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Industry updates from the field of stem cell research and regenerative medicine in May 2025. 2025年5月来自干细胞研究和再生医学领域的行业更新。
IF 2.6 4区 医学
Regenerative medicine Pub Date : 2025-09-01 Epub Date: 2025-06-29 DOI: 10.1080/17460751.2025.2525719
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in May 2025.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2025.2525719","DOIUrl":"10.1080/17460751.2025.2525719","url":null,"abstract":"<p><p>Latest developments in the field of Advanced Therapy Medicinal Products and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in May 2025.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"20 9","pages":"353-363"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Building the framework for bioprinted human heart tissue: recent developments and future prospects. 构建生物打印人类心脏组织的框架：最近的发展和未来前景。
IF 2.6 4区 医学
Regenerative medicine Pub Date : 2025-09-01 Epub Date: 2025-09-11 DOI: 10.1080/17460751.2025.2558269
Victor A da Silva, Man Chi Leung, McGregor Clayton, Leya Oommen, Hannia Madrigal, Zachary Laksman, Bosco Yu, Stephanie M Willerth
{"title":"Building the framework for bioprinted human heart tissue: recent developments and future prospects.","authors":"Victor A da Silva, Man Chi Leung, McGregor Clayton, Leya Oommen, Hannia Madrigal, Zachary Laksman, Bosco Yu, Stephanie M Willerth","doi":"10.1080/17460751.2025.2558269","DOIUrl":"10.1080/17460751.2025.2558269","url":null,"abstract":"<p><p>Cardiac bioprinting holds great promise for creating patient-specific grafts and physiologically relevant drug-testing platforms, yet several critical challenges remain. This review identifies key barriers in current cardiac bioprinting approaches, including limitations in bioprinting precision, bioink development, vascularization, functional maturation, and scalable cell sourcing and processing. Recent advances, such as multimodal printing, hybrid bioinks, and perfusable constructs, are discussed with a focus on their application to drug discovery and graft fabrication. We emphasize that targeted maturation may suffice for drug screening, while graft applications demand greater complexity, scale, and immune compatibility. Addressing these challenges through integrated, multidisciplinary strategies will be essential to advance cardiac bioprinting toward clinical and preclinical impact.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"409-430"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LGBTQ+ persons, queer bioethics, and inclusivity in stem cell research and regenerative medicine. LGBTQ+人群，酷儿生物伦理，以及干细胞研究和再生医学的包容性。
IF 2.6 4区 医学
Regenerative medicine Pub Date : 2025-09-01 Epub Date: 2025-09-22 DOI: 10.1080/17460751.2025.2561461
Sydney E Prange, Leigh Turner
{"title":"LGBTQ+ persons, queer bioethics, and inclusivity in stem cell research and regenerative medicine.","authors":"Sydney E Prange, Leigh Turner","doi":"10.1080/17460751.2025.2561461","DOIUrl":"10.1080/17460751.2025.2561461","url":null,"abstract":"<p><p>Despite the increasing visibility of the LGBTQ+ (Lesbian, Gay, Bisexual, Transgender, Queer, and other expansive genders or sexual orientations) community, LGBTQ+ persons continue to face significant barriers, discrimination, and stigmatization in the health care space. The unique challenges faced by LGBTQ+ persons in healthcare led bioethicists to develop queer bioethics. This approach to ethical reflection suggests that we should develop understanding of biomedical and biological topics related to LGBTQ+ persons and that we should examine topics not traditionally associated with LGBTQ+ persons through a queer lens. Here, we argue that queer bioethics provides valuable new perspectives for improving stem cell science. We examine specific issues that should be examined using a queer bioethical framework for the benefit of all persons and the overall advancement of stem cell science. We specifically address strategies for stem cell donation recruitment, creation of more comprehensive stem cell models for precision medicine, and the promotion of more inclusive practices for LGBTQ+ persons in the stem cell science workforce. We contend that these important and timely topics provide suitable starting points for applying a queer bioethical perspective to stem cell research and regenerative medicine. Furthermore, we underscore the importance of addressing these topics in the current political climate.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"387-397"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stem cell-derived extracellular vesicles as a therapeutic for avascular necrosis: current status and future prospects. 干细胞来源的细胞外囊泡治疗缺血性坏死：现状和未来前景。
