and favorable safety profile. Despite encouraging clinical signals, we strongly underscore the need for future high-quality trials, standardized methodologies, and cost-effectiveness analyses to define its long-term clinical utility.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"187-199"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147491649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical applications of induced pluripotent stem cell-mediated therapies in cancer: progress, challenges, and future directions. 诱导多能干细胞介导的癌症治疗的临床应用：进展、挑战和未来方向。

IF 2.6 4区医学

Regenerative medicine Pub Date : 2026-01-01 Epub Date: 2026-02-23 DOI: 10.1080/17460751.2026.2629846

Zahraa AlKhafaje, H Malathi, Aniruddh Dash, Selvakumari J Precilla, Gurjant Singh, Aashna Sinha, Muath Suliman, Aseel Smerat

{"title":"Clinical applications of induced pluripotent stem cell-mediated therapies in cancer: progress, challenges, and future directions.","authors":"Zahraa AlKhafaje, H Malathi, Aniruddh Dash, Selvakumari J Precilla, Gurjant Singh, Aashna Sinha, Muath Suliman, Aseel Smerat","doi":"10.1080/17460751.2026.2629846","DOIUrl":"10.1080/17460751.2026.2629846","url":null,"abstract":"Induced pluripotent stem cells (iPSCs) have emerged as a transformative platform for developing innovative therapies against hematological malignancies. Their pluripotent nature allows differentiation into functional immune effector cells, enabling the generation of iPSC-derived chimeric antigen receptor (CAR)-T and CAR-natural killer (NK) cells as scalable \"off-the-shelf\" immunotherapies that overcome donor limitations and immune rejection. These engineered immune cells exhibit improved specificity, persistence, and cytotoxicity against leukemia and lymphoma. Moreover, iPSCs hold great promise in regenerative hematology, as they facilitate bone marrow recovery after chemotherapy or radiation-induced damage, thereby enhancing hematopoietic function in cancer survivors. Despite these advances, clinical translation remains challenged by the risks of teratoma formation, manufacturing complexity, and cost. Until these issues are mitigated, widespread clinical application will be thwarted. Yet ongoing research holds the key to unlocking their potential to transform personalized cancer therapy by improving the effectiveness, safety, and availability of innovative immunotherapies.","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"91-110"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0