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The future of ex vivo hematopoietic stem cell gene editing: what's next. 体外造血干细胞基因编辑的未来：下一步是什么？
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-02-01 Epub Date: 2025-03-26 DOI: 10.1080/17460751.2025.2480003
Alessia Cavazza, Giorgia Santilli
{"title":"The future of ex vivo hematopoietic stem cell gene editing: what's next.","authors":"Alessia Cavazza, Giorgia Santilli","doi":"10.1080/17460751.2025.2480003","DOIUrl":"10.1080/17460751.2025.2480003","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"73-76"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in November 2024. 2024年11月来自干细胞研究和再生医学领域的行业更新。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-01-19 DOI: 10.1080/17460751.2025.2453325
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in November 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2025.2453325","DOIUrl":"https://doi.org/10.1080/17460751.2025.2453325","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in November 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-8"},"PeriodicalIF":2.4,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in December 2024. 2024年12月来自干细胞研究和再生医学领域的行业更新。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-01-18 DOI: 10.1080/17460751.2025.2453324
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in December 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2025.2453324","DOIUrl":"https://doi.org/10.1080/17460751.2025.2453324","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in December 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-9"},"PeriodicalIF":2.4,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generating functional cardiac tissue for regenerative medicine applications: a 3D bioprinting approach. 为再生医学应用生成功能性心脏组织：3D生物打印方法。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-01-01 Epub Date: 2025-02-21 DOI: 10.1080/17460751.2025.2469433
Boeun Hwang, Holly Bauser-Heaton, Vahid Serpooshan
{"title":"Generating functional cardiac tissue for regenerative medicine applications: a 3D bioprinting approach.","authors":"Boeun Hwang, Holly Bauser-Heaton, Vahid Serpooshan","doi":"10.1080/17460751.2025.2469433","DOIUrl":"10.1080/17460751.2025.2469433","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"11-15"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of increasingly complex cell culture conditions on the proteome of human periodontal ligament stem cells. 日益复杂的细胞培养条件对人牙周韧带干细胞蛋白质组的影响。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-01-01 Epub Date: 2025-01-04 DOI: 10.1080/17460751.2024.2445931
Asier Fullaondo, Mar Zalduendo, Nerea Osinalde, Mohammad H Alkhraisat, Eduardo Anitua, Ana M Zubiaga
{"title":"Impact of increasingly complex cell culture conditions on the proteome of human periodontal ligament stem cells.","authors":"Asier Fullaondo, Mar Zalduendo, Nerea Osinalde, Mohammad H Alkhraisat, Eduardo Anitua, Ana M Zubiaga","doi":"10.1080/17460751.2024.2445931","DOIUrl":"10.1080/17460751.2024.2445931","url":null,"abstract":"<p><strong>Aims: </strong>Human periodontal ligament stem cells (hPDLSCs) exhibit an enormous potential to regenerate periodontal tissue. However, their translatability to the clinical setting is constrained by technical difficulties in standardizing culture conditions. The aim was to assess complex culture conditions using a proteomic-based protocol to standardize multi-layer hPDLSC cultivation methodology.</p><p><strong>Materials and methods: </strong>hPDLSC-derived constructs were created with varying biological complexity. The simplest constructs were monolayer sheets of hPDLSCs cultured with fetal bovine serum (FBS) or Plasma Rich in Growth Factors supernatant (PRGFsn). The most complex constructs were triple-layered cell structures cultured with PRGFsn, with or without PRGF fibrin membrane (mPRGF). Ultrastructure and proteomic analyses were performed on these constructs.</p><p><strong>Results: </strong>PRGF supernatant improved protein expression related to extracellular matrix, adhesion, proliferation, and migration in hPDLSCs. PRGF fibrin scaffold upregulates proteins for cell activation, respiration, and electron transport. hPDLSCs on fibrin membrane show robust osteogenic potential through differential protein expression (ossification, tissue remodeling, morphogenesis, or cell migration) and overall homeostasis relative to less complex structures.</p><p><strong>Conclusion: </strong>Our data reveal the far-reaching potential of 3-dimensional constructs in combination with PRGF technology in periodontal regenerative applications.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"21-34"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in September 2024. 2024年9月来自干细胞研究和再生医学领域的行业更新。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-01-01 Epub Date: 2024-11-15 DOI: 10.1080/17460751.2024.2427501
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in September 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2024.2427501","DOIUrl":"10.1080/17460751.2024.2427501","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in September 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"20 1","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
iPSC stem cell banks: is it really necessary if we already have cord blood banks? iPSC干细胞库：如果我们已经有了脐带血库，真的有必要吗？
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1080/17460751.2025.2453332
David T Harris, Michael Badowski
{"title":"iPSC stem cell banks: is it really necessary if we already have cord blood banks?","authors":"David T Harris, Michael Badowski","doi":"10.1080/17460751.2025.2453332","DOIUrl":"10.1080/17460751.2025.2453332","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"17-20"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research advance of 3D printing for articular cartilage regeneration. 3D打印用于关节软骨再生的研究进展。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-01-01 Epub Date: 2025-02-17 DOI: 10.1080/17460751.2025.2466346
