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Beyond transplants: current and future therapeutic potential of amniotic membrane extract (AME) in ophthalmology. 超越移植：羊膜提取物（AME）在眼科中的当前和未来治疗潜力。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-02-01 Epub Date: 2025-03-03 DOI: 10.1080/17460751.2025.2472578
Ilayda Korkmaz, Mehmet Gurdal, Mesut Arici, Ozlem Barut Selver
{"title":"Beyond transplants: current and future therapeutic potential of amniotic membrane extract (AME) in ophthalmology.","authors":"Ilayda Korkmaz, Mehmet Gurdal, Mesut Arici, Ozlem Barut Selver","doi":"10.1080/17460751.2025.2472578","DOIUrl":"10.1080/17460751.2025.2472578","url":null,"abstract":"<p><p>There is no established consensus or standardized method for the preparation of amniotic membrane extract (AME). Consequently, various preparation, preservation, and sterilization techniques have been employed. To obtain AME rich in bioactive components with high therapeutic efficacy, each step of the preparation process is of critical importance. The appropriate procurement of the amniotic membrane minimizes the risk of infection transmission and reduces inter- and intra-donor variability. For the subsequent extraction process, different approaches are utilized due to factors such as laboratory infrastructure variability and the lack of a standardized method. Although lyophilization has recently emerged as a prominent method for the long-term preservation of AME, further investigation is required to assess its impact on the biochemical composition and clinical efficacy of the membrane. In ophthalmology, <i>in vitro</i>, <i>in vivo</i>, and clinical studies indicate that AME supports corneal epithelial regeneration, suppresses inflammation, and is a well-tolerated therapeutic agent. Consequently, further studies are still needed to enhance the effective release of therapeutic components from the amniotic membrane, improve the quality and consistency of AME, and preserve its content over an extended period. Thus, the clinical application of AME-derived products in the form of eye drops will become more widespread in the future.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"97-109"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction. 更正。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-02-01 Epub Date: 2024-11-12 DOI: 10.1080/17460751.2024.2427474
{"title":"Correction.","authors":"","doi":"10.1080/17460751.2024.2427474","DOIUrl":"10.1080/17460751.2024.2427474","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"111"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in October 2024. 2024年10月来自干细胞研究和再生医学领域的行业更新。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-02-01 Epub Date: 2024-12-27 DOI: 10.1080/17460751.2024.2445466
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in October 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2024.2445466","DOIUrl":"10.1080/17460751.2024.2445466","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in October 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"57-63"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Open-source software to calculate the static sciatic index automatically. 开源软件自动计算静态坐骨指数。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-02-01 Epub Date: 2025-03-18 DOI: 10.1080/17460751.2025.2476390
Simão Laranjeira, Owein Guillemot-Legris, Gedion Girmahun, James B Phillips, Rebecca J Shipley
{"title":"Open-source software to calculate the static sciatic index automatically.","authors":"Simão Laranjeira, Owein Guillemot-Legris, Gedion Girmahun, James B Phillips, Rebecca J Shipley","doi":"10.1080/17460751.2025.2476390","DOIUrl":"10.1080/17460751.2025.2476390","url":null,"abstract":"<p><strong>Background: </strong>The static sciatic index is commonly used in rat models of nerve crush injury to quantify functional recovery from new therapies under evaluation. However, it is challenging to standardize these measurements across different investigations, and the process is labor intensive.</p><p><strong>Material/methods: </strong>A new machine learning method was previously developed that performs these measurements automatically and consistently. Here, the approach is tested using two data sets that use different experimental setups, and end-user requirements are evaluated.</p><p><strong>Results: </strong>The model's outputs presented a nerve regeneration profile comparable to the manual measurements and outperformed the latter by having a much tighter standard deviation (± 5- ± 10 compared to ± 10 - ± 50).</p><p><strong>Conclusion: </strong>An inexpensive automatic tool that can perform functional analysis for nerve repair research was developed and tested. The software is available open source to facilitate its dissemination and use in quantifying recovery from peripheral nerve crush injury.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"77-85"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The future of ex vivo hematopoietic stem cell gene editing: what's next. 体外造血干细胞基因编辑的未来：下一步是什么？