IF 2.6 4区 医学
Regenerative medicine Pub Date : 2025-09-01 Epub Date: 2025-09-23 DOI: 10.1080/17460751.2025.2561454
Vaijayanti Kale
{"title":"Stem cell-derived extracellular vesicles as a therapeutic for avascular necrosis: current status and future prospects.","authors":"Vaijayanti Kale","doi":"10.1080/17460751.2025.2561454","DOIUrl":"10.1080/17460751.2025.2561454","url":null,"abstract":"<p><p>Avascular necrosis (AVN), also referred to as osteonecrosis (ON), is a major clinical challenge in orthopedic practice. Current treatment strategies include surgical options such as core decompression, as well as non-surgical approaches including statin therapy, weight reduction, and physiotherapy. Regenerative therapies - such as platelet-rich plasma injections, autologous bone marrow cell concentrates, and mesenchymal stem/stromal cells (MSCs), among others have shown some success. Although induced pluripotent stem cells (iPSCs) represent a promising source for cell therapy, their clinical application is restricted due to the risk of teratoma formation. In this context, the therapeutic potential of extracellular vesicles (EVs) secreted by stem cells has emerged as a relatively new area of investigation. This review summarizes findings from preclinical studies in animal models that have explored the use of MSC- and iPSC-derived EVs in the regenerative treatment of AVN/ON. Compared with MSC-EVs, the therapeutic use of iPSC-EVs has progressed more slowly, partly due to the high cost of expanding iPSCs to obtain a sufficient quantity of their EVs. Therefore, instead of using iPSC-derived EVs, the use of a cocktail of EVs secreted by iPSC-derived cellular derivatives may represent a safer, more cost-effective, and potentially more efficacious strategy for treating AVN.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"399-408"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in July 2025. 2025年7月来自干细胞研究和再生医学领域的行业更新。
IF 2.6 4区 医学
Regenerative medicine Pub Date : 2025-08-30 DOI: 10.1080/17460751.2025.2551422
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in July 2025.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2025.2551422","DOIUrl":"https://doi.org/10.1080/17460751.2025.2551422","url":null,"abstract":"<p><p>Latest developments in the field of Advanced Therapy Medicinal Products and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in July 2025.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in April 2025. 2025年4月来自干细胞研究和再生医学领域的行业更新。
IF 2.6 4区 医学
Regenerative medicine Pub Date : 2025-08-01 Epub Date: 2025-06-06 DOI: 10.1080/17460751.2025.2514908
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in April 2025.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2025.2514908","DOIUrl":"https://doi.org/10.1080/17460751.2025.2514908","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in April 2025.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"20 8","pages":"317-324"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustained long-term benefits of autologous subconjunctival platelet-rich plasma injections for severe dry eye disease. 自体结膜下富血小板血浆注射治疗严重干眼病的持续长期疗效
IF 2.6 4区 医学
Regenerative medicine Pub Date : 2025-08-01 Epub Date: 2025-08-07 DOI: 10.1080/17460751.2025.2544486
Amparo M Mora, Carlos M Córdoba, Mario A Jimenez-Mora, Fabio Daniel Padilla-Pantoja
{"title":"Sustained long-term benefits of autologous subconjunctival platelet-rich plasma injections for severe dry eye disease.","authors":"Amparo M Mora, Carlos M Córdoba, Mario A Jimenez-Mora, Fabio Daniel Padilla-Pantoja","doi":"10.1080/17460751.2025.2544486","DOIUrl":"10.1080/17460751.2025.2544486","url":null,"abstract":"<p><p>Dry eye disease (DED) is a multifactorial condition that significantly impairs patients' quality of life, particularly in its severe forms, which are often unresponsive to conventional therapies. In this retrospective study, we evaluated the long-term efficacy and safety of subconjunctival platelet-rich plasma (PRP) injections in six Hispanic women with refractory DED. A total of eleven eyes were treated with a standardized protocol consisting of five PRP injections - three administered monthly, followed by two spaced two months apart - and followed for a period of 12 months. Clinical assessments included both subjective and objective measures, such as the Ocular Surface Disease Index (OSDI), Schirmer test, tear breakup time (BUT), and ocular surface staining with fluorescein and lissamine green. Significant and sustained improvements were observed across all parameters throughout the follow-up period, and no serious adverse events were reported. Notably, this is the first study to demonstrate that subconjunctival PRP injections may provide long-term symptomatic relief in patients with refractory DED. These findings suggest that this novel, well-tolerated, and accessible therapeutic approach may represent a promising alternative for individuals who do not respond to conventional treatments and warrant further investigation in larger populations.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"331-338"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12407845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing methods for regenerative endodontics. 再生牙髓学的优化方法。