Haicheng Tao, Mingli Feng, Hui Feng, Hongchen Ren
{"title":"Research advance of 3D printing for articular cartilage regeneration.","authors":"Haicheng Tao, Mingli Feng, Hui Feng, Hongchen Ren","doi":"10.1080/17460751.2025.2466346","DOIUrl":"10.1080/17460751.2025.2466346","url":null,"abstract":"<p><p>Articular cartilage lesion frequently leads to dysfunction and the development of degenerative diseases, posing a significant public health challenge due to the limited self-healing capacity of cartilage tissue. Current surgical treatments, including marrow stimulation techniques and osteochondral autografts/allografts, have limited efficacy or have significant drawbacks, highlighting the urgent need for alternative strategies. Advances in 3D printing for cartilage regeneration have shown promising potential in creating cartilage-mimicking constructs, thereby opening new possibilities for cartilage repair. In this review, we summarize current surgical treatment methods and their limitations for addressing articular cartilage lesion, various 3D printing strategies and their features in cartilage tissue engineering, seed cells from different sources, and different types of biomaterials. We also explore the benefits, current challenges, and future research directions for 3D printing in the treatment of articular cartilage lesion within the field of cartilage tissue engineering.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"45-55"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BMSC-derived exosomes improve rheumatoid arthritis by regulating Th17 cell differentiation through targeting PRDM1. bmsc衍生外泌体通过靶向PRDM1调控Th17细胞分化改善类风湿关节炎。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-01-01 Epub Date: 2025-03-01 DOI: 10.1080/17460751.2025.2469426
Shaomin Chen, Xinxin Li, Yang Shen, Shichong Lin, Xiaolong Shui, Hua Zhu
{"title":"BMSC-derived exosomes improve rheumatoid arthritis by regulating Th17 cell differentiation through targeting PRDM1.","authors":"Shaomin Chen, Xinxin Li, Yang Shen, Shichong Lin, Xiaolong Shui, Hua Zhu","doi":"10.1080/17460751.2025.2469426","DOIUrl":"10.1080/17460751.2025.2469426","url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid arthritis (RA) is categorized as an autoimmune condition. Bone marrow-derived mesenchymal stromal cell (BMSC) derived exosome (BMSC-Exo) exert vital character in RA. We aimed to investigate the regulatory mechanism of BMSC-Exo in alleviating RA.</p><p><strong>Methods: </strong>BMSC was isolated from mouse bone marrow. Collagen-induced arthritis (CIA) was induced by injecting bovine type II collagen and complete Freund's adjuvant. Arthritis score, incidence, and withdrawal threshold were assessed. Hematoxylin-eosin staining was used to observe knee joint damage. CD4<sup>+</sup> T cells were isolated from the spleen, and T helper 17 (Th17) proportions were measured by flow cytometry. Caspase-1 activity was assessed.</p><p><strong>Results: </strong>BMSC-Exo injection reduced arthritis score and incidence of arthritis, and elevated the withdrawal threshold of CIA mice. BMSC-Exo also alleviated knee damage in CIA mice and reduced the Th17 proportion. BMSC-Exo down-regulated inflammatory cytokine levels, as well as caspase-1 activity. BMSC-Exo up-regulated PR Domain Zinc Finger Protein 1 (PRDM1) levels. PRDM1 knockdown in BMSC down-regulated PRDM1 expression in Exo but did not affect up-regulated PRDM1 expression in CD4<sup>+</sup> T cells. In vivo, BMSC-Exo affected RA pathology by acting on PRDM1.</p><p><strong>Conclusions: </strong>BMSC-Exo improved RA by promoting PRDM1 expression in CD4<sup>+</sup> T cells and inhibiting Th17 cell differentiation.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"35-44"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence powers regenerative medicine into predictive realm. 人工智能推动再生医学进入预测领域。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-12-01 Epub Date: 2024-12-11 DOI: 10.1080/17460751.2024.2437281
Armin Garmany, Andre Terzic
{"title":"Artificial intelligence powers regenerative medicine into predictive realm.","authors":"Armin Garmany, Andre Terzic","doi":"10.1080/17460751.2024.2437281","DOIUrl":"10.1080/17460751.2024.2437281","url":null,"abstract":"<p><p>The expanding regenerative medicine toolkit is reaching a record number of lives. There is a pressing need to enhance the precision, efficiency, and effectiveness of regenerative approaches and achieve reliable outcomes. While regenerative medicine has relied on an empiric paradigm, availability of big data along with advances in informatics and artificial intelligence offer the opportunity to inform the next generation of regenerative sciences along the discovery, translation, and application pathway. Artificial intelligence can streamline discovery and development of optimized biotherapeutics by aiding in the interpretation of readouts associated with optimal repair outcomes. In advanced biomanufacturing, artificial intelligence holds potential in ensuring quality control and assuring scalability through automated monitoring of process-critical variables mandatory for product consistency. In practice application, artificial intelligence can guide clinical trial design, patient selection, delivery strategies, and outcome assessment. As artificial intelligence transforms the regenerative horizon, caution is necessary to reduce bias, ensure generalizability, and mitigate ethical concerns with the goal of equitable access for patients and populations.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"611-616"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11703382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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