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-02-01 Epub Date: 2025-03-26 DOI: 10.1080/17460751.2025.2480003
Alessia Cavazza, Giorgia Santilli
{"title":"The future of ex vivo hematopoietic stem cell gene editing: what's next.","authors":"Alessia Cavazza, Giorgia Santilli","doi":"10.1080/17460751.2025.2480003","DOIUrl":"10.1080/17460751.2025.2480003","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"73-76"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in November 2024. 2024年11月来自干细胞研究和再生医学领域的行业更新。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-01-19 DOI: 10.1080/17460751.2025.2453325
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in November 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2025.2453325","DOIUrl":"https://doi.org/10.1080/17460751.2025.2453325","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in November 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-8"},"PeriodicalIF":2.4,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in December 2024. 2024年12月来自干细胞研究和再生医学领域的行业更新。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-01-18 DOI: 10.1080/17460751.2025.2453324
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in December 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2025.2453324","DOIUrl":"https://doi.org/10.1080/17460751.2025.2453324","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in December 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-9"},"PeriodicalIF":2.4,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generating functional cardiac tissue for regenerative medicine applications: a 3D bioprinting approach. 为再生医学应用生成功能性心脏组织：3D生物打印方法。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-01-01 Epub Date: 2025-02-21 DOI: 10.1080/17460751.2025.2469433
Boeun Hwang, Holly Bauser-Heaton, Vahid Serpooshan
{"title":"Generating functional cardiac tissue for regenerative medicine applications: a 3D bioprinting approach.","authors":"Boeun Hwang, Holly Bauser-Heaton, Vahid Serpooshan","doi":"10.1080/17460751.2025.2469433","DOIUrl":"10.1080/17460751.2025.2469433","url":null,"abstract":"","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"11-15"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of increasingly complex cell culture conditions on the proteome of human periodontal ligament stem cells. 日益复杂的细胞培养条件对人牙周韧带干细胞蛋白质组的影响。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-01-01 Epub Date: 2025-01-04 DOI: 10.1080/17460751.2024.2445931
Asier Fullaondo, Mar Zalduendo, Nerea Osinalde, Mohammad H Alkhraisat, Eduardo Anitua, Ana M Zubiaga
{"title":"Impact of increasingly complex cell culture conditions on the proteome of human periodontal ligament stem cells.","authors":"Asier Fullaondo, Mar Zalduendo, Nerea Osinalde, Mohammad H Alkhraisat, Eduardo Anitua, Ana M Zubiaga","doi":"10.1080/17460751.2024.2445931","DOIUrl":"10.1080/17460751.2024.2445931","url":null,"abstract":"<p><strong>Aims: </strong>Human periodontal ligament stem cells (hPDLSCs) exhibit an enormous potential to regenerate periodontal tissue. However, their translatability to the clinical setting is constrained by technical difficulties in standardizing culture conditions. The aim was to assess complex culture conditions using a proteomic-based protocol to standardize multi-layer hPDLSC cultivation methodology.</p><p><strong>Materials and methods: </strong>hPDLSC-derived constructs were created with varying biological complexity. The simplest constructs were monolayer sheets of hPDLSCs cultured with fetal bovine serum (FBS) or Plasma Rich in Growth Factors supernatant (PRGFsn). The most complex constructs were triple-layered cell structures cultured with PRGFsn, with or without PRGF fibrin membrane (mPRGF). Ultrastructure and proteomic analyses were performed on these constructs.</p><p><strong>Results: </strong>PRGF supernatant improved protein expression related to extracellular matrix, adhesion, proliferation, and migration in hPDLSCs. PRGF fibrin scaffold upregulates proteins for cell activation, respiration, and electron transport. hPDLSCs on fibrin membrane show robust osteogenic potential through differential protein expression (ossification, tissue remodeling, morphogenesis, or cell migration) and overall homeostasis relative to less complex structures.</p><p><strong>Conclusion: </strong>Our data reveal the far-reaching potential of 3-dimensional constructs in combination with PRGF technology in periodontal regenerative applications.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"21-34"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in September 2024. 2024年9月来自干细胞研究和再生医学领域的行业更新。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2025-01-01 Epub Date: 2024-11-15 DOI: 10.1080/17460751.2024.2427501
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in September 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2024.2427501","DOIUrl":"10.1080/17460751.2024.2427501","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in September 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"20 1","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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