IF 2.6 4区 医学
Regenerative medicine Pub Date : 2025-08-01 Epub Date: 2025-09-01 DOI: 10.1080/17460751.2025.2546759
Alexandre Henrique Dos Reis-Prado, Francine Benetti, Marco C Bottino, Renan Dal-Fabbro
{"title":"Optimizing methods for regenerative endodontics.","authors":"Alexandre Henrique Dos Reis-Prado, Francine Benetti, Marco C Bottino, Renan Dal-Fabbro","doi":"10.1080/17460751.2025.2546759","DOIUrl":"10.1080/17460751.2025.2546759","url":null,"abstract":"<p><p>Regenerative endodontics has emerged as a promising and recognized approach for treating necrotic young permanent teeth. Based on advanced tissue engineering strategies, regenerative therapies, such as cell homing and cell-based transplantation, have been extensively investigated to achieve functional regeneration of the injured pulp-dentin complex. Injectable, thermo-responsive, and tailor-made 3D-printed scaffolds that carry antimicrobial, anti-inflammatory, and other signaling cues provide a powerful means of delivering drugs precisely within the narrow, branching anatomy of the root canal. By enhancing antimicrobial decontamination, an essential step in the regenerative process, these biomaterials establish a permissive microenvironment that promotes cellular migration, adhesion, and subsequent differentiation. Therefore, the current narrative review emphasizes emerging strategies and their optimization to enhance regenerative outcomes in immature teeth affected by pulp necrosis and apical periodontitis.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"20 8","pages":"339-351"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological tendon regeneration, are we almost there or is it still a stretch? 生物肌腱再生，我们快实现了吗，还是还有很长的路要走？
IF 2.6 4区 医学
Regenerative medicine Pub Date : 2025-08-01 Epub Date: 2025-08-13 DOI: 10.1080/17460751.2025.2546758
Ahmet Engin Pazarceviren, Minoo Bastani, Dmitriy Sheyn
{"title":"Biological tendon regeneration, are we almost there or is it still a stretch?","authors":"Ahmet Engin Pazarceviren, Minoo Bastani, Dmitriy Sheyn","doi":"10.1080/17460751.2025.2546758","DOIUrl":"10.1080/17460751.2025.2546758","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"325-329"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward improved AAV gene therapies for retinal disorders: challenges and advances. 改进AAV基因治疗视网膜疾病：挑战和进展。
IF 2.6 4区 医学
Regenerative medicine Pub Date : 2025-07-01 Epub Date: 2025-08-07 DOI: 10.1080/17460751.2025.2544497
Oliver Siontas, Mika Brown, Seungkuk Ahn
{"title":"Toward improved AAV gene therapies for retinal disorders: challenges and advances.","authors":"Oliver Siontas, Mika Brown, Seungkuk Ahn","doi":"10.1080/17460751.2025.2544497","DOIUrl":"10.1080/17460751.2025.2544497","url":null,"abstract":"<p><p>Adeno-associated virus (AAV) vectors have transformed the landscape of in vivo gene therapy, with retinal diseases emerging as a major area of progress. The eye offers unique advantages as a therapeutic target: it is accessible, compartmentalized, and relatively immune-privileged, allowing localized delivery with reduced systemic effects. The landmark 2017 approval of the first AAV-based gene therapy for an inherited retinal disorder sparked a surge of clinical trials using AAV vectors - underscoring their potential for treating genetic eye diseases. However, challenges remain, including AAV's limited capacity for large genes, suboptimal precision in cell-type-specific targeting, and inefficient transduction of certain retinal cells via minimally invasive routes. In response, researchers are engineering next-generation AAV capsids, optimizing gene expression cassettes, developing novel delivery strategies, and advancing tissue and organoid-based screening platforms. This article highlights these efforts as essential to overcoming current barriers in retinal AAV gene therapy.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"299-303"